Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acs.macromol.5c00257

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Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acs.macromol.4c02480

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Publishing type：Research paper (scientific journal)  

DOI： 10.1021/prechem.4c00066

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Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acs.macromol.4c00924

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Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acs.macromol.3c01672

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.tet.2021.132225

Web of Science

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Language：English   Publishing type：Research paper (scientific journal)  

A bifunctional amino sulfonamide-catalyzed asymmetric conjugate addition of aldehydes to alkenyl alkynyl ketimines as reactive surrogates for enones has been developed. Use of a phenylcyclopropane-based amino sulfonamide catalyst, which can activate and orient the ketimines through hydrogen bonding, affords the desired conjugate adducts with high chemo-, diastereo- and enantioselectivity.

DOI： 10.1039/d0cc07842e

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

Stereoselective Mannich reactions of aldehydes with ketimines provide chiral β-amino aldehydes that bear an α-tert-amine moiety. However, the structural variation of the ketimines is limited due to the formation of inseparable E/Z isomers, low reactivity, and other synthetic difficulties. In this study, a highly diastereodivergent synthesis of hitherto difficult-to-access β-amino aldehydes that bear a chiral α-tert-amine moiety was achieved using the amine-catalyzed Mannich reactions of aldehydes with less-activated Z-ketimines that bear both alkyl and alkynyl groups.

DOI： 10.1039/d0sc05269h

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

An enantioselective synthesis of cis-dihydropyrans as the formal HDA reaction products was achieved through the catalyst-controlled anti-selective conjugate addition of aldehydes to β,γ-unsaturated α-keto esters. The observed unusual cis-selectivity could be attributed to the stabilization of the less favorable transition state for anti-conjugate adducts by the hydrogen bonding between the hydroxy group of the amino diol catalyst and β,γ-unsaturated α-keto esters.

DOI： 10.1039/C8CC01443D

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

α-Selenoenones could be employed as Z-allyl precursors in the chiral amine-catalyzed asymmetric conjugate addition of aldehydes. The obtained formal allylation product, a Z-olefin having a sulfonate leaving group, was employed as a synthetically useful chiral alkylating agent.

DOI： 10.1039/c7cc08691a

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

An efficient synthesis of novel chiral tritylpyrrolidine derivatives has been developed. Single stereoisomers of various tritylpyrrolidine derivatives can be readily obtained through diastereomer separation by simple silica gel column chromatography. Representative compounds of this class have been shown to be efficient amine organocatalysts for asymmetric benzoyloxylation.

DOI： 10.1021/acs.joc.7b02562

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

In situ generation of less accessible N-Boc-protected imines from aldehydes and their application to the direct three-component Mannich reaction with β-dicarbonyls were realized. The catalyst-free aldol reaction of ynals with β-dicarbonyls was also developed.

DOI： 10.1039/c7ob01126a

PubMed

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