Organization
School of Science Assistant Professor
Title
Assistant Professor
External link
yamashina masahiro
News & Topics
-
Developing Self-Complementary Macrocycles with Ingenious Molecules
2022/10/17
Languages： English
Virus capsids can be formed through the self-complementary assembly of a single class of protein molecules. However, mimicking nature by making higher-ordered structures from artificial molecules has
-
レアメタル不要の巨大人工分子の開発に成功 ウイルスを模倣した自己精密集積化を実現
2022/10/14
Languages： Japanese
要点 ウイルス構造を模倣し、独自のピンセット分子から蛍光性環状6量体を構築 酸性条件では環状6量体がさらに集まり、空洞をもつ巨大球状集合体を形成 レアメタル不要の分子構築によって持続可能社会の実現に貢献 概要東京工業大学 理学院 化学系の山科雅裕助教と豊田真司教授、澤中祐太大学院生（当時）、大津博義助教（当時）の研究グループは、ウイルスの構築原理を利用し、ピンセット状の形状を持つ有機分子
-
『混ぜるだけ』で作れる両親媒性分子 多様な機能性分子の創出に向けた新手段としても期待
2021/07/06
Languages： Japanese
要点-安価な原料を混ぜるだけで作れる、両親媒性分子の新規合成法を開発-一般的な両親媒性分子より高い性能を示し、様々な誘導体の作り分けも可能-水中で球状のミセルを形成し、疎水性の色素分子の取り込みにも成功概要東京工業大学理学院化学系の山科雅裕助教と鈴木颯大学院生、豊田真司教授らの研究グループは、独自に
-
Just Mix It Up: New Synthetic Method for Making Amphiphilic Molecules without Additives
2021/07/05
Languages： English
Amphiphilic molecules, which aggregate and encapsulate molecules in water, find use in several fields of chemistry. The simple, additive-free connect
-
ナノサイズの「異空間」をもつ新物質 反芳香族分子で構築された新しい分子ケージの開発に成功
2019/10/28
Languages： Japanese
要点-反芳香族分子を基盤にした分子ナノケージの構築に成功-反芳香族分子に囲まれた内部空間の性質を理論的に解明-取り込ませた分子と反芳香族分子間の反遮蔽効果を実験的に証明概要東京工業大学理学院化学系の山科雅裕助教（当時・JSPS海外特別研究員
-
Creating a nanospace like no other Scientists build a nanocage with antiaromatic walls
2019/10/28
Languages： English
Researchers at Tokyo Institute of Technology, the University of Cambridge, and the University of Copenhagen have built a self-assembled nanocage with a very unusual nanospace: Its walls are made o
-
性ホルモンの男女を見分ける分子カプセル 男性ステロイドホルモンの超高感度センシング法を開発
2019/04/22
Languages： Japanese
水中で分子カプセルが種々のステロイド性ホルモンを強く捕捉 男性と女性ホルモンの混合物から男性ホルモンを選択的に捕捉 数ナノグラム量の男性ホルモンの高感度蛍光センシングに成功
-
2019/04/22
Languages： English
Researchers at Tokyo Tech have revealed that an artificial receptor preferentially binds male steroid hormones from a mixture of male and female hormones in water. Based on their findings, they succeeded in the preparation of a prototype detection system for male hormones at the nanogram level. This achievement could lead to the development of ultrasensitive analytical devices for medical diagnostics and anti-doping testing in sports.
-
2014/08/22
Languages： Japanese
Papers
-
Macrocycles composed of biphenylene and butadiyne units with antiaromatic character
Shoko Nagayama, Hiroki Kawakatsu, Daisuke Asai, Takumi Yokoyama, Masahiro Yamashina, Shinji Toyota, Kazukuni Tahara
CHEMICAL SCIENCE 16 ( 37 ) 17287 - 17297 2025.9
-
Solid-State Self-Assembly: Exclusive Formation and Dynamic Interconversion of Discrete Cyclic Assemblies Based on Molecular Tweezers. International journal
Koki Okabe, Masahiro Yamashina, Eiji Tsurumaki, Hidehiro Uekusa, Shinji Toyota
The Journal of organic chemistry 89 ( 13 ) 9488 - 9495 2024.7
-
Azaylide-based gemini amphiphiles displaying unique self-assembling behavior via an even–odd effect of alkyl linker chain length
Yoshimori Akiyama, Masahiro Yamashina, Shinji Toyota
Soft Matter 2024
-
Transformation of Highly Hydrophobic Triarylphosphines into Amphiphiles via Staudinger Reaction with Hydrophilic Trichlorophenyl Azide. International journal
Hayate Suzuki, Yoshimori Akiyama, Masahiro Yamashina, Yuya Tanaka, Shinji Toyota
Chemistry (Weinheim an der Bergstrasse, Germany) 29 ( 72 ) e202303017 2023.12
-
Controlling the Assembly of PdII/Bianthryl‐Based Monomeric and Dimeric Interlocked Cages by Steric Effects
Sota Watanabe, Masahiro Yamashina, Eiji Tsurumaki, Shinji Toyota
ChemistryEurope 2023.11
-
A self-complementary macrocycle by a dual interaction system. International journal
Yuta Sawanaka, Masahiro Yamashina, Hiroyoshi Ohtsu, Shinji Toyota
Nature communications 13 ( 1 ) 5648 - 5648 2022.9
-
Synthesis of Azaylide‐Based Amphiphiles by the Staudinger Reaction
Masahiro Yamashina, Hayate Suzuki, Natsuki Kishida, Michito Yoshizawa, Shinji Toyota
Angewandte Chemie 133 ( 33 ) 18059 - 18063 2021.8
-
Synthesis of Azaylide-Based Amphiphiles by the Staudinger Reaction
Masahiro Yamashina, Hayate Suzuki, Natsuki Kishida, Michito Yoshizawa, Shinji Toyota
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 ( 33 ) 17915 - 17919 2021.8
-
Recognition and Stabilization of Unsaturated Fatty Acids by a Polyaromatic Receptor
Keita Niki, Takahiro Tsutsui, Masahiro Yamashina, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 ( 26 ) 10489 - 10492 2020.6
-
Recognition and Stabilization of Unsaturated Fatty Acids by a Polyaromatic Receptor Reviewed
Keita Niki, Takahiro Tsutsui, Masahiro Yamashina, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 ( 26 ) 10489 - 10492 2020.6
-
An antiaromatic-walled nanospace
Masahiro Yamashina, Yuya Tanaka, Roy Lavendomme, Tanya K. Ronson, Michael Pittelkow, Jonathan R. Nitschke
NATURE 574 ( 7779 ) 511 - + 2019.10
-
A polyaromatic receptor with high androgen affinity
Masahiro Yamashina, Takahiro Tsutsui, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
SCIENCE ADVANCES 5 ( 4 ) 2019.4
-
Open versus Closed Polyaromatic Nanocavity: Enhanced Host Abilities toward Large Dyes and Pigments
Takahiro Tsutsui, Shunsuke Kusaba, Masahiro Yamashina, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 25 ( 17 ) 4320 - 4324 2019.3
-
Cramming versus threading of long amphiphilic oligomers into a polyaromatic capsule
Masahiro Yamashina, Shunsuke Kusaba, Munetaka Akita, Takashi Kikuchi, Michito Yoshizawa
NATURE COMMUNICATIONS 9 2018.10
-
Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water
Shunsuke Kusaba, Masahiro Yamashina, Munetaka Akita, Takashi Kikuchi, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 ( 14 ) 3706 - 3710 2018.3
-
Self-Assembly Process of a Pd2L4 Capsule: Steric Interactions between Neighboring Components Favor the Formation of Large Intermediates
Shumpei Kai, Masanori Nakagawa, Tatsuo Kojima, Xin Li, Masahiro Yamashina, Michito Yoshizawa, Shuichi Hiraoka
CHEMISTRY-A EUROPEAN JOURNAL 24 ( 16 ) 3965 - 3969 2018.3
-
Exact mass analysis of sulfur clusters upon encapsulation by a polyaromatic capsular matrix
Sho Matsuno, Masahiro Yamashina, Yoshihisa Sei, Munetaka Akita, Akiyoshi Kuzume, Kimihisa Yamamoto, Michito Yoshizawa
NATURE COMMUNICATIONS 8 2017.9
-
A polyaromatic nanocapsule as a sucrose receptor in water
Masahiro Yamashina, Munetaka Akita, Taisuke Hasegawa, Shigehiko Hayashi, Michito Yoshizawa
SCIENCE ADVANCES 3 ( 8 ) 2017.8
-
Coordination-driven Nanostructures with Polyaromatic Shells
Michito Yoshizawa, Masahiro Yamashina
CHEMISTRY LETTERS 46 ( 2 ) 163 - 171 2017.2
-
Recognition of Multiple Methyl Groups on Aromatic Rings by a Polyaromatic Cavity
Masahiro Yamashina, Sho Matsuno, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 40 ) 14147 - 14150 2016.9
-
M2L4 coordination capsules with tunable anticancer activity upon guest encapsulation
Anife Ahmedova, Rositsa Mihaylova, Denitsa Momekova, Pavletta Shestakova, Silviya Stoykova, Joana Zaharieva, Masahiro Yamashina, Georgi Momekov, Munetaka Akita, Michito Yoshizawa
DALTON TRANSACTIONS 45 ( 33 ) 13214 - 13221 2016.9
-
Anticancer Potencies of Pt-II- and Pd-II-linked M2L4 Coordination Capsules with Improved Selectivity
Anife Ahmedova, Denitsa Momekova, Masahiro Yamashina, Pavletta Shestakova, Georgi Momekov, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 11 ( 4 ) 474 - 477 2016.2
-
Preparation of Highly Fluorescent Host-Guest Complexes with Tunable Color upon Encapsulation
Masahiro Yamashina, Matthew M. Sartin, Yoshihisa Sei, Munetaka Akita, Satoshi Takeuchi, Tahei Tahara, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137 ( 29 ) 9266 - 9269 2015.7
-
Anisotropic Expansion of an M2L4 Coordination Capsule: Host Capability and Frame Rearrangement
Masahiro Yamashina, Tsubasa Yuki, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 21 ( 11 ) 4200 - 4204 2015.3
-
Safe storage of radical initiators within a polyaromatic nanocapsule
Masahiro Yamashina, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
NATURE COMMUNICATIONS 5 2014.8
MISC
-
Synthesis of Azaylide-based Amphiphile with a Phosphine Coordination Site and Evaluation of its Assembling Behavior
内藤翔, 秋山善守, 山科雅裕, 豊田真司, 井手智仁
日本化学会春季年会講演予稿集(Web) 104th 2024
Research Projects
-
アザイリド形成に基づく新奇モノメリック型/ジェミニ型両親媒性分子の創製
Grant number：22K14662 2022.4 - 2024.3
日本学術振興会 科学研究費助成事業 若手研究
山科 雅裕
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
-
Development of fluorescent supramolecular materials based on the fluorescent double-tweezer-shaped molecules
Grant number：20K15255 2020.4 - 2022.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Yamashina Masahiro
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Amphiphilic molecules that can self-aggregate and encapsulate guest molecules in water have attracted attention in various fields. Herein, we report the development of new amphiphiles through the Staudinger reaction. Simple mixing of chlorinated aryl azide with a hydrophilic moiety and various triarylphosphines (PAr3) gave rise to azaylide-based amphiphiles NPAr3, rapidly and quantitatively. The obtained NPAr3 formed ca. 2 nm-sized spherical aggregates (NPAr3)n in water. The hydrolysis of NPAr3 was significantly suppressed as compared with those of non-chlorinated amphiphiles. Computational studies revealed that the stability is mainly governed by the decrease in LUMO around the phosphorus atom owing to the o-substituted halogen groups. Furthermore, hydrophobic dyes such as Nile red and BODIPY were encapsulated by the spherical aggregates (NPAr3)n in water.
-
Construction of novel fluorescent materials based on the self-assembly of curved pi-conjugated surfaces
Grant number：19K23623 2019.8 - 2021.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up
Yamashina Masahiro
Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）
In this study, we could demonstrate the construction of an antiaromatic-walled nanospace within a self-assembled cage composed of four metal ions with six identical antiaromatic walls. Although norcorrole has flat structure, each norcorrole wall displays a 165.4°bend inwards. Calculations indicate that the magnetic effects of the antiaromatic moieties surrounding this nanospace reinforce each other. This prediction is confirmed by 1H nuclear magnetic resonance (NMR) signals of bound guest molecules, which are observed at chemical shift values of up to 24 parts per million (ppm), owing to the combined antiaromatic deshielding effect of the surrounding rings.