The Japanese Biochemical Society

Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells Reviewed

Fumimasa Kubo, Donna Maretta Ariestanti, Souta Oki, Taku Fukuzawa, Ryotaro Demizu, Tomoya Sato, Rahmaningsih Mara Sabirin, Shigehisa Hirose, Nobuhiro Nakamura

Respiratory Research   20 ( 1 )   2019.12

Ubiquitin System Invited Reviewed

Nobuhiro Nakamura

International Journal of Molecular Sciences   19 ( 4 )   1080 - 1080   2018.4

Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear Reviewed

Hiroko Matsumoto, Shoko Fujiwara, Hisako Miyagi, Nobuhiro Nakamura, Yasuhiro Shiga, Toshihiro Ohta, Mikio Tsuzuki

MARINE BIOTECHNOLOGY   19 ( 5 )   430 - 440   2017.10

Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression. Reviewed

Miyagi, Hisako, Nag, Kakon, Sultana, Naznin, Munakata, Keijiro, Hirose, Shigehisa, Nakamura, Nobuhiro

Gene   577 ( 2 )   265 - 274   2016

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase. Reviewed

Harada, Kumi, Kato, Masako, Nakamura, Nobuhiro

International journal of molecular sciences   17 ( 11 )   2016

Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation Reviewed

Ariestanti, Donna Maretta, Ando, Hikaru, Hirose, Shigehisa, Nakamura, Nobuhiro

Journal of Biological Chemistry   290 ( 17 )   11032 - 11040   2015

Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole Reviewed

Nag, Kakon, Sultana, Naznin, Kato, Akira, Dranik, Anna, Nakamura, Nobuhiro, Kutsuzawa, Koichi, Hirose, Shigehisa, Akaike, Toshihiro

General and Comparative Endocrinology   212   156 - 162   2015

Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6 Reviewed

Nakamura, Nobuhiro, Harada, Kumi, Kato, Masako, Hirose, Shigehisa

Experimental Cell Research   328 ( 1 )   207 - 216   2014

Close association of carbonic anhydrase (CA2a and CA15a), Na+/H+ exchanger (Nhe3b), and ammonia transporter Rhcg1 in zebrafish ionocytes responsible for Na+ uptake Reviewed

Ito, Yusuke, Kobayashi, Sayako, Nakamura, Nobuhiro, Miyagi, Hisako, Esaki, Masahiro, Hoshijima, Kazuyuki, Hirose, Shigehisa

Frontiers in Physiology   4   2013

Identification and properties of a novel variant of NBC4 (Na+/HCO3- co-transporter 4) that is predominantly expressed in the choroid plexus Reviewed

Fukuda, Hidekazu, Hirata, Taku, Nakamura, Nobuhiro, Kato, Akira, Kawahara, Katsumasa, Wakabayashi, Shigeo, Chang, Min-Hwang, Romero, Michael F., Hirose, Shigehisa

Biochemical Journal   450   179 - 187   2013

Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D Reviewed

Fukuzawa, Taku, Ishida, Junji, Kato, Akira, Ichinose, Taro, Ariestanti, Donna Maretta, Takahashi, Tomoya, Ito, Kunitoshi, Abe, Jumpei, Suzuki, Tomohiro, Wakana, Shigeharu, Fukamizu, Akiyoshi, Nakamura, Nobuhiro, Hirose, Shigehisa

Plos One   8 ( 7 )   2013

MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation Reviewed

Zhao, Boqiang, Ito, Kunitoshi, Iyengar, Prasanna Vasudevan, Hirose, Shigehisa, Nakamura, Nobuhiro

Histochemistry and Cell Biology   139 ( 3 )   447 - 460   2013

Ubiquitination regulates the morphogenesis and function of sperm organelles. Reviewed

Nakamura, Nobuhiro

Cells   2 ( 4 )   732 - 50   2013

Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids Reviewed

Yogo, Keiichiro, Tojima, Hidehiro, Ohno, Jun-ya, Ogawa, Takuya, Nakamura, Nobuhiro, Hirose, Shigehisa, Takeya, Tatsuo, Kohsaka, Tetsuya

Histochemistry and Cell Biology   137 ( 1 )   53 - 65   2012

MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors Reviewed

Han, Sang-oh, Xiao, Kunhong, Kim, Jihee, Wu, Jiao-Hui, Wisler, James W., Nakamura, Nobuhiro, Freedman, Neil J., Shenoy, Sudha K.

Journal of Cell Biology   199 ( 5 )   817 - 830   2012

Membrane-associated RING-CH 10 (MARCH10 Protein) Is a Microtubule-associated E3 Ubiquitin Ligase of the Spermatid Flagella Reviewed

Iyengar, Prasanna Vasudevan, Hirota, Tsuyoshi, Hirose, Shigehisa, Nakamura, Nobuhiro

Journal of Biological Chemistry   286 ( 45 )   39082 - 39090   2011

The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function. Reviewed

Nakamura, Nobuhiro

Membranes   1 ( 4 )   354 - 393   2011

Rhesus Glycoprotein P2 (Rhp2) Is a Novel Member of the Rh Family of Ammonia Transporters Highly Expressed in Shark Kidney Reviewed

Nakada, Tsutomu, Westhoff, Connie M., Yamaguchi, Yoko, Hyodo, Susumu, Li, Xiaojin, Muro, Takayuki, Kato, Akira, Nakamura, Nobuhiro, Hirose, Shigehisa

Journal of Biological Chemistry   285 ( 4 )   2653 - 2664   2010

Identification of zebrafish Fxyd11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis Reviewed

Saito, Kaori, Nakamura, Nobuhiro, Ito, Yusuke, Hoshijima, Kazuyuki, Esaki, Masahiro, Zhao, Boqiang, Hirose, Shigehisa

Frontiers in Physiology   1   2010

A Novel Potential Role for Gametogenetin-Binding Protein 1 (GGNBP1) in Mitochondrial Morphogenesis During Spermatogenesis in Mice Reviewed

Aihara, Takeshi, Nakamura, Nobuhiro, Honda, Shinji, Hirose, Shigehisa

Biology of Reproduction   80 ( 4 )   762 - 770   2009

Mechanism of development of ionocytes rich in vacuolar-type H+-ATPase in the skin of zebrafish larvae Reviewed

Esaki, Masahiro, Hoshijima, Kazuyuki, Nakamura, Nobuhiro, Munakata, Keijiro, Tanaka, Mikiko, Ookata, Kayoko, Asakawa, Kazuhide, Kawakami, Koichi, Wang, Weiyi, Weinberg, Eric S., Hirose, Shigehisa

Developmental Biology   329 ( 1 )   116 - 129   2009

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane Reviewed

Nakamura, Nobuhiro, Hirose, Shigehisa

Molecular Biology of the Cell   19 ( 5 )   1903 - 1911   2008

MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids Reviewed

Morokuma, Yuri, Nakamura, Nobuhiro, Kato, Akira, Notoya, Michitaka, Yamamoto, Yoko, Sakai, Yasuhiro, Fukuda, Hidekazu, Yamashina, Shohei, Hirata, Yukio, Hirose, Shigehisa

Journal of Biological Chemistry   282 ( 34 )   24806 - 24815   2007

MARCH-V is a novel mitofusin 2-and Drp1-binding protein able to change mitochondrial morphology Reviewed

Nakamura, Nobuhiro, Kimura, Yasuo, Tokuda, Masaki, Honda, Shinji, Hirose, Shigehisa

Embo Reports   7 ( 10 )   1019 - 1022   2006

MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II Reviewed

Fukuda, H, Nakamura, N, Hirose, S

Journal of Biochemistry   139 ( 1 )   137 - 145   2006

Role of C-terminus of Kir7.1 potassium channel in cell-surface expression Reviewed

Tateno, T, Nakamura, N, Hirata, Y, Hirose, S

Cell Biology International   30 ( 3 )   270 - 277   2006

MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking Reviewed

Nakamura, N, Fukuda, H, Kato, A, Hirose, S

Molecular Biology of the Cell   16 ( 4 )   1696 - 1710   2005

腎K+分泌能の発達における内向き整流性K+チャネル(ROMK,Kir7.1)の発現

鈴木 喜郎, 安岡 有紀子, 中村 信大, 広瀬 茂久, 河原 克雅

発達腎研究会誌   12 ( 1 )   13 - 15   2004.9

Expression of the K+ channel Kir7.1 in the developing rat kidney: Role in K+ excretion Reviewed

Suzuki, Y, Yasuoka, Y, Shimohama, T, Nishikitani, M, Nakamura, N, Hirose, S, Kawahara, K

Kidney International   63 ( 3 )   969 - 975   2003

RING finger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica Reviewed

Miyamoto, K, Nakamura, N, Kashiwagi, M, Honda, S, Kato, A, Hasegawa, S, Takei, Y, Hirose, S

European Journal of Biochemistry   269 ( 24 )   6152 - 6161   2002

Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1 Reviewed

Nakamura, N, Suzuki, Y, Ikeda, Y, Notoya, M, Hirose, S

Journal of Biological Chemistry   275 ( 36 )   28276 - 28284   2000

Localization of inward rectifier potassium channel Kir7.1 in the basolateral membrane of distal nephron and collecting duct Reviewed

Ookata, K, Tojo, A, Suzuki, Y, Nakamura, N, Kimura, K, Wilcox, CS, Hirose, S

Journal of the American Society of Nephrology   11 ( 11 )   1987 - 1994   2000

Inward rectifier potassium channel Kir7.1 is highly expressed in the ion-transporting epithelial cells: implication for a functional coupling with Na+,K+-ATPase

Nakamura, N., Suzuki, Y., Sakuta, H., Ookata, K., Kawahara, K., Hirose, S., Suketa, Y., Carafoli, E., Lazdunski, M., Mikoshiba, K., Okada, Y., Wright, EM

Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels   1208   2000

Na,K-ATPaseとの機能共役が期待されるKチャネル(Kir7.1)の細胞局在とTSH応答

中村 信大, 鈴木 喜郎, 池田 雄吾, 大方 香代子, 河原 克雅, 広瀬 茂久

生化学   71 ( 8 )   807 - 807   1999.8

新しいカリウムチャネルKir7.1の遠位側ネフロンの基底膜における局在

大方 香代子, 藤乗 嗣泰, 中村 信大, 鈴木 喜郎, 木村 健二郎, 後藤 淳郎, 藤田 敏郎, 広瀬 茂久

日本腎臓学会誌   41 ( 3 )   275 - 275   1999.5

Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase Reviewed

Nakamura, N., Suzuki, Y., Sakuta, H., Ookata, K., Kawahara, K., Hirose, S.

Biochemical Journal   342 ( 2 )   329 - 336   1999

Identification by differential display of a hypertonicity-inducible inward rectifier potassium channel highly expressed in chloride cells Reviewed

Suzuki, Y, Itakura, M, Kashiwagi, M, Nakamura, N, Matsuki, T, Sakuta, H, Naito, N, Takano, K, Fujita, T, Hirose, S

Journal of Biological Chemistry   274 ( 16 )   11376 - 11382   1999

Molecular characterization and immunohistochemical localization of a bicarbonate transporter highly and predominantly expressed in rat choroid plexus epithelial cells

Fukuda, H, Hirata, T, Nakamura, N, Wakabayashi, S, Romero, MF, Hirose, S

Faseb Journal   19 ( 5 )   A1645 - A1645   2005

Identification of a novel syntaxin-6-binding protein

Nakamura, Nobuhiro, Fukuda, Hidekazu, Kato, Akira, Hirose, Shigehisa

Cell Structure and Function   30   20 - 20   2005

Kdg2, a novel multidomain protein involved in the regulation of recycling endosomal trafficking.

Fukuda, H., Nakamura, N., Kato, A., Hirose, S.

Molecular & Cellular Proteomics   2 ( 9 )   753 - 753   2003

Kdg1, a novel RING-finger membrane protein that localizes in the recycling endosome compartment

Nakamura, N, Fukuda, H, Ikeda, Y, Hirose, S

Molecular Biology of the Cell   13   397A - 398A   2002

Inwardly rectifying potassium channel Kir7.1 is highly expressed in the thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase

N Nakamura, Y Suzuki, H Sakuta, K Ookata, K Kawahara, S Hirose

Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels   Vol. ( No. )   39 - 40   2000

Cloning and properties of a hypertonicity-inducible inward rectifier K+ channel from euryhaline eels

Suzuki, Y, Nakamura, N, Sakuta, H, Takano, K, Fujita, T, Hirose, S, Okada, Y

Cell Volume Regulation   1160   159 - 166   1998

Ubiquitination of syntaxin-6 by the E3 ubiquitin ligase MARCH2

2020.9 

Increased expression of polyamine biosynthetic and catabolic enzymes in alveolar macrophages of Ig-Hepta knockout mice

Hikaru ANDO, Donna Maretta Ariestanti, Shigehisa HIROSE, Nobuhiro NAKAMURA

The 9th TOIN International Symposium on Biomedical Engineering 2014  2014.11 

Early cardiac connexin acts as a Ca2+ hemichannel that regulates heart morphogenesis via NFATc4 activation

Naznin Sultana, Kakon Nag, Akira Kato, Atsushi Kawakami, Koichi Kutsuzawa, Toshihiro Akaike, Shigehisa Hirose, Nobuhiro Nakamura

The ISSCR 12th Annual Meeting  2014.6 

Regulation of mitochondrial morphology by ubiquitination

Nobuhiro Nakamura

International Marine Biotechnology Symposium  2013.5 

USP19 deubiquitinating enzyme regulates stability of TEB4 ubiquitin ligase

Nobuhiro NAKAMURA, Yuki EBISAWA, Shigehisa HIROSE

Joint Meeting of JSDB 45th and JSCB 64th  2012.5 

Regulation of mitochondrial morphology by ubiquitination Invited

Nobuhiro Nakamura

5th Conference of Korean Society for Mitochondrial Research and Medicine  2011.6 

ミトコンドリア形態制御因子に相互作用する新規ユビキチン化酵素 MARCH-V の同定 Invited

中村信大

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Cloning and properties of a hypertonicity-inducible inward rectifier K+ channel from euryhaline eels

Proceedings of the 23rd Taniguchi Foundation Biophysics Symposium  1998 

Kdg1, a novel RING-finger membrane protein that localizes in the recycling endosome compartment.

42nd american society for cell biology annual meeting  2002 

Kdg1, a novel RING-finger membrane protein that localizes in the recycling endosome compartment.

42nd american society for cell biology annual meeting  2002 

Intracellular signaling Mechanism of G-protein coupled receptor ADGRF5

Tomoya Sato, Masako Kato, Humimasa Kubo, Nobuhiro Nakamura

13th Toin International Symposium on Biomedical Engineering  2018.10 

Regulatory mechanism of protein expression of human G-protein coupled recept

2020.9 

Deletion of Adgrf5 causes abnormal glomerular filtration barrier in mice

2020.9 

A549細胞におけるUSP30-AS1の発現制御とUSP30の発現への影響の解析

松本 聖慈, 加藤 真子, 中村 信大

第９４回日本生化学大会  2021.11 

The expression of zebrafish cx36.7 gene is regulated by GATA4 in early heart development

Hisako Miyagi, Ippei Kasajima, Yumiko Tanaka, Keijiro Munakata, Kakon Nag, Naznin Sultana, Shigehisa Hirose, Nobuhiro Nakamura

2014.5 

Emphysema-like symptoms in lungs of Ig-Hepta/GPR116-deficient mice

Donna Maretta Ariestanti, Akira Kato, Tomoya Takahashi, Shigehisa Hirose, Nobuhiro Nakamura

7th international adhesion GPCR workshop  2014.6 

Emphysema-like symptom in Ig-Hepta/Gpr116 knockout mice associated to alveolar macrophage activation

Donna Maretta Ariestanti, Hikaru Ando, Shigehisa Hirose, Nobuhiro Nobuhiro Nakamura

10th Toin International Symposium on Biomedical Engineering  2015.11 

Regulation of cardiac-specific expression of the zebrafish cx36.7 gene

Hisako Miyagi, Kakon Nag, Naznin Sultana, Keijiro Munakata, Shigehisa Hirose, Nobuhiro Nakamura

Toin International Symposium on Biomedical Engineering  2015.11 

A novel mechanism for the regulation of the expression of the mitochondrial deubiquitinating enzyme USP30

Mizuho Muto, Masako Kato, Nobuhiro Nakamura

11th Toin International Symposium on Biomedical Engineering  2016.10 

Adgrf5 deficient mice exhibit bronchial asthma- and fibrosis-like phenotypes

Fumimasa Kubo, Donna Maretta Ariestanti, Souta Oki, Rahmaningsih Mara Sabirin, Ryotarou Demizu, Nobuhiro Nakamura

12th Toin International Symposium on Biomedical Engineering  2017.11 

Adgrf5欠損マウスは気管支喘息および肺線維症様の表現型を現す

久保 文雅, Donna Ariestanti, 沖 颯太, Rahmaningsih Sabirin, 出水 遼太郎, 中村 信大

2017年度生命科学系学会合同年次大会  2017.12 

Gタンパク質共役型受容体ADGRF5の欠損は肺血管内皮細胞における炎症性分子の発現と喘息に似た表現型を誘導する

久保 文雅, Donna Ariestanti, 沖 颯太, 福澤拓, 出水 遼太郎, 佐藤朋哉, Rahmaningsih Sabirin, 広瀬茂久, 中村 信大

第91回日本生化学会大会  2018.9 

Kdg2, a novel multidomain protein involved in the regulation of recycling endosomal trafficking.

HUPO 2nd & IUBMB XIX World Congress  2003 

Kdg2, a novel multidomain protein involved in the regulation of recycling endosomal trafficking.

HUPO 2nd & IUBMB XIX World Congress  2003 

Cardiac expression of zebrafish connexin 36.7 is regulated by GATA4 transcription factor

Hisako Miyagi, Ippei Kasajima, Yumiko Tanaka, Keijiro Munakata, Kakon Nag, Naznin Sultana, Shigehisa Hirose, Nobuhiro Nakamura

8th International Symposium on Biomedical Engineering  2013.10 

The deubiquitinating enzyme USP19 regulates the ERAD pathway by stabilizing the E3 ubiquitin ligases

Kumi Harada, Shigehisa Hirose, Nobuhiro Nakamura

8th International Symposium on Biomedical Engineering  2013.10 

Regulation of the activity of USP19 deubiquitinating enzyme.

Yuki Ebisawa, Nobuhiro Nakamura

8th International Symposium on Biomedical Engineering  2013.10 

Control of mitochondrial morphology by ubiquitination and deubiquitination Invited

Nobuhiro NAKAMURA

8th International Symposium on Biomedical Engineering  2013.10 

Cloning and properties of a hypertonicity-inducible inward rectifier K+ channel from euryhaline eels

Proceedings of the 23rd Taniguchi Foundation Biophysics Symposium  1998 

ゼブラフィッシュの心筋細胞分化の鍵を担う新規コネキシン分子の機能解析

2013.4 - 2014.3

武田科学振興財団  武田科学振興財団ライフサイエンス研究奨励 

中村信大

Roles of the organelle-specific ubiquitination regulators in protein degradation

Grant number：24570209  2012.4 - 2015.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

NAKAMURA Nobuhiro

細胞内Ｃａシグナルのスイッチとなる新発見のコネキシンの生理機能と発現制御機構

Grant number：12F02392  2012.4 - 2015.3

日本学術振興会  科学研究費助成事業  特別研究員奨励費

中村 信大, SULTANA Naznin, SULTANA N.

コネキシンを介したカルシウムシグナリングによる筋原繊維形成の分子機構の解析

2012.4 - 2013.3

倉田記念日立科学技術財団  倉田奨励金 

中村 信大

Cellular role and regulatory mechanism for a novel deubiquitinating enzyme in the endoplasmic reticulum

Grant number：22770123  2010 - 2011

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

NAKAMURA Nobuhiro

Functional characterization of novel proteins involved in mitochondrial dynamics

Grant number：20770156  2008 - 2009

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

NAKAMURA Nobuhiro

細胞内輸送システムに関与する新しい分子の細胞生物学的研究

2004 - 2005

Cell biological study for novel molecules involved in intracellular trafficking

2004 - 2005