Updated on 2026/05/10

写真a

 
TAKAHASHI IKKO
 
Organization
School of Materials and Chemical Technology Specially Appointed Junior Associate Professor
Title
Specially Appointed Junior Associate Professor
Homepage
http://www.ynakajima-cap.mac.titech.ac.jp/index.html
External link

Degree

  • Doctor of Philosophy of Science ( 2017.3   University of Tsukuba )

Research Interests

  • 錯体化学

  • 有機合成化学

  • 有機金属化学

Research Areas

  • Nanotechnology/Materials / Inorganic/coordination chemistry

  • Nanotechnology/Materials / Green sustainable chemistry and environmental chemistry

  • Nanotechnology/Materials / Synthetic organic chemistry

Education

  • University of Tsukuba   Graduate School of Pure and Applied Sciences

    2013.4 - 2017.3

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  • University of Tsukuba   Graduate School of Pure and Applied Sciences

    2011.4 - 2013.3

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  • Utsunomiya University   Faculty of Engineering   Department of Applied Chemistry

    2007.4 - 2011.3

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Research History

  • Institute of Science Tokyo   School of Materials and Chemical Technology   Specially Appointed Assistant Professor

    2026.4

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  • Research Foundation ITSUU Laboratory   Researcher

    2025.4 - 2026.3

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  • RIKEN

    2022.4 - 2025.3

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  • RIKEN

    2019.4 - 2022.3

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  • AIST

    2018.11 - 2019.3

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  • University of Tsukuba

    2018.5 - 2018.10

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  • AIST

    2017.4 - 2018.4

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Professional Memberships

Papers

  • Iron-catalysed direct coupling of organosodium compounds Reviewed International coauthorship International journal

    Ikko Takahashi, Andreu Tortajada, David E. Anderson, Laurean Ilies, Eva Hevia, Sobi Asako

    Nature Synthesis   4 ( 7 )   816 - 825   2025.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s44160-025-00771-1

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  • Halogen–sodium exchange enables efficient access to organosodium compounds Reviewed

    Sobi Asako, Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Kazuhiko Takai

    Communications Chemistry   4 ( 1 )   76   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>With sodium being the most abundant alkali metal on Earth, organosodium compounds are an attractive choice for sustainable chemical synthesis. However, organosodium compounds are rarely used—and are overshadowed by organolithium compounds—because of a lack of convenient and efficient preparation methods. Here we report a halogen–sodium exchange method to prepare a large variety of (hetero)aryl- and alkenylsodium compounds including tri- and tetrasodioarenes, many of them previously inaccessible by other methods. The key discovery is the use of a primary and bulky alkylsodium lacking β-hydrogens, which retards undesired reactions, such as Wurtz–Fittig coupling and β-hydrogen elimination, and enables efficient halogen–sodium exchange. The alkylsodium is readily prepared in situ from neopentyl chloride and an easy-to-handle sodium dispersion. We believe that the efficiency, generality, and convenience of the present method will contribute to the widespread use of organosodium in organic synthesis, ultimately contributing to the development of sustainable organic synthesis by rivalling the currently dominant organolithium reagents.

    DOI： 10.1038/s42004-021-00513-2

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    Other Link： http://www.nature.com/articles/s42004-021-00513-2

  • Continuous Synthesis of Aryl Amines from Phenols Utilizing Integrated Packed‐Bed Flow Systems Reviewed

    Tomohiro Ichitsuka, Ikko Takahashi, Nagatoshi Koumura, Kazuhiko Sato, Shū Kobayashi

    Angewandte Chemie International Edition   59 ( 37 )   15891 - 15896   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/anie.202005109

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.202005109

  • Nickel-Catalyzed Reductive Allyl–Aryl Cross-Electrophile Coupling via Allylic C–F Bond Activation Reviewed

    Takeshi Fujita, Yutaro Kobayashi, Ikko Takahashi, Ryutaro Morioka, Tomohiro Ichitsuka, Junji Ichikawa

    Chemistry — A European Journal   28 ( 2 )   e202103643   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/chem.202103643

    Web of Science

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  • Birch Reduction of Arenes Using Sodium Dispersion and DMI under Mild Conditions Reviewed International journal

    Sobi Asako, Ikko Takahashi, Takashi Kurogi, Yoshiaki Murakami, Laurean Ilies, Kazuhiko Takai

    Chemistry Letters   51 ( 1 )   38 - 40   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    DOI： 10.1246/cl.210546

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  • Halogen–Sodium Exchange Revisited

    Sobi Asako, Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Kazuhiko Takai

    ChemRxiv   2020.5

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    Language：English   Publisher：American Chemical Society (ACS)  

    Sodium is the most abundant alkali metal on Earth. Despite being an attractive choice for sustainable synthesis, organosodium compounds are rarely used in organic synthesis and have been overshadowed to date by organolithium compounds. This situation is largely due to the lack of convenient and efficient methods for the preparation of organosodium compounds. We report herein a halogen–sodium exchange method to prepare a large variety of (hetero)aryl- and alkenylsodium compounds, many of them previously inaccessible by other methods. The key discovery is the use of a bulky alkylsodium lacking a &lt;i&gt;β&lt;/i&gt;-hydrogen, readily prepared in situ from neopentyl chloride and an easy-to-handle sodium dispersion, which retards undesired reactions such as Wurtz–Fittig coupling and &lt;i&gt;β&lt;/i&gt;-hydrogen elimination, and enables efficient halogen-sodium exchange. We believe that the efficiency, generality, and convenience of the present method will open new horizons for the use of organosodium in organic synthesis, ultimately contributing to the development of sustainable chemistry by replacing the currently dominant organolithium reagents.&lt;b&gt;&lt;/b&gt;&lt;/p&gt;

    DOI： 10.26434/chemrxiv.12378104.v1

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  • Brønsted acid-catalysed hydroarylation of unactivated alkynes in a fluoroalcohol–hydrocarbon biphasic system: construction of phenanthrene frameworks Reviewed

    Ikko Takahashi, Takeshi Fujita, Noriaki Shoji, Junji Ichikawa

    Chemical Communications   55 ( 63 )   9267 - 9270   2019.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    <p>Transition metal-free, Brønsted acid-catalysed hydroarylation of unactivated alkynes was achieved in a two-phase solvent system consisting of 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) and cyclohexane.</p>

    DOI： 10.1039/c9cc04152d

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  • Brønsted Acid-catalyzed Tandem Cycloaromatization of Naphthalene-based Bisacetals: Selective Synthesis of ortho-Fused Six-hexagon Benzenoids Reviewed

    Ikko Takahashi, Masaki Hayashi, Takeshi Fujita, Junji Ichikawa

    Chemistry Letters   46 ( 3 )   392 - 394   2017.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    DOI： 10.1246/cl.161122

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  • Facile Synthesis of Polycyclic Aromatic Hydrocarbons: Brønsted Acid Catalyzed Dehydrative Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3‐Hexafluoropropan‐2‐ol Reviewed International journal

    Takeshi Fujita, Ikko Takahashi, Masaki Hayashi, Jingchen Wang, Kohei Fuchibe, Junji Ichikawa

    European Journal of Organic Chemistry   2017 ( 2 )   262 - 265   2016.12

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    The cycloaromatization of aromatic aldehydes and ketones was readily achieved by using a Brønsted acid catalyst in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP). In the presence of a catalytic amount of trifluoromethanesulfonic acid, biaryl‐2‐ylacetaldehydes and 2‐benzylbenzaldehydes underwent sequential intramolecular cationic cyclization and dehydration to afford phenacenes and acenes, respectively. Furthermore, biaryl‐2‐ylacetaldehydes bearing a cyclopentene moiety at the α‐position underwent unprecedented cycloaromatization including ring expansion to afford triphenylenes. HFIP effectively promoted the cyclizations by suppressing side reactions presumably as a result of stabilization of the cationic intermediates.

    DOI： 10.1002/ejoc.201601406

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MISC

Presentations

  • Iron-Catalyzed Direct Coupling of Organosodium Compounds Invited

    Ikko Takahashi, Sobi Asako, Laurean Ilies

    2025.12 

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    Event date： 2025.12

    Presentation type：Oral presentation (invited, special)  

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  • Iron-Catalyzed Coupling Reaction of Organosodium Compounds

    Ikko Takahashi, Sobi Asako, Laurean Ilies

    71st Symposium on Organometallic Chemistry, Japan  2025.9 

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    Event date： 2025.9

    Presentation type：Oral presentation (general)  

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  • Heat of reaction measurement for sodiation and mild Birch reduction using sodium dispersion Invited

    2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • Borane-Accelerated Nucleophilic Phosphination to Access Functionalized Ligands

    Ikko Takahashi

    2026.3 

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    Event date： 2026.3

    Presentation type：Poster presentation  

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  • Iron-Catalyzed Coupling Reactions with Organosodium

    Ikko Takahashi, Andreu Tortajada, David E. Anderson, Laurean Ilies, Eva Hevia, Sobi Asako

    OMCOS 22 

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    Event date： 2025.9

    Presentation type：Poster presentation  

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  • Iron-Catalyzed Direct Coupling of Organosodium Compounds

    Ikko Takahashi, Sobi Asako, Laurean Ilies

    2025.7 

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    Event date： 2025.7

    Presentation type：Poster presentation  

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  • Iron-Catalyzed Coupling of Aryl Organosodium Compounds

    Ikko Takahashi

    FY2023 CSRS Interim Progress Report Meeting  2023.11 

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    Event date： 2023.11

    Language：English   Presentation type：Oral presentation (general)  

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  • Iron-Catalyzed Coupling of Organosodium Compounds

    Ikko Takahashi, Sobi Asako, Laurean Ilies

    日本化学会第103春季年会  2023.3 

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    Event date： 2023.3

    Language：English   Presentation type：Oral presentation (general)  

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  • Sustainable Organic Synthesis Using Sodium Dispersion

    Ikko Takahashi

    第26回異分野交流の夕べ  2023.2 

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    Event date： 2023.2

    Language：English   Presentation type：Poster presentation  

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  • ナトリウム分散体を駆使する有機合成

    高橋一光, 中島啓貴, イリエシュ ラウレアン, 浅子壮美, 髙井和彦

    第11回JACI/GSCシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Poster presentation  

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  • リチウム代替としての金属ナトリウム分散体を用いるサステイナブル有機合成

    浅子壮美, 高橋一光, 中島啓貴, 坪内源, 片山裕美子, 村上吉明, イリエシュ ラウレアン, 髙井和彦

    日本化学会第102春季年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Poster presentation  

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  • Mode-of-Action Analysis of Boron-Containing Compounds that Inhibit Yeast Growth

    Yoko YASHIRODA, Hiromi KIMURA, Mami YOSHIMURA, Masaya USUI, Takashi NIWA, Ikko TAKAHASHI, Nobuko MATAGA, Takamitsu HOSOYA, Laurean ILIES, Minoru YOSHIDA, Charles BOONE

    2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Catalytic Cross-Coupling with Organosodium Compounds

    Sobi Asako, Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Kazuhiko Takai

    環太平洋国際化学会議2021  2021.12 

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    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (general)  

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  • Sustainable Organic Synthesis Using Sodium Dispersion

    Ikko Takahashi, Kazuhiko Takai, Sobi Asako, Laurean Ilies

    FY2021 CSRS Interim Progress Report Meeting  2021.11 

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    Event date： 2021.11

    Language：English   Presentation type：Poster presentation  

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  • リチウム代替としての金属ナトリウム分散体を活用する有機合成

    浅子壮美, 高橋一光, 村上吉明, イリエシュ ラウレアン, 髙井和彦

    日本プロセス化学会2021サマーシンポジウム  2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Organic Synthesis Using Sodium Dispersion

    Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Yoshiaki Murakami, Sobi Asako, Kazuhiko Takai

    2021.3 

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    Event date： 2021.3

    Language：English   Presentation type：Oral presentation (general)  

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  • Mode of Action Analysis of Novel Inhibitors Targeting Ergosterol Biosynthesis

    Yoko Yashiroda, Hiromi Kimura, Mami Yoshimura, Masaya Usui, Takashi Niwa, Ikko Takahashi, Noriko Mataga, Takamitsu Hosoya, Laurean Ilies, Minoru Yoshida, Charles Boone

    日本ケミカルバイオロジー学会第 16 回年会 

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    Event date： 2020.5 - 2020.6

    Language：English   Presentation type：Poster presentation  

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  • 集積型フローリアクターを用いるフェノール類の脱水型アミノ化法

    市塚知宏, 高橋一光, 甲村長利, 佐藤一彦, 小林修

    日本化学会第100春季年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Poster presentation  

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  • Sustainable Organic Synthesis with Sodium Dispersion: Cross-Coupling Reaction and Birch Reduction

    Sobi Asako, Ikko Takahashi, Hirotaka Nakajima, Gen Tsubouchi, Yumiko Katayama, Yoshiaki Murakami, Laurean Ilies, Kazuhiko Takai

    2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Poster presentation  

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  • Preparation of Organosodium Compounds through Halogen–Sodium Exchange

    Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Sobi Asako, Kazuhiko Takai

    2020.3 

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    Event date： 2020.3

    Language：English   Presentation type：Oral presentation (general)  

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  • 集積型フローリアクターを用いるフェノール類の脱水型アミノ化法

    市塚知宏, 高橋一光, 甲村長利, 佐藤一彦, 小林修

    日本化学会第100春季年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Preparation of Organosodium by Halogen–Sodium Exchange

    Ikko Takahashi, Hirotaka Nakajima, Laurean Ilies, Sobi Asako, Kazuhiko Takai

    The 6th CSRS-ITbM Joint Workshop  2020.1 

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    Event date： 2020.1

    Language：English   Presentation type：Poster presentation  

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  • HFIP溶媒を用いたブレンステッド酸触媒による芳香環増環反応

    藤田健志, 高橋一光, 林雅樹, 庄司訓章, 市川淳士

    第113回有機合成シンポジウム  2018.6 

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Nickel-Catalyzed Allylic and Vinylic C–F Bond Activation via β-Fluorine Elimination: Reductive Coupling and Hydroalkenylation

    Takeshi Fujita, Yutaro Kobayashi, Kohei Kanazawa, Yota Watabe, Tomohiro Ichitsuka, Ikko Takahashi, Junji Ichikawa

    第64回有機金属化学討論会  2017.9 

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    Event date： 2017.9

    Language：English   Presentation type：Poster presentation  

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  • ブレンステッド酸触媒による不活性アルキンの分子内ヒドロアリール化：フェナセン類の高効率合成

    高橋一光, 藤田健志, 市川淳士

    日本化学会第97春季年会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • ブレンステッド酸触媒によるカチオン環化反応を用いたタンデム型芳香環増環法

    林雅樹, 高橋一光, 藤田健志, 市川淳士

    第6回CSJ化学フェスタ2016  2016.11 

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    Event date： 2016.11

    Language：Japanese   Presentation type：Poster presentation  

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  • 含フッ素アルコールを利用したブレンステッド酸触媒による多環式芳香族炭化水素の合成

    高橋一光, 王晶晨, 藤田健志, 市川淳士

    第38回フッ素化学討論会  2015.9 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • ブレンステッド酸触媒による脱水型芳香環増環反応：多環式芳香族炭化水素の簡便合成

    王晶晨, 高橋一光, 藤田健志, 市川淳士

    日本化学会第95春季年会  2015.3 

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    Event date： 2015.3

    Language：Japanese   Presentation type：Poster presentation  

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  • Brønsted Acid-Catalyzed Dehydrative Cycloaromatization Promoted in 1,1,1,3,3,3-Hexafluoropropan-2-ol

    Ikko Takahashi, Jingchen Wang, Takeshi Fujita, Junji Ichikawa

    International Conference on Fluorine Chemistry 2014  2014.5 

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    Event date： 2014.5

    Language：English   Presentation type：Poster presentation  

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  • 含フッ素アルコールを溶媒としたブレンステッド酸触媒による脱水芳香環増環反応

    高橋一光, 王晶晨, 藤田健志, 市川淳士

    第36回フッ素化学討論会  2013.10 

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    Event date： 2013.10

    Language：Japanese   Presentation type：Poster presentation  

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  • (ビアリール-2-イル)アセトアルデヒドの分子内環 化–脱水芳香族化:多環式芳香族炭化水素の簡便合成

    高橋一光, 藤田健志, 市川淳士

    日本化学会第 93 春季年会  2013.3 

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    Event date： 2013.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • A Facile Synthesis of Phenacenes via Intramolecular Dehydrative Cycloaromatization of (Biaryl-2-yl)acetaldehyde

    Ikko Takahashi, Takeshi Fujita, Junji Ichikawa

    3rd International Symposium on Creation of Functional Materials  2012.12 

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    Event date： 2012.12

    Language：English   Presentation type：Poster presentation  

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  • Dihydroanthracene-Based Dication as Organic Two-Electron Oxidant

    Ikko Takahashi, Masahiko Shinjo, Takeshi Fujita, Junji Ichikawa

    2nd International Symposium on Creation of Functional Materials  2012.2 

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    Event date： 2012.2

    Language：English   Presentation type：Poster presentation  

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  • 不定形高次多環式芳香族炭化水素の合成法：TfOH-in-HFIP触媒によるタンデム型芳香環増環法

    林雅樹, 高橋一光, 藤田健志, 市川淳士

    第73回有機合成化学協会関東支部シンポジウム  2017.5 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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Industrial property rights

  • HFO-1234yfを用いるテトラフルオロトリエン、（トリフルオロメチル）アレーン、および（トリフルオロメチル）シクロブテンの合成法

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    Application no：特願2022-035313  Date applied：2022.3

    Rights holder：市川淳士

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  • 1,1,1,3,3,3-ヘキサフルオロプロパン-2-オールと脂肪族炭化水素系溶媒を用いた二相系反応媒体

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    Application no：特願2017-039790  Date applied：2017.3

    Announcement no：特開6839356 

    Rights holder：市川淳士

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Awards

  • 理研栄峰賞

    2026.3   理化学研究所   鉄触媒による有機ナトリウム化合物を用いたカップリング反応の開発

    高橋一光, イリエシュ ラウレアン, 浅子壮美

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  • JSPC Award for Excellence

    2025.7  

    Ikko Takahashi, Sobi Asako, Laurean Ilies

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    Award type：Award from Japanese society, conference, symposium, etc. 

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  • 環境資源科学研究センター奨励賞

    2022.4   環境資源科学研究センター   金属ナトリウム分散体を利用するサステイナブル有機合成

    高橋一光, 浅子壮美

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  • JSPC Award for Excellence

    2021.6  

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    Award type：Award from Japanese society, conference, symposium, etc. 

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  • 第26回異分野交流の夕べ ポスター賞

    2023.2   理化学研究所  

    高橋一光

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Research Projects

  • ナトリウム元素を活用するポストリチウム有機合成

    Grant number：26K08439  2026.4 - 2029.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    高橋 一光

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    Grant amount：\6240000 （ Direct Cost: \4800000 、 Indirect Cost：\1440000 ）

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  • 鉄触媒と有機ナトリウム化合物で切り拓くサステイナブル精密有機合成

    Grant number：24K17716  2024.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

    高橋 一光

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • Exploring organosodium chemistry with Earth-abundant metal catalysis International coauthorship

    2022.4 - 2025.3

    RIKEN  Special Postdoctoral Researcher 

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    Grant type：Competitive

    Grant amount：\4000000 （ Direct Cost: \4000000 ）

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  • Exploring Organosodium Chemistry with Organocatalysis and Earth-Abundant Metals

    Grant number：22K14719  2022.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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Teaching Experience

  • 修了生によるオムニバス講座

    2022.6 Institution：筑波大学大学院 数理物質科学研究科

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Social Activities

Media Coverage

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