Updated on 2026/06/30

写真a

 
LI HONGMIN
 
Organization
School of Life Science and Technology Researcher
Title
Researcher
Other name(s)
Li Hongmin
Profile

I am a researcher at the Sato Laboratory for Biomedical Data Science, School of Life Science and Technology, Institute of Science Tokyo. I am also a guest researcher at the Frith Lab, The University of Tokyo, and the founder of AlphaScience Lab, an initiative focused on expertise-guided, auditable, and responsible AI-assisted scientific discovery.

My current research focuses on AI-automated scientific workflows, AI research and evaluation, bioinformatics, and AI for Science. I am interested in building computational systems that help automate, audit, and accelerate scientific discovery.

Recent research includes audit-constrained protocols for targeted tests of LLM reasoning, minimal models separating shortcut-rule transition from cross-family OOD failure, controlled counterexamples to strong proxy-based explanations of OOD performance, and FastUMAP, a scalable dimensionality-reduction method based on bipartite landmark sampling. I also work on ID3 as a task-general input-data differentiable framework. While biomolecular sequence design is one current application, the core idea is meant to extend to general task settings where inputs, objectives, and evaluation signals can be made differentiable and auditable.

External link

Research Interests

  • Large language models

  • AI for Science

  • Bioinformatics

  • AI-automated scientific workflows

Research Areas

  • Informatics / Mathematical informatics  / Machine Learning

  • Informatics / Life, health and medical informatics  / Bioinformatics, AI for Science

Education

  • University of Tsukuba   Graduate School of Systems and Information Engineering

    2019.4 - 2022.3

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  • University of Tsukuba   Graduate School of Systems and Information Engineering

    2017.4 - 2019.3

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  • University of Tsukuba   Graduate School of Systems and Information Engineering   Computer science

    2016.10 - 2017.3

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    Notes: Research student

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  • 寧夏大学   物理电气工程学群   电子信息工程学類

    2011.9 - 2015.7

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    Country: China

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  • ウランチャブ市集寧第一中学(高校)

    2008.9 - 2011.5

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Research History

  • The University of Tokyo   Frith Lab   Guest Researcher

    2026.4

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    Notes:Collaborative research on bioinformatics and biological sequence analysis

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  • Institute of Science Tokyo   School of Life Science and Technology, Sato Laboratory for Biomedical Data Science   Researcher

    2026.4

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    Notes:Research on AI-automated scientific workflows, AI for Science, and bioinformatics

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  • The University of Tokyo   Graduate School of Frontier Sciences Department of Computational Biology   Project researcher

    2023.5 - 2026.3

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  • HAOMO.AI   Machine learning engineer

    2022.11 - 2023.4

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  • The University of Tokyo   Graduate School of Frontier Sciences Department of Computational Biology   Project researcher

    2022.4 - 2022.10

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Papers

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Presentations

  • A novel large scale spectral clustering

    Li Hongmin

    The 2021 International Collaborative Workshop of RUB-UGA-UT, 3rd Edition - Recent Trends in Computer Science and Artificial Intelligence (CollaboTICS 2021)  2021.12 

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    Event date: 2021.12

    Presentation type:Symposium, workshop panel (public)  

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  • Large scale spectral clustering using landmarks based on hubness Invited International conference

    Hongmin Li

    International Symposium on “Digital Science Now” in association with the G20 Ministerial Meeting on Trade and Digital Economy  2019.6 

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    Language:English   Presentation type:Poster presentation  

    File: hubs spectral clustering.pdf

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Awards

  • Google Cloud TPU Builders Award

    2026.6   Google.org Research Credits Program Team / Google Cloud   USD 5,500 in GCP credits for TPU-based AI and scientific workflow experiments

    Hongmin Li

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  • Second prize of the first AETA Earthquake Prediction AI Algorithm Competition

    2020.11   Peking University Shenzhen Graduate School  

    LI HONGMIN

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  • Best paper award

    2018.10   CBDCom 2018   Large Scale Spectral Clustering Using Sparse Representation Based on Hubness

    Xiucai Ye, Hongmin Li, Tetsuya Sakurai, Zhi Liu

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Research Projects

  • Development of an Input-Data Differentiable Integrated Framework (ID3) for Biomolecular Sequence Design

    Grant number:26K21370  2026.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Hongmin Li

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    Authorship:Principal investigator 

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  • Development of a Large-Scale Language Model Integrating RNA Sequences and Text

    Grant number:24K20890  2024.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

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  • Google Grant: Input Data Differentiable Designer: A Novel ML Algorithm for Biological Sequence Optimization $30,000

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