Updated on 2026/03/26

写真a

 
SUN YUCHEN
 
Organization
School of Science Assistant Professor
Title
Assistant Professor
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Degree

  • Ph. D. ( 2023.9   The University of Tokyo )

Research Interests

  • Analytical chemsitry

  • Organic geochemistry

  • Isotope ecology

  • Biogeochemistry

  • Amino acids

Research Areas

  • Natural Science / Biogeosciences

  • Nanotechnology/Materials / Analytical chemistry

  • Environmental Science/Agriculture Science / Environmental dynamic analysis

Education

  • The University of Tokyo   Graduate School of Science   Department of Earth and Planetary Science

    2018.9 - 2023.9

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    Country： Japan

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  • The University of Tokyo   School of Science   Department of Chemistry

    2016.9 - 2018.8

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    Country： Japan

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  • Nanjing University

    2014.9 - 2016.8

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    Country： China

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Research History

  • Institute of Science Tokyo   Department of Earth and Planetary Sciences   Assistant Professor

    2026.3

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  • University of California, Santa Cruz   Ocean Sciences Department   Postdoctoral Researcher

    2024.2 - 2026.1

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    Country：United States

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  • Japan Agency for Marine-Earth Science and Technology   Biogeochemistry Research Center   External Researcher

    2023.10 - 2024.1

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  • Japan Society for the Promotion of Science   Research Fellow (PD)

    2023.10 - 2024.1

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  • Japan Society for the Promotion of Science   Research Fellow (DC1)

    2021.4 - 2023.9

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  • The University of Tokyo   University of Tokyo Fellowship

    2020.9 - 2021.3

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  • Japan Agency for Marine-Earth Science and Technology   Research Assistant

    2019.5 - 2020.9

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Professional Memberships

  • Geochemical Society

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  • Geochemical Society of Japan

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  • Association for the Sciences of Limnology and Oceanography

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  • The Japanese Association of Organic Geochemists

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  • Japan Geoscience Union

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Papers

  • Carbon isotopic changes of 16 proteinogenic amino acids during trophic transfer in a cultured marine consumer Reviewed

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    Progress in Earth and Planetary Science   13   9   2026.1

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： 10.1186/s40645-026-00795-x

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  • Chromatographic isolation for performing enantiomer-specific radiocarbon analysis (ESRA): first method development for individual L- and D-amino acids Reviewed

    Thomas M. Blattmann, Yuchen Sun, Nanako O. Ogawa, Yoshinori Takano, Negar Haghipour, Naoto F. Ishikawa, Timothy I. Eglinton, Naohiko Ohkouchi

    Progress in Earth and Planetary Science   12   84   2025.9

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40645-025-00764-w

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  • Enantiomer-specific stable carbon and nitrogen isotopic analyses of underivatized individual L- and D‑amino acids by HPLC + HPLC separation and nano-EA/IRMS Reviewed

    Yuchen Sun, Thomas M. Blattmann, Yoshinori Takano, Nanako O. Ogawa, Yuta Isaji, Naoto F. Ishikawa, Naohiko Ohkouchi

    Analytical Chemistry   96 ( 47 )   18664 - 18671   2024.11

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.analchem.4c02851

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  • Application of a porous graphitic carbon column to carbon and nitrogen isotope analysis of underivatized individual amino acids using high‐performance liquid chromatography coupled with elemental analyzer/isotope ratio mass spectrometry Reviewed

    Yuchen Sun, Nanako O. Ogawa, Naoto F. Ishikawa, Thomas M. Blattmann, Yoshinori Takano, Naohiko Ohkouchi

    Rapid Communications in Mass Spectrometry   37 ( 17 )   2023.8

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Rationale

    Isolation of underivatized amino acids (AAs) using high‐performance liquid chromatography (HPLC) is becoming a popular method for carbon (δ13C) and nitrogen isotope (δ15N) analyses of AAs because of the high analytical precision and for performing dual‐isotope analysis. However, some AAs in natural samples, especially small, hydrophilic AAs, are not suitably separated using reversed‐phase columns (e.g., C18) and ion‐exchange columns (e.g., Primesep A).

    Methods

    We developed a new method for HPLC using a porous graphitic carbon column for the separation of nine hydrophilic AAs. After purification, δ13C and δ15N values of AAs were determined using elemental analyzer/isotope ratio mass spectrometry (EA/IRMS). We demonstrated the application of this method by determining δ13C and δ15N values of individual hydrophilic AAs in a biological sample, the muscle of blue mackerel (Scomber australasicus).

    Results

    Chromatographically, the baseline separation of hydrophilic AAs was achieved in both the standard mixture and the biological sample. We confirmed that δ13C and δ15N values of AA standards remained unchanged during the whole experimental procedure. The δ13C values of AAs in mackerel muscle are also in good agreement with the values obtained using another verified method for δ13C analysis.

    Conclusions

    The good separation performance of hydrophilic AAs and the reliability of δ13C and δ15N analyses of individual AAs using the porous graphite column offer a significant advantage over conventional settings. We suggest that, in the future, the HPLC × EA/IRMS method can be used for reliable δ13C and δ15N analyses of AAs in natural samples.

    DOI： 10.1002/rcm.9602

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  • Integrative assessment of amino acid nitrogen isotopic composition in biological tissue samples determined by GC/C/IRMS, LC × EA/IRMS, and LC × GC/C/IRMS Reviewed

    Naoto F. Ishikawa, Nanako O. Ogawa, Yuchen Sun, Yoshito Chikaraishi, Yoshinori Takano, Naohiko Ohkouchi

    Limnology and Oceanography: Methods   20 ( 9 )   531 - 542   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/lom3.10502

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  • A method for stable carbon isotope measurement of underivatized individual amino acids by multi‐dimensional high‐performance liquid chromatography and elemental analyzer/isotope ratio mass spectrometry Reviewed

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Hodaka Kawahata, Yoshinori Takano, Naohiko Ohkouchi

    Rapid Communications in Mass Spectrometry   34 ( 20 )   2020.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/rcm.8885

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/rcm.8885

  • Pressure-induced esterification reaction between phosphoric acid and methanol Reviewed

    Yuchen Sun, Chikako Fujimoto, Hiroyuki Kagi

    Chemistry Letters   49 ( 8 )   885 - 887   2020.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.200289

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MISC

  • Microbial Reworking of Organic Matter in Marine Sediments Revealed by Carbon Isotopic Compositions of Individual Amino Acids

    孫 語辰, 小川 奈々子, 石川 尚人, 黒田 潤一郎, 高野 淑識, 大河内 直彦

    2022年度日本地球化学会第69回年会講演要旨集   2022.9

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  • High-precision compound-specific carbon isotopic analysis of underivatized amino acids using a multi-dimensional-HPLC and nano-EA/IRMS

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Hodaka Kawahata, Yoshinori Takano, Naohiko Ohkouchi

    EGU General Assembly 2020 Abstract Book   2020.3

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    Publisher：Copernicus GmbH  

    <p>We have developed an analytical method for the precise δ<sup>13</sup>C measurement of individual amino acid using a multi-dimensional high-performance liquid chromatography (HPLC) and a nano-scale elemental analyzer/isotope ratio mass spectrometry (EA/IRMS). Although this method is time-consuming, it can offer higher precision and accuracy than does the conventional analytical method such as GC/C/IRMS, because the derivatization of amino acids is not required. A reversed-phase column (CAPCELL PAK C18, Shiseido, Japan) and a mixed-mode column (Primesep A, SIELC Technologies, U.S.A.) were applied for the HPLC (Agilent Technologies, U.S.A.) with a charged aerosol detector (Thermo Fisher Scientific, U.S.A.) (Ishikawa et al., 2018). We conducted the isolation of underivatized amino acids in a standard mixture containing 15 proteinogenic amino acids (Gly, Ala, Glu, Arg, Val, Pro, Met, Tyr, Ile, Leu, Phe, Thr, His, Asp, Ser), and confirmed that all these amino acids were successfully isolated. Each collected amino acid was filtered through a 0.45 μm membrane filter (Pall, U.S.A.) and washed with diethyl ether to remove hydrophobic impurities. The δ<sup>13</sup>C values of these amino acids before and after the separation and purification were consistent, which proved that the whole experimental procedure did not change the δ<sup>13</sup>C values of amino acids. We applied this method to several aquatic organisms. The results show that the δ<sup>13</sup>C values of amino acids vary as large as 30‰ with Gly being most enriched in <sup>13</sup>C.</p><p>Reference</p><p>Ishikawa et al., (2018) <em>Anal. Chem.</em>, 90, 20, 12035-12041.</p><div><div><div> </div></div></div>

    DOI： 10.5194/egusphere-egu2020-1601

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Presentations

  • Quantitative recovery of dissolved organic nitrogen? Exploring a new method integrating ultrafiltration with C18 and PPL solid-phase extraction resins

    Lingyu Ma, Yuchen Sun, Stephanie Christensen, Matthew D. McCarthy

    ASLO Aquatic Sciences Meeting 2025  2025.3 

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    Presentation type：Poster presentation  

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  • Radiocarbon Analysis of Individual Amino Acids to Understand the Cycling of Nitrogen in Marine Dissolved Organic Matter

    Yuchen Sun, Lingyu Ma, Taylor A.B. Broek, Brett D. Walker, Stephanie Christensen, Matthew D. McCarthy

    ASLO Aquatic Sciences Meeting 2025  2025.3 

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    Language：English   Presentation type：Oral presentation (general)  

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  • 高圧下での有機化学反応からみた氷惑星における分子進化の可能性

    鍵裕之, 高橋修也, 三村耕一, 篠崎彩子, 小松一生, 藤本千賀子, 孫語辰

    第59回高圧討論会  2018.11 

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  • Determination of compound-specific stable carbon isotopic compositions of individual amino acids: A potential tool for environmental study

    Yuchen Sun, Hodaka Kawahata, Naoto F. Ishikawa, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    The Univ. of Tokyo-Tongji Univ. Joint Workshop on Geoscience  2019.9 

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    Language：English   Presentation type：Oral presentation (general)  

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  • A new method for high-precision measurement for stable carbon isotope of amino acids

    Yuchen Sun

    International Symposium on Isotope Physiology, Ecology, and Geochemistry 2019  2019.6 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Study of aquatic food web based on high-precision stable carbon isotopic measurement of individual amino acids

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    2020.3 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Pressure-induced esterification reaction between phosphoric acid and methanol: a possibility of prebiotic formation of alkyl phosphate and phospholipid at high pressure

    Yuchen Sun, Chikako Fujimoto, Hiroyuki Kagi

    JpGU-AGU Joint Meeting 2020  2020.7 

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    Language：English   Presentation type：Oral presentation (general)  

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  • High-precision compound-specific carbon isotopic analysis of underivatized amino acids using a multi-dimensional-HPLC and nano-EA/IRMS

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Hodaka Kawahata, Yoshinori Takano, Naohiko Ohkouchi

    EGU General Assembly 2020  2020.5 

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    Language：English   Presentation type：Poster presentation  

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  • A new assessment of amino acid stable carbon isotope compositions in marine organisms: implications for food web studies

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    The 69th Annual Meeting of the Ecological Society of Japan (ESJ69)  2022.3 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Development and applications of a liquid chromatography method for the compound- and enantiomer-specific stable carbon isotope analysis of amino acids in environmental samples

    Yuchen Sun, Naoto F. Ishikawa, Thomas M. Blattmann, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    Ocean Science Meeting 2022  2022.3 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Measurements and applications of compound-specific C, N, and S isotope ratios with HPLC purification system and ultra-sensitive EA/IRMS

    Nanako O. Ogawa, Naoto F. Ishikawa, Yuchen Sun, Yoshinori Takano, Naohiko Ohkouchi

    International Symposium on Isotope Physiology, Ecology, and Geochemistry 2022  2022.8 

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    Presentation type：Oral presentation (general)  

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  • Enantiomer-specific carbon isotope analysis of amino acids: New method and perspectives

    Yuchen Sun, Thomas M. Blattmann, Naoto F. Ishikawa, Nanako O. Ogawa, Yoshinori Takano, Naohiko Ohkouchi

    International Symposium on Isotope Physiology, Ecology, and Geochemistry 2022  2022.8 

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    Language：English   Presentation type：Oral presentation (general)  

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  • A new method for enantiomer-specific carbon and nitrogen isotope analyses of underivatized amino acids

    Yuchen Sun, Thomas M. Blattmann, Naoto F. Ishikawa, Nanako O. Ogawa, Junichiro Kuroda, Yoshinori Takano, Naohiko Ohkouchi

    JpGU-AGU Joint Meeting 2023  2023.5 

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    Presentation type：Poster presentation  

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  • Microbial Reworking of Organic Matter in Marine Sediments Revealed by Carbon Isotopic Compositions of Individual Amino Acids

    Yuchen Sun, Nanako O. Ogawa, Naoto F. Ishikawa, Junichiro Kuroda, Yoshinori Takano, Naohiko Ohkouchi

    The 69th Annual Meeting of the Geochemical Society of Japan  2022.9 

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  • Carbon isotopic compositions of 16 proteinogenic amino acids and their enantiomers for biogeochemical study

    Yuchen Sun, Nanako O. Ogawa, Yoshinori Takano, Naoto F. Ishikawa, Yuta Isaji, Thomas M. Blattmann, Junrichiro Kuroda, Hodaka Kawahata, Naohiko Ohkouchi

    JpGU Annual Meeting 2024  2024.5 

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  • New method and perspectives of amino acid enantiomer-specific isotope analysis

    Yuchen Sun, Thomas M. Blattmann, Nanako O. Ogawa, Naoto F. Ishikawa, Yoshinori Takano, Naohiko Ohkouchi

    The 40th Symposium in Organic Geochemistry  2023.9 

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    Language：English  

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Awards

  • Taguchi Prize

    2025.8   The Japanese Association of Organic Geochemists  

    Yuchen Sun

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  • Best Student Presentation Award

    2023.8   The Japanese Association of Organic Geochemists  

    Yuchen Sun

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  • Top Cited Articles 2021

    2022.3   Wiley  

    Yuchen Sun, Naoto F. Ishikawa, Nanako O. Ogawa, Hodaka Kawahata, Yoshinori Takano, Naohiko Ohkouchi

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  • Best English Presentation Award

    2022.3   The Ecological Society of Japan  

    Yuchen Sun

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  • Global Science Course Scholarship Award

    2016.9   University of Tokyo  

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Research Projects

  • Study of marine carbon cycle based on stable carbon isotopic compositions of amino acids in marine sediments

    Grant number：21J20841  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Grant amount：\2200000 （ Direct Cost: \2200000 ）

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Academic Activities

  • Fundamental Research

    Role(s)： Peer review

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  • Biogeosciences

    Role(s)： Peer review

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  • Rapid Communications in Mass Spectrometry

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  • Analytical Chemistry

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  • Progress in Earth and Planetary Science

    Role(s)： Peer review

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    Type：Peer review 

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