Updated on 2026/07/04

写真a

 
TERASAKA NAOHIRO
 
Organization
Institute of Future Science Earth-Life Science Institute Specially Appointed Associate Professor
Title
Specially Appointed Associate Professor
Homepage
https://nterasaka.wixsite.com/terasaka-lab/en
External link

Degree

  • 博士（理学） ( 東京大学 )

Research Interests

  • 遺伝暗号

  • ペプチド

  • リボザイム

  • RNA

  • ケミカルバイオロジー

  • 分子進化工学

  • 合成生物学

  • リボソーム

  • カプシドタンパク質

  • tRNA

Research Areas

  • Life Science / Evolutionary biology

  • Nanotechnology/Materials / Bio chemistry

Education

  • The University of Tokyo   Graduate School of Science   Department of Chemistry

    2012.4 - 2015.3

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  • The University of Tokyo   The Graduate School of Engineering   Department of Chemistry and Biotechnology

    2010.4 - 2012.3

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  • The University of Tokyo   The Faculty of Engineering   Department of Chemistry and Biotechnology

    2008.4 - 2010.3

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  • The University of Tokyo   College of Arts and Sciences

    2006.4 - 2008.3

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  • 駒場東邦高等学校

    2003.4 - 2006.3

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Research History

  • 国立研究開発法人 科学技術振興機構 創発的研究支援事業研究者

    2025.4

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  • Institute of Science Tokyo   Earth-Life Science Institute, Institute of Future Science   Specially Appointed Associate Professor

    2024.10

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  • Tokyo Institute of Technology   International Research Frontiers Initiative, Earth-Life Science Institute   Specially Appointed Associated Professor

    2022.6 - 2024.9

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    Country：Japan

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  • The University of Tokyo   Graduate School of Science Department of Chemistry   Assistant Professor

    2022.4 - 2022.6

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  • 国立研究開発法人 科学技術振興機構 さきがけ研究 「細胞の動的高次構造体」 研究者

    2021.10 - 2025.3

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  • The University of Tokyo   Graduate School of Science, Department of Chemistry   Project Assistant Professor

    2018.6 - 2022.3

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  • ETH Zurich   Postdoctoral Associate

    2015.4 - 2018.5

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  • ヒューマン・フロンティア・サイエンス・プログラム (HFSP) 長期フェロー

    2015.4 - 2018.3

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  • 日本学術振興会 特別研究員（DC1）

    2012.4 - 2015.3

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Professional Memberships

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Papers

  • An engineered closed-shell, two-component, 480-subunit nucleocapsid Reviewed International coauthorship International journal

    Mikail D. Levasseur, Naohiro Terasaka, Angela Steinauer, Stephan Tetter, Sara Pfister, Beat H. Meier, Donald Hilvert

    Proceedings of the National Academy of Sciences   123 ( 22 )   2026.5

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：National Academy of Sciences  

    Self-assembling protein cages are valuable nanoscale containers for biotechnology and medical applications. Two-component systems are especially attractive due to their potential for functional complexity. In this study, we demonstrate that the subunits of the 240-subunit nucleocapsid NC-4, which was previously evolved to package and protect its encoding mRNA, can be split into two fragments without disrupting cage assembly or structure, generating a two-component, 480-subunit capsid. This modification introduces additional termini on the cage’s exterior surface, creating opportunities for functionalization. We exploited these new sites by genetically appending peptide and protein tags to the exterior surface of split NC-4 (spNC-4), enabling site-specific glycosylation via posttranslational modification and cell-specific delivery by targeted antibody recruitment. Our findings broaden the utility of the NC-4 nucleocapsid. By extension, splitting related protein compartments that bind diverse cargoes could offer a robust platform for biotechnological applications requiring simultaneous encapsulation and customizable surface modification.

    DOI： 10.1073/pnas.2530090123

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  • Artificial initiation codons and engineered initiator tRNAs enable N-terminal noncanonical amino acid incorporation in intact cell-free translation systems

    Haruyuki Furukawa, Yasunori Okamoto, Naohiro Terasaka

    bioRxiv   2026.5

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    Authorship：Corresponding author  

    DOI： 10.64898/2026.05.24.725928

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  • In Vitro Evolution of the Adenosine A 2A Receptor Based on an Antagonist Binding Using a Ribosome Display Reviewed International journal

    Genki Fukasawa, Yuma Matsuoka, Duy Phuoc Tran, Haruka Nishigaki, Keisuke Fukunaga, Takayoshi Watanabe, Tomohiro Doura, Naohiro Terasaka, Ako Kagawa, Takeshi Murata, Akio Kitao, Shigeki Kiyonaka, Tomoaki Matsuura

    Journal of the American Chemical Society   148 ( 10 )   11415 - 11423   2026.3

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.6c02372

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  • Cargo-Directed Assembly of Nonviral Nucleocapsid with Controlled Size Reviewed International coauthorship International journal

    Kenya Tajima, Yusuke Sakai, Naohiro Terasaka

    ACS Synthetic Biology   15 ( 3 )   1178 - 1186   2026.2

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acssynbio.5c00881

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  • Efficient cell-free evolution of RNA polymerases by droplet microfluidics

    Naohiro Terasaka, Taro Furubayashi, Kenya Tajima, Hiroyuki Noji

    bioRxiv   2026.2

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    Authorship：Lead author,　Corresponding author  

    DOI： 10.64898/2026.02.23.707346

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  • Boosted cell-free gene expression for robust signal readout from a single-copy DNA template in microdroplets International journal

    Taro Furubayashi, Naohiro Terasaka, Kenya Tajima, Hiroyuki Noji

    bioRxiv   2026.2

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  • A Nonviral Neo‐Nucleocapsid for Cell‐Specific RNA Delivery Developed by Pseudo‐Cyclic Peptide Grafting and Directed Evolution Reviewed International journal

    Daiki Kanayama, Naohiro Terasaka, Kazuki Kato, Sae Okazaki, Hiroaki Suga

    Angewandte Chemie International Edition   2026.2

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ange.202519027

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  • Optimization of Malonyl Coenzyme A Biosensors in a Reconstituted Cell-Free System for Detecting Acetyl-CoA Carboxylase Activity Reviewed International journal

    Shohei Ito, Shota Nishikawa, Naohiro Terasaka, Kosuke Fujishima

    ACS Synthetic Biology   14 ( 8 )   3245 - 3251   2025.7

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acssynbio.5c00361

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  • De Novo Peptides That Induce the Liquid–Liquid Phase Separation of α-Synuclein Reviewed International journal

    Tatsuya Ikenoue, Masatomo So, Naohiro Terasaka, Wei-En Huang, Yasushi Kawata, Yohei Miyanoiri, Kiyoto Kamagata, Hiroaki Suga

    Journal of the American Chemical Society   147 ( 27 )   24113 - 24126   2025.6

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.5c08019

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  • RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease Reviewed International coauthorship International journal

    Marina Kawai, Tika R. Malla, H. T. Henry Chan, Anthony Tumber, Lennart Brewitz, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Akane Kawamura, Christopher J. Schofield, Fernanda Duarte, Hiroaki Suga

    RSC Chemical Biology   6 ( 7 )   1089 - 1099   2025.5

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    Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    The ribosomal synthesis of a helical peptide library containing structurally constrained cyclic β-amino acid at every third position and its application for the RaPID selection against SARS-CoV-2 main protease (Mpro) inhibitors.

    DOI： 10.1039/d5cb00021a

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  • A versatile method of ribosomal synthesis of peptides containing long chain fatty acids at the N-terminus Reviewed

    Hiroki Murakami, Naohiro Terasaka, Haruo Aikawa, Hiroaki Suga

    Bulletin of the Chemical Society of Japan   98 ( 4 )   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    The N-terminal modification of peptides and proteins with long chain fatty acids (LCFAs) plays an important role in their cellular bioactivity and localization. Such modifications are generally carried out by specific enzymes in a post-translation manner, and therefore an alteration of the N-terminal modifying groups requires either engineering the enzymes or their unusual intrinsic promiscuity. Here we report a versatile method using an approach of in vitro ribosomal synthesis of peptides containing various long fatty acids at the N-terminus. We charged Gly on an initiator tRNA by flexizyme, and then the free N-amino group was chemically acylated with myristoyl chloride and applied to the ribosomal synthesis of a myristoyl-peptide according to the designated mRNA template sequence. This approach turns out to be applicable for a wide array of not only initiator amino acids but also LCFAs. To this end, we have demonstrated the ribosomal synthesis of the Myrcludex B, an inhibitor peptide of hepatitis B virus infection containing the myristoyl group, and its variants containing other LCFA groups.

    DOI： 10.1093/bulcsj/uoaf027

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    Other Link： https://academic.oup.com/bcsj/article-pdf/98/4/uoaf027/62775731/uoaf027.pdf

  • Diversity Scale of Library Matters: Impact of mRNA Library Diversity Scales on the Discovery of Macrocyclic Peptides Targeting a Protein by the RaPID System Reviewed

    Jinxuan Zhao, Yi Li, Naohiro Terasaka, Haruo Aikawa, Hiroaki Suga

    ACS Central Science   11 ( 3 )   431 - 440   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acscentsci.4c01021

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  • An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation Reviewed International journal

    Wei Lu, Naohiro Terasaka, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Hiroaki Suga

    Nucleic Acids Research   52 ( 7 )   3938 - 3949   2024.3

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    In the hypothetical RNA world, ribozymes could have acted as modern aminoacyl-tRNA synthetases (ARSs) to charge tRNAs, thus giving rise to the peptide synthesis along with the evolution of a primitive translation apparatus. We previously reported a T-boxzyme, Tx2.1, which selectively charges initiator tRNA with N-biotinyl-phenylalanine (BioPhe) in situ in a Flexible In-vitro Translation (FIT) system to produce BioPhe-initiating peptides. Here, we performed in vitro selection of elongation-capable T-boxzymes (elT-boxzymes), using para-azido-l-phenylalanine (PheAZ) as an acyl-donor. We implemented a new strategy to enrich elT-boxzyme-tRNA conjugates that self-aminoacylated on the 3′-terminus selectively. One of them, elT32, can charge PheAZ onto tRNA in trans in response to its cognate anticodon. Further evolution of elT32 resulted in elT49, with enhanced aminoacylation activity. We have demonstrated the translation of a PheAZ-containing peptide in an elT-boxzyme-integrated FIT system, revealing that elT-boxzymes are able to generate the PheAZ-tRNA in response to the cognate anticodon in situ of a custom-made translation system. This study, together with Tx2.1, illustrates a scenario where a series of ribozymes could have overseen aminoacylation and co-evolved with a primitive RNA-based translation system.

    DOI： 10.1093/nar/gkae151

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  • Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease Reviewed International coauthorship International journal

    Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, Martin A Walsh, Akane Kawamura, Christopher J Schofield, Takayuki Katoh, Hiroaki Suga

    Bulletin of the Chemical Society of Japan   97 ( 5 )   2024.3

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Due to their constrained conformations, cyclic β2,3-amino acids (cβAA) are key building blocks that can fold peptides into compact and rigid structures, improving peptidase resistance and binding affinity to target proteins, due to their constrained conformations. Although the translation efficiency of cβAAs is generally low, our engineered tRNA, referred to as tRNAPro1E2, enabled efficient incorporation of cβAAs into peptide libraries using the flexible in vitro translation (FIT) system. Here we report on the design and application of a macrocyclic peptide library incorporating 3 kinds of cβAAs: (1R,2S)-2-aminocyclopentane carboxylic acid (β1), (1S,2S)-2-aminocyclohexane carboxylic acid (β2), and (1R,2R)-2-aminocyclopentane carboxylic acid. This library was applied to an in vitro selection against the SARS-CoV-2 main protease (Mpro). The resultant peptides, BM3 and BM7, bearing one β2 and two β1, exhibited potent inhibitory activities with IC50 values of 40 and 20 nM, respectively. BM3 and BM7 also showed remarkable serum stability with half-lives of 48 and >168 h, respectively. Notably, BM3A and BM7A, wherein the cβAAs were substituted with alanine, lost their inhibitory activities against Mpro and displayed substantially shorter serum half-lives. This observation underscores the significant contribution of cβAA to the activity and stability of peptides. Overall, our results highlight the potential of cβAA in generating potent and highly stable macrocyclic peptides with drug-like properties.

    DOI： 10.1093/bulcsj/uoae018

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    Other Link： https://academic.oup.com/bcsj/article-pdf/97/5/uoae018/57922858/uoae018.pdf

  • De Novo Single-Stranded RNA-Binding Peptides Discovered by Codon-Restricted mRNA Display Reviewed International journal

    Shota Nishikawa, Hidenori Watanabe, Naohiro Terasaka, Takayuki Katoh, Kosuke Fujishima

    Biomacromolecules   25 ( 1 )   355 - 365   2023.12

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.biomac.3c01024

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  • MET‐Activating Ubiquitin Multimers Reviewed International journal

    Naoya Kawakami, Hiroki Sato, Naohiro Terasaka, Kunio Matsumoto, Hiroaki Suga

    Angewandte Chemie International Edition   62 ( 36 )   2023.7

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Receptor tyrosine kinases (RTKs) are generally activated through their dimerization and/or oligomerization induced by their cognate ligands, and one such RTK hepatocyte growth factor (HGF) receptor, known as MET, plays an important role in tissue regeneration. Here we show the development of ubiquitin (Ub)‐based protein ligand multimers, referred to as U‐bodies, which act as surrogate agonists for MET and are derived from MET‐binding macrocyclic peptides. Monomeric Ub constructs (U‐body) were first generated by genetic implantation of a macrocyclic peptide pharmacophore into a structural loop of Ub (lasso‐grafting) and subsequent optimization of its flanking spacer sequences via mRNA display. Such U‐body constructs exhibit potent binding affinity to MET, thermal stability, and proteolytic stability. The U‐body constructs also partially/fully inhibited or enhanced HGF‐induced MET‐phosphorylation. Their multimerization to dimeric, tetrameric, and octameric U‐bodies linked by an appropriate peptide linker yielded potent MET activation activity and downstream cell proliferation‐promoting activity. This work suggests that lasso‐grafting of macrocycles to Ub is an effective approach to devising protein‐based artificial RTK agonists and it can be useful in the development of a new class of biologics for various therapeutic applications.

    DOI： 10.1002/anie.202307157

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  • In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease Reviewed International coauthorship International journal

    Takashi Miura, Tika R. Malla, C. David Owen, Anthony Tumber, Lennart Brewitz, Michael A. McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin A. Walsh, Akane Kawamura, Christopher J. Schofield, Hiroaki Suga

    Nature Chemistry   15 ( 7 )   998 - 1005   2023.5

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incorporation of γ-amino acids into peptides is challenging. Here we report how a selection campaign employing a non-canonical peptide library containing cyclic γ2,4-amino acids resulted in the discovery of very potent inhibitors of the SARS-CoV-2 main protease (Mpro). Two kinds of cyclic γ2,4-amino acids, cis-3-aminocyclobutane carboxylic acid (γ1) and (1R,3S)-3-aminocyclopentane carboxylic acid (γ2), were ribosomally introduced into a library of thioether-macrocyclic peptides. One resultant potent Mpro inhibitor (half-maximal inhibitory concentration = 50 nM), GM4, comprising 13 residues with γ1 at the fourth position, manifests a 5.2 nM dissociation constant. An Mpro:GM4 complex crystal structure reveals the intact inhibitor spans the substrate binding cleft. The γ1 interacts with the S1′ catalytic subsite and contributes to a 12-fold increase in proteolytic stability compared to its alanine-substituted variant. Knowledge of interactions between GM4 and Mpro enabled production of a variant with a 5-fold increase in potency.

    DOI： 10.1038/s41557-023-01205-1

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    Other Link： https://www.nature.com/articles/s41557-023-01205-1

  • De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors Reviewed International coauthorship International journal

    Alexander A. Vinogradov, Yue Zhang, Keisuke Hamada, Jun Shi Chang, Chikako Okada, Hirotaka Nishimura, Naohiro Terasaka, Yuki Goto, Kazuhiro Ogata, Toru Sengoku, Hiroyasu Onaka, Hiroaki Suga

    Journal of the American Chemical Society   144 ( 44 )   20332 - 20341   2022.10

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.2c07937

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  • Macrocyclic Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy Reviewed International coauthorship International journal

    Leonardo Puppulin, Daiki Kanayama, Naohiro Terasaka, Katsuya Sakai, Noriyuki Kodera, Kenichi Umeda, Ayumi Sumino, Arin Marchesi, Wei Weilin, Hideo Tanaka, Takeshi Fukuma, Hiroaki Suga, Kunio Matsumoto, Mikihiro Shibata

    ACS Applied Materials & Interfaces   13 ( 46 )   54817 - 54829   2021.11

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsami.1c17708

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  • De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist Reviewed International coauthorship International journal

    Yamato Komatsu, Naohiro Terasaka, Katsuya Sakai, Emiko Mihara, Risa Wakabayashi, Kunio Matsumoto, Donald Hilvert, Junichi Takagi, Hiroaki Suga

    iScience   24 ( 11 )   103302 - 103302   2021.11

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.isci.2021.103302

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  • Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein Reviewed International coauthorship International journal

    Stephan Tetter, Naohiro Terasaka, Angela Steinauer, Richard J. Bingham, Sam Clark, Andrew J. P. Scott, Nikesh Patel, Marc Leibundgut, Emma Wroblewski, Nenad Ban, Peter G. Stockley, Reidun Twarock, Donald Hilvert

    Science   372 ( 6547 )   1220 - 1224   2021.6

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Association for the Advancement of Science (AAAS)  

    Revolution in an RNA-packaging capsid

    Artificial nucleocapsid proteins, which could be analogous to those used by viruses to package their genomes, are a promising way to protect and deliver RNAs. Using an escalating challenge by nucleases, Tetter et al. evolved a protein that forms multimeric, spherical cages into a highly efficient capsid that selectively packages its own encoding RNA. Cryo–electron microscopy of the final design and intermediates revealed a stepwise expansion in size, enabled by destabilizing amino acid substitutions and a domain swap that results in a change of oligomerization interfaces for the base units of the cage. In addition to altering the protein, directed evolution resulted in changes to the encoding RNA structure that enabled efficient uptake versus other cellular RNAs.

    Science , abg2822, this issue p. 1220

    DOI： 10.1126/science.abg2822

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    Other Link： https://www.science.org/doi/pdf/10.1126/science.abg2822

  • Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy Reviewed International journal

    Daisuke Hazama, Yizhen Yin, Yoji Murata, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga, Takashi Matozaki

    Cell Chemical Biology   27 ( 9 )   1181 - 1191.e7   2020.9

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.chembiol.2020.06.008

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  • An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch Reviewed International journal

    Satoshi Ishida, Naohiro Terasaka, Takayuki Katoh, Hiroaki Suga

    Nature Chemical Biology   16 ( 6 )   702 - 709   2020.3

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41589-020-0500-6

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    Other Link： http://www.nature.com/articles/s41589-020-0500-6

  • Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies Reviewed International coauthorship International journal

    Hanne L. P. Tytgat, Chia-wei Lin, Mikail D. Levasseur, Markus B. Tomek, Christoph Rutschmann, Jacqueline Mock, Nora Liebscher, Naohiro Terasaka, Yusuke Azuma, Michael Wetter, Martin F. Bachmann, Donald Hilvert, Markus Aebi, Timothy G. Keys

    Nature Communications   10 ( 1 )   2019.11

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains limited. Established bacterial glycoengineering platforms require secretion of the acceptor protein to the periplasmic space and preassembly of the oligosaccharide substrate as a lipid-linked precursor, limiting access to protein and glycan substrates respectively. Here, we circumvent these bottlenecks by developing a facile glycoengineering platform that operates in the bacterial cytoplasm. The Glycoli platform leverages a recently discovered site-specific polypeptide glycosyltransferase together with variable glycosyltransferase modules to synthesize defined glycans, of bacterial or mammalian origin, directly onto recombinant proteins in the E. coli cytoplasm. We exploit the cytoplasmic localization of this glycoengineering platform to generate a variety of multivalent glycostructures, including self-assembling nanomaterials bearing hundreds of copies of the glycan epitope. This work establishes cytoplasmic glycoengineering as a powerful platform for producing glycoprotein structures with diverse future biomedical applications.

    DOI： 10.1038/s41467-019-13283-2

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    Other Link： https://www.nature.com/articles/s41467-019-13283-2

  • Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1 Reviewed International coauthorship International journal

    Sophie T. PhuongDung Tran, Christopher J. Hipolito, Hiroyuki Suzuki, Rudy Xie, Huynh Dam Kim Tuyen, Peter ten Dijke, Naohiro Terasaka, Yuki Goto, Hiroaki Suga, Mitsuyasu Kato

    Biochemical and Biophysical Research Communications   516 ( 2 )   445 - 450   2019.8

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbrc.2019.06.035

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  • Laboratory evolution of virus-like nucleocapsids from nonviral protein cages Reviewed International coauthorship International journal

    Naohiro Terasaka, Yusuke Azuma, Donald Hilvert

    Proceedings of the National Academy of Sciences   115 ( 21 )   5432 - 5437   2018.5

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Proceedings of the National Academy of Sciences  

    DOI： 10.1073/pnas.1800527115

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  • Modular Protein Cages for Size-Selective RNA Packaging in Vivo Reviewed International coauthorship International journal

    Yusuke Azuma, Thomas G. W. Edwardson, Naohiro Terasaka, Donald Hilvert

    Journal of the American Chemical Society   140 ( 2 )   566 - 569   2018.1

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.7b10798

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  • A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX Reviewed International journal

    Naohiro Terasaka, Kazuki Futai, Takayuki Katoh, Hiroaki Suga

    RNA   22 ( 12 )   1918 - 1928   2016.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Cold Spring Harbor Laboratory  

    RNA aptamers are structured motifs that bind to specific molecules. A growing number of RNAs bearing aptamer elements, whose functions are modulated by direct binding of metabolites, have been found in living cells. Recent studies have suggested that more small RNAs binding to metabolites likely exist and may be involved in diverse cellular processes. However, conventional methods are not necessarily suitable for the discovery of such RNA aptamer elements in small RNAs with lengths ranging from 50 to 200 nucleotides, due to the far more abundant tRNAs in this size range. Here, we describe a new in vitro selection method to uncover naturally occurring small RNAs capable of binding to a ligand of interest, referred to as small RNA transcriptomic SELEX (smaRt-SELEX). By means of this method, we identified a motif in human precursor microRNA 125a (hsa-pre-miR-125a) that interacts with folic acid. Mutation studies revealed that the terminal loop region of hsa-pre-miR-125a is important for this binding interaction. This method has potential for the discovery of new RNA aptamer elements or catalytic motifs in biological small RNA fractions.

    DOI： 10.1261/rna.057737.116

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  • tRid, an enabling method to isolate previously inaccessible small RNA fractions Reviewed International journal

    Kazuki Futai, Naohiro Terasaka, Takayuki Katoh, Hiroaki Suga

    Methods   106   105 - 111   2016.8

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ymeth.2016.04.033

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  • Recent Developments of Engineered Translational Machineries for the Incorporation of Non-Canonical Amino Acids into Polypeptides Reviewed International journal

    Naohiro Terasaka, Yoshihiko Iwane, Anna-Skrollan Geiermann, Yuki Goto, Hiroaki Suga

    International Journal of Molecular Sciences   16 ( 3 )   6513 - 6531   2015.3

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Genetic code expansion and reprogramming methodologies allow us to incorporate non-canonical amino acids (ncAAs) bearing various functional groups, such as fluorescent groups, bioorthogonal functional groups, and post-translational modifications, into a desired position or multiple positions in polypeptides both in vitro and in vivo. In order to efficiently incorporate a wide range of ncAAs, several methodologies have been developed, such as orthogonal aminoacyl-tRNA-synthetase (AARS)–tRNA pairs, aminoacylation ribozymes, frame-shift suppression of quadruplet codons, and engineered ribosomes. More recently, it has been reported that an engineered translation system specifically utilizes an artificially built genetic code and functions orthogonally to naturally occurring counterpart. In this review we summarize recent advances in the field of ribosomal polypeptide synthesis containing ncAAs.

    DOI： 10.3390/ijms16036513

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  • An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center Reviewed International journal

    Naohiro Terasaka, Gosuke Hayashi, Takayuki Katoh, Hiroaki Suga

    Nature Chemical Biology   10 ( 7 )   555 - 557   2014.6

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/nchembio.1549

    PubMed

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    Other Link： http://www.nature.com/articles/nchembio.1549

  • Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides Reviewed International journal

    Naohiro Terasaka, Hiroaki Suga

    Chemistry Letters   43 ( 1 )   11 - 19   2013.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.130910

    Web of Science

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  • The RNA origin of transfer RNA aminoacylation and beyond Reviewed International journal

    Hiroaki Suga, Gosuke Hayashi, Naohiro Terasaka

    Philosophical Transactions of the Royal Society B: Biological Sciences   366 ( 1580 )   2959 - 2964   2011.10

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    Aminoacylation of tRNA is an essential event in the translation system. Although in the modern system protein enzymes play the sole role in tRNA aminoacylation, in the primitive translation system RNA molecules could have catalysed aminoacylation onto tRNA or tRNA-like molecules. Even though such RNA enzymes so far are not identified from known organisms, in vitro selection has generated such RNA catalysts from a pool of random RNA sequences. Among them, a set of RNA sequences, referred to as flexizymes (Fxs), discovered in our laboratory are able to charge amino acids onto tRNAs. Significantly, Fxs allow us to charge a wide variety of amino acids, including those that are non-proteinogenic, onto tRNAs bearing any desired anticodons, and thus enable us to reprogramme the genetic code at our will. This article summarizes the evolutionary history of Fxs and also the most recent advances in manipulating a translation system by integration with Fxs.

    DOI： 10.1098/rstb.2011.0137

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    Other Link： https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2011.0137

  • Crystallization and preliminary X-ray diffraction analysis of an archaeal tRNA-modification enzyme, TiaS, complexed with tRNAIle2and ATP Reviewed International journal

    Takuo Osawa, Hideko Inanaga, Satoshi Kimura, Naohiro Terasaka, Tsutomu Suzuki, Tomoyuki Numata

    Acta Crystallographica Section F Structural Biology and Crystallization Communications   67 ( 11 )   1414 - 1416   2011.10

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    Publishing type：Research paper (scientific journal)   Publisher：International Union of Crystallography (IUCr)  

    DOI： 10.1107/s1744309111034890

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  • Structural basis of tRNA agmatinylation essential for AUA codon decoding Reviewed International journal

    Takuo Osawa, Satoshi Kimura, Naohiro Terasaka, Hideko Inanaga, Tsutomu Suzuki, Tomoyuki Numata

    Nature Structural & Molecular Biology   18 ( 11 )   1275 - 1280   2011.10

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    DOI： 10.1038/nsmb.2144

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    Other Link： http://www.nature.com/articles/nsmb.2144

  • Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS Reviewed International journal

    Naohiro Terasaka, Satoshi Kimura, Takuo Osawa, Tomoyuki Numata, Tsutomu Suzuki

    Nature Structural & Molecular Biology   18 ( 11 )   1268 - 1274   2011.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/nsmb.2121

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    Other Link： http://www.nature.com/articles/nsmb.2121

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Books

  • 生体分子の実験的進化工学

    寺坂尚紘（ Role： Contributor）

    生体の科学 Vol.76 No.2 2025年 04月号 特集 AIにより加速する生体分子デザイン  2025.4 

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  • 特殊環状ペプチドライブラリの構築と薬剤候補探索

    川合茉利奈, 井上澄香, 寺坂尚紘, 菅裕明

    CSJ Current Review 生体分子と疾患ーヘルスサイエンスの切り札としての化学ー  2021.8 

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  • 試験管内分子進化法によるバイオマテリアル創成

    寺坂尚紘, 菅裕明（ Role： Joint author）

    日本核酸化学会 核酸科学ハンドブック  2020.12 

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    Responsible for pages：201  

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  • Applications of aminoacylation ribozymes that recognize the 3’-end of tRNA

    寺坂 尚紘

    Springer  2017 

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  • 遺伝暗号のリプログラミングによる特殊ペプチドライブラリーの構築と生理活性ペプチド探索

    寺坂尚紘, 山岸祐介, 菅裕明

    実験医学増刊号 Vol.29 No.7, 75-82  2011 

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MISC

  • 実験室内進化で迫る原始ウイルス形成過程 Invited Reviewed

    寺坂尚紘

    Viva Origino   52 ( 1 )   2024.5

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  • 細菌タンパク質をウイルス模倣ヌクレオカプシドに分子進化させる

    寺坂尚紘

    生化学   94 ( 5 )   2022

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  • 細菌タンパクを用いたウイルス様構造とパッケージング機構の進化

    寺坂 尚紘, Donald Hilver

    Science に載った日本人研究者 2021   34   2022

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  • リボソーム翻訳系と修飾酵素を用いた非リボソームペプチド類似体の合成

    寺坂 尚紘

    ファルマシア   57 ( 6 )   543 - 543   2021

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    Language：Japanese   Publisher：公益社団法人 日本薬学会  

    複数の抗生物質に耐性を示す多剤耐性菌による感染症は世界中で問題になっている．さらに，認可される抗生物質は過去数十年で減少しており，新たな抗生物質探索方法の開発は急務である．ペプチド性天然物である非リボソームペプチド(NRPs)は多彩な構造を有し，生理活性が期待できる．例えばバンコマイシンやダプトマイシンなどの抗菌NRPsが発見されており，NRPs類似化合物のライブラリーは，新規抗生物質の探索に有用であると考えられる．しかし，NRPs合成酵素は高い基質選択性を持つ巨大複合体であるため，酵素改変による多様性の高いNRPsライブラリー構築は未だ困難である．<br>一方で，リボソーム翻訳系翻訳後修飾ペプチド(RiPPs)は，DNAから転写・翻訳されたペプチドに翻訳後修飾酵素が化学修飾を導入することで合成される．RiPPsの翻訳後修飾酵素の多くは基質許容性が高く，さらに縮重塩基を持つDNAを用いることで，高多様性ペプチドライブラリーの構築が可能である．本稿では，ハイスループットスクリーニング系に適用可能なRiPPs合成系を用いて，抗菌活性を持つNRPs類似化合物を合成するアプローチに関する論文を紹介する．<br>なお，本稿は下記の文献に基づいて，その研究成果を紹介するものである.<br>1) Niquille D. L. et al., Nat. Chem., 10, 282-287(2018)．<br>2) Zhao X. et al., Cell. Chem. Biol., 27, 1262-1271(2020)．<br>3) Li Y. X. et al., Nat. Commun., 9, 3273(2018)．<br>4) Urban J. H. et al., Nat. Commun., 8, 1500(2017)．

    DOI： 10.14894/faruawpsj.57.6_543

    CiNii Research

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Presentations

  • Engineering and Evolution of Protein Capsids that Package Their Own mRNAs Invited International conference

    Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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    Event date： 2026.11

    Language：English   Presentation type：Oral presentation (invited, special)  

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  • Machine Learning-Driven Cell-Free Evolution of a Genetically Encoded Lactate Biosensor with Reduced pH Sensitivity International coauthorship International conference

    Zhengyang Luo, Yusuke Nasu, Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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    Event date： 2026.11

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  • Diversification of Protein Cage Assembly by Topological Rearrangement International conference

    Masahiro Noji, Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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  • Topological Design Dictates the Evolutionary Trajectory of Artificial Nucleocapsid Assembly International conference

    Hualin Li, Osamu Kikko, Takeru Kagawa, Kazuki Ishihara, Kenya Tajima, Tomoaki Matsuura, Tomoyuki Numata, Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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    Event date： 2026.11

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  • Modulation of Cargos Packaged into Nonviral Nucleocapsid toward Cargo-Directed Morphological Control International coauthorship International conference

    Kenya Tajima, Yusuke Sakai, Hualin Li, Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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  • Development of a Microfluidic Cell-free Directed Evolution System for Membrane-Active Peptides International conference

    Wenke Cao, Naohiro Terasaka

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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  • Structural Design and Cell-Free Synthesis of α-Helical Chimeric Nanopores Containing Non-Natural Amino Acids International conference

    Mana Sato, Zugui Peng, Daisuke Sato, Naohiro Terasaka, Izuru Kawamura, Tomoaki Matsuura, Ryuji Kawano

    International Conference on Biophysics and Biomedical Sciences 2026  2026.11 

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  • Artificial initiation codons and engineered tRNAs enable N-terminal noncanonical amino acid incorporation in intact cell-free translation systems and purification-free binder analysis

    Haruyuki Furukawa, Yasunori Okamoto, Naohiro Terasaka

    2026.11 

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  • Detection of Acetyl-CoA Carboxylase Activity Using a Reconstituted Cell-Free Protein Synthesis System and Microdroplets

    2026.7 

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  • 無細胞タンパク質高速スクリーニングによるRNAポリメラーゼ改変体の創出

    寺坂尚紘

    東京科学大学（Science Tokyo） 新技術説明会  2026.6 

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  • 進化分子工学による機能性生体分子複合体の創出 Invited

    寺坂尚紘

    第3回PRI鈴木梅太郎シンポジウム  2026.6 

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    Event date： 2026.6

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • 再構成型無細胞タンパク質合成系と極小ドロップレットを用いたア セチル CoA カルボキシラーゼ活性の検出

    伊藤昇平, 西川将太, 寺坂尚紘, 藤島皓介

    DROPLET2026  2026.6 

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  • 高精度液滴ペアマッチングの提案と検討

    工藤凜和, 寺坂尚紘, 平松光太郎, 那須雄介, 磯崎瑛宏

    DROPLET2026  2026.6 

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  • 改変無細胞翻訳系を用いたドロップレット内一分子DNAからのタンパク質翻訳とタンパク質進化工学への応用 Invited

    寺坂尚紘

    DROPLET2026  2026.6 

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    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • マイクロ流路デバイスを用いた 無細胞タンパク質スクリーニング

    寺坂尚紘

    日本薬学会第146年会  2026.3 

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    Event date： 2026.3

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  • Laboratory evolution of virus-like ribonucleoprotein complexes Invited International conference

    International Symposium of Life-Nonlife Transition Boundaries Between Life and Nonlife  2026.3 

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  • 油中水滴を用いた無細胞酵素進化システム Invited

    寺坂尚紘

    日本農芸化学会2026年度京都大会  2026.3 

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    Event date： 2026.3

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • Directed Evolution of RNA-Encapsulating Protein Nucleocapsids with Distinct Sizes International conference

    Hualin Li, Tomoyuki Numata, Tomoaki Matsuura, Naohiro Terasaka

    14th ELSI International Symposium  2026.1 

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  • Innovative Lactate Indicators Developed Using High-Throughput Techniques International coauthorship International conference

    Zhengyang Luo, Yusuke Nasu, Tomoaki Matsuura, Naohiro Terasaka

    14th ELSI International Symposium  2026.1 

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  • Laboratory evolution of membrane associated peptides International conference

    Cao Wenke, Tomoaki Matsuura, Naohiro Terasaka

    14th ELSI International Symposium  2026.1 

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  • Functionalization and size control of laboratory evolved artificial nucleocapsids International conference

    2025.12 

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    Event date： 2025.12

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  • Cell-free evolution of fluorescent protein-based lactate biosensors International coauthorship International conference

    Zhengyang Luo, Yusuke Nasu, Naohiro Terasaka

    2025.12 

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  • Directed Evolution of Nonviral Nucleocapsids with Enlarged Structures International conference

    Hualin LI, Naohiro Terasaka

    2025.12 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Cell-free evolution of anti-microbial peptide using microfluidics International conference

    Wenke Cao, Naohiro Terasaka

    2025.12 

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  • 再構成型無細胞タンパク質合成系を用いたマロニルCoAバイオセンサーの最適化とアセチルCoAカルボキシラーゼ活性の検出

    伊藤 昇平, 西川 将太, 寺坂 尚紘, 藤島 皓介

    第48回日本分子生物学会年会  2025.12 

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  • Structural and biochemical analyses of T-box riboswitch-based ribozyme catalyzing tRNA aminoacylation International conference

    Takeru Kagawa, Kouhei Abe, Naohiro Terasaka, Hiroaki Suga, Tomoyuki Numata

    The 19th Conference of Asian Crystallographic Association 2025  2025.12 

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  • 参照粒子を利用した液滴マイクロ流路における 高精度ペアマッチング法に関する検討

    工藤凜和, 寺坂尚紘, 平松光太郎, 那須雄介, 磯崎瑛宏

    化学とマイクロ・ナノシステム学会第52回研究会（CHEMINAS 52）  2025.11 

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  • In vitro assembly of a nonviral protein capsid and its morphological control mediated by versatile cargos International coauthorship

    Kenya Tajima, Yusuke Sakai, Naohiro Terasaka

    The 63rd Annual Meeting of the Biophysical Society of Japan  2025.9 

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    Event date： 2025.9

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  • Functionalization and structural diversification of artificial nucleocapsids by laboratory evolution International conference

    The 63rd Annual Meeting of the Biophysical Society of Japan  2025.9 

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  • ウイルス模倣ヌクレオカプシドの構造多様化と機能化

    寺坂尚紘

    「細胞を創る」研究会18.0  2025.9 

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  • 無細胞翻訳バイオセンサーとエマルジョン液滴を用いたCO2固定酵素の指向性進化

    伊藤昇平, 西川将太, 寺坂尚紘, 藤島皓介

    「細胞を創る」研究会18.0  2025.9 

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  • A HIGH-ACCURACY PAIR MATCHING METHOD FOR DROPLET MICROFLUIDICS WITH TWO-STATE MEASUREMENT POINTS International conference

    Akihiro Isozaki, Yusuke Nasu, Naohiro Terasaka

    IEEE MEMS 2025  2025.1 

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  • Structural expansion of nonviral nucleocapsids by laboratory evolution International conference

    Hualin Li, Naohiro Terasaka

    13th ELSI International Symposium 2025  2025.1 

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  • Directed evolution of CO2 fixation enzyme using cell free expression biosensor and droplet sorting

    Shohei Ito, Naohiro Terasaka, Shota Nishikawa, Kosuke Fujishima

    The 47th Annual Meeting of the Molecular Biology Society of Japan  2024.11 

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  • Establishment of a platform for the development of novel xCT inhibitors

    Ryosuke Zaitsu, Yuto Ohno, Fumiya K Sano, Tatsuki Tanaka, Takaaki A Kobayashi, Yoshiaki Kise, Tsukasa Kusakizako, Haruo Aikawa, Naohiro Terasaka, Kazumasa Oda, Shojiro Kitajima, Hiroaki Suga, Osamu Nureki

    The 47th Annual Meeting of the Molecular Biology Society of Japan  2024.11 

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  • A Simple peptide tag inducing protein condensates in cell-free translation system International conference

    Naohiro Terasaka

    4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS2024)  2024.11 

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  • How does library size affect the biding kinetics of hits in RaPID selection? International conference

    Haruo Aikawa, Jinxuan Zhao, Yi Li, Naohiro Terasaka, Hiroaki Suga

    4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS2024)  2024.11 

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  • 進化工学による機能性分子の創出と生命起源研究への展開 Invited

    寺坂尚紘

    第11回 バイオ関連化学シンポジウム 若手フォーラム  2024.9 

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  • Tandem artificial nucleocapsid to package longer RNA genome and expand protein architectures International conference

    Hualin Li, Naohiro Terasaka

    21st IUPAB Congress 2024  2024.6 

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  • In vitro assembly of protein capsule and cargo molecules into a virus-like particle International conference

    Kenya Tajima, Yusuke Sakai, Naohiro Terasaka

    21st IUPAB Congress 2024  2024.6 

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  • In vitro packaging of various cargo molecules into a non-viral protein cage

    Kenya Tajima, Yusuke Sakai, Naohiro Terasaka

    The 24th Annual Meeting of the Protein Science Society of Japan  2024.6 

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  • Protein evolution by cell-free translation system in water-in-oil droplet

    Naohiro Terasaka

    The 24th Annual Meeting of the Protein Science Society of Japan  2024.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Fusion of U-body and a self-assembling protein produces a MET agonist International conference

    Yuki Kashiwa, Katsuya Sakai, Naohiro Terasaka, Haruo Aikawa, Kunio Matsumoto, Hiroaki Suga

    The 3rd International Symposium on Biofunctional Chemistry  2024.4 

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  • Directed evolution of virus-like ribonucleoprotein particles Invited International conference

    Naohiro Terasaka

    The 3rd International Symposium on Biofunctional Chemistry  2024.4 

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    Language：English   Presentation type：Oral presentation (invited, special)  

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  • Development of nonviral nucleocapsid by laboratory evolution and its biotechnological application Invited

    Naohiro Terasaka

    The 144th Annual Meeting of the Pharmaceutical Society of Japan  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • Directed evolution of nonviral ribonucleoproteins to virus-like particles Invited International conference

    Naohiro Terasaka

    Joint CO world & 12th ELSI Symposium  2024.1 

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    Event date： 2024.1

    Language：English   Presentation type：Oral presentation (invited, special)  

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  • In vitro assembly of protein capsule and cargo molecules into a virus-like particle International conference

    2024.1 

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  • Assembly of virus-like architectures directed by cargo molecules

    Kenya Tajima, Naohiro Terasaka

    The 61st Annual Meeting of the Biophysical Society of Japan  2023.11 

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  • SURFACE FUNCTIONALIZATION OF A VIRUS-LIKE ARCHITECTURE WITH A PEPTIDE TAG

    Daiki Kanayama, Naohiro Terasaka, Hiroaki Suga

    The 60th Japanese Peptide Symposium  2023.11 

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  • CHEMICAL MODIFICATION AT THE N-TERMINUS OF AMINOACYL-tRNA AND ITS APPLICATION TO IN VITRO TRANSLATION SYSTEM

    Hiroki Murakami, Naohiro Terasaka, Haruo Aikawa, Hiroaki Suga

    The 60th Japanese Peptide Symposium  2023.11 

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  • Discovery of de novo macrocyclic peptide specifically binding to Siglec- 10 among Siglec family proteins

    Wei-En Huang, Naohiro Terasaka, Yuma Matsuzaki, Haruo Aikawa, Hiroaki Suga

    The 60th Japanese Peptide Symposium  2023.11 

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  • Development of Bifunctional antibody with immune checkpoint inhibitory effect using Lasso-grafting

    Jinxuan ZHAO, Naohiro Terasaka, Yoji Murata, Hiroaki Suga

    The 60th Japanese Peptide Symposium  2023.11 

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  • T-boxリボスイッチを基盤としたアミノアシル化リボザイムの構造と機能 International coauthorship

    香川尊, 安部紘平, 石田啓, Wei Lu, 菅裕明, 寺坂尚紘, Adrian Ferré-D'Amar, 沼田倫征

    日本結晶学会年会  2023.10 

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  • Development of bifunctional antibody with immune checkpoint inhibitory effect using Lasso-grafting International conference

    Jinxuan ZHAO, Naohiro Terasaka, Yoji Murata, Hiroaki Suga

    13th International Peptide Symposium  2023.10 

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  • Nucleic acids templated assembly of artificial virus-like particles

    Kenya Tajima, Yusuke Sakai, ○Naohiro Terasaka

    Japanese Society For Cell Synthesis Research annual meeting 16.0  2023.9 

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    Event date： 2023.9

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  • Engineering and evolution of self-assembling proteins mimicking virus particles

    Naohiro Terasaka

    RIKEN Seminar  2023.7 

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    Event date： 2023.7

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  • Development of aminoacylation ribozymes capable of peptide elongation in one-pot in vitro translation International conference

    Wei Lu, Naohiro Terasaka, Hiroaki Suga

    IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023  2023.6 

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    Event date： 2023.6

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  • 自己集合タンパク質に立脚した受容体チロシンキナーゼ 人工活性化剤の開発

    柏勇希, 酒井克也, 寺坂尚紘, 相川春夫, 松本邦夫, 菅裕明

    日本ケミカルバイオロジー学会第17回年会  2023.5 

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  • RNAとタンパク質の協奏的進化による機能性複合体の創成 Invited

    寺坂尚紘

    自然科学研究機構 生命創成探究センター (ExCELLS)、分子科学研究所 (IMS)研究会「生命の分子システムの理解に向けて何を創れば良いか？」  2023.5 

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  • Laboratory evolution of virus-like protein capsules

    Naohiro Terasaka, Kenya Tajima

    The 47th Annual Meeting of The Society for the Study of the Origin and Evolution of Life Japan  2023.3 

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  • 環状γ-アミノ酸含有ペプチドを用いたSARS-CoV-2メインプロテアーゼ阻害剤のスクリーニング International coauthorship

    三浦 敬, Malla Tika, Owen David, Tumber Anthony, Brewitz Lennar, McDonough Michael, Salah Eidarus, 寺坂 尚紘, 加藤 敬行, Lukacik Petra, Strain-Damerell Claire, Mikolajek Halina, Walsh Martin, Kawamura Akane, Schofield Christopher, 菅 裕明

    日本薬学会第143年会  2023.3 

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  • 環状βアミノ酸を含む新規ヘリカルペプチド薬剤候補探索 International coauthorship

    川合 茉利奈, 加藤 敬行, Malla Tika, Tumber Anthony, Brewitz Lennar, McDonough Michael, Salah Eidraus, 寺坂 尚紘, Kawamura Akane, Schofield Christopher, 菅 裕明

    日本薬学会第143年会  2023.3 

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  • アミノアシルtRNAの化学的N-末端修飾とin vitro翻訳系への応用

    The 103rd CSJ Annual Meeting  2023.3 

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  • RaPIDセレクションを用いた免疫チェックポイントを阻害するペプチドの開発

    The 103rd CSJ Annual Meeting  2023.3 

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  • 分子進化によるタンパク質・RNA 高次複合体の創成 Invited

    寺坂 尚紘

    第１回 発動分子科学サロン 「発動分子と生体材料」  2022.12 

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  • In vitro assembly of protein capsules packaging RNA

    Naohiro Terasaka

    The 45th Annual Meeting of the Molecular Biology Society of Japan  2022.12 

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    Event date： 2022.11 - 2022.12

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  • Aminoacylation ribozymes evolved from a natural riboswitch Invited International conference

    Naohiro Terasaka

    Symposium on Evolution and Emergence of Living Systems: from Geochemistry to Synthetic Biology  2022.10 

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  • In vitro reconstitution of artificial virus-like particles

    Naohiro Terasaka

    Japanese Society For Cell Synthesis Research annual meeting 15.0  2022.10 

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  • Directed evolution of protein assembly Invited

    Naohiro Terasaka

    The 60th Annual Meeting of the Biophysical Society of Japan  2022.9 

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    Event date： 2022.9

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  • 原始ウイルスの進化を実験室内で再現する Invited

    寺坂尚紘

    日本進化学会年大会 第24回沼津大会  2022.8 

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    Event date： 2022.8

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  • Development of aminoacylation ribozyme by tRNA 3’ sensing in vitro selection strategy

    Wei Lu, Naohiro Terasaka, Hiroaki Suga

    23th RNA society Japan annual meeting  2022.7 

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  • Construction of a peptide library containing cyclic γ-amino acids for discovery of SARS-CoV-2 main protease inhibitors International coauthorship

    Takashi Miura, Malla Tika, Owen David, Tumber Anthony, Brewitz Lennart, McDonough Michael, Salah Eidarus, Naohiro Terasaka, Takayuki Katoh, Lukacik Petra, Strain-Damerell Claire, Mikolajek Halina, Walsh Martin, Kawamura Akane, Schofield Christopher, Hiroaki Suga

    BIO UT 2022  2022.6 

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  • Constructing a ribosome library with random mutations in peptidyl transferase center and screening ribosome sequences to incorporate noncanonical amino acids

    Daiki Kanayama, Takayuki Katoh, Naohiro Terasaka, Hiroaki Suga

    The 102nd CSJ Annual Meeting  2022.3 

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  • Development of Macrocyclic Peptide Heterodimer as PPI Inhibitor against Immune Checkpoint CD47- SIRPα

    Jinxuan Zhao, Yoji Murata, Naohiro Terasaka, Takashi Matozaki, Hiroaki Suga

    The 102nd CSJ Annual Meeting  2022.3 

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  • Ribosomal synthesis of N-myristoylated peptide

    Hiroki Murakami, Naohiro Terasaka, Hiroaki Suga

    The 102nd CSJ Annual Meeting  2022.3 

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  • Discovery of a cis-acting ribozyme conducting new type of reaction by in vitro selection

    Wei Lu, Naohiro Terasaka, Hiroaki Suga

    The 102nd CSJ Annual Meeting  2022.3 

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  • Laboratory evolution of a virus-like nucleocapsid from a bacterial enzyme International coauthorship International conference

    Naohiro Terasaka, Hiroaki Suga, Donald Hilvert

    RIKEN BDR Symposium 2022  2022.3 

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  • タンパク質カプセルへの環状ペプチド移植による肝細胞増殖因子受容体アゴニストの創成

    寺坂尚紘, 小松大和, 酒井克也, 三原恵美子, 若林里咲, 松本邦夫, Hilvert Donald, 高木淳一, 菅裕明

    第15回バイオ関連化学シンポジウム  2021.9 

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    Event date： 2021.9

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  • Mutant ribosome?tRNA pair towards orthogonal genetic code International conference

    Terasaka N, Hayashi G, Katoh H, Suga H

    9th International Symposium on Aminoacyl-tRNA Synthetases  2013.10 

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    Event date： 2013.10

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  • Discovery of human small non-coding RNAs binding to small molecules by SELEX-NT International conference

    Terasaka N, Futai K, Katoh T, Suga H

    RiboClub Annual Meeting 2013  2013.9 

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  • 変異リボソーム・tRNAペアを用いた直交性遺伝暗号の創成

    寺坂尚紘, 林剛介, 加藤敬行, 菅裕明

    第15回日本RNA学会年会  2013.7 

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    Event date： 2013.7

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  • Ribozymes that catalyze tRNA aminoacylation Invited International conference

    Terasaka N, Ishida S, Katoh T, Suga H

    Pacifichem 2015  2015.12 

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  • A T-box ribozyme with tRNA amioacylation activity International conference

    Ishida S, Terasaka N, Katoh T, Suga H

    10th International Symposium on Aminoacyl-tRNA Synthetase (aaRS2015)  2015.10 

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  • An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center International conference

    Terasaka N, Hayashi G, Katoh H, Suga H

    The 3rd Japan-Swiss Chemical Biology Symposium  2014.10 

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  • An orthogonal ribosome-tRNAs pair by the engineering of peptidyl transferase center International conference

    Terasaka N, Hayashi G, Katoh T, Suga H

    25th tRNA conference  2014.9 

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  • 天然リボソーム・tRNAペアと直交性を持つ変異リボソーム・tRNAペアの構築

    寺坂尚紘, 林剛介, 加藤敬行, 菅裕明

    日本ケミカルバイオロジー学会第9回年会  2014.6 

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  • In vitroセレクションを用いて小分子結合性small non-coding RNAを探索する

    寺坂尚紘, 二井一樹, 加藤敬行, 菅裕明

    第16回生命化学研究会  2014.1 

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  • The translational activity of a CCA-mutated tRNA-ribosome mutant pair International conference

    Terasaka N, Suga H

    Annual Symposium on Academic English for Chemistry  2013.2 

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  • Translational activity of CCA-mutated tRNA-ribosome mutant pair. International conference

    Terasaka N, Hayashi G, Katoh H, Suga H

    XXIV tRNA conference  2012.12 

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  • 変異リボソーム・tRNAペアによる直交性遺伝暗号の創成

    寺坂尚紘, 林剛介, 加藤敬行, 菅裕明

    RNAフロンティアミーティング2012  2012.9 

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  • In vitroセレクションによる生体内小分子に結合するヒトsmall non-coding RNAの探索

    寺坂尚紘, 二井一樹, 加藤敬行, 後藤佑樹, 菅裕明

    第24回高遠シンポジウム  2012.8 

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  • In vitroセレクションを用いた生体内小分子に結合するヒトsmall non-coding RNAの探索

    寺坂尚紘, 二井一樹, 加藤敬行, 後藤佑樹, 菅裕明

    第14回日本RNA学会年会  2012.7 

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  • 生体内小分子に結合するヒトsmall non-coding RNAの探索

    寺坂尚紘, 二井一樹, 加藤敬行, 菅裕明

    新規素材探索第11回セミナー  2012.6 

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  • in vitro セレクションによる小分子結合性small non-coding RNAの探索

    寺坂尚紘, 加藤敬行, 菅裕明

    第34回日本分子生物学会年会  2011.12 

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  • RaPID システムを利用して環状N-メチルペプチド阻害剤を探索する

    山岸祐介, 寺坂尚紘, 菅裕明

    第13回生命化学研究会シンポジウム（冬季  2011.1 

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  • アーキアtRNAIleに見出された新規RNA修飾塩基アグマチジンの機能と生合成機構の解明

    池内与志穂, 木村 聡, 寺坂尚紘, 沼田倫征, 大澤拓生, 中村大吾, 横川隆志, 緒方俊彦, 和田 猛, 鈴木健夫, 鈴木 勉

    第12回日本RNA学会年会  2010.7 

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  • RNA・タンパク質カプシド複合体の実験室内進化 International coauthorship

    寺坂尚紘, 東佑翼, Tetter Stephan, 菅 裕明, Hilvert Donald

    第41回日本分子生物学会年会  2018.11 

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  • ウイルスを模倣した人工ヌクレオカプシドの実験室内進化 International coauthorship

    寺坂尚紘, 東佑翼, Tetter Stephan, Hilvert Donald

    「細胞を創る」研究会11.0  2018.10 

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  • Engineering and directed evolution of virus-like nucleocapsids International coauthorship International conference

    Terasaka N, Azuma Y, Hilvert D

    2nd ETH Zurich The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing and Innovation,  2018.1 

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  • T-boxリボスイッチに基づいたtRNA認識アミノアシル化リボザイムの開発

    Ishida S, Terasaka N, Katoh T, Suga H

    第5回バイオ関連化学シンポジウム若手フォーラム  2017.9 

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  • In vitro selection法によるtRNA認識とアミノアシル活性を併せ持ったリボザイムの開発

    Ishida S, Terasaka N, Katoh T, Suga H

    第11回バイオ関連化学シンポジウム  2017.9 

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  • In vivo packaging of small RNAs into engineered nonviral protein capsids International coauthorship International conference

    Terasaka N, Edwardson T.G.W, Azuma Y, Hilvert D

    Gordon Research Conference on Physical Virology  2017.1 

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  • Ribozymes with tRNA recognition and aminoacylation properties” 26th tRNA conference International conference

    Ishida S, Terasaka N, Katoh T, Suga H

    26th tRNA conference  2016.9 

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  • Microfluidic cell sorter-aided directed evolution of box C/D snoRNP to site-specifically introduce N6-methyladenosine International coauthorship International conference

    Terasaka N, Hilvert D

    16th HFSP meeting  2016.7 

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  • Microfluidic compartmentalized directed evolution of box C/D snoRNP to methylate RNA bases International coauthorship International conference

    Terasaka N, Hilvert D

    RNA 2016  2016.6 

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  • In vitro selection of tRNA-recognizing aminoacylation ribozyme derived from a T-box motif International conference

    Ishida S, Terasaka N, Katoh T, Suga H

    RNA 2016  2016.6 

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  • An aminoacylation ribozyme evolved from a natural tRNA sensing riboswitch Invited

    2020.12 

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  • RANKL-RANK-OPGシグナル研究の最前線 膜型RANKLを標的にした骨形成促進薬の開発

    青木 和広, 清水 優里, Lu Wei, 廣橋 優奈, 曽根 絵梨, 池淵 祐樹, Masud Khan, Fatma Rashed, 田村 幸彦, 菅森 泰隆, 寺坂 尚紘, 宇田川 信之, 依田 哲也, 本間 雅, 菅 裕明

    第62回歯科基礎医学会学術大会 アップデートシンポジウム  2020.10 

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  • 天然リボスイッチ配列から進化させ、翻訳系中で働くアミノア シル tRNA合成リボザイム

    寺坂 尚紘, 石田啓, 加藤敬行, 菅裕明

    第42回日本分子生物学会年会  2019.12 

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  • T-box リボスイッチをベースにした tRNA 認識アミノアシル化リボザイムの創出

    石田啓, 寺坂 尚紘, 加藤敬行, 菅裕明

    第21回日本RNA学会年会  2019.7 

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  • Directed evolution of non-viral protein cages to package their own mRNA International coauthorship

    Terasaka Naohiro, Azuma Yusuke, Tetter Stephan, Hiroaki Suga, Hilvert Donald

    JSCB-PSSJ2019  2019.6 

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  • An aminoacylation ribozyme evolved from a natural tRNA sensing riboswitch International conference

    Terasaka Naohiro, Ishida Satoshi, Katoh Takayuki, Suga Hiroaki

    The 24th Annual Meeting of the RNA Society  2019.6 

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  • Application of BLI for discovery of natural RNA aptamers Invited

    Terasaka Naohiro

    2019.5 

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  • Reconstruction of virus origin in a laboratory Invited

    Terasaka Naohiro

    Keio Astrobiology Camp 2019  2019.3 

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  • Directed evolution of bacterial protein cages to package their own mRNA Invited

    Terasaka Naohiro

    New Frontier in Protein Design & Engineering  2019.3 

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  • De novo macrocyclic peptide inhibitors containing cyclic γ-amino acids targeting the SARS-CoV-2 main protease International coauthorship International conference

    Takashi Miura, Malla Tika, Owen Davi, Tumber Anthony, Brewitz Lennar, McDonough Michael, Salah Eidarus, Naohiro Terasaka, Takayuki Katoh, Lukacik Petr, Strain-Damerell Claire, Mikolajek Halin, Walsh Marti, Kawamura Akane, Schofield Christopher, Hiroaki Suga

    Boulder Peptide Symposium 2022  2022.11 

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  • Ribosomal synthesis of a peptide library containing cyclic γ-amino acids for discovery of SARS-CoV-2 main protease inhibitors International coauthorship

    Takashi Miura, Malla Tika, Owen Davi, Tumber Anthony, Brewitz Lennar, McDonough Michael, Salah Eidarus, Naohiro Terasaka, Takayuki Katoh, Lukacik Petr, Strain-Damerell Claire, Mikolajek Halin, Walsh Marti, Kawamura Akane, Schofield Christopher, Hiroaki Suga

    The 59th Japanese Peptide Symposium  2022.10 

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  • Screening de novo RNA-binding peptides using codon-depleted mRNA display International conference

    Kosuke Fujishima, Shota Nishikawa, Hidenori Watanabe, Naohiro Terasaka, Takayuki Katoh

    2022 Astrobiology Science Conference  2022.5 

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  • In vitro evolution of aminoacylation ribozymes and their applications International conference

    Naohiro Terasaka, Satoshi Ishida, Takayuki Katoh, Kazuki Futai, Wei Lu, Hiroaki Suga

    2021.12 

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  • 無細胞翻訳系を用いたタンパク質N末端への非天然アミノ酸導入法

    古川晴之, 寺坂尚紘

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    Application no：特願2026-082806 

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  • 液滴分取装置及び液滴分取方法

    磯崎瑛宏, 那須雄介, 寺坂尚紘

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    Application no：特願2025-002732 

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  • ＲＮＡポリメラーゼ改変体

    寺坂尚紘

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    Application no：特願2025-140438 

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Awards

  • Young Scientist Award

    2019.6   Protein Science Society Japan  

    Terasaka Naohiro

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  • 東京大学大学院理学系研究科研究奨励賞受賞

    2015.3  

    寺坂 尚紘

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  • 25th tRNA conference, Sidney Altman Endowment Travel Award 受賞

    2014.9  

    寺坂 尚紘

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  • 第15回日本RNA学会年会優秀賞受賞

    2013.7  

    寺坂 尚紘

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  • 第63回リンダウ・ノーベル賞受賞者会議に日本学術振興会より派遣

    2013.6  

    寺坂 尚紘

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Research Projects

  • マイクロ流路デバイスを用いたセルフリータンパク質進化

    2026.4 - 2028.3

    公益財団法人豊田理化学研究所  豊田理研スカラー共同研究 (Phase2) 

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  • ボトムアップ合成ウイルス学

    2025.4 - 2028.3

    科学技術振興機構  創発的研究支援事業 

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  • 天然を超えた効率的物質生産を可能にする人工特化メタボロンの創成

    Grant number：25H01420  2025.4 - 2028.3

    日本学術振興会  科学研究費助成事業  学術変革領域研究(B)

    寺坂 尚紘

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    Grant amount：\35750000 （ Direct Cost: \27500000 、 Indirect Cost：\8250000 ）

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  • 多様なモダリティの薬剤分子を迅速創出する無細胞プラットフォームの構築

    Grant number：25K01913  2025.4 - 2028.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    寺坂 尚紘

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    Grant amount：\18720000 （ Direct Cost: \14400000 、 Indirect Cost：\4320000 ）

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  • マイクロ流路デバイスを用いたセルフリータンパク質進化

    2025.4 - 2026.3

    公益財団法人豊田理化学研究所  豊田理研スカラー共同研究 (Phase1) 

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  • 機能性核酸ペプチド複合体進化システムの構築と原始翻訳系の解明

    2024.7 - 2029.3

    武田科学振興財団  生命科学研究助成 

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  • 多様な薬剤の迅速探索を可能にする無細胞連続進化システムの構築

    2024.4 - 2027.3

    公益財団法人内藤記念科学振興財団  2023年度内藤記念次世代育成支援研究助成金 

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  • 核酸タンパク質複合体を用いた細胞内ナノ構造体構築

    2024.4 - 2027.3

    独立行政法人日本学術振興会  挑戦的研究（萌芽） 

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    Authorship：Principal investigator 

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  • 高純度mRNA薬剤の合成を可能にするRNAポリメラーゼの開発

    2024.4 - 2025.3

    中外創薬科学財団  特別研究助成金 SRG2022 

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  • 受容体クラスター化アゴニストの指向性進化

    2024.1 - 2025.12

    公益財団法人アステラス病態代謝研究会 研究助成 

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  • 抗菌ペプチドの微量迅速探索法の開発

    2024.1 - 2024.12

    公益財団法人 持田記念医学薬学振興財団  2023年度研究助成 

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  • 抗菌ペプチド無細胞スクリーニング系の開発

    2024.1 - 2024.12

    シオノギ感染症研究振興財団  次世代育成支援研究助成金 

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  • Development of RNA-guided programmed cell death technology using CRISPR-Cas7-11

    2023.7 - 2024.3

    Kazuki Kato, Naohiro Terasaka

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    Authorship：Coinvestigator(s) 

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  • 多量体化人工抗体によるMETを標的とした人工成長因子の創成

    2022.4 - 2023.3

    金沢大学がん進展制御研究所 共同研究 

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  • 相分離進化工学による人工オルガネラの創成

    2021.10 - 2025.3

    科学技術振興機構  戦略的創造研究推進事業（さきがけ） 

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  • 非天然アミノ酸を含む高次機能性タンパク質集合体の極微量分子進化

    2021.10 - 2024.3

    独立行政法人日本学術振興会  学術変革領域研究B 

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  • METをターゲットとする小分子薬剤・タンパク質複合体の構築

    2020.4 - 2021.3

    金沢大学がん進展制御研究所  共同研究 

    寺坂尚紘, 松本邦夫

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    Authorship：Principal investigator 

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  • 標的特異的ドラッグデリバリーを可能にするタンパク質カプセルの分子進化

    2020.4 - 2021.3

    公益財団法人 野口研究所  野口遵研究助成金 

    寺坂尚紘

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    Authorship：Principal investigator 

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  • 分子進化によるウイルス細胞脱出起源仮説の再現

    2020.4 - 2021.3

    自然科学研究機構アストロバイオロジーセンター  プロジェクト研究 

    寺坂尚紘

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    Authorship：Principal investigator 

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  • 多様な非天然アミノ酸を許容するリボソームの人工進化

    2020.1 - 2020.12

    一般財団法人材料科学技術振興財団  研究助成 

    寺坂尚紘

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  • tRNAのアミノアシル化を触媒するペプチド・リボザイム複合体の分子進化

    2019.4 - 2022.3

    独立行政法人日本学術振興会  若手研究 

    寺坂 尚紘

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    Authorship：Principal investigator  Grant type：Competitive

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  • 分子進化工学によるウイルス出芽機構の解明

    2019.4 - 2020.3

    公益財団法人豊田理化学研究所  豊田理研スカラー 

    寺坂 尚紘

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    Authorship：Principal investigator  Grant type：Competitive

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  • HGF-MET系をターゲットとしたドラッグデリバリーシステムの開発

    2019.4 - 2020.3

    金沢大学がん進展制御研究所  金沢大学がん進展制御研究所共同研究 

    寺坂 尚紘

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    Authorship：Principal investigator  Grant type：Competitive

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  • 抗HGF特殊環状ペプチドのイメージング活用創薬

    2016.4 - 2021.3

    国立研究開発法人 日本医療研究開発機構  次世代がん医療創生研究事業（P-CREATE） 

    寺坂尚紘

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    Authorship：Coinvestigator(s) 

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  • Site-specific introduction of N6-methyladenosine using engineered snoRNP by directed evolution

    2015.4 - 2018.3

    ヒューマン・フロンティア・サイエンス・プログラム（HFSP): 長期フェロー 

    寺坂 尚紘

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    Authorship：Principal investigator  Grant type：Competitive

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  • 生体内小分子によって成熟が制御されるヒトmiRNA前駆体の探索及び機能解析

    2012.4 - 2014.3

    独立行政法人日本学術振興会: 特別研究員（DC1） 

    寺坂 尚紘

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    Authorship：Principal investigator  Grant type：Competitive

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Other

  • 日本学術振興会海外特別研究員 採用内定（辞退）

    2015.4

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  • 日本学生支援機構大学院第一種奨学生 特に優れた業績による返還免除

    2012.3

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Teaching Experience

  • Synnthetic Biology

    2023.6 - 2025.6 Institution：Tokyo Institute of Technology

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  • Earth-Life Science A

    2023.4 Institution：Tokyo Institute of Technology

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  • 有機化学実験

    2019.10 Institution：東京大学理学部化学科

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  • 有機化学演習

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  • Biological Chemistry I: Nucleic Acids & Carbohydrates

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Social Activities

  • 横浜サイエンスフロンティア高校生への講演

    Role(s)： Lecturer

    2025.9

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    Type：Lecture

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  • 都立墨田川高校 大学模擬授業

    Role(s)： Lecturer

    2024.10

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    Type：Visiting lecture

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  • 東京工業大学 地球生命研究所 一般講演会 2024

    Role(s)： Presenter

    2024.2

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  • 都立竹早高校生への講演

    Role(s)： Lecturer

    2023.7

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Academic Activities

  • 機能性生体分子の合理デザイン（第98回日本生化学会大会）

    Role(s)： Panel moderator, session chair, etc.

    2025.11

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  • 異分野融合が切り拓くタンパク質工学フロンティア（第24回日本蛋白質科学会年会ワークショップ）

    Role(s)： Panel moderator, session chair, etc.

    2024.6

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  • 日本生物物理学会 分野別専門委員

    2024.1

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  • ELSI seminar

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    Naohiro Terasaka  2023.7

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    Type：Academic society, research group, etc. 

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  • ACCELERATING PROTEIN DESIGN AND ENGINEERING (Symposium in the 23rd Annual Meeting of the Protein Science Society of Japan)

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    Yuta Suzuki, Naohiro Terasaka  2023.7

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    Type：Competition, symposium, etc. 

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  • SPEED×Bottom-up×ELSI joint workshop

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    Naohiro Terasaka  2023.7

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    Type：Academic society, research group, etc. 

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  • NISTEP分野別専門委員

    2020.4

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