Updated on 2025/12/17

写真a

 
SUZUKI TAKAHISA
 
Organization
School of Life Science and Technology Specially Appointed Junior Associate Professor
Title
Specially Appointed Junior Associate Professor
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Degree

  • 博士(医学) ( 2016.3   福島県立医科大学 )

  • 修士(医科学) ( 2012.3   福島県立医科大学 )

Research Interests

  • オプトジェネティクス

  • Fluorescent protein

  • 光遺伝学

  • 蛍光顕微鏡

  • シアノバクテリオクロム

  • Live cell imaging

  • バイオイメージング

Research Areas

  • Life Science / Molecular biology

  • Life Science / Biophysics

  • Life Science / Cell biology

Education

  • Fukushima Medical University   School of Medicine

    2012.4 - 2016.3

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  • Fukushima Medical University   School of Medicine

    2010.4 - 2012.3

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  • Yamagata University   Faculty of Engineering   Department of Bio-system Engineering

    2006.4 - 2010.3

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Research History

  • Tokyo Institute of Technology   School of Life Science and Technology   Specially Appointed Junior Associate Professor

    2024.4

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  • Tokyo Metropolitan University

    2023.4 - 2024.3

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  • Tokyo Metropolitan University   Specially Appointed Junior Associate Professor

    2021.4 - 2023.3

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  • Kobe University   Graduate School of Science, Technology and Innovation

    2017.9 - 2021.3

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  • 国立がん研究センター 東病院   機能診断開発分野   特任研究員

    2016.11 - 2017.8

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  • CORNES Technologies Ltd.   Science Equipment Department   Field Application Engineer

    2016.4 - 2016.10

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Professional Memberships

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Papers

  • Crucial residue for tuning thermal relaxation kinetics in the biliverdin-binding cyanobacteriochrome photoreceptor revealed by site-saturation mutagenesis Reviewed

    Takahisa Suzuki, Masataka Yoshimura, Munehito Arai, Rei Narikawa

    Journal of Molecular Biology   168451 - 168451   2024.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jmb.2024.168451

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  • Introduction of reversible cysteine ligation ability to the biliverdin‐binding cyanobacteriochrome photoreceptor Reviewed

    Takahisa Suzuki, Masataka Yoshimura, Hiroki Hoshino, Keiji Fushimi, Munehito Arai, Rei Narikawa

    The FEBS Journal   2023.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/febs.16911

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  • Development of Cysteine-Free Fluorescent Proteins for the Oxidative Environment Reviewed

    Takahisa Suzuki, Seisuke Arai, Mayumi Takeuchi, Chiye Sakurai, Hideaki Ebana, Tsunehito Higashi, Hitoshi Hashimoto, Kiyotaka Hatsuzawa, Ikuo Wada

    PLoS ONE   7 ( 5 )   e37551 - e37551   2012.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0037551

    Web of Science

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  • Conformational change in an engineered biliverdin-binding cyanobacteriochrome during the photoconversion process Reviewed

    Yuka Takeda, Itsuki Ohtsu, Takahisa Suzuki, Yusuke Nakasone, Keiji Fushimi, Masahiko Ikeuchi, Masahide Terazima, Hideo Dohra, Rei Narikawa

    Archives of Biochemistry and Biophysics   109715 - 109715   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.abb.2023.109715

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  • Cytosine base editing systems with minimized off-target effect and molecular size Reviewed

    Ang Li, Hitoshi Mitsunobu, Shin Yoshioka, Takahisa Suzuki, Akihiko Kondo, Keiji Nishida

    Nature Communications   13 ( 1 )   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    Abstract

    Cytosine base editing enables the installation of specific point mutations without double-strand breaks in DNA and is advantageous for various applications such as gene therapy, but further reduction of off-target risk and development of efficient delivery methods are desired. Here we show structure-based rational engineering of the cytosine base editing system Target-AID to minimize its off-target effect and molecular size. By intensive and careful truncation, DNA-binding domain of its deaminase PmCDA1 is eliminated and additional mutations are introduced to restore enzyme function. The resulting tCDA1EQ is effective in N-terminal fusion (AID-2S) or inlaid architecture (AID-3S) with Cas9, showing minimized RNA-mediated editing and gRNA-dependent/independent DNA off-targets, as assessed in human cells. Combining with the smaller Cas9 ortholog system (SaCas9), a cytosine base editing system is created that is within the size limit of AAV vector.

    DOI: 10.1038/s41467-022-32157-8

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    Other Link: https://www.nature.com/articles/s41467-022-32157-8

  • Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice Reviewed

    Naokazu Inoue, Yoshihisa Hagihara, Danelle Wright, Takahisa Suzuki, Ikuo Wada

    Nature Communications   6 ( 1 )   8858   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms9858

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Books

  • Phytochromes Methods and Protocols

    Takahisa Suzuki, Ayano Yoneda, Tomo Yokota, Hiroki Hoshino, Keita Miyake, Keiji Fushimi, Rei Narikawa( Role: ContributorDiscovery and Engineering of Unique Cyanobacteriochrome GAF Domains)

    Methods in Molecular Biology  2025.10 

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Presentations

  • Development of the cyanobacteriochrome photoreceptor with unique wavelength characteristics by site saturation mutagenesis

    2022.12 

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    Presentation type:Poster presentation  

    File: Grafical abstract_2022MBSJ_szk.jpg

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  • 部位特異的飽和変異導入によってもたらされたビリベルジン結合型光受容体タンパク質の多様性

    鈴木貴久, 吉村匡隆, 星野宏季, 伏見圭司, 新井宗仁, 成川礼

    第46回分子生物学会年会  2023.12 

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    Language:Japanese   Presentation type:Poster presentation  

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  • Cyanobacteriochromes: Introduction of unique photoreceptors and prospects for application

    Takahisa Suzuki

    2022.9 

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    Language:English  

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  • Live-cell imaging of antitrypsin Z-variant polymer inclusion

    Seisuke Arai, Takahisa Suzuki, Ikuo Wada

    2018.6 

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    Language:English   Presentation type:Poster presentation  

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  • Role of IGF2BP1 on aberrant migration of a malignant meningioma, HKBMM cells

    2018.10 

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  • 分泌系タンパク質イメージングのための蛍光タグの検討

    鈴木貴久, 和田郁夫

    第38回日本分子生物学会年会・第88回日本生化学会大会合同大会  2015.12 

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    Language:English   Presentation type:Poster presentation  

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  • 融合因子IZUMO1の構造変化による新規膜融合モデル

    井上直和, 萩原義久, Danelle Wright, 鈴木貴久, 和田郁夫

    第38回日本分子生物学会年会 (ワークショップ)  2015.12 

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    Presentation type:Oral presentation (general)  

    Venue:神戸市  

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  • Photoconversion-induced FRETの検討

    鈴木貴久, 橋本仁志, 竹内真由美, 和田郁夫

    第37会日本分子生物学学会年会  2014.11 

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    Language:English   Presentation type:Poster presentation  

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  • Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1

    2015.9 

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    Presentation type:Oral presentation (general)  

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  • Live-cell molecular imaging in the oxidative environment using cysteine-free fluorescent proteins International conference

    Takahisa Suzuki, Ikuo Wada

    The American Society for Cell Biology The 2012 Anual Meeting 

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    Language:English  

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  • 酸化的環境で機能する光変換蛍光タンパクの開発と細胞機能制御計測

    鈴木貴久, 橋本仁志, 和田郁夫

    第86回日本生化学大会  2013.9 

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    Presentation type:Oral presentation (general)  

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Awards

  • 第86回日本生化学会大会 鈴木紘一メモリアル賞

    2013.9  

    鈴木 貴久

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Research Projects

  • 細胞外環境での小さな操作分子イメージングツールの開発

    2013.4 - 2016.3

    日本学術振興会  特別研究員(DC1) 

    鈴木 貴久

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    Authorship:Principal investigator  Grant type:Competitive

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Academic Activities

  • イメージング若手の会 第15回「光塾」 塾長

    Role(s): Planning, management, etc., Panel moderator, session chair, etc.

    2024.1

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    Type:Academic society, research group, etc. 

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