Organization
Institute of Integrated Research Cell Biology Center Specially Appointed Professor
Title
Specially Appointed Professor
External link
YOSHINORI OHSUMI
Research Interests
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Autophagy
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Molecular Cell Biology
Research Areas
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Life Science / Cell biology
Education
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The University of Tokyo Graduate School, Division of Science
1967 - 1972
Country： Japan
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The University of Tokyo College of Arts and Sciences Department of Basic Science
1963.4 - 1967.3
Research History
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Tokyo Institute of Technology Institute of Innovative Research Adjunct Professor
2016.4
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Tokyo Institute of Technology Frontier Research Center Adjunct Professor
2010.4
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Tokyo Institute of Technology Advanced Research Organization, Integrated Research Institute Adjunct Professor
2009.4 - 2010.3
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National Institute of Natural Sciences Department of Cell Biology, National Institute of Basic Biology Professor
2004.4 - 2009.3
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Okazaki Natioanl Research Institutes Department of Cell Biology, National Institute for Basic Biology Professor
1996.4 - 2004.3
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The University of Tokyo Department of Biology, College of Arts and Sciences Associate Professor
1988.4 - 1996.3
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The University of Tokyo Department of Biology, Faculty of Science Lecturer
1986.7 - 1988.3
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The University of Tokyo Department of Biology, Faculty of Science Research Associate
1977.12 - 1986.6
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Rockefeller University Postdoctoral Fellow
1974 - 1977
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The University of Tokyo Department of Agricultural Chemistry, Faculty of Agriculture Research Fellow
1972 - 1974
Professional Memberships
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Advancing Science Serving Society
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Genetic Society of America
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The American Society for Cell Biology
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American Society for Biochemistry and Molecular Biology
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The Japanese Society of Plant Physiologists
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The Botanical Society of Japan
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The Japanese Biochemical Society
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The Molecular Biology Society of Japan
MISC
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Mouse Apg16L. a novel WD-repeat protein, targets to the autophagy isolation membrane with the Apg12-Apg5 conjugate.
Journal of Cell Science 116, 1679-1688 2003
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The early secretory pathway contributes to autophagy in yeast.
Cell Structure and Function. 28, 49-54 2003
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The early secretory pathway contributes to autophagy in yeast.
Cell Structure and Function. 28, 49-54 2003
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Mouse Apg16L. a novel WD-repeat protein, targets to the autophagy isolation membrane with the Apg12-Apg5 conjugate.
Journal of Cell Science 116, 1679-1688 2003
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Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene
H Hanaoka, T Noda, Y Shirano, T Kato, H Hayashi, D Shibata, S Tabata, Y Ohsumi
PLANT PHYSIOLOGY 129 ( 3 ) 1181 - 1193 2002.7
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Formation of the similar to 350-kDa Apg12-Apg5 center dot Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
A Kuma, N Mizushima, N Ishihara, Y Ohsumi
JOURNAL OF BIOLOGICAL CHEMISTRY 277 ( 21 ) 18619 - 18625 2002.5
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Analysis by the conjugation-mediated yeast two hybrid method
FEBS Letters 532, 450-454 2002
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The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquin myopathy.
The Journal of Biochemistry 131, 647-651 2002
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SKD1, AAA-ATPase-dependent endosomal transport is involved in autolysosome formation.
Cell Structure and Function 27, 29-37 2002
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Analysis by the conjugation-mediated yeast two hybrid method
FEBS Letters 532, 450-454 2002
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Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae.
Developmental Cell 3, 815-824 2002
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SKD1, AAA-ATPase-dependent endosomal transport is involved in autolysosome formation.
Cell Structure and Function 27, 29-37 2002
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Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae.
Developmental Cell 3, 815-824 2002
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The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquin myopathy.
The Journal of Biochemistry 131, 647-651 2002
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Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure
Takahiro Shintani, Kuninori Suzuki, Yoshiaki Kamada, Takeshi Noda, Yoshinori Ohsumi
Journal of Biological Chemistry 276 ( 32 ) 30452 - 30460 2001.8
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The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1-activity and E1-E2 complex-formation.
The Journal of Biological Chemistry 276, 9846-9854 2001
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Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.
The Journal of Cell Biology 152, 657-668 2001
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Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for its fusion to the vacuole.
Molecular Biology of the Cell 12. 3690-3702 2001
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Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole.
The Journal of Cell Biology 153, 381-396 2001
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The preautophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.
EMBO Journal 20, 5971-5981 2001
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Apg2p functions in autophagosome formation on the perivacuolar structure.
The Journal of Biological Chemistry 276, 30452-30460 2001
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Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole.
The Journal of Cell Biology 153, 381-396 2001
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The preautophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.
EMBO Journal 20, 5971-5981 2001
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Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for its fusion to the vacuole.
Molecular Biology of the Cell 12. 3690-3702 2001
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Beclin-phsophatidylinositol 3-kinase complex functions at the trans-Golgi network
EMBO Report 2, 330-335 2001
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Two distinct Vps34 PtdIns 3-kinase complexes function in autophagy and CPY sorting in Saccharomyces cerevisiae
The Journal of Cell Biology 152, 519-530 2001
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Beclin-phsophatidylinositol 3-kinase complex functions at the trans-Golgi network
EMBO Report 2, 330-335 2001
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Two distinct Vps34 PtdIns 3-kinase complexes function in autophagy and CPY sorting in Saccharomyces cerevisiae
The Journal of Cell Biology 152, 519-530 2001
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The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1-activity and E1-E2 complex-formation.
The Journal of Biological Chemistry 276, 9846-9854 2001
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Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.
The Journal of Cell Biology 152, 657-668 2001
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Apg5p functions in the sequestration step in the cytoplasm to vacuole targeting and macroautophagy pathways.
Molecular Biology of the Cell, 11, 969-982 2000
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A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes.
The Journal of Biological Chemistry The Journal of Biological Chem 2000
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Apg9/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways.
The Journal of Cell Biology 148, 465-479 2000
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Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
The Journal of Cell Biology 150, 1507-1513 2000
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Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting.
The Journal of Biological Chemistry 275, 25840-25849 2000
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LC3, a mammalian homologue of yeast Apg8p is processed and localized in autophagosome membranes.
EMBO Journal 19, 5720-5728 2000
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The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
The Journal of Cell Biology 151, 263-275 2000
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A Ubiquitin-like system mediates protein lipidation.
Nature 408, 488-492 2000
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Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion.
The Journal of Cell Biology 151, 453-466 2000
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Apg5p functions in the sequestration step in the cytoplasm to vacuole targeting and macroautophagy pathways.
Molecular Biology of the Cell, 11, 969-982 2000
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SKD1, an AAA ATPase related to the yeast Vps4p, regulates morphology and transport function of early endosomes.
Molecular Biology of the Cell 11, 747-763 2000
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Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting.
The Journal of Biological Chemistry 275, 25840-25849 2000
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A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes.
The Journal of Biological Chemistry The Journal of Biological Chem 2000
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The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
The Journal of Cell Biology 151, 263-275 2000
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Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
The Journal of Cell Biology 150, 1507-1513 2000
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Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion.
The Journal of Cell Biology 151, 453-466 2000
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LC3, a mammalian homologue of yeast Apg8p is processed and localized in autophagosome membranes.
EMBO Journal 19, 5720-5728 2000
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A Ubiquitin-like system mediates protein lipidation.
Nature 408, 488-492 2000
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SKD1, an AAA ATPase related to the yeast Vps4p, regulates morphology and transport function of early endosomes.
Molecular Biology of the Cell 11, 747-763 2000
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Apg9/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways.
The Journal of Cell Biology 148, 465-479 2000
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Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
Noboru Mizushima, Takeshi Noda, Yoshinori Ohsumi
EMBO Journal 18 ( 14 ) 3888 - 3896 1999.7
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Apg7p/Cvt2p: a novel protein activating enzyme essential for autophagy.
Molecular and Cellular Biology 10, 1367-1379 1999
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Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast.
EMBO Journal, 18, 5234-5241 1999
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Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagic pathway.
EMBO Journal 18, 3888-3896 1999
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Vacuolar import of proteins and organelles from the cytoplasm.
Annual Review of Cell Developmental Biology 15, 1-32 1999
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Formation process of autophagosome is traced with Apg8/Aut7p in yeast.
The Journal of Cell Biology The Journal of Cell Biology 1999
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Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast.
EMBO Journal, 18, 5234-5241 1999
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Apg7p/Cvt2p: a novel protein activating enzyme essential for autophagy.
Molecular and Cellular Biology 10, 1367-1379 1999
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Vacuolar import of proteins and organelles from the cytoplasm.
Annual Review of Cell Developmental Biology 15, 1-32 1999
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Formation process of autophagosome is traced with Apg8/Aut7p in yeast.
The Journal of Cell Biology The Journal of Cell Biology 1999
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A protein conjugation system essential for autophagy.
Nature 395, 395-3983 1998
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A protein conjugation system essential for autophagy.
Nature 395, 395-3983 1998
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Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
The Journal of Biological Chemistry 273, 22284-22291 1998
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Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
The Journal of Biological Chemistry 273, 22284-22291 1998
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A new protein conjugation system in human : The counterpart of the yeast Apg12p conjugation system essential for autophagy.
The Journal of Biological Chemistry 273, 33889-33892 1998
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A new protein conjugation system in human : The counterpart of the yeast Apg12p conjugation system essential for autophagy.
The Journal of Biological Chemistry 273, 33889-33892 1998
Awards
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Nobel Prize in Physiology or Medicine
2016.10 The Nobel Assembly at Karolinska Institutet Sweden
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Dr. Paul Janssen Award for Biomedical Research
2016.6 Johnson & Johnson USA
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Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research
2016.4 Brandeis University USA
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Wiley Prize
2016.4 The Wiley Foundation USA
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International Prize for biology
2015.12 Japan Society for the Promotion of Science Japan
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The Keio Medical Science Prize
2015.11 Keio University Medical Science Fund Japan
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The Person of Cultural Merit
2015.11 Ministry of Education, Culture, Sports, Science and Technology Japan
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Canada Gairdner International Award
2015.10 The Gairdner Foundation Canada
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Thomson Reuters Citation Laureates
2013.9 Thomson Reuters
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Kyoto Prize
2012.11 Inamori Foundation Japan
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The Asahi Award
2008.1 The Asahi Shimbun Foundation Japan
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Academic Prize
2007.7 The Botanical Society of Japan Japan
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The Japan Academy Prize
2006.7 The Japan Academy Japan
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Fujiwara Award
2005.6 The Fujiwara Foundation of Science Japan
Research Projects
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オートファジー分子機構の多様性の解明
2007 - 2012
基礎科学研究
Grant type：Competitive
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Grant type：Competitive