Updated on 2026/08/14

写真a

 
OSATO NAOKI
 
Organization
School of Life Science and Technology Specially Appointed Associate Professor
Title
Specially Appointed Associate Professor
External link

Degree

  • Ph.D. ( 2007.3   University of Tsukuba )

Research Interests

  • Enhancer

  • Deep learning

  • Biochemistry

  • Molecular biology

  • Informatics

  • Statistics

  • Genome science

  • Non-coding DNA

  • Insulator

  • Bioinformatics

  • Chromatin interaction

  • Sense-antisense mRNA

  • Non-protein-coding RNA

  • Epigenome

  • Transcription factor

  • Gene expression

  • Regulation of gene expression

  • Computational biology

  • Transcriptional regulation

Research Areas

  • Life Science / System genome science

  • Informatics / Life, health and medical informatics

Professional Memberships

  • 人工知能学会

    2026.4

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  • (資格)JDLA Deep Learning for Engineer 2023#1

    2023.3

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  • (資格)バイオインフォマティクス技術者認定試験

    2022.12

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  • (資格)JDLA Deep Learning for General 2022#3

    2022.11

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  • JAPANESE SOCIETY FOR BIOINFORMATICS

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  • 日本RNA学会

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  • International Society of Computational Biology

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  • INFORMATION PROCESSING SOCIETY OF JAPAN

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  • THE GENETICS SOCIETY OF JAPAN

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  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Papers

  • Cell type–specific functions of nucleic acid-binding proteins revealed by deep learning on co-expression networks

    Naoki Osato, Kengo Sato

    bioRxiv preprint   2024

  • Systematic discovery of regulatory motifs associated with human insulator sites.

    Naoki Osato, Michiaki Hamada

    bioRxiv preprint   2024

  • Bioinformatics Approaches for Determining the Functional Impact of Repetitive Elements on Non-coding RNAs. International journal

    Chao Zeng, Atsushi Takeda, Kotaro Sekine, Naoki Osato, Tsukasa Fukunaga, Michiaki Hamada

    Methods in molecular biology (Clifton, N.J.)   2509   315 - 340   2022

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    With a large number of annotated non-coding RNAs (ncRNAs), repetitive sequences are found to constitute functional components (termed as repetitive elements) in ncRNAs that perform specific biological functions. Bioinformatics analysis is a powerful tool for improving our understanding of the role of repetitive elements in ncRNAs. This chapter summarizes recent findings that reveal the role of repetitive elements in ncRNAs. Furthermore, relevant bioinformatics approaches are systematically reviewed, which promises to provide valuable resources for studying the functional impact of repetitive elements on ncRNAs.

    DOI: 10.1007/978-1-0716-2380-0_19

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  • Discovery of directional chromatin-associated regulatory motifs affecting human gene transcription

    Naoki Osato

    bioRxiv preprint   2020.10

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    Publisher:Cold Spring Harbor Laboratory  

    <title>Abstract</title><sec><title>Background</title>Chromatin interactions are essential in enhancer-promoter interactions (EPIs) and transcriptional regulation. CTCF and cohesin proteins located at chromatin interaction anchors and other DNA-binding proteins such as YY1, ZNF143, and SMARCA4 are involved in chromatin interactions. However, there is still no good overall understanding of proteins associated with chromatin interactions and insulator functions.

    </sec><sec><title>Results</title>Here, I describe a systematic and comprehensive approach for discovering DNA-binding motifs of transcription factors (TFs) that affect EPIs and gene expression. This analysis identified 96 biased orientations [64 forward-reverse (FR) and 52 reverse-forward (RF)] of motifs that significantly affected the expression level of putative transcriptional target genes in monocytes, T cells, HMEC, and NPC and included CTCF, cohesin (RAD21 and SMC3), YY1, and ZNF143; some TFs have more than one motif in databases; thus, the total number is smaller than the sum of FRs and RFs. KLF4, ERG, RFX, RFX2, HIF1, SP1, STAT3, and AP1 were associated with chromatin interactions. Many other TFs were also known to have chromatin-associated functions. The predicted biased orientations of motifs were compared with chromatin interaction data. Correlations in expression level of nearby genes separated by the motif sites were then examined among 53 tissues.

    </sec><sec><title>Conclusion</title>One hundred FR and RF orientations associated with chromatin interactions and functions were discovered. Most TFs showed weak directional biases at chromatin interaction anchors and were difficult to identify using enrichment analysis of motifs. These findings contribute to the understanding of chromatin-associated motifs involved in transcriptional regulation, chromatin interactions/regulation, and histone modifications.

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    DOI: 10.1101/290825

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  • Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes. Reviewed International journal

    Mari Iwase, Soshi Tokiwa, Shigeto Seno, Takako Mukai, Yu-Sheng Yeh, Haruya Takahashi, Wataru Nomura, Huei-Fen Jheng, Sigenobu Matsumura, Tatsuya Kusudo, Naoki Osato, Hideo Matsuda, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto

    The Journal of biological chemistry   295 ( 20 )   7033 - 7045   2020.5

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    Browning of adipose tissue is induced by specific stimuli such as cold exposure and consists of up-regulation of thermogenesis in white adipose tissue. Recently, it has emerged as an attractive target for managing obesity in humans. Here, we performed a comprehensive analysis to identify genes associated with browning in murine adipose tissue. We focused on glycerol kinase (GYK) because its mRNA expression pattern is highly correlated with that of uncoupling protein 1 (UCP1), which regulates the thermogenic capacity of adipocytes. Cold exposure-induced Ucp1 up-regulation in inguinal white adipose tissue (iWAT) was partially abolished by Gyk knockdown (KD) in vivo Consistently, the Gyk KD inhibited Ucp1 expression induced by treatment with the β-adrenergic receptors (βAR) agonist isoproterenol (Iso) in vitro and resulted in impaired uncoupled respiration. Gyk KD also suppressed Iso- and adenylate cyclase activator-induced transcriptional activation and phosphorylation of the cAMP response element-binding protein (CREB). However, we did not observe these effects with a cAMP analog. Therefore Gyk KD related to Iso-induced cAMP products. In Iso-treated Gyk KD adipocytes, stearoyl-CoA desaturase 1 (SCD1) was up-regulated, and monounsaturated fatty acids such as palmitoleic acid (POA) accumulated. Moreover, a SCD1 inhibitor treatment recovered the Gyk KD-induced Ucp1 down-regulation and POA treatment down-regulated Iso-activated Ucp1 Our findings suggest that Gyk stimulates Ucp1 expression via a mechanism that partially depends on the βAR-cAMP-CREB pathway and Gyk-mediated regulation of fatty acid metabolism.

    DOI: 10.1074/jbc.RA119.011658

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  • Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes. Reviewed International journal

    Mari Iwase, Shoko Sakai, Shigeto Seno, Yu-Sheng Yeh, Tony Kuo, Haruya Takahashi, Wataru Nomura, Huei-Fen Jheng, Paul Horton, Naoki Osato, Hideo Matsuda, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto

    Bioscience, biotechnology, and biochemistry   84 ( 2 )   305 - 313   2020.2

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    Specific conditions, such as exposure to cold, can induce the production of brown-like adipocytes in white adipose tissue. These adipocytes express high levels of uncoupling protein 1 (UCP1) and energy expended by generating heat. Thus, these are a potential target for the prevention or treatment of obesity. The present study involved a comprehensive analysis of the adipose tissue to understand the relationship between long non-coding RNA (lncRNA) 2310069B03Rik and UCP1. Cold exposure increased both lncRNA 2310069B03Rik and Ucp1 expression in inguinal white adipose tissue (iWAT). However, overexpression of lncRNA 2310069B03Rik suppressed the Ucp1 mRNA expression and the promoter activity of UCP1 in the iWAT primary adipocytes. In addition, compared to the early induction of Ucp1 expression by cold stimulation, the induction of lncRNA 2310069B03Rik expression was later. These results suggest that lncRNA 2310069B03Rik functions as a suppression factor of Ucp1 expression.

    DOI: 10.1080/09168451.2019.1677451

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  • Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Reviewed International journal

    Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno, Asuka Kamio, Yoko Hayashi-Takanaka, Hiromi Wada, Shinzo Ohta, Masanori Aikawa, Hiroyuki Nakajima, Masaki Nakamura, Rebecca C McGee, Kyle W Heppner, Tatsuo Kawakatsu, Michiru Genno, Hiroshi Yanase, Haruki Kume, Takaaki Senbonmatsu, Yukio Homma, Shigeyuki Nishimura, Toutai Mitsuyama, Hiroyuki Aburatani, Hiroshi Kimura, Katsuhiko Shirahige

    Epigenetics & chromatin   12 ( 1 )   77 - 77   2019.12

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    BACKGROUND: Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. The underlying molecular mechanisms responsible for the diverse phenotypes of ECs from different organs are not well understood. RESULTS: To characterize the transcriptomic and epigenomic landscape in the vascular system, we cataloged gene expression and active histone marks in nine types of human ECs (generating 148 genome-wide datasets) and carried out a comprehensive analysis with chromatin interaction data. We developed a robust procedure for comparative epigenome analysis that circumvents variations at the level of the individual and technical noise derived from sample preparation under various conditions. Through this approach, we identified 3765 EC-specific enhancers, some of which were associated with disease-associated genetic variations. We also identified various candidate marker genes for each EC type. We found that the nine EC types can be divided into two subgroups, corresponding to those with upper-body origins and lower-body origins, based on their epigenomic landscape. Epigenomic variations were highly correlated with gene expression patterns, but also provided unique information. Most of the deferentially expressed genes and enhancers were cooperatively enriched in more than one EC type, suggesting that the distinct combinations of multiple genes play key roles in the diverse phenotypes across EC types. Notably, many homeobox genes were differentially expressed across EC types, and their expression was correlated with the relative position of each organ in the body. This reflects the developmental origins of ECs and their roles in angiogenesis, vasculogenesis and wound healing. CONCLUSIONS: This comprehensive analysis of epigenome characterization of EC types reveals diverse transcriptional regulation across human vascular systems. These datasets provide a valuable resource for understanding the vascular system and associated diseases.

    DOI: 10.1186/s13072-019-0319-0

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  • Improvement of detection performance of fusion genes from RNA-seq data by clustering short reads Reviewed International journal

    Sota Y, Seno S, Shigeta H, Osato N, Shimoda M, Noguchi S, Matsuda H

    Journal of Bioinformatics and Computational Biology   17 ( 03 )   1940008 - 1940008   2019

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    Fusion genes are involved in cancer, and their detection using RNA-Seq is insufficient given the relatively short reading length. Therefore, we proposed a shifted short-read clustering (SSC) method, which focuses on overlapping reads from the same loci and extends them as a representative sequence. To verify their usefulness, we applied the SSC method to RNA-Seq data from four types of cell lines (BT-474, MCF-7, SKBR-3, and T-47D). As the slide width of the SSC method increased to one, two, five, or ten bases, the read length was extended from 201 bases to 217 (108%), 234 (116%), 282 (140%), or 317 (158%) bases, respectively. Furthermore, fusion genes were investigated using STAR-Fusion, a fusion gene detection tool, with and without the SSC method. When one base was shifted by the SSC method, the reads mapped to multiple loci decreased from 9.7% to 4.6%, and the sensitivity of the fusion gene was improved from 47% to 54% on average (BT-474: from 48% to 57%, MCF-7: 49% to 53%, SKBR-3: 50% to 57%, and T-47D: 43% to 50%) compared with original data. When the reads are shifted more, the positive predictive value was also improved. The SSC method could be an effective method for fusion gene detection.

    DOI: 10.1142/S0219720019400080

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  • Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity Reviewed

    Sharma A, Osato N, Liu H, Asthana S, Dakal TC, Ambrosini G, Bucher P, Schmit I, Wullmer U

    Scientific Report   9 ( 18464 )   2019

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    DOI: 10.1038/s41598-019-54865-w

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  • The DPP-4 inhibitor, teneligliptin enhances brown adipose tissue function, leading to the prevention of obesity in mice Reviewed

    Takeda K, Sawazaki H, Takahashi H, Yeh YS, Jheng HF, Nomura W, Ara T, Takahashi N, Seno S, Osato N, Matsuda H, Kawata T, Goto T

    FEBS Open Bio   2018.7

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    DOI: 10.1002/2211-5463.12498

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  • Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes Reviewed

    Naoki Osato

    BMC Genomics   19 ( 957 )   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BioMed Central Ltd.  

    DOI: 10.1186/s12864-017-4339-5

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  • Detection of Fusion Genes from Human Breast Cancer Cell-line RNA-Seq Data Using Shifted Short Read Clustering Reviewed

    Yoshiaki Sota, Shigeto Seno, Hironori Shigeta, Naoki Osato, Masafumi Shimoda, Shinzaburo Noguchi, Hideo Matsuda

    PROCEEDINGS 2018 IEEE 18TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE)   159 - 162   2018

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    DOI: 10.1109/BIBE.2018.00038

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  • Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells Reviewed

    Haruka Sasaki, Daisuke Kurotaki, Naoki Osato, Hideaki Sato, Izumi Sasaki, Shin-ichi Koizumi, Hongsheng Wang, Chika Kaneda, Akira Nishiyama, Tsuneyasu Kaisho, Hiroyuki Aburatani, Herbert C. Morse, Keiko Ozato, Tomohiko Tamura

    BLOOD   125 ( 2 )   358 - 369   2015.1

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    DOI: 10.1182/blood-2014-02-557983

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  • Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation Reviewed

    Daisuke Kurotaki, Naoki Osato, Akira Nishiyama, Michio Yamamoto, Tatsuma Ban, Hideaki Sato, Jun Nakabayashi, Marina Umehara, Noriko Miyake, Naomichi Matsumoto, Masatoshi Nakazawa, Keiko Ozato, Tomohiko Tamura

    BLOOD   121 ( 10 )   1839 - 1849   2013.3

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    DOI: 10.1182/blood-2012-06-437863

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  • Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. Reviewed

    Tabuchi TM, Deplancke B, Osato N, Zhu LJ, Barrasa MI, Harrison MM, Horvitz HR, Walhout AJ, Hagstrom KA

    PLoS genetics   7 ( 5 )   e1002074   2011.5

  • Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex Reviewed

    Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua J. Zhu, M. Inmaculada Barrasa, Melissa M. Harrison, H. Robert Horvitz, Albertha J. M. Walhout, Kirsten A. Hagstrom

    PLOS GENETICS   7 ( 5 )   2011.5

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    DOI: 10.1371/journal.pgen.1002074

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  • The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts Reviewed

    Chisato Yamasaki, Katsuhiko Murakami, Yasuyuki Fujii, Yoshiharu Sato, Erimi Harada, Jun-Ichi Takeda, Takayuki Taniya, Ryuichi Sakate, Shingo Kikugawa, Makoto Shimada, Motohiko Tanino, Kanako O. Koyanagi, Roberto A. Barrero, Craig Gough, Hong-Woo Chun, Takuya Habara, Hideki Hanaoka, Yosuke Hayakawa, Phillip B. Hilton, Yayoi Kaneko, Masako Kanno, Yoshihiro Kawahara, Toshiyuki Kawamura, Akihiro Matsuya, Naoki Nagata, Kensaku Nishikata, Akiko Ogura Noda, Shin Nurimoto, Naomi Saichi, Hiroaki Sakai, Ryoko Sanbonmatsu, Rie Shiba, Mami Suzuki, Kazuhiko Takabayashi, Aiko Takahashi, Takuro Tamura, Masayuki Tanaka, Susumu Tanaka, Fusano Todokoro, Kaori Yamaguchi, Naoyuki Yamamoto, Toshihisa Okido, Jun Mashima, Aki Hashizume, Lihua Jin, Kyung-Bum Lee, Yi-Chueh Lin, Asami Nozaki, Katsunaga Sakai, Masahito Tada, Satoru Miyazaki, Takashi Makino, Hajime Ohyanagi, Naoki Osato, Nobuhiko Tanaka, Yoshiyuki Suzuki, Kazuho Ikeo, Naruya Saitou, Hideaki Sugawara, Claire O'Donovan, Tamara Kulikova, Eleanor Whitfield, Brian Halligan, Mary Shimoyama, Simon Twigger, Kei Yura, Kouichi Kimura, Tomohiro Yasuda, Tetsuo Nishikawa, Yutaka Akiyama, Chie Motono, Yuri Mukai, Hideki Nagasaki, Makiko Suwa, Paul Horton, Reiko Kikuno, Osamu Ohara, Doron Lancet, Eric Eveno, Esther Graudens, Sandrine Imbeaud, Marie Anne Debily, Yoshihide Hayashizaki, Clara Amid, Michael Han, Andreas Osanger, Toshinori Endo, Michael A. Thomas, Mika Hirakawa, Wojciech Makalowski, Mitsuteru Nakao, Nam-Soon Kim, Hyang-Sook Yoo, Sandro J. De Souza, Maria de Fatima Bonaldo, Yoshihito Niimura, Vladimir Kuryshev, Ingo Schupp, Stefan Wiemann, Matthew Bellgard, Masafumi Shionyu, Libin Jia, Danielle Thierry-Mieg, Jean Thierry-Mieg, Lukas Wagner, Qinghua Zhang, Mitiko Go, Shinsei Minoshima, Masafumi Ohtsubo, Kousuke Hanada, Peter Tonellato, Takao Isogai, Ji Zhang, Boris Lenhard, Sangsoo Kim, Zhu Chen, Ursula Hinz, Anne Estreicher, Kenta Nakai, Izabela Makalowska, Winston Hide, Nicola Tiffin, Laurens Wilming, Ranajit Chakraborty, Marcelo Bento Soares, Maria Luisa Chiusano, Yutaka Suzuki, Charles Auffray, Yumi Yamaguchi-Kabata, Takeshi Itoh, Teruyoshi Hishiki, Satoshi Fukuchi, Ken Nishikawa, Sumio Sugano, Nobuo Nomura, Yoshio Tateno, Tadashi Imanishi, Takashi Gojobori

    NUCLEIC ACIDS RESEARCH   36 ( Database issue )   D793 - D799   2008.1

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    DOI: 10.1093/nar/gkm999

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  • Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like Reviewed

    Saori Nagayoshi, Eriko Hayashi, Gembu Abe, Naoki Osato, Kazuhide Asakawa, Akihiro Urasaki, Kazuki Horikawa, Kazuho Ikeo, Hiroyuki Takeda, Koichi Kawakami

    DEVELOPMENT   135 ( 1 )   159 - 169   2008.1

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    DOI: 10.1242/dev.009050

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  • The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra Reviewed

    Jung Shan Hwang, Hajime Ohyanagi, Shiho Hayakawa, Naoki Osato, Chiemi Nishimiya-Fujisawa, Kazuho Ikeo, Charles N. David, Toshitaka Fujisawa, Takashi Gojobori

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   104 ( 37 )   14735 - 14740   2007.9

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    DOI: 10.1073/pnas.0703331104

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  • Transcriptional interferences in cis natural antisense transcripts of humans and mice Reviewed

    Naoki Osato, Yoshiyuki Suzuki, Kazuho Ikeo, Takashi Gojobori

    GENETICS   176 ( 2 )   1299 - 1306   2007.6

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    DOI: 10.1534/genetics.106.069484

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  • Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana: The Rice Annotation Project Reviewed

    Takeshi Itoh, Tsuyoshi Tanaka, Roberto A. Barrero, Chisato Yamasaki, Yasuyuki Fujii, Phillip B. Hilton, Baltazar A. Antonio, Hideo Aono, Rolf Apweiler, Richard Bruskiewich, Thomas Bureau, Frances Burr, Antonio Costa De Oliveira, Galina Fuks, Takuya Habara, Georg Haberer, Bin Han, Erimi Harada, Aiko T. Hiraki, Hirohiko Hirochika, Douglas Hoen, Hiroki Hokari, Satomi Hosokawa, Yue-Ie Hsing, Hiroshi Ikawa, Kazuho Ikeo, Tadashi Imanishi, Yukiyo Ito, Pankaj Jaiswal, Masako Kanno, Yoshihiro Kawahara, Toshiyuki Kawamura, Hiroaki Kawashima, Jitendra P. Khurana, Shoshi Kikuchi, Setsuko Komatsu, Kanako O. Koyanagi, Hiromi Kubooka, Damien Lieberherr, Yao-Cheng Lin, David Lonsdale, Takashi Matsumoto, Akihiro Matsuya, W. Richard McCombie, Joachim Messing, Akio Miyao, Nicola Mulder, Yoshiaki Nagamura, Jongmin Nam, Nobukazu Namiki, Hisataka Numa, Shin Nurimoto, Claire O'Donovan, Hajime Ohyanagi, Toshihisa Okido, Satoshi OOta, Naoki Osato, Lance E. Palmer, Francis Quetier, Saurabh Raghuvanshi, Naomi Saichi, Hiroaki Sakai, Yasumichi Sakai, Katsumi Sakata, Tetsuya Sakurai, Fumihiko Sato, Yoshiharu Sato, Heiko Schoof, Motoaki Seki, Michie Shibata, Yuji Shimizu, Kazuo Shinozaki, Yuji Shinso, Nagendra K. Singh, Brian Smith-White, Jun-Ichi Takeda, Motohiko Tanino, Tatiana Tatusova, Supat Thongjuea, Fusano Todokoro, Mika Tsugane, Akhilesh K. Tyagi, Apichart Vanavichit, Aihui Wang, Rod A. Wing, Kaori Yamaguchi, Mayu Yamamoto, Naoyuki Yamamoto, Yeisoo Yu, Hao Zhang, Qiang Zhao, Kenichi Higo, Benjamin Burr, Takashi Gojobori, Takuji Sasaki

    Genome Research   17 ( 2 )   175 - 183   2007.2

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    DOI: 10.1101/gr.5509507

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  • Development of a Computer-Based Method for a Full-Length cDNA Project and Discovery of Cis Sense-Antisense mRNAs with Full-Length cDNAs Reviewed

    Naoki Osato

    Doctoral thesis   2007

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  • A genome-wide and nonredundant mouse transcription factor database Reviewed

    M Kanamori, H Konno, N Osato, J Kawai, Y Hayashizaki, H Suzuki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   322 ( 3 )   787 - 793   2004.9

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    DOI: 10.1016/j.bbrc.2004.07.179

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  • Identification of region-specific transcription factor genes in the adult mouse brain by medium-scale real-time RT-PCR Reviewed

    H Suzuki, R Okunishi, W Hashizume, S Katayama, N Ninomiya, N Osato, K Sato, M Nakamura, J Iida, M Kanamori, Y Hayashizaki

    FEBS LETTERS   573 ( 1-3 )   214 - 218   2004.8

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    DOI: 10.1016/j.febslet.2004.07.068

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  • Antisense transcripts with rice full-length cDNAs Reviewed

    N Osato, H Yamada, K Satoh, H Ooka, M Yamamoto, K Suzuki, J Kawai, P Carninci, Y Ohtomo, K Murakami, K Matsubara, S Kikuchi, Y Hayashizaki

    GENOME BIOLOGY   5 ( 1 )   2004

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  • Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana Reviewed

    H Ooka, K Satoh, K Doi, T Nagata, Y Otomo, K Murakami, K Matsubara, N Osato, J Kawai, P Carninci, Y Hayashizaki, K Suzuki, K Kojima, Y Takahara, K Yamamoto, S Kikuchi

    DNA RESEARCH   10 ( 6 )   239 - 247   2003.12

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    DOI: 10.1093/dnares/10.6.239

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  • Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice Reviewed

    S Kikuchi, K Satoh, T Nagata, N Kawagashira, K Doi, N Kishimoto, J Yazaki, M Ishikawa, H Yamada, H Ooka, Hotta, I, K Kojima, T Namiki, E Ohneda, W Yahagi, K Suzuki, CJ Li, K Ohtsuki, T Shishiki, Y Otomo, K Murakami, Y Iida, S Sugano, T Fujimura, Y Suzuki, Y Tsunoda, T Kurosaki, T Kodama, H Masuda, M Kobayashi, QH Xie, M Lu, R Narikawa, A Sugiyama, K Mizuno, S Yokomizo, J Niikura, R Ikeda, J Ishibiki, M Kawamata, A Yoshimura, J Miura, T Kusumegi, M Oka, R Ryu, M Ueda, K Matsubara, J Kawai, P Carninci, J Adachi, K Aizawa, T Arakawa, S Fukuda, A Hara, W Hashizume, N Hayatsu, K Imotani, Y Ishii, M Itoh, Kagawa, I, S Kondo, H Konno, A Miyazaki, N Osato, Y Ota, R Saito, D Sasaki, K Sato, K Shibata, A Shinagawa, T Shiraki, M Yoshino, Y Hayashizaki, A Yasunishi

    SCIENCE   301 ( 5631 )   376 - 379   2003.7

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    DOI: 10.1126/science.1081288

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  • Antisense transcripts with FANTOM2 clone set and their implications for gene regulation Reviewed

    H Kiyosawa, Yamanaka, I, N Osato, S Kondo, Y Hayashizaki

    GENOME RESEARCH   13 ( 6B )   1324 - 1334   2003.6

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  • Targeting a complex transcriptome: The construction of the mouse full-length cDNA encyclopedia Reviewed

    P Carninci, K Waki, T Shiraki, H Konno, K Shibata, M Itoh, K Aizawa, T Arakawa, Y Ishii, D Sasaki, H Bono, S Kondo, Y Sugahara, R Saito, N Osato, S Fukuda, K Sato, A Watahiki, T Hirozane-Kishikawa, M Nakamura, Y Shibata, A Yasunishi, N Kikuchi, A Yoshiki, M Kusakabe, S Gustincich, K Beisel, W Pavan, Aidinis, V, A Nakagawara, WA Held, H Iwata, T Kono, H Nakauchi, P Lyons, C Wells, DA Hume, M Fagiolini, TK Hensch, M Brinkmeier, S Camper, J Hirota, P Mombaerts, M Muramatsu, Y Okazaki, J Kawai, Y Hayashizaki

    GENOME RESEARCH   13 ( 6B )   1273 - 1289   2003.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1101/gr.1119703

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  • Antisense transcripts with rice full-length cDNAs. Reviewed

    Osato N, Yamada H, Satoh K, Ooka H, Yamamoto M, Suzuki K, Kawai J, Carninci P, Ohtomo Y, Murakami K, Matsubara K, Kikuchi S, Hayashizaki Y

    Genome biology   5 ( 1 )   R5   2003

  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs Reviewed

    Y Okazaki, M Furuno, T Kasukawa, J Adachi, H Bono, S Kondo, Nikaido, I, N Osato, R Saito, H Suzuki, Yamanaka, I, H Kiyosawa, K Yagi, Y Tomaru, Y Hasegawa, A Nogami, C Schonbach, T Gojobori, R Baldarelli, DP Hill, C Bult, DA Hume, J Quackenbush, LM Schriml, A Kanapin, H Matsuda, S Batalov, KW Beisel, JA Blake, D Bradt, Brusic, V, C Chothia, LE Corbani, S Cousins, E Dalla, TA Dragani, CF Fletcher, A Forrest, KS Frazer, T Gaasterland, M Gariboldi, C Gissi, A Godzik, J Gough, S Grimmond, S Gustincich, N Hirokawa, IJ Jackson, ED Jarvis, A Kanai, H Kawaji, Y Kawasawa, RM Kedzierski, BL King, A Konagaya, Kurochkin, IV, Y Lee, B Lenhard, PA Lyons, DR Maglott, L Maltais, L Marchionni, L McKenzie, H Miki, T Nagashima, K Numata, T Okido, WJ Pavan, G Pertea, G Pesole, N Petrovsky, R Pillai, JU Pontius, D Qi, S Ramachandran, T Ravasi, JC Reed, DJ Reed, J Reid, BZ Ring, M Ringwald, A Sandelin, C Schneider, CAM Semple, M Setou, K Shimada, R Sultana, Y Takenaka, MS Taylor, RD Teasdale, M Tomita, R Verardo, L Wagner, C Wahlestedt, Y Wang, Y Watanabe, C Wells, LG Wilming, A Wynshaw-Boris, M Yanagisawa, Yang, I, L Yang, Z Yuan, M Zavolan, Y Zhu, A Zimmer, P Carninci, N Hayatsu, T Hirozane-Kishikawa, H Konno, M Nakamura, N Sakazume, K Sato, T Shiraki, K Waki, J Kawai, K Aizawa, T Arakawa, S Fukuda, A Hara, W Hashizume, K Imotani, Y Ishii, M Itoh, Kagawa, I, A Miyazaki, K Sakai, D Sasaki, K Shibata, A Shinagawa, A Yasunishi, M Yoshino, R Waterston, ES Lander, J Rogers, E Birney, Y Hayashizaki

    NATURE   420 ( 6915 )   563 - 573   2002.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature01266

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  • A computer-based method of selecting clones for a full-length cDNA project: Simultaneous collection of negligibly redundant and variant cDNAs Reviewed

    N Osato, M Itoh, H Konno, S Kondo, K Shibata, P Carninci, T Shiraki, A Shinagawa, T Arakawa, S Kikuchi, K Sato, J Kawai, Y Hayashizaki

    GENOME RESEARCH   12 ( 7 )   1127 - 1134   2002.7

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    DOI: 10.1101/gr.75202

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  • Removal of polyA tails from full-length cDNA libraries for high-efficiency sequencing Reviewed

    Shibata, I, P Carninci, K Sato, N Hayatsu, T Shiraki, Y Ishii, T Arakawa, A Hara, N Ohsato, M Izawa, K Aizawa, M Itoh, K Shibata, A Shinagawa, J Kawai, Y Ota, S Kikuchi, N Kishimoto, M Muramatsu, Y Hayashizaki

    BIOTECHNIQUES   31 ( 5 )   1042 - +   2001.11

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  • Clustering of Full-Length cDNA Clones Based on Both End Sequences Reviewed

    Osato Naoki, Konno Hideki, Itoh Masayoshi, Condo Shinji, Kawai Jun, Shibata Kazuhiro, Shinagawa Akira, Apache Jun, Fukuda Shiro, Ota Yoshimi, Hayashizaki Yoshihide

    Genome Informatics   11   374 - 375   2000

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    Language:English   Publisher:Japanese Society for Bioinformatics  

    DOI: 10.11234/gi1990.11.374

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Books

  • Cell type–specific functions of nucleic acid-binding proteins revealed by deep learning on co-expression networks.

    Naoki Osato, Kengo Sato

    情報処理学会研究報告 Vol.2025-BIO-82 No.62  2025.6 

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  • ヒトの遺伝子発現制御の相互作用を遺伝子発現量やゲノムDNA配列から予測する手法の開発

    大里直樹

    情報処理学会研究報告 Vol.2025-BIO-81 No.17  2025.3 

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  • ヒト遺伝子発現制御のインシュレータと関わるDNA結合タンパク質の発見

    大里直樹

    情報処理学会 第87回全国大会講演論文集  2025.3 

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  • ヒト遺伝子発現制御のインシュレータ機能に関わる DNA 結合タンパク質の解析と応用

    大里直樹( Role: Sole author)

    情報処理学会研究報告 Vol.2024-BIO-79 No.3  2024.9 

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  • ヒト遺伝子発現制御のインシュレータと関わるDNA結合タンパク質の発見

    大里直樹, 浜田道昭( Role: Sole author)

    情報処理学会第86回全国大会講演論文集  2024.3 

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  • Topics 機械学習による遺伝子転写制御に関わる因子の探索

    大里直樹、浜田道昭( Role: Sole author)

    月刊細胞, ニューサイエンス社  2022.11 

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  • Topics 実験データ解析と機械学習による転写制御因子の探索、特集 エピトランスクリプトミクス

    大里直樹、浜田道昭

    月刊細胞、ニューサイエンス社  2021.12 

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  • Topics 実験データ解析による転写制御因子の探索、特集 ゲノムデータを駆使した医学研究

    大里直樹( Role: Sole author)

    月刊細胞、ニューサイエンス社  2021.7 

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  • Bioinformatics Approaches for Determining the Functional Impact of Repetitive Elements on Non-coding RNAs

    Chao Zeng, Atsushi Takeda, Kotaro Sekine, Naoki Osato, Tsukasa Fukunaga, Michiaki Hamada( Role: Joint author)

    Preprints  2021 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する方向性のある転写因子DNA結合配列の解析法の開発

    大里直樹, 浜田道昭

    情報処理学会研究報告 Vol.2021-BIO-67 No.6  2021 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する方向性のある転写因子DNA結合配列の解析法の開発

    大里直樹, 浜田道昭

    情報処理学会研究報告 Vol.2021-BIO-68 No.2  2021 

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  • Characteristic of functional enrichments of putative transcriptional target genes and its application

    Naoki Osato

    IPSJ SIG Technical Report, Vol.2017-BIO-52 No.1  2017 

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  • ゲノムの進化、淘汰、中立 生物の科学 遺伝別冊No.20 進化でどこまでわかるか?

    Giorgio Bernardi 著, 大里直樹, 五條堀孝

    NTS  2007 

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  • Genome Science of Vertebrate

    Osato N, Kiyosawa H, Kawai J, Hayashizaki Y

    EOLSS (The Encyclopedia of Life Support Systems), UNESCO  2004 

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    Responsible for pages:264-278  

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  • 解読されたゲノム情報をどう活かすか 現代化学増刊40号

    近藤伸二, 大里直樹( Role: Joint author3. ヒト総遺伝子数)

    東京化学同人  2001 

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    Responsible for pages:19-23   Language:Japanese   Book type:Scholarly book

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  • 分子生物学のためのバイオインフォマティクス入門

    大里直樹( Role: Sole translator第9章 エピローグ:DNAを用いたコンピュータ)

    共立出版株式会社  2001 

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    Responsible for pages:241-254  

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Presentations

  • Cell type–specific functions of nucleic acid-binding proteins revealed by deep learning on co-expression networks.

    Naoki Osato, Kengo Sato

    第82回バイオ情報学研究会  2025.6 

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  • ヒト遺伝子発現制御のインシュレータと関わる DNA結合タンパク質の発見

    大里直樹

    情報処理学会 第87回全国大会  2025.3 

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    Event date: 2025.3

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  • ヒトの遺伝子発現制御の相互作用を遺伝子発現量やゲノムDNA配列から予測する手法の開発

    大里直樹

    第81回バイオ情報学研究会  2025.3 

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    Event date: 2025.3

    Presentation type:Oral presentation (general)  

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  • ヒト遺伝子発現制御のインシュレータと関わるDNA結合タンパク質の発見

    大里直樹

    第47回日本分子生物学会年会  2024.11 

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  • Systematic discovery of directional regulatory motifs associated with human insulator sites

    Naoki Osato

    1st Asia & Pacific Bioinformatics Joint Conference (APBJC)  2024.10 

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    Event date: 2024.10

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  • AI-based interaction analysis between DNA/RNA-binding proteins and genes from gene expression correlation

    Naoki Osato

    1st Asia & Pacific Bioinformatics Joint Conference (APBJC)  2024.10 

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  • Systematic discovery of regulatory motifs associated with an insulator function for human enhancer-promoter interactions

    Naoki Osato, Michiaki Hamada

    ERATO International Symposium on Chromatin Architecture: Structure and Function  2023.1 

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    Event date: 2023.1

    Presentation type:Poster presentation  

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  • ヒト遺伝子発現制御のインシュレータ機能に関わる転写因子の予測と発見

    大里直樹, 浜田道昭

    第45回日本分子生物学会年会  2022.11 

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    Event date: 2022.11 - 2022.12

    Presentation type:Poster presentation  

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  • ヒト遺伝子発現制御のインシュレータ機能に関わる転写因子の予測と発見

    大里直樹, 浜田道昭

    第45回日本分子生物学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Presentation type:Oral presentation (invited, special)  

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  • ヒト遺伝子発現制御のインシュレータ機能に関わる転写因子の予測と発見

    大里直樹, 浜田道昭

    日本遺伝学会第94回大会  2022.9 

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    Event date: 2022.9

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  • Systematic discovery of regulatory motifs associated with the insulator function of human enhancer-promoter interactions

    2022.9 

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  • Systematic discovery of regulatory motifs associated with the insulator function of human enhancer-promoter interactions

    Naoki Osato, Michiaki Hamada

    Intelligent Systems for Molecular Biology (ISMB)  2022.7 

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    Event date: 2022.7

    Presentation type:Oral presentation (general)  

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の解析法の開発

    大里直樹、浜田道昭

    第44回日本分子生物学会年会  2021.12 

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    Event date: 2021.12

    Presentation type:Poster presentation  

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  • 深層学習を用いた、ヒトのエンハンサー・遺伝子相互作用に影響する転写因子の解析.

    大里直樹, 浜田道昭

    JST CREST 「データ駆動・AI駆動を中心としたデジタルトランスフォーメーションによる生命科学研究の革新[バイオDX]」 キックオフシンポジウム「バイオDXの最前線  2021.11 

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    Event date: 2021.11

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  • 深層学習の予測結果に寄与する因子の大規模な解析に伴うノイズの影響の低減

    大里直樹、浜田道昭

    第24回情報論的学習理論ワークショップ  2021.11 

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  • 脂肪細胞におけるSTAT3を介したUCP1発現制御機構の解明

    疋田菜光, 岩瀬麻里, 川原崎聡子, 酒井章子, 坂本智弥, 大里直樹, 瀬尾茂人, 野村亘, 野村亘, 高橋春弥, 松田秀雄, 井上和生, 井上和生, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集  2020 

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  • 脂肪組織におけるglycerol kinaseのUcp1発現制御機構

    岩瀬 麻里, 常盤 颯志, 瀬尾 茂人, 向井 貴子, 高橋 春弥, 野村 亘, Jheng Huei-Fen, 楠堂 達也, 大里 直樹, 松田 秀雄, 井上 和生, 河田 照雄, 後藤 剛

    肥満研究  2019.10  (一社)日本肥満学会

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    Event date: 2019.10

    Language:Japanese  

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  • 白色脂肪組織の褐色化に対するglycerol kinaseの役割

    岩瀬麻里, 常盤颯志, 瀬尾茂人, 向井貴子, 高橋春弥, 野村亘, 野村亘, JHENG Huei‐Fen, 荒武, 楠堂達也, 大里直樹, 松田秀雄, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    日本栄養・食糧学会大会講演要旨集  2019.4 

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    Event date: 2019.4

    Language:Japanese  

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  • IL‐1βが白色脂肪組織におけるUCP1発現誘導に及ぼす影響の検討

    新谷真和, 吉竹里依子, 岩瀬麻里, 高橋春弥, 野村亘, JHENG Huie‐Fun, 荒武, 大里直樹, 瀬尾茂人, 松田秀雄, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    肥満研究  2018.9 

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    Event date: 2018.9

    Language:Japanese  

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  • DPP‐4阻害剤テネリグリプチンが脂肪組織のUCP‐1発現に与える影響

    澤崎穂菜美, 武田健一郎, 高橋春弥, 野村亘, 野村亘, JHENG Huei‐fen, 荒武, 高橋信之, 高橋信之, 大里直樹, 瀬尾茂人, 松田秀雄, 河田照雄, 後藤剛

    日本農芸化学会大会講演要旨集(Web)  2018.3 

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    Event date: 2018.3

    Language:Japanese  

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  • Ucp1発現を制御するnon‐coding RNAの探索と機能解析

    岩瀬麻里, 酒井章子, 瀬尾茂人, TONY Kuo, 高橋春弥, 野村亘, 野村亘, JHENG Huie‐Fun, 荒武, PAUL Horton, 大里直樹, 松田秀雄, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    日本農芸化学会大会講演要旨集(Web)  2018.3 

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    Language:Japanese  

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  • 褐色脂肪細胞機能におけるglycerol kinaseの役割

    岩瀬麻里, 常盤颯志, 高橋春弥, 野村亘, 野村亘, JHENG Huei-Fun, 荒武, 大里直樹, 瀬尾茂人, 松田秀雄, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    日本食品科学工学会関西支部大会市民フォーラム講演要旨集  2018 

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  • 発現制御に関するmiRNAの探索及び機能解析

    酒井章子, 大久保麻里, 高橋春弥, 野村亘, 野村亘, JHENG Huie‐Fen, 荒武, 瀬尾茂人, 大里直樹, 松田秀雄, 河田照雄, 河田照雄, 後藤剛, 後藤剛

    日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集  2017.11 

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    Language:Japanese  

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  • A ROLE OF THE TRANSCRIPTION FACTOR IRF8 IN BASOPHIL AND MAST CELL DEVELOPMENT

    Haruka Sasaki, Daisuke Kurotaki, Naoki Osato, Hideaki Sato, Izumi Sasaki, Shin-ichi Koizumi, Hongsheng Wang, Chika Kaneda, Akira Nishiyama, Tsuneyasu Kaisho, Hiroyuki Aburatani, Herbert C. Morse, Keiko Ozato, Tomohiko Tamura

    EXPERIMENTAL HEMATOLOGY  2015.9  ELSEVIER SCIENCE INC

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    Event date: 2015.9

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  • The Transcription Factor IRF8 is a Key Transcription Factor for Basophil Development

    Daisuke Kurotaki, Haruka Sasaki, Naoki Osato, Izumi Sasaki, Chika Kaneda, Hideaki Sato, Akira Nishiyama, Tsuneyasu Kaisho, Hiroyuki Aburatani, Herbert C. Morse, Keiko Ozato, Tomohiko Tamura

    BLOOD  2013.11  AMER SOC HEMATOLOGY

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  • The IRF8-KLF4 transcription factor cascade is essential for the development of monocytes

    Daisuke Kurotaki, Naoki Osato, Akira Nishiyama, Michio Yamamoto, Tatsuma Ban, Hideaki Sato, Jun Nakabayashi, Marina Umehara, Masatoshi Nakazawa, Noriko Miyake, Naomichi Matsumoto, Keiko Ozato, Tomohiko Tamura

    CYTOKINE  2013.9  ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

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  • Identification and characterization of human overlapping transcripts that affect their expression

    Naoki Osato, Takashi Gojobori

    GENES & GENETIC SYSTEMS  2007.12  GENETICS SOC JAPAN

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  • Chromatin accessibility dynamics reveal decrease of DNA motif sequences of transcription factors during macrophage aging International conference

    Naoki Osato

    International Meeting on RECQ Helicases and Related Diseases  2018 

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  • Discovery of biased orientation of DNA motif sequences affecting human gene expression for prediction of enhancer-promoter interactions International conference

    Naoki Osato

    Human Genome Meeting 2018  2018 

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  • UCP1発現制御に関するmiRNAの探索及び機能解析

    酒井章子

    第56回日本栄養・食糧学会年会  2017 

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  • DPP-4阻害剤テネリグリプチンが脂肪組織のUCP-1発現に与える影響

    澤崎穂菜美

    農芸化学学会年会  2017 

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  • Ucp1発現を制御するnon-coding RNAの探索と機能解析

    岩瀬麻里

    農芸化学学会年会  2017 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の発見

    大里直樹

    第7回生命医薬情報学連合大会(IIBMP)  2018.9 

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  • Characteristics of human putative transcriptional target genes and discovery of biased orientation of DNA motifs affecting transcription of genes International conference

    Naoki Osato

    Intelligent Systems for Molecular Biology (ISMB)  2019.7 

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  • A method for inferring gene regulatory networks based on pseudo time-series gene expression profiles from single-cell RNA-seq data International conference

    Kaito Uemura, Naoki Osato, Hironori Shigeta, Shigeto Seno, Hideo Matsuda

    Intelligent Systems for Molecular Biology (ISMB)  2019.7 

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  • Single-cell transcriptome analysis for elucidating cell dynamics International conference

    Naoki Osato, Hironori Shigeta, Shigeto Seno, Yutaka Uchida, Masaru Ishii, Hideo Matsuda

    12th international workshop on approaches to single cell analysis  2019.3 

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  • ヒト転写因子の標的遺伝子の特徴とエンハンサー・遺伝子相互作用に関わる転写因子解析

    大里 直樹

    遺伝学会春季分科会  2019.3 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の発見

    大里直樹

    第41回日本分子生物学会年会  2018.11 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の発見

    大里直樹

    日本遺伝学会第90回大会  2018.9 

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  • ヒト転写因子の転写標的遺伝子の特徴とエンハンサー・遺伝子相互作用に関わる転写因子解析

    大里 直樹

    日本遺伝学会第91回大会  2019.9 

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  • ヒト転写因子の標的遺伝子の特徴とエンハンサー・遺伝子相互作用に関わる転写因子解析 Invited

    大里 直樹

    第8回生命医薬情報学連合大会年会  2019.9 

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  • Systematic discovery of directional chromatin-associated regulatory motifs affecting human gene transcription

    Naoki Osato

    Intelligent Systems for Molecular Biology (ISMB)  2021.7 

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  • ヒトのオープンクロマチン領域に存在する転写因子DNA結合配列の網羅的な解析

    大里直樹

    日本遺伝学会第92回大会  2020.9 

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  • ヒト転写因子の標的遺伝子の特徴とエンハンサー・遺伝子相互作用に関わる転写因子解析

    大里直樹

    第9回生命医薬情報学連合大会  2020.9 

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  • Discovery of biased orientations of regulatory motifs affecting transcription of human genes and including known insulators

    Naoki Osato

    Intelligent Systems for Molecular Biology (ISMB) 2020  2020.7 

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  • ヒト転写因子の標的遺伝子の特徴とインシュレータ機能に関わるDNA配列の発見

    大里直樹

    遺伝学会春季分科会  2020.3 

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  • Characteriistic of human putative transcriptional target genes and discovery of biased orientations of DNA motifs affecting transcription of genes.

    Naoki Osato

    2019.12 

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  • Characteristic of human putative transcriptional target genes and discovery of biased orientaions of DNA motifs affecting transcription of genes Invited

    Naoki Osato

    2019.12 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の発見

    大里直樹, 浜田道昭

    第10回生命医薬情報学連合大会  2021.9 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の解析法の開発

    大里直樹, 浜田道昭

    第67回バイオ情報学研究会  2021.9 

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  • 枯草菌α-アミラーゼにおけるカルシウム結合部位変異と塩素イオン結合部位導入による酵素活性への影響

    大里直樹, 藤本瑞, 門間充, 高瀬研二, 水野洋

    第11回日本蛋白工学会年会要旨  1999 

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  • ヒトのエンハンサーと遺伝子相互作用や転写制御に影響する、方向性のある転写因子DNA結合配列の解析法の開発

    大里直樹, 浜田道昭

    第68回バイオ情報学研究会  2021.11 

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  • イネ完全長cDNAの両端配列による分類

    大里直樹, 太田由巳, 福田史郎, 今野英明, 河合純, 伊藤昌可, 柴田一浩, 品川朗, 林崎良英

    第23回日本分子生物学会年会要旨  2000 

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  • Methylation diversity among human vascular endothelial cells International conference

    Genta Nagae, Youichiro Wada, Ryuichiro Nakato, Takayoshi Umeda, Yuki Katou, Shuichi Tsutsumi, Naoki Osato, Yasuharu Kanki, Mika Kobayashi, Akashi Izumi-Taguchi, Yutaka Saito, Toutai Mitsuyma, Hiroshi Kimura, Katsuhiko Shirahige, Hiroyuki Aburatani

    The 12 th International Workshop on Advanced Genomics  2017 

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    Venue:Japan  

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  • 1細胞RNA-seqの特性を考慮した遺伝子発現差解析手法の検討

    大里直樹

    NGS現場の会第五回研究会要旨  2017 

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  • Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes International conference

    Naoki Osato

    International Conference on Bioinformatics (InCoB)  2017 

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    Venue:Shenzhen Convention & Exhibition Center, Shenzhen, China  

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  • Prediction of transcriptional target genes and its association with their functional enrichments

    Naoki Osato

    2016 

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  • Genome-wide analysis of human putative transcriptional target genes reveals significant functional enrichments Invited

    Naoki Osato

    2016 

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  • 遺伝子転写カスケード解明のための統合解析(2)

    大里直樹

    生命動態システム科学四拠点,CREST,PRESTO,QBIC合同シンポジウム「生命動態の分子メカニズムと数理」  2016 

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  • Characteristic of functional enrichment of putative transcriptional target genes and its application

    Naoki Osato

    2017 

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  • ヒト転写標的遺伝子の機能エンリッチメントの特徴とクロマチン相互作用に関わるタンパク質のDNA結合配列解析への応用 Invited

    大里直樹

    第40回日本分子生物学会年会  2017 

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  • Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes (2) International conference

    Naoki Osato

    The 12th International Workshop on Advanced Genomics  2017 

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  • Characteristics of functional enrichment of human putative transcriptional target genes

    Naoki Osato

    2017 

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  • DNA binding activity of C. elegans LIN-54 is essential for DRM complex in transcriptional repression and development International conference

    Tomoko M Tabuchi, Bart Deplancke, Naoki Osato, Lihua J Zhu, M Inmaculada Barrasa, Melissa M Harrison, H Robert Horvitz, Kirsten A Hagstrom, Albertha JM Walhout

    EMBO Conference Series. C. elegans: Development and Gene Expression  2010 

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    Venue:Germany  

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  • 脊椎動物ゲノムのタンパク質非コード領域からのDNAモチーフ配列の探索(3)

    大里直樹, Martin C. Frith

    平成20年度第8回産総研・産技連LS-BT合同研究発表会要旨  2009 

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  • Human short DNA motifs overrepresented in conserved non-protein-coding sequences Invited

    Naoki Osato

    JST BIRD meeting  2009 

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    Venue:東京大学柏キャンパス  

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  • Overrepresented DNA motifs in highly conserved non-protein-coding regions of vertebrate genomes(5) International conference

    Naoki Osato, Martin C. Frith

    The 2nd Taiwan-Japan young researchers conference on computational and systems biology  2008 

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    Venue:Japan  

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  • Overrepresented DNA motifs in highly conserved non-protein-coding regions of vertebrate genomes(4) International conference

    Naoki Osato, Martin C. Frith

    The eighth Cold Spring Harbor Laboratory/Wellcome Trust conference on Genome Informatics  2008 

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    Venue:United Kingdom  

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  • Overrepresented DNA motifs in highly conserved non-protein-coding regions of vertebrate genomes(3)

    Naoki Osato, Martin C. Frith

    CBRC symposium  2008 

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  • 線虫のゲノムワイドな転写制御ネットワーク解析 Invited

    大里直樹

    公益財団法人山田科学振興財団2012年度長期間派遣者研究交歓会  2012 

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    Venue:薬業年金会館  

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  • IRF8 physically interacts with C/EBPa to inhibit the generation of granulocyte-macrophage progenitors and neutrophils

    Tomohiko Tamura, Michio Yamamoto, Naoki Osato, Daisuke Kurotaki, Kazuhiro Uno, Masatoshi Nakazawa, Akira Nishiyama, Keiko Ozato

    第34回日本分子生物学会年会要旨  2011 

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  • Genome-wide analyses of transcriptional regulatory networks in immune cells. Towards Comprehensive Understanding of Immune Dynamism International conference

    Naoki Osato, Nakai Kenta

    Towards Comprehensive Understanding of Immune Dynamism (TCUID 2011)  2011 

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  • 転写制御解析のバイオインフォマティクス Invited

    大里直樹

    バイオインフォマティクスへの招待  2011 

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    Venue:お茶の水女子大学  

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  • The transcription factor IRF8 is a key transcription factor for basophil development International conference

    Daisuke Kurotaki, Haruka Sasaki, Naoki Osato, Izumi Sasaki, Chika Kaneda, Hideaki Sato, Akira Nishiyama, Tsuneyasu Kaisho, Hiroyuki Aburatani, Herbert C. Morse III, Keiko Ozato, Tomohiko Tamura

    55th ASH Annual Meeting and Exposition  2013 

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    Venue:USA  

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  • Functional prediction of transcriptional regulations using epigenetic signatures International conference

    Naoki Osato, Hiroyuki Aburatani

    Cold Spring Harbor Laboratory meeting, Systems Biology: Networks  2013 

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    Venue:USA  

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  • Comparative epigenomic analysis of human vascular endothelial cells

    Naoki Osato, Hiroshi Kimura, Katsuhiko Shirahige, Hiroyuki Aburatani, Youichiro Wada

    第36回日本分子生物学会年会要旨  2013 

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  • The transcription factor IRF8 is required for basophil development

    Haruka Sasaki, Daisuke Kurotaki, Naoki Osato, Izumi Sasaki, Kaneda Chika, Hideaki Sato, Akira Nishiyama, Tsuneyasu Kaisho, Hiroyuki Aburatani, Herbert C. Morse III, Keiko Ozato, Tomohiko Tamura

    第42回日本免疫学会学術集会要旨  2013 

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  • 転写制御解析のためのバイオインフォマティクス Invited

    大里直樹

    バイオインフォマティクス研究会  2013 

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    Venue:横浜市立大学  

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  • Epigenomic analysis from human primary cultivated vascular cells International conference

    Youichiro Wada, Yasuharu Kanki, Naoki Osato, Hiroyuki Aburatani, Katsuhiko Shirahige

    IHEC (International Human Epigenome Consortium) 2012 Seoul Meeting  2012 

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    Venue:Korea  

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  • Genome-wide analyses revealed the IRF8-KLF4 transcription factor cascade during monocyte differentiation

    Daisuke Kurotaki, Naoki Osato, Akira Nishiyama, Michio Yamamoto, Hideaki Sato, Jun Nakabayashi, Tatsuma Ban, Keiko Ozato, Tomohiko Tamura

    第41回日本免疫学会学術集会要旨  2012 

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  • Human transcriptional target genes include significant functional enrichments

    Naoki Osato

    JSBi2014・第3回生命医薬情報学連合大会要旨  2014 

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  • Integrative analysis improves the prediction of key transcription factors and transcriptional activators for cell differentiation International conference

    Naoki Osato

    The 11th International Workshop on Advanced Genomics  2015 

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    Venue:Japan  

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  • 遺伝子転写カスケード解明のための統合解析

    大里直樹

    数学協働プログラム「生命ダイナミクスの数理とその応用:理論からのさらなる深化」  2015 

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  • Genome-wide analysis of human transcriptional target genes reveals significant functional enrichments(2)

    Naoki Osato

    生命医薬情報学連合大会2015年大会要旨  2015 

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  • ヒト転写標的遺伝子の機能の偏りと転写標的遺伝子予測への応用

    大里直樹

    第87日本遺伝学会年会要旨  2015 

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  • Genome-wide analysis of human transcriptional target genes reveals significant functional enrichments, improving the prediction of transcriptional cascades

    Naoki Osato

    第15回東京大学生命科学シンポジウム要旨  2015 

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  • Genome-wide analysis of human transcriptional target genes reveals significant functional enrichments Invited

    Naoki Osato

    Annual Conference of Biochemistry and Molecular Biology  2015 

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    Venue:神戸国際会議場  

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  • ヒト転写制御カスケード解明のための統合解析法の開発 Invited

    大里直樹

    生命医科学域セミナー  2015 

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    Venue:筑波大学  

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  • 遺伝子転写制御のバイオインフォマティクス Invited

    大里直樹

    数理科学と分子生物学を融合する研究・教育のアウトリーチについての研究会  2015 

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    Venue:東京大学・玉原国際セミナーハウス  

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  • Functional enrichment analysis of human transcriptional target genes and its application to their prediction International conference

    Naoki Osato

    IHEC (International Human Epigenome Consortium) Annual Meeting  2015 

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    Venue:Japan  

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  • イネ完全長cDNAのイネゲノムへのマッピング

    近藤伸二, 太田由巳, 今野英明, 河合純, 伊藤昌可, 柴田一浩, 品川朗, 大里直樹, 齋藤哲哉, 林崎良英

    第23回日本分子生物学会年会要旨  2000 

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  • Systematic discovery of regulatory motifs associated with human insulator sites

    Naoki Osato

    Human Genome Meeting (HGM)  2024.4 

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  • イネ完全長cDNAの収集.第23回日本分子生物学会年会要旨

    太田由巳, 河合純, 伊藤昌可, 柴田一浩, 品川朗, カルニンチ ピエロ, 吉野正康, 原亜矢子, 大里直樹, 福田史郎, 早津徳人, 石井善幸, 荒川貴博, 今野英明, 齋藤輪太郎, 相澤克則, 菊池尚志, 大竹祐子, 佐藤浩二, 岸本直己, 林崎良英

    第23回日本分子生物学会年会要旨  2000 

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  • ヒト遺伝子発現制御のインシュレータ機能に関わるDNA結合タンパク質の予測と発見

    大里直樹, 浜田道昭

    情報処理学会 第86回全国大会  2024.3 

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  • イネ完全長cDNAプロジェクト-全長シーケンス決定-

    福田史郎, 河合純, Carninci Piero, 白木利幸, 岸川(広實)朋子, 伊藤昌可, 荒川貴博, 石井善幸, 柴田一浩, 相澤克則, 香川育子, 佐々木大輔, 橋詰航, 芋谷弘一, 宮崎愛, 大里直樹, 今野英明, 足立淳, 近藤伸二, 岸本直己, 佐藤浩二, 菊池尚志, 林崎良英

    第25回日本分子生物学会年会要旨  2002 

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  • イネ完全長cDNAデータを用いた転写因子の比較解析

    大岡久子, 永田俊文, 佐藤浩二, 大友泰裕, 松原謙一, 村上和雄, 大里直樹, 河合純, カルニンチ ピエロ, 林崎良英

    第25回日本分子生物学会年会要旨  2002 

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  • イネ (Oryza sativa) mRNAのpolyA siteの多様性

    佐藤浩二, 小島恵一, 大根田英祐, 矢作渡, 鈴木宏史, 大里直樹, 河合純, カルニンチ ピエロ, 林崎良英, 大友泰裕, 村上和雄, 松原謙一, 山下智也, 東憲児, 鹿島剛輝, 鷲尾尊規, 冨田勝, 菊池尚志

    第25回日本分子生物学会年会要旨  2002 

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  • コンピュータによる転写調節・翻訳調節に関わる因子の同定とその解析 Invited

    大里直樹

    第一回バイオインフォマティクスセミナー  2002 

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    Venue:かずさDNA研究所  

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  • イネ完全長cDNAにおけるUTR領域での多型解析

    佐藤浩二, 小島恵一, 大根田英祐, 矢作渡, 並木高洋, 大里直樹, 河合純, カルニンチ ピエロ, 林崎良英, 大友泰裕, 村上和雄, 松原謙一, 山下智也, 鷲尾尊規, 冨田勝, 菊池尚志

    第24回日本分子生物学会年会要旨  2001 

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  • イネ完全長cDNAプロジェクト-クローン収集とシーケンス決定-

    河合純, カルニンチ ピエロ, 早津徳人, 白木利幸, 広實朋子, 品川朗, 太田由巳, 伊藤昌可, 荒川貴博, 石井善幸, 安西亜矢子, 柴田一浩, 相澤克則, 佐々木大輔, 吉野正康, 原亜矢子, 福田史郎, 香川育子, 大里直樹, 今野英明, 足立淳, 近藤伸二, 斎藤輪太郎, 岸本直己, 佐藤浩二, 菊池尚志, 林崎良英

    第24回日本分子生物学会年会要旨  2001 

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  • ヒト遺伝子発現制御のインシュレータに関わる DNA結合タンパク質の解析と応用

    大里直樹

    第79回バイオ情報学研究会  2024.9 

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  • イネ完全長cDNAの全長配列決定候補クローンの選択

    大里直樹, 伊藤昌可, 今野英明, カルニンチ ピエロ, 早津徳人, 白木利幸, 広實朋子, 品川朗, 荒川貴博, 石井善幸, 原亜矢子, 福田史朗, 佐々木大輔, 吉野正康, 安西亜矢子, 柴田一浩, 相澤克則, 近藤伸二, 足立淳, 斎藤輪太郎, 太田由己, 河合純, 林崎良英

    第24回日本分子生物学会年会要旨  2001 

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  • ヒト遺伝子発現制御のインシュレータ機能に関わる転写因子の網羅的探索と発見

    大里直樹

    日本遺伝学会第96回大会  2024.9 

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  • Clustering of Full-Length cDNA Clones Based on Both End Sequences International conference

    Naoki Osato, Hideaki Konno, Masayoshi Ito, Shinji Kondo, Jun Kawai, Kazuhiro Shibata, Akira Shinagawa, Jun Adachi, Shiro Fukuda, Yoshimi Ota, Yoshihide Hayashizaki

    Genome Informatics  2000 

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    Venue:Japan  

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  • Systematic discovery of directional regulatory motifs associated with human insulator sites

    Naoki Osato

    Intelligent Systems for Molecular Biology (ISMB)  2024.7 

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  • Natural Antisense Transcripts in Mice

    清澤秀孔, 山中到, 大里直樹, 林崎良英, 阿部訓也

    第25回日本分子生物学会年会要旨  2002 

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  • マウスmRNA配列からの転写因子の同定と解析

    大里直樹, 外丸泰浩, 鈴木正則, 河合純, 林崎良英

    第25回日本分子生物学会年会要旨  2002 

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  • 理研マウス完全長cDNAの全長シーケンス

    荒川貴博, 河合純, カルニンチ ピエロ, 早津徳人, 白木利幸, 岸川(広實)朋子, 伊藤昌可, 石井善幸, 安西亜矢子, 柴田一浩, 相澤克則, 佐々木大輔, 原亜矢子, 香川育子, 福田史郎, 芋谷弘一, 宮崎愛, 橋詰航, 今野英明, 足立淳, 近藤伸二, 大里直樹, 品川朗, 村松正實, 鈴木治和, 岡崎康司, 林崎良英

    第25回日本分子生物学会年会要旨  2002 

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  • イネ(Oryza sativa)完全長cDNAデータ解析-Arabidopsisとイネでの転写因子の比較解析-

    佐藤浩二, 大岡久子, 山田仁美, 田崎公久, 李貞淑, 鈴木宏史, 大里直樹, 大友泰裕, 村上和雄, 松原謙一, 河合純, Carninci P, 林崎良英, 菊池尚志

    第26回日本分子生物学会年会要旨  2003 

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  • イネ完全長cDNAデータを用いたNACファミリーの比較解析

    大岡久子, 佐藤浩二, 永田俊文, 大友泰裕, 松原謙一, 村上和雄, 大里直樹, 河合純, カルニンチ ピエロ, 林崎良英, 鈴木宏史, 小島恵一, 高原美規, 菊地尚志, 山元皓二

    第103回日本育種学会年会要旨  2003 

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  • イネ完全長 cDNA データを用いた転写因子の比較解析(2)

    大岡久子, 永田俊文, 佐藤浩二, 大友泰裕, 松原謙一, 村上和雄, 大里直樹, 河合純, カルニンチピエロ, 林崎良英, 鈴木宏史, 小島恵一, 高原美規, 山元晧二, 菊池尚志

    第102回日本育種学会要旨  2002 

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  • イネの遺伝子と 3'-UTR の多様性との関係

    佐藤浩二, 小島恵一, 大根田英祐, 矢作渡, 鈴木宏史, 大里直樹, 河合純, カルニンチピエロ, 林崎良英, 大友泰裕, 村上和雄, 松原謙一, 山下智也, 東憲児, 鹿島剛輝, 鷲尾尊規, 冨田勝, 菊池尚志

    第102回日本育種学会要旨  2002 

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  • イネの完全長 cDNA における 5'と 3'領域の多型

    佐藤浩二, 小島恵一, 大根田英祐, 矢作渡, 鈴木宏史, 並木高洋, 大里直樹, 河合純, カルニンチピエロ, 林崎良英, 大友泰裕, 村上和雄, 松原謙一, 山下智也, 東憲児, 鹿島剛輝, 鷲尾尊規, 冨田勝, 菊池尚志

    第101回日本育種学会要旨  2002 

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  • Detection and analysis of transcription factors in mouse full-length cDNAs International conference

    Naoki Osato, Yasuhiro Tomaru, Masanori Suzuki, Jun Kawai, Yoshihide Hayashizaki

    The second Cold Spring Harbor Laboratory/Wellcome Trust conference on Genome Informatics  2002 

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    Venue:United Kingdom  

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  • ヒト及びマウスのOverlapping transcriptsの発現制御における役割 Invited

    大里直樹, 池尾一穂, 五條堀孝

    新しいRNA/RNPを見つける会in鶴岡  2005 

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    Venue:慶應義塾大学・先端生命科学研究所  

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  • アンチセンスmRNA候補遺伝子の生物種間の比較解析

    大里直樹, 池尾一穂, 五條堀孝

    第27回日本分子生物学会年会要旨  2004 

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  • 中規模リアルタイムRT-PCRシステムによる転写制御因子群の発現プロファイリング

    奥西理絵, 鈴木治和, 橋詰航, 片山慎太郎, 二宮紀子, 大里直樹, 佐藤健二郎, 中村真理, 飯田樹里, 金森睦, 林崎良英

    第27回日本分子生物学会年会要旨  2004 

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  • イネ完全長 cDNA 情報とシロイヌナズナの予測遺伝子情報を用いた転写因子ファミリーの構造解析

    大岡久子, 佐藤浩二, 永田俊文, 大友泰裕, 松原謙一, 村上和雄, 大里直樹, 河合純, カルニンチピエロ, 林崎良英, 鈴木宏史, 小島恵一, 高原美規, 菊池尚志, 山元皓二

    第215回日本作物学会年会要旨  2003 

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  • 遺伝子発現に影響を及ぼすヒトOverlapping transcriptsの探索

    大里直樹, 五條堀孝

    第79回日本遺伝学会年会要旨  2007 

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  • 完全長cDNA配列を用いたCis sense-antisense mRNAの探索とその発現解析 Invited

    大里直樹

    産業技術総合研究所研究紹介セミナー  2007 

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    Venue:産業技術総合研究所  

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  • ヒトとマウスの比較解析から見たCis sense-antisense mRNAsの発現制御機構とその進化的描像

    大里直樹, 鈴木善幸, 池尾一穂, 五條堀孝

    日本進化学会2006年大会要旨  2006 

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  • Possible regulatory roles of human and mouse overlapping transcripts in gene expression International conference

    Naoki Osato, Ikeo Kazuho, Takashi Gojobori

    Evolutionary Genomics  2005 

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    Venue:Italy  

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  • ヒトOverlapping transcriptsの発現制御における役割

    大里直樹, 池尾一穂, 五條堀孝

    第28回日本分子生物学会年会要旨  2005 

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  • ヒト及びマウスのOverlapping transcriptsの発現制御における役割(2)

    大里直樹, 池尾一穂, 五條堀孝

    第77回日本遺伝学会年会要旨  2005 

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  • アンチセンスmRNAとDNAモチーフ配列のゲノム配列からの探索 Invited

    大里直樹

    国立遺伝学研究所研究会「集団ゲノミクスを考える:ゲノム非タンパク質コード領域の進化」  2008 

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    Venue:国立遺伝学研究所  

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  • Expression of human cis natural antisense transcripts affected by their overlapping arrangements in the genome International conference

    Naoki Osato, Yoshiyuki Suzuki, Kazuho Ikeo, Takashi Gojobori

    International Mammalian Genome Conference  2007 

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    Venue:Japan  

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  • ヒト及びマウスのOverlapping transcriptsの発現制御における役割

    大里 直樹, 鈴木 善幸, 池尾一穂, 五條堀孝

    CBRC シンポジウム  2007 

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  • Transcriptional interferences in cis natural antisense transcripts of humans and mice

    Naoki Osato, Yoshiyuki Suzuki, Kazuho Ikeo, Takashi Gojobori

    Annual Conference of the Japanese Society for Bioinformatics  2007 

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  • Overrepresented DNA motifs in highly conserved non-protein-coding regions of vertebrate genomes(2) International conference

    Naoki Osato, Martin C. Frith

    The 16th CDB meeting on Cis sequence regulation and its evolution  2008 

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  • 脊椎動物ゲノムのタンパク質非コード領域からのDNAモチーフ配列の探索(2)

    大里直樹, Martin C. Frith

    第80回日本遺伝学会年会要旨  2008 

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  • 脊椎動物ゲノムのタンパク質非コード領域からのDNAモチーフ配列の探索

    大里直樹, Martin C. Frith

    日本進化学会2008年大会要旨  2008 

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  • Overrepresented DNA motifs in highly conserved non-protein-coding regions of vertebrate genomes Invited

    Naoki Osato

    JST BIRD meeting  2008 

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    Venue:国立情報学研究所・国際高等セミナーハウス  

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  • Searches for human DNA motif sequences through comparative genome analyses of vertebrate genomes Invited

    Naoki Osato

    JST BIRD meeting  2008 

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    Venue:東京大学・ヒトゲノム解析センター  

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Awards

  • SIGBIO Excellent Presentation Award

    2024.12   Information Processing Society of Japan, Special Interest Group on Bioinformatics and Genomics (SIGBIO)  

    Naoki Osato

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  • The Journal of Translational Genetics and Genomics (JTGG) Award

    2024.4   Human Genome Meeting (HGM)  

    Naoki Osato

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  • IPSJ Yamashita SIG Research Award

    2018.8   Information Processing Society of Japan   Characteristic of functional enrichment of putative transcriptional target genes and its application

    Naoki Osato

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  • SIGBIO Excellent Presentation Award

    2018.5   Information Processing Society of Japan, Special Interest Group on Bioinformatics and Genomics (SIGBIO)   Characteristics of functional enrichement of putative transcriptional target genes and its application

    Naoki Osato

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Research Projects

  • 深層学習による非コードDNA領域の機能と遺伝子発現制御の解明

    2025.3 - 2026.3

    大川情報通信基金  研究助成 

    大里直樹

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  • 深層学習による遺伝子発現制御ネットワーク解析技術の開発

    2022.11 - 2026.1

    カシオ科学振興財団  研究助成 

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    Authorship:Principal investigator 

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  • エンハンサーに関わるDNA配列と遺伝子発現に影響する転写因子の網羅的な探索

    2021.11 - 2024.11

    住友財団  基礎科学研究助成 

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  • 深層学習による生物実験データ解析法と研究仮説検証法の開発

    2021 - 2022.2

    早稲田大学  早大理工総研ーキオクシア若手奨励研究 

    大里直樹

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  • 遺伝子転写制御のゲノムワイドな予測法の開発

    2020 - 2021.3

    大阪大学 情報科学研究科  スタートアッププログラム 

    大里直樹

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  • 線虫のゲノムワイドな転写制御ネットワーク解析

    2009.4 - 2010.3

    山田科学振興財団  海外長期間派遣援助 

    大里直樹

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    Authorship:Principal investigator  Grant type:Competitive

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  • 統計モデルによるゲノムワイドな遺伝子転写カスケード解析法の開発

    文部科学省  科学研究費補助金 基盤研究(C) 

    大里直樹

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    Authorship:Principal investigator  Grant type:Competitive

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