Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

A limitation of widely used intraoral scanners (IOSs) is their inability to capture finish lines at the subgingival marginal area, as they only extract surface information. Swept-source optical coherence tomography (SS-OCT) captures high-speed, high-resolution cross-sectional images of soft and hard tissues. Integrating this technology can overcome clinical IOS limitations. Therefore, this study was conducted to fabricate crowns from three-dimensional images scanned with SS-OCT as a proof-of-principle for its application in IOSs and to evaluate fit accuracy. TRIOS3 was used for comparison, with both SS-OCT and TRIOS3 scanned three times, and crowns were fabricated using the same digital workflow. Internal gaps were measured using scanning electron microscopy, and marginal fit was evaluated via microscopy. Results showed that TRIOS3 had superior accuracy. SS-OCT can image solely in the occlusal direction, with accuracy decreasing at greater depths, which reduces precision around the margin. Additionally, SS-OCT lacks automatic correction of surface information in computer-aided design (CAD) software. To improve SS-OCT accuracy for abutment tooth measurements, automatic margin correction, improved CAD compatibility, and specialized probes for capturing tooth features are needed.

DOI： 10.1371/journal.pone.0333917

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.prosdent.2025.09.035

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.bjoms.2024.10.231

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

ABSTRACT

Background

Implant‐supported prostheses frequently face both mechanical and biological challenges. Although various techniques and principles are employed to manage excessive loads, occlusal contacts often change within 6 months of placement.

Objective

This review aims to analyse relevant studies to evaluate the changes in occlusal contacts that occur following the placement of superstructures in implant‐supported prostheses.

Methods

The protocol was designed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Protocols (PRISMA‐P) and registered with the International Prospective Register of Systematic Reviews. Studies were included if their outcomes addressed stress distribution, occlusal force, occlusal contact, occlusal scheme or changes in occlusal time. Non‐English articles, case reports, animal experiments, systematic reviews and literature reviews were excluded.

Results

A total of 1867 articles were retrieved through database searches, along with an additional 43 articles identified through manual searches, of which 416 were duplicates. After screening the titles and abstracts, 1367 articles were excluded, and 12 were deemed non‐retrievable. The full texts of the remaining 85 articles were independently reviewed by two authors for eligibility, resulting in the exclusion of 77 articles based on the inclusion criteria. Ultimately, eight articles were included in the review.

Conclusion

Implant‐supported crowns gradually approach or surpass the load of natural teeth over time, as evidenced by increased occlusal force, larger contact areas and longer occlusion durations. These findings highlight the need for more accurate and advanced measurement techniques to better understand and manage the long‐term changes in occlusion associated with implant‐supported crowns.

Trial Registration

PROSPERO: CRD42024527043

DOI： 10.1111/joor.70015

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Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jphotochem.2025.116269

Scopus

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

Abstract

Aim:

We aimed to evaluate the diagnostic performance of the You Only Look Once version 8 (YOLOv8) deep learning model in the automated detection of periodontal bone loss (PBL) on panoramic radiographs and assess its potential as a clinical diagnostic aid.

Materials and Methods:

A total of 500 annotated panoramic radiographs with PBL were retrospectively collected and randomized into training (n = 400), validation (n = 50), and testing (n = 50) datasets. Image annotation was performed using Roboflow and validated by a radiologist and periodontist. YOLOv8 models of five variants (n, s, m, l, and x) were trained using Google Colab. Model performance was evaluated via confusion matrix-derived metrics: accuracy, precision, recall, specificity, F1-score, and average detection time. False cases were also analyzed.

Results:

After training and optimization, YOLOv8-s showed the highest mAP result (83.7 ± 1.74%) compared to other variants. During testing, YOLOv8-s demonstrated the highest balance between speed and performance, achieving an accuracy of 90.27% (CI 95% [88.49, 92.05]), precision of 91.27% (CI 95% [89.25, 93.29]), recall of 94.64% (CI 95% [92.99,96.29]), specificity of 80.94% (CI 95% [76.76,85.12]), and an F1-score of 92.98% (CI 95% [91.22, 94.78]) at a 10% confidence threshold. The average detection time per image was 22.6 ms. The most frequent false positives were healthy teeth, while missed detections were mainly mild cases of PBL.

Conclusion:

The YOLOv8 model effectively detects PBL on panoramic radiographs with high accuracy and speed. It holds significant potential as an assistive tool in clinical diagnosis of periodontitis. Future research should focus on severity classification and multi-center validation to enhance clinical integration.

DOI： 10.4103/jioh.jioh_20_25

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

The aim of this study was to investigate the bactericidal effect and recovery of biocompatibility of contaminated titanium surfaces using a combination treatment involving silver, copper, or iron ion application along with 400 nm purple-LED light irradiation. Additionally, the study sought to develop a functional calcium phosphate (CaP) coating treatment on titanium surfaces following disinfection, to promote re-osseointegration. A purple-LED emitting light at 400 nm was utilized to irradiate Staphylococcus aureus suspensions and biofilms in the presence of various concentrations of silver, copper, and iron solutions for 1 min. The bactericidal effect and electron spin resonance (ESR) spectrum were subsequently evaluated. Additionally, the hydrophilicity of the titanium surface and cell viability of MC3T3-E1 cells after combination treatment with silver ion was evaluated. Furthermore, a titanium surface coating with CaP gene transfection carrier containing plasmid DNA was developed using an electric current. The activity of hard tissue formation was then evaluated both in vitro and in vivo post-treatment. The bactericidal effect of the combination treatment with silver ions was attributed to the generation of hydroxyl radicals, whereas the effects from iron and copper treatments were not radical-mediated. The silver treatment significantly restored the hydrophilicity and cell affinity of the titanium surface. Moreover, CaP coating applied via an electric current (30 µA for 5 min) enhanced hard tissue formation activity on the titanium surface in both in vitro and in vivo settings. The combination treatment utilizing silver ions and purple-LED irradiation significantly enhanced bactericidal effects by generating high levels of hydroxyl radicals. Additionally, coating the titanium surface with functionalized CaP promoted early osseointegration, suggesting a promising strategy for improving implant outcomes.

DOI： 10.1038/s41598-025-96075-7

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Other Link： https://www.nature.com/articles/s41598-025-96075-7

Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.prosdent.2025.01.015

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Jordan University of Science and Technology  

Objectives: This study aimed to evaluate the effectiveness of fully remote practical training for the preparation of removable partial dentures, using the video meeting platform Zoom and the communication app. LINE. Materials and Methods: Remote training was applied for one student using Zoom and LINE at the same time as in-person training for the rest of the class. Consumable and instruments needed were delivered to the student subject to remote training in advance. The student’s work was assessed in front of a web camera, at a pre-determined checkpoint during each step. The actual appliances were then mailed to the instructors and reevaluated. The extent of agreement among the assessors for the video-based and direct evaluations, as well as the extent of agreement between the video-based and direct evaluations were calculated. Results: The introduction of Zoom facilitated mutual communication between the student and the instructors. LINE has proven beneficial for practical training. A fully remote practical training class can be conducted smoothly by assigning a dedicated instructor for remote training. The Κ coefficient for agreement between monitor-based and direct evaluations was 0.704 ± 0.12. The survey results indicated that this practical training style was effective in enhancing knowledge and skills. Conclusions: Fully remote blended learning practical training is feasible using Zoom and LINE; however, the tasks to be conducted must be carefully selected. This study is a case report of a single student; thus, future studies should involve fully remote training of small groups to evaluate its educational effectiveness.

DOI： 10.14525/jjd.v2i1.02

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Authorship：Lead author,　Corresponding author   Language：Japanese  

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：(一社)日本顎顔面補綴学会  

血管柄付き遊離腓骨皮弁による下顎骨再建治療を受けた患者1名の臨床データを用いて、術後のフォローアップCT画像解析による再建下顎骨の骨接合部のリモデリング解析、CTデータベースの有限要素解析による再建下顎骨のメカニカルストレス分布解析、これらの解析をもとにした患者固有の骨リモデリングアルゴリズムの構築とその応用を試みた。下顎右側臼歯部の歯肉扁平上皮癌のため下顎骨区域切除術ならびに血管柄付き遊離腓骨皮弁による下顎骨再建術を受けた66歳男性の治療データを用いて一連の解析を行った。下顎骨再建手術直後にCT撮影を実施し、その後は4、16、28ヵ月後に術後フォローアップとしてCT撮影を実施した。オトガイ部の下顎骨-腓骨の接合部をDS1、1ヶ所の腓骨同士の接合部をDS2、顎関節部に近い下顎骨-腓骨の接合部をDS3と定義した。その結果、特に異種骨(下顎骨-腓骨)間接合であるDS1、DS3において骨形態の経時的変化は顕著であり、各接合部において歪みエネルギー密度分布は経時的に大きく変化していた。構築したアルゴリズムを用いたシミュレーション解析により、下顎骨-腓骨間に適切な骨接合が獲得されることで、咬合力が増大しても固定用チタンプレートの破折リスクは増加しないことが示された。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J00255&link_issn=&doc_id=20240711280002&doc_link_id=%2Ffh6gakug%2F2024%2F004701%2F002%2F0006-0013%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffh6gakug%2F2024%2F004701%2F002%2F0006-0013%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

Mandibular deviation (MD) is a common reconstruction sequela after segmental mandibulectomy. Although proper postoperative rehabilitation is critical for MD management and minimization, the information available is limited. This report describes postoperative rehabilitation with an occlusal splint fabricated using computer-aided design (CAD) and computer-aided manufacturing (CAM) (CAD/CAM-OS) and the results of a threedimensional occlusal analysis using an intraoral scanner after hemimandibulectomy and plate reconstruction. Despite the short follow-up, adherence to postoperative rehabilitation with CAD/CAM-OS for MD correction, even during radiotherapy, was demonstrated by the digital workflow and analysis results.

DOI： 10.11607/ijp.8904

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.reth.2023.11.010

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Language：English   Publishing type：Research paper (scientific journal)  

The removal of subgingival deposits, especially calculus, plays a crucial role in basic periodontal therapy. However, manual detection methods affect accuracy owing to the operator's skill. To avoid this uncertainty, we have developed a calculus detection device named "Sensor probe" and evaluated its ability to detect calculus for future clinical applications. The Sensor probe consisted of a 635 nm-wavelength semiconductor laser and a 0.5 mm-diameter single-mode optical fiber. Initially, the performance of the device was evaluated using clinically obtained extracted teeth with calculus covered with a stainless-steel shielding plate with pinhole. Then, the effect of the optical fiber's end shape on calculus detection performance was analyzed. Lastly, the performance of the Sensor probe was compared to that of a conventional periodontal probe in terms of accuracy, sensitivity, and specificity for calculus detection using calculus-covered extracted teeth. The results indicated that Sensor probe detected dental calculus through the pinhole with a diameter of 300 μm or more when applied from a distance of 100 μm. The results analyzing the effect of the optical fiber's end shape on calculus detection performance showed that cutting the fiber end at an angle of 45° resulted in the most effective calculus detection. This may be because the laser light refracted on the cut surface and concentrated on the fiber side. Moreover, by comparing the performance of this device to a conventional periodontal probe revealed that the Sensor probe showed improved calculus detection accuracy in deeper periodontal pockets. This improvement was particularly significant in the apical third, where detection is typically difficult. In conclusion, a Sensor probe that uses an optical fiber with a 45° angled end may facilitate subgingival calculus detection. In future clinical applications, Sensor probes could lead to more accurate and efficient calculus removal, especially for deeper periodontal pockets.

DOI： 10.1371/journal.pone.0314563

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：東北大学歯学会  

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/27705781.2023.2235738

Web of Science

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Authorship：Last author   Language：English  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Corresponding author   Language：Japanese  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: The masseter muscle has a complicated multipennate internal structure and exhibits functional differentiation when performing various stomatognathic functions. It is important to understand the internal structural changes of the muscle during functioning to elucidate characteristic muscle disorders such as local myalgia. Diffusion tensor imaging (DTI) may be useful for investigating the internal structural features of muscle. OBJECTIVES: To evaluate the features of masseter muscle fibres in human participants using DTI fibre tractography, and to elucidate the structural differences in the masseter muscle between the mandibular rest and open positions. METHODS: Five healthy men (age 31 ± 7 years) underwent DTI and T1-weighted MRI of the right masseter muscle in the mandibular rest and open positions. MR images were used as a reference for muscle layer segmentation (superficial, intermediate, and deep). DTI fibre tractography of the masseter muscle was performed and the orientation of the DTI fibres was analysed in each layer using coordinates based on the Frankfurt horizontal plane. RESULTS: The DTI fibre orientation of the deep layer significantly changed between the mandibular rest and open positions in the frontal plane (p < 0.05, Wilcoxon rank sum test). However, no significant change was found in the superficial and intermediate layers. CONCLUSION: DTI fibre tractography confirmed regional differences in the orientation change of the masseter muscle fibres between different mandibular positions. The results may support the existence of functional partitioning inside the masseter muscle and suggest that DTI may be useful for the evaluation of muscle fibres in multipennate muscles.

DOI： 10.1111/joor.13319

PubMed

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.jbiomech.2022.110968

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.4012/dmj.2021-234

Scopus

PubMed

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

The purpose of this study was to investigate the effect of gas species used for low-temperature atmospheric pressure plasma surface treatment, using various gas species and different treatment times, on zirconia surface state and the bond strength between zirconia and dental resin cement. Three groups of zirconia specimens with different surface treatments were prepared as follows: untreated group, alumina sandblasting treatment group, and plasma treatment group. Nitrogen (N2), carbon dioxide (CO2), oxygen (O2), argon (Ar), and air were employed for plasma irradiation. The bond strength between each zirconia specimen and resin cement was compared using a tension test. The effect of the gas species for plasma irradiation on the zirconia surface was investigated using a contact angle meter, an optical interferometer, an X-ray diffractometer, and X-ray photoelectric spectroscopy. Plasma irradiation increased the wettability and decreased the carbon contamination on the zirconia surface, whereas it did not affect the surface topography and crystalline phase. The bond strength varied depending on the gas species and irradiation time. Plasma treatment with N2 gas significantly increased bond strength compared to the untreated group and showed a high bond strength equivalent to that of the sandblasting treatment group. The removal of carbon contamination from the zirconia surface and an increase in the percentage of Zr-O2 on the zirconia surface by plasma irradiation might increase bond strength.

DOI： 10.3390/ma15020631

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Language：English  

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

The Tohoku University Hospital has been a clinical and research facility for all the related departments of Tohoku University. Medical-dental and interprofessional collaboration has resulted in special treatment teams, made up of members of departments such as the center for head and neck cancer, the center for dysphagia, and the cleft lip and palate center. Those treatment teams held conferences, case study meetings, reading sessions, and in-hospital seminars. The purpose of this study was to evaluate the outcomes of various medical-dental and the interprofessional collaboration at Tohoku University Hospital and training program to equip hospital dentists in higher medical institutions. The attainment targets are the acquisition of basic medical skills and knowledge under the guidance of supervising doctors. As a result, the hospital dentists could acquire their own specialized knowledge and skills certificated by each academic society. The smooth team treatment has been achieved, and the number of cases discussed by cancer boards and center for dysphagia has increased year by year due to the efficiency of their clinical pathways. On the dental care side as well, the wearing rates of maxillofacial prosthetic devices such as maxillofacial prostheses and palatal augmentation prostheses (PAP) have improved, which have contributed to improving patient's stomatognathic function. Tohoku University Hospital has been practicing collaboration between medical and dental professionals and it has produced mutual benefits. Our interprofessional training system based on the medical-dental collaboration could develop professionals who have acquired cross-disciplinary knowledge and skills from experienced doctors.

DOI： 10.1620/tjem.256.225

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Language：Japanese   Publisher：(一社)日本顎顔面補綴学会  

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Language：English   Publishing type：Research paper (international conference proceedings)  

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Language：Japanese   Publisher：医歯薬出版(株)  

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Language：Japanese   Publisher：医歯薬出版(株)  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.prosdent.2021.06.044

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：British Institute of Radiology  

In the last few years, artificial intelligence (AI) research has been rapidly developing and emerging in the field of dental and maxillofacial radiology. Dental radiography, which is commonly used in daily practices, provides an incredibly rich resource for AI development and attracted many researchers to develop its application for various purposes. This study reviewed the applicability of AI for dental radiography from the current studies. Online searches on PubMed and IEEE Xplore databases, up to December 2020, and subsequent manual searches were performed. Then, we categorized the application of AI according to similarity of the following purposes: diagnosis of dental caries, periapical pathologies, and periodontal bone loss; cyst and tumor classification; cephalometric analysis; screening of osteoporosis; tooth recognition and forensic odontology; dental implant system recognition; and image quality enhancement. Current development of AI methodology in each aforementioned application were subsequently discussed. Although most of the reviewed studies demonstrated a great potential of AI application for dental radiography, further development is still needed before implementation in clinical routine due to several challenges and limitations, such as lack of datasets size justification and unstandardized reporting format. Considering the current limitations and challenges, future AI research in dental radiography should follow standardized reporting formats in order to align the research designs and enhance the impact of AI development globally.

DOI： 10.1259/dmfr.20210197

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ijfatigue.2021.106160

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.compbiomed.2020.104173

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Authorship：Lead author   Language：Japanese   Publisher：医歯薬出版(株)  

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Authorship：Lead author   Language：Japanese   Publisher：医歯薬出版(株)  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Quintessence Publishing  

PURPOSE: To evaluate the effect of different procedures for retightening the abutment screw on the screw stability between the abutment and implant. MATERIALS AND METHODS: External hexagon connection (EHC) and internal tri-channel connection (ITC) implants were employed in this study. Each abutment screw was used for the following applications (n = 5 for each group): group 0 = abutment was tightened and retightened with a 10-minute interval; group 1 = abutment was tightened and retightened with a 10-minute interval, then loaded for 500,000 cycles; group 2 = abutment was loaded for 83,000 cycles during tightening and retightening and then loaded for 500,000 cycles; group 3 = abutment was loaded for 167,000 cycles during tightening and retightening and then loaded for 500,000 cycles; and group 4 = abutment was loaded for 250,000 cycles during tightening and retightening and then loaded for 500,000 cycles. Both tightening and retightening torques were set at 35 Ncm, and dynamic oblique loading between 0 N and 200 N was applied on the abutment in all groups. The settlement of the abutments (settling value) after retightening and the abutments' removal torque values (RTVs) after testing were measured. RESULTS: No significant differences in settling values were found for EHC or ITC. There were significant differences in the RTVs on EHC implants, but ITC implants showed no difference in RTV with different prosthetic retightening applications. CONCLUSION: The retightening application affected the joint stability of EHC implants, but did not affect the settlement or joint stability of ITC implants.

DOI： 10.11607/ijp.6863

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Authorship：Corresponding author   Language：English  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

BACKGROUND: While hand and ultrasonic scalers are the primary tools used for the removal of dental calculus in periodontal treatment, many studies have shown that they also damage the enamel surface. We have developed a novel actuator-driven pulsed water jet (ADPJ) system, which has the ability to selectively remove materials depending on their stiffness. Considering the different material properties between teeth and dental calculus, it might be possible to develop the ADPJ to remove dental calculus without damage to the tooth's enamel surface using a suitable jet pressure. Therefore, the aim of this study was to assess the effectiveness of the ADPJ in removing dental calculus, and the surface features of the teeth after its use. METHODS: A total of 93 artificial teeth coated with artificial dental calculus were examined in this study. The weights of 90 teeth were measured before and after the use of ADPJ, which had an applied voltage setting of 150, 200, or 240 V. The three remaining teeth were instrumented with a conventional hand scaler, ultrasonic scaler, or ADPJ (set at 240 V). Damage to the artificial tooth surfaces was evaluated using 5% Evans blue dye under an optical microscope. Furthermore, apatite pellets, which are utilized as experimental substitutes for natural teeth, were assessed after the use of ADPJ and both conventional scalers. RESULTS: The ADPJ significantly reduced the amount of artificial calculus, and the removal rate was dependent on the applied voltage. No damage was observed on the surface of the artificial tooth and apatite pellet following the use of ADPJ, in contrast to the conventional scalers. CONCLUSIONS: The results of this study demonstrate the in vitro effectiveness of ADPJ in the removal of dental calculus, without causing damage to tooth surfaces.

DOI： 10.1186/s12903-020-01190-8

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Other Link： http://link.springer.com/article/10.1186/s12903-020-01190-8/fulltext.html

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

<title>Abstract</title>
<sec>
<title>Background</title>
The impact of the jaw bone condition, such as bone quantity and quality in the implant placement site, affecting the accuracy of implant placement with computer-guided surgery (CGS) remains unclear. Therefore, this study aimed to evaluate the influence of bone condition, i.e., bone density, bone width, and cortical bone thickness at the crestal bone on the accuracy of implant placement with CGS.


</sec>
<sec>
<title>Methods</title>
A total of 47 tissue-level implants from 25 patients placed in the posterior mandibular area were studied. Implant placement position was planned on the simulation software, Simplant® Pro 16, by superimposing preoperative computed tomography images with stereolithography data of diagnostic wax-up on the dental cast. Implant placement surgery was performed using the surgical guide plate to reflect the planned implant position. The post-surgical dental cast was scanned to determine the position of the placed implant. Linear and vertical deviations between planned and placed implants were calculated. Deviations at both platform and apical of the implant were measured in the bucco-lingual and mesio-distal directions. Intra- and inter-observer variabilities were calculated to ensure measurement reliability. Multiple linear regression analysis was employed to investigate the effect of the bone condition, such as density, width, and cortical bone thickness at the implant site area, on the accuracy of implant placement (<italic>α</italic> = 0.05).


</sec>
<sec>
<title>Result</title>
Intra- and inter-observer variabilities of these measurements showed excellent agreement (intra class correlation coefficient ± 0.90). Bone condition significantly influenced the accuracy of implant placement using CGS (<italic>p &lt; 0.05</italic>). Both bone density and width were found to be significant predictors.


</sec>
<sec>
<title>Conclusions</title>
Low bone density and/or narrow bucco-lingual width near the alveolar bone crest in the implant placement site might be a risk factor influencing the accuracy of implant placement with CGS.


</sec>

DOI： 10.1186/s40729-020-00249-z

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Other Link： http://link.springer.com/article/10.1186/s40729-020-00249-z/fulltext.html

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

BACKGROUND: Research on resolving implant fracture is still gaining attention as it can be a serious treatment failure outcome. The implant fracture is likely to occur due to increased stress in implant body associated with peri-implant bone resorption. OBJECTIVE: This study aimed to investigate the relationship between degree of peri-implant bone resorption and stress distribution in implant body by using finite element analysis (FEA). METHODS: The magnitude and direction of loads on implants at the mandibular molar region were measured with 3D piezoelectric force transducers in a patient during maximal voluntary clenching, grinding, and tapping to obtain input for the FEA as the loading condition. Simplified finite element bone models were generated to simulate the six patterns of peri-implant bone resorption progression which the bone levels from implant platform were set at 0, 1, 2, 3, 4, and 5 mm. Three types of implants with different diameters (3.5, 4.0, and 5.0 mm), corresponding abutments and screws were created. FEA using the in vivo measured load was conducted to investigate how peri-implant bone loss affects stress distribution in the implant body. RESULTS: Loading condition affected stress distribution in the implant body. As bone resorption increased, von Mises stress in the implant body became larger, which was marked in smaller diameter implants, and this change was amply demonstrated when the bone resorption increased from 0 to 2 mm. CONCLUSION: The FEA demonstrated that as peri-implant bone loss increased, the magnitude of stress in the implant increased, especially in small diameter implants.

DOI： 10.1111/joor.13097

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/joor.13097

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Authorship：Lead author   Language：Japanese   Publisher：医歯薬出版(株)  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

We developed a calcium phosphate-based paste containing siRNA against TNF-α and investigated its anti-inflammatory and bone-healing effects in vitro and in vivo in a rat periodontitis model. The bioactive spherical CaP/PEI/siRNA/SiO2 nanoparticles had a core diameter of 40-90 nm and a positive charge (+23 mV) that facilitated cellular uptake. The TNF- α gene silencing efficiency of the nanoparticles in J774.2 monocytes, gingival-derived cells, and bone marrow-derived cells was 12 ± 2%, 36 ± 8%, and 35 ± 22%, respectively. CaP/PEI/siRNA/SiO2 nanoparticles cancelled the suppression of alkaline phosphatase (ALP) activity in LPS-stimulated bone marrow-derived cells. In vivo, ALP mRNA was up-regulated, TNF-α mRNA was down-regulated, and the amount of released TNF-α was significantly reduced after topical application of the calcium phosphate-based paste containing siRNA-loaded nanoparticles. The number of TNF-α-positive cells in response to CaP/PEI/siRNA/SiO2 nanoparticle application was lower than that observed in the absence of siRNA. Elevated ALP activity and numerous TRAP-positive cells (osteoclasts) were observed in response to the application of all calcium phosphate pastes. These results demonstrate that local application of a paste consisting of siRNA-loaded calcium phosphate nanoparticles successfully induces TNF-α silencing in vitro and in vivo and removes the suppression of ALP activity stimulated by inflammation. STATEMENT OF SIGNIFICANCE: We developed a calcium phosphate-based paste containing nanoparticles loaded with siRNA against TNF-α. The nanoparticles had a core diameter of 40-90 nm and positive charge (+23 mV). The anti-inflammatory and osteoinductive effects of the paste were investigated in vitro and in vivo in a rat periodontitis model. In vitro, the TNF-α gene silencing efficiency of the nanoparticles in J774.2 monocytes, gingival-derived cells, and bone marrow-derived cells was 12 ± 2%, 36 ± 8%, and 35 ± 22%, respectively. The ALP activity of bone marrow-derived cells was recovered. In vivo, TNF-α mRNA was down-regulated and the amount of released TNF-α was significantly reduced, whereas the ALP mRNA was up-regulated. Elevated ALP activity and TRAP-positive cells were observed by immunohistochemistry.

DOI： 10.1016/j.actbio.2020.01.031

PubMed

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Authorship：Lead author   Language：Japanese  

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Authorship：Lead author   Language：Japanese   Publisher：(公社)日本口腔インプラント学会  

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Language：English   Publishing type：Research paper (scientific journal)  

The human masticatory system has received significant attention in the areas of biomechanics due to its sophisticated co-activation of a group of masticatory muscles which contribute to the fundamental oral functions. However, determination of each muscular force remains fairly challenging in vivo; the conventional data available may be inapplicable to patients who experience major oral interventions such as maxillofacial reconstruction, in which the resultant unsymmetrical anatomical structure invokes a more complex stomatognathic functioning system. Therefore, this study aimed to (1) establish an inverse identification procedure by incorporating the sequential Kriging optimization (SKO) algorithm, coupled with the patient-specific finite element analysis (FEA) in silico and occlusal force measurements at different time points over a course of rehabilitation in vivo; and (2) evaluate muscular functionality for a patient with mandibular reconstruction using a fibula free flap (FFF) procedure. The results from this study proved the hypothesis that the proposed method is of certain statistical advantage of utilizing occlusal force measurements, compared to the traditionally adopted optimality criteria approaches that are basically driven by minimizing the energy consumption of muscle systems engaged. Therefore, it is speculated that mastication may not be optimally controlled, in particular for maxillofacially reconstructed patients. For the abnormal muscular system in the patient with orofacial reconstruction, the study shows that in general, the magnitude of muscle forces fluctuates over the 28-month rehabilitation period regardless of the decreasing trend of the maximum muscular capacity. Such finding implies that the reduction of the masticatory muscle activities on the resection side might lead to non-physiological oral biomechanical responses, which can change the muscular activities for stabilizing the reconstructed mandible.

DOI： 10.1016/j.jbiomech.2019.04.007

PubMed

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DOI： 10.5051/jpis.2018.48.6.360

Scopus

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DOI： 10.11607/ijp.5173

PubMed

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Ltd  

DOI： 10.1016/j.medengphy.2018.03.008

Scopus

PubMed

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Language：Japanese   Publisher：(公社)日本口腔インプラント学会  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

PubMed

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DOI： 10.1002/cnm.2889

Web of Science

PubMed

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Language：Japanese   Publisher：(公社)日本補綴歯科学会  

DOI： 10.2186/ajps.9.291

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J05334&link_issn=&doc_id=20171027260003&doc_link_id=%2Fdv5proso%2F2017%2F000904%2F004%2F0291-0296%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdv5proso%2F2017%2F000904%2F004%2F0291-0296%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jpor.2016.12.010

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Language：Japanese   Publisher：東北大学歯学会  

J-GLOBAL

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DOI： 10.1007/s10237-016-0826-x

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Language：Japanese   Publisher：医歯薬出版(株)  

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DOI： 10.11607/ijp.5033

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PubMed

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DOI： 10.1016/j.jpor.2016.01.008

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DOI： 10.11607/jomi.4554

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DOI： 10.1111/joor.12411

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/ID.0000000000000443

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PubMed

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1177/1758736015576009

PubMed

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DOI： 10.1016/j.compbiomed.2014.08.018

Web of Science

PubMed

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DOI： 10.1007/s10266-012-0077-y

Scopus

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.11607/ijp.3223

Web of Science

PubMed

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DOI： 10.2186/ajps.4.183

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DOI： 10.2186/ajps.4.59

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05334&link_issn=&doc_id=20120131280008&doc_link_id=%2Fdv5proso%2F2012%2F000401%2F010%2F0059-0067%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdv5proso%2F2012%2F000401%2F010%2F0059-0067%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.7144/sgf.18.16

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J02994&link_issn=&doc_id=20111214340003&doc_link_id=%2Fex2gakuk%2F2011%2F001801%2F003%2F0016-0025%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fex2gakuk%2F2011%2F001801%2F003%2F0016-0025%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.2186/ajps.3.389

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05334&link_issn=&doc_id=20111020230013&doc_link_id=%2Fdv5proso%2F2011%2F000304%2F015%2F0389-0392%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdv5proso%2F2011%2F000304%2F015%2F0389-0392%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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DOI： 10.1016/j.jpor.2008.08.006

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Prosthodontic Society  

The aims of this study were to measure the three-dimensional (3-D) loads exerted on the implants supporting an overdenture during function in vivo and to clarify the effect of the number of the implants on the loads. The load-measuring devices were mounted on the implants inserted in the mandible of a 62 aged female subject. Either two or four implants connected with a bar were used for supporting her overdenture. The loads on the implants were expressed three dimensionally as load vectors and were analyzed in the coordinates based on the Frankfort horizontal plane and sagittal plane. The tasks examined were maximum voluntary clenching (MVC) and gum chewing (GC). The total load exerted on the implants with a four-implant supported overdenture (4I-Od) was larger than that with a two-implants supported overdenture (2I-Od) at MVC. The maximum occlusal force on the overdenture showed the same manner (p<0.01). The directions of the loads were posterior and lateral at MVC. The total load exerted on the implants located on the working side, was larger than that on the implants located on the non-working side during GC in the case of 4I-Od. The similar manner was also observed in the 2I-Od. The tensile loads were registered during GC. The functional loads exerted on the individual implants in the case of 4I-Od were smaller than those in the 2I-Od. The loads on the implants during function are thus affected by the number of implants supporting the overdenture.

DOI： 10.2186/prp.7.258

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2009105300

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J-GLOBAL

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DOI： 10.1111/j.1365-2842.2007.01681.x

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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DOI： 10.7144/sgf.19.204

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J02994&link_issn=&doc_id=20130415300028&doc_link_id=%2Fex2gakuk%2F2013%2F001902%2F028%2F0204-0205%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fex2gakuk%2F2013%2F001902%2F028%2F0204-0205%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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J-GLOBAL

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DOI： 10.2186/ajps.4.183

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05334&link_issn=&doc_id=20120517320009&doc_link_id=%2Fdv5proso%2F2012%2F000402%2F011%2F0183-0192%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdv5proso%2F2012%2F000402%2F011%2F0183-0192%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.7144/sgf.18.52

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DOI： 10.7144/sgf.17.166

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J02994&link_issn=&doc_id=20110425280019&doc_link_id=%2Fex2gakuk%2F2011%2F001702%2F019%2F0166-0167%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fex2gakuk%2F2011%2F001702%2F019%2F0166-0167%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.7144/sgf.17.62

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J02994&link_issn=&doc_id=20101229290016&doc_link_id=%2Fex2gakuk%2F2010%2F001701%2F016%2F0062-0063%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fex2gakuk%2F2010%2F001701%2F016%2F0062-0063%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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CiNii Books

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J-GLOBAL

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DOI： 10.2186/ajps.1.130

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DOI： 10.1007/978-4-431-99644-6_36

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DOI： 10.1007/978-4-431-99644-6_92

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DOI： 10.7144/sgf.14.108

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J02994&link_issn=&doc_id=20080516320008&doc_link_id=%2Fex2gakuk%2F2008%2F001402%2F009%2F0108-0109%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fex2gakuk%2F2008%2F001402%2F009%2F0108-0109%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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Language：English   Publishing type：Book review, literature introduction, etc.  

DOI： 10.1016/j.ics.2005.07.004

Scopus

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Language：Japanese   Publisher：日本生体医工学会  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Venue：China 大連  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Symposium, workshop panel (public)  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Oral presentation (keynote)  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Oral presentation (keynote)  

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Award type：Award from international society, conference, symposium, etc.  Country：Japan

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Award type：Award from international society, conference, symposium, etc.  Country：Japan

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Award type：Award from international society, conference, symposium, etc. 

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Award type：Award from international society, conference, symposium, etc.  Country：Japan

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Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

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