Updated on 2026/04/18

写真a

 
HARANO KOJI
 
Organization
Institute of Integrated Research Research Center for Autonomous Systems Materialogy Visiting Professor
Title
Visiting Professor
External link

Degree

  • 博士(理学) ( 2007.3   東京大学 )

Research Interests

  • 自己組織化

  • 電子顕微鏡

  • 超分子化学

  • 結晶成長

  • フラーレン

  • 遺伝子治療

  • 結晶多形

  • 分子配向

  • グラフェン

  • 有機薄膜太陽電池

  • ドラッグデリバリー

  • 有機結晶

  • 分析科学

  • 有機デバイス

  • ナノ材料

Research Areas

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Nanotechnology/Materials / Organic functional materials

  • Nanotechnology/Materials / Nanomaterials

  • Nanotechnology/Materials / Analytical chemistry

  • Nanotechnology/Materials / Functional solid state chemistry

  • Nanotechnology/Materials / Nanometer-scale chemistry

  • Nanotechnology/Materials / Inorganic/coordination chemistry

▼display all

Education

  • The University of Tokyo   Graduate School of Science   Department of Chemistry

    2002.4 - 2007.3

      More details

  • The University of Tokyo   Faculty of Science   Department of Chemistry

    1998.4 - 2002.3

      More details

Research History

  • Institute of Science Tokyo   Outside Lecturer

    2025.9 - 2026.3

      More details

    Country:Japan

    researchmap

  • Kyushu University   Professor

    2025.4

      More details

  • Institute of Science Tokyo   Institute of Integrated Research (IIR) Research Center for Autonomous Systems Materialogy (ASMat)   Visiting Professor

    2024.10

      More details

  • Tohoku University

    2024.4 - 2025.3

      More details

  • Tokyo Institute of Technology   Institute of Innovative Research, Research Center for Autonomous Systems Materialogy   Visiting Professor

    2024.4 - 2024.10

      More details

    Country:Japan

    researchmap

  • Tokyo Institute of Technology   Living Systems Materialogy (LiSM), Research Group International Research Frontiers Initiative (IRFI)   Visiting Professor

    2023.5 - 2024.3

      More details

  • National Institute for Materials Science   Electron Microscopy Group, Center for Basic Research on Materials   Principal Researcher

    2023.4

      More details

  • Tokyo Institute of Technology   Living Systems Materialogy (LiSM), Research Group International Research Frontiers Initiative (IRFI)   Collaborator

    2023.4

      More details

  • National Institute for Materials Science   Electron Microscopy Group, Research Center for Advanced Measurement and Characterization   Principal Researcher

    2022.2 - 2023.4

      More details

  • Saitama University   Outside Lecturer

    2021.4 - 2022.3

      More details

    Country:Japan

    researchmap

  • Ochanomizu University   Outside Lecturer

    2021.1 - 2021.3

      More details

    Country:Japan

    researchmap

  • Ibaraki University   Outside Lecturer

    2019.4 - 2019.9

      More details

    Country:Japan

    researchmap

  • Rikkyo University   Outside Lecturer

    2016.10 - 2017.3

      More details

    Country:Japan

    researchmap

  • The University of Tokyo   Graduate School of Science Department of Chemistry   Project Associate Professor

    2015.4 - 2022.1

      More details

    Country:Japan

    researchmap

  • The University of Tokyo   Division of Project Coordination   Specially Appointed Associate Professor

    2015.4 - 2022.1

      More details

  • The University of Tokyo   Graduate School of Science   Assistant Professor

    2007.7 - 2015.3

      More details

  • Tohoku University   Graduate School of Science

    2007.4 - 2007.6

      More details

▼display all

Professional Memberships

  • THE JAPANESE SOCIETY OF MICROSCOPY

      More details

  • 基礎有機化学会

      More details

  • フラーレン・ナノチューブ・グラフェン学会

      More details

  • JAPAN SOCIETY OF COORDINATION CHEMISTRY

      More details

  • THE CHEMICAL SOCIETY OF JAPAN

      More details

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

      More details

▼display all

Committee Memberships

  • Pacifichem 2025   Corresponding Symposium Organizer, "Cinematic Molecular Science and Nanoscience Explored by Electron Microscopy"  

    2023.6 - 2025.12   

      More details

    Committee type:Other

    researchmap

  • Pacifichem2021   Corresponding Symposium Organizer, "Direct Visualization of Chemical and Self-Assembly Processes with High-resolution Microscopy"  

    2020.12 - 2021.12   

      More details

    Committee type:Academic society

    researchmap

  • The 10th Subway Seminar   Chair Organizer  

    2019.8   

      More details

    Committee type:Other

    researchmap

  • International Symposium on Innovative Molecular Technology 2019   Organizing Committee  

    2019.3   

      More details

    Committee type:Other

    researchmap

  • Assembly of Innovative, Knowledgeable, and Outgoing Chemists (AIKOC-2) Symposium   Chair Organizer  

    2018.8   

      More details

    Committee type:Other

    researchmap

  • Symposium on Frontiers of Molecular Science and Technology   Organizing Committee  

    2016.7   

      More details

    Committee type:Other

    researchmap

  • 日本化学会 有機結晶部会   広報委員  

    2016.4   

      More details

    Committee type:Academic society

    researchmap

  • Launch Symposium of Corporate Sponsored Research Program "Molecular Technology Innovation"   Organizing Committee  

    2016.1   

      More details

    Committee type:Other

    researchmap

▼display all

Papers

  • Emergent in-plane dynamics in two-dimensional porous molecular materials

    Javier López-Cabrelles, Koji Harano, Naruhiko Adachi, Yusuke Yamada, Jack D. Evans, Rie Haruki, Reiji Kumai, Biplab Manna, Ken-ichi Otake, Tomoko Inose, Shuhei Furukawa

    ChemRxiv   2026.4

     More details

  • Folding-Mediated Self-Assembly of Sterically Demanding π-Luminophore Dyads into Nanotubes Exhibiting Multidirectional Exciton Transport Reviewed

    Takumi Aizawa, Hironari Arima, Sota Mihara, Takahiro Ueno, Shotaroh Yoshii, Takuho Saito, Hiroki Itabashi, Sougata Datta, Hiroki Hanayama, Akira Sakamoto, Rintaro Shimada, Sarah E. Rogers, Martin J. Hollamby, Takashi Kajitani, Yoshiki Ishii, Go Watanabe, Koji Harano, Takuma Matsumoto, Nithin Pathoor, Martin Vacha, Hikaru Sotome, Shiki Yagai

    Journal of the American Chemical Society   2026.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.6c00854

    researchmap

  • Efficient Room‐Temperature Methane Oxidation by μ‐Nitrido‐Bridged Iron Phthalocyanine Dimer Deposited on Conductive Carbon Black Reviewed

    Yasuyuki Yamada, Akiko Sakata, Yuka Toyoda, Chaoqi Chen, Satoshi Muratsugu, Yutaka Hitomi, Kin‐ichi Oyama, Akiyoshi Kuzume, Koji Harano, Mizuki Tada, Kentaro Tanaka

    ChemCatChem   18 ( 3 )   e01356   2026.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    ABSTRACT

    Appropriate deposition of metal complex‐based catalysts on solid carriers sometimes results in considerably higher catalytic activity than that of the metal complex alone, due to interactions between the complex and the solid. These catalysts could be a part of single‐molecule catalysts (SMCs) or site‐isolated molecular complex catalysts (SIMCs). Herein, we report a solid‐supported metal complex catalyst for CH 4 oxidation at room temperature. Specifically, μ‐nitrido‐bridged iron phthalocyanine dimer deposited on conductive carbon black can oxidatively activate the chemically stable C─H bond of CH 4 with high efficiency even at 25°C in an aqueous solution containing H 2 O 2 as an oxidant. Its catalytic activity for CH 4 oxidation is much higher than that of the commonly used Fenton reaction with Fe 2+ and H 2 O 2 under the same conditions. Such high catalytic oxidizing activity is attributable to the interaction between the specific surface sites of carbon black and the high‐valent iron‐oxo species of the catalyst molecule.

    DOI: 10.1002/cctc.202501356

    researchmap

    Other Link: https://chemistry-europe.onlinelibrary.wiley.com/doi/full-xml/10.1002/cctc.202501356

  • Role of Second Halogen Atoms of Dihalobenzene in Controlling the Photoluminescence Properties of Single-Walled Carbon Nanotubes by Reductive Arylation Reviewed

    Yutaka Maeda, Atsushi Suwa, Kentaro Kawada, Pei Zhao, Masahiro Ehara, Yasuhiro Suzuki, Yui Iguchi, Yasunari Taki, Yui Konno, Michio Yamada, Hitoshi Kasai, Koji Kimoto, Koji Harano

    ACS Nanoscience Au   6 ( 2 )   270 - 280   2025.12

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsnanoscienceau.5c00152

    researchmap

  • Multidirectionally Controlled Arrangement via Ion‐Pairing Assembly of Amphiphilic Charged π‐Electronic Systems Reviewed

    Yuto Maruyama, Biplab Manna, Koji Harano, Hayato Kanai, Yasuhiro Ishida, Hiromitsu Maeda

    Small   22 ( 3 )   e11729   2025.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Charged π‐electronic systems with hydrophilic substituents form lyotropic chromonic liquid crystals (LCLCs) through charge‐by‐charge assembly driven by i π – i π interactions and hydrophobic effects. In this study, the positions and numbers of triethylene glycol (TEG) chains in amphiphilic porphyrin Au III complexes are tuned to control their assembly modes. In combination with the π‐electronic anion pentacyanocyclopentadienide (PCCp ), 5,15‐TEG‐aryl‐substituted porphyrin Au III complex generates lamello‐columnar (Lam col ) phases via amphiphilic i π – i π interactions and proximal interactions at the unsubstituted sites. In the presence of water, the Lam col phases, with lateral hydrophobic effects, exhibit transitions to nematic sheet (N sheet ) and isotropic sheet (Iso sheet ) phases depending on water content and temperature. The Lam col phases align macroscopically under a magnetic field, and scanning transmission electron microscopy (STEM) reveals monolayer sheet structures as key components of the LCLCs. These findings demonstrate a controllable charge‐by‐charge strategy for designing π‐electronic LCLCs with tunable structural and phase behaviors.

    DOI: 10.1002/smll.202511729

    researchmap

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.202511729

  • Laterally π-Extended Polyhelicenes Reviewed

    Hao Wu, Zijie Qiu, Guanzhao Wen, Antoine Hinaut, Koji Harano, Robert Graf, Deborah Prezzi, Lilian Estaque, Yu-Liang Tsai, Dieter Schollmeyer, Grégory Pieters, Elisa Molinari, Rémy Pawlak, Ernst Meyer, Koji Kimoto, Hai I. Wang, Mischa Bonn, Klaus Müllen, Akimitsu Narita

    Journal of the American Chemical Society   147 ( 47 )   43842 - 43849   2025.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.5c15494

    researchmap

  • Nonnegative matrix factorization incorporating domain specific constraints for four dimensional scanning transmission electron microscopy Reviewed

    Koji Kimoto, Fumihiko Uesugi, Koji Harano, Jun Kikkawa, Ovidiu Cretu, Yuki Shibazaki, Motoki Shiga, Atsushi Togo

    Scientific Reports   15   39143   2025.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-025-23541-7

    researchmap

  • Characterizing the effects of temperature on the thermal vibration properties of individual nanowires Reviewed

    Ovidiu Cretu, Han Zhang, Koji Harano, Koji Kimoto

    Journal of Applied Physics   138 ( 13 )   134301   2025.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AIP Publishing  

    We study the effects of temperature on the properties of thermal vibrations of individual LaB6 single-crystal nanowires inside a transmission electron microscope using a method which combines high spatial resolution, high temporal resolution, and in situ temperature control. We find that the vibrations can be accurately modeled by classical formalisms, despite the small size of the resonator. We observe a vibration frequency decrease with temperature which enables us to measure the temperature coefficient of Young's modulus, finding a value of αE≅−9×10−5K−1 over the 300–700 K temperature range. We additionally introduce a method to precisely measure the vibration amplitude, which agrees well with values predicted by the Boltzmann equipartition theorem over the entire temperature range.

    DOI: 10.1063/5.0288200

    researchmap

  • Synergistic Catalysis of PtRu Oxide Cluster for Arene C–H Bond Activation Reviewed

    Shingo Hasegawa, Shion Nakamura, Koji Harano, Ken Motokura

    Applied Catalysis A: General   708   120531 - 120531   2025.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.apcata.2025.120531

    researchmap

  • Thermally polymerizable phthalocyanine realizes a metal–nitrogen-doped carbon material featuring a defined single-atom catalyst motif with CO2RR activity Reviewed

    Yuki Sano, Daichi Nakajima, Biplab Manna, Koki Chida, Ryojun Toyoda, Shinya Takaishi, Kazuyuki Iwase, Koji Harano, Yuta Nishina, Takeharu Yoshii, Ryota Sakamoto

    Journal of Materials Chemistry A   13 ( 35 )   28887 - 28895   2025.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    Metal–nitrogen-doped carbon materials (MNCs) exhibit good electrocatalytic performance owing to the intrinsic advantages of carbon-based materials and the presence of isolated and stabilized metal atoms coordinated by nitrogen sites.

    DOI: 10.1039/d5ta02720a

    researchmap

  • Programmed Assembly of IrAu12 Nanoclusters into Dimers and Trimers: Electron Microscopy Observation and Spectroscopic Characterization Reviewed

    Yuto Fukumoto, Shinjiro Takano, Yosuke Asami, Haru Hirai, Koji Harano, Tatsuya Tsukuda

    Nano Letters   25 ( 32 )   12248 - 12254   2025.8

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.nanolett.5c02770

    researchmap

  • Unveiling Twist Domains in Monolayer MoS 2 through 4D‐STEM and Unsupervised Machine Learning Reviewed

    Koji Kimoto, Ovidiu Cretu, Koji Harano, Fumihiko Uesugi, Jun Kikkawa, Kohei Aso, Yoshifumi Oshima, Takashi Matsumoto, Yoshiki Sakuma

    Small Methods   9 ( 9 )   e01065   2025.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Dichalcogenides, such as molybdenum disulfide (MoS 2 ), are being studied extensively due to their 2D feature and various material properties. Although crystal structures are critical for applications, conventional atomic structure analyses have a limited field of view. In this study, the crystal domains of monolayer MoS 2 synthesized by metal–organic chemical vapor deposition (MOCVD) are analyzed using 4D scanning transmission electron microscopy (STEM) and unsupervised machine learning. Twist domains (±11°) are identified through the nonnegative matrix factorization (NMF) and hierarchical clustering of numerous (>22k) diffraction patterns from a wide field of view. Preprocessing for detecting noncentrosymmetry effectively visualizes the polarities of distinct MoS 2 domains by highlighting the violation of Friedel's law in diffraction physics. Analyses reveal that the specimen deposited on Al 2 O 3 (0001) at 850 °C consists of domains measuring ≈100 nm in size and featuring many mirror‐twin boundaries. The findings provide valuable insights into optimizing the MOCVD process and elucidating crystal growth mechanisms.

    DOI: 10.1002/smtd.202501065

    researchmap

  • Surface‐Exposed Pd Nanocluster Confined within a Ring‐Shaped Polyoxometalate for Selective Hydrogenation Reviewed

    Rui Xi, Kentaro Yonesato, Takafumi Yatabe, Yoshihiro Koizumi, Soichi Kikkawa, Seiji Yamazoe, Koji Harano, Kazuya Yamaguchi, Kosuke Suzuki

    Advanced Science   12 ( 38 )   e09418   2025.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Developing efficient catalysts for selective hydrogenation of molecules bearing multiple reducible functional groups remains a major challenge. Palladium (Pd) nanoclusters are promising candidates owing to their strong H 2 activation ability, broad substrate compatibility, and unique surface properties. However, the controlled synthesis of small Pd nanoclusters with accessible, coordinatively unsaturated active sites remains difficult as they are prone to aggregation. In this study, a strategy is presented to fabricate surface‐exposed Pd nanoclusters confined within a ring‐shaped polyoxometalate (POM) via a mild solid‐state reduction process (1 atm H 2 , ≈25 °C). The resulting Pd nanocluster exhibits exceptional chemoselectivity in the hydrogenation of multifunctional substrates by preferentially adsorbing C═C and C≡C bonds on its discrete, exposed Pd surface with a well‐defined coordination environment. Importantly, the rigid POM framework considerably stabilizes Pd nanocluster, enabling excellent reusability over multiple catalytic cycles. This study demonstrates a molecular templating approach for constructing robust and chemoselective metal nanocluster catalysts, offering new opportunities in the design of hydrogenation systems.

    DOI: 10.1002/advs.202509418

    researchmap

    Other Link: https://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202509418

  • Tetracene Inclusion in Boron Nitride Nanotubes for Photoluminescence Property Modulation Based on Aggregated State Control in Their Nanocavity Reviewed

    Hayato Saeki, Takumi Ehara, Kiyoshi Miyata, Toshikazu Ono, Satoru Emoto, Hiroki Ago, Aki Masaoka, Yoichi Sasaki, Koji Harano, Koji Kimoto, Tsuyohiko Fujigaya, Tomohiro Shiraki

    The Journal of Physical Chemistry Letters   16 ( 30 )   7738 - 7743   2025.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.jpclett.5c01618

    researchmap

  • Accessing a Hidden Pathway to Supramolecular Toroid through Vibrational Strong Coupling Reviewed

    Shunsuke Imai, Takumi Hamada, Misa Nozaki, Takatoshi Fujita, Mariko Takahashi, Yasuhiko Fujita, Koji Harano, Hiroshi Uji-i, Atsuro Takai, Kenji Hirai

    Journal of the American Chemical Society   147 ( 27 )   23528 - 23535   2025.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.5c02960

    researchmap

  • Inside Back Cover: First Encapsulation of Organometallic Single‐Molecule Magnet into Single‐Walled Carbon Nanotubes (Angew. Chem. 22/2025)

    Haitao Zhang, Ryo Nakanishi, Takefumi Yoshida, Masahiko Nishijima, Koji Harano, Yoji Horii, Masahiro Yamashita

    Angewandte Chemie   137 ( 22 )   2025.5

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/ange.202510024

    researchmap

  • Macroscopic Structural Transition of Nickel Dithiolate Capsule with Uniaxial Magnetic Anisotropy in Water Reviewed

    Tomoko Fujino, Mafumi Hishida, Masatoshi Ito, Toshikazu Nakamura, Mizue Asada, Naoya Kurahashi, Hisao Kiuchi, Yoshihisa Harada, Koji Harano, Rie Makiura, Kanokwan Jumtee Takeno, So Yokomori, Hiroshi Oike, Hatsumi Mori

    Advanced Science   12 ( 29 )   2504967   2025.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Meeting the Internet of Things (IoT) demand for flexible organic spintronics requires dynamically flexible, “soft” organic magnetic materials. These materials should be capable of reordering their macroscopic assemblies in response to external stimuli. Unlike conventional rigid, “hard” crystalline organic paramagnets, that are typically composed of open‐shell π‐ or d/π‐conjugated planar molecules and rely on intermolecular interactions in the ordered, assembled structures, soft paramagnets necessitate a delicate balance between long‐range structural order (essential for controlling magnetic properties) and dynamic flexibility a challenge previously unmet for open‐shell planar molecules. In this study, an amphiphilic d/π‐conjugated nickel dithiolate radical anion salt is presented that self‐assembles into ordered membranes, forming capsule‐like macrostructures with exceptional stability in aqueous environments. This design achieves the desired balance. These assemblies exhibit uniaxial magnetic anisotropy driven by significant spin–spin interactions and undergo temperature‐dependent macroscopic structural transitions representing, to the knowledge, the first observation of such behavior for assemblies of open‐shell planar molecules. This well‐defined, single‐molecular‐weight system provides critical structural and mechanism insights for soft matter design and a versatile platform for spintronic applications. The findings advance the development of flexible, tunable molecular soft paramagnets, expanding their potential for innovative applications in flexible devices and beyond.

    DOI: 10.1002/advs.202504967

    researchmap

    Other Link: https://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202504967

  • First Encapsulation of Organometallic Single‐Molecule Magnet into Single‐Walled Carbon Nanotubes Reviewed

    Haitao Zhang, Ryo Nakanishi, Takefumi Yoshida, Masahiko Nishijima, Koji Harano, Yoji Horii, Masahiro Yamashita

    Angewandte Chemie International Edition   64 ( 22 )   e202503979   2025.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    An air‐sensitive DyCp 3 (Cp  = cyclopentadienyl) single‐molecule magnet (SMM) complex ( 1 ) is encapsulated into single‐walled carbon nanotubes (SWCNTs) to construct hybrid materials that are resistant to moisture and oxygen. The hybrid materials with independent slow‐magnetic‐relaxing centers are expected to become a key component of the next generation of information process devices based on spintronics. The resilience to moisture and oxygen further broadens its manufacturing methods and application scenarios. Furthermore, upon encapsulation into SWCNTs, DyCp 3 exhibited clear ac frequency dependence in the ac magnetic susceptibility at a zero‐dc field. This indicates that the guest molecule's slow magnetic relaxation properties are preserved, which is crucial and necessary to realize SMMs‐based quantum information processing, by allowing a sufficient time window for quantum gate operations. This result exemplifies that encapsulation of air‐sensitive organometallic SMMs into SWCNTs enhances their chemical stability and their magnetic relaxation time at a zero‐dc magnetic field, which provides a novel method for their further applications.

    DOI: 10.1002/anie.202503979

    researchmap

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.202503979

  • Coalescence of carbon nanotubes while preserving the chiral angles Reviewed

    Akira Takakura, Taishi Nishihara, Koji Harano, Ovidiu Cretu, Takeshi Tanaka, Hiromichi Kataura, Yuhei Miyauchi

    Nature Communications   16 ( 1 )   1093   2025.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Atomically precise coalescence of graphitic nanocarbon molecules is one of the most challenging reactions in sp 2 carbon chemistry. Here, we demonstrate that two carbon nanotubes with the same chiral indices (n, m) are efficiently coalesced into a single (2n, 2 m) nanotube with preserved chiral angles via heat treatment at less than 1000 °C. The (2n, 2 m) nanotubes constitute up to ≈ 20%–40% of the final sample in the most efficient case. Additional optical absorption peaks of the (2n, 2 m) nanotubes emerge, indicating that the reaction occurs over the entire sample. The reaction efficiency strongly depends on the chiral angle, implying that C–C bond cleavage and recombination occurs sequentially. Furthermore, the reaction occurs efficiently even at 600 °C in an atmosphere containing trace amounts of oxygen. These findings offer routes for the structure-selective synthesis of large-diameter nanotubes and modification of the properties of nanotube assemblies via postprocessing.

    DOI: 10.1038/s41467-025-56389-6

    researchmap

    Other Link: https://www.nature.com/articles/s41467-025-56389-6

  • Pd Nanoparticles Decorated by Oxidized Ru Clusters for Efficient C–H/C–H Coupling of Arenes Reviewed

    Shingo Hasegawa, Shunta Tokutake, Koji Harano, Ken Motokura

    ACS Catalysis   15 ( 1 )   487 - 493   2024.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acscatal.4c05551

    researchmap

  • Dendron-mediated control over self-assembly of chlorophyll rosettes into columnar vs. discrete aggregates Invited Reviewed

    Ryo Kudo, Hiroki Hanayama, Balaraman Vedhanarayanan, Hitoshi Tamiaki, Nobuyuki Hara, Sarah E. Rogers, Martin J. Hollamby, Biplab Manna, Koji Harano, Shiki Yagai

    Organic Chemistry Frontiers   11 ( 22 )   6304 - 6310   2024.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    By controlling the π-π stacking of chlorophyll supramolecular rosettes through steric hindrance of alkyl dendrons, it become possible to create chlorophyll tubes and discrete rings that resemble to natural chlorophyll assemblies.

    DOI: 10.1039/d4qo01629g

    researchmap

  • Pentagon‐Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes Reviewed

    Guoping Chen, Miho Isegawa, Taro Koide, Yasuo Yoshida, Koji Harano, Kenji Hayashida, Shusaku Fujita, Kotaro Takeyasu, Katsuhiko Ariga, Junji Nakamura

    Angewandte Chemie International Edition   63 ( 49 )   2024.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    The interaction between electron spin and oxygen molecules in non‐platinum catalysts, particularly carbon catalysts, significantly influences the catalytic performance of the oxygen reduction reaction (ORR). A promising approach to developing high‐performance catalysts involves introducing five‐membered ring structures with spin into graphitic carbons. In this study, we present the successful synthesis of cage‐like cubic carbon catalysts enriched with pentagon structures using pentagon ring‐containing C60 and a NaCl template. The number of pentagons contained in the structure was increased by doping with nitrogen and annealing, and the number of electron spins also increased, thereby improving catalytic activity. The prepared catalyst exhibits remarkable activity in ORR under acidic electrolytes. Furthermore, we elucidate the correlation between the pentagon structure, the number of spin, and catalytic activity, demonstrating that enhanced activity is contingent upon the presence of spin. Density functional theory (DFT) calculations support the role of spin in improving activity. The concept of spin and the introduction of pentagon structures provide new design principles for carbon catalysts.

    DOI: 10.1002/anie.202410747

    researchmap

  • Reduction‐Induced Self‐Propelled Oscillatory Motion of Perylenediimides on Water Reviewed

    Lara Rae Holstein, Nobuhiko J. Suematsu, Masayuki Takeuchi, Koji Harano, Taisuke Banno, Atsuro Takai

    Angewandte Chemie International Edition   63 ( 46 )   e202410671   2024.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    The emergence of macroscopic self‐propelled oscillatory motion based on molecular design has attracted continual attention in relation to autonomous systems in living organisms. Herein, a series of perylenediimides (PDIs) with various imide side chains was prepared to explore the impact of molecular design and alignment on the self‐propelled motion at the air‐water interface. When placed on an aqueous solution containing a reductant, a solid disk of neutral PDI was reduced to form the water‐soluble, surface‐active PDI dianion species, which induces a surface tension gradient in the vicinity of the disk for self‐propelled motion. We found that centimeter‐scale oscillatory motion could be elicited by controlling the supply rate of PDI dianion species through the reductant concentration and the structure of the imide side chains. Furthermore, we found that the onset and speed of the self‐propelled motion could be changed by the crystallinity of PDI at the water surface. This design principle using π‐conjugated molecules and their self‐assemblies could advance self‐propelled, non‐equilibrium systems powered by chemical energy.

    DOI: 10.1002/anie.202410671

    researchmap

  • Blue Shift of Localized Surface Plasmon Resonance of Gold Ultrathin Nanorod by Forming a Single Atomic Silver Shell via Antigalvanic Process Reviewed

    Subarna Maity, Toshiki Komagata, Shinjiro Takano, Shinya Masuda, Jun Kikkawa, Koji Kimoto, Koji Harano, Tatsuya Tsukuda

    Nano Letters   24 ( 42 )   13206 - 13212   2024.9

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.nanolett.4c03159

    researchmap

  • Ion‐Pairing Chromonic Liquid Crystals via Alternately Stacked Assembly of Amphiphilic Charged π‐Electronic Systems Reviewed

    Yuto Maruyama, Koji Harano, Hayato Kanai, Yasuhiro Ishida, Hiroki Tanaka, Shinya Sugiura, Hiromitsu Maeda

    Angewandte Chemie International Edition   2024.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>In this study, a new assembly strategy for lyotropic chromonic liquid crystals (LCLCs) is proposed using iπ–iπ interactions, mainly comprising electrostatic and dispersion forces, between charged π‐electronic systems to form stacking structures supported by the hydration of triethylene glycol (TEG) units.  Meso‐TEG‐aryl‐substituted porphyrin AuIII complex, an amphiphilic π‐electronic cation, showed diverse states and assembly modes in ion pairs depending on the coexisting counteranions.  The PCCp– ion pair formed a hexagonal columnar (Colh) LC phase based on a charge‐by‐charge assembly, suggesting the formation of an ordered arrangement of charged p‐electronic systems through iπ–iπ interactions, with reduced interactions between the TEG chains.  Furthermore, in the presence of water, LCLC behaviors in the Colh and nematic columnar phases according to the amount of water were observed for the PCCp– ion pair via iπ–iπ interactions.  Magnetic‐field‐induced orientation of the charge‐by‐charge columnar structures upon dehydration was observed.  Furthermore, single‐stranded charge‐by‐charge columnar structures, as components of the LCLCs, were observed using transmission electron microscopy (TEM).</jats:p>

    DOI: 10.1002/anie.202415135

    researchmap

  • RhRu Bimetallic Oxide Cluster Catalysts for Cross-Dehydrogenative Coupling of Arenes and Carboxylic Acids Reviewed

    Shingo Hasegawa, Koji Harano, Ken Motokura

    Journal of the American Chemical Society   146 ( 28 )   19059 - 19069   2024.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.4c03467

    researchmap

  • Ambipolar charge-trapping in self-assembled nanostructures of a supramolecular miktoarm star-shaped copolymer with a zinc phthalocyanine core Reviewed

    Xinhao Zhong, Debdatta Panigrahi, Ryoma Hayakawa, Yutaka Wakayama, Koji Harano, Masayuki Takeuchi, Junko Aimi

    Journal of Materials Chemistry C   12 ( 26 )   9642 - 9651   2024.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    Supramolecular miktoarm star-shaped copolymers with a zinc phthalocyanine core exhibit phase-separated nanostructures that enhance ambipolar charge-trapping capabilities in the organic field-effect transistor memory devices.

    DOI: 10.1039/d4tc01265h

    researchmap

  • Structures, fundamental properties, and potential applications of low-dimensional C 60 polymers and other nanocarbons: a review Invited Reviewed

    Jun Onoe, Yusuke Noda, Qian Wang, Koji Harano, Masato Nakaya, Tomonobu Nakayama

    Science and Technology of Advanced Materials   25 ( 1 )   2346068   2024.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Informa UK Limited  

    DOI: 10.1080/14686996.2024.2346068

    researchmap

  • Cinematographic study of stochastic chemical events at atomic resolution Invited Reviewed

    Koji Harano, Takayuki Nakamuro, Eiichi Nakamura

    Microscopy   2024.4

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jmicro/dfad052

    researchmap

  • Grinding‐Induced Water Solubility Exhibited by Mechanochromic Luminescent Supramolecular Fibers Reviewed

    Qiming Liu, Tianyue Zhang, Yuka Ikemoto, Yudai Shinozaki, Go Watanabe, Yuta Hori, Yasuteru Shigeta, Takemi Midorikawa, Koji Harano, Yoshimitsu Sagara

    Small   20 ( 33 )   2400063   2024.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Most mechanochromic luminescent compounds are crystalline and highly hydrophobic; however, mechanochromic luminescent molecular assemblies comprising amphiphilic molecules have rarely been explored. This study investigated mechanochromic luminescent supramolecular fibers composed of dumbbell‐shaped 9,10‐bis(phenylethynyl)anthracene‐based amphiphiles without any tetraethylene glycol (TEG) substituents or with two TEG substituents. Both amphiphiles formed water‐insoluble supramolecular fibers via linear hydrogen bond formation. Both compounds acquired water solubility when solid samples composed of supramolecular fibers are ground. Grinding induces the conversion of 1D supramolecular fibers into micellar assemblies where fluorophores can form excimers, thereby resulting in a large redshift in the fluorescence spectra. Excimer emission from the ground amphiphile without TEG chains is retained after dissolution in water. The micelles are stable in water because hydrophilic dendrons surround the hydrophobic luminophores. By contrast, when water is added to a ground amphiphile having TEG substituents, fragmented supramolecular fibers with the same molecular arrangement as the initial supramolecular fibers are observed, because fragmented fibers are thermodynamically preferable to micelles as the hydrophobic arrays of fluorophores are covered with hydrophilic TEG chains. This leads to the recovery of the initial fluorescent properties for the latter amphiphile. These supramolecular fibers can be used as practical mechanosensors to detect forces at the mesoscale.

    DOI: 10.1002/smll.202400063

    researchmap

  • Diphosphine‐Protected IrAu12 Superatom with Open Site(s): Synthesis and Programmed Stepwise Assembly Reviewed

    Yuto Fukumoto, Tsubasa Omoda, Haru Hirai, Shinjiro Takano, Koji Harano, Tatsuya Tsukuda

    Angewandte Chemie International Edition   63 ( 18 )   e202402025   2024.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    One or two phenylacetylide (PA) ligand(s) were successfully removed from the IrAu12 superatomic core of [IrAu12(dppe)5(PA)2]+ (dppe=1,2‐bis(diphenylphosphino)ethane) by reaction with controlled amounts of tetrafluoroboric acid. Optical and nuclear magnetic resonance spectroscopies and density functional theory calculations revealed the formation of open Au site(s) on the IrAu12 core of [IrAu12(dppe)5(PA)1]2+ and [IrAu12(dppe)5]3+ with the remaining structure intact. Isocyanide was efficiently trapped at the open electrophilic site on [IrAu12(dppe)5(PA)1]2+, whereas a dimer or trimer of the IrAu12 superatoms was formed using diisocyanide as a linker. These results open the door to designed assembly of chemically modified metal superatoms.

    DOI: 10.1002/anie.202402025

    researchmap

  • Unsupervised machine learning combined with 4D scanning transmission electron microscopy for bimodal nanostructural analysis Reviewed

    Koji Kimoto, Jun Kikkawa, Koji Harano, Ovidiu Cretu, Yuki Shibazaki, Fumihiko Uesugi

    Scientific Reports   14   2901   2024.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-024-53289-5

    researchmap

  • Fast electron damage mechanism of epoxy resin studied by electron energy loss spectroscopy and electron diffraction Reviewed

    Jun Kikkawa, Aoi Nii, Yoshiaki Sakaniwa, Naochika Kon, Marina Sakamaki, Touyou Ohashi, Nobuyasu Nita, Koji Harano, Koji Kimoto

    The Journal of Chemical Physics   159 ( 17 )   174708   2023.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AIP Publishing  

    The damage mechanism and exposure tolerance of epoxy resins to fast electrons remain unclear. We quantitatively investigated the effects of electron irradiation on a common epoxy resin by dose-dependent electron energy loss spectroscopy. The results show that sp3 states of nitrogen, oxygen, and their adjacent carbon atoms were converted to sp2 states, forming imine (C=N) and carbonyl (C=O) as the total electron dose increased. The sp3 to sp2 conversion mechanism was proposed. The epoxy resin was very sensitive to fast electrons and the original electronic states were maintained up to a total dose of ∼103e− nm−2 at a low temperature of 103 K. Dose-dependent electron diffraction revealed that the intra- and intermolecular geometries changed below and around the total dose of ∼103e− nm−2.

    DOI: 10.1063/5.0177019

    researchmap

  • Supramolecular Polymer Polymorphism: Spontaneous Helix–Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes Reviewed

    Chie Otsuka, Sho Takahashi, Atsushi Isobe, Takuho Saito, Takumi Aizawa, Ryoma Tsuchida, Shuhei Yamashita, Koji Harano, Hiroki Hanayama, Nobutaka Shimizu, Hideaki Takagi, Rie Haruki, Luzhi Liu, Martin J. Hollamby, Takahiro Ohkubo, Shiki Yagai

    Journal of the American Chemical Society   2023.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.3c07556

    researchmap

  • Au13 Superatom Bearing Two Terpyridines at Coaxial Positions: Photoluminescence Quenching via Complexation with 3d Metal Ions Reviewed

    Naoki Kito, Shinjiro Takano, Shinya Masuda, Koji Harano, Tatsuya Tsukuda

    Bulletin of the Chemical Society of Japan   2023.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/bcsj.20230148

    researchmap

  • Time-resolved imaging and analysis of the electron beam-induced formation of an open-cage metallo-azafullerene Reviewed

    Helen Hoelzel, Sol Lee, Konstantin Yu. Amsharov, Norbert Jux, Koji Harano, Eiichi Nakamura, Dominik Lungerich

    Nature Chemistry   15 ( 10 )   1444 - 1451   2023.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41557-023-01261-7

    researchmap

    Other Link: https://www.nature.com/articles/s41557-023-01261-7

  • Saturated Linkers in Two-Dimensional Covalent Organic Frameworks Boost Their Luminescence Reviewed

    Meijia Yang, Hiroki Hanayama, Long Fang, Matthew A. Addicoat, Yunyu Guo, Robert Graf, Koji Harano, Jun Kikkawa, Enquan Jin, Akimitsu Narita, Klaus Müllen

    Journal of the American Chemical Society   145 ( 26 )   14417 - 14426   2023.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.3c03614

    researchmap

  • Wavy Graphene-Like Network Forming during Pyrolysis of Polyacrylonitrile into Carbon Fiber Reviewed

    Toru Ishikawa, Fumihiko Tanaka, Kosuke Kurushima, Akira Yasuhara, Ryusuke Sagawa, Tatsuya Fujita, Ryohei Yonesaki, Katsuhiko Iseki, Takayuki Nakamuro, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   145 ( 22 )   12244 - 12254   2023.5

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.3c02504

    researchmap

  • Defect Photoluminescence from Alkylated Boron Nitride Nanotubes Reviewed

    Tomohiro Shiraki, Rioe Saito, Hayato Saeki, Naoki Tanaka, Koji Harano, Tsuyohiko Fujigaya

    Chemistry Letters   52 ( 1 )   44 - 47   2023.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/cl.220467

    researchmap

  • Cinematographic imaging and analysis of the electron beam-induced formation of an endohedral metalloporphyrin-fullerene hybrid

    Helen Hölzel, Sol Lee, Konstantin Amsharov, Norbert Jux, Koji Harano, Eiichi Nakamura, Dominik Lungerich

    Research Square   2022.10

     More details

    Publisher:Research Square Platform LLC  

    Abstract

    The bottom-up synthesis of strained hollow cage structures, such as fullerenes, using traditional thermal or photochemical methods remains one of the most challenging tasks in organic chemistry. Here, we demonstrate the synthetic use of an electron beam by in-depth single-molecule atomic resolution time-resolved transmission electron microscopy studies to induce the formation of an elusive doubly-holed fullerene-porphyrin cage structure from a well-defined benzoporphyrin precursor deposited on graphene. Through real-time imaging, we analyze the hybrid's peculiar ability to host up to two Pb atoms and subsequently gain insights into the dynamics of the Pb–Pb binding motif in this exotic metallo-organic cage structure. Through density functional theory calculations and image simulations, we conclude that the much slower secondary electrons, which accumulate in the irradiated area's periphery, can also initiate chemical reactions. Consequently, designing advanced carbon nanostructures by e-beam lithography will depend on the understanding and limitations of molecular radiation chemistry.

    DOI: 10.21203/rs.3.rs-1929472/v1

    researchmap

    Other Link: https://www.researchsquare.com/article/rs-1929472/v1.html

  • Synergistically Activated Pd Atom in Polymer-Stabilized Au23Pd1 Cluster Reviewed

    Shingo Hasegawa, Shinya Masuda, Shinjiro Takano, Koji Harano, Jun Kikkawa, Tatsuya Tsukuda

    ACS Nano   16 ( 10 )   16932 - 16940   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsnano.2c06996

    researchmap

  • Dynamic Molecular Science Explored with Cinematographic Molecular Imaging Invited Reviewed

    Koji Harano, Takayuki Nakamuro, Eiichi Nakamura

    Microscopy   57 ( 2 )   59 - 64   2022.9

     More details

    Authorship:Lead author, Corresponding author   Language:Japanese  

    DOI: 10.11410/kenbikyo.57.2_59

    J-GLOBAL

    researchmap

  • Excited state modulation of C70 dimerization in a carbon nanotube under a variable electron acceleration voltage Reviewed

    Dongxin Liu, Dominik Lungerich, Takayuki Nakamuro, Koji Harano, Eiichi Nakamura

    Micron   160   103316 - 103316   2022.9

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.micron.2022.103316

    researchmap

  • Submillisecond Electron Microscopic Video Imaging for Cinematic Molecular Science Invited

    Koji Harano

    Microscopy and Microanalysis   28 ( S1 )   1924 - 1925   2022.8

     More details

    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cambridge University Press ({CUP})  

    DOI: 10.1017/s1431927622007528

    researchmap

  • Time-Resolved Atomistic Imaging and Statistical Analysis of Daptomycin Oligomers with and without Calcium Ions Reviewed

    Takayuki Nakamuro, Ko Kamei, Keyi Sun, Jeffrey W. Bode, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   144 ( 30 )   13612 - 13622   2022.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.2c03949

    researchmap

  • Time-Resolved Imaging of Stochastic Cascade Reactions over a Submillisecond to Second Time Range at the Angstrom Level Reviewed

    Toshiki Shimizu, Dominik Lungerich, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   144 ( 22 )   9797 - 9805   2022.6

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    Most chemical reactions are cascade reactions in which a series of transient intermediates appear and disappear stochastically over an extended period. The mechanisms of such reactions are challenging to study, even in ultrafast pump-probe experiments. The dimerization of a van der Waals dimer of [60]fullerene producing a short carbon nanotube is a typical cascade reaction and is probably the most frequently studied in carbon materials chemistry. As many as 23 intermediates were predicted by theory, but only the first stable one has been verified experimentally. With the aid of fast electron microscopy, we obtained cinematographic recordings of individual molecules at a maximum frame rate of 1600 frames per second. Using Chambolle total variation algorithm processing and automated cross-correlation image matching analysis, we report on the identification of several metastable intermediates by their shape and size. Although the reaction events occurred stochastically, varying the lifetime of each intermediate accordingly, the average lifetime for each intermediate structure could be obtained from statistical analysis of many cinematographic images for the cascade reaction. Among the shortest-living intermediates, we detected one that lasted for less than 3 ms in three independent cascade reactions. We anticipate that the rapid technological development of microscopy and image processing will soon initiate an era of cinematographic studies of chemical reactions.

    DOI: 10.1021/jacs.2c02297

    researchmap

  • Polymer-Stabilized Au38 Cluster: Atomically Precise Synthesis by Digestive Ripening and Characterization of the Atomic Structure and Oxidation Catalysis Reviewed

    Shingo Hasegawa, Shinya Masuda, Shinjiro Takano, Koji Harano, Tatsuya Tsukuda

    ACS Catalysis   12 ( 11 )   6550 - 6558   2022.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acscatal.2c01355

    researchmap

  • De Novo Synthesis of Free‐Standing Flexible 2D Intercalated Nanofilm Uniform over Tens of cm 2 Reviewed

    Prince Ravat, Hikaru Uchida, Ryosuke Sekine, Ko Kamei, Akihisa Yamamoto, Oleg Konovalov, Motomu Tanaka, Teppei Yamada, Koji Harano, Eiichi Nakamura

    Advanced Materials   34 ( 33 )   2106465 - 2106465   2022.6

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/adma.202106465

    researchmap

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.202106465

  • Ionization and electron excitation of C60 in a carbon nanotube: A variable temperature/voltage transmission electron microscopic study Reviewed

    Dongxin Liu, Satori Kowashi, Takayuki Nakamuro, Dominik Lungerich, Kaoru Yamanouchi, Koji Harano, Eiichi Nakamura

    Proceedings of the National Academy of Sciences   119 ( 15 )   e2200290119   2022.4

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Proceedings of the National Academy of Sciences  

    <jats:title>Significance</jats:title>
    <jats:p>
    The destruction of specimen molecules by an electron beam (e-beam) is either beneficial, as in mass spectrometry capitalizing on ion formation, or deleterious, as in electron microscopy. In the latter application, the e-beam not only produces the specimen image, but also causes information loss upon prolonged irradiation. However, the atomistic mechanism of such loss has been unclear. Performing single-molecule kinetic analysis of C
    <jats:sub>60</jats:sub>
    dimerization in a carbon nanotube (CNT) under variable-temperature/voltage conditions, we identified three reactive species—that is, radical cation, singlet, and triplet excited states—reacting competitively as the voltage and the properties of the CNT were changed. The key enabler was in situ continuous recording of the whole reaction process, suggesting an upcoming new era of “cinematic chemistry.”
    </jats:p>

    DOI: 10.1073/pnas.2200290119

    researchmap

  • Time-resolved Atomistic Imaging and Statistical Analysis of Daptomycin Oligomers with and without Calcium Ion

    Takayuki Nakamuro, Ko Kamei, Keyi Sun, Jeffrey W. Bode, Koji Harano, Eiichi Nakamura

    ChemRxiv   2022.4

     More details

    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    <jats:p>Daptomycin (DP) is effective against multiple drug-resistant Gram-positive pathogens because of its distinct mechanism of action. An accepted mechanism includes Ca2+-triggered aggregation of the DP molecule to form oligomers. DP and its oligomers have so far defied structural analysis at a molecular level, and we studied the process by the combined use of dynamic light scattering in water and atomic-resolution cinematographic imaging of DP molecules captured on a carbon nanotube on which the DP molecule is installed as a fishhook. We found that the DP molecule aggregates weakly into dimers, trimers, and tetramers in water, and strongly in the presence of calcium ions, and that the tetramer is the largest oligomer in a homogeneous aqueous solution. The dimer remains as the major species under a variety of conditions, and we propose a face-to-face stacked structure based on dynamic imaging using millisecond and angstrom resolution transmission electron microscopy. The tetramer is the largest oligomer observed both in the absence and in the presence of a large excess of calcium ions. Taken together with statistical data, the microscopic structural information obtained at a single-molecule level favors a cyclic form of the dimer and the tetramer over a linear or stacked form. Such experimental structural information is new and will serve as a platform for future drug design. The data also illustrate the utility of cinematographic recording of dynamic motions of molecules for the study of self-organization processes.</jats:p>

    DOI: 10.26434/chemrxiv-2022-xdkxs

    researchmap

  • Atomic-number (Z)-correlated atomic sizes for deciphering electron microscopic molecular images Reviewed

    Junfei Xing, Keishi Takeuchi, Ko Kamei, Takayuki Nakamuro, Koji Harano, Eiichi Nakamura

    Proceedings of the National Academy of Sciences   119 ( 14 )   e2114432119   2022.4

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.2114432119

    Web of Science

    researchmap

  • Electron-Impact Promoted Selective [2 + 2 ] Cycloaddition Mediated by Carbon Nanotube. A Variable-Temperature Variable-Voltage Transmission Electron Microscopic Study

    Koji Harano

    arXiv   2021.10

     More details

    An electron beam (e-beam) is a particle beam that transfers its kinetic energy via momentum transfer to materials to cause plasmon excitation, electron-impact ionization, and atom displacement, but it lacks the electric dipole transition mechanism for electron excitation of a 0D material. We report herein e-beam-induced [2 + 2 ] cycloaddition of van der Waals dimers of C60 by the use of 1D carbon nanotubes (CNTs) as a mediator of energy transfer from e-beam to C60. In situ video imaging of individual reaction events with atomic-resolution transmission electron microscopy was the key technology for determination of the pre-exponential factor for the excitation and the activation energy for the ensuing dimerization. We found that the reac-tion in pristine, oxidized, and damaged CNTs effects three pathways of dimerization via a singlet, triplet, and radical cation, respectively. The overall kinetic profile changed, depending on variations in the kinetic energy of the e-beam (between 60 keV and 120 keV), the nature of the CNTs, and the temperature. The singlet and triplet reactions require approximately 10-3 and 10-6 electrons, respectively, for one reaction event to take place, indicating that the efficiency of the energy transfer from e-beam to C60 via CNT is very low because of the lack of effective mechanism to mediate the energy transfer. We see the chemistry reported here is a rare example of "e-beam catalysis", where CNT under electron irradiation accelerates a chemical reaction that otherwise does not occur. The study indicates the necessity to perform "variable-temperature variable-voltage" kinetic studies in order to properly understand the mechanism of chemical events taking place under e-beam irradiation.

    arXiv

    researchmap

  • A Singular Molecule-to-Molecule Transformation on Video: The Bottom-Up Synthesis of Fullerene C60 from Truxene Derivative C60H30 Reviewed

    Dominik Lungerich, Helen Hoelzel, Koji Harano, Norbert Jux, Konstantin Yu. Amsharov, Eiichi Nakamura

    ACS Nano   15 ( 8 )   12804 - 12814   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acsnano.1c02222

    researchmap

  • Atomic-Number (Z)-Correlated Atomic Sizes for Deciphering Electron Microscopic Molecular Images

    Junfei Xing, Keishi Takeuchi, Ko Kamei, Takayuki Nakamuro, Koji Harano, Eiichi Nakamura

    arXiv   119 ( 14 )   2021.7

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.48550/arXiv.2107.01490

    Web of Science

    arXiv

    researchmap

  • New Magic Au24 Cluster Stabilized by PVP: Selective Formation, Atomic Structure, and Oxidation Catalysis Reviewed

    Shingo Hasegawa, Shinjiro Takano, Koji Harano, Tatsuya Tsukuda

    JACS Au   1 ( 5 )   660 - 668   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/jacsau.1c00102

    researchmap

  • Rim Binding of Cyclodextrins in Size-Sensitive Guest Recognition Reviewed

    Hiroki Hanayama, Junya Yamada, Issei Tomotsuka, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   143 ( 15 )   5786 - 5792   2021.4

     More details

    Authorship:Corresponding author   Language:English  

    DOI: 10.1021/jacs.1c00651

    Web of Science

    J-GLOBAL

    researchmap

  • Few-nm-sized, phase-pure Au5Sn intermetallic nanoparticles: synthesis and characterization Reviewed

    Satoshi Osugi, Shinjiro Takano, Shinya Masuda, Koji Harano, Tatsuya Tsukuda

    Dalton Transactions   50 ( 15 )   5177 - 5183   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    <p>Few-nm-sized, phase-pure Au5Sn intermetallic nanoparticles (IMNPs) were synthesized by co-reduction of Au3+ and Sn2+ precursors with the ratio of 6 : 4 in the presence of oleylamine. Optical and catalytic properties of the Au5Sn IMNPs were compared to those of pure Au NPs.</p>

    DOI: 10.1039/D1DT00132A

    researchmap

  • Nano- and Microspheres Containing Inorganic and Biological Nanoparticles: Self-Assembly and Electron Tomographic Analysis Reviewed International journal

    Ryosuke Sekine, Prince Ravat, Haruaki Yanagisawa, Chao Liu, Masahide Kikkawa, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   143 ( 7 )   2822 - 2828   2021.2

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    Organofullerene amphiphiles show diverse behaviors in water, forming vesicles, micelles, Langmuir-Blodgett films, and anisotropic nanostructures. We found that gradual in situ protonation of an organic solution of (4-heptylphenyl)5C60-K+ by water or buffer generates the corresponding protonated molecule, (4-heptylphenyl)5C60H, which self-assembles to form nano- and microspheres of organofullerene (fullerspheres) with uniform diameters ranging from 30 nm to 2.5 μm that are controlled by the preparation or pH of the buffer. By using an aqueous solution of an organic dye, inorganic nanoparticle, protein, and virus, we encapsulated these entities in the fullersphere. This approach via self-assembly is distinct from other preparations of organic core-shell particles that generally require polymerization for the construction of a robust shell. The sphere is entirely amorphous, thermally stable up to 300 °C under vacuum, and resistant to electron irradiation, and we found the unconventional utility of the sphere for electron tomographic imaging of nanoparticles and biomaterials.

    DOI: 10.1021/jacs.0c11944

    PubMed

    researchmap

  • Capturing the Moment of Emergence of Crystal Nucleus from Disorder Reviewed International journal

    Takayuki Nakamuro, Masaya Sakakibara, Hiroki Nada, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   143 ( 4 )   1763 - 1767   2021.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    Crystallization is the process of atoms or molecules forming an organized solid via nucleation and growth. Being intrinsically stochastic, the research at an atomistic level has been a huge experimental challenge. We report herein in situ detection of a crystal nucleus forming during nucleation/growth of a NaCl nanocrystal, as video recorded in the interior of a vibrating conical carbon nanotube at 20-40 ms frame-1 with localization precision of <0.1 nm. We saw NaCl units assembled to form a cluster fluctuating between featureless and semiordered states, which suddenly formed a crystal. Subsequent crystal growth at 298 K and shrinkage at 473 K took place also in a stochastic manner. Productive contributions of the graphitic surface and its mechanical vibration have been experimentally indicated.

    DOI: 10.1021/jacs.0c12100

    PubMed

    researchmap

  • SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure Reviewed International journal

    Ryo Matsuura, Atsuko Hiraishi, Lawrence B. Holzman, Hiroki Hanayama, Koji Harano, Eiichi Nakamura, Yoshifumi Hamasaki, Kent Doi, Masaomi Nangaku, Eisei Noiri

    Scientific Reports   10 ( 1 )   21103 - 21103   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    <title>Abstract</title>Chronic kidney disease is a public health burden and it remains unknown which genetic loci are associated with kidney function in the Japanese population, our genome-wide association study using the Biobank Japan dataset (excluding secondary kidney diseases, such as diabetes mellitus) clearly revealed that almost half of the top 50 single nucleotide polymorphisms associated with estimated glomerular filtration rate are located in the <italic>SHROOM3</italic> gene, suggesting that <italic>SHROOM3</italic> will be responsible for kidney function. Thus, to confirm this finding, supportive functional analyses were performed on <italic>Shroom3</italic> in mice using fullerene-based siRNA delivery, which demonstrated that <italic>Shroom3</italic> knockdown led to albuminuria and podocyte foot process effacement. The in vitro experiment shows that knockdown of <italic>Shroom3</italic> caused defective formation of lamellipodia in podocyte, which would lead to the disruption of slit diaphragm. These results from the GWAS, in vivo and in vitro experiment were consistent with recent studies reporting that albuminuria leads to impairment of kidney function.

    DOI: 10.1038/s41598-020-77952-9

    PubMed

    researchmap

    Other Link: http://www.nature.com/articles/s41598-020-77952-9

  • Self-Assembly Mechanism in Nucleation Processes of Molecular Crystalline Materials Invited Reviewed

    Koji Harano

    Bulletin of the Chemical Society of Japan   94 ( 2 )   463 - 472   2020.11

     More details

    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/bcsj.20200333

    researchmap

  • Synthesis and Characterization of a Well-Defined Carbon Nanohorn-Supported Molybdenum Dioxo Catalyst by SMART-EM Imaging. Surface Structure at the Atomic Level Reviewed

    Yosi Kratish, Takayuki Nakamuro, Yiqi Liu, Jiaqi Li, Issei Tomotsuka, Koji Harano, Eiichi Nakamura, Tobin J. Marks

    Bulletin of the Chemical Society of Japan   94 ( 2 )   427 - 432   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/bcsj.20200299

    researchmap

  • Aryl Radical Addition to Curvatures of Carbon Nanohorns for Single-Molecule-Level Molecular Imaging Reviewed

    Koji Harano

    Bulletin of the Chemical Society of Japan   93 ( 12 )   1603 - 1608   2020.8

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/bcsj.20200232

    researchmap

  • Ultra-Fast Electron Microscopic Imaging of Single Molecules With a Direct Electron Detection Camera and Noise Reduction Reviewed

    Koji Harano

    Microscopy and Microanalysis   26 ( 4 )   667 - 675   2020.7

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cambridge University Press (CUP)  

    DOI: 10.1017/s1431927620001750

    Scopus

    researchmap

  • Cyclodextrins as Surfactants for Solubilization and Purification of Carbon Nanohorn Aggregates Reviewed

    Hiroki Hanayama, Junya Yamada, Koji Harano, Eiichi Nakamura

    Chemistry – An Asian Journal   15 ( 10 )   1549 - 1552   2020.5

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/asia.202000273

    Scopus

    researchmap

  • Spiro-conjugated Carbon/Heteroatom-bridged p-Phenylenevinylenes: Synthesis, Properties, and Microcrystal Electron Crystallographic Analysis of Racemic Solid Solutions Reviewed

    Koji Harano

    Bulletin of the Chemical Society of Japan   93 ( 6 )   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/bcsj.20200065

    Scopus

    researchmap

  • Atomistic structures and dynamics of prenucleation clusters in MOF-2 and MOF-5 syntheses Reviewed

    Junfei Xing, Luca Schweighauser, Satoshi Okada, Koji Harano, Eiichi Nakamura

    Nature Communications   10 ( 1 )   3608   2019.12

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1038/s41467-019-11564-4

    Scopus

    PubMed

    researchmap

  • Bifurcation of self-assembly pathways to sheet or cage controlled by kinetic template effect Reviewed

    Koji Harano

    Communications Chemistry   2 ( 1 )   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42004-019-0232-2

    Scopus

    researchmap

  • Real-Time Video Imaging of Mechanical Motions of a Single Molecular Shuttle Reviewed

    Toshiki Shimizu, Dominik Lungerich, Joshua Stuckner, Mitsuhiro Murayama, Koji Harano, Eiichi Nakamura

    Bulletin of the Chemical Society of Japan   93 ( 9 )   1079 - 1085   2019.10

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.26434/chemrxiv.10029194.v1

    researchmap

  • Interfacial Chemistry of Conical Fullerene Amphiphiles in Water Reviewed

    Harano, K., Nakamura, E.

    Accounts of Chemical Research   52 ( 8 )   2019.8

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acs.accounts.9b00318

    Scopus

    researchmap

  • Preparation of Hierarchically Assembled Silver Nanostructures based on the Morphologies of Crystalline Peptide-Silver(I) Complexes Reviewed

    Miyake, R., Nitanai, Y., Nakagawa, Y., Xing, J., Harano, K., Nakamura, E., Okabayashi, J., Minamikawa, T., Uruma, K., Kanaizuka, K., Kurihara, M.

    ChemPlusChem   84 ( 3 )   295 - 301   2019.3

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/cplu.201800666

    Scopus

    researchmap

  • Conformational Analysis of Organic Molecules with Single-Molecule Atomic-Resolution Real-Time Transmission Electron Microscopy (SMART-TEM) Imaging Reviewed

    Koji Harano, Eiichi Nakamura

    Molecular Technology   339   2019.2

     More details

    Publisher:Wiley-{VCH} Verlag {GmbH} {\&} Co. {KGaA}  

    DOI: 10.1002/9783527823987.vol4_c12

    researchmap

  • Neutron Scattering Reveals Water Confined in a Watertight Bilayer Vesicle Reviewed

    Abuillan, W., Becker, A.S., Demé, B., Homma, T., Isobe, H., Harano, K., Nakamura, E., Tanaka, M.

    Journal of the American Chemical Society   140 ( 36 )   2018.9

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/jacs.8b04066

    Scopus

    researchmap

  • Hierarchical Assembly of siRNA with Tetraamino Fullerene in Physiological Conditions for Efficient Internalization into Cells and Knockdown Reviewed

    Kosuke Minami, Koji Okamoto, Koji Harano, Eisei Noiri, Eiichi Nakamura

    ACS Applied Materials & Interfaces   10 ( 23 )   19347 - 19354   2018.6

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acsami.8b01869

    researchmap

  • Acid-Responsive Conductive Nanofiber of Tetrabenzoporphyrin Made by Solution Processing Reviewed

    Yonggang Zhen, Kento Inoue, Zongrui Wang, Tetsuro Kusamoto, Koji Nakabayashi, Shin-ichi Ohkoshi, Wenping Hu, Yunlong Guo, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   2018.1

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/jacs.7b10575

    researchmap

  • Chemical kinetics study through observation of individual reaction events with atomic-resolution electron microscopy Reviewed

    Eiichi NAKAMURA, Koji HARANO

    Proceedings of the Japan Academy, Series B   94 ( 10 )   428 - 440   2018

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Japan Academy  

    DOI: 10.2183/pjab.94.028

    researchmap

  • Flexibility of components alters the self-assembly pathway of Pd2L4 coordination cages Reviewed

    Shumpei Kai, Sai Prakash Maddala, Tatsuo Kojima, Shota Akagi, Koji Harano, Eiichi Nakamura, Shuichi Hiraoka

    Dalton Transactions   2018

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/C8DT00112J

    researchmap

  • A pyrazine-incorporated graphdiyne nanofilm as a metal-free electrocatalyst for the hydrogen evolution reaction Reviewed

    Ryota Sakamoto, Ryo Shiotsuki, Keisuke Wada, Naoya Fukui, Hiroaki Maeda, Joe Komeda, Ryosuke Sekine, Koji Harano, Hiroshi Nishihara

    Journal of Materials Chemistry A   2018

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/C8TA07347C

    researchmap

  • Direct Microscopic Analysis of Individual C60 Dimerization Events: Kinetics and Mechanisms Reviewed

    Satoshi Okada, Satori Kowashi, Luca Schweighauser, Kaoru Yamanouchi, Koji Harano, Eiichi Nakamura

    Journal of the American Chemical Society   139 ( 50 )   18281 - 18287   2017.12

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b09776

    Web of Science

    researchmap

  • Bis(dipyrrinato)zinc(II) Complex Chiroptical Wires: Exfoliation into Single Strands and Intensification of Circularly Polarized Luminescence Reviewed

    Risa Aoki, Ryojun Toyoda, Julius F. Kögel, Ryota Sakamoto, Jatish Kumar, Yasutaka Kitagawa, Koji Harano, Tsuyoshi Kawai, Hiroshi Nishihara

    Journal of the American Chemical Society   139 ( 45 )   16024 - 16027   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b07077

    Web of Science

    researchmap

  • Heterogeneous catalase-like activity of gold(I)-cobalt(III) metallosupramolecular ionic crystals Reviewed

    Yamada, Mihoko, Yoshinari, Nobuto, Kuwamura, Naoto, Saito, Toru, Okada, Satoshi, Maddala, Sai Prakash, Harano, Koji, Nakamura, Eiichi, Yamagami, Kohei, Yamanaka, Keisuke, Sekiyama, Akira, Suenobu, Tomoyoshi, Yamada, Yusuke, Konno, Takumi

    Chemical Science   8 ( 4 )   2671 - 2676   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c6sc04993a

    Web of Science

    researchmap

  • Conical Ionic Amphiphiles Endowed with Micellization Ability but Lacking Air-Water and Oil-Water Interfacial Activity Reviewed

    Nitta, Hirohisa, Harano, Koji, Isomura, Mayuko, Backus, Ellen H. G., Bonn, Mischa, Nakamura, Eiichi

    Journal of the American Chemical Society   139 ( 23 )   7677 - 7680   2017

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b01596

    Web of Science

    researchmap

  • Experimental study on interconversion between cubic MOF-5 and square MOF-2 arrays Reviewed

    Schweighauser, Luca, Harano, Koji, Nakamura, Eiichi

    Inorganic Chemistry Communications   84   1 - 4   2017

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.inoche.2017.07.009

    Web of Science

    researchmap

  • Supramolecular Differentiation for Construction of Anisotropic Fullerene Nanostructures by Time-Programmed Control of Interfacial Growth Reviewed

    Purtha Bairi, Kosuke Minami, Jonathan P. Hill, Waka Nakanishi, Lok Kumar Shrestha, Chao Liu, Koji Harano, Eiichi Nakamura, Katsuhiko Ariga

    ACS NANO   10 ( 9 )   8796 - 8802   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsnano.6b04535

    Web of Science

    PubMed

    researchmap

  • Nanoscale Control of Polymer Assembly on a Synthetic Catalyst-Bilayer System Reviewed

    Gorgoll, Ricardo M., Harano, Koji, Nakamura, Eiichi

    Journal of the American Chemical Society   138 ( 30 )   9675 - 9681   2016

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.6b05414

    Web of Science

    PubMed

    researchmap

  • Chemical Pathways Connecting Lead(II) Iodide and Perovskite via Polymeric Plumbate(II) Fiber Reviewed

    Yunlong Guo, Kazutaka Shoyama, Wataru Sato, Yutaka Matsuo, Kento Inoue, Koji Harano, Chao Liu, Hideyuki Tanaka, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 50 )   15907 - 15914   2015.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.5b10599

    Web of Science

    PubMed

    researchmap

  • Cooperative Self-Assembly of Gold Nanoparticles on the Hydrophobic Surface of Vesicles in Water Reviewed

    Ricardo M. Gorgoll, Takuya Tsubota, Koji Harano, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 24 )   7568 - 7571   2015.6

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.5b03632

    Web of Science

    PubMed

    researchmap

  • Gold Nanoparticles: Fabrication of NIR-Excitable SERS-Active Composite Particles Composed of Densely Packed Au Nanoparticles on Polymer Microparticles (Part. Part. Syst. Charact. 4/2015) Reviewed

    Masaaki Kanahara, Hiroki Satoh, Takeshi Higuchi, Atsushi Takahara, Hiroshi Jinnai, Koji Harano, Satoshi Okada, Eiichi Nakamura, Yasutaka Matsuo, Hiroshi Yabu

    Particle & Particle Systems Characterization   32 ( 4 )   401   2015.4

     More details

    Publisher:Wiley-Blackwell  

    DOI: 10.1002/ppsc.201570012

    researchmap

  • Fabrication of NIR-Excitable SERS-Active Composite Particles Composed of Densely Packed Au Nanoparticles on Polymer Microparticles Reviewed

    Masaaki Kanahara, Hiroki Satoh, Takeshi Higuchi, Atsushi Takahara, Hiroshi Jinnai, Koji Harano, Satoshi Okada, Eiichi Nakamura, Yasutaka Matsuo, Hiroshi Yabu

    PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION   32 ( 4 )   441 - 447   2015.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ppsc.201400191

    Web of Science

    researchmap

  • Fabrication of NIR-Excitable SERS-Active Composite Particles Composed of Densely Packed Au Nanoparticles on Polymer Microparticles Reviewed

    Masaaki Kanahara, Hiroki Satoh, Takeshi Higuchi, Atsushi Takahara, Hiroshi Jinnai, Koji Harano, Satoshi Okada, Eiichi Nakamura, Yasutaka Matsuo, Hiroshi Yabu

    Particle & Particle Systems Characterization   32 ( 4 )   441 - 447   2015.4

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ppsc.201400191

    Web of Science

    researchmap

  • Electron Microscopic Observation of Selective Excitation of Conformational Change of a Single Organic Molecule Reviewed

    Ricardo M. Gorgoll, Emrah Yucelen, Akihito Kumamoto, Naoya Shibata, Koji Harano, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 10 )   3474 - 3477   2015.3

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.5b00511

    Web of Science

    PubMed

    researchmap

  • DNA Binding of Pentaamino[60]fullerene Synthesized Using Click Chemistry Reviewed

    Hirohisa Nitta, Kosuke Minami, Koji Harano, Eiichi Nakamura

    CHEMISTRY LETTERS   44 ( 3 )   378 - 380   2015.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.141092

    Web of Science

    researchmap

  • Organic Solid Solution Composed of Two Structurally Similar Porphyrins for Organic Solar Cells Reviewed

    Yonggang Zhen, Hideyuki Tanaka, Koji Harano, Satoshi Okada, Yutaka Matsuo, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 6 )   2247 - 2252   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja513045a

    Web of Science

    PubMed

    researchmap

  • High-Density Display of Protein Ligands on Self-Assembled Capsules via Noncovalent Fluorous Interactions Reviewed

    Koji Harano, Junya Yamada, Shinichiro Mizuno, Eiichi Nakamura

    CHEMISTRY-AN ASIAN JOURNAL   10 ( 1 )   172 - 176   2015.1

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201403144

    Web of Science

    PubMed

    researchmap

  • Photocrosslinking of the Exterior of a Fullerene Bilayer that Prevents Vesicle Aggregation Reviewed

    Koji Harano, Akimitsu Narita, Eiichi Nakamura

    CHEMISTRY LETTERS   43 ( 6 )   877 - 879   2014.6

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.140143

    Web of Science

    researchmap

  • Formation of a Polycrystalline Film of Donor Material on PEDOT: PSS Buffer Induced by Crystal Nucleation Reviewed

    Koji Harano, Satoshi Okada, Shunsuke Furukawa, Hideyuki Tanaka, Eiichi Nakamura

    JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS   52 ( 12 )   833 - 841   2014.6

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/polb.23493

    Web of Science

    researchmap

  • siRNA delivery targeting to the lung via agglutination-induced accumulation and clearance of cationic tetraamino fullerene Reviewed

    Kosuke Minami, Koji Okamoto, Kent Doi, Koji Harano, Eisei Noiri, Eiichi Nakamura

    SCIENTIFIC REPORTS   4   4916   2014.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep04916

    Web of Science

    PubMed

    researchmap

  • Conformational Analysis of Single Perfluoroalkyl Chains by Single-Molecule Real-Time Transmission Electron Microscopic Imaging Reviewed

    Koji Harano, Shinya Takenaga, Satoshi Okada, Yoshiko Niimi, Naohiko Yoshikai, Hiroyuki Isobe, Kazu Suenaga, Hiromichi Kataura, Masanori Koshino, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   136 ( 1 )   466 - 473   2014.1

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja411235x

    Web of Science

    PubMed

    researchmap

  • Enhancement in the efficiency of an organic-inorganic hybrid solar cell with a doped P3HT hole-transporting layer on a void-free perovskite active layer Reviewed

    Yunlong Guo, Chao Liu, Kento Inoue, Koji Harano, Hideyuki Tanaka, Eiichi Nakamura

    JOURNAL OF MATERIALS CHEMISTRY A   2 ( 34 )   13827 - 13830   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c4ta02976c

    Web of Science

    researchmap

  • Photocrosslinking of Fullerene Vesicles that Prevents Phase Transition and Decreases Water Permeation Reviewed

    Koji Harano, Akimitsu Narita, Eiichi Nakamura

    CHEMISTRY LETTERS   42 ( 10 )   1176 - 1178   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.130505

    Web of Science

    researchmap

  • Polymer Janus particles containing block-copolymer stabilized magnetic nanoparticles Reviewed

    Hiroshi Yabu, Masaaki Kanahara, Masatsugu Shimomura, Toshihiko Arita, Koji Harano, Eiichi Nakamura, Takeshi Higuchi, Hiroshi Jinnai

    ACS Applied Materials and Interfaces   5 ( 8 )   3262 - 3266   2013.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/am4003149

    Scopus

    PubMed

    researchmap

    Other Link: http://orcid.org/0000-0001-6800-8023

  • Magnetic Janus Microparticles: Preparation of Phase-separated Polymer Blend Particles Containing Magnetic Nanoparticles Reviewed

    Hiroshi Yabu, Masaaki Kanahara, Masatsugu Shimomura, Toshihiko Arita, Koji Harano, Eiichi Nakamura, Takeshi Higuchi, Hiroshi Jinnai

    ACS Applied Materials and Interfaces   5 ( 8 )   3262 - 3266   2013.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    7536

    researchmap

  • Binding of aromatic molecules in the fullerene-rich interior of a fullerene bilayer vesicle in water Reviewed

    Koji Harano, Ricardo Mizoguchi Gorgoll, Eiichi Nakamura

    CHEMICAL COMMUNICATIONS   49 ( 69 )   7629 - 7631   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c3cc44510k

    Web of Science

    PubMed

    researchmap

  • Protein-coated nanocapsules via multilevel surface modification. Controlled preparation and microscopic analysis at nanometer resolution Reviewed

    Koji Harano, Kosuke Minami, Eisei Noiri, Koji Okamoto, Eiichi Nakamura

    CHEMICAL COMMUNICATIONS   49 ( 34 )   3525 - 3527   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c3cc40752g

    Web of Science

    PubMed

    researchmap

  • Heterogeneous nucleation of organic crystals mediated by single-molecule templates Reviewed

    Koji Harano, Tatsuya Homma, Yoshiko Niimi, Masanori Koshino, Kazu Suenaga, Ludwik Leibler, Eiichi Nakamura

    NATURE MATERIALS   11 ( 10 )   877 - 881   2012.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/NMAT3408

    Web of Science

    researchmap

  • Preparation and Properties of Vesicles Made of Nonpolar/Polar/Nonpolar Fullerene Amphiphiles Reviewed

    Tatsuya Homma, Koji Harano, Hiroyuki Isobe, Eiichi Nakamura

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   133 ( 16 )   6364 - 6370   2011.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja200498g

    Web of Science

    researchmap

  • Nanometer-Sized Fluorous Fullerene Vesicles in Water and on Solid Surfaces Reviewed

    Tatsuya Homma, Koji Harano, Hiroyuki Isobe, Eiichi Nakamura

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   49 ( 9 )   1665 - 1668   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200904659

    Web of Science

    researchmap

  • Induced-Fit Formation of a Tetrameric Organic Capsule Consisting of Hexagram-Shaped Amphiphile Molecules

    Shuichi Hiraoka, Koji Harano, Takashi Nakamura, Motoo Shiro, Mitsuhiko Shionoya

    Angewandte Chemie   121 ( 38 )   7140 - 7143   2009.9

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1002/ange.200902652

    researchmap

  • Induced-Fit Formation of a Tetrameric Organic Capsule Consisting of Hexagram-Shaped Amphiphile Molecules Reviewed

    Shuichi Hiraoka, Koji Harano, Takashi Nakamura, Motoo Shiro, Mitsuhiko Shionoya

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   48 ( 38 )   7006 - 7009   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200902652

    Web of Science

    researchmap

  • Mono- and Penta-Addition of Enol Silyl Ethers to [60]Fullerene Reviewed

    Eiichi Nakamura, Shinsuke Mouri, Yuki Nakamura, Koji Harano, Hiroyuki Isobe

    ORGANIC LETTERS   10 ( 21 )   4923 - 4926   2008.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ol8020379

    Web of Science

    researchmap

  • A Self-Assembled Organic Capsule Formed from the Union of Six Hexagram-Shaped Amphiphile Molecules Reviewed

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Mitsuhiko Shionoya

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 44 )   14368 - +   2008.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja804885k

    Web of Science

    researchmap

  • Imaging of conformational changes of biotinylated triamide molecules covalently bonded to a carbon nanotube surface Reviewed

    Eiichi Nakamura, Masanori Koshino, Takatsugu Tanaka, Yoshiko Niimi, Koji Harano, Yuki Nakamura, Hiroyuki Isobe

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 25 )   7808 - +   2008.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja8022708

    Web of Science

    researchmap

  • 3 nm-scale molecular switching between fluorescent coordination capsule and nonfluorescent cage Reviewed

    Koji Harano, Shuichi Hiraoka, Mitsuhiko Shionoya

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   129 ( 17 )   5300 - +   2007.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja0659727

    Web of Science

    researchmap

  • Titelbild: Isostructural Coordination Capsules for a Series of 10 Different d5–d10 Transition-Metal Ions (Angew. Chem. 39/2006)

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Yoshiki Ozawa, Nobuhiro Yasuda, Koshiro Toriumi, Mitsuhiko Shionoya

    Angewandte Chemie   118 ( 39 )   6553 - 6553   2006.10

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1002/ange.200690134

    researchmap

  • Cover Picture: Isostructural Coordination Capsules for a Series of 10 Different d5–d10 Transition-Metal Ions (Angew. Chem. Int. Ed. 39/2006)

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Yoshiki Ozawa, Nobuhiro Yasuda, Koshiro Toriumi, Mitsuhiko Shionoya

    Angewandte Chemie International Edition   45 ( 39 )   6403 - 6403   2006.10

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1002/anie.200690134

    researchmap

  • Isostructural Coordination Capsules for a Series of 10 Different d5–d10 Transition-Metal Ions Reviewed

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Yoshiki Ozawa, Nobuhiro Yasuda, Koshiro Toriumi, Mitsuhiko Shionoya

    Angewandte Chemie   118 ( 39 )   6638   2006.10

     More details

    Publisher:Wiley-Blackwell  

    DOI: 10.1002/ange.200601431

    researchmap

  • Isostructural coordination capsules for a series of 10 different d(5)-d(10) transition-metal ions Reviewed

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Yoshiki Ozawa, Nobuhiro Yasuda, Koshiro Toriumi, Mitsuhiko Shionoya

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   45 ( 39 )   6488 - 6491   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200601431

    Web of Science

    researchmap

  • Quantitative Dynamic Interconversion between AgI-Mediated Capsule and Cage Complexes Accompanying Guest Encapsulation/Release

    Shuichi Hiraoka, Koji Harano, Motoo Shiro, Mitsuhiko Shionoya

    Angewandte Chemie   117 ( 18 )   2787 - 2791   2005.4

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1002/ange.200462394

    researchmap

  • Quantitative dynamic interconversion between Ag-I-mediated capsule and cage complexes accompanying guest encapsulation/release Reviewed

    S Hiraoka, K Harano, M Shiro, M Shionoya

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   44 ( 18 )   2727 - 2731   2005

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200462394

    Web of Science

    researchmap

  • Quantitative formation of sandwich-shaped trinuclear silver(Iota) complexes and dynamic nature of their P reversible arrow M flip motion in solution Reviewed

    S Hiraoka, K Harano, T Tanaka, M Shiro, M Shionoya

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   42 ( 42 )   5182 - 5185   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200351068

    Web of Science

    researchmap

▼display all

MISC

  • 単分子・分子集合体観察のための電子顕微鏡技術 Invited Reviewed

    原野幸治

    化学と工業   79 ( 1 )   19 - 21   2026.1

     More details

    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    researchmap

  • RhRu酸化物クラスター触媒によるアレーンのC-H結合活性化

    長谷川慎吾, 原野幸治, 本倉健

    ナノ学会大会講演予稿集   23rd   2025

  • IrAu12クラスターのプログラム集積化:透過電子顕微鏡による直接観察と光学特性の変調

    福本優斗, 高野慎二郎, 浅見陽介, 平井遥, 原野幸治, 佃達哉

    ナノ学会大会講演予稿集   23rd   2025

  • Structure and Properties of Exfoliatable 2D Quinhydrone-Type Complexes Formed from Propeller-Shaped Molecules

    敦賀柊太, 敦賀柊太, 竹原陵介, 竹原陵介, 竹原陵介, 庄子良晃, 庄子良晃, 庄子良晃, 矢澤宏次, 原野幸治, 福島孝典, 福島孝典, 福島孝典

    分子科学討論会講演プログラム&要旨(Web)   19th   2025

  • Lyotropic Liquid Crystals via Amphiphilic Charge-by-Charge Assembly

    丸山優斗, MANNA Biplab, 原野幸治, 石田康博, 前田大光

    ホスト-ゲスト・超分子化学シンポジウム講演要旨集   22nd   2025

  • Stacking control of chlorophyll rosettes by generations of dendritic side chains

    工藤稜央, 民秋均, 原野幸治, 花山博紀, 矢貝史樹

    日本化学会春季年会講演予稿集(Web)   105th   2025

  • Soft organic paramagnet in water: a supramolecular approach based on amphiphilic nickel dithiolene complex salt

    藤野智子, 菱田真史, 伊藤雅聡, 中村敏和, 浅田瑞枝, 倉橋直也, 木内久雄, 原田慈久, 原野幸治, 牧浦理恵, 武野カノクワン, 横森創, 大池広志, 森初果

    日本化学会春季年会講演予稿集(Web)   105th   2025

  • Toward the Era of Visualizing Chemical Reactions : Cinematic Chemistry Enabled by High-Speed Atomic-Resolution Electron Microscopy

    清水俊樹, 原野幸治, 中村栄一

    表面と真空   68 ( 8 )   2025

  • Encapsulation of metal ions inside supramolecular nanotube of hydrophilic athracene dyads

    矢貝史樹, 宮脇舜, 花山博紀, 原野幸治

    日本化学会春季年会講演予稿集(Web)   105th   2025

  • Soft organic paramagnet in water: a supramolecular approach based on amphiphilic nickel dithiolene complex salt

    藤野智子, 菱田真史, 伊藤雅聡, 中村敏和, 浅田瑞枝, 倉橋直也, 木内久雄, 原田慈久, 原野幸治, 牧浦理恵, 武野カノクワン, 横森創, 大池広志, 森初果

    日本物理学会講演概要集(CD-ROM)   80 ( 1 )   2025

  • IrAu12 Clusters with Exposed Site(s): Precise Synthesis and Programmed Linkage

    福本優斗, 重田翼, 平井遥, 高野慎二郎, 原野幸治, 佃達哉

    ナノ学会会報(Web)   23 ( 1 )   2024

  • Lyotropic Liquid Crystals Based on Charge-by-Charge Assembly of Amphiphilic π-Electronic Ion Pairs

    丸山優斗, 原野幸治, 金井逸人, 石田康博, 前田大光

    ホスト-ゲスト・超分子化学シンポジウム講演要旨集   21st (Web)   2024

  • High-contrast TEM images by combining Wavelet and PCA

    上杉文彦, 原野幸治, 木本浩司, 石井真史

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   85th   2024

  • Unique electronic properties of amphiphilic nickel dithiolene complex salt assembled in aqua

    藤野智子, 菱田真史, 伊藤雅聡, 中村敏和, 浅田瑞枝, 倉橋直也, 木内久雄, 原田慈久, 原野幸治, 牧浦理恵, 武野カノクワン, 横森創, 森初果

    日本物理学会講演概要集(CD-ROM)   78 ( 2 )   2023

  • 単分子の構造,運動および化学反応を透過電子顕微鏡でとらえる

    原野幸治

    日本表面真空学会東北・北海道支部学術講演会講演予稿集   2022 (CD-ROM)   2023

  • Unique electronic properties of amphiphilic nickel dithiolene complex salt assembled in aqua

    藤野智子, 菱田真史, 伊藤雅聡, 中村敏和, 浅田瑞枝, 倉橋直也, 木内久雄, 原田慈久, 原野幸治, 牧浦理恵, 武野カノクワン, 横森創, 森初果

    分子科学討論会講演プログラム&要旨(Web)   17th   2023

  • Mechanism of chemical reactions inside the nano-flask revealed by single-molecule kinetic study

    LIU Dongxin, 小鷲智理, 中室貴幸, LUNGERICH Dominik, 山内薫, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   32nd (CD-ROM)   2022

  • 原子番号相関(ZC)分子模型の提案-新時代の化学教育・研究のための分子描画パラメータ

    原野幸治, 中村栄一

    化学   77 ( 8 )   2022

  • Atomic-Number-Correlated Molecular Model for Deciphering Transmission Electron Microscopic Images

    原野幸治, XING Junfei, 竹内啓志, 亀井恒, 中室貴幸, 中村栄一

    日本化学会春季年会講演予稿集(Web)   102nd   2022

  • Electron microscopic study for guest binding modes of cyclodextrins

    原野幸治

    シクロデキストリンシンポジウム講演要旨集   38th   2022

  • Single Molecule Dynamics in Peptide Aggregation Process Explored by Molecular Fishhook

    中室貴幸, 亀井恒, SUN Keyi, BODE Jeffrey W., 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   32nd (CD-ROM)   2022

  • Identification and thermodynamics of rim binding modes of cyclodextrins by atomic-resolution electron microscopy

    花山博紀, 山田純也, 原野幸治, 中村栄一

    日本化学会春季年会講演予稿集(Web)   101st   2021

  • Geometrical Structure and Aerobic Oxidation Catalysis of PVP-Stabilized Au24 Cluster

    長谷川慎吾, 高野慎二郎, 原野幸治, 佃達哉, 佃達哉

    ナノ学会大会講演予稿集   19th   2021

  • Capturing the Moment of Crystal Nucleation and Tracing the Crystal Growth by Single-molecule Observation

    中室貴幸, 榊原雅也, 灘浩樹, 原野幸治, 中村栄一

    結晶成長国内会議予稿集(CD-ROM)   50th   2021

  • Electron Microscopic Study of Dynamic Processes of Organic Molecules and their Assemblies

    原野幸治

    基礎有機化学討論会要旨集   31st (CD-ROM)   2021

  • 分子映像から迫る結晶化現象における単分子挙動

    中室貴幸, 榊原雅也, 灘浩樹, 原野幸治, 中村栄一

    日本結晶学会年会講演要旨集   2021   2021

  • Hydrogen-Bonded Two-Dimensional Supramolecular Polymers as Ultrathin and Flexible Large-Area Proton-Conducting Films

    内田光, RAVAT Prince, 関根良輔, 亀井恒, 山本暁久, KONOVALOV Oleg, 田中求, 田中求, 山田鉄兵, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   31st (CD-ROM)   2021

  • Size-selective Guest Binding Controlled by Rim Modification of Cyclodextrins

    緒方嵩隼, 花山博紀, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   31st (CD-ROM)   2021

  • Direct Observation of NaCl Surface Cluster Dynamics under Crystal Growth

    榊原雅也, 中室貴幸, 灘浩樹, 原野幸治, 中村栄一

    結晶成長国内会議予稿集(CD-ROM)   50th   2021

  • 単分子原子分解能実時間電子顕微鏡法による化学反応研究 (特集 分子を見る最前線 : 測定手法の革新と"新"化学の発見)

    原野 幸治, 中村 栄一

    化学と工業 = Chemistry & chemical industry   73 ( 1 )   16 - 18   2020.1

     More details

    Language:Japanese   Publisher:日本化学会  

    CiNii Books

    J-GLOBAL

    researchmap

  • アスファルテン凝集挙動解析の20年

    田中隆三, 田中隆三, 熊谷治夫, 鷹觜利公, 森本正人, 麓恵理, 佐藤信也, 原野幸治, 森田剛, 山本秀樹, 鈴木昭雄

    石油・石油化学討論会講演要旨   50th (Web)   2020

  • アスファルテン凝集体を構成する分子構造のHansen溶解度パラメータの推算

    原田孝太, 山本秀樹, 森本正人, 森田剛, 熊谷治夫, 原野幸治, 鈴木昭雄, 田中隆三, 田中隆三

    石油・石油化学討論会講演要旨   50th (Web)   2020

  • 世界最高速の動画撮影でひもとく分子の世界-カメラは見た!分子が動く決定的瞬間

    清水俊樹, 原野幸治, 中村栄一

    化学   75 ( 11 )   2020

  • 目に見えない微結晶の構造を解析する!―マイクロ電子回折で三次元分子構造を決定

    原野幸治, 劉東欣, 中室貴幸, 中村栄一

    化学   74 ( 5 )   49‐53   2019.5

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • Visualization of Individual Asphaltene Molecules

    原野幸治

    日本エネルギー学会機関誌   98 ( 6 )   2019

  • カーボンナノチューブを介したエネルギー伝達による分子の選択的電子励起

    LIU Dongxin, LUNGERICH Dominik, 小鷲智理, 小野ゆり子, 武次徹也, 山内薫, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   30th   2019

  • 非包接型相互作用を介したシクロデキストリンによる疎水性物質の可溶化

    花山博紀, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   30th   2019

  • 化学反応を顕微鏡で追跡する時代が到来

    岡田賢, 原野幸治, 山内薫, 中村栄一, 中村栄一

    現代化学   ( 566 )   27‐31   2018.5

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • 原子分解能顕微鏡で化学反応機構を調べる!―一体いくつの分子を調べればよいのだろうか

    岡田賢, 山内薫, 原野幸治, 中村栄一

    化学   73 ( 4 )   12‐16   2018.4

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • 原子分解能顕微鏡で化学反応機構を調べる!−量子力学が予言した化学反応理論の実験的実証

    岡田賢, 山内薫, 原野幸治, 中村栄一

    化学   73 ( 4 )   12 - 15   2018.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

    researchmap

  • 学部生に伝える研究最前線

    岩崎 渉, 中村 栄一, 原野 幸治, 山内 薫, 田近 英一, 尾崎 和海

    東京大学理学系研究科・理学部ニュース   49 ( 6 )   11 - 13   2018.3

     More details

    Language:Japanese   Publisher:東京大学大学院理学系研究科・理学部  

    生物世界を俯瞰する生物情報科学/原子分解能顕微鏡で化学反応を追跡する!―量子力学が教える化学反応理論の実験的実証―/原始微生物生態系が太古の地球を温暖に保った?

    CiNii Books

    researchmap

  • 透過電子顕微鏡の加速電圧で制御するフラーレンの選択的電子励起

    LIU Dongxin, LUNGERICH Dominik, 小鷲智理, 山内薫, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   29th   2018

  • 原子分解能電子顕微鏡によるナノカーボン表面の曲面選択的なラジカル付加反応の解析

    亀井恒, 清水俊樹, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   29th   2018

  • 中性子散乱法で明らかにしたフラーレン二重膜ベシクルに束縛されたナノ水相

    原野幸治, ABUILLAN Wasim, BECKER Alexandra S., DEME Bruno, 本間達也, 磯部寛之, 中村栄一, 田中求, 田中求

    基礎有機化学討論会要旨集   29th   2018

  • 茶わんの湯から考える最新科学(7)お茶のなかの分子世界

    原野幸治

    現代化学   ( 556 )   42 - 45   2017.7

     More details

  • シクロデキストリンによるナノカーボン表面認識と原子分解能顕微鏡による複合体構造解析

    花山博紀, 山田純也, 清水俊樹, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   28th   2017

  • 光還元反応による環状金属錯体集積型多孔性結晶-金ナノ粒子複合体の合成と構造・機能解析

    山下優太郎, 田代省平, 関根良輔, 原野幸治, 中村栄一, 塩谷光彦

    錯体化学会討論会講演要旨集   67th   2017

  • AuI4CoIII2金属超分子イオン結晶のカタラーゼ様不均一触媒活性

    山田美穂子, 吉成信人, 桑村直人, 齋藤徹, 岡田賢, MADDALA Sai Prakash, 原野幸治, 中村栄一, 山神光平, 山中恵介, 関山明, 末延知義, 末延知義, 山田裕介, 今野巧

    錯体化学会討論会講演要旨集   67th   2017

  • コーン型両親媒性フラーレン:気液・液液界面活性をもたないミセル形成分子

    原野幸治, 新田寛久, 磯村真由子, BACKUS Ellen H., BONN Mischa, 中村栄一

    基礎有機化学討論会要旨集   28th   2017

  • フラーレン自己集合膜で被覆したマイクロメートルサイズ水粒子の単離と特異な熱安定性

    関根良輔, MADDALA Sai Prakash, 柳澤春明, 吉川雅英, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   28th   2017

  • 原子分解能電子顕微鏡動画撮影による[60]フラーレン二量化反応の速度論的解析

    小鷲智理, 岡田賢, SCHWEIGHAUSER Luca, 原野幸治, 山内薫, 中村栄一

    基礎有機化学討論会要旨集   28th   2017

  • テトラベンゾポルフィリンのラジカル含有ナノファイバー形成と導電性スイッチング

    井上健仁, ZHEN Yonggang, GUO Yunlong, 原野幸治, 中林耕二, 大越慎一, 中村栄一

    基礎有機化学討論会要旨集   27th   261   2016.9

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • 電子顕微鏡科学を基盤とした有機分子集合体の構造解析と機能開発

    原野幸治, 原野幸治

    日本化学会春季年会講演予稿集(CD-ROM)   96th   2016

  • 電荷分離型AuI4CoIII2イオン結晶のカタラーゼ様触媒活性

    山田美穂子, 吉成信人, 岡田賢, MADDARA Sai Prakash, 原野幸治, 中村栄一, 末延知義, 山田裕介, 福住俊一, 今野巧

    日本化学会春季年会講演予稿集(CD-ROM)   96th   2016

  • ペプチド銀錯体結晶の形状を反映した銀粒子の合成

    三宅亮介, 三宅亮介, 中川結希, 佐久間高央, 原野幸治, 中村栄一

    錯体化学会討論会講演要旨集   66th   2016

  • テトラベンゾポルフィリンラジカルのナノワイヤ形成と導電性スイッチング

    井上健仁, ZHEN Yonggang, GUO Yunlong, 原野幸治, 中村栄一

    日本化学会春季年会講演予稿集(CD-ROM)   96th   2016

  • 高分解能電子顕微鏡で切り開くナノ・メゾ分子集合体科学

    原野幸治, 原野幸治

    日本化学会春季年会講演予稿集(CD-ROM)   96th   2016

  • 人工二重膜・触媒複合系によるポリマー集合体のナノスケール形態制御

    原野幸治, MIZOGUCHI GORGOLL Ricardo, 中村栄一

    基礎有機化学討論会要旨集   27th   2016

  • 水分散性サブミクロン粒子から調製した芳香族炭化水素固体の発光挙動

    庄山和隆, LIU Chao, 原野幸治, 中村栄一, 中村栄一

    日本化学会講演予稿集   95th ( 3 )   2015

  • 「有機結晶化学」共和国の多様な世界―結晶構造と性質 結晶はどのようにしてできるか

    HARANO KOJI

    化学と教育   63 ( 8 )   384 - 387   2015

     More details

  • シクロデキストリンのナノカーボン表面への形状選択的結合と単分子電子顕微鏡観察

    山田純也, 熊本明仁, 柴田直哉, 原野幸治, 中村栄一, 中村栄一

    基礎有機化学討論会要旨集   26th   2015

  • 低加速電圧で誘起される単一有機分子配座変換の電子顕微鏡観察

    原野幸治, GORGOLL Ricardo Mizoguchi, YUECELEN Emrah, 熊本明仁, 柴田直哉, 中村栄一, 中村栄一

    基礎有機化学討論会要旨集   26th   2015

  • ホール輸送性ポリ(3-ヘキシルチオフェン)を用いたペロブスカイト太陽電池

    田中秀幸, GUO Yunlong, LIU Chao, 井上健仁, 原野幸治, 中村栄一

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   2014

  • フルオラス表面での分子認識を利用した非極性気体応答性分子放出システム

    山田純也, 関貴一, 岡田朋子, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   25th   2014

  • 単分子実時間TEMイメージングによる個々の有機分子に対する配座解析

    原野幸治, 武永真也, 岡田賢, 新見佳子, 吉戒直彦, 磯部寛之, 末永和知, 片浦弘道, 越野雅至, 中村栄一

    基礎有機化学討論会要旨集   25th   2014

  • 基板表面の化学修飾による有機ナノ結晶の核形成および結晶形態制御

    岡田賢, 原野幸治, 古川俊輔, 田中秀幸, 中村栄一

    基礎有機化学討論会要旨集   25th   2014

  • π電子研究の歴史と将来展望

    HARANO KOJI, NAKAMURA EIICHI

    CSJ Curr Rev   ( 12 )   20 - 24   2013.3

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • 研究ニュース

    中村 栄一, 原野 幸治, 加藤 一希, 濡木 理

    東京大学理学系研究科・理学部ニュース   44 ( 5 )   10 - 11   2013.1

     More details

    Language:Japanese   Publisher:東京大学大学院理学系研究科・理学部  

    分子はどのようにして結晶化するのだろうか?/遺伝性骨疾患の発症メカニズムの一端を解明

    CiNii Books

    researchmap

  • 光捕集に向けた分子アロイの創成と塗布型有機太陽電池の高効率化

    田中秀幸, ZHEN Yonggang, 原野幸治, 岡田賢, 松尾豊, 中村栄一

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   2013

  • 多段階表面修飾によるタンパク質被膜フラーレン二重膜ベシクルの構築

    南皓輔, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   24th   2013

  • フルオラス相互作用を用いた表面機能化水溶性ナノカプセルの構築

    山田純也, 水野慎一郎, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   24th   2013

  • 両親媒性コニカルフラーレンの自己集合挙動と超分子構造

    新田寛久, 原野幸治, 中村栄一

    基礎有機化学討論会要旨集   24th   2013

  • 水溶性フラーレン誘導体を用いた肺選択的siRNAデリバリー

    南皓輔, 原野幸治, 岡本好司, 野入英世, 土井研人, 中村栄一

    日本化学会講演予稿集   93rd ( 3 )   2013

  • 単分子をテンプレートとした有機結晶の不均一核形成

    原野幸治, 本間達也, 新見佳子, 越野雅至, 末永和知, LEIBLER Ludwik, 中村栄一

    基礎有機化学討論会要旨集   24th   2013

  • 分子レベルで設計された結晶化サイトからの有機結晶成長

    原野幸治, 本間達也, 新見佳子, 越野雅至, 末永和知, LEIBLER Ludwik, 中村栄一

    日本化学会講演予稿集   92nd ( 3 )   2012

  • フラーレンベシクルの調製後修飾によるビオチン化とその生体分子認識挙動の解析

    南皓輔, 原野幸治, 中村栄一

    日本化学会講演予稿集   92nd ( 3 )   2012

  • 両親媒性五重付加型[60]フラーレン誘導体の自己集合によるナノ粒子の形成

    新田寛久, 原野幸治, 中村栄一

    日本化学会講演予稿集   92nd ( 3 )   2012

  • カチオン性アミノフラーレンを用いたsiRNAデリバリー

    南皓輔, 岡本好司, 野入英世, 原野幸治, 中村栄一

    日本DDS学会学術集会プログラム予稿集   28th   2012

  • 塗布熱変換によるポリマー表面のグラフェン修飾および表面上におけるπ共役有機分子の結晶化制御

    岡田賢, 田中秀幸, 古川俊輔, 原野幸治, 中村栄一

    日本化学会講演予稿集   92nd ( 2 )   2012

  • Control of membrane permeability by photomodification of fullerene bilayer membrane

    Harano Koji, Narita Akimitsu, Nakamura Eiichi

    Abstracts of Symposium on Physical Organic Chemistry   2010 ( 0 )   A26 - A26   2011

     More details

    Language:Japanese   Publisher:The Society of Physical Organic Chemistry, Japan  

    Bilayer vesicles made of amphiphilic fullerene Ph5C60K were photochemically modified in two ways, that is, post- and pre-modification to control membrane properties. Post-modification by UV irradiation to preformed vesicles reduced the water permeability due to photoaddition reactions in the fullerene membrane. On the other hand, pre-modification via photomodification of Ph5C60K prior to the vesicle formation enhanced the water permeation by photooxidation of the fullerene cores. Thermodynamic analyses of the water permeation by using the Eyring equation indicated the tightening and loosening of the membrane packing upon the post- and the pre-modification, respectively.

    DOI: 10.11494/kisoyuki.2010.0.A26.0

    J-GLOBAL

    researchmap

  • 三元型フラーレン両親媒性分子から形成されるベシクルの合成と性質

    原野幸治, 本間達也, 水野慎一郎, 中村栄一

    高分子学会予稿集(CD-ROM)   60 ( 2 Disk1 )   2011

  • Surface Modification of Water-soluble Fluorous Fullerene Vesicle through Fluorous Interaction

    Mizuno Shinichiro, Homma Tatsuya, Harano Koji, Nakamura Eiichi

    Abstracts of Symposium on Physical Organic Chemistry   2010 ( 0 )   1P66 - 1P66   2011

     More details

    Language:Japanese   Publisher:The Society of Physical Organic Chemistry, Japan  

    The [60]fullerene pentadduct bearing perfluoroalkyl chains forms a stable bilayer vesicle in water and the perfluoroalkyl chains expose an aqueous phase. In this study, we found that the fullerene bilayer vesicle could be modified easily by using fluorous interaction between a fluorous environment of the fullerene vesicle surface and a fluorous tagged saccharide. Concretely, the mannose with a perfluorooctyl chain incorporated into the vesicle surface only by mixing these aqueous solutions. We revealed that the interaction between the vesicle and concanavalin A, which is a well studied lectin with a specific interaction with mannose, increased by the surface modification of the vesicle with mannose.

    DOI: 10.11494/kisoyuki.2010.0.1P66.0

    J-GLOBAL

    researchmap

  • 水溶性フルオラスフラーレンベシクルの固体表面上での特性および水溶液中の分子可溶化能

    本間達也, 原野幸治, 中村栄一, 中村栄一

    日本化学会講演予稿集   90th ( 3 )   2010

  • フラーレン二重膜ベシクルの調製後修飾:銅触媒Huisgen付加環化反応による表面官能基化

    南皓輔, 原野幸治, 中村栄一, 中村栄一

    日本化学会講演予稿集   90th ( 3 )   2010

  • 光修飾によるフラーレン二重膜ベシクルの膜透過性制御

    成田明光, 原野幸治, 中村栄一, 中村栄一

    日本化学会講演予稿集   90th ( 3 )   2010

  • フラーレン二重膜に対する水溶性有機分子の透過挙動

    西山枝里, 原野幸治, 中村栄一, 中村栄一

    日本化学会講演予稿集   90th ( 3 )   2010

  • 表面を疎水性修飾したフラーレン二重膜に対する水透過性の評価

    本間達也, 原野幸治, 磯部寛之, 中村栄一

    日本化学会バイオテクノロジー部会シンポジウム講演要旨集   13th   2010

  • 理学のキーワード : 第17回

    嶋作 一大, 原野 幸治, 浅井 祥仁, 小早川 高, 宮尾 祐介, 高木 征弘

    東京大学理学系研究科・理学部ニュース   40 ( 5 )   16 - 18   2009.1

     More details

    Language:Japanese   Publisher:東京大学大学院理学系研究科・理学部  

    「宇宙の夜明け:再電離」/「電子顕微鏡」/「ポジトロニウム」/「匂いの好き嫌い」/「セマンティック・ウェブ」/「惑星の気象」

    CiNii Books

    researchmap

  • Construction of fullerene bilayer vesicles bearing coumarin groups on the surface and their photoresponsibility

    成田明光, 原野幸治, 中村栄一

    日本化学会講演予稿集   89th ( 1 )   2009

  • Construction of Photoresponsive Fullerene Bilayer Vesicles and Property Modification by Photo-Cross-Linking

    Narita Akimitsu, Harano Koji, Nakamura Eiichi

    Abstracts of Papers: Host-Guest Chemistry Symposium   2009 ( 0 )   95 - 95   2009

     More details

    Language:Japanese   Publisher:Association of Research for Host-Guest and Supramolecular Chemistry  

    DOI: 10.14916/hgsupra.2009.0.95.0

    researchmap

  • Evaluation of permeability of organic solutes through fullerene bilayer

    Nishiyama Eri, Homma Tatsuya, Harano Koji, Nakamura Eiichi

    Abstracts of Papers: Host-Guest Chemistry Symposium   2009 ( 0 )   125 - 125   2009

     More details

    Language:Japanese   Publisher:Association of Research for Host-Guest and Supramolecular Chemistry  

    DOI: 10.14916/hgsupra.2009.0.125.0

    researchmap

  • Properties and Molecular Recognition Ability of Water-soluble Fullerene Vesicle with Fluorous Surface

    Homma Tatsuya, Harano Koji, Isobe Hiroyuki, Nakamura Eiichi

    Abstracts of Papers: Host-Guest Chemistry Symposium   2009 ( 0 )   117 - 117   2009

     More details

    Language:Japanese   Publisher:Association of Research for Host-Guest and Supramolecular Chemistry  

    DOI: 10.14916/hgsupra.2009.0.117.0

    researchmap

  • 高度にフッ素化された表面をもつ水溶性フラーレンナノ集合体の構造と性質

    本間達也, 原野幸治, 磯部寛之, 中村栄一, 中村栄一

    ナノ学会大会講演予稿集   7th   2009

  • Characterization and Properties of Water-soluble Fullerene Vesicles with a Fluorous Surface

    本間達也, 原野幸治, 磯部寛之, 中村栄一

    日本化学会講演予稿集   89th ( 1 )   2009

  • 光照射を用いないシリルケテンアセタールの[60]フラーレンへの五重付加反応

    中村優希, 毛利伸介, 原野幸治, 磯部寛之, 中村栄一

    日本化学会講演予稿集   88th ( 2 )   2008

  • 両親媒性フラーレンからなる二重膜ベシクルの表面化学修飾

    本間達也, 原野幸治, 磯部寛之, 中村栄一

    日本化学会講演予稿集   88th ( 1 )   2008

  • Formation of Discrete Water-soluble Nanocapsules Composed of Disk-shaped Amphiphilic Molecules

    NAKAMURA Takashi, HARANO Koji, HIRAOKA Shuichi, SHIRO Motoo, SHIONOYA Mitsuhiko

    Abstracts of Papers: Host-Guest Chemistry Symposium   2008 ( 0 )   52 - 52   2008

     More details

    Language:Japanese   Publisher:Association of Research for Host-Guest and Supramolecular Chemistry  

    DOI: 10.14916/hgsupra.2008.0.52.0

    researchmap

  • 選択的アニオン交換に基づくカプセル型六核錯体の内部空間の機能化

    清川円, 原野幸治, 平岡秀一, 平岡秀一, 塩谷光彦

    日本化学会講演予稿集   88th ( 2 )   2008

  • ディスク状両親媒性分子により形成される六量体ナノカプセルとその動的分子認識

    原野幸治, 平岡秀一, 平岡秀一, 城始勇, 塩谷光彦

    日本化学会講演予稿集   87th ( 2 )   2007

  • 外部刺激に応答して伸縮する配位高分子錯体

    原野 幸治

    化学と工業 = Chemistry and chemical industry   58 ( 5 )   593 - 593   2005.5

     More details

    Language:Japanese  

    CiNii Books

    researchmap

  • Multi-Component Self-Assembly: Quantitative Formation of a Molecular Cage from Two Kinds of Ligands

    利光史行, 平岡秀一, 原野幸治, 塩谷光彦

    日本化学会講演予稿集   85th ( 2 )   2005

  • 金属錯体型分子コンテナ:可逆な包接・放出を可能にする構造変換システム

    原野幸治, 平岡秀一, 城始勇, 塩谷光彦

    錯体化学討論会講演要旨集   54th   2004

▼display all

Industrial property rights

  • 化合物の特定形状の結晶及びその製造方法

    助川 潤平, 荒木 大悟, 鈴木 俊平, 巳浪 真輝, 尾内 拓馬, 脇田 文博, 劉 超, 中村 栄一, 原野 幸治

     More details

    Applicant:東和薬品株式会社, 国立大学法人 東京大学

    Application no:特願2024-093105  Date applied:2024.6

    Announcement no:特開2024-119912  Date announced:2024.9

    J-GLOBAL

    researchmap

  • 多分子膜、多分子膜の製造方法及び積層体

    中村 栄一, 原野 幸治, プリンス ラバット, 関根 良輔, 内田 光, 亀井 恒

     More details

    Applicant:国立大学法人 東京大学

    Application no:特願2021-105814  Date applied:2021.6

    Announcement no:特開2023-004241  Date announced:2023.1

    Patent/Registration no:特許第7799304号  Date registered:2026.1 

    J-GLOBAL

    researchmap

  • 多分子膜、多分子膜の製造方法及び積層体

    中村 栄一, 原野 幸治, プリンス ラバット, 関根 良輔, 内田 光, 亀井 恒

     More details

    Applicant:国立大学法人 東京大学

    Application no:特願2021-105814  Date applied:2021.6

    Announcement no:特開2023-004241  Date announced:2023.1

    J-GLOBAL

    researchmap

  • 化合物の特定形状の結晶及びその製造方法

    助川 潤平, 荒木 大悟, 鈴木 俊平, 巳浪 真輝, 尾内 拓馬, 脇田 文博, 劉 超, 中村 栄一, 原野 幸治

     More details

    Applicant:東和薬品株式会社, 国立大学法人 東京大学

    Application no:JP2019032722  Date applied:2019.8

    Patent/Registration no:特許第7506892号  Date registered:2024.6 

    J-GLOBAL

    researchmap

  • 化合物の特定形状の結晶及びその製造方法

    助川 潤平, 荒木 大悟, 鈴木 俊平, 巳浪 真輝, 尾内 拓馬, 脇田 文博, 劉 超, 中村 栄一, 原野 幸治

     More details

    Applicant:東和薬品株式会社, 国立大学法人 東京大学

    Application no:JP2019032722  Date applied:2019.8

    Publication no:WO2020-040233  Date published:2020.2

    J-GLOBAL

    researchmap

  • フラーレン化合物、半導体デバイス、太陽電池及び太陽電池モジュール

    中村 栄一, 武田 詠子, 原野 幸治, 荒牧 晋司

     More details

    Applicant:国立大学法人 東京大学, 三菱化学株式会社

    Application no:特願2015-098410  Date applied:2015.5

    Announcement no:特開2016-210750  Date announced:2016.12

    J-GLOBAL

    researchmap

  • 水分散性非晶質粒子及びその調製方法

    中村 栄一, 原野 幸治, 稲越 直人, 劉 超

     More details

    Applicant:国立大学法人 東京大学, 東和薬品株式会社

    Application no:JP2015056879  Date applied:2015.3

    Publication no:WO2015-137289  Date published:2015.9

    J-GLOBAL

    researchmap

  • フラーレン誘導体およびその製造方法

    中村 栄一, 磯部 寛之, 原野 幸治, 毛利 伸介, 中村 優希

     More details

    Applicant:国立大学法人 東京大学

    Application no:特願2008-029291  Date applied:2008.2

    Announcement no:特開2009-185000  Date announced:2009.8

    J-GLOBAL

    researchmap

▼display all

Awards

  • Nozoe Memorial Award for Young Organic Chemists

    2020.8   The Society of Physical Organic Chemistry, Japan   Electron Microscopic Study of Dynamic Processes of Organic Molecules and Their Assemblies

     More details

  • Encouragement Award

    2019.6   The Japanese Society of Microscopy   High-resolution microscopic imaging of organic molecules and molecular assemblies and its application for design of functional materials

    Harano Koji

     More details

  • The Young Scientists' Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

    2019.4   MEXT  

    Harano Koji

     More details

  • Thieme Chemistry Journals Award

    2019.1  

    Harano Koji

     More details

  • Chemist Award BCA

    2018.10   MSD Life Science Foundation   Functional Organic Chemistry Explored by High-Resolution Electron Microscopy

    Harano Koji

     More details

  • The 9th Kazato Research Encouragement Prize

    2016.2   Kazato Research Foundation  

    Harano Koji

     More details

  • 進歩賞

    2016.1   日本化学会  

    原野 幸治

     More details

  • 第25回井上研究奨励賞

    2009.2   井上科学振興財団  

    原野 幸治

     More details

  • BCSJ Award Article

    2021.2   The Chemical Society of Japan   Synthesis and Characterization of a Well-Defined Carbon Nanohorn-Supported Molybdenum Dioxo Catalyst by SMART-EM Imaging. Surface Structure at the Atomic Level

    Yosi Kratish, Takayuki Nakamuro, Yiqi Liu, Jiaqi Li, Issei Tomotsuka, Koji Harano, Eiichi Nakamura, Tobin J. Marks

     More details

  • BCSJ Award Article

    2020.9   The Chemical Society of Japan   Real-Time Video Imaging of Mechanical Motions of a Single Molecular Shuttle with Sub-Millisecond Sub-Angstrom Precision

    Toshiki Shimizu, Dominik Lungerich, Joshua Stuckner, Mitsuhiro Murayama, Koji Harano, Eiichi Nakamura

     More details

  • BCSJ Award

    2020.6   The Chemical Society of Japan   Spiro-conjugated Carbon/Heteroatom-bridged p-Phenylenevinylenes: Synthesis, Properties, and Microcrystal Electron Crystallographic Analysis of Racemic Solid Solutions

    H. Hamada, T. Nakamuro, K. Yamashita, H. Yanagisawa, O. Nureki, M. Kikkawa, K. Harano, R. Shang, E. Nakamura

     More details

  • CREST「分子技術」ライジング・スター賞

    2015.3   JST  

    原野 幸治

     More details

  • 第94春季年会優秀講演賞(学術)

    2014.5   日本化学会  

    原野 幸治

     More details

  • グローバルCOE 海外レクチャーシップ

    2012.2  

    原野 幸治

     More details

  • Tokyo Summer School on Frontier Chemistry 2005 ポスター賞

    2005.8  

    原野 幸治

     More details

  • 第85春季年会 学生講演賞

    2005.5   日本化学会  

    原野 幸治

     More details

  • 第54回錯体化学討論会 ポスター賞

    2004.9   錯体化学会  

    原野 幸治

     More details

▼display all

Research Projects

  • 透過電子顕微鏡の高速フォーカス制御に基づく原子分解能三次元構造解析

    Grant number:25K22209  2025.6 - 2027.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    原野 幸治

      More details

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    researchmap

  • Creation of unactivated C-H bond activation reactions by cooperative catalysis between metal nanoparticle and metal complex

    Grant number:25K01578  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Grant amount:\18720000 ( Direct Cost: \14400000 、 Indirect Cost:\4320000 )

    researchmap

  • Development of electron beam imaging method for single-molecule elemental and state analysis

    Grant number:24K01279  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    researchmap

  • 高選択なタンデム電解によるCO2を用いた有価物の直接合成法

    Grant number:23811314  2023.5 - 2026.3

    国立研究開発法人新エネルギー・産業技術総合開発機構  NEDO先導研究プログラム  エネルギー・環境新技術先導研究プログラム

      More details

    Authorship:Coinvestigator(s) 

    researchmap

  • Science of Meso-Hierarchy

    Grant number:23H04872  2023.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Transformative Research Areas (A)

      More details

    Grant amount:\140660000 ( Direct Cost: \108200000 、 Indirect Cost:\32460000 )

    researchmap

  • Cinematic Molecular Science of Meso-Hierarchy

    Grant number:23H04874  2023.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Transformative Research Areas (A)

      More details

    Grant amount:\161330000 ( Direct Cost: \124100000 、 Indirect Cost:\37230000 )

    researchmap

  • Bottom-up synthesis of intercalated two-dimensional materials based on aquatic molecular assembly

    Grant number:22H04521  2022.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

      More details

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    researchmap

  • Soft materials science based on structural two-dimensionality

    Grant number:21H05024  2021.7 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

      More details

    Grant amount:\181740000 ( Direct Cost: \139800000 、 Indirect Cost:\41940000 )

    researchmap

  • Comprehensive structure determination of carbon nanotubes

    Grant number:21H01758  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

      More details

    Grant amount:\16510000 ( Direct Cost: \12700000 、 Indirect Cost:\3810000 )

    researchmap

  • Application of ultrathin film of fullerenes as two-dimensional acquatic materials

    Grant number:20H05205  2020.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

      More details

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    researchmap

  • 超原子を基盤とする階層性ナノ物質科学の創成

    Grant number:20346980  2020 - 2026

    戦略的創造研究推進事業 CREST 

    佃 達哉, 中嶋 琢也, 原野 幸治

      More details

    Authorship:Coinvestigator(s) 

    本研究では、独自の精密化学合成・構造解析・理論計算の手法を総動員して、新しいナノ物質科学の学術基盤の構築を目指す。まず、多彩な構造因子を原子精度で規定した超原子群を創製し、基礎物性との相関を体系化する。次に、超原子分子の合成技術を開発し、その結合論・反応論・物性論を打ち立てる。さらに、超原子を次元性と対称性を制御しながら配列・集積化する技術を開発し、超原子の協同作用による新しい物性を探索する。

    researchmap

    J-GLOBAL

  • Molecular electron microscopy for dynamic studies on molecules and their assemblies

    Grant number:19H05459  2019.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Specially Promoted Research  Grant-in-Aid for Specially Promoted Research

      More details

    Grant amount:\617760000 ( Direct Cost: \475200000 、 Indirect Cost:\142560000 )

    researchmap

  • Structural analysis of nonperiodic intermediates in formation of coordination polymers

    Grant number:19H04563  2019.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

      More details

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    researchmap

  • Functional Self-Assembled Membranes with Structural Rigidity and Flexibility

    Grant number:17H03036  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Harano Koji

      More details

    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    In this study, we used conical amphiphilic fullerenes (CFAs) to create a molecular membrane that is neither too soft nor too hard, which is much more stable than small self-assembled membranes such as lipids, yet flexible enough to allow the introduction of various substituents. As a result, we found that CFA molecules are amphiphilic but have no interfacial activity and have a unique self-assembling behavior mediated by the strong association force between fullerenes. Based on this property, we have synthesized a variety of CFA molecules and succeeded in developing a molecular film that is extremely impermeable to water, a two-dimensional nanosheet with self-supporting nature and proton conductivity, and a nucleic acid transport system for cells based on micellar assembly of CFA.

    researchmap

  • Mechanistic Study on Formation of High-order Coordination Structures by Atomic-resolution Microscopic Movies

    Grant number:17H05355  2017.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

      More details

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    researchmap

  • Development of automated analysis for ultrafast molecular videos obtained by atomic resolution microscopy

    2016.10 - 2020.3

    JST 

      More details

    Authorship:Principal investigator 

    researchmap

    J-GLOBAL

  • Self-assembled free-standing organic nanosheets

    Grant number:16K13972  2016.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Harano Koji

      More details

    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    We found that a potassium salt of fullerene pentaadduct having alkyl side chain (R5C60K) forms a sphere having a spherical shape with a maximum diameter of 2 micrometers by dissolving it in organic solvent and gradually adding water. It was revealed that this sphere retains its shape even after drying subsequent to filtration and retains the internal water without loss. From this result, it was supported that the self-assembly formed from the pentasubstituted fullerenes has structural rigidity.

    researchmap

  • Hierarchal Control of Carbon Cluster Organization and Their Function

    Grant number:15H05754  2015.5 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)  Grant-in-Aid for Scientific Research (S)

    Nakamura Eiichi

      More details

    Grant amount:\164580000 ( Direct Cost: \126600000 、 Indirect Cost:\37980000 )

    Structure determination, design/synthesis of molecules, and space temporal control of molecular events represent the modern paradigm of organic chemistry. This project has focused on the hierarchal control of the solution and solid-state chemistry including time evolution of the structures of molecules and molecular assemblies. In doing so, we focused on the diverse functional activities of carbon cluster compounds possessing pi-conjugated systems, deepened our understanding of space temporal control, and developed biomedical and industrial applications. We have synthesized conical fullerene amphiphiles, and applied them for solubilization of nanoparticles, and for delivery of siRNA to kidney through a blood stream. We discovered that dissolution of tetrabenzoporphyrin in an organic acid results in precipitation of entangle fibers, a molecular wire showing a ON/OFF switching ratio of 2700.

    researchmap

  • Electron microscopic imaging of reaction and phase separation processes for molecules

    Grant number:26708016  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)  Grant-in-Aid for Young Scientists (A)

    Harano Koji

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\21190000 ( Direct Cost: \16300000 、 Indirect Cost:\4890000 )

    I established new techniques to analyze nano-level structure of organic materials and organic-inorganic composite using atomic-resolution transmission electron microscopy and high-resolution scanning electron microscopy. By the use of this technology, we revealed chemical processes of self-assembly such as formation of metal-organic hybrid vesicles and polymer-vesicle composites, at single molecule level. In addition to that, we succeeded in designing functions of self-organizing functional materials such as drug transport carriers and hybrid catalysts based on the knowledge obtained by the high-resolution microscopic analyses.

    researchmap

  • Morphology control of organic crystals by single-molecule template method

    Grant number:25620025  2013.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    HARANO Koji

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3250000 ( Direct Cost: \2500000 、 Indirect Cost:\750000 )

    The aim of this research is to control crystal structure and morphology by chemical design. We thus demonstrated the concept of controlled nucleation on functionalized surfaces to the examination on how the PEDOT:PSS, a commonly-used buffer material, interacts with the neighboring layer of p-type organic semiconductors in an organic photovoltaic device. SEM analysis of crystals and aggregates of organic donor compounds showed that PEDOT:PSS effectively nucleates the crystallization of the donor material on its surface to form a uniformly thick film with polycrystalline nature. In contrast, a graphitic surface cannot induce structural order of the donor molecules when coated onto it. This study demonstrates that interaction at the organic-organic interface dominates the nucleation and the growth of phase-separated structure in thin-film devices.

    researchmap

  • 遺伝子・薬剤キャリアとして機能する自己集合型プログラマブルナノスフィアの創製

    Grant number:24108710  2012.4 - 2014.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    原野 幸治

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    本研究では低ダメージの遺伝子導入および薬剤の標的選択的輸送に資する水溶性プログラマブルナノスフィアの構築とその機能評価を行った.以下に本年度に得られた結果を示す.(1)水溶性アミノフラーレンを用いた肺選択的siRNA輸送:アミノフラーレンTPFEから形成される自己集合型ナノ粒子を基盤とした生体内における階層的自己集合を利用し,肺選択的にsiRNAを輸送するシステムを構築することに成功した.静脈内に投与されたTPFE-siRNAは血清タンパクとの相互作用により粒子径がμmサイズまで速やかに増大し,他の臓器に比べ細い肺の毛細血管に選択的に蓄積したのち,TPFE-siRNA会合体へと再び解離し細胞内へと取りこまれる.このため,TPFEが時間経過とともに肺から除去されるため,ダメージの小さい効果的な肺選択的が達成される.低毒性の薬剤輸送システムへの応用が期待される.(2)フラーレン二重膜ベシクルの光応答性:水溶性五重付加型フラーレンから形成するフラーレン二重膜ベシクルへの光照射によりその性質を変化させることに成功した.フェニル五置換フラーレンからなるベシクルへの紫外光照射によりフラーレン部位同士が共有結合的にクロスリンクされ,二重膜に対する水透過性が減少することを見いだした.一方で,表面にヒドロキシクマリン部位を呈示したフラーレンベシクルは融合性を示すが,光照射による二量化反応を行う事で融合挙動が抑制された.(3)フラーレン二重膜ベシクルによる難溶性分子の可溶化:フラーレン二重膜ベシクルの膜内部への疎水性分子結合能を評価したところ,脂質二重膜に比べてより多くの疎水性分子を取り込めることが明らかとなった.また,フラーレン部位への可溶化については芳香族化合物に対して顕著な選択性を示した.これらの結果から,フラーレンベシクルが水に難溶性の薬剤に対する有用なキャリアであることが示された.

    researchmap

  • Fabrication of High-Efficiency Organic Photovoltaic Devices by Control of Molecular Orientation on Chemically-Modified Graphene

    Grant number:23655116  2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    HARANO Koji

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    Development of high-efficiency solar cells is one of the most important challenges in science as energy source for the next generation. We succeeded in induction of nanocolumnar morphology of tetrabenzoporphyrin, an organic semiconductor, on a polymer substrate coated with a solution-processed graphitic material having one-atom thickness. Dispersed graphitic flakes enabled us to form uniformly dispersed nanocolumnar structure, which can be utilized for increasing current density in organic photovoltaic devices.

    researchmap

  • Structure and dynamic behavior analysis of single molecules supported on chemically-modified graphene sheets

    Grant number:21750136  2009 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    HARANO Koji

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    Utilizing "transparency" of graphitic sheets consisting of single-walled carbon nanotube, single-walled carbon nanohorn and graphene in TEM analysis, we observed nanoscopic behavior of single organic molecules on chemically modified graphene sheets. This methodology provided us unprecedented information on structure and dynamic behavior of substances at molecular level, such as semistatistic conformational analysis of single alkyl and perfluoroalkyl chains, and structural elucidation of embryos in crystal growth process.

    researchmap

  • ディスク状多座配位子を用いた金属イオンの三次元集積化および機能性金属錯体の構築

    Grant number:04J11506  2004 - 2006

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    原野 幸治

      More details

    Grant amount:\2800000 ( Direct Cost: \2800000 )

    前年度までに、3-ピリジル基を有するディスク状三座配位子(L)と10種類の二価金属イオンから直径約3.5nmのカプセル錯体が定量的に自己集合することを明らかにしている。カプセル錯体の対アニオンはカプセル内外に同数分布しているが、より配位能の強いアニオンを添加することにより、カプセル内部の対アニオンを定量的かっ選択的に置換できることを今回新たに見いだした。特に、ピリジル基やフェロセニル基など、分子認識能や酸化還元能を有するアニオンを用いた場合においても選択的に置換されることを利用し、カプセル内面を機能性官能基により簡便に修飾できる。今後、カプセル錯体の機能化された内部空間を特異的分子認識場や物質変換場として活用できると期待される。
    また、本研究においてこれまで見いだされた種々の自己集合型ナノカプセル錯体におけるカプセル内外の分子・イオンの交換速度を、EXSY NMRや線型解析をはじめとする動的NMRの手法を用いて解析した。その結果、カプセル錯体内外の分子交換速度はナノカプセルの三次元構造や金属イオンの種類、または溶媒によって大きく変化することが示唆された。特に、上述の人面体型カプセル錯体においては、対アニオンは配位子が完全に解離せずとも交換可能であることが明らかとなった。これらの知見は、カプセル分子による分子認識の選択性発現や内部空間を利用した反応設計に向けた重要な指針となる。
    これらの金属錯体型ナノカプセルに加えて、前年度までに見いだされた、配位子L単独で形成する自己会合型六量体ナノカプセルについてもその機能性を検討した。Lは元来蛍光性の分子であるが、カプセル形成によりその蛍光強度が著しく増大することが明らかとなった。また、この六量体カプセルは酸の添加により速やかに単量体へと解離することを利用し、酸・塩基によりゲスト分子の可逆的な包接・放出をコントロール可能な動的分子認識系の構築に成功した。

    researchmap

▼display all

Teaching Experience

  • 有機化学1

    2015 - 2021 Institution:東京大学

     More details

  • Frontier Science from the Viewpoint of "Hot Water in Tea Cup"

    2015 - 2020 Institution:The University of Tokyo

     More details

  • Organic Chemistry 2

    2008 - 2016 Institution:The University of Tokyo

     More details

  • 有機化学実験

    2007 - 2021 Institution:東京大学

     More details

  • 有機化学演習

    2007 - 2018 Institution:東京大学

     More details