Organization
Institute of Integrated Research Laboratory for Chemistry and Life Science Assistant Professor
Title
Assistant Professor
External link
KAWATANI MINORU
Research Interests
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Fluorescence imaging
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Raman probe
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Raman imaging
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Fluorescent probe
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Zirconium-89
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RI theranostics
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Caged compounds
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Actinium-225
Papers
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Shun-suke Kanai, Hiroyoshi Fujioka, Minoru Kawatani, Spencer John Spratt, Shun-suke Fukuta, Zhihao Zhan, Yang Ma, Kazuhiro Kuruma, Daisuke Asanuma, Yuichi Asada, Masayasu Taki, Shigehiro Yamaguchi, Yasuyuki Ozeki, Mako Kamiya
Communications Chemistry 2026.4
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Enzyme activity as an actionable axis for small-molecule precision oncology
Kyohhei Fujita, Mako Kamiya, Shingo Dan, Ryo Tachibana, Minoru Kawatani, Ryosuke Kojima, Rumi Hino, Kimihiko Kobayashi, Shotaro Inoue, Miyuki Tani, Yuko Hirata, Shun Kawashima, Kanami Yamazaki, Yumiko Nishimura, Yoshimi Ohashi, Sho Isoyama, Akihiro Nakada, Nobuyoshi Matsumoto, Yuji Ikegaya, Jun Nakajima, Yasuteru Urano
2026.4
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Functional Raman Probes for Detecting Enzyme Activities Based on Aggregation Control
Momoko Okinaka, Minoru Kawatani, Hiroyoshi Fujioka, Spencer John Spratt, Hiroki Ito, Yoshihiro Misawa, Reika Otake, Aoi Ishikawa, Ryosuke Kojima, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
Analytical Chemistry 2025.9
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Near-Infrared Coumarin-Hemicyanine Hybrid Dyes Bearing an Intramolecular Nucleophile for Activatable Fluorescence and Raman Imaging
Hiroyoshi Fujioka, Ryo Sakamoto, Kotaro Hiramatsu, Yusuke Murakami, Minori Masaki, Minoru Kawatani, Satoshi Matsumoto, Ryosuke Kojima, Yasuteru Urano, Hideaki Kano, Mako Kamiya
Analytical Chemistry 2025.8
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Cyano-Hydrol green derivatives: Expanding the 9-cyanopyronin-based resonance Raman vibrational palette Reviewed
Hiroyoshi Fujioka, Yuta Murao, Momoko Okinaka, Spencer John Spratt, Jingwen Shou, Minoru Kawatani, Ryosuke Kojima, Ryo Tachibana, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
Bioorganic & Medicinal Chemistry Letters 106 129757 - 129757 2024.4
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Development of optical probes with excellent intracellular retention
Minoru Kawatani, Mako Kamiya, Yasuteru Urano
Folia Pharmacologica Japonica 159 ( 1 ) 18 - 24 2024.1
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Yugo Kuriki, Mari Sogawa, Toru Komatsu, Minoru Kawatani, Hiroyoshi Fujioka, Kyohhei Fujita, Tasuku Ueno, Kenjiro Hanaoka, Ryosuke Kojima, Rumi Hino, Hiroki Ueo, Hiroaki Ueo, Mako Kamiya, Yasuteru Urano
Journal of the American Chemical Society 2023.12
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Super-resolution vibrational imaging based on photoswitchable Raman probe Reviewed
Jingwen Shou, Ayumi Komazawa, Yuusaku Wachi, Minoru Kawatani, Hiroyoshi Fujioka, Spencer John Spratt, Takaha Mizuguchi, Kenichi Oguchi, Hikaru Akaboshi, Fumiaki Obata, Ryo Tachibana, Shun Yasunaga, Yoshio Mita, Yoshihiro Misawa, Ryosuke Kojima, Yasuteru Urano, Mako Kamiya, Yasuyuki Ozeki
Science Advances 2023.6
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Activatable Raman Probes Utilizing Enzyme-Induced Aggregate Formation for Selective Ex Vivo Imaging Reviewed
Hiroyoshi Fujioka, Minoru Kawatani, Spencer John Spratt, Ayumi Komazawa, Yoshihiro Misawa, Jingwen Shou, Takaha Mizuguchi, Hina Kosakamoto, Ryosuke Kojima, Yasuteru Urano, Fumiaki Obata, Yasuyuki Ozeki, Mako Kamiya
Journal of the American Chemical Society 145 ( 16 ) 8871 - 8881 2023.4
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9‐Cyano‐10‐telluriumpyronin Derivatives as Red‐light‐activatable Raman Probes Reviewed
Minoru Kawatani, Spencer J. Spratt, Hiroyoshi Fujioka, Jingwen Shou, Yoshihiro Misawa, Ryosuke Kojima, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
Chemistry – An Asian Journal 2023.1
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Fluorescence Probes for Imaging Basic Carboxypeptidase Activity in Living Cells with High Intracellular Retention Reviewed
Hirohisa Iwaki, Mako Kamiya, Minoru Kawatani, Ryosuke Kojima, Tatsuya Yamasoba, Yasuteru Urano
Analytical Chemistry 93 ( 7 ) 3470 - 3476 2021.2
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Neural and behavioral control in Caenorhabditis elegans by a yellow-light–activatable caged compound Reviewed
Hironori Takahashi, Mako Kamiya, Minoru Kawatani, Keitaro Umezawa, Yoshiaki Ukita, Shinsuke Niwa, Toshiyuki Oda, Yasuteru Urano
Proceedings of the National Academy of Sciences 118 ( 6 ) 2021.2
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Prostate-Specific Membrane Antigenのカルボキシペプチダーゼ活性を利用した前立腺がんの蛍光検出
山田 大介, 河谷 稔, 山本 恭子, 神谷 真子, 宮川 仁平, 美山 優, 小嶋 良輔, 森川 鉄平, 佐藤 悠佑, 川合 剛人, 鈴木 基文, 浦野 泰照, 久米 春喜
日本泌尿器科学会総会 108回 847 - 847 2020.12
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Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity Reviewed
Minoru Kawatani, Kyoko Yamamoto, Daisuke Yamada, Mako Kamiya, Jimpei Miyakawa, Yu Miyama, Ryosuke Kojima, Teppei Morikawa, Haruki Kume, Yasuteru Urano
Journal of the American Chemical Society 141 ( 26 ) 10409 - 10416 2019.7
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Factors affecting the uncaging efficiency of 500 nm light-activatable BODIPY caging group Reviewed
Minoru Kawatani, Mako Kamiya, Hironori Takahashi, Yasuteru Urano
Bioorganic & Medicinal Chemistry Letters 28 ( 1 ) 1 - 5 2018.1
Presentations
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カルボキシペプチダーゼ活性を可視化するイメージングプローブ
河谷 稔, 沖中 桃子, 出口 海斗, 浦野 泰照, 小関 泰之, 神谷 真子
日本化学会第106春季年会 2026.3
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Development of Aggregation-based Raman Probes for Enzyme Activity Detection
Minoru Kawatani, Momoko Okinaka, Hiroyoshi Fujioka, Spencer J. Spra, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiy
Pacifichem 2025 2025.12
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Development of fluorescence and Raman probes for visualizing enzyme activities in living cells Invited
Minoru Kawatani
AIMECS2025 2025.9
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Development of Raman probes detecting enzyme activities based on aggregation control
Minoru Kawatani, Momoko Okinaka, Hiroyoshi Fujioka, Spencer Spra, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
2025.6
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信号を光で制御可能なラマンプローブの開発
河谷 稔, 駒沢 歩弥, Shou Jingwen, 藤岡 礼任, 三田 吉郎, 浦野 泰照, 小関 泰之, 神谷 真子
第40回メディシナルケミストリーシンポジウム 2023.11
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Development of photoactivatable and photoswitchable Raman probes
Minoru KAWATANI, Ayumi KOMAZAWA, Jingwei SHO, Hiroyoshi FUJIOKA, Yoshio MITA, Yasuteru URAN, Yasuyuki OZEKI, Mako, KAMIYA
2023.11
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光応答性ラマンプローブの開発と超解像ラマンイメージングへの応用
河谷 稔, 駒沢 歩弥, Shou Jingwen, 藤岡 礼任, 三田 吉郎, 浦野 泰照, 小関 泰之, 神谷 真子
日本薬学会第144年会 2024.3
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Development of red-light-activatable / photoswitchable Raman probes for super-resolution Raman imaging
Minoru Kawatani, Ayumi Komazawa, Jingwen Shou, Hiroyoshi Fujioka, Yoshio Mita, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
ISBC2024 2024.4
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DEVELOPMENT OF RAMAN PROBES TO DETECT ENZYME ACTIVITIES BY AGGREGATION CONTROL
Minoru Kawatani, Momoko Okinaka, Spencer Spra, Hiroyoshi Fujioka, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya
EFMC-ISCB 2025 2025.1
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凝集体形成を活用した新規酵素活性検出ラマンプローブの開発
河谷稔, 沖中桃子, Spratt Spencer, 藤岡礼任, 浦野泰照, 小関泰之, 神谷真子
日本薬学会第145年会 2025.3
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ProTide 化学を応用したモジュール型分子設計法によるカルボキシペプチダーゼ活性検出蛍光プローブの開発
河谷稔, 栗木優五, 曽川マリー, 小松徹, 藤岡礼任, 藤田恭平, 上野匡, 神谷真子, 浦野泰照
第18回 ケミカルバイオロジー学会 2024.5
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凝集性制御に基づく加水分解酵素活性検出ラマンプローブの開発
河谷稔, 沖中桃子, Spratt Spencer, 藤岡礼任, 浦野泰照, 小関泰之, 神谷真子
第18回バイオ関連化学シンポジウム 2024.9
Research Projects
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2023 - 2025
科学技術振興機構 戦略的な研究開発の推進 戦略的創造研究推進事業 ACT-X
河谷 稔
Authorship：Principal investigator
蛍光タンパク質を用いた生体分子イメージングでは、幅広い蛍光スペクトルの重なりが原因で同時観察可能な色数が限られるという課題があります。本研究ではラマンスペクトルの狭帯域性に着目し、蛍光よりも同時多重検出能に優れたラマンイメージング法での観察に適した多色の「ラマンタンパク質」を独自の分子設計によって開発し、多様な生命現象を同時観察する基盤技術の確立を目指します。