Nanotechnology/Materials / Nanobioscience

Nanotechnology/Materials / Nanomaterials

Life Science / Biomaterials

Life Science / Biomedical engineering

Osaka Prefecture University   School of Engineering

- 1999

The Chemical Society of Japan

The Society of Polymer Science

The Japanese Biochemical Society

堺市大規模小売店舗立地審議会   委員  

2016.6 - 2023.5   

高分子学会   「高分子」編集委員  

2016.6 - 2018.5   

近畿化学協会   代議員  

2016.4   

日本バイオマテリアル学会   評議員  

2015.11   

特別研究員等審査会   専門委員  

科学研究費委員会   専門委員  

Structural Optimization of Carboxy-Terminal Phenylalanine-Modified Dendrimers for T-Cell Association and Model Drug Loading Reviewed

Hiroya Shiba, Tomoka Hirose, Akinobu Sakai, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima

Pharmaceutics   16 ( 6 )   715 - 715   2024.5

Preparation and Characterization of Acrylic and Methacrylic Phospholipid-Mimetic Polymer Hydrogels and Their Applications in Optical Tissue Clearing

Nanako Dei, Kazuhiko Ishihara, Akikazu Matsumoto, Chie Kojima

Polymers   16 ( 2 )   241 - 241   2024.1

Gene Delivery into T cells using Ternary Complexes of DNA, Lipofectamine, and Carboxy-terminal Phenylalanine-modified Dendrimers Reviewed

Chie Kojima, Mei Sawada, Ikuhiko Nakase, Akikazu Matsumoto

Macromolecular Bioscience   e2300139   2023.11

In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model

Shunichi Watanabe, Ayaka Takagi, Eiji Yuba, Chie Kojima, Nanako Dei, Akikazu Matsumoto, Jun Tanikawa, Tetsuya Kawamura, Nadeeka H. De Silva, Takeshi Izawa, Takashi Akazawa, Ryoji Kanegi, Shingo Hatoya, Toshio Inaba, Kikuya Sugiura

The FASEB Journal   37 ( 11 )   2023.10

T-cell association of carboxy-terminal dendrimers with different bound numbers of phenylalanine and their application to drug delivery Reviewed

Hiroya Shiba, Tomoka Hirose, Yunshen Fu, Masataka Michigami, Ikuo Fujii, Ikuhiko Nakase, Akikazu Matusmoto, Chie Kojima

Pharmaceutics   15 ( 3 )   888   2023.3

Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy

Chie Kojima, Yasuhito Suzuki, Yuka Ikemoto, Masaru Tanaka, Akikazu Matsumoto

POLYMER JOURNAL   55 ( 1 )   63 - 73   2023.1

Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells. International journal

Hiroya Shiba, Misaki Nishio, Mei Sawada, Mamiko Tamaki, Masataka Michigami, Shinya Nakai, Ikuhiko Nakase, Ikuo Fujii, Akikazu Matsumoto, Chie Kojima

Journal of materials chemistry. B   10 ( 14 )   2463 - 2470   2022.4

RAFT Polymerization of 2-(tert-Butoxycarbonyloxy)Ethyl Methacrylate and Transformation to Functional Polymers via Deprotection and the Subsequent Polymer Reactions

Chu Jing, Kaito Osada, Chie Kojima, Yasuhito Suzuki, Akikazu Matsumoto

MACROMOLECULAR CHEMISTRY AND PHYSICS   223 ( 1 )   2022.1

Solubilization of paclitaxel by self-assembled amphiphilic phospholipid-mimetic polymers with varied hydrophobicity

Chie Kojima, Tomoka Hirose, Risa Katayama, Akikazu Matsumoto

Polymers   13 ( 16 )   2021.8

Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density. International journal

Ayako Tsujimoto, Hiroki Uehara, Haruna Yoshida, Misaki Nishio, Kousuke Furuta, Takashi Inui, Akikazu Matsumoto, Shigeaki Morita, Masaru Tanaka, Chie Kojima

Materials science & engineering. C, Materials for biological applications   126   112159 - 112159   2021.7

Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging. International journal

Chie Kojima, Takayuki Koda, Tetsuro Nariai, Junji Ichihara, Kikuya Sugiura, Akikazu Matsumoto

Macromolecular bioscience   e2100170   2021.6

Preparation of a visible light-responsive gold nanoparticle-containing collagen gel microarray for in situ cell separation

Chie Kojima, Yusuke Nakajima, Takeshi Kawano, Kenji Takatsuka

Research on Chemical Intermediates   47 ( 1 )   51 - 60   2021.1

Singlet oxygen generation by sonication using a water-soluble fullerene (C<inf>60</inf>) complex: a potential application for sonodynamic therapy

Thi Lien Nguyen, Risa Katayama, Chie Kojima, Akikazu Matsumoto, Kazuhiko Ishihara, Shin ichi Yusa

Polymer Journal   52 ( 12 )   1387 - 1394   2020.12

Different antifouling effects of random and block copolymers comprising 2-methacryloyloxyethyl phosphorylcholine and dodecyl methacrylate

Chie Kojima, Risa Katayama, Thi Lien Nguyen, Yuto Oki, Ayako Tsujimoto, Shin ichi Yusa, Kohei Shiraishi, Akikazu Matsumoto

European Polymer Journal   136   2020.8

Different antifouling effects of random and block copolymers comprising 2-methacryloyloxyethyl phosphorylcholine and dodecyl methacrylate

Chie Kojima, Risa Katayama, Thi Lien Nguyen, Yuto Oki, Ayako Tsujimoto, Shin-ichi Yusa, Kohei Shiraishi, Akikazu Matsumoto

EUROPEAN POLYMER JOURNAL   136   2020.8

Association of hydrophobic carboxyl-terminal dendrimers with lymph node-resident lymphocytes

Yutaka Nishimoto, Misaki Nishio, Shu Nagashima, Kohei Nakajima, Takayuki Ohira, Shinya Nakai, Ikuhiko Nakase, Kei Higashikawa, Yuji Kuge, Akikazu Matsumoto, Mikako Ogawa, Chie Kojima

Polymers   12 ( 7 )   1 - 10   2020.7

Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes

Yutaka Nishimoto, Misaki Nishio, Shu Nagashima, Kohei Nakajima, Takayuki Ohira, Shinya Nakai, Ikuhiko Nakase, Kei Higashikawa, Yuji Kuge, Akikazu Matsumoto, Mikako Ogawa, Chie Kojima

POLYMERS   12 ( 7 )   2020.7

Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods

Risa Katayama, Nobuyuki Tanaka, Yusuke Takagi, Kohei Shiraishi, Yo Tanaka, Akikazu Matsumoto, Chie Kojima

Langmuir   36 ( 20 )   5626 - 5632   2020.5

Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods

Risa Katayama, Nobuyuki Tanaka, Yusuke Takagi, Kohei Shiraishi, Yo Tanaka, Akikazu Matsumoto, Chie Kojima

LANGMUIR   36 ( 20 )   5626 - 5632   2020.5

Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. International journal

Yutaka Nishimoto, Shu Nagashima, Kohei Nakajima, Takayuki Ohira, Tatsumi Sato, Takeshi Izawa, Jyoji Yamate, Kei Higashikawa, Yuji Kuge, Mikako Ogawa, Chie Kojima

International journal of pharmaceutics   576   119021 - 119021   2020.2

Rapid photoinduced single cell detachment from gold nanoparticle-embedded collagen gels with low denaturation temperature

Chie Kojima, Misaki Nishio, Yusuke Nakajima, Takeshi Kawano, Kenji Takatsuka, Akikazu Matsumoto

Polymers   12 ( 1 )   2020.1

Rapid Photoinduced Single Cell Detachment from Gold Nanoparticle-Embedded Collagen Gels with Low Denaturation Temperature

Chie Kojima, Misaki Nishio, Yusuke Nakajima, Takeshi Kawano, Kenji Takatsuka, Akikazu Matsumoto

POLYMERS   12 ( 1 )   2020.1

One-Shot Preparation of Polyacrylamide/Poly(sodium styrenesulfonate) Double-Network Hydrogels for Rapid Optical Tissue Clearing

Takayuki Koda, Shunsuke Dohi, Hedeki Tachi, Yasuhito Suzuki, Chie Kojima, Akikazu Matsumoto

ACS Omega   4 ( 25 )   21083 - 21090   2019.12

Rapid optical tissue clearing using various anionic polymer hydrogels

Chie Kojima, Yuta Ono, Takayuki Koda, Akikazu Matsumoto

MATERIALS TODAY COMMUNICATIONS   21   2019.12

One-Shot Preparation of Polyacrylamide/Poly(sodium styrenesulfonate) Double-Network Hydrogels for Rapid Optical Tissue Clearing

Takayuki Koda, Shunsuke Dohi, Hedeki Tachi, Yasuhito Suzuki, Chie Kojima, Akikazu Matsumoto

ACS OMEGA   4 ( 25 )   21083 - 21090   2019.12

Rapid optical tissue clearing using poly(acrylamide-co-styrenesulfonate) hydrogels for three-dimensional imaging

Yuta Ono, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima

Journal of Biomedical Materials Research - Part B Applied Biomaterials   107 ( 7 )   2297 - 2304   2019.10

Rapid optical tissue clearing using poly(acrylamide-co-styrenesulfonate) hydrogels for three-dimensional imaging

Yuta Ono, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS   107 ( 7 )   2297 - 2304   2019.10

Formation of Hydrophobic Domains on the poly(MPC- co-Dodecyl Methacrylate)-Coated Surface Recognized by Macrophage-like Cells

Risa Katayama, Musashi Ikeda, Kohei Shiraishi, Akikazu Matsumoto, Chie Kojima

Langmuir   35 ( 37 )   12229 - 12235   2019.9

Formation of Hydrophobic Domains on the poly(MPC-co-Dodecyl Methacrylate)-Coated Surface Recognized by Macrophage-like Cells

Risa Katayama, Musashi Ikeda, Kohei Shiraishi, Akikazu Matsumoto, Chie Kojima

LANGMUIR   35 ( 37 )   12229 - 12235   2019.9

Design of peptide–dendrimer conjugates with tumor homing and antitumor effects Reviewed

Chie Kojima, Ken Saito, Eisaku Kondo

Research on Chemical Intermediates   44 ( 8 )   1 - 11   2018.1

Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors Reviewed

Ken Saito, Hidekazu Iioka, Chie Kojima, Mikako Ogawa, Eisaku Kondo

CANCER SCIENCE   107 ( 9 )   1290 - 1301   2016.9

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity. Reviewed

Kim JY, Kinoshita M, Kume S, Gt H, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH

The Biochemical journal   473 ( 21 )   3837 - 3854   2016.8

Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group Reviewed

Yuichiro Niki, Mikako Ogawa, Rie Makiura, Yasuhiro Magata, Chie Kojima

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE   11 ( 8 )   2119 - 2127   2015.11

Physicochemical nature of interfaces controlling ferredoxin NADP(+) reductase activity through its interprotein interactions with ferredoxin. Reviewed

Kinoshita M, Kim JY, Kume S, Sakakibara Y, Sugiki T, Kojima C, Kurisu G, Ikegami T, Hase T, Kimata-Ariga Y, Lee YH

Biochimica et biophysica acta   1847 ( 10 )   1200 - 1211   2015.10

Dual stimuli-sensitive dendrimers: Photothermogenic gold nanoparticle-loaded thermo-responsive elastin-mimetic dendrimers Reviewed

Daichi Fukushima, Ugir Hossain Sk, Yasuhiro Sakamoto, Ikuhiko Nakase, Chie Kojima

COLLOIDS AND SURFACES B-BIOINTERFACES   132   155 - 160   2015.8

(1)H, (15)N and (13)C resonance assignments of the conserved region in the middle domain of S. pombe Sin1 protein. Reviewed

Kataoka S, Furuita K, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C

Biomolecular NMR assignments   9 ( 1 )   89 - 92   2015.4

Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints. Reviewed

Furuita K, Kataoka S, Sugiki T, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C

Journal of biomolecular NMR   61 ( 1 )   55 - 64   2015.1

Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging Reviewed

Chie Kojima, Yuichiro Niki, Mikako Ogawa, Yasuhiro Magata

INTERNATIONAL JOURNAL OF PHARMACEUTICS   476 ( 1-2 )   164 - 168   2014.12

The synthesis and evaluation of polymer prodrug/collagen hybrid gels for delivery into metastatic cancer cells Reviewed

Chie Kojima, Eiko Nishisaka, Tomoyuki Suehiro, Kenji Watanabe, Atsushi Harada, Tatsushi Goto, Yasuhiro Magata, Kenji Kono

Nanomedicine: Nanotechnology, Biology, and Medicine   9 ( 6 )   767 - 775   2013.8

Doxorubicin-conjugated dendrimer/collagen hybrid gels for metastasis-associated drug delivery systems. Reviewed International journal

Kojima C, Suehiro T, Watanabe K, Ogawa M, Fukuhara A, Nishisaka E, Harada A, Kono K, Inui T, Magata Y

Acta biomaterialia   9 ( 3 )   5673 - 5680   2013.3

Synthesis and binding properties of peptidomimetics based on a dendritic polymer Reviewed

Chie Kojima, Harumi Fukada, Takashi Inui

Polymer Journal   45 ( 3 )   339 - 345   2013.3

Utilization of lysine ¹³C-methylation NMR for protein-protein interaction studies. Reviewed

Hattori Y, Furuita K, Ohki I, Ikegami T, Fukada H, Shirakawa M, Fujiwara T, Kojima C

Journal of biomolecular NMR   55 ( 1 )   19 - 31   2013.1

Design of a novel drug carrier with photoresponsive properties: Drug-encapsulated and alkanethiol-modified gold-nanoparticle-loaded PEGylated dendrimer Reviewed

Kojima C, Kawabata H, Harada A, Horinaka H, Kono K

Chemistry Letters   42 ( 6 )   612 - 614   2013

Polyamidoamine Dendron-Bearing Lipids as a Nonviral Vector: Influence of Dendron Generation Reviewed

Kenji Kono, Ryuji Ikeda, Kota Tsukamoto, Eiji Yuba, Chie Kojima, Atsushi Harada

BIOCONJUGATE CHEMISTRY   23 ( 4 )   871 - 879   2012.4

Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids Reviewed

Yuba E, Nakajima Y, Tsukamoto K, Iwashita S, Kojima C, Harada A, Kono K

Journal of Controlled Release   160 ( 3 )   552 - 560   2012

Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics Reviewed

Chie Kojima, Baris Turkbey, Mikako Ogawa, Marcelino Bernardo, Celeste A. S. Regino, L. Henry Bryant, Peter L. Choyke, Kenji Kono, Hisataka Kobayashi

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE   7 ( 6 )   1001 - 1008   2011.12

Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy Reviewed

Kenji Kono, Seiji Nakashima, Daisuke Kokuryo, Ichio Aoki, Hiroaki Shimomoto, Sadahito Aoshima, Kazuo Maruyama, Eiji Yuba, Chie Kojima, Atsushi Harada, Yukihito Ishizaka

BIOMATERIALS   32 ( 5 )   1387 - 1395   2011.2

Thermosensitive Molecular Assemblies from Poly(amidoamine) Dendron-Based Lipids Reviewed

Kenji Kono, Etsuo Murakami, Yuki Hiranaka, Eiji Yuba, Chie Kojima, Atsushi Harada, Kazuo Sakurai

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   50 ( 28 )   6332 - 6336   2011

Effect of Enzyme Modification by Well-Defined Multi-Armed Poly(Ethylene Glycol) Synthesized Using Polyamidoamine Dendron

Atsushi Harada, Takeshi Kato, Akifumi Kawamura, Chie Kojima, Kenji Kono

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   22 ( 12 )   1551 - 1561   2011

Preparation of near-infrared light absorbing gold nanoparticles using polyethylene glycol-attached dendrimers Reviewed

Chie Kojima, Yasuhito Umeda, Atsushi Harada, Kenji Kono

COLLOIDS AND SURFACES B-BIOINTERFACES   81 ( 2 )   648 - 651   2010.12

Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy. Reviewed

Kono K, Ozawa T, Yoshida T, Ozaki F, Ishizaka Y, Maruyama K, Kojima C, Harada A, Aoshima S

Biomaterials   31   7096 - 7105   2010.9

PEG-attached PAMAM dendrimers encapsulating gold nanoparticles: Growing gold nanoparticles in the dendrimers for improvement of their photothermal properties Reviewed

Yasuhito Umeda, Chie Kojima, Atsushi Harada, Hiromichi Horinaka, Kenji Kono

Bioconjugate Chemistry   21 ( 8 )   1559 - 1564   2010.8

Higher Order Structure of Short Collagen Model Peptides Attached to Dendrimers and Linear Polymers Reviewed

Tomoyuki Suehiro, Chie Kojima, Sayako Tsumura, Atsushi Harada, Kenji Kono

BIOPOLYMERS   93 ( 7 )   640 - 648   2010.7

X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer Reviewed

Chie Kojima, Yasuhito Umeda, Mikako Ogawa, Atsushi Harada, Yasuhiro Magata, Kenji Kono

NANOTECHNOLOGY   21 ( 24 )   245104   2010.6

Effective Tolerance to Serum Proteins of Head Tail Type Polycation Vectors by PEGylation at the Periphery of the Head Block Reviewed

Atsushi Harada, Yuka Kimura, Chie Kojima, Kenji Kono

BIOMACROMOLECULES   11 ( 4 )   1036 - 1042   2010.4

Effect of pH and Generation of Dendron on Single-Step Synthesis of Gold Nanoparticles Using PEGylated Polyamidoamine Dendron in Aqueous Medium Reviewed

Atsushi Harada, Akihiko Yuzawa, Takeshi Kato, Chie Kojima, Kenji Kono

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY   48 ( 6 )   1391 - 1398   2010.3

pH-Sensitive fusogenic polymer-modified liposomes as a carrier of antigenic proteins for activation of cellular immunity. Reviewed

Yuba, E, Kojima, C, Harada, A, Tana, Watarai, S, Kono, K

Biomaterials   31   943 - 951   2010

Temperature-sensitive hyperbranched poly(glycidol)s with oligo(ethylene glycol) monoethers Reviewed

Kojima C, Yoshimura K, Harada A, Sakanishi Y, Kono K

Journal of Polymer Science, Part A: Polymer Chemistry   48 ( 18 )   4047 - 4054   2010

Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors Reviewed

Takahashi Toshinari, Yuba Eiji, Kojima Chie, Harada Atsushi, Kono Kenji

RESEARCH ON CHEMICAL INTERMEDIATES   35 ( 8-9 )   1005 - 1014   2009.11

Effect of Head Size in Head-Tail-Type Polycations on their in vitro Performances as Nonviral Gene Vectors Reviewed

Atsushi Harada, Masanori Kawamura, Yuka Kimura, Toshinari Takahashi, Chie Kojima, Kenji Kono

MACROMOLECULAR BIOSCIENCE   9 ( 6 )   605 - 612   2009.6

EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell-Cell Contacts Reviewed

Koichi Miura, Jin-Min Nam, Chie Kojima, Naoki Mochizuki, Hisataka Sabe

MOLECULAR BIOLOGY OF THE CELL   20 ( 7 )   1949 - 1959   2009.4

PREPARATION OF COMPLEXES OF LIPOSOMES WITH GOLD NANOPARTICLES Reviewed

Chie Kojima, Yusuke Hirano, Kenji Kono

METHODS IN ENZYMOLOGY; LIPOSOMES, PT F   464   131 - +   2009

Spontaneous formation of narrowly-distributed self-assembly from polyamidoamine dendron-poly(L-lysine) block copolymers through helix-coil transition of poly(L-lysine) block Reviewed

Harada A, Nakanishi K, Ichimura S, Kojima C, Kono K

Journal of Polymer Science, Part A: Polymer Chemistry   47 ( 4 )   1217 - 1223   2009

Preparation and characterization of complexes of liposomes with gold nanoparticles. Reviewed

Kojima C, Hirano Y, Yuba E, Harada A, Kono K

Colloids and surfaces. B, Biointerfaces   66 ( 2 )   246 - 252   2008.10

The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes Reviewed

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Kenji Kono

BIOMATERIALS   29 ( 29 )   4029 - 4036   2008.10

Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes. Reviewed

Yuba E, Kojima C, Sakaguchi N, Harada A, Koiwai K, Kono K

Journal of controlled release : official journal of the Controlled Release Society   130 ( 1 )   77 - 83   2008.8

Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes Reviewed

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Nobuhiko Emi, Kenji Kono

BIOCONJUGATE CHEMISTRY   19 ( 8 )   1588 - 1595   2008.8

Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: Their ability to sensitize stable liposomes to pH Reviewed

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kenji Kono

BIOCONJUGATE CHEMISTRY   19 ( 5 )   1040 - 1048   2008.5

Preparation of highly potent non-viral vectors by complexation of fusogenic polymermodified liposomes and lipoplexes Reviewed

Kono Kenji, Sakaguchi Naoki, Yuba Eiji, Kojima Chie, Harada Atsushi, Koiwai Kazunori

JOURNAL OF GENE MEDICINE   10 ( 4 )   469   2008.4

Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution Reviewed

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Kazuhiro Shimizu, Nobuhiko Emi, Kenji Kono

BIOMATERIALS   29 ( 9 )   1262 - 1272   2008.3

Preparation of gold nanoparticles grown in biocompatible dendrimer

Chie Kojima, Yasuhito Umeda, Atsushi Harada, Naoki Nakamura, Takashi Mukaiyama, Hiromichi Horinaka, Kenji Kono

8th World Biomaterials Congress 2008   4   2052   2008

Aqueous solubilization of fullerenes using poly(amidoamine) dendrimers bearing cyclodextrin and poly(ethylene glycol) Reviewed

Kojima C, Toi Y, Harada A, Kono K

Bioconjugate Chemistry   19 ( 11 )   2280 - 2284   2008

Polyion Complex Micelles Formed from Glucose Oxidase and Comb-Type Polyelectrolyte with Poly(Ethylene Glycol) Grafts Reviewed

Akifumi Kawamura, Chie Kojima, Michihiro Iijima, Atsushi Harada, Kenji Kono

Journal of Polymer Science Part A: Polymer Chemistry   46   3842 - 3852   2008

Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector Reviewed

Toshinari Takahashi, Chie Kojima, Atsushi Harada, Kenji Kono

BIOCONJUGATE CHEMISTRY   18 ( 4 )   1349 - 1354   2007.7

Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors Reviewed

Toshinari Takahashi, Jun Hirose, Chie Kojima, Atsushi Harada, Kenji Kono

BIOCONJUGATE CHEMISTRY   18 ( 4 )   1163 - 1169   2007.7

Temperature sensitivity control of alkylamide-terminated poly(amidoamine) dendrimers induced by guest molecule binding Reviewed

Kenji Kono, Takuma Miyoshi, Yasuhiro Haba, Etsuo Murakami, Chie Kojima, Atsushi Harada

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   129 ( 23 )   7222 - +   2007.6

Effect of polycarboxylate blocks on the amidase activity of trypsin through complexation with PEG/polycarboxylate block ionomers

Atsushi Harada, Yuriko Yoshioka, Akifumi Kawamura, Chie Kojima, Kenji Kono

MACROMOLECULAR BIOSCIENCE   7 ( 3 )   339 - 343   2007.3

Comparison of thermosensitive properties of poly(amidoamine) dendrimers with peripheral N-isopropylamide groups and linear polymers with the same groups Reviewed

Yasuhiro Haba, Chie Kojima, Atsushi Harada, Kenji Kono

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   46 ( 1-2 )   234 - 237   2007

Preparation of poly(ethylene glycol)-modified poly(amido amine) dendrimers encapsulating gold nanoparticles and their heat-generating ability Reviewed

Haba Y, Kojima C, Harada A, Ura T, Horinaka H, Kono K

Langmuir   23 ( 10 )   5243 - 5246   2007

Preparation of temperature-sensitive liposomes for delivery of anticancer drugs by use of thermosensitive amphiphilic block copolymer

Kenji Kono, Toshiaki Ozawa, Chie Kojima, Atsushi Harada, Shokyoku Kanaoka, Sadahito Aoshima, Kazuo Maruyama, Yukihito Ishizaka

AIChE Annual Meeting, Conference Proceedings   2006.12

Delivery of anticancer drugs mediated by thermosensitive polymer-modified liposomes

Kenji Kono, Toshiaki Ozawa, Jun Hirose, Chie Kojima, Atsushi Harada, Shokyoku Kanaoka, Sadahito Aoshima, Kazuo Maruyama, Yukihito Ishizaka

Polymer Preprints, Japan   55   5355 - 5356   2006.12

Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes Reviewed

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Kazuhiro Shimizu, Nobuhiko Emi, Kenji Kono

INTERNATIONAL JOURNAL OF PHARMACEUTICS   325 ( 1-2 )   186 - 190   2006.11

Suppression of tumor growth by thermosensitive polymer-modified liposomes containing anti-cancer drug

Kenji Kono, Toshiaki Ozawa, Jun Hirose, Chie Kojima, Atsushi Harada, Shokyoku Kanaoka, Sadahito Aoshima, Kazuo Maruyama, Yukihito Ishizaka

Polymer Preprints, Japan   55   1915   2006.10

Introduction of peptide ligands to thermosensitive polymer-modified liposomes using streptavidin-biotin interaction and their interaction with cells

Yutaka Nishimoto, Chie Kojima, Atsushi Harada, Yukihito Ishizaka, Shokyoku Kanaoka, Sadahito Aoshima, Kenji Kono

Polymer Preprints, Japan   55   2012   2006.10

Thermosensitive properties of poly(amidoamine) dendrimers with peripheral phenylalanine residues Reviewed

Tono Yohei, Kojima Chie, Haba Yasuhiro, Takahashi Toshinari, Harada Atsushi, Yagi Shigeyuki, Kono Kenji

LANGMUIR   22 ( 11 )   4920 - 4922   2006.5

Effect of head size in head-tail type polycation to their function as gene vector

Masanori Kawamura, Takashi Matsuo, Toshinari Takahashi, Chie Kojima, Atsushi Harada, Kenji Kono

Polymer Preprints, Japan   55 ( 1 )   2058   2006

Preparation of efficient gene carriers using polyamidoamine dendron-bearing cationic lipids with different alkyl chains

Toshinari Takahashi, Chie Kojima, Atsushi Harada, Kenji Kono

AIChE Annual Meeting, Conference Proceedings   2006

Effect of head size to the properties of head-tail type polycation vector

Atsushi Harada, Masanori Kawamura, Toshinari Takahashi, Chie Kojima, Kenji Kono

Polymer Preprints, Japan   55 ( 2 )   5363 - 5364   2006

Performance of PEG-attached dendrimers encapsulating photosensitizers for photodynamic therapy

Yoko Toi, Chie Kojima, Atsushi Harada, Kenji Kono

Polymer Preprints, Japan   55 ( 2 )   4909   2006

Influence of molecular structures of polyamidoamine dendron-bearing lipids on their function as gene vectors

Toshinari Takahashi, Chie Kojima, Atsushi Harada, Kenji Kono

Polymer Preprints, Japan   55 ( 1 )   1963   2006

Control of temperature-sensitive properties of poly(amidoamine) dendrimers using peripheral modification with various alkylamide groups Reviewed

Haba Y, Kojima C, Harada A, Kono K

Macromolecules   39 ( 21 )   7451 - 7453   2006

Transfection activity of lipoplexes containing cationic lipids with amidine group and influence of complexation with pH-sensitive polymer-modified liposomes Reviewed

Yuba E, Koiwai K, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   2014   2006

Synthesis of poly (amidoamine) dendrimers having phenylalanine residues in periphery and their transfection activity Reviewed

Tono Y, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   2062   2006

Synthesis of poly(amidoamine) dendron-bearing lipids having polyethylene glycol grafts and their use for preparation of gene vectors Reviewed

Hirose J, Takahashi T, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   2063   2006

pH-Responsive properties of liposomes modified with various poly(glycidol) derivatives with carboxyl groups Reviewed

Sakaguchi N, Koiwai K, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   2013   2006

Temperature-sensitive properties of poly(amidoamine) dendrimers having N-alkylamide groups in the periphery Reviewed

Haba Y, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   402   2006

Transfection activity of poly(amidoamine) dendrimers having peripheral phenylalanine residues Reviewed

Tono Y, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 2 )   4908   2006

Nanocapsulation of organic and inorganic compounds by poly(ethylene glycol)-attached dendrimers Reviewed

Kojima C, Toi Y, Haba Y, Harada A, Kono K

Polymer Preprints, Japan   55 ( 2 )   5109 - 5110   2006

Thermosensitive polymers with a 3 dimensional structure: Properties of thermosensitive dendrimers Reviewed

Kono K, Haba Y, Kojima C, Harada A

Polymer Preprints, Japan   55 ( 2 )   4951 - 4952   2006

Preparation of polyethylene glycol-modified poly(amidoamine) dendrimers encapsulating gold nanoparticles and their photothermal properties Reviewed

Haba Y, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   634   2006

Preparation of PEG-attached dendrimers encapsulating photosensitizers and their photocytotoxicity Reviewed

Toi Y, Kojima C, Harada A, Kono K

Polymer Preprints, Japan   55 ( 1 )   2049   2006

Regulation of epithelial cell-cell interaction by Arf6 signaling Reviewed

Koichi Miura, Hajime Yano, Yasuhito Onodera, Chie Kojima, Shigeru Hashimoto, Hisataka Sabe

CELL STRUCTURE AND FUNCTION   30   5 - 5   2005.6

EphA2受容体によるArf6の不活性化と上皮細胞間の接着制御(EphA2 engages Git1 to suppress Arf6 activity and modulate epithelial cell-cell contacts)

三浦 浩一, Nam Jin-Min, 児島 千恵, 望月 直樹, 佐邊 壽孝

日本生化学会大会プログラム・講演要旨集   82回   2T15p - 10   2009.9

A Collagen-Mimic Dendrimer Capable of Controlled Release

Chie Kojima, Sayako Tsumura, Atsushi Harada, Kenji Kono

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   131 ( 17 )   6052 - +   2009.5

セマフォリンシグナル伝達とエフリンシグナル伝達に関する最新の知見 上皮細胞間接触を制御するArf6のGit1による抑制におけるEphA2の関与(Recent advances in semaphorin signaling and ephrin signaling EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts)

三浦 浩一, Nam Jin-Min, 児島 千恵, 望月 直樹, 佐邊 壽孝

日本細胞生物学会大会講演要旨集   61回   112 - 112   2009.5

Synthesis and Characterization of Hyperbranched Poly(glycidol) Modified with pH- and Temperature-Sensitive Groups

Chie Kojima, Kohei Yoshimura, Atsushi Harada, Yuichi Sakanishi, Kenji Kono

BIOCONJUGATE CHEMISTRY   20 ( 5 )   1054 - 1057   2009.5

Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers with a shell of hydrophobic amino acid residues and their function as a nanocontainer

Kenji Kono, Takahiro Fukui, Toru Takagishi, Shinichi Sakurai, Chie Kojima

POLYMER   49 ( 12 )   2832 - 2838   2008.6

Preparation of poly(ethylene glycol)-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy

Chie Kojima, Yoko Toi, Atsushi Harada, Kenji Kono

BIOCONJUGATE CHEMISTRY   18 ( 3 )   663 - 670   2007.5

Regulation of Bin1 SH3 domain binding by phosphoinositides

C Kojima, A Hashimoto, Yabuta, I, M Hirose, S Hashimoto, Y Kanaho, H Sumimoto, T Ikegami, H Sabe

EMBO JOURNAL   23 ( 22 )   4413 - 4422   2004.11

A novel mode of action of an ArfGAP, AMAP2/PAG3/Pap alpha, in Arf6 function

S Hashimoto, A Hashimoto, A Yamada, C Kojima, H Yamamoto, T Tsutsumi, M Higashi, A Mizoguchi, R Yagi, H Sabe

JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 36 )   37677 - 37684   2004.9

Design of biocompatible dendrimers with environment sensitivity

C Kojima, Y Haba, T Fukui, K Kono, T Takagishi

MACROMOLECULES   36 ( 7 )   2183 - 2186   2003.4

PAG3/Pap alpha/KIAA0400, an ARFGAP, interacts with GTP-bound ARF6 and endocytic proteins

S Hashimoto, A Hashimoto, A Yamada, C Kojima, H Yamamoto, A Kondo, R Yagi, H Sabe

MOLECULAR BIOLOGY OF THE CELL   13   473A - 474A   2002.11

Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs

C Kojima, K Kono, K Maruyama, T Takagishi

BIOCONJUGATE CHEMISTRY   11 ( 6 )   910 - 917   2000.11

双性イオン分子を修飾したデンドリマーナノ粒子の水和状態と体内動態 [[C]C507-1pm-02]

児島 千恵, 平田 陸翔, 出井 菜々子, 何 浩, 松本 章一

日本化学会第105春季年会(2025)  2025.3 

デンドリマーナノ粒子を用いた腫瘍・免疫細胞へのDDS

児島千恵

熊本カンファレンス2024  2024.11 

Hydration states and biodistribution of various poly(ethylene glycol)-modified dendrimers International conference

Hao He, Junjie Yao, Akikazu Matsumoto, Chie Kojima

5th International Conference on Bioinspired and Zwitterionic Materials (ICBZM 2024)  2024 

カルボキシ末端Phe修飾ポリリシンデンドリグラフトの合成と免疫細胞へのＤＤＳ（1P-139）

酒井昭総, 松本章一, 児島千恵

日本バイオマテリアル学会  2024.10 

デンドリマー・金ナノ粒子とハイブリッドしたコラーゲンゲルを用いた細胞制御（3R05）

児島千恵

第 73 回高分子討論会  2024.9 

Application of zwitterionic polymer hydrogels to optical tissue clearing International conference

Chie Kojima

5th International Conference on Bioinspired and Zwitterionic Materials (ICBZM 2024)  2024.7 

フェニルアラニン修飾カルボキシ末端デンドリマーを用いた T 細胞への薬物・核酸デリバリー （23）

児島千恵

第 53 回医用高分子シンポジウム  2024.7 

構造が異なるポリエチレングリコール修飾デンドリマーの水和状態と体内動態（P20）

何 浩, 姚 俊捷, 松本章一, 児島千恵

第 53 回医用高分子シンポジウム  2024.7 

複数回投与時におけるPEGおよびスルホベタインポリマーを修飾したデンドリマーの腫瘍集積性（Jp2-B-4）

児島千恵, 姚 俊捷, 平田陸翔, 松本章一

第40回日本DDS学会学術集会  2024.7 

Applications of anionic-terminal Phe-modified dendrimers to delivery into lymph node-resident T cells International conference

Chie Kojima

12th World Biomaterials Congress (WBC2024)  2024.5 

複数回投与時のPEG修飾デンドリマー・リポソームの腫瘍集積性の相違複数回投与時のPEG修飾デンドリマー・リポソームの腫瘍集積性の相違（2H24）

児島千恵, 姚 俊捷, 松本章一

第73回高分子学会年次大会  2024.5 

スルホベタインモノマー・ポリマーを修飾したデンドリマーの合成と体内動態（3Pc065）

平田陸翔, 出井菜々子, 松本章一, 児島千恵

第73回高分子学会年次大会  2024.5 

フェニルアラニン修飾ポリエチレンイミンの刺激応答挙動（1Pf032）

池田朱里, 傅 云深, 松本章一, 児島千恵

第73回高分子学会年次大会  2024.5 

Modification of gold nanoparticles with alkanethiols inside thepolyethylene glycol-attached dendrimer

The 1st FAPS Polymer Congress  2009 

Modification of gold nanoparticles with alkanethiols inside thepolyethylene glycol-attached dendrimer

The 1st FAPS Polymer Congress  2009 

Preparation and cytotoxic activity of poly(ethyleneglycol)-modified poly(amidoamine) dendrimers bearing adriamycin

4th American Academy of Nanomedicine  2008 

Preparation and cytotoxic activity of poly(ethyleneglycol)-modified poly(amidoamine) dendrimers bearing adriamycin

4th American Academy of Nanomedicine  2008 

American Academy of Nanomedicine 4th Annual symposium, Young Investigator's Award

2008  

Development of Principle for Photothermal Fluidics and Nano-bio application

Grant number：26610089  2014.4 - 2016.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

Iida Takuya, TOKONAMI Shiho, KOJIMA Chie

Development of single-molecule thermometry based on thermoresponsive molecular tip of STM

Grant number：26620122  2014.4 - 2016.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

Nishino Tomoaki, KOJIMA Chie

Creation of Dynamical Biosensor and Photothermal Conversion Materials by Light-induced force

Grant number：23310079  2011.4 - 2014.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

IIDA Takuya, TOKONAMI Shiho, ITO Shoji, KOJIMA Chie

Development of novel CT contrast agents with long retention in the vessel

Grant number：21390343  2009 - 2011

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

SAKAHARA Harumi, MAGATA Yasuhiro, YAMAGUCHI Hiroshi, FUCHIGAMI Takeshi, OGAWA Mikako, KOJIMA Chie, SAKAI Toshihiro, TAKASHIMA Misato

Construction of drug delivery systems involving metastasis

Grant number：21700491  2009 - 2010

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

KOJIMA Chie, INUI Takashi

Development of multifunctional nano-vesicles having target accumulation, temperature-response, and imaging abilities

Grant number：19200040  2007 - 2010

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

KONO Kenji, AOSHIMA Sadahito, ISHIZAKA Yukihito, KOJIMA Chie

Construction of Novel Drug Delivery Systems Targeted to Metastatic Breast Cancers

Grant number：19700406  2007 - 2008

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

KOJIMA Chie

乳癌治療のための薬物運搬体ハイブリッドゲルの調製

Grant number：18800039  2006 - 2007

日本学術振興会  科学研究費助成事業  若手研究(スタートアップ)

児島 千恵

Preparation of efficient gene vectors with multi functions

Grant number：16300159  2004 - 2006

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

KONO Kenji, HARADA Atsush, EMI Nobuhiko, KADOWAKI Norimitsu, KOJIMA Chie

細胞骨格に関する研究

2002 - 2005

Research on the Cytoskeleton

2002 - 2005

ドラッグデリバリー

Small

Role(s)： Peer review

2024.9

J Biomaterials Science, Polymer Edition

Role(s)： Peer review

2024.9

Colloids and Surfaces B: Biointerfaces

Role(s)： Peer review

2024.9

J Biomaterials Science, Polymer Edition

Role(s)： Peer review

2024.8

European Polymer Journal

Role(s)： Peer review

2024.6

Polymer Journal

Role(s)： Peer review

2024.6

J Biomaterials Science, Polymer Edition

Role(s)： Peer review

2024.5

Journal of Molecular Liquids

Role(s)： Peer review

2024.4