Updated on 2026/02/04

写真a

 
AJIRI TAIGA
 
Organization
School of Life Science and Technology Assistant Professor
Title
Assistant Professor
External link

Degree

  • Ph.D. (Engineering) ( 2019.3   Hokkaido University )

Research Interests

  • ナノ構造体

  • 細胞外小胞

  • マイクロ流体デバイス

Education

  • Hokkaido University   Graduate School of Chemical Sciences and Engineering   Division of Chemical Sciences and Engineering

    2016.4 - 2019.3

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  • Hokkaido University   Graduate School of Chemical Sciences and Engineering   Division of Chemical Sciences and Engineering

    2014.4 - 2016.3

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  • Hokkaido University   School of Engineering   Department of Applied Science and Engineering

    2010.4 - 2014.3

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Research History

  • Institute of Science Tokyo   Department of Life Science and Technology   Assistant Professor

    2024.10

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  • Tokyo Institute of Technology   Department of Life Science and Technology   Assistant Professor

    2024.3 - 2024.9

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  • Sysmex corporation   Central Research Laboratory, Advanced Engineering Group

    2019.4 - 2024.2

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  • Hokkaido University   Graduate School of Chemical Sciences and Engineering   Research fellow of JSPS (DC2)

    2018.4 - 2019.3

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Papers

  • Routine monitoring of microRNAs in salivary exosomes using a cellulose nanofiber sheet

    Taiga Ajiri, Min Zhang, Naoya Mizukami, Mikiko Iida, Shota Kawaguchi, Yurie Sekihara, Kunanon Chattrairat, Zetao Zhu, Yoshinobu Baba, Hirotaka Koga, Takao Yasui

    Biosensors and Bioelectronics   299   118436 - 118436   2026.5

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bios.2026.118436

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  • An integrated high-throughput microfluidic circulatory fluorescence-activated cell sorting system (μ-CFACS) for the enrichment of rare cells

    Kunpeng Cai, Shruti Mankar, Taiga Ajiri, Kentaro Shirai, Tasuku Yotoriyama

    Lab on a Chip   21 ( 16 )   3112 - 3127   2021

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    Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    <p>A fully integrated high-throughput microfluidic circulatory fluorescence-activated cell sorting (μ-CFACS) system has been constructed for the contamination-free enrichment of rare cells in clinical environments.</p>

    DOI： 10.1039/d1lc00298h

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  • Silica Nanopillar Arrays for Monitoring Diffraction-Based Label-Free Biomolecule Separation

    Taiga Ajiri, Takao Yasui, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Junji Nishii, Yoshinobu Baba, Manabu Tokeshi

    ACS Applied Nano Materials   3 ( 9 )   8810 - 8816   2020.8

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsanm.0c01600

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  • Amplified piezoelectrically actuated on-chip flow switching for a rapid and stable microfluidic fluorescence activated cell sorter

    Kunpeng Cai, Shruti Mankar, Anastasia Maslova, Taiga Ajiri, Tasuku Yotoriyama

    RSC Advances   10 ( 66 )   40395 - 40405   2020

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    Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    <p>With the potential to avoid cross-contamination, eliminate bio-aerosols, and minimize device footprints, microfluidic fluorescence-activated cell sorting (μ-FACS) devices could become the platform for the next generation cell sorter.</p>

    DOI： 10.1039/d0ra04919k

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  • Using Laser Interference Lithography in the Fabrication of a Simplified Micro- and Nanofluidic Device for Label-free Detection

    Taiga Ajiri, Haruya Kasa, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Junji Nishii, Manabu Tokeshi

    Analytical Sciences   33 ( 10 )   1197 - 1199   2017.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.2116/analsci.33.1197

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    Other Link： https://link.springer.com/article/10.2116/analsci.33.1197/fulltext.html

  • Optimization of the nanofluidic design for label-free detection of biomolecules using a nanowall array

    Taiga Ajiri, Takao Yasui, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi

    Sensors and Actuators B: Chemical   250   39 - 43   2017.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.snb.2017.04.150

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  • Label-free detection of real-time DNA amplification using a nanofluidic diffraction grating

    Takao Yasui, Kensuke Ogawa, Noritada Kaji, Mats Nilsson, Taiga Ajiri, Manabu Tokeshi, Yasuhiro Horiike, Yoshinobu Baba

    Scientific Reports   6 ( 1 )   2016.8

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Quantitative DNA amplification using fluorescence labeling has played an important role in the recent, rapid progress of basic medical and molecular biological research. Here we report a label-free detection of real-time DNA amplification using a nanofluidic diffraction grating. Our detection system observed intensity changes during DNA amplification of diffracted light derived from the passage of a laser beam through nanochannels embedded in a microchannel. Numerical simulations revealed that the diffracted light intensity change in the nanofluidic diffraction grating was attributed to the change of refractive index. We showed the first case reported to date for label-free detection of real-time DNA amplification, such as specific DNA sequences from tubercle bacilli (TB) and human papillomavirus (HPV). Since our developed system allows quantification of the initial concentration of amplified DNA molecules ranging from 1 fM to 1 pM, we expect that it will offer a new strategy for developing fundamental techniques of medical applications.

    DOI： 10.1038/srep31642

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    Other Link： https://www.nature.com/articles/srep31642.pdf

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Books

  • AIとバイオの融合最前線

    阿尻大雅, 安井隆雄（ Role： Joint authorナノワイヤとAIによる尿中マイクロRNA解析と早期がん診断）

    CMC出版  2025.5  （ ISBN:9784781318677 ）

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    Responsible for pages：84-92   Language：Japanese  

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MISC

Presentations

  • QUASI-SINGLE-PARTICLE ANALYSIS OF EXTRACELLULAR VESICLES VIA MAGNETIC PARTICLES DECORATED WITH RADIAL ZINC OXIDE NANOWIRES

    Taiga Ajiri, Yurie Sekihara, Kunanon Chattraira, Zetao Zhu, Takao Yasui

    The 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (µTAS 2025)  2025.11 

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    Event date： 2025.11

    Language：English   Presentation type：Poster presentation  

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  • ナノワイヤ被覆磁性粒子を用いた細胞外小胞解析法の開発

    阿尻大雅, 関原由理江, Kunanon Chattraira, Zetao Zhu, 安井隆雄

    日本分析化学会第74年会  2025.9 

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    Event date： 2025.9

    Presentation type：Oral presentation (general)  

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  • TRACER-LABELED EXTRACELLULAR VESICLES FOR CONFIRMING EXTRACELLULAR VESICLES FILTRATION IN GLOMERULUS International conference

    Taiga Ajiri, Shota Kawaguchi, Rina Mitsuya, Atsushi Natsume, Ryosuke Kojima, Kiichi Sato, Takao Yasui

    The 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (µTAS 2024)  2024.10 

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    Event date： 2024.10

    Language：English   Presentation type：Poster presentation  

    Country：Canada  

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  • ナノ構造体を用いたDNAの分離・無標識検出 International conference

    阿尻大雅, 真栄城正寿, 石田晃彦, 谷博文, 西井準治, 渡慶次学, 安井隆雄

    第44回キャピラリー電気泳動シンポジウム（SCE2024）  2024.10 

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    Event date： 2024.10

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 追跡可能な細胞外小胞を用いた尿排出機構の解明

    阿尻大雅, 川口彰太, 三津屋里奈, 夏目敦至, 小嶋良輔, 佐藤記一, 安井隆雄

    日本分析化学会第73年会  2024.9 

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    Event date： 2024.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Au nanoparticle modified cellulose nanofiber sheet for direct observation of extracellular vesicles International conference

    Taiga Ajiri, Shota Kawaguchi, Kunanon Chattraira, Zetao Zhu, Takao Yasui

    RSC-JAIMA Symposium on Analytical Chemistry 2024  2024.9 

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    Event date： 2024.9

    Language：English   Presentation type：Poster presentation  

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  • Development of a Multifunctional Micro-Nano Device for Cancer Diaganosis

    Taiga Ajiri, Takao Yasui, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi

    The 7th Japan-China-Korea Joint conference on MEMS/NEMS 2016 (JCK MEMS/NEMS 2016)  2016.9 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Development of a damage-less and high-throughput rare cell sorting system Invited

    Taiga Ajiri

    2023.3 

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    Language：English   Presentation type：Oral presentation (invited, special)  

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Industrial property rights

  • 粒子分離チップおよび粒子分離装置

    阿尻 大雅, 白井 健太郎, 藤山 真吾, 小日向 寛之, 前田 夏希

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    Applicant：シスメックス株式会社

    Application no：特願2023-103519  Date applied：2023.6

    Announcement no：特開2025-003058  Date announced：2025.1

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  • 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ

    蔡 坤鵬, マンカー シュリティ, マスロバ アナスタシア, 阿尻 大雅, 阪井 裕美子, 渡部 俊介, 世取山 翼, 田川 礼人, 長谷川 武宏, 宮本 佳昭

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    Applicant：シスメックス株式会社

    Application no：特願2020-105774  Date applied：2020.6

    Announcement no：特開2022-000611  Date announced：2022.1

    Patent/Registration no：特許第7477378号  Date registered：2024.4 

    J-GLOBAL

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Awards

  • CHEMINAS Best Poster Award

    2018   ISMM 2018  

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  • Poster Award

    2018   CSJ Chemical festa  

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  • Poster Award

    2018   ITP2018  

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  • Student Travel Award for ITP2018

    2018   CASSS  

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  • Poster Award

    2015  

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Research Projects

  • Development of a Single-Cell Analysis Technology for Cancer Dynamics Based on Cellular Mechanical Properties

    2026.1 - 2027.12

    MSD Life Science Foundation, Public Interest Incorporated Foundation 

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    Authorship：Principal investigator 

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  • 細胞外小胞空間オミックス解析のための一粒子解析法の創出

    Grant number：24K23101  2024.7 - 2026.3

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    阿尻 大雅

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    Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）

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  • 等温遺伝子増幅法と多項目無標識検出法によるエクソソーム解析

    Grant number：18J11607  2018.4 - 2020.3

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    阿尻 大雅

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    Grant amount：\2100000 （ Direct Cost: \2100000 ）

    本研究では、等温遺伝子増幅法による目的物質由来シグナルの増幅と無標識検出を組み合わせ、超高感度でエクソソームをはじめとする複数のバイオマーカーを同時解析するマイクロチップの開発を目的とする。また、これまで開発してきた無標識検出システムとナノ構造体を用いた生体分子の高性能分離を組み合わせることによる、ハイスループットなエクソソーム内包microRNA解析方法の開発に取り組んでいる。
    本年度は、将来の実用化を見据え、解析用マイクロチップ作製方法の簡便化に取り組んだ。レーザー干渉露光法と一般的なフォトリソグラフィ技術を組み合わせることで、簡便にナノ構造体をマイクロ流路中に作製することが出来る。また、レーザー干渉露光法によって作成するナノ構造体のサイズは、厳密結合は理論に基づくシミュレーション解析により最適化を行い、作製したマイクロチップは、SEMとAFMによって評価した。周期構造のパターニングに限られるものの、レーザー干渉露光法を用いることで、簡便・迅速に流路をパターニングすることが可能となり、マイクロ・ナノ流体デバイス作製方法として有用であることを示した。
    試作したマイクロチップとこれまでに構築してきた無標識検出システムを用いて分離分析を行った。エクソソーム内包microRNAのモデル物質として、サイズの異なる二種類のDNAを用いて分離・無標識検出を行った。作製したナノピラーデバイスを用いることでDNA の分離場と検出場を分けることなく、無標識で分離の様子をモニタリングすることが出来た。また、YOYO-1 によって蛍光標識化した分離結果と比較を行った。無標識で分離分析を行うことで、より高性能な分離が達成される可能性が実験結果、計算結果双方から示唆された。本手法は、エクソソームに内包されたmicroRNAの複数同時解析への応用が期待される。

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