Language：English   Publishing type：Research paper (scientific journal)  

Sleep timing is an important output of the circadian system. The COVID-19-mandated social restrictions significantly altered commuting time and sleep duration regionally in Japan. This study aimed to elucidate sleep patterns, especially chronotype and social jetlag (SJL), due to changes in social time pressure through the social restrictions between the Metropolitan and Regional areas in Japan. As part of the Global Chrono Corona Survey 2020 (GCCS), the data were collected during social restrictions (SR), but pre-COVID-19 behaviours were also queried retrospectively. We analyzed a cohort of 729 respondents representing both the Metropolitan and the Regional areas separately for workdays and work-free days. While the areas showed no difference in SJL before SR, the differential decrease was larger in the Metropolitan area during SR, resulting in a significant difference in SJL between the areas. The outdoor light exposure before SR was 30 min longer in the Metropolitan areas than in the Regional; during SR both areas showed similarly low (below 1 h) outdoor light exposures. The variables associated with decreased SJL were the Metropolitan areas, work-from-home, a no-usage alarm clock on workdays, and chronotypes (mid-sleep time on free days corrected for sleep deficit accumulated over the workweek, MSFsc) during SR. The results suggest that relaxed social schedules, as reflected in the increased frequency of work-from-home and reduced alarm clock use, and moving towards earlier MSFsc during SR were linked to decreased SJL and were more prominent in the Metropolitan areas. This study provides insights into sleep patterns and the social time pressure markers, by comparison between residential groups in Japan.

DOI： 10.1080/07420528.2024.2340719

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BACKGROUND: Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. Sleep problems and habits among Japanese women across gestational stages have not been described. This study aimed to elucidate sleep problems, including a high risk of sleep-disordered breathing and sleep habits, among Japanese women across gestational progress, including postpartum. METHODS: A questionnaire survey using the Pittsburgh Sleep Quality Index (PSQI) and Berlin Questionnaire was conducted for 683 pregnant women (223 in the second trimester, 453 in the third trimester) and 386 postpartum (within 1 week after delivery). RESULTS: The total PSQI score was 5.3 [2.6] in the second trimester, 6.1 [2.8] in the third trimester, and 6.8 [3.1] in the first week postpartum. The percentage of those at high risk for sleep-disordered breathing, as determined by the Berlin Questionnaire, was 11.8% in the second trimester, 21.3% in the third trimester, and 19.2% in the first week postpartum, with the highest percentage of those at high risk in the third trimester of pregnancy. CONCLUSION: The PSQI total score exceeded the cut-off value in the third trimester and the first week postpartum, suggesting sleep deterioration. Therefore, it is necessary to understand and support sleep in pregnant women to ensure safe delivery, postpartum recovery, and health.

DOI： 10.1111/jog.15573

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Delayed sleep-wake phase disorder (DSWPD) is a sleep disorder in which the habitual sleep-wake timing is delayed, resulting in difficulty in falling asleep and waking up at the desired time. Patients with DSWPD frequently experience fatigue, impaired concentration, sleep deprivation during weekdays, and problems of absenteeism, which may be further complicated by depressive symptoms. DSWPD is typically prevalent during adolescence and young adulthood. Although there are no studies comparing internationally, the prevalence of DSWPD is estimated to be approximately 3% with little racial differences between Caucasians and Asians. The presence of this disorder is associated with various physiological, genetic and psychological as well as behavioral factors. Furthermore, social factors are also involved in the mechanism of DSWPD. Recently, delayed sleep phase and prolonged sleep duration in the young generation have been reported during the period of COVID-19 pandemic-related behavioral restrictions. This phenomenon raises a concern about the risk of a mismatch between their sleep-wake phase and social life that may lead to the development of DSWPD after the removal of these restrictions. Although the typical feature of DSWPD is a delay in circadian rhythms, individuals with DSWPD without having misalignment of objectively measured circadian rhythm markers account for approximately 40% of the cases, wherein the psychological and behavioral characteristics of young people, such as truancy and academic or social troubles, are largely involved in the mechanism of this disorder. Recent studies have shown that DSWPD is frequently comorbid with psychiatric disorders, particularly mood and neurodevelopmental disorders, both of which have a bidirectional association with the pathophysiology of DSWPD. Additionally, patients with DSWPD have a strong tendency toward neuroticism and anxiety, which may result in the aggravation of insomnia symptoms. Therefore, future studies should address the effectiveness of cognitive-behavioral approaches in addition to chronobiological approaches in the treatment of DSWPD.

DOI： 10.3389/fpsyt.2023.1174719

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Publishing type：Research paper (scientific journal)   Publisher：Informa UK Limited  

DOI： 10.1080/07420528.2022.2034839

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BACKGROUND: Delayed sleep-wake phase disorder (DSWPD) is more prevalent among the younger generation. However, the prevalence of this disorder in Asia, particularly Japan, has not yet been elucidated. Furthermore, the impact of DSWPD morbidity on daytime functioning and factors associated with the presence of the disorder remain unclear. METHODS: A web-based survey was conducted among youth aged 15-30 years. In total, 7,810 individuals completed the questionnaire. The questionnaire included items on sociodemographic variables as well as the Japanese version of the Biological Rhythms Interview of Assessment in Neuropsychiatry self-report (J-BRIAN-SR), which assesses the risk of DSWPD, sleep behaviors and possibly related lifestyle variables, productivity loss [WHO Health and Work Performance Questionnaire (HPQ)], and health-related quality of life (HRQOL). The risk of DSWPD was indicated by a J-BRIAN-SR score greater than or equal to 40 points and days of absence ≥4 days per month. After comparing these variables for participants at risk of DSWPD and those who were not, the factors associated with the risk of DSWPD were examined using logistic regression analysis, with sociodemographic and lifestyle variables as independent variables. RESULTS: The overall prevalence of participants at risk DSWPDs was 4.3%. Compared with participants without DSWPD, those at risk of DSWPD presented significantly worse HPQ and HRQOL scores. The risk of DSWPD was positively associated with the presence of currently treated diseases, length of nighttime liquid crystal display (LCD) viewing, and being a high school/university students. It was negatively associated with habitual exercise. CONCLUSION: The risk of DSWPD seemed to be consistent with reports from Western countries, and individuals possibly affected by the disorder were thought to have deteriorated daytime functioning. In addition, lifestyle specific to youth, such as long-term LCD viewing at night and relatively loose social constraints, could be associated with the presence of DSWPD in this generation.

DOI： 10.3389/fpsyt.2022.878042

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This web-based cross-sectional survey aimed to elucidate the differences between the two core symptoms of night eating syndrome (NES): evening hyperphagia and nocturnal ingestion in the general Japanese population aged 16-79 years. Participants who consumed at least 25% of daily calories after dinner were defined as having evening hyperphagia. Those who consumed food after sleep initiation at least twice a week were determined to have nocturnal ingestion. Of the 8348 participants, 119 (1.5%) were categorized in the evening hyperphagia group, 208 (2.6%) in the nocturnal ingestion group, and 8024 in the non-NES group. Participants with evening hyperphagia and nocturnal ingestion had significantly higher anxiety scores (p < 0.05 and p < 0.001, respectively) and depression (p < 0.001 for both) than those without NES. Multiple logistic regression analysis revealed that evening hyperphagia was significantly and independently associated with higher body mass index, shorter sleep duration, later sleep-wake schedule, and higher insomnia score, while nocturnal ingestion was significantly and independently associated with younger age, smoking habit, living alone, earlier sleep-wake schedule, and higher insomnia score. Sleep duration and sleep-wake schedule characteristics in the two groups were opposite, suggesting differences in the sleep pathophysiology mechanisms.

DOI： 10.3390/nu13114179

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Light is an important regulator of daily human physiology in providing time-of-day information for the circadian clock to stay synchronised with the 24-hr day. The coronavirus disease 2019 (COVID-19) pandemic led to social restrictions in many countries to prevent virus spreading, restrictions that dramatically altered daily routines and limited outdoor daylight exposure. We previously reported that sleep duration increased, social jetlag decreased, and mid-sleep times delayed during social restrictions (Global Chrono Corona Survey, N = 7,517). In the present study, we investigated in the same dataset changes in wellbeing and their link to outdoor daylight exposure, and sleep-wake behaviour. In social restrictions, median values of sleep quality, quality of life, physical activity and productivity deteriorated, while screen time increased, and outdoor daylight exposure was reduced by ~58%. Yet, many survey participants also reported no changes or even improvements. Larger reductions in outdoor daylight exposure were linked to deteriorations in wellbeing and delayed mid-sleep times. Notably, sleep duration was not associated with outdoor daylight exposure loss. Longer sleep and decreased alarm-clock use dose-dependently correlated with changes in sleep quality and quality of life. Regression analysis for each wellbeing aspect showed that a model with six predictors including both levels and their deltas of outdoor daylight exposure, sleep duration and mid-sleep timing explained 5%-10% of the variance in changes of wellbeing scores (except for productivity). As exposure to daylight may extenuate the negative effects of social restriction and prevent sleep disruption, public strategies during pandemics should actively foster spending more daytime outdoors.

DOI： 10.1111/jsr.13471

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AIM: The aim of this study was to investigate the impact of sleep problems on job stress in office workers. METHODS: This study included 4645 office workers from 29 companies who completed the study questionnaires between April 2017 and April 2019 in Japan. Sleep duration was assessed based on the participants' subjective sleep schedule on workdays and free days. The midpoint of sleep on free days (sleep-corrected) and social jetlag were calculated in accordance with the Munich Chronotype Questionnaire. To assess job stress, we used the 57-item Brief Job Stress Questionnaire. RESULTS: Multivariate logistic regression analysis revealed that the following factors were significantly associated with high job stress in office workers: a sleep duration <6 h on workdays (OR = 1.77, 95% CI = 1.46-2.15, P < 0.001), a sleep duration <6 h on free days (OR = 1.40, 95% CI = 1.05-1.87, P = 0.022), a sleep duration of at least 8 h on free days (OR = 1.31, 95% CI = 1.06-1.60, P = 0.011), and more than 2 h of social jetlag (OR = 1.33, 95% CI = 1.04-1.70, P = 0.022). CONCLUSION: This study suggests that insufficient sleep, long sleep durations on free days, and social jetlag may be associated with high job stress in office workers.

DOI： 10.1111/pcn.13274

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OBJECTIVE: The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) might be applicable for assessing delayed sleep-wake phase disorder (DSWPD). We aimed to investigate the reliability and validity of the Japanese version of the BRIAN self-report (J-BRIAN-SR) in DSWPD patients and determine a cutoff score to identify the presence of the disorder. METHODS: We enrolled 60 newly diagnosed DSWPD outpatients and 64 age-matched healthy controls. We used Cronbach's alpha for internal reliability to evaluate J-BRIAN-SR. We confirmed the reliability of the A test and re-test using Pearson's correlation coefficient in the controls. We used confirmatory factor analysis to evaluate the factor structure of J-BRIAN-SR and referenced the Morningness-Eveningness Questionnaire (MEQ) to check concurrent validity. We analyzed the receiver operating characteristic curve (ROC) to determine the J-BRIAN-SR cutoff point for the presence of DSWPD. RESULTS: The 18-component scores of the J-BRIAN-SR had an overall reliability coefficient (Cronbach's alpha) of 0.82. We confirmed a high test-retest reliability using an intraclass correlation coefficient (r = 0.84). The correlation between J-BRIAN-SR and MEQ was 0.38 (p = 0.003). The J-BRIAN-SR that we extracted by exploratory factor analysis consisted of three factors. A score of 40 points provided a sensitivity of 80.0% and a specificity of 75.6% for the positivity of DSWPD. CONCLUSIONS: The results of the present study revealed that J-BRIAN-SR is a valid and reliable instrument for screening and evaluating the severity of DSWPD. Our findings will be useful to physicians and patients in Japan and those in clinical settings.

DOI： 10.1016/j.sleep.2021.02.009

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The aim of the present study was to investigate the association among lunar cycle, menstrual cycle onset, and subjective sleep quality. Menstrual cycle onset data from the six most recent menstrual cycles were obtained for 529 women (aged 25-39 years) using the smartphone app Luna Luna. We also collected questionnaire survey data on sleep quality from each participant. Overall, there was no association between the onset of menstrual cycle and lunar phase. Interestingly, the proportion of good sleepers with menstrual cycle beginning during the light period was significantly higher than that during the dark period, while the proportion of poor sleepers with menstrual cycle beginning during the dark period was significantly higher than that during the light period. When participants were categorized by the combination of lunar phases (light, dark, neutral periods) in the two most recent menstrual cycle onsets, the "both dark period" group and the "other (light and dark) period" group showed the lowest proportion of good sleepers. Menstrual cycle onset in the dark period was associated with a deterioration in subsequent subjective sleep quality, which was more apparent with consecutive onsets in the dark period or at a rapidly changing lunar phase.

DOI： 10.3390/ijerph18063245

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Although sleep debt and social jetlag (SJL) influence daytime dysfunctions, the effects of both sleep debt and SJL on them have not been analyzed. The aim of this study was to examine the mutual relationship between sleep debt and SJL on daytime sleepiness, mood, and work performance. This study was a cross-sectional study on sleep health conducted on the Japanese general population. A total of 4505 general workers (30% female, aged 43.57 ± 11.63 years) were selected and analyzed. Sleep debt was defined by sleep debt index (SDI), which is the discrepancy between desired and real sleep duration. SJL and SDI scores exhibited a positive but weak coefficient (r = 0.19). In a 4 (SJL) × 3 (SDI) two-way ANOVA, the interaction effects were notable for sleepiness and depression scores, while the group effects were notable for the work performance score. For sleepiness and depression scores, SDI >2 h was not significantly different from SJL. In addition, the impact of SDI was higher than that of SJL on sleepiness (β = 0.17), depression (β = 0.16), and work performance (β = -0.10). The impact of sleep debt was more pronounced than SJL on daytime dysfunctions, although both sleep debt and SJL have negative impacts on them.

DOI： 10.3390/ijerph18062908

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Excessive daytime sleepiness is increasingly being recognized as a major global health concern. However, there have been few studies related to sleepiness and its associated factors in elementary school children. In Japan, all schools were closed from February to May 2020 to prevent coronavirus disease 2019 (COVID-19) outbreaks. The aim of this study was to identify changes in the subjective sleepiness of pupils during the 1.5-year period and to elucidate factors associated with changes in sleepiness. Questionnaire surveys about pupils' sleep habits and the Japanese version of the Pediatric Daytime Sleepiness Scale (PDSS-J) were conducted longitudinally at one elementary school in June 2019, January 2020, and June 2020. The average ∆PDSS score was 0.94 ± 5.51 (mean ± standard deviation) from June 2019 to January 2020 and -1.65 ± 5.71 (t[498] = 6.13, p < 0.01) from January 2020 to June 2020. Univariate and multivariate logistic regression analyses revealed that decreasing social jetlag was associated with decreasing PDSS scores (OR = 0.77, 95% CI: 0.62-0.96, p = 0.02) during the school closure. A less restrictive school schedule secondary to a COVID-19-related school closure decreased sleepiness in children and was associated with decreasing social jetlag.

DOI： 10.3390/children8030183

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Taylor and Francis Ltd.  

DOI： 10.1080/07420528.2021.1996388

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In humans, sleep regulation is tightly linked to social times that assign local time to events, such as school, work, or meals. The impact of these social times, collectively-social time pressure, on sleep has been studied epidemiologically via quantification of the discrepancy between sleep times on workdays and those on work-free days. This discrepancy is known as the social jetlag (SJL). COVID-19-mandated social restrictions (SR) constituted a global intervention by affecting social times worldwide. We launched a Global Chrono Corona Survey (GCCS) that queried sleep-wake times before and during SR (preSR and inSR). 11,431 adults from 40 countries responded between April 4 and May 6, 2020. The final sample consisted of 7517 respondents (68.2% females), who had been 32.7 ± 9.1 (mean ± sd) days under SR. SR led to robust changes: mid-sleep time on workdays and free days was delayed by 50 and 22 min, respectively; sleep duration increased on workdays by 26 min but shortened by 9 min on free days; SJL decreased by ~ 30 min. On workdays inSR, sleep-wake times in most people approached those of their preSR free days. Changes in sleep duration and SJL correlated with inSR-use of alarm clocks and were larger in young adults. The data indicate a massive sleep deficit under pre-pandemic social time pressure, provide insights to the actual sleep need of different age-groups and suggest that tolerable SJL is about 20 min. Relaxed social time pressure promotes more sleep, smaller SJL and reduced use of alarm clocks.

DOI： 10.1038/s41598-020-79299-7

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Several studies have assessed the effects of milk and dairy product intake on sleep quality and duration. Such investigations have varied in terms of their geographic locations, amounts of milk and dairy products, study participants (age, sex, race), and study designs. The present study aimed to summarize this literature and provide a unified view on whether the intake of milk and dairy products affects sleep quality. This systematic review was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The following keywords were chosen as electronic database search items from MeSH (medical subject headings) terms and descriptors in health sciences (DeHS) lists: milk, yogurt, dairy product, cheese, sleep, human, observational study, and interventional study. As a result, a total of 14 studies published between 1972 and 2019 were included in this review, including eight randomized controlled trials, two experimental studies with cross-over designs, one longitudinal study, and three cross-sectional studies. Four studies targeted older adults, three included toddlers, two targeted children, and six enrolled adults inclusive of university students. Overall, these studies indicated that a well-balanced diet that includes milk and dairy products is effective in improving sleep quality, despite mixed results across studies attributable to differences in study populations and methods.

DOI： 10.3390/ijerph17249440

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BACKGROUND: To date, no previous studies have evaluated the relationship between sleep duration and quality of life (QOL) or depression in the general population after controlling for daytime sleepiness and sleep disturbances. METHODS: A web-based cross-sectional survey was conducted with 8698 subjects aged 20-69 years. We examined the relationships between weekday sleep duration and daytime sleepiness, sleep disturbance, QOL and depression, using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (without the item for sleep duration), 8-item Short Form and Center for Epidemiological Studies Depression Scale (CES-D). RESULTS: Daytime sleepiness tended to increase in proportion to shorter weekday sleep durations. Sleep disturbances, physical and mental QOL, and CES-D scores were worse in both the shorter and longer sleep groups compared with the group with 7-8 h of sleep. Hierarchical logistic regression analyses revealed that short sleep duration but not long sleep duration was significantly associated with reduction of both physical and mental QOL, even after controlling for the presence of daytime sleepiness and sleep disturbance. Both short and long sleep duration were independently and significantly correlated with depression after controlling for daytime sleepiness; however, there was no statistically significant association after adjusting for the effects of sleep disturbance. CONCLUSIONS: The results suggested adverse effects of short sleep but not long sleep on both physical and mental QOL. In addition, the negative impact of specific types of sleep disturbance on depression may be greater than the impact of shortening of sleep duration.

DOI： 10.1016/j.sleep.2020.10.012

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DOI： 10.1016/j.sleep.2020.10.012

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DOI： 10.1007/s41105-019-00229-w

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Clock genes that comprise the circadian clock system control various physiological functions. Delayed sleep-wake phase disorder (DSWPD) and night eating syndrome (NES) are characterized by delayed sleep and meal timing, respectively. We estimated that clock gene expression rhythms in DSWPD patients may be delayed in comparison with the healthy subjects due to delayed melatonin secretion rhythms, producing eveningness chronotype in these individuals. However, it was difficult to estimate which clock gene expression rhythms were delayed or not in NES patients, because previous studies revealed that melatonin secretion rhythm was a little delayed compared with healthy individuals and that chronotype of NES patients depended on the individuals. Therefore, we examined expression rhythms of clock genes such as Period3 (Per3), nuclear receptor subfamily 1, group D, member 1 (Nr1d1) and Nr1d2 in these patients. Further, we expected sleep and meal patterns in DSWPD and NES patients may be more diverse than patterns observed in healthy subjects, and thus analyzed relationships among clock gene expression rhythms, sleep quality, sleep midpoint time, and meal times. We enrolled healthy male participants along with DSWPD and NES male patients, and asked all participants to answer questionnaires and to keep diaries to record information on their sleep and meals. Further, we asked them to collect 5-10 beard follicle samples, 6 times every 4 h. We measured clock gene expression rhythms using total RNA extracted from beard follicle cells. Peak time of clock gene expression in the NES group showed more diversity than the other groups, and that in the DSWPD group was delayed compared with the control group. In addition, the peak time of clock gene expression was negatively correlated with sleep quality and positively correlated with meal time after a long fast. Amplitudes of clock gene expression, especially Per3, positively responded to better mental and physical conditions as well as with better sleep quality. Results of this study suggest that peak times of clock gene expression in NES patients depended on the individuals; some patients with NES showed similar clock gene expression rhythm to healthy subjects, and other patients with NES showed similar to DSWPD patients. Moreover, this study suggests that meal time after a long fast may influence more determination in clock gene expression rhythms than the time of breakfast. Therefore, this study also indicates that Per3 clock gene may be one of the parameters that will help us understand sleep and meal rhythm disturbances.

DOI： 10.1080/07420528.2019.1585366

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Psychological Association  

DOI： 10.4992/jjpsy.90.18045

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Menstrual symptoms may have a significant impact on women's lives. Many women experience menses-related health problems, such as menstrual pain, heavy menstrual bleeding, and premenstrual syndrome, during their reproductively fertile years. Circadian misalignment in shift workers has been reported to contribute to menstrual cycle irregularity and/or painful menstruation. However, the relationship between social jetlag (SJL) and menstrual symptoms/menstrual cycle has not been elucidated. In this study, we aimed to elucidate this relationship among female university students. One-hundred and fifty female university students (mean [SD]: 18.8 [0.71]-years old) completed self-reported questionnaires consisting of menstrual symptoms and menstrual cycle, sleep quality and sleep habits, quality of life, and demographic variables. The average menstrual cycle was 32.0 [5.4] days. The percentage of students who showed menstrual cycle irregularity, having less than 25 days or more than 39 days of menstrual cycle during the previous four menstrual cycles, was 60.6%. SJL, the difference between mid-sleep time on free days and mid-sleep time on school days, was categorized into small (absolute SJL < 1 h) or large (≥1 h). Overall, 78.0% of participants had SJL ≥ 1 h. Among the menstrual symptoms, pain, behavioral change, and water retention subscale scores were significantly higher in the SJL ≥ 1 h group than in the SJL < 1 h group. However, no significant differences were found in concentration, autonomic reaction, or negative affect subscale scores between the two groups. The menstrual cycle was 31.2 [5.5] days in the SJL < 1 h group and 32.2 [5.4] days in the SJL ≥ 1 h group, without significant difference. Logistic regression analysis showed that more than 1 h of SJL was a significant associated factor with severe menstrual symptom, independently of sleep duration and late chronotype. This study indicated that SJL was a significant factor associated with severe menstrual symptoms, suggesting the possibilities of association between circadian system and reproductive function among humans.

DOI： 10.1080/07420528.2018.1533561

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

DOI： 10.1016/j.sleep.2017.10.011

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DOI： 10.4088/JCP.17m11565

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DOI： 10.1016/j.jad.2017.05.041

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DOI： 10.2147/NDT.S134814

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DOI： 10.2147/NDT.S134814

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DOI： 10.1016/j.sleep.2016.12.023

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Language：Japanese   Publisher：(公社)日本産業衛生学会  

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DOI： 10.1016/j.sleep.2016.04.008

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DOI： 10.3390/nu9020134

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DOI： 10.2147/NDT.S118759

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DOI： 10.1016/j.sleep.2016.04.011

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DOI： 10.4088/JCP.15m10055

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DOI： 10.1371/journal.pone.0159578

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DOI： 10.1080/07420528.2016.1213739

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DOI： 10.2147/NDT.S107462

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DOI： 10.2147/NDT.S118759

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DOI： 10.5664/jcsm.6048

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PURPOSE: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED). PATIENTS AND METHODS: We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative medications), and ten patients with drug-induced SRED (occurrence of SRED episodes after starting nightly medication of sedative drugs, which completely resolved after dose reduction or discontinuation of the sedatives). RESULTS: All patients with drug-induced SRED took multiple types of sedatives, such as benzodiazepines or benzodiazepine receptor agonists. Clinical features of drug-induced SRED compared with primary SRED were as follows: higher mean age of onset (40 years old in drug-induced SRED vs 26 years old in primary SRED), significantly higher rate of patients who had total amnesia during most of their SRED episodes (75.0% vs 31.8%), significantly lower rate of comorbidity of night eating syndrome (0% vs 63.3%), and significantly lower rate of history of sleepwalking (10.0% vs 46.7%). Increased doses of benzodiazepine receptor agonists may be responsible for drug-induced SRED. CONCLUSION: The clinical features of drug-induced SRED were different from those of primary SRED, possibly reflecting differences in the underlying mechanisms between these two categories of SREDs.

DOI： 10.2147/NDT.S107462

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DOI： 10.1016/j.psychres.2015.11.003

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Language：Japanese   Publisher：(一社)日本糖尿病合併症学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing  

DOI： 10.1111/sbr.12121

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DOI： 10.3109/07420528.2015.1048869

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DOI： 10.1016/j.sleep.2014.11.018

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DOI： 10.1007/s12529-014-9421-7

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DOI： 10.2147/NDT.595581

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DOI： 10.2147/NDT.S95681

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DOI： 10.1007/s12529-013-9371-5

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DOI： 10.1371/journal.pone.0113753

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Language：Japanese   Publisher：(NPO)日本睡眠歯科学会  

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Language：English   Publishing type：Part of collection (book)   Publisher：Elsevier Inc.  

DOI： 10.1016/B978-0-12-420168-2.00029-6

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DOI： 10.1016/j.sleep.2014.05.017

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2013.11.785

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jns.2013.11.001

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Language：Japanese  

J-GLOBAL

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.5664/jcsm.2666

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3109/07420528.2012.762010

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：American College of Chest Physicians  

DOI： 10.1378/chest.12-2609

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2012.06.015

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2012.05.015

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J-GLOBAL

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DOI： 10.1111/j.1479-8425.2012.00560.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jns.2012.03.013

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DOI： 10.1016/j.sleep.2011.07.020

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.4088/JCP.10m06286

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DOI： 10.1016/j.sleep.2011.10.016

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DOI： 10.1016/j.sleep.2011.07.014

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DOI： 10.1016/j.sleep.2011.10.017

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1479-8425.2011.00509.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.clinph.2011.05.024

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2169/internalmedicine.51.7518

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2169/internalmedicine.51.6101

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2011.06.014

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.ijpsycho.2011.09.012

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Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2010.12.017

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Language：Japanese   Publisher：日本生理心理学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1479-8425.2011.00498.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1620/tjem.224.127

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DOI： 10.1111/j.1479-8425.2010.00481.x

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DOI： 10.1111/j.1440-1819.2010.02154.x

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Language：Japanese   Publisher：Japanese Society of Public Health  

Objective The aim of this study is to reveal factors associated with both dozing off at the wheel and motor vehicle accidents (MVAs) with sleep apnea syndrome (SAS) as well as other descriptive variables for driving set as independent factors.<br/>Methods We conducted an anonymous questionnaire survey on drivers who visited the Tokyo Metropolitan Driver and Vehicle Licensing Center in order to renew their driver's license from September 25 to 29, 2006. The survey requested information regarding self reported experience of dozing off at the wheel, MVAs, usual mileage, length of license holding period, and the participants' awareness of SAS. We obtained data from 3,236 drivers (response rate: 61.8%).<br/>Results The rates for previous experience of feeling sleepiness at the wheel, that of dozing off at the wheel, and that of near-miss or actual MVA due to dozing off at the wheel among the participants were 40.4%, 20.3%, and 10.4% respectively. Multivariate logistic regression analysis revealed that dozing off at the wheel was significantly associated with male gender, long-term holding of a driver's license (≥3,<10 years: OR=1.58, 95%CI: 1.04–2.42, ≥10,<20 years: OR=2.23, 95%CI: 1.47–3.38, ≥20,<30 years: OR=1.89, 95%CI: 1.23–2.90, ≥30 years: OR=1.85, 95%CI: 1.18–2.89), higher usual mileage (≥30 km per a week: OR=1.35, 95%CI: 1.06–1.73), appearance of sleepiness shortly after starting driving (<2hrs: OR=1.99, 95%CI: 1.60–2.47), either having awareness or a diagnosis of SAS. As to experience of near-miss or actual MVA due to dozing off at the wheel, factors including male gender, long-term holding period of driver's license (≥3,<10 years: OR=2.02, 95%CI: 1.15–3.55, ≥10,<20 years: OR=2.10, 95%CI: 1.19–3.70), appearance of sleepiness shortly after starting driving (<2hrs: OR=1.70, 95%CI: 1.30–2.24), either having awareness or diagnosis of SAS were significantly associated.<br/>Conclusion Not only habituation effects and fatigue due to long driving but also SAS have a significant impact on the occurrence of sleepiness related MVAs. Moreover, early diagnosis and treatment of SAS is necessary so that we can avoid dozing off at the wheel, resulting in near-miss or actual MVA.

DOI： 10.11236/jph.57.12_1066

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Language：Japanese   Publisher：日本公衆衛生学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J01074&link_issn=&doc_id=20110106450003&doc_link_id=10027680118&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F10027680118&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Language：Japanese   Publisher：(株)ライフ・サイエンス  

J-GLOBAL

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/JOM.0b013e3181ea5a67

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1620/tjem.221.245

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DOI： 10.1111/j.1365-2869.2009.00806.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2009.09.011

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1183/09031936.00121608

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DOI： 10.1620/tjem.219.85

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Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2008.12.007

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1620/tjem.219.11

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Language：Japanese   Publisher：(株)ライフ・サイエンス  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1479-8425.2009.00394.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1378/chest.08-1414

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.sleep.2007.08.018

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Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：一般社団法人 日本女性心身医学会  

DOI： 10.18977/jspog.13.1-2_51_2

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DOI： 10.1111/j.1479-8425.2008.00335.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2114/jpa2.27.145

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Language：Japanese   Publisher：Japanese Society of Psychosomatic Medicine  

Several epidemiological studies have shown that sleep problems are common in Japanese general population. When treating sleep disorders, it is important to aim both at improving the disorder as well as often related dysfunctional daily life patterns. Recent studies have been designed specifically to evaluate the impact of sleep disorders on QOL (quality of life). The objective of this paper is to review the influence on social life of insomnia and insufficient sleep, which are the most common sleep disorders. Insomnia is statistically linked to a worsening of health condition. Persistent insomnia increases the risk of several somatic diseases such as hypertension and diabetes mellitus. In addition, the disorder has also a negative impact on waking functions related to quality of life, e.g. impaired concentration, impaired memory, decreased ability to accomplish daily tasks, and decreased enjoyment of interpersonal relationships. The risk of both work-related accidents and motor-vehicle accidents are usually found to be higher in insomniacs than in controls. Moreover, several studies have provided data suggesting that insomnia is one of the risk factors for the development of depression. Although chronic insufficient sleep and sleep loss are highly frequent in Japanese population, the number of insufficient sleepers who consult medical facilities is thought to be relatively low. From our study, 22% of the patients with insufficient sleep syndrome reported having had accidents or near misses. Moreover, the group of patients reporting these mishaps showed higher sleepiness scores than the other patients. This finding leads us to emphasize that insufficient sleep should not be overlooked and should be treated by prolonging nocturnal sleep and/or taking an appropriate daytime nap. Substantial treatment for sleep disorders usually improves not only sleep itself but also QOL. The importance of early recognition and treatment of sleep disorders as well as campaigns for sleep health awareness must be emphasized.

DOI： 10.15064/jjpm.47.9_785

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2007293349

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2466/PMS.103.2.307-317

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neulet.2005.03.058

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1440-1819.2005.01357.x

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Language：Japanese   Publisher：Japanese Soiety of Psychosomatic Obstetrics and Gynecology  

It is well known that intestinal motility has circadian rhythms as well as sleep-wake cycles and muramyl peptides affect sleep as the sleep-inducing substance. It is possible that bowel habits influence sleep health. The aim of this study is to epidemiologically investigate the relationship between bowel habits including functional constipation (FC) and irritable bowel syndrome (IBS), and sleep health. Young adult women living in the Tokyo metropolitan area were examined using the selfreported questionnaire. Subjects with FC or IBS were selected by Rome II. The score estimating the degree of parasomnia-like problems in FC and IBS was higher than in control. Weekday sleepiness in FC and IBS was also higher than in control. Weekday sleeping time in IBS was significantly shortened. The number of having breakfast, time cue of biological rhythms, was extremely decreased in FC. Irregularity of sleep onset time, sleeping time and sleep habits, which are related to biological rhythms, in FC and IBS were higher than in control. This study suggests that sleep health in FC and IBS is impaired compared with control and bowel habits may be related to sleep health. Bowel habits seem to be worthy of notice as a risk factor for sleep disorders.

DOI： 10.18977/jspog.10.2_67

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：Japan Society of Physiological Anthropology  

Since intestinal motility has circadian rhythms as well as sleep-wake cycles, it is possible that there are some relationships between functions of the gastrointestinal tract, especially intestinal motility, and sleep health. However, little is known about the relationships between intestinal motility and sleep health. Therefore, the relationships among functional constipation (FC), irritable bowel syndrome (IBS) and sleep health in the population of middle aged women living in the Tokyo metropolitan area were investigated using the self-reported questionnaire. FC and IBS were defined by the Rome diagnostic criteria for the functional gastrointestinal disorders (Rome II). As a result, both the sleep health in FC and in IBS were significantly worse than in control, and there was a tendency for the sleep health in IBS to be worse compared with that in FC. Accordingly, these results suggest that there are relationships between conditions of intestinal motility, namely bowel habits, and sleep health. In order to improve sleep disturbance coming into question in recent years, the consideration of bowel habits also seems to be important.

DOI： 10.20718/jjpa.9.1_15

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Language：Japanese   Publisher：Japan Society of Physiological Anthropology  

The present study was conducted to investigate the interactions in a pair for sleep health and sleep habits. A questionnaire was administered to daytime workers and their partners in a Tokyo metropolitan area, and healthy 249 pairs (20-59 years) were accepted for the analysis to find out risks in sleep health. Both wives and husbands whose partners showed higher risk scores in sleep health were in poor sleep health status. It was showed that sleep habits of husband affected sleep health of wife, but no effects of wife. The influences of husband's sleep were suggested to be predominant.

DOI： 10.20718/jjpa.8.1_17

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Language：Japanese   Publisher：Japanese Soiety of Psychosomatic Obstetrics and Gynecology  

The sleep disorder associated with pregnancy usually is biphasic, which typically begins with excessive sleepiness and develop to severe insomnia. The purpose of this study is to investigate into actual circumstances about sleep health, habits and symptoms of sleep disorders in pregnancy. Normal pregnant women (n=364, 29.7±4.2 years old) and healthy non-pregnant women (n=194,34.0±4.2 years old) living in the same area were asked the sleep-health used self-reported questionnaire with informed consent. There was no difference for sleep onset time between pregnant and non-pregnant women. Delayed rising time and prolonged sleep length in all trimesters of pregnancy were shown. The sleep maintenance and sleep initiating were disturbed in pregnant women. The prevalence of possible restless legs syndrome/possible periodic limb movement disorder was highest in 2 nd trimester (9.0%), however lower than it in the report of USA. Sleep bruxism was shown the highest prevalence in 1st trsis gravidarum disturbed sleep maintenance, sleep initiating and caused the deteriorated waking-up. This study showed that sleep was disturbed in 1 st trimester of pregnancy with high psychological anxiety, hyperemesis gravidarum. It was also suggested that the symptoms caused difficulty of sleep initiating, i. e. possible restless legs syndrome/possible periodic limb movement disorder, were appeared during all trimesters of pregnancy.imester. The prevalence of nocturnal leg cramps increased in pregnant women significantly. Hypereme

DOI： 10.18977/jspog.7.1_87

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Language：Japanese   Publisher：一般社団法人 日本女性心身医学会  

DOI： 10.18977/jspog.7.1_34_1

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Language：Japanese   Publisher：一般社団法人 日本女性心身医学会  

DOI： 10.18977/jspog.7.1_42_1

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/00994480.2001.10748333

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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Total pages：244  

ASIN

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Total pages：205  

ASIN

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Language：Japanese  

CiNii Books

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Language：Japanese   Publisher：日本医事新報社  

CiNii Books

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese  

J-GLOBAL

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Language：Japanese   Publisher：メディカルレビュー社  

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

CiNii Books

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2017405903

Language：Japanese   Publisher：メディカ出版  

CiNii Books

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：東京医科大学医学会  

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Language：Japanese   Publisher：(一社)日本糖尿病合併症学会  

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Language：Japanese   Publisher：日本公衆衛生学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：(一社)日本糖尿病学会  

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Language：Japanese   Publisher：(一社)日本糖尿病学会  

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

CiNii Books

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Language：Japanese   Publisher：日本公衆衛生学会  

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：English   Publishing type：Book review, literature introduction, etc.  

DOI： 10.1111/sbr.12064

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Language：Japanese  

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Language：Japanese  

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

CiNii Books

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Language：Japanese  

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Other Link： http://search.jamas.or.jp/link/ui/2014155081

Language：Japanese   Publisher：日本臨床精神神経薬理学会・日本神経精神薬理学会  

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Language：Japanese   Publisher：日本公衆衛生学会  

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Language：Japanese   Publisher：(株)三原医学社  

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Language：English   Publishing type：Book review, literature introduction, etc.  

DOI： 10.1016/j.iatssr.2013.06.001

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：日本医事新報社  

CiNii Books

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Language：Japanese  

J-GLOBAL

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Language：Japanese  

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Other Link： http://search.jamas.or.jp/link/ui/2014059504

Language：Japanese   Publisher：南江堂  

CiNii Books

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Language：Japanese  

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Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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Other Link： http://search.jamas.or.jp/link/ui/2013056910

Language：Japanese   Publisher：一般社団法人日本認知・行動療法学会  

CiNii Books

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：Japanese   Publisher：三原医学社  

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

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J-GLOBAL

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Language：Japanese   Publisher：先端医学社  

CiNii Books

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Language：Japanese   Publisher：(公財)明治安田厚生事業団  

東京都内の大学病院に勤務する看護師1111名に質問紙調査を行い、勤務形態の違いが睡眠・運動習慣・食生活に与える影響、健康関連QOLの低下や体重増加のリスク要因などについて検討した。結果、交替制勤務への従事や2交替・3交替という勤務形態の違いがQOLと体重増加に対して直接的に影響を与えていることを示唆するデータは得られなかった。しかし、QOLに対しては睡眠状態の悪化を通じて勤務形態が影響を与え、体重増加に対しては食生活の乱れを通じて勤務形態が影響を与えている可能性が示唆された。勤務形態別でQOLを比較すると3交替群よりも2交替群で低かった。

J-GLOBAL

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Language：Japanese   Publisher：南山堂  

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J-GLOBAL

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Language：Japanese   Publisher：ライフ・サイエンス  

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Language：Japanese   Publisher：エス・アールアカデミージャパン  

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Language：Japanese   Publisher：三井住友海上福祉財団  

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J-GLOBAL

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Language：Japanese   Publisher：一般社団法人日本認知・行動療法学会  

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Other Link： http://search.jamas.or.jp/link/ui/2011084849

Language：Japanese   Publisher：メディカルフロントインターナショナル(有)  

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Language：Japanese   Publisher：日本精神神経学会  

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CiNii Books

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Language：Japanese   Publisher：三原医学社  

CiNii Books

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Language：Japanese   Publisher：金原出版  

CiNii Books

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Language：Japanese   Publisher：メディカルフロントインターナショナル(有)  

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Language：Japanese   Publisher：ライフ・サイエンス  

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Language：Japanese   Publisher：日本不安症学会  

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：Japanese   Publisher：永井書店  

CiNii Books

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Language：Japanese   Publisher：(株)ライフ・サイエンス  

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Language：Japanese   Publisher：ライフ・サイエンス  

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Language：Japanese   Publisher：永井書店  

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Language：Japanese   Publisher：日本臨床社  

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Language：Japanese   Publisher：ライフ・サイエンス  

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J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：English   Publisher：Japan Society of Physiological Anthropology  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2008276816

Language：Japanese   Publisher：三原医学社  

CiNii Books

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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Language：Japanese   Publisher：じほう  

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Other Link： http://search.jamas.or.jp/link/ui/2008034233

Language：Japanese   Publisher：日本食品機械研究会  

CiNii Books

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：Japanese   Publisher：フレグランスジャーナル社  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2006255604

Language：Japanese   Publisher：じほう  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2005060366

Language：Japanese   Publisher：フレグランスジャーナル社  

CiNii Books

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Language：Japanese   Publisher：文光堂  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2004059686

Language：Japanese   Publisher：食品化学新聞社  

CiNii Books

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Language：English   Publisher：Japan Society of Physiological Anthropology  

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Other Link： http://search.jamas.or.jp/link/ui/2004281308

Language：Japanese  

CiNii Books

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Language：English   Publisher：Japan Society of Physiological Anthropology  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2002224933

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CiNii Books

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J-GLOBAL

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Language：Japanese   Publisher：The Illuminating Engineering Institute of Japan (IEIJ)  

The effects of simulating dawn lighting with an ordinary ceiling light on the quality of awakening were investigated. The subjects were healthy men, aged 24-27. After sleep for about 7 hours with polysomnographic recordings in a climatic chamber kept at a temperature of 25℃ and a relative humidity of 50%, each subject was awakened by an alarm. For the 30 minutes immediately before the subject was awakened, the illumination in the chamber was gradually increased, simulating the condition of waking up as the sun rises. Alpha attenuation test, measuring blood pressure and awakening feelings were conducted after awakening. The time of sleep stage 2 appearing during the 30 minute simulating dawn lighting was significantly less (p < 0.05; Wilcoxon test) than during typical waking conditions (i.e., waking up in the dark), while the time of stage W was higher (p = 0.0796). The mood after awakening in the simulating dawn lighting condition was significantly better (p < 0.05). There were no significant differences in the alpha attenuation coefficients and blood pressures after awakening between the two conditions. These results suggest that simulating dawn lighting arouses subjects to light sleep, which makes awakening less sudden and more pleasant. There was no evidence that the light sleep immediately before awakening decreased the subjects' cerebral cortex activity or sympathetic nervous activity after awakening.

CiNii Books

researchmap

Language：Japanese   Publisher：The Illuminating Engineering Institute of Japan (IEIJ)  

CiNii Books

researchmap

Language：Japanese  

CiNii Books

researchmap