Updated on 2025/12/05

写真a

 
Kanno Yusuke
 
Organization
Institute of Integrated Research Laboratory for Future Interdisciplinary Research of Science and Technology Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士(学術) ( 2017.3   Tohoku University )

Research Interests

  • 微粒子

  • 電気化学

  • バイオセンサ

  • マイクロ・ナノデバイス

Research Areas

  • Nanotechnology/Materials / Nano/micro-systems

Education

  • Tohoku University   Graduate School of Environmental Studies

    2014.4 - 2017.3

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  • Tohoku University   Graduate School of Environmental Studies

    2012.4 - 2014.3

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  • Tohoku University   Faculty of Engineering   Department of Applied Chemistry, Chemical Engineering and Biomolecular Engineering

    2008.4 - 2012.3

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Research History

  • Institute of Science Tokyo   Assistant Professor

    2024.10

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  • Tokyo Institute of Technology   Institute of Innovative Research   Assistant Professor

    2021.7 - 2024.9

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  • 株式会社リコー

    2017.4 - 2021.6

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  • 日本学術振興会 特別研究員 (DC2)

    2016.4 - 2017.3

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Professional Memberships

Committee Memberships

  •   Electrochemical Science Advances, Lead Guest Editor  

    2025   

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  •   日本動物実験代替法学会 3Rs啓発委員  

    2024 - 2025   

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    Committee type:Academic society

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  •   Frontiers in Bioengineering and Biotechnology, Guest Editor  

    2022 - 2024   

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  • 東京科学大学   生体医歯工学共同研究拠点成果報告会 実行委員  

    2025.3   

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  •   化学とマイクロ・ナノシステム学会 第47回研究会 実行委員  

    2023.5   

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  •   化学とマイクロ・ナノシステム学会 第46回研究会 若手企画実行委員  

    2022.11   

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Papers

  • Continuous production of monodisperse hydrogel particles through multiple laminar streams in deterministic lateral displacement micropillar arrays Reviewed

    Naotomo Tottori, Tang Yeyi, Yusuke Kanno, Takasi Nisisako

    Soft Matter   2025.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/D5SM00757G

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  • Tunable cell separation using a thermo-responsive deterministic lateral displacement device Reviewed

    Ze Jiang, Yusuke Kanno, Takasi Nisisako

    Lab on a Chip   25 ( 24 )   6454 - 6464   2025.9

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    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    Tunability in isolating target cells of varying sizes from complex heterogeneous samples is essential for biomedical research and diagnostics.

    DOI: 10.1039/d5lc00783f

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  • Precise Characterization of Individual Microfluidic Droplets Using Laser Diffraction Reviewed

    Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    ACS Measurement Science Au   5 ( 5 )   647 - 655   2025.8

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsmeasuresciau.5c00041

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  • Shear-Assisted Generation of Monodisperse Droplets with Tunable Sizes Using Slit-Based Step Emulsification Devices Reviewed

    Chunqi Zheng, Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    Industrial & Engineering Chemistry Research   64 ( 27 )   13720 - 13729   2025.6

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.iecr.5c00870

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  • Extended Spherical Diffusion Theory: Electrochemiluminescence Imaging Analysis of Diffusive Molecules from Spherical Biosamples Reviewed

    Kosuke Ino, Miyu Mashiko, Yusuke Kanno, Yeyi Tang, Shuzo Masui, Takasi Nisisako, Kaoru Hiramoto, Hiroya Abe, Hitoshi Shiku

    Analytical Chemistry   96 ( 48 )   18967 - 18976   2024.11

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.analchem.4c03167

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  • Upscaled Production of Satellite-Free Droplets: Step Emulsification with Deterministic Lateral Displacement Reviewed

    Guangchong Ji, Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    Micromachines   15 ( 7 )   908 - 908   2024.7

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    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Step emulsification is a key technique for achieving scalable production of monodisperse emulsion droplets owing to its resilience to flow fluctuations. However, the persistent issue of satellite droplets, an inherent byproduct of main droplets, poses challenges for achieving truly uniform product sizes. In a previous study, we introduced a module with step-emulsifier nozzles upstream and deterministic lateral displacement (DLD) micropillar arrays downstream to generate satellite-free droplets at a low throughput. In this study, we demonstrate an upscaled parallelized setup with ten modules that were designed to produce satellite-free droplets. Each module integrated 100 step-emulsification nozzles in the upstream region with DLD micropillar arrays downstream. We conducted 3D flow simulations to ensure homogeneous distribution of the input fluids. Uniformly supplying an aqueous polyvinyl alcohol solution and an acrylate monomer as continuous and dispersed phases into the ten modules, the nozzles in each module exhibited a production rate of 539.5 ± 28.6 drop/s (n = 10). We successfully isolated the main droplets with a mean diameter of 66 μm and a coefficient of variation of 3.1% from satellite droplets with a mean diameter of 3 μm. The total throughput was 3.0 mL/h. The high yield and contamination-free features of our approach are promising for diverse industrial applications.

    DOI: 10.3390/mi15070908

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  • Microfluidic Step Emulsification with Parallel Nozzles on a Vertical Slit Reviewed

    Chunqi Zheng, Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    Industrial & Engineering Chemistry Research   63 ( 23 )   10226 - 10233   2024.5

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.iecr.4c00542

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  • Understanding droplet breakup in a post-array device with sheath-flow configuration Reviewed

    Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    Lab on a Chip   2023.10

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    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    We found the power-law correlation for microfluidic droplet splitting can describe the mean droplet diameter generated in post-array devices.

    DOI: 10.1039/d3lc00573a

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  • Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles Reviewed

    Guangchong Ji, Yusuke Kanno, Takasi Nisisako

    Micromachines   2023.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/mi14030622

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  • Electrochemicolor imaging of endogenous alkaline phosphatase and respiratory activities of mesenchymal stem cell aggregates in early-stage osteodifferentiation Reviewed

    Kosuke Ino, Takehiro Onodera, Yusuke Kanno, Atsushi Suda, Ryota Kunikata, Tomokazu Matsue, Hitoshi Shiku

    Electrochimica Acta   268   554 - 561   2018.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.electacta.2018.02.094

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  • Micropatterning of Nafion Membranes on an Electrode Array Using Photolithographic and Lift-off Techniques for Selective Electrochemical Detection and Signal Accumulation Reviewed

    Mayuko Terauchi, Kosuke Ino, Yusuke Kanno, Shunsuke Imai, Hitoshi Shiku, Tomokazu Matsue

    Chemistry Letters   47 ( 2 )   204 - 206   2018.2

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    Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/cl.171031

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  • Electrochemicolor Imaging using an LSI-Based Device for Multiplexed Cell Assays Reviewed

    Yusuke Kanno, Kosuke Ino, Hiroya Abe, Chika Sakamoto, Takehiro Onodera, Kumi Y Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry   89 ( 23 )   12778 - 12786   2017.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.analchem.7b03042

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  • Binary-number-based digital electrochemical detection using a single working electrode with multiple sensors Reviewed

    Kosuke Ino, Yusuke Kanno, Yuta Yamada, Hitoshi Shiku, Tomokazu Matsue

    Electrochemistry Communications   77   76 - 80   2017.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.elecom.2017.02.016

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  • Electrochemical Motion Tracking of Microorganisms Using a Large-Scale-Integration-Based Amperometric Device Reviewed

    Kosuke Ino, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue

    Angewandte Chemie International Edition   56 ( 24 )   6818 - 6822   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201701541

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  • Molecular electrochemical switching element based on diffusive molecular competition for multipoint electrochemical detection of respiration activity of cell aggregates Reviewed

    Kosuke Ino, Yuta Yamada, Yusuke Kanno, Shunsuke Imai, Hitoshi Shiku, Tomokazu Matsue

    Sensors and Actuators B: Chemical   234   201 - 208   2016.10

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.snb.2016.04.160

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  • Potentiometric bioimaging with a large-scale integration (LSI)-based electrochemical device for detection of enzyme activity Reviewed

    Yusuke Kanno, Kosuke Ino, Chika Sakamoto, Kumi Y. Inoue, Masahki Matsudaira, Atsushi Suda, Ryota Kunikata, Tomohiro Ishikawa, Hiroya Abe, Hitoshi Shiku, Tomokazu Matsue

    Biosensors and Bioelectronics   77   709 - 714   2016.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.bios.2015.10.021

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  • Electrochemical Imaging for Single-cell Analysis of Cell Adhesion Using a Collagen-coated Large-scale Integration (LSI)-based Amperometric Device Reviewed

    Hiroya ABE, Yusuke KANNO, Kosuke INO, Kumi Y. INOUE, Atsushi SUDA, Ryota KUNIKATA, Masahki MATSUDAIRA, Hitoshi SHIKU, Tomokazu MATSUE

    Electrochemistry   84 ( 5 )   364 - 367   2016

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    Publishing type:Research paper (scientific journal)   Publisher:The Electrochemical Society of Japan  

    DOI: 10.5796/electrochemistry.84.364

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  • Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors Reviewed

    Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry   87 ( 12 )   6364 - 6370   2015.6

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acs.analchem.5b01307

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  • Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces using an LSI-based amperometric chip device with 400 sensors Reviewed

    Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Mustafa Şen, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hiroya Abe, Chen-Zhong Li, Hitoshi Shiku, Tomokazu Matsue

    Journal of Electroanalytical Chemistry   741   109 - 113   2015.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.jelechem.2015.01.020

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  • Simulation Analysis of Positional Relationship between Embryoid Bodies and Sensors on an LSI-based Amperometric Device for Electrochemical Imaging of Alkaline Phosphatase Activity Reviewed

    Yusuke KANNO, Kosuke INO, Kumi Y. INOUE, Atsushi SUDA, Ryota KUNIKATA, Masahki MATSUDAIRA, Hitoshi SHIKU, Tomokazu MATSUE

    Analytical Sciences   31 ( 7 )   715 - 719   2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Analytical Chemistry  

    In the present study, we monitored the alkaline phosphatase (ALP) activity of embryoid bodies (EBs) of mouse embryonic stem (ES) cells using a large-scale integration (LSI)-based amperometric device with 400 sensors and a pitch of 250 μm. In addition, a simulation analysis was performed to reveal the positional relationship between the EBs and the sensor electrodes toward more precise measurements. The study shows that simulation analysis can be applied for precise electrochemical imaging of three-dimensionally cultured cells by normalization of the current signals.

    DOI: 10.2116/analsci.31.715

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    Other Link: https://jlc.jst.go.jp/DN/JLC/20012936364?from=CiNii

  • Advanced LSI-based amperometric sensor array with light-shielding structure for effective removal of photocurrent and mode selectable function for individual operation of 400 electrodes Reviewed International journal

    Kumi Y. Inoue, Masahki Matsudaira, Masanori Nakano, Kosuke Ino, Chika Sakamoto, Yusuke Kanno, Reyushi Kubo, Ryota Kunikata, Atsushi Kira, Atsushi Suda, Ryota Tsurumi, Toshihito Shioya, Shinya Yoshida, Masanori Muroyama, Tomohiro Ishikawa, Hitoshi Shiku, Shiro Satoh, Masayoshi Esashi, Tomokazu Matsue

    Lab Chip   15 ( 3 )   848 - 856   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    We have developed a large-scale integrated (LSI) complementary metal-oxide semiconductor (CMOS)-based amperometric sensor array system called "Bio-LSI" as a platform for electrochemical bio-imaging and multi-point biosensing with 400 measurement points. In this study, we newly developed a Bio-LSI chip with a light-shield structure and a mode-selectable function with the aim of extending the application range of Bio-LSI. The light shield created by the top metal layer of the LSI chip significantly reduces the noise generated by the photocurrent, whose value is less than 1% of the previous Bio-LSI without the light shield. The mode-selectable function enables the individual operation of 400 electrodes in off, electrometer, V1, and V2 mode. The off-mode cuts the electrode from the electric circuit. The electrometer-mode reads out the electrode potential. The V1-mode and the V2-mode set the selected sensor electrode at two different independent voltages and read out the current. We demonstrated the usefulness of the mode-selectable function. First, we displayed a dot picture based on the redox reactions of 2.0 mM ferrocenemethanol at 400 electrodes by applying two different independent voltages using the V1 and V2 modes. Second, we carried out a simultaneous detection of O2 and H2O2 using the V1 and V2 modes. Third, we used the off and V1 modes for the modification of the osmium-polyvinylpyridine gel polymer containing horseradish peroxidase (Os-HRP) at the selected electrodes, which act as sensors for H2O2. These results confirm that the advanced version of Bio-LSI is a promising tool that can be applied to a wide range of analytical fields.

    DOI: 10.1039/c4lc01099j

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  • A local redox cycling-based electrochemical chip device with nanocavities for multi-electrochemical evaluation of embryoid bodies Reviewed

    Yusuke Kanno, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue

    Lab Chip   15 ( 23 )   4404 - 4414   2015

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/c5lc01016k

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  • Densified Electrochemical Sensors Based on Local Redox Cycling between Vertically Separated Electrodes in Substrate Generation/Chip Collection and Extended Feedback Modes Reviewed

    Kosuke Ino, Yusuke Kanno, Taku Nishijo, Hirokazu Komaki, Yuta Yamada, Shinya Yoshida, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry   86 ( 8 )   4016 - 4023   2014.4

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/ac500435d

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  • Droplet array on local redox cycling-based electrochemical (LRC-EC) chip device Reviewed

    Kosuke Ino, Takehito Goto, Yusuke Kanno, Kumi Y. Inoue, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Lab Chip   14 ( 4 )   787 - 794   2014

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    DOI: 10.1039/c3lc51156a

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  • SU-8-based Flexible Amperometric Device with IDA Electrodes to Regenerate Redox Species in Small Spaces Reviewed

    Yusuke KANNO, Takehito GOTO, Kosuke INO, Kumi Y. INOUE, Yasufumi TAKAHASHI, Hitoshi SHIKU, Tomokazu MATSUE

    Analytical Sciences   30 ( 2 )   305 - 309   2014

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2116/analsci.30.305

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  • Electrochemical Device with Interdigitated Ring Array Electrodes for Investigating the Relationship between Cardiomyocyte Differentiation from Embryonic Stem Cells and Alkaline Phosphatase Activity Reviewed

    Kosuke INO, Taku NISHIJO, Yusuke KANNO, Fumisato OZAWA, Toshiharu ARAI, Yasufumi TAKAHASHI, Hitoshi SHIKU, Tomokazu MATSUE

    Electrochemistry   81 ( 9 )   682 - 687   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5796/electrochemistry.81.682

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  • Novel Electrochemical Methodology for Activity Estimation of Alkaline Phosphatase Based on Solubility Difference Reviewed

    Kosuke Ino, Yusuke Kanno, Toshiharu Arai, Kumi Y. Inoue, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry   84 ( 18 )   7593 - 7598   2012.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ac301429n

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  • Local Redox-Cycling-Based Electrochemical Chip Device with Deep Microwells for Evaluation of Embryoid Bodies Reviewed

    Kosuke Ino, Taku Nishijo, Toshiharu Arai, Yusuke Kanno, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Angewandte Chemie International Edition   51 ( 27 )   6648 - 6652   2012.5

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1002/anie.201201602

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  • Electrochemical detection for dynamic analyses of a redox component in droplets using a local redox cycling-based electrochemical (LRC-EC) chip device Reviewed

    Kosuke Ino, Yusuke Kanno, Taku Nishijo, Takehito Goto, Toshiharu Arai, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Chemical Communications   48 ( 68 )   8505 - 8505   2012

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    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/c2cc34264b

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MISC

  • Scaling up microdroplet production with post-array devices Invited Reviewed

    Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    Biomicrofluidics   19 ( 3 )   031303   2025.5

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:AIP Publishing  

    Microfluidic systems capable of generating uniform droplets are gaining attention in food, cosmetics, biochemical, and materials applications. While conventional shear- or interfacial tension-driven nozzle devices can generate highly monodisperse droplets (CV < 5%), their scalability is limited by complex flow designs and clogging. Post-array devices have recently emerged as a high-throughput alternative, producing quasi-monodisperse droplets (CV > 12%) by sequentially breaking larger droplets using micro-post structures. These devices offer shear-dependent tunability of droplet sizes, greater resistance to clogging, and scalability. Notably, droplet size is strongly influenced by the dispersed phase fraction, enabling potential decoupling of droplet size and dispersed phase fraction. This study reviews the principles and performance of post-array devices, compares them with other droplet generation methods, and examines their similarities to droplet splitting in T-junctions and premix membrane emulsification. Challenges such as improving droplet uniformity and miniaturization are also discussed to highlight the potential of post-array systems for practical emulsification applications.

    DOI: 10.1063/5.0270507

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  • 先端的マイクロ流体技術による液滴と粒子の生成 Invited

    菅野佑介

    化学とマイクロ・ナノシステム学会誌   23 ( 2 )   57   2024.10

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    Publishing type:Article, review, commentary, editorial, etc. (other)  

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  • 熱応答性DLDデバイスを用いた細胞分離 Invited

    JIANG Ze, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会誌   23 ( 2 )   45 - 46   2024.10

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  • Editorial: Modelling and sensing platform for cancer and tumour microenvironment Reviewed

    Yuji Nashimoto, Yusuke Kanno, Hidenori Ito, Mustafa ŞEN

    Frontiers in Bioengineering and Biotechnology   12   2024.6

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Frontiers Media SA  

    DOI: 10.3389/fbioe.2024.1432352

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  • Electrochemical sensing strategies for on‐site testing of pathogenic nucleic acids Reviewed

    Yusuke Kanno, Shuzo Masui, Yusuke Ota, Ryoichi Saito, Takasi Nisisako

    Electrochemical Science Advances   2024.4

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Wiley  

    Abstract

    Rapid and reliable on‐site pathogen testing is crucial for diagnosing and managing human health. Nucleic acids (NAs) containing genetic information are valuable target molecules for pathogen testing, and sensitive and rapid detection of NAs using electrochemical approaches has been intensively investigated. Detection approaches for NAs are diverse and compatible with current gene amplification methods and continue to expand with the development of novel functional materials and molecules. The variety of electrochemical sensing devices also continues to expand, and more practical testing is being pursued. This review outlines the latest detection approaches and basic guidelines for NA detection. Furthermore, this review provides an overview of electrochemical sensing devices that utilize novel and unique materials and functions and comprehensively discusses their advantages.

    DOI: 10.1002/elsa.202400005

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  • Synthesis of functional polymeric microspheres via step emulsification and deterministic lateral displacement

    Guangchong JI, Yusuke Kanno, Takasi Nisisako

    Proceedings of MicroTAS2022   777 - 778   2022.10

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    Publishing type:Article, review, commentary, editorial, etc. (international conference proceedings)  

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  • Alkaline Phosphatase‐based Electrochemical Analysis for Point‐of‐Care Testing Reviewed

    Yusuke Kanno, Yuanshu Zhou, Takeshi Fukuma, Yasufumi Takahashi

    Electroanalysis   34 ( 2 )   161 - 167   2021.8

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Wiley  

    Abstract

    Point‐of‐care testing (POCT) devices have evolved to provide beneficial information about an individual's health whenever needed. Enzyme‐based analytical devices have facilitated the highly selective detection of numerous biological molecules and ions. Enzymes are commonly used as the tags of recognition components, such as antibodies, to generate and amplify detection signals. Particularly, alkaline phosphatase (ALP) is one of the most widely used enzymes because of its high turnover number and low cost. Rapid response time and the incorporation of many sensors fabricated by micro/nano processing technologies are the advantages in using electrochemical devices as analytical tools. Therefore, ALP‐based electrochemical devices have potential applications for more practical POCT platforms. This review summarizes recent research progress of ALP‐based electrochemical devices for POCT. In addition to ALP substrates, the application of ALP‐based immunosensors, aptasensors, and DNAzyme sensors are discussed.

    DOI: 10.1002/elan.202100294

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/elan.202100294

  • リチウムイオン電池の安全性向上に向けた機能性印刷の開発

    44   7 - 13   2020.8

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    Publishing type:Internal/External technical report, pre-print, etc.   Publisher:株式会社リコー  

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  • Multicolor Electrochemical Imaging for Simultaneous Multiplex Cell Assay Using a Chip Device Reviewed

    Yusuke Kanno, Kosuke Ino, Hiroya Abe, Kumi Y Inoue, Masahki Matsudaira, Atsushi Suda, Ryota Kunikata, Hitoshi Shiku, Tomokazu Matsue

    Proceedings of MicroTAS2016   104 - 105   2016.10

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (international conference proceedings)  

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  • Lsi-based amperometric device for electrochemical imaging of drug effect on dopamine release from three-dimensional cultured pc12 cells Reviewed

    H. Abe, K. Ino, C. Z. Li, Y. Kanno, K. Y. Inoue, A. Suda, R. Kunikata, M. Matsudaira, Y. Takahashi, H. Shiku, T. Matsue

    Proceedings of MicroTAS2015   1598 - 1600   2015

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  • Potentiometric Imaging of Stem Cells Using an LSI-based Electrochemical Chip Device with 400 Microelectrodes Reviewed

    Yusuke Kanno, Kosuke Ino, Chika Sakamoto, Kumi Y Inoue, Masahki Matsudaira, Atsushi Suda, Ryota Kunikata, Hiroya Abe, Hitoshi Shiku, Tomokazu Matsue

    Proceedings of MicroTAS2015   1686 - 1688   2015

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  • LSI-based amperometric chip device with 400 sensors for detection of alkaline phosphatase and respiration activities of embryonic stem cells Reviewed

    Yusuke Kanno, Kosuke Ino, Kumi Y Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue

    Proceedings of MicroTAS2014   2152 - 2154   2014

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  • Densified electrochemical sensor based on vertically separated electrode array for electrochemical imaging Reviewed

    K. Ino, Y. Kanno, H. Komaki, H. Shiku, T. Matsue

    Proceedings of MicroTAS2013   1282 - 1284   2013.10

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  • A High-Throughput Assay for Evaluation of Embryoid Bodies Using Local Redox Cycling-Based Electrochemical Chip Device Reviewed

    Kosuke Ino, Taku Nishijo, Yusuke Kanno, Hitoshi Shiku, Tomokazu Matsue

    ECS Transactions   50 ( 12 )   205 - 210   2013.3

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    Publisher:The Electrochemical Society  

    DOI: 10.1149/05012.0205ecst

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  • Comprehensive electrochemical imaging with local redox cycling-based electrochemical chip device for evaluation of three-dimensional culture cells Reviewed

    Kosuke Ino, Mustafa Sen, Taku Nishijo, Yusuke Kanno, Hitoshi Shiku, Tomokazu Matsue

    2012 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS)   16 - 18   2012

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    Web of Science

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  • Local redox cycling-based electrochemical chip devicefor high-throughput assay toward evaluating embryoid bodies Reviewed

    Kosuke Ino, Taku Nishijo, Yusuke Kanno, Hitoshi Shiku, Tomokazu Matsue

    Proceedings of MicroTAS2012   1345 - 1347   2012

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Presentations

  • MONODISPERSE PROTEIN GEL MICROSPHERES SYNTHESIZED VIA MICROFLUIDIC PRECURSORS WITH CONTROLLED SPATIAL DISPERSION

    Yusuke Kanno, Yeyi Tang, Takasi Nisisako

    MicroTAS2025  2025.11 

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  • Thermo-responsive micropillar arrays with engineered thermal gradients for tunable multi-stage particle separation

    Ze Jiang, Yusuke Kanno, Takasi Nisisako

    International Workshop on Nanodevice Technologies 2025 (IWNT2025)  2025.10 

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  • Continuous production of monodisperse cell-laden hydrogel particles through a micropillar array

    Yeyi Tang, Yusuke Kanno, Takasi Nisisako

    International Workshop on Nanodevice Technologies 2025 (IWNT2025)  2025.10 

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  • 単分散タンパク質ゲル微粒子の連続生成に向けたマイクロ流体デバイスの開発

    山竹龍宇, 菅野佑介, 唐叶毅, 西迫貴志

    化学とマイクロ・ナノシステム学会第51回研究会  2025.5 

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  • 超高密度電極デバイスを用いた局所レドックスサイクルによるバイオイメージング

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第27回研究会  2013.5 

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  • リング-リングナノギャップ電極による超高感度多点電気化学測定

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

    平成24年度化学系学協会東北大会  2012.9 

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  • 超高感度化に向けたナノ空間を有する多点電気化学デバイスの開発

    菅野佑介, 伊野浩介, 西條拓, 小沢文智, 珠玖仁, 末永智一

    電気化学会第80回大会  2013.3 

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  • LSI型電極アレイによる電気化学イメージングのカラー化

    菅野佑介, 伊野浩介, 阿部博弥, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    第76回分析化学討論会  2016.5 

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  • LSI-based microelectrode array chip device with 400 addressable sensors toward electrochemical imaging of stem cells

    Y. Kanno, K. Ino, C. Sakamoto, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Abe, H. Shiku, T. Matsue

    PACIFICHEM2015  2015.12 

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  • マルチカラー電気化学イメージングによる神経様細胞塊の多項目同時解析

    菅野佑介, 伊野浩介, 阿部博弥, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    電気化学会第83回大会  2016.3 

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  • Potentiometric imaging of stem cells using an LSI-based electrochemical chip device with 400 microelectrodes

    Y. Kanno, K. Ino, C. Sakamoto, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Abe, H. Shiku, T. Matsue

    MicroTAS2015  2015.10 

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  • 細胞の多項目同時解析に向けたマルチレンジ電気化学イメージングシステムの開発

    菅野佑介, 伊野浩介, 阿部博弥, 坂本ちか, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第32回研究会  2015.11 

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  • 三次元マイクロ・ナノ電極構造におけるレドックスサイクルを利用した多点電気化学デバイスの開発

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

    平成27年度日本分析化学会東北支部若手交流会  2015.7 

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  • Electrochemical imaging of stem cell function using high-sensitivity and high-resolution electrochemical chip devices

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

    第53回日本生物物理学会年会  2015.9 

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  • LSI電極アレイを用いた細胞活性のポテンショメトリックイメージング

    菅野佑介, 伊野浩介, 坂本ちか, 井上(安田)久美, 須田篤史, 國方亮太, 松平昌昭, 珠玖仁, 末永智一

    第75回分析化学討論会  2015.5 

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  • Potentiometric imaging for evaluation of cell activity using LSI-based electrochemical chip device with 400 sensors

    Y. Kanno, K. Ino, C. Sakamoto, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Abe, H. Shiku, T. Matsue

    ISMM2015  2015.6 

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  • Electrochemical imaging of cell activity based on measuring current and rest potential

    菅野佑介, 伊野浩介, 坂本ちか, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    日本化学会第97春季年会  2015.3 

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  • LSI-based amperometric chip device with 400 sensors for detection of alkaline phosphatase and respiration activities of embryonic stem cells

    Y. Kanno, K. Ino, K. Y. Inoue, A. Suda, R. Kunikata, M. Matsudaira, H. Shiku, T. Matsue

    MicroTAS2014  2014.10 

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  • LSI-based electrochemical chip device for multiple analysis of cell activities

    Y. Kanno, K. Ino, C. Sakamoto, K. Y. Inoue, A. Suda, R. Kunikata, M. Matsudaira, H. Shiku, T. Matsue

    EMNT2014  2014.12 

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  • バイオLSIを用いた幹細胞の機能評価

    菅野佑介, 伊野浩介, 小牧弘和, 井上(安田)久美, 須田篤史, 國方亮太, 松平昌昭, 珠玖仁, 末永智一

    2014年電気化学秋季大会  2014.9 

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  • バイオLSIを利用したアンペロメトリーおよびポテンショメトリーによる生体組織の多角的解析

    菅野佑介, 伊野浩介, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第30回研究会  2014.10 

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  • バイオLSIを利用した電気化学的バイオセンシング技術の開発

    菅野佑介, 伊野浩介, 井上(安田)久美, 國方亮太, 須田篤史, 松平昌昭, 珠玖仁, 末永智一

    第74回分析化学討論会  2014.5 

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  • 集積回路複合型電気化学デバイスを用いた材料表面の導電性とトポロジー評価法の開発

    菅野佑介, 伊野浩介, 井上(安田)久美, 山田祐大, 國方亮太, 須田篤史, 松平昌昭, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第29回研究会  2014.5 

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  • LSI-based electrochemical chip device for high-speed and high-sensitivity bioimaging

    Y. Kanno, K. Ino, K. Y. Inoue, M. Şen, R. Kunikata, A. Suda, H. Shiku, T. Matsue

    International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan  2013.9 

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  • バイオLSIを用いた高感度・高速電気化学測定に基づく細胞動態解析

    菅野佑介, 伊野浩介, 井上(安田)久美, 新井俊陽, 國方亮太, 須田篤史, 松平昌昭, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第28回研究会  2013.12 

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  • バイオLSIを用いた電気化学検出による超高感度・高速バイオイメージング

    菅野佑介, 伊野浩介, 小牧弘和, 井上(安田)久美, Mustafa Şen, 國方亮太, 須田篤史, 珠玖仁, 末永智一

    日本分析化学会第62年会  2013.9 

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  • LSI-based electrochemical platform containing 400 sensors for cell analysis

    Y. Kanno, K. Ino, K. Y. Inoue, R. Kunikata, A. Suda, H. Shiku, T. Matsue

    RSC Tokyo International Conference 2014  2013.9 

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  • 干渉リソグラフィーを用いた数μmサイズ液滴生成デバイスの作製

    増井周造, 道畑正岐, 高橋哲, 菅野佑介, 西迫貴志

    第72回応用物理学会春季学術講演会  2025.3 

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  • 平行スリットとマイクロ流路アレイによる単分散液滴生成

    豊福侑史, 西山昌孝, 菅野佑介, 西迫貴志

    第32回精密工学会学生会員卒業研究発表講演会  2025.3 

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  • Electrochemical Biosensing Based on Advanced Systems and Materials Invited

    2024.12 

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  • 円環スリット型マイクロ流路装置による単分散液滴の並列形成

    岡田祐太, 西山昌孝, 菅野佑介, 西迫貴志

    2025年度精密工学会春季大会学術講演会  2025.3 

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  • 円環型スリットデバイスを用いた単分散液滴の生成

    西山昌孝, ZHENG Chunqi, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第50回研究会  2024.11 

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  • 単一チップ上でのDewettingとDLDによる巨大リポソームの連続調製

    中山要, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第50回研究会  2024.11 

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  • Formation and separation of large droplets in a 3D-printed microfluidic device

    Y. Tang, G. Ji, Y. Kanno, T. Nisisako

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • マイクロ流路による薬剤内包PLGA粒子作製における乾燥法の影響

    呉田和優, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • Microfluidic step emulsification via paralleled generators on slits

    C. Zheng, G. Ji, S. Masui, Y. Kanno, T. Nisisako

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • ポストアレイ型液滴生成デバイスにおけるポストデザインの影響

    増井周造, 菅野佑介, 西迫貴志

    2023年度精密工学会春季大会学術講演会  2023.3 

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  • 凍結乾燥アルギン酸ゲル粒子の除藻剤放出速度の評価

    宮田佳奈, 菅野佑介, 西迫貴志

    第30回精密工学会学生会員卒業研究発表講演会  2023.3 

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  • A 3D-printed microfluidic device for integrated droplet generation and sorting

    2023.3 

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  • マイクロ流路を用いた薬剤内包PLGA粒子の作製と乾燥方法の検証

    呉田和優, 菅野佑介, 西迫貴志

    2023年度精密工学会春季大会学術講演会  2023.3 

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  • Inhibition of droplet clustering in step emulsification using deterministic lateral displacement

    G. Ji, Y. Kanno, T. Nisisako

    2023.3 

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  • Microfluidic step emulsification via parallel nozzles crossing a slit

    2023.3 

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  • Microfluidic synthesis of polymer particles using step emulsification and deterministic lateral displacement

    2022.11 

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  • シースフロー型ポストアレイデバイスによる液滴生成

    増井周造, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第46回研究会  2022.11 

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  • Synthesis of Functional Polymeric Microspheres via Step Emulsification and Deterministic Lateral Displacement

    G. Ji, Y. Kanno, T. Nisisako

    MicroTAS2022  2022.10 

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  • クロススリット型液滴生成デバイスの3次元流路構造の検討

    古山侑, 菅野佑介, 西迫貴志

    2022年度精密工学会春季大会学術講演会  2022.3 

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  • 局所親水化PDMS流路による単核薄膜ダブルエマルションの1ステップ生成

    前嶋完紀, 菅野佑介, 西迫貴志

    2022年度精密工学会春季大会学術講演会  2022.3 

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  • 微小電極群による電気化学バイオセンシング

    菅野佑介

    第12回IDEA連携シンポジウム  2022.3 

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  • Microfluidic step emulsification and deterministic lateral displacement

    2022.3 

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  • Multicolor electrochemical imaging for simultaneous multiplex cell assay using a chip device

    Y. Kanno, K. Ino, H. Abe, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Shiku, T. Matsue

    MicroTAS2016  2016.10 

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  • 多項目細胞解析に向けたElectrochemicolor イメージング法の開発

    菅野佑介, 伊野浩介, 阿部博弥, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    電気化学会東北支部第47回セミコンファレンス  2016.11 

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  • 大規模な電極アレイ計測を実現する電気化学シグナル分離システム

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会第34回研究会  2016.9 

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  • A novel amperometric imaging system for simultaneously monitoring different cell functions

    Y. Kanno, K. Ino, H. Abe, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Shiku, T. Matsue

    RSC Tokyo International Conference 2016  2016.9 

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  • Electrochemicolorイメージング法の構築と細胞解析への応用

    菅野佑介, 伊野浩介, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

    平成28年度東日本分析化学若手交流会  2016.7 

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  • ナノ空間電極アレイを用いた細胞スフェロイドの高感度スクリーニング

    菅野佑介

    日本生物工学会セルプロセッシング計測評価研究部 第8回若手研究シンポジウム  2016.7 

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  • MICROFLUIDIC JETTING IN A STEP EMULSIFICATION SLIT DEVICE

    Chunqi Zheng, Shuzo Masui, Yusuke Kanno, Takasi Nisisako

    MicroTAS2024  2024.10 

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  • 単分散酵素ゲル微粒子のマイクロ流体生成

    菅野佑介, 唐叶毅, 西迫貴志

    化学とマイクロ・ナノシステム学会第50回研究会  2024.11 

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  • THERMO-RESPONSIVE DETERMINISTIC LATERAL DISPLACEMENT FOR CELL SEPARATION

    Ze Jiang, Yusuke Kanno, Takasi Nisisako

    MicroTAS2024  2024.10 

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  • MICROFLUIDIC MANUFACTURING AND BIOSENSOR APPLICATION OF MAGNETIC FIELD-RESPONSIVE GLUCOSE OXIDASE BEADS

    Yusuke Kanno, Yeyi Tang, Shuzo Masui, Takasi Nisisako

    MicroTAS2024  2024.10 

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  • CELL SPHEROID SEPARATION IN A 3D-PRINTED MICROPILLAR ARRAY DEVICE

    Yeyi Tang, Yusuke Kanno, Takasi Nisisako

    MicroTAS2024  2024.10 

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  • Cell separation in a thermo-responsive deterministic lateral displacement device

    Ze Jiang, Yusuke Kanno, Takasi Nisisako

    化学とマイクロ・ナノシステム学会第49回研究会  2024.6 

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  • 液滴並列形成スリットデバイスにおける液滴の微小化

    西山昌孝, Chunqi ZHENG, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第49回研究会  2024.6 

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  • マイクロ流路内dewettingとDLDによる巨大リポソームの調製

    中山要, 増井周造, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第49回研究会  2024.6 

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  • A deterministic lateral displacement device for size-based separation of cell spheroids

    Yeyi Tang, Yusuke Kanno, Takasi Nisisako

    化学とマイクロ・ナノシステム学会第49回研究会  2024.6 

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  • Thermo-responsive micropillars on a silicon chip for tunable deterministic lateral displacement

    Ze Jiang, Yusuke Kanno, Takasi Nisisako

    2024年度精密工学会春季大会学術講演会  2024.3 

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  • 磁場応答性タンパク質ゲル微粒子を用いたグルコースセンシング

    菅野佑介, 唐叶毅, 増井周造, 西迫貴志

    電気化学会第91回大会  2024.3 

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  • スリット型液滴量産デバイスにおける液滴の微細化検討

    西山昌孝, Chunqi ZHENG, 菅野佑介, 西迫貴志

    2024年度精密工学会春季大会学術講演会  2024.3 

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  • レーザー回折散乱法によるマイクロ流路内での液滴計測

    増井周造, 菅野佑介, 西迫貴志

    2024年度精密工学会春季大会学術講演会  2024.3 

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  • マイクロミキサーを用いた転相乳化によるナノエマルション調製

    増井周造, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第48回研究会  2023.11 

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  • Protein Gel Microparticles with Magnetic Responsivity for Electrochemical Sensors Invited

    2023.11 

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  • バイオセンサ応用を指向した磁場応答性タンパク質ゲル微粒子の開発

    菅野佑介, 唐叶毅, 増井周造, 西迫貴志

    化学とマイクロ・ナノシステム学会第48回研究会  2023.11 

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  • Evaluating particle separation in a 3D-printed deterministic lateral displacement device

    Y. Tang, G. Ji, Y. Kanno, T. Nisisako

    10th International Conference of Asian Society for Precision Engineering and Nanotechnology(ASPEN2023)  2023.11 

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  • A microfluidic step-emulsification device with nozzles arrayed on a slit

    C. Zheng, S. Masui, Y. Kanno, T. Nisisako

    10th International Conference of Asian Society for Precision Engineering and Nanotechnology(ASPEN2023)  2023.11 

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  • ポストアレイデバイスによる多相エマルションのオンチップ生成

    増井周造, 菅野佑介, 西迫貴志

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • CHARACTERIZATION OF DROPLET GENERATION THROUGH A POST-ARRAY DEVICE

    S. Masui, Y. Kanno, T. Nisisako

    MicroTAS2023  2023.10 

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  • On -chip production of alginate hydrogel microparticles using step emulsification and deterministic lateral displacement

    G. Ji, Y. Kanno, T. Nisisako

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • 除藻剤内包アルギン酸ゲル粒子の薬剤放出速度に影響する因子の理解

    菅野佑介, 宮田佳奈, 西迫貴志

    化学とマイクロ・ナノシステム学会第47回研究会  2023.5 

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  • A fully PDMS slit-based device for parallel droplet generation

    Hantian Zhang, Yusuke Kanno, Takasi Nisisako

    International Workshop on Nanodevice Technologies 2025 (IWNT2025)  2025.10 

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Industrial property rights

  • 正極活物質、正極、電極素子、蓄電デバイス

    菅野佑介, 柳田英雄, 中島聡, 鈴木栄子, 広渡杏奈

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    Applicant:株式会社リコー

    Application no:特願2019-166136  Date applied:2019.9

    Announcement no:特開2020-149964  Date announced:2020.9

    Patent/Registration no:特許第6791328号  Date registered:2020.11 

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  • 複合材料の製造方法

    菅野佑介, 柳田英雄, 中島聡, 鈴木栄子, 広渡杏奈

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    Applicant:株式会社リコー

    Application no:特願2019-045259  Date applied:2019.3

    Announcement no:特開2020-149825  Date announced:2020.9

    Patent/Registration no:特許第7358752号  Date registered:2023.10 

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  • ELECTROCHEMICAL MEASUREMENT APPARATUS AND TRANSDUCER

    Kosuke INO, Yusuke KANNO, Tomokazu MATSUE, Kumi INOUE, Ryota KUNIKATA, Hiroyuki HAYASHI, Atsushi SUDA

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    Application no:17027172 

    Announcement no:特開20210003549 

    Patent/Registration no:US12105080  Date registered:2024.10 

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  • 液体組成物、多孔質膜、電極、蓄電素子、及びリチウムイオン二次電池

    野勢大輔, 菅野佑介, 東隆司, 松岡康司, 大村知也

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    Application no:特願202100999  Date applied:2021.7

    Announcement no:特開2023-015601 

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  • 電極用混合層、電極、及び電気化学素子

    座間優, 川瀬広光, 松岡康司, 柳田英雄, 升澤正弘, 東隆司, 森田充展, 今野剛彰, 平岡孝朗, 白石尚輝, 浮ヶ谷将之, 菅野佑介, 綾大, 武井悠記

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    Application no:特願2020-212828  Date applied:2020.12

    Announcement no:特開2021-136232  Date announced:2021.9

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  • COMPOSITE MATERIAL, ELECTRODE, ELECTRODE DEVICE, POWER STORAGE DEVICE AND METHOD OF MANUFACTURING COMPOSITE MATERIAL

    KANNO YUSUKE, YANAGITA HIDEO, NAKAJIMA SATOSHI, SUZUKI EIKO, HIROWATARI ANNA

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    Application no:EP20162378  Date applied:2020.3

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  • 液体組成物、電極の製造方法及び電気化学素子の製造方法

    川瀬広光, 座間優, 木村興利, 松岡康司, 東隆司, 菅野佑介, 柳田英雄, 升澤正弘

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    Application no:特願2020-29894  Date applied:2020.2

    Announcement no:特開2021-134251  Date announced:2021.9

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  • 液体組成物及び電気化学素子の製造方法

    松岡康司, 東隆司, 升澤正弘, 柳田英雄, 座間優, 大村知也, 菅野佑介, 野勢大輔

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    Application no:特願2019-210551  Date applied:2019.11

    Announcement no:特開2021-80404  Date announced:2021.5

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  • POWER STORAGE ELEMENT AND POWER STORAGE SYSTEM

    HIROMICHI KURIYAMA, MASAMI TAKAI, EIKO SUZUKI, NAKAJIMA SATOSHI, YANAGITA HIDEO, SHIGEO TAKEUCH, YUSUKE SUGANO

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    Application no:CN201910555217.1  Date applied:2019.6

    Patent/Registration no:CN110658456  Date registered:2022.5 

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  • 複合材料、電極、電極素子、蓄電デバイス

    菅野佑介, 柳田英雄, 中島聡, 鈴木栄子, 広渡杏奈

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    Applicant:株式会社リコー

    Application no:特願2019-045260  Date applied:2019.3

    Announcement no:特開2020-149826  Date announced:2020.9

    Patent/Registration no:特許第7275675号  Date registered:2023.5 

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  • 正極、非水系蓄電素子及び正極合材用塗布液

    柳田英雄, 鈴木栄子, 中島聡, 菅野佑介, 座間優, 広渡杏奈

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    Applicant:株式会社リコー

    Application no:特願2018-227390  Date applied:2018.12

    Announcement no:特開2019-164986  Date announced:2019.9

    Patent/Registration no:特許第7302165号  Date registered:2023.6 

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  • 電極及びその製造方法、電極素子、非水電解液蓄電素子

    座間優, 柳田英雄, 広渡杏奈, 吉田綾, 升澤正弘, 松岡康司, 鈴木栄子, 中島聡, 栗山博道, 菅野佑介

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    Applicant:株式会社リコー

    Application no:特願2018-211765  Date applied:2018.11

    Announcement no:特開2019-164982  Date announced:2019.9

    Patent/Registration no:特許第7225714号  Date registered:2023.2 

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  • 電極、電極素子、非水電解液蓄電素子

    川瀬広光, 座間優, 木村興利, 柳田英雄, 広渡杏奈, 菅野佑介, 升澤正弘, 吉田綾, 竹内重雄

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    Applicant:株式会社リコー

    Application no:特願2018-190391  Date applied:2018.10

    Announcement no:特開2020-061226  Date announced:2020.4

    Patent/Registration no:特許第7222212号  Date registered:2023.2 

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  • 蓄電素子及び蓄電システム

    栗山博道, 高井正巳, 鈴木栄子, 中島聡, 柳田英雄, 竹内重雄, 菅野佑介

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    Applicant:株式会社リコー

    Application no:特願2018-125171  Date applied:2018.6

    Announcement no:特開2020-005467  Date announced:2020.1

    Patent/Registration no:特許第7214993号  Date registered:2023.1 

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  • 電気化学イメージング方法、電気化学測定装置及びトランスデューサ

    伊野浩介, 菅野佑介, 末永智一, 井上久美, 國方亮太, 林泰之, 須田篤史

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    Applicant:国立大学法人東北大学, 日本航空電子工業株式会社

    Application no:特願2016-101043  Date applied:2016.5

    Announcement no:特開2017-207410  Date announced:2017.11

    Patent/Registration no:特許第6344775号  Date registered:2018.6  Date issued:2018.6

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  • LIQUID COMPOSITION, METHOD OF MANUFACTURING ELECTRODES AND METHOD OF MANUFACTURING ELECTROCHEMICAL DEVICE

    Hiromitsu Kawase, Yuu Zama, Okitoshi Kimura, Kohji Matsuoka, Ryuji Higashi, Yusuke Kanno, Hideo Yanagita, Masahiro Masuzawa

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    Application no:17176496 

    Patent/Registration no:US11807783  Date registered:2023.11 

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  • ELECTRODE, ELECTRODE ELEMENT, NON-AQUEOUS ELECTROLYTE STORAGE ELEMENT

    KAWASE HIROMITSU, ZAMA YOU, KIMURA OKITOSHI, YANAGIDA HIDEO, HIROWATARI ANNA, KANNO YUSUKE, MASUZAWA MASAHIRO, YOSHIDA AYA, TAKEUCHI SHIGEO

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    Application no:201910917031.6 

    Patent/Registration no:CN111009638  Date registered:2023.7 

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  • ELECTRODE, MANUFACTURING METHOD THEREOF, ELECTRODE COMPONENT AND NONAQUEOUS ELECTROLYTE POWER STORAGE COMPONENT

    ZANMA MASARU, YANAGITA HIDEO, HIROWATARI ANNA, YOSHIDA AYA, MASUSAWA MASAHIRO, MATSUOKA YASUJI, SUZUKI EIKO, NAKAJIMA SO, KURIYAMA HIROMICHI, KANNO YUSUKE

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    Application no:201910167307.3 

    Patent/Registration no:CN110277537  Date registered:2023.7 

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  • LIQUID COMPOSITION AND METHOD FOR PRODUCING ELECTROCHEMICAL DEVICE

    Kohji Matsuoka, Ryuji Higashi, Masahiro Masuzawa, Hideo Yanagita, Yuu Zama, Tomoya Ohmura, Yusuke Kanno, Daisuke Nose

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    Application no:16951469 

    Patent/Registration no:US11545308  Date registered:2023.1 

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  • COMPOSITE MATERIAL, ELECTRODE, ELECTRODE DEVICE, POWER STORAGE DEVICE AND METHOD OF MANUFACTURING COMPOSITE MATERIAL

    Yusuke Kanno, Hideo Yanagita, Satoshi Nakajima, Eiko Suzuki, Anna Hirowatari

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    Application no:16814299 

    Patent/Registration no:US11532811  Date registered:2022.12 

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Awards

  • Micromachines Best Paper Award

    2025.4  

    Guangchong Ji, Yusuke Kanno, Takasi Nisisako

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  • 井上研究奨励賞

    2019.2   公益財団法人 井上科学振興財団  

    菅野佑介

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  • 総長賞

    2017.3   国立大学法人 東北大学  

    菅野佑介

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  • [科学計測振興基金]多元物質科学奨励賞

    2016.12   国立大学法人 東北大学  

    菅野佑介

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  • The Chemical and Biological Microsystems Society Travel Grant -MicroTAS2016-

    2016.10  

    Yusuke Kanno

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  • 平成28年度東日本分析化学若手交流会 ポスター賞

    2016.7   公益社団法人 日本分析化学会関東支部若手の会  

    菅野佑介, 伊野浩介, 井上(安田)久美, 松平昌昭, 須田篤史, 國方亮太, 珠玖仁, 末永智一

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  • 環境科学研究科奨学賞

    2016.2   国立大学法人 東北大学  

    菅野佑介

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  • 東北分析化学奨励賞

    2015.12   日本分析化学会 東北支部  

    菅野佑介

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  • 平成26年度電気化学会論文賞

    2014.3   公益社団法人 電気化学会  

    伊野浩介, 西條拓, 菅野佑介, 小沢文智, 新井俊陽, 高橋康史, 珠玖仁, 末永智一

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  • 第27回研究会 ポスター賞

    2013.5   一般社団法人 化学とマイクロ・ナノシステム学会  

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

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  • 平成24年度化学系学協会東北大会 ポスター賞

    2012.9   公益社団法人 日本化学会東北支部  

    菅野佑介, 伊野浩介, 珠玖仁, 末永智一

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  • 工学部長賞

    2012.3   国立大学法人 東北大学  

    菅野佑介

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Research Projects

  • ナノ材料–酵素ゲルハイブリッド粒子の微細化およびバイオセンサ応用

    2025.12 - 2026.11

    公益財団法人カシオ科学振興財団  研究助成 基本テーマ1 

    菅野佑介

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    Authorship:Principal investigator 

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  • Monodisperse Protein Gel Microspheres Synthesized via Microfluidicprecursors with Controlled Spatial Dispersion

    2025.10 - 2026.9

    公益財団法人精密測定技術振興財団  国際交流等促進事業に対する助成 

    菅野佑介

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  • ナノ材料–酵素ゲルハイブリッド微粒子の量産に向けたマイクロ流体技術の創出

    2025.4 - 2027.3

    公益財団法人みずほ学術振興財団  工学研究助成 

    菅野佑介

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  • バイオセンサ応用に向けた磁場応答性酵素粒子の創製

    2024.8 - 2024.11

    公益財団法人矢崎科学技術振興記念財団  国際交流援助 

    菅野佑介

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  • オンチップでの長期細胞計測に資する磁場応答性酵素素子の創出

    Grant number:24K17706  2024.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

    菅野佑介

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  • 液滴デジタルPCRに資する簡便な液滴分取技術の開発補助事業

    2023.4 - 2024.3

    公益財団法人JKA  機械振興補助事業 若手研究 

    菅野佑介

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  • ハイドロゲル微粒子に内包した除藻剤の溶出挙動と水環境の相関性理解

    2022.10 - 2023.9

    公益財団法人クリタ水・環境科学振興財団  萌芽的研究 

    菅野佑介

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  • バイオセンサを配置した多孔膜デバイスの開発と生体模倣評価モデルへの応用

    2022.7 - 2025.3

    日本医療研究開発機構(AMED)  再生医療・遺伝子治療の産業化に向けた基盤技術開発事業(再生医療技術を応用した高度な創薬支援ツール技術開発) 

    伊野浩介

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    Authorship:Coinvestigator(s) 

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  • 極微小空間に閉じ込めた超高感度電気化学センサの創出

    Grant number:22K14707  2022.4 - 2024.3

    日本学術振興会  科学研究費助成事業  若手研究

    菅野佑介

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 電気化学センサ用磁性バイオ素子の開発

    2022.4 - 2023.3

    公益財団法人精密測定技術振興財団  調査・研究事業に対する助成 

    菅野佑介

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  • ナノ電気化学と集積回路の融合による細胞機能イメージング技術の創生

    Grant number:16J01879  2016.4 - 2017.3

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    菅野佑介

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    Grant amount:\2300000 ( Direct Cost: \2300000 )

    本研究の目的として、集積回路型電極アレイでナノ空間特有の電気化学反応を誘導する、超高感度・リアルタイム電気化学イメージングデバイスの創出を掲げた。
    電気化学デバイスの高感度化に対しては、レドックスサイクル(隣接する電極間で酸化還元反応を繰り返すシグナル増幅現象)を測定点で高効率に誘導する事でアプローチした。レドックスサイクルの効率は隣接する電極の間隔が短い程向上する。そこで、各測定点にナノ空間を設け、その空間内の上下面に電極を配置する手法を検討した。はじめにガラス基板を用いてプロトタイプを作製しその評価を行った。Pt層、Cr犠牲層(膜厚約230 nm)、Pt層および絶縁層の順で垂直方向に積層し、犠牲層をエッチングする事で高さ約230 nmのナノ空間内の上下面にPt電極を配置した。デバイスの電気化学的評価は、マウス胚性幹細胞のアルカリホスファターゼ活性の検出により行った。その結果、従来型のデバイスと比較して電流密度が約20倍向上した。これは測定点におけるナノ空間内で、高効率なレドックスサイクルが誘導された事に起因すると判断した。以上、ナノ空間内でレドックスサイクルを誘導する本デバイスは、従来型と比較して高感度な電気化学計測が可能であり細胞解析に十分適用できると考えられる。
    本研究では、集積回路型電極アレイの超高感度化に向けて電極構造の基礎検討を遂行した。今後、上記成果を集積回路型電極アレイへフィードバックする事で、細胞機能をリアルタイムかつ超高感度に可視化できる革新的なイメージング技術へ発展すると期待できる。また、今回は実現まで至らなかったが、細胞を用いた疾患治療薬スクリーニングへの応用も期待できる。

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Teaching Experience

  • メカノサイエンス実験PJ (東京科学大学)

    2025

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  • 機械系基礎実験

    2024 Institution:東京科学大学

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  • 機械系基礎実験

    2023 Institution:Tokyo Institute of Technology

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Social Activities

  • 動物実験代替法チャレンジコンテスト2025

    Role(s): Organizing member

    一般社団法人日本動物実験代替法学会 3Rs 啓発委員会  2025.8

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  • 動物実験代替法チャレンジコンテスト2024

    Role(s): Organizing member

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