Organization
School of Science Assistant Professor
Title
Assistant Professor
External link
KUWANO SATORU
Degree
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博士（薬学） ( 京都大学 )
Research Interests
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有機元素化学
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有機反応化学
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触媒化学
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不斉合成
Research Areas
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Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry
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Nanotechnology/Materials / Synthetic organic chemistry
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Catalyst and resource chemical process
Research History
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Institute of Science Tokyo Assistant Professor
2024.10
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Tokyo Institute of Technology School of Science Assistant Professor
2020.5 - 2024.9
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Chiba University Graduate School of Science
2015.11 - 2020.4
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Daiichi University, College of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Assistant Professor
2014.4 - 2015.10
Professional Memberships
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THE PHARMACEUTICAL SOCIETY OF JAPAN
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THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN
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THE CHEMICAL SOCIETY OF JAPAN
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ヨウ素学会
Papers
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Reusable Selenenyl Iodide-Initiated Cascade Cyclization of Polyenes with N-terminating Groups
Satoru Kuwano, Jun Kikushima, Takaaki Nakada, Shohei Sase, Kei Goto
CHEMISTRY-AN ASIAN JOURNAL 20 ( 14 ) 2025.7
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Highly Electrophilic Intermediates in the Bypass Mechanism of Glutathione Peroxidase: Synthesis, Reactivity, and Structures of Selenocysteine-Derived Cyclic Selenenyl Amides Reviewed
Ryosuke Masuda, Takafumi Karasaki, Shohei Sase, Satoru Kuwano, Kei Goto
Chemistry - A European Journal 29 ( 71 ) 2023.12
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Remote Electronic Effect of Chiral N-Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction Reviewed
Tsubasa Inokuma, Kentaro Hashimoto, Tatsuya Fujiwara, Chunzhao Sun, Satoru Kuwano, Ken ichi Yamada
Chemistry - A European Journal 29 ( 38 ) 2023.7
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Modeling Selenoprotein Se-Nitrosation: Synthesis of a Se-Nitrososelenocysteine with Persistent Stability Reviewed
Ryosuke Masuda, Satoru Kuwano, Kei Goto
Journal of the American Chemical Society 145 ( 26 ) 14184 - 14189 2023.7
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Satoru Kuwano, Erika Takahashi, Jun Kikushima, Shohei Sase, Kei Goto
New Journal of Chemistry 47 ( 20 ) 9569 - 9574 2023.3
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Tsubasa Inokuma, Kohei Iritani, Yuki Takahara, Chunzhao Sun, Yousuke Yamaoka, Satoru Kuwano, Ken-ichi Yamada
Chemical Communications 59 ( 36 ) 5375 - 5378 2023
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Stable cysteine sulfenic acid: synthesis by direct oxidation of a thiol, crystallographic analysis, and elucidation of reactivities Invited Reviewed
Kei Goto, Tsukasa Sano, Ryosuke Masuda, Shotaro Otaka, Ryutaro Kimura, Shohei Sase, Satoru Kuwano
Phosphorus, Sulfur and Silicon and the Related Elements 198 ( 6 ) 466 - 470 2023
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Kinetic Resolution of α‐Hydroxyamide via N‐Heterocyclic Carbene‐Catalyzed Acylation Reviewed
Ken‐ichi Yamada, Akiho Yamauchi, Tatsuya Fujiwara, Keiji Hashimoto, Yinli Wang, Satoru Kuwano, Tsubasa Inokuma
Asian Journal of Organic Chemistry 11 ( 10 ) 2022.9
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Model Study on the Catalytic Cycle of Glutathione Peroxidase Utilizing Selenocysteine-Containing Tripeptides: Elucidation of the Protective Bypass Mechanism Involving Selenocysteine Selenenic Acids Reviewed
Ryosuke Masuda, Satoru Kuwano, Shohei Sase, Marco Bortoli, Andrea Madabeni, Laura Orian, Kei Goto
Bulletin of the Chemical Society of Japan 95 ( 9 ) 1360 - 1379 2022.9
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Yinli Wang, Akiho Yamauchi, Keiji Hashimoto, Tatsuya Fujiwara, Tsubasa Inokuma, Yuta Mitani, Koichi Ute, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
ACS Catalysis 12 ( 10 ) 6100 - 6107 2022.5
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Chiral Aminomethylbinaphthol-Catalyzed Diastereo- and Enantioselective Epoxidation of Trisubstituted Acrylonitriles Reviewed
Eri Ogino, Satoru Kuwano, Takayoshi Arai
Advanced Synthesis and Catalysis 364 ( 8 ) 1503 - 1506 2022.4
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Oxy- and aminoselenation of alkenes utilizing an isolable selenenyl iodide Reviewed
Satoru Kuwano, Erika Takahashi, Kazuaki Ebisawa, Yo Ishikawa, Shohei Sase, Kei Goto
Mendeleev Communications 32 ( 1 ) 80 - 82 2022.3
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Late-Stage Functionalization of the Periphery of Oligophenylene Dendrimers with Various Arene Units via Fourfold C-H Borylation Reviewed
Ryosuke Masuda, Satoru Kuwano, Kei Goto
Journal of Organic Chemistry 86 ( 21 ) 14433 - 14443 2021.11
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Enantio- and diastereoselective double Mannich reaction of malononitrile with N-Boc imines using quinine-derived bifunctional organoiodine catalyst. Reviewed International journal
Satoru Kuwano, Eri Ogino, Takayoshi Arai
Organic & Biomolecular Chemistry 19 ( 32 ) 6969 - 6973 2021.8
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A Hypervalent Cyclic Dibenzoiodolium Salt as a Halogen-Bond-Donor Catalyst for the [4+2] Cycloaddition of 2-Alkenylindoles. Reviewed International journal
Yuki Nishida, Takumi Suzuki, Yuri Takagi, Emi Amma, Ryoya Tajima, Satoru Kuwano, Takayoshi Arai
ChemPlusChem 86 ( 5 ) 741 - 744 2021.4
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Chiral C2-Symmetric Aminomethylbinaphthol as Synergistic Catalyst for Asymmetric Epoxidation of Alkylidenemalononitriles: Easy Access to Chiral Spirooxindoles. Reviewed International journal
Eri Ogino, Ayu Nakamura, Satoru Kuwano, Takayoshi Arai
Organic Letters 23 ( 6 ) 1980 - 1985 2021.2
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Catalytic Asymmetric Chlorination of β-Ketoesters Using N-PFB-PyBidine-Zn(OAc)2 Reviewed
Ma, J., Suzuki, T., Kuwano, S., Arai, T.
Catalysts 10 ( 10 ) 1177 - 1185 2020.10
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Nakamura, A., Kuwano, S., Sun, J., Araseki, K., Ogino, E., Arai, T.
Advanced Synthesis and Catalysis 362 ( 15 ) 3105 - 3109 2020.8
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Non-Bonding Electron Pair versus pi-Electrons in Solution Phase Halogen Bond Catalysis: Povarov Reaction of 2-Vinylindoles and Imines Reviewed
Takumi Suzuki, Satoru Kuwano, Takayoshi Arai
Advanced Synthesis & Catalysis 362 ( 15 ) 3208 - 3212 2020.8
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Catalytic Asymmetric Mannich-Type Reaction of Malononitrile with N-Boc alpha-Ketiminoesters Using Chiral Organic Base Catalyst with Halogen Bond Donor Functionality Reviewed
Satoru Kuwano, Yuki Nishida, Takumi Suzuki, Takayoshi Arai
Advanced Synthesis & Catalysis 362 ( 8 ) 1674 - 1678 2020.4
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Chiral Benzazaborole-Catalyzed Regioselective Sulfonylation of Unprotected Carbohydrate Derivatives Reviewed
Satoru Kuwano, Yusei Hosaka, Takayoshi Arai
Chemistry – A European Journal 25 ( 56 ) 12920 - 12923 2019.10
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Bis(imidazolidine)pyridine-CoCl2: A Novel, Catalytically Active Neutral Complex for Asymmetric Michael Reaction of 1,3-Carbonyl Compounds with Nitroalkenes Reviewed
Takayoshi Arai, Yuko Iimori, Mayu Shirasugi, Ryota Shinohara, Yuri Takagi, Takumi Suzuki, Junma Ma, Satoru Kuwano, Hyuma Masu
Advanced Synthesis & Catalysis 361 ( 16 ) 3704 - 3711 2019.8
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Catalysis Based on C−I⋅⋅⋅π Halogen Bonds: Electrophilic Activation of 2‐Alkenylindoles by Cationic Halogen‐Bond Donors for [4+2] Cycloadditions
Satoru Kuwano, Takumi Suzuki, Masahiro Yamanaka, Ryosuke Tsutsumi, Takayoshi Arai
Angewandte Chemie 131 ( 30 ) 10326 - 10330 2019.7
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Catalysis Based on C-I pi Halogen Bonds: Electrophilic Activation of 2-Alkenylindoles by Cationic Halogen-Bond Donors for [4+2] Cycloadditions Reviewed
Satoru Kuwano, Takumi Suzuki, Masahiro Yamanaka, Ryosuke Tsutsumi, Takayoshi Arai
Angewandte Chemie International Edition 58 ( 30 ) 10220 - 10224 2019.7
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Chiral benzazaboroles as catalysts for enantioselective sulfonylation of cis-1,2-diols Reviewed
Satoru Kuwano, Yusei Hosaka, Takayoshi Arai
Organic & Biomolecular Chemistry 17 ( 18 ) 4475 - 4482 2019.5
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2-IODOIMIDAZOLINIUM SALT-CATALYZED FRIEDEL-CRAFTS REACTION: SYNTHESIS OF BIS(INDOLYL)METHANE ALKALOIDS Reviewed
Satoru Kuwano, Takumi Suzuki, Takayoshi Arai
Heterocycles 97 ( 1 ) 163 - 169 2018.9
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A chiral organic base catalyst with halogen-bonding-donor functionality: asymmetric Mannich reactions of malononitrile with N-Boc aldimines and ketimines Reviewed
Satoru Kuwano, Takumi Suzuki, Yusei Hosaka, Takayoshi Arai
Chemical Communications 54 ( 31 ) 3847 - 3850 2018.4
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Catalytic Asymmetric Mannich Reaction of Isatin-derived N-Boc Imines with Malononitrile by Bis(imidazolidine)-derived Pincer Rh Complex Reviewed
Takayoshi Arai, Takuya Tosaka, Satoru Kuwano
ChemistrySelect 2 ( 24 ) 7368 - 7371 2017.8
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Site-selective benzoin-type cyclization of unsymmetrical dialdoses catalyzed by N-heterocyclic carbenes for divergent cyclitol synthesis Reviewed
Bubwoong Kang, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
Chemical Communications 53 ( 32 ) 4469 - 4472 2017.4
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N-HETEROCYCLIC CARBENE-PROMOTED [3+2] CYCLOADDITION OF ALLENYL SULFONE AND ARYLIDENEMALONONITRILES Reviewed
Satoru Kuwano, Toshinobu Masuda, Koki Yamaguchi, Takayoshi Arai
Heterocycles 95 ( 1 ) 232 - 242 2017.1
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Chiral Bis(imidazolidine)iodobenzene (I-Bidine) Organocatalyst for Thiochromane Synthesis Using an Asymmetric Michael/Henry Reaction Reviewed
Takayoshi Arai, Takumi Suzuki, Takahiro Inoue, Satoru Kuwano
Synlett 28 ( 1 ) 122 - 127 2017.1
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Oxa- and Azacycle Formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene Reviewed
Yinli Wang, Raphael Oriez, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
The Journal of Organic Chemistry 81 ( 6 ) 2652 - 2664 2016.3
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N-Heterocyclic Carbene Catalyzed Monoacylation of Vicinal Diols Reviewed
Satoru Kuwano, Toshinobu Masuda
Synthesis 48 ( 4 ) 573 - 578 2016.2
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Catalytic asymmetric [3+2]-cycloaddition for stereodivergent synthesis of chiral indolyl-pyrrolidines Reviewed
Takayoshi Arai, Chihiro Tokumitsu, Tomoya Miyazaki, Satoru Kuwano, Atsuko Awata
Organic & Biomolecular Chemistry 14 ( 5 ) 1831 - 1839 2016
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N-Heterocyclic Carbene-Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives from Alditols Reviewed
Bubwoong Kang, Toshiaki Sutou, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
Advanced Synthesis & Catalysis 357 ( 1 ) 131 - 147 2015.1
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Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids Reviewed
Shingo Harada, Satoru Kuwano, Yousuke Yamaoka, Ken-ichi Yamada, Kiyosei Takasu
Angewandte Chemie International Edition 52 ( 39 ) 10227 - 10230 2013.9
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Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Cocatalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols Reviewed
Satoru Kuwano, Shingo Harada, Bubwoong Kang, Raphael Oriez, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
Journal of the American Chemical Society 135 ( 31 ) 11485 - 11488 2013.8
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Chemoselective conversion of alpha-unbranched aldehydes to amides, esters, and carboxylic acids by NHC-catalysis Reviewed
Satoru Kuwano, Shingo Harada, Raphael Oriez, Ken-ichi Yamada
Chemical Communications 48 ( 1 ) 145 - 147 2012
MISC
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システインスルフェン酸を捕まえる－化学プローブを用いた高反応性化学種の検出
鍬野 哲, 後藤 敬
月刊化学 77 ( 7 ) 70 - 71 2022.7
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不活性アルケンの自由自在なジアミノ化反応－ヨウ素触媒とクロラミン塩窒素源を活用－
鍬野 哲
月刊化学 77 ( 2 ) 60 - 61 2022.2
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速度論的に制御された“E-選択的な”オレフィンメタセシス
鍬野 哲
ファルマシア 53 ( 3 ) 260 - 260 2017.3
Awards
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平成29年度有機合成化学協会東レ研究企画賞
2017.12 公益社団法人有機合成化学協会 多価アルコールの活性化を志向したキラルアリールボロン酸触媒の創製と応用
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平成25年度笹川科学研究奨励賞
2014.4 公益財団法人日本科学協会 新規多機能型キラルカルベン触媒の開発とその応用
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日本薬学会第133年会（横浜）優秀発表賞
2013.3
Research Projects
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生体反応中間体によるπ結合活性化を基盤とする多連続複素環骨格の一挙構築
Grant number：22K05063 2022.4 - 2025.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
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ヨウ化セレネニルのヨウ素化による高反応性化学種の発生と応用
2021.4 - 2022.3
2021年度ヨウ素研究助成
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Development of straightforward molecular transformation method of unprotected carbohydrates using chiral organoboron catalyst
Grant number：19K15553 2019.4 - 2021.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Kuwano Satoru
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Although multi-step protection/deprotection methods have been used for the synthesis of sugars, in recent years, development of new one-step regioselective functionalization methods for unprotected sugars is required. In this study, we achieved regioselective functionalization of various unprotected sugars such as galactose, galactosamine, arabinose, rhamnose, and mannose in a single step using originally developed chiral organoboron catalysts. Furthermore, utilizing this method, we achieved kinetic resolution of unprotected sugars via regioselective sulfonylation.
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ハロゲン結合を基盤としたヨウ素/窒素協働作用型キラル分子性触媒の創製と応用
2019.4 - 2020.3
双葉電子記念財団平成31年度自然科学研究助成
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ハロゲン結合ドナー型キラルヨウ素触媒の創製研究
2017.4 - 2018.3
2016年度ヨウ素研究助成
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Grant number：15K18841 2015.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
Kuwano Satoru
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
The cyclic skeleton is a component included in many biologically active compounds, and the development of a novel methodology for construction of cyclic skeletons is an important research topic leading to the creation of medicines, agricultural chemicals and the like. In this research, we aimed to develop a new method for the synthesis of carbocycles using N-heterocyclic carbene (NHC)-catalyzed umpolung-type γ addition reaction. As a result of various investigations, the γ addition reaction promoted by the addition of NHC proceeded and succeeded in the synthesis of the multiply substituted cyclopentene derivative. We also found that various indole derivatives can be synthesized by using halogen bond donating type iodine catalyst induced by iodination of NHC in the process of this investigation.
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Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Cocatalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols
2013.9 - 2013.12
平成25年度第2期吉田科学技術財団国際研究集会派遣研究者助成