Updated on 2026/10/09

写真a

 
OKADA Satoshi
 
Organization
Institute of Integrated Research Laboratory for Chemistry and Life Science Associate Professor
Title
Associate Professor
External link

Degree

  • 工学博士 ( 大阪大学 )

Research Areas

  • Nanotechnology/Materials / Bio chemistry

  • Nanotechnology/Materials / Chemical biology

Education

  • 大阪大学大学院   工学研究科   生命先端工学専攻 博士課程

    2009.4 - 2012.3

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  • 大阪大学大学院   工学研究科   生命先端工学専攻 修士課程

    2007.4 - 2009.3

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  • Osaka University   School of Engineering   Department of Applied Science

    2003.4 - 2007.3

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Research History

  • Institute of Science Tokyo   Associate Professor

    2024.10

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  • National Institutes for Quantum and Radiological Science and Technology

    2024.5

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  • National Institute of Advanced Industrial Science and Technology

    2020.4 - 2025.3

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  • Tokyo Institute of Technology   Institute of Innovative Research   Associate Professor

    2020.4 - 2024.9

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  • 科学技術振興機構   さきがけ研究員（兼任）

    2018.10 - 2022.3

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  • 産業技術総合研究所   健康工学研究部門   研究員

    2018.4 - 2020.3

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  • 日本学術振興会   海外特別研究員

    2013.4 - 2015.3

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  • Massachusetts Institute of Technology

    2012.4 - 2018.3

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  • Osaka University

    2010.4 - 2012.3

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Professional Memberships

Committee Memberships

  • 日本分子イメージング学会   理事  

    2025.5   

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  • 第18回バイオ関連化学シンポジウム   実行委員  

    2023.8 - 2024.9   

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  • 第18回日本分子イメージング学会総会・学術集会   実行委員  

    2023.2 - 2024.5   

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  • ISBC2024   Scientific program committee  

    2022.12 - 2024.4   

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  • JST創発自発的な融合の場 第1回分子生命反応創発討論会   実行委員  

    2022.12 - 2023.2   

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  • 日本分子イメージング学会   事務局員  

    2017.6 - 2025.5   

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Papers

  • Cancer cell membrane-coated superparamagnetic iron oxide nanoparticles as a theranostic platform for magnetic hyperthermia and MR imaging Reviewed

    Yuchen Yuan, Satoshi Okada, Akira Sumiyoshi, Kazuki Miura, Hiroyuki Nakamura

    Bioorganic and Medicinal Chemistry   143   118787 - 118787   2026.12

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bmc.2026.118787

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  • Water‐Soluble Luminescent Trityl Radical for Fluorescence/Magnetic Resonance Dual‐Modal Imaging Probe Reviewed

    Kosuke Anraku, Satoshi Okada, Akira Sumiyoshi, Kenshiro Matsuda, Kazuhiro Nakamura, Takuya Hosokai, Ken Albrecht

    Advanced Science   2026.9

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Tris (2,4,6‐trichlorophenyl)methyl (TTM) radicals are promising scaffolds for fluorescence imaging (FI) and magnetic resonance imaging (MRI) owing to their long‐wavelength emission and intrinsic paramagnetism. Incorporating donor‐acceptor (D‐A) architectures into TTM radicals has been an established strategy to enhance the brightness and photostability of TTM radicals. However, conventional D‐A‐type TTM radicals exhibit strong charge‐transfer (CT)‐dominated emission that is easily quenched in water due to accelerated non‐radiative decay known as the energy‐gap law. Here, we report water‐soluble TTM radicals (TTM‐ tris TP3B and TTM‐ tris TP9B) which exhibit hybridized locally excited and CT character through rational modulation of the donor units and their substitution positions. New radicals exhibited high photostability and deep‐red emission with photoluminescence quantum yields of 1.4% (TTM‐ tris TP3B, 690 nm) and 1.1% (TTM‐ tris TP9B, 685 nm) in water. Their dual functionality as both fluorescent probes and MRI contrast agents was demonstrated. TTM‐ tris TP3B was taken up by living cells, localized near the cell nucleus, and showed fluorescence. The new radicals also provided a clear longitudinal relaxation time ( T 1 )‐weighted MRI contrast. This work represents the first demonstration of trityl radical functioning as practical FI/MRI dual‐modal imaging probes, establishing a molecular platform without any surfactants or metals in which the fluorophore and electron‐spin source are unified.

    DOI： 10.1002/advs.77710

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    Other Link： https://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.77710

  • A Ratiometric MRI Probe With a Tuned Crosslinked Network for Quantitative Imaging of Physiological pH Reviewed

    Ken Kato, Akira Sumiyoshi, Kyoko Katsumata, Hiroyuki Nakamura, Koichi Kato, Kazuya Kikuchi, Satoshi Okada

    Small   2026.9

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Quantitative pH imaging is important for understanding pathological tissue environments and diagnosing diseases such as tumors and inflammation. MRI‐based pH quantification has been developed based on several approaches including chemical exchange saturation transfer and ratiometric probes. However, existing approaches involve trade‐offs in sensitivity, probe complexity, and reversibility, and robust quantitative pH imaging remains challenging. Previously, we reported ratiometric MRI probes based on a simple core–shell architecture in which a gadolinium‐loaded core and a pH‐responsive hydrogel shell independently contribute to longitudinal relaxivity ( r 1 ) and transverse relaxivity ( r 2 ), respectively. These probes enabled pH quantification using r 2 / r 1 ratiometry although their pH responses were not optimized for the physiological pH range and their usable probe concentrations were limited. Here, we optimized the crosslinked network of the shell using tetraethylene glycol dimethacrylate, achieving substantial pH‐dependent changes in r 2 around physiological pH while preserving r 1 and extending the usable probe concentration range. Electron microscopy confirmed the core–shell structure and elemental distribution of the probe. The resulting probe enabled quantitative pH imaging over pH 6.0–7.5 across probe concentrations from 0.5 to 1.5 wt.%. These findings establish a practical strategy for MRI‐based pH quantification, offering a step toward standardized non‐invasive pH measurements.

    DOI： 10.1002/smll.75796

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.75796

  • Remote-Loaded Boron Liposomes: Cell Membrane Interfaces for Enhanced Cellular Association in Boron Neutron Capture Therapy Reviewed

    Yuchen Yuan, Satoshi Okada, Kazuki Miura, Minoru Suzuki, Hiroyuki Nakamura

    Langmuir   42 ( 29 )   21236 - 21244   2026.7

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    Abstract

    Efficient delivery of boron is a critical determinant of the therapeutic efficacy of boron neutron capture therapy (BNCT). However, conventional boron-loaded liposomal systems often suffer from low encapsulation efficiency (EE), resulting in a significant loss of costly 10B-enriched compounds and limited practical applicability. In this study, we established a remote loading strategy for the efficient encapsulation of boron compounds into liposomes. By employing a transmembrane ion gradient, boron-encapsulated liposomes (BLPs) were prepared with an encapsulation efficiency of 42.1% and a boron-to-phospholipid (B/P) ratio of 2, demonstrating the feasibility of remote loading for boron delivery. To further enhance liposome–cell interactions, BLPs were modified with cancer cell membrane interfaces derived from MDA-MB-231 cells. The resulting CM-BLPs exhibited significantly enhanced cellular association, achieving a boron accumulation of 125 ng[B]/106 cells, and showed stable retention without detectable leakage under physiological conditions. In vitro BNCT irradiation experiments revealed that CM-BLPs exhibited greater therapeutic efficacy than both unmodified BLPs and 4-borono-l-phenylalanine (BPA). These results demonstrate the feasibility of remote loading as a practical and scalable strategy for boron delivery in BNCT with cell membrane interfaces serving as a complementary approach to enhance cellular interactions.

    DOI： 10.1021/acs.langmuir.6c02188

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    Other Link： https://pubs.acs.org/langd5/article-pdf/42/29/21236/65985999/acs.langmuir.6c02188.pdf

  • Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

    Kotaro Fujishiro, Satoshi Okada, Filippo Rossi, Takahiro Kuchimaru, Yuta Kurashina

    Advanced Science   2026.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    <jats:title>ABSTRACT</jats:title>
    <jats:p>Reactive Oxygen Species (ROS), which play a critical role in cellular signaling pathways, are one of the chemical products caused by ultrasound irradiation. In general, ROS generation has been ignored in terms of high‐frequency ultrasound (&gt;5 MHz) due to the limitation of cavitation induction. However, does high‐frequency ultrasound not affect the production of ROS in cells? Here, we propose comparing ROS in solution and intracellular ROS generation by ultrasound at high frequency (6.5 MHz) and at a common frequency (1 MHz) in medical ultrasound applications, thereby elucidating the capabilities of high‐frequency ultrasound on cells by ROS production. We discovered that 6.5 MHz ultrasound, as irradiated by a lithium niobate transducer, generates intracellular ROS more than conventional 1.0 MHz ultrasound. The phenomenon of ROS production by high‐frequency ultrasound having high spatial resolution demonstrated the possibility that ultrasound is capable of effectively generating intracellular ROS at the cellular level.</jats:p>

    DOI： 10.1002/advs.202519582

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  • Alanine-serine-cysteine transporter-targeted small-molecule boron carriers for neutron capture therapy of L-4‑boronophenylalanine-refractory tumors

    Kazuki Miura, Tomoyuki Araki, Taiki Morita, Kai Nishimura, Satoshi Okada, Minoru Suzuki, Hiroyuki Nakamura

    Journal of Controlled Release   2026.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jconrel.2025.114566

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  • Magnetically Triggered Drug-Release System and Magnetic Caged Calcium Using Iron Oxide Nanoparticles and Hydrogels Reviewed

    Satoshi Okada, Yuka Takashima, Hiroyuki Nakamura

    ACS Applied Polymer Materials   2025.4

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsapm.5c00652

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  • BODIPY-Based Photothermal Agent Incorporating Azulene for Enhanced NIR Absorption and Tumor Ablation

    Kai Nishimura, Mikiya Kato, Tomoya Fukui, Kazuki Miura, Masato Tsuda, Satoshi Okada, Takanori Fukushima, Hiroyuki Nakamura

    Molecular Pharmaceutics   2025.4

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.molpharmaceut.5c00071

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  • Discovery of niclosamide as a p300/transcription factor protein–protein interaction inhibitor Reviewed

    Dhina Fitriastuti, Kazuki Miura, Satoshi Okada, Hiroyuki Hirano, Hiroyuki Osada, Hiroyuki Nakamura

    Bioorganic & Medicinal Chemistry   121   118114 - 118114   2025.2

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bmc.2025.118114

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  • A Water-Soluble Small Molecule Boron Carrier Targeting Biotin Receptors for Neutron Capture Therapy Reviewed

    Kai Nishimura, Shota Tanaka, Kazuki Miura, Satoshi Okada, Minoru Suzuki, Hiroyuki Nakamura

    ACS Omega   9 ( 52 )   51631 - 51640   2024.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsomega.4c09388

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  • A water-soluble luminescent tris(2,4,6-trichlorophenyl)methyl radical-carbazole dyad Reviewed

    Kosuke Anraku, Kenshiro Matsuda, Satoshi Miyata, Hikaru Ishii, Takuya Hosokai, Satoshi Okada, Kazuhiro Nakamura, Kohei Nakao, Ken Albrecht

    Journal of Materials Chemistry B   12   6840 - 6846   2024

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    Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Organic luminescent radicals are a new class of materials. New water-soluble tris(2,4,6-trichlorophenyl)methyl (TTM) radicals were synthesized, and potential as fluorescence and magnetic resonance imaging agent was investigated.

    DOI： 10.1039/d4tb00940a

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  • Development of a Gadolinium–Boron-Conjugated Albumin for MRI-Guided Neutron Capture Therapy Reviewed

    Satoshi Okada, Kai Nishimura, Qarri Ainaya, Kouichi Shiraishi, Sergey A. Anufriev, Igor B. Sivaev, Yoshinori Sakurai, Minoru Suzuki, Masayuki Yokoyama, Hiroyuki Nakamura

    Molecular Pharmaceutics   20 ( 12 )   6311 - 6318   2023.11

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.molpharmaceut.3c00726

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  • Efficient neutron capture therapy of glioblastoma with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP) Reviewed

    Kai Nishimura, Hideki Kashiwagi, Taiki Morita, Yusuke Fukuo, Satoshi Okada, Kazuki Miura, Yoshitaka Matsumoto, Yu Sugawara, Takayuki Enomoto, Minoru Suzuki, Kei Nakai, Shinji Kawabata, Hiroyuki Nakamura

    Journal of Controlled Release   360   249 - 259   2023.8

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jconrel.2023.06.022

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  • Development of a Peptide Sensor Derived from Human ACE2 for Fluorescence Polarization Assays of the SARS-CoV-2 Receptor Binding Domain Reviewed

    Satoshi Okada, Yuka Muto, Bo Zhu, Hiroshi Ueda, Hiroyuki Nakamura

    Analytical Chemistry   2023.4

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.analchem.2c05818

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  • Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release Reviewed

    Yasuhiko Orita, Susumu Shimanuki, Satoshi Okada, Kentaro Nakamura, Hiroyuki Nakamura, Yoshitaka Kitamoto, Yusuke Shimoyama, Yuta Kurashina

    Ultrasonics Sonochemistry   94   106326 - 106326   2023.3

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ultsonch.2023.106326

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  • Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor Reviewed

    Kai Nishimura, Suzanna Harrison, Kazuki Kawai, Taiki Morita, Kazuki Miura, Satoshi Okada, Hiroyuki Nakamura

    Bioorganic & Medicinal Chemistry Letters   72   128869 - 128869   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bmcl.2022.128869

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  • Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process Reviewed International journal

    Rohmad Yudi Utomo, Satoshi Okada, Akira Sumiyoshi, Ichio Aoki, Hiroyuki Nakamura

    RSC Advances   12 ( 8 )   5027 - 5030   2022

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was developed to significantly inhibit the amyloid-β (Aβ) aggregation and detect the fibril growth by <italic>T</italic>1-weighted MR imaging.

    DOI： 10.1039/d2ra00614f

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  • Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model Reviewed International journal

    Rohmad Yudi Utomo, Atsushi Sugie, Satoshi Okada, Kazuki Miura, Hiroyuki Nakamura

    Chemical Communications   58 ( 15 )   2576 - 2579   2022

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Curcumin derivatives B and N developed as disaggregation agents of amyloid β (Aβ) fibrils significantly rescued locomotion dysfunction in an Aβ-expressing <italic>Drosophila</italic> model of Alzheimer's disease.

    DOI： 10.1039/d1cc07000b

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  • MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors Reviewed

    Satoshi OKADA, Satoko TAKAYASU, Akira SUMIYOSHI, Ichio AOKI, Hiroyuki NAKAMURA

    Analytical Sciences   37 ( 12 )   1765 - 1769   2021.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Glucose sensors for NMR relaxometry and magnetic resonance imaging (MRI) can be used for the direct measurement of glucose in turbid biological specimens. Here, we proposed a magnetic glucose sensor based on superparamagnetic iron oxide (SPIO) nanoparticles conjugated to a mannopyranoside derivative and concanavalin A (ConA). The binding of mannopyranoside groups to ConA produced a nanoparticle cluster that was dissociated by competitive binding of glucose to ConA, resulting in changes in the transverse relaxation time (T2) in a glucose-dependent manner. The sensor gave rise to significant T2 changes in physiological glucose levels of 3 - 8 mM at a nanoparticle concentration of 0.5 nM. Significant T2 responses were observed within 6 min of 5 mM glucose detection. Sensor-based MRI by a benchtop 1 tesla scanner permitted a measurement of multiple samples within 8 min. These results demonstrate that the relaxometric glucose sensor could lead to high throughput direct assay of blood samples by using a compact MRI scanner for point-of-care testing.

    DOI： 10.2116/analsci.21p082

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  • Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation Reviewed

    Yasunobu Asawa, Kei Nishida, Kazuki Kawai, Kiyotaka Domae, Hyun Seung Ban, Akihiro Kitazaki, Hiroya Asami, Jun-Ya Kohno, Satoshi Okada, Hiraku Tokuma, Daisuke Sakano, Shoen Kume, Masaru Tanaka, Hiroyuki Nakamura

    Bioconjugate Chemistry   2021.10

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.bioconjchem.1c00431

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  • Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach Reviewed

    Rohmad Yudi Utomo, Yasunobu Asawa, Satoshi Okada, Hyun Seung Ban, Atsushi Yoshimori, Jürgen Bajorath, Hiroyuki Nakamura

    Bioorganic & Medicinal Chemistry   46   116357 - 116357   2021.9

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bmc.2021.116357

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  • Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy Reviewed International journal

    Kazuki Kawai, Kai Nishimura, Satoshi Okada, Shinichi Sato, Minoru Suzuki, Takushi Takata, Hiroyuki Nakamura

    Molecular Pharmaceutics   17 ( 10 )   3740 - 3747   2020.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    Cyclic RGD (cRGD) peptide-conjugated boronated albumin was developed to direct toward integrin αvβ3, which overexpresses on many cancer cells. A stepwise conjugation of c[RGDfK(Mal)] and maleimide-conjugated closo-dodecaborate (MID) to bovine serum albumin (BSA) afforded cRGD-MID-BSA, which was noncytotoxic toward both U87MG and A549 cells. As compared with l-BPA, selective antitumor activity of cRGD-MID-BSA toward U87MG cells overexpressing integrin αvβ3 was identified after thermal neutron irradiation. In vivo fluorescence live imaging of Cy5-conjugated cRGD-MID-BSA and MID-BSA revealed that both cRGD-MID-BSA and MID-BSA similarly reached the maximum accumulation during 8-12 h after injection. The selective accumulation and retention of Cy5-cRGD-MID-BSA was more pronounced than Cy5-MID-BSA after 24 h. An in vivo boron neutron capture therapy (BNCT) study revealed that the cRGD peptide ligand combination enhanced accumulation of MID-BSA into tumor cells in U87MG xenograft models. The significant tumor growth suppression was observed in U87MG xenograft models at a dose of 7.5 mg [10B]/kg after neutron irradiation.

    DOI： 10.1021/acs.molpharmaceut.0c00478

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  • Development of Neutral pH-Responsive Microgels by Tuning Cross-Linking Conditions Reviewed

    Satoshi Okada, Satoko Takayasu, Shunsuke Tomita, Yoshio Suzuki, Shinya Yamamoto

    Sensors   20 ( 12 )   3367 - 3367   2020.6

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/s20123367

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  • Neurotransmitter-Responsive Nanosensors for T2-Weighted Magnetic Resonance Imaging Reviewed

    Hsieh V, Okada S, Wei H, García-Álvarez I, Barandov A, Alvarado S R, Ohlendorf R, Fan J, Ortega A, Jasanoff A

    Journal of the American Chemical Society   141 ( 1 )   15751 - 15754   2019.10

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society ({ACS})  

    DOI： 10.1021/jacs.9b08744

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  • Calcium-dependent molecular fMRI using a magnetic nanosensor Reviewed

    Okada S, Bartelle B.B, Li N, Breton-Provencher V, Lee J.J, Rodriguez E, Melican J, Sur M, Jasanoff A

    Nature Nanotechnology   13   473 - 477   2018

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41565-018-0092-4

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Exceedingly small iron oxide nanoparticles as positive MRI contrast agents Reviewed

    He Wei, Oliver T. Bruns, Michael G. Kaul, Eric C. Hansen, Mariya Barch, Agata Wisniowska, Ou Chen, Yue Chen, Nan Li, Satoshi Okada, Jose M. Cordero, Markus Heine, Christian T. Farrar, Daniel M. Montana, Gerhard Adam, Harald Ittrich, Alan Jasanoff, Peter Nielsen, Moungi G. Bawendi

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   114 ( 9 )   2325 - 2330   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.1620145114

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • High-Performance Ferrite Nanoparticles through Nonaqueous Redox Phase Tuning Reviewed

    Ritchie Chen, Michael G. Christiansen, Alexandra Sourakov, Alan Mohr, Yuri Matsumoto, Satoshi Okada, Alan Jasanoff, Polina Anikeeva

    NANO LETTERS   16 ( 2 )   1345 - 1351   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.nanolett.5b04761

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Screen-Based Analysis of Magnetic Nanoparticle Libraries Formed Using Peptidic Iron Oxide Ligands Reviewed

    Mariya Barch, Satoshi Okada, Benjamin B. Bartelle, Alan Jasanoff

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   136 ( 36 )   12516 - 12519   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/ja410884e

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative pH Imaging Reviewed

    Satoshi Okada, Shin Mizukami, Takao Sakata, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

    ADVANCED MATERIALS   26 ( 19 )   2989 - 2992   2014.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/adma.201305018

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Magnetic nanosensors optimized for rapid and reversible self-assembly Reviewed

    Elisenda Rodriguez, Victor S. Lelyveld, Tatjana Atanasijevic, Satoshi Okada, Alan Jasanoff

    CHEMICAL COMMUNICATIONS   50 ( 27 )   3595 - 3598   2014

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/c4cc00314d

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • A nanospherical polymer as an MRI sensor without paramagnetic or superparamagnetic species Reviewed

    Satoshi Okada, Shin Mizukami, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

    DALTON TRANSACTIONS   42 ( 45 )   15864 - 15867   2013

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/c3dt50378j

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Switchable MRI contrast agents based on morphological changes of pH-responsive polymers Reviewed

    Satoshi Okada, Shin Mizukami, Kazuya Kikuchi

    BIOORGANIC & MEDICINAL CHEMISTRY   20 ( 2 )   769 - 774   2012.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bmc.2011.12.005

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Photocontrolled Compound Release System Using Caged Antimicrobial Peptide Reviewed

    Shin Mizukami, Mariko Hosoda, Takafumi Satake, Satoshi Okada, Yuichiro Hori, Toshiaki Furuta, Kazuya Kikuchi

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   132 ( 28 )   9524 - 9525   2010.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/ja102167m

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Application of a Stimuli-Responsive Polymer to the Development of Novel MRI Probes Reviewed

    Satoshi Okada, Shin Mizukami, Kazuya Kikuchi

    CHEMBIOCHEM   11 ( 6 )   785 - 787   2010.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cbic.200900649

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    Other Link： http://orcid.org/0000-0003-2776-9509

  • Design and Synthesis of Coumarin-Based Zn2+ Probes for Ratiometric Fluorescence Imaging Reviewed

    Shin Mizukami, Satoshi Okada, Satoshi Kimura, Kazuya Kikuchi

    INORGANIC CHEMISTRY   48 ( 16 )   7630 - 7638   2009.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/ic900247r

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    Other Link： http://orcid.org/0000-0003-2776-9509

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MISC

  • Development of MRI Probes for Next-Generation Therapeutics and Diagnostics Invited Reviewed

    Satoshi OKADA, Hiroyuki NAKAMUIRA

    BUNSEKI KAGAKU   74 ( 12 )   757 - 762   2025.12

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    Authorship：Lead author,　Corresponding author   Publisher：Japan Society for Analytical Chemistry  

    DOI： 10.2116/bunsekikagaku.74.757

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  • 磁気遺伝学による生体機能の制御

    岡田 智

    ファルマシア   61 ( 3 )   216 - 220   2025.3

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  • 生体分子機構解明に資するMRIプローブの開発

    岡田 智

    公益財団法人富山県ひとづくり財団機関誌「創造」   65   4 - 5   2025.3

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  • MRI誘導型ホウ素中性子捕捉療法のためのガドリニウム-ホウ素結合アルブミンの開発 Invited Reviewed

    岡田 智, 西村 開, Qarri Ainaya, 白石 貢一, 鈴木 実, 横山 昌幸, 中村 浩之

    日本分子イメージング学会機関誌   17 ( 1 )   21 - 24   2024.2

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    Authorship：Lead author  

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  • Moungi Bawendi 博士の思い出－MRI がつないだ共同研究

    岡田 智

    月刊「化学」2023年12月号   78 ( 12 )   30 - 30   2023.11

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    Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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  • Development of a curcumin-based MRI probe for detection and inhibition of amyloid β fibril growth Invited Reviewed

    Satoshi Okada, Rohmad Yudi Utomo, Akira Sumiyoshi, Ichio Aoki, Hiroyuki Nakamura

    16 ( 1 )   26 - 29   2023.2

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    Authorship：Lead author,　Corresponding author  

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  • ほ乳類細胞で発現可能な超音波イメージングのレポーター遺伝子

    岡田 智

    ファルマシア   56 ( 7 )   679 - 679   2020.7

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  • 磁性ナノ粒子とシナプトタグミンC2ドメインの 相互作用を応用したカルシウム応答型fMRI

    岡田 智

    日本化学会生体機能関連化学部会ニュースレター   34 ( 1 )   13 - 16   2019.6

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  • ナノ粒子プローブによる Ca2+依存性functional MRI Reviewed

    岡田 智, Benjamin B. Bartelle, Jiyoung Lee, Elisenda Rodriguez, James Melican, Alan Jasanoff

    日本分子イメージング学会機関誌   11 ( 1 )   34 - 37   2017.12

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  • Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative PH Imaging

    ( 42 )   29 - 31   2013

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    Language：Japanese  

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Awards

  • 奨励賞

    2024   日本分子イメージング学会  

    岡田 智

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  • 第41回「とやま賞」

    2024   富山県  

    岡田 智

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  • 優秀発表賞

    2023   第17回日本分子イメージング学会総会・学術集会  

    岡田 智

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  • 東工大挑戦的研究賞・末松特別賞

    2023   東京工業大学  

    岡田 智

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  • 優秀発表賞

    2022   第16回日本分子イメージング学会総会・学術集会  

    岡田 智

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  • 優秀講演賞（学術）

    2019   日本化学会第99春季年会  

    岡田 智

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  • FASMI Young Investigator Travel Award

    2017   第12回日本分子イメージング学会総会・学術集会  

    岡田 智

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  • 優秀発表賞

    2017   The Federation of Asian Societies for Molecular Imaging 2017  

    岡田 智

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  • Travel Stipend Award

    2016   World Molecular Imaging Congress 2016  

    岡田 智

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Research Projects

  • MRIレシオメトリーによるドーパミンの定量イメージング

    Grant number：26K22902  2026.6 - 2028.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    岡田 智, 住吉 晃

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    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

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  • Nucleus-Targeted BNCT Utilizing Endogenous Albumin as a Boron Carrier

    Grant number：25K01912  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\18850000 （ Direct Cost: \14500000 、 Indirect Cost：\4350000 ）

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  • MRIプローブによる記憶形成メカニズムの解明

    Grant number：24K01643  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    岡田 智, 中村 浩之, 三浦 一輝

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    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

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  • 磁場によるカルシウム感知受容体を介した免疫制御法の開発

    Grant number：23H04061  2023.4 - 2025.3

    日本学術振興会  科学研究費助成事業  学術変革領域研究(A)

    岡田 智

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    Grant amount：\7800000 （ Direct Cost: \6000000 、 Indirect Cost：\1800000 ）

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  • 神経活動履歴を可視化する磁性ナノプローブの開発

    Grant number：22K19103  2022.6 - 2024.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    岡田 智, 中村 浩之, 三浦 一輝, 盛田 大輝

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    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

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  • Development of 3D skeleton compound library targeting protein-protein interaction

    Grant number：22K19104  2022.6 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

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  • 磁性分子による脳階層構造の統合解析

    Grant number：21460834  2022 - 2028

    科学技術振興機構  戦略的な研究開発の推進/創発的研究支援事業

    岡田 智

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    脳の機能は、シナプス結合、神経回路、脳領域などに分かれた階層構造によって統合されています。本研究では、複数の異なる神経活動を磁気共鳴イメージングで同時に検出したり、特定の神経回路のみを磁場で活性化したりする磁性分子の創出を目指します。開発した磁性分子によって、脳の異なった階層間で起こる活動の相関を明らかにし、個々の思考や行動を予測・制御する技術シーズの確立につなげます。

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  • 腸管免疫系の機能解明を志向した磁場による細胞外カルシウム動態制御法の開発

    Grant number：21H05514  2021.9 - 2023.3

    日本学術振興会  科学研究費助成事業  学術変革領域研究(A)

    岡田 智

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    Grant amount：\7800000 （ Direct Cost: \6000000 、 Indirect Cost：\1800000 ）

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  • Development of Endogenous Albumin-Based Novel Boron Delivery System

    Grant number：23K21154  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\17160000 （ Direct Cost: \13200000 、 Indirect Cost：\3960000 ）

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  • Development of Endogenous Albumin-Based Novel Boron Delivery System

    Grant number：21H02066  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\17160000 （ Direct Cost: \13200000 、 Indirect Cost：\3960000 ）

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  • 磁性ナノプローブによる高感度全脳機能イメージング

    2019.4 - 2021.3

    日本学術振興会  若手研究 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • 神経伝達を経路特異的に可視化する磁性ナノプローブの開発

    2019.1 - 2019.12

    光科学技術研究振興財団  平成30年度研究助成 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • 磁場照射で脳機能を観察・操作する磁性ナノツールの開発

    2018.10 - 2022.3

    科学技術振興機構（JST）  さきがけ 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • 分子レベルで神経活動を可視化するMRIプローブの開発

    2018.8 - 2020.3

    日本学術振興会  研究活動スタート支援 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • DNAナノテクノロジーを応用したMRIプローブの開発

    2013.4 - 2015.3

    日本学術振興会  海外特別研究員 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • 脳機能イメージング用MRI造影剤の開発

    2012.4 - 2013.3

    上原記念生命科学財団  ポストドクトラルフェローシップ 

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

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  • 刺激応答性ポリマーを応用した新規MRIプローブの開発

    Grant number：10J00279  2010.4 - 2012.3

    日本学術振興会  特別研究員（DC2）  特別研究員奨励費

    岡田 智

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    Authorship：Principal investigator  Grant type：Competitive

    分子イメージングは、生体分子の挙動・機能を直接可視化できるため、多くの生物学的知見をもたらしてきた。その中でも、核磁気共鳴イメージング(MRI)は、生体深部を高い時空間分解能で可視化できるため、生物個体レベルでの観察に最適な分子イメージング法として近年注目を集めている。これまでに、酵素反応、金属イオン濃度変化、pH変化などをターゲットとする機能性MRI造影剤が開発されてきた。しかしながら、小分子化合物をベースとする機能性造影剤は、可逆的検出が困難であり低感度である。また、造影剤の局所濃度や組織由来のバックグラウンドが影響し、定量的なイメージングができない。蛍光イメージングでは、異なる2波長における蛍光強度比を測定する"レシオイメージング"によって、定量的評価が可能であるが、MRI造影剤ではそのような定量的イメージング法は未だ開発されていない。
    そこで、pH応答性ナノ球体ポリマーとGd^<3+>錯体を融合した高機能性MRI造影剤を開発した。本造影剤によって、既存の造影剤を遥かに上回る高い感度でpH変化をMRI検出できた。さらに、ナノ球体ポリマー自身が、Gd^<3+>錯体を有さずともT_2強調画像のみに影響を与えるユニークな性質を持つことを見出した。この性質を利用し、ナノ球体ポリマー内部に常磁性シリカナノ粒子を内包したコア-シェル型造影剤を開発した。その結果、MRIによるレシオ測定が達成され、定量的pHイメージングに初めて成功した。レシオ型蛍光プローブが、細胞を用いた生命科学研究に大きな進展をもたらしたように、本造影剤はin vivoにおける分子メージングのブレイクスルーとなるであろう。

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