Updated on 2026/04/28

写真a

 
ORIHARA KANAMI
 
Organization
School of Life Science and Technology Associate Professor
Title
Associate Professor
External link

Degree

  • 博士（薬学）

Research Interests

  • Allergy, Immunology

  • Chronobiology

  • Fungal Infections

Research Areas

  • Life Science / Immunology

Research History

  • Waseda University   Faculty of Science and Engineering Global Center for Science and Engineering   Assistant Professor(without tenure)

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Professional Memberships

  • Japanese Society of Allergology

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  • American Academy of Allergy, Asthma & Immunology

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  • Japanese Society for Immunology

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Papers

  • Impact of acute blue light irradiation on the molecular clock and markers associated with photoaging in skin cell models

    Agnia Vibriani, Xinyue Chen, Susumu Kajiwara, Kanami Orihara

    Journal of Molecular Medicine   2026.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00109-026-02664-y

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  • Fungal Reactive Oxygen Species Secreted by Candida albicans Induce Barrier Disruption and Cell Death in HaCaT Keratinocytes

    Jayshree Low Jit Sze, Xinyue Chen, Kanami Orihara, Susumu Kajiwara

    Journal of Fungi   12 ( 1 )   38 - 38   2026.1

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Candida albicans is a pathogenic fungus that expresses a fungal NADPH oxidase known as C. albicans Cfl11, which produces reactive oxygen species (ROS). Secretion of these ROS triggers caspase 3–mediated cell death in hepatocytes, which was attenuated in a mutant with a disrupted CaCFL11 gene (designated Cacfl11Δ mutant). Here, we compared the effects of the C. albicans wild-type strain and the Cacfl11Δ mutant. Our findings revealed that C. albicans reduces the viability of HaCaT keratinocytes in a contact-independent manner. Furthermore, exposure to C. albicans increased intracellular ROS production and caspase 3 activity in HaCaT keratinocytes. These changes were attenuated when HaCaT keratinocytes were exposed to the Cacfl11Δ mutant or when HaCaT keratinocytes were treated with the known antioxidant N-acetylcysteine. Furthermore, wild-type C. albicans, but not the Cacfl11Δ mutant, disrupted transepithelial electrical resistance and modulated the downregulation of the tight-junction genes occludin and junction adhesion molecule 1 in HaCaT keratinocytes. Collectively, these results show that fungal ROS secretion via CaCFL11 is a potent virulence factor in mediating keratinocyte viability and barrier function.

    DOI： 10.3390/jof12010038

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  • Blue Light Exposure Disrupts Circadian Rhythms and Accelerates Skin Photoaging through Coordinated Cellular and Molecular Mechanisms

    Agnia Vibriani, Xinyue Chen, Susumu Kajiwara, Kanami Orihara

    2025.12

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  • Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence

    Shiela Marie Gines Selisana, Xinyue Chen, Eny Mahfudhoh, Anom Bowolaksono, Anna Rozaliyani, Kanami Orihara, Susumu Kajiwara

    Medical Microbiology and Immunology   2024.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00430-024-00795-y

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  • Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation

    Yao Du, Xinyue Chen, Susumu Kajiwara, Kanami Orihara

    Nutrients   2024.7

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/nu16142263

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  • Protective Effects of Inulin on Stress-Recurrent Inflammatory Bowel Disease. International journal

    Yao Du, Kanta Kusama, Koki Hama, Xinyue Chen, Yu Tahara, Susumu Kajiwara, Shigenobu Shibata, Kanami Orihara

    International journal of molecular sciences   25 ( 5 )   2024.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the digestive tract and is closely associated with the homeostasis of the gut microbiota. Inulin, as a natural prebiotic, displays anti-inflammatory activity and maintains equilibrium of the intestinal microbiota. In this study, our research aimed to explore the potential of inulin in enhancing intestinal immunity and reducing inflammation in stress-recurrent IBD. In this study, a co-culture intestinal epithelium model and a stress-recurrent IBD mouse model was used to examine the protective effects of inulin. It was observed that inulin digesta significantly reduced pro-inflammatory cytokine expression (CXCL8/IL8 and TNFA) and increased MUC2 expression in intestinal epithelial cells. In vivo, our findings showed that Inulin intake significantly prevented IBD symptoms. This was substantiated by a decrease in serum inflammatory markers (IL-6, CALP) and a downregulation of inflammatory cytokine (Il6) in colon samples. Additionally, inulin intake led to an increase in short-chain fatty acids (SCFAs) in cecal contents and a reduction in the expression of endoplasmic reticulum (ER) stress markers (CHOP, BiP). Our results highlight that inulin can improve stress-recurrent IBD symptoms by modulating microbiota composition, reducing inflammation, and alleviating ER stress. These findings suggested the therapeutic potential of inulin as a dietary intervention for ameliorating stress-recurrent IBD.

    DOI： 10.3390/ijms25052494

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  • A Putative NADPH Oxidase Gene in Unicellular Pathogenic Candida glabrata Is Required for Fungal ROS Production and Oxidative Stress Response

    Maoyi Lin, Yao Huang, Kanami Orihara, Hiroji Chibana, Susumu Kajiwara, Xinyue Chen

    Journal of Fungi   2023.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/jof10010016

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  • GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions

    Mengying Lyu, Yuying Bai, Kanami Orihara, Kazuhiko Miyanaga, Naoyuki Yamamoto

    Microorganisms   2023.5

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/microorganisms11061393

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  • Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract.

    Kazuto Shiga, Atsushi Haraguchi, Hiroyuki Sasaki, Yu Tahara, Kanami Orihara, Shigenobu Shibata

    Bioscience of microbiota, food and health   42 ( 2 )   114 - 123   2023

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    Language：English   Publishing type：Research paper (scientific journal)  

    Dietary calcium supplementation has been shown to be an effective adjunct therapy in an inflammatory bowel disease model. Soluble dietary fiber reduces intestinal pH and is known to enhance calcium absorption. Although many circadian clock regulations of nutrient absorption in the intestinal tract have been reported, the effects of clock regulation on calcium absorption have yet to be understood. In this study, we investigated the timing of efficient calcium intake by measuring urinary calcium excretion in mice. The diurnal variations in channel-forming tight junctions (claudins) were detected in both the jejunum and ileum. Following 2 days of feeding with a Ca2+-free diet, Ca2+-containing diets with or without soluble fiber (inulin) were fed at specific timings, and urine was subsequently examined every 4 hr. There was an evident increase in urinary calcium concentration when the inulin diet was fed at the beginning of the resting period. The Claudin 2 (Cldn2) expression level also showed a significant day-night change, which seemed to be a mechanism for the increased calcium excretion after inulin intake. This diurnal rhythm and enhanced Cldn2 expression were abolished by disruption of the suprachiasmatic nucleus, the central clock in the hypothalamus. This study suggests that intestinal calcium absorption might be modulated by the circadian clock and that the intake of inulin is more effective at the beginning of the resting period in mice.

    DOI： 10.12938/bmfh.2022-029

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  • Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans

    Yean Sheng Lee, Xinyue Chen, Tria Widiasih Widiyanto, Kanami Orihara, Hiroyuki Shibata, Susumu Kajiwara

    Frontiers in Cellular and Infection Microbiology   12   2022.9

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    Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media {SA}  

    <jats:p><jats:italic>Candida albicans</jats:italic> is a pathogenic yeast that causes candidiasis in immunocompromised patients. The overuse of antifungal drugs has led to the development of resistance to such drugs by this fungus, which is a major challenge in antifungal chemotherapy. One approach to this problem involves the utilization of new natural products as an alternative source of antifungals. Curcumin, one such natural product, has been widely studied as a drug candidate and is reported to exhibit antifungal activity against <jats:italic>C. albicans</jats:italic>. Although studies of the mechanism of curcumin against human cancer cells have shown that it inhibits heat shock protein 90 (Hsp90), little is known about its function against <jats:italic>C. albicans</jats:italic>. In this paper, using a doxycycline-mediated <jats:italic>HSP90</jats:italic> strain and an <jats:italic>HSP90</jats:italic>-overexpressing strain of <jats:italic>C. albicans</jats:italic>, we demonstrated that the curcumin triggered a decrease in Hsp90 by affecting it at the post-transcriptional level. This also led to the downregulation of <jats:italic>HOG1</jats:italic> and <jats:italic>CDR1</jats:italic>, resulting in a reduction of the stress response and efflux pump activity of <jats:italic>C. albicans</jats:italic>. However, the inhibition of <jats:italic>HSP90</jats:italic> by curcumin was not due to the inhibition of transcription factors <jats:italic>HSF1</jats:italic> or <jats:italic>AHR1</jats:italic>. We also found that curcumin can not only decrease the transcriptional expression of <jats:italic>CDR1</jats:italic>, but also inhibit the efflux pump activity of Cdr1. Hence, we conclude that disruption of <jats:italic>HSP90</jats:italic> by curcumin could impair cell growth, stress responses and efflux pump activity of <jats:italic>C. albicans</jats:italic>.</jats:p>

    DOI： 10.3389/fcimb.2022.944611

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  • Regulating peripheral clocks to restore skin immunity.

    Kanami Orihara

    アレルギーの臨床   2022.8

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  • Skin and immune cells crosstalk via circadian regulations

    Kanami Orihara

    Exploration of Immunology   285 - 294   2021.10

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    Publishing type：Research paper (scientific journal)   Publisher：Open Exploration Publishing  

    DOI： 10.37349/ei.2021.00019

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  • Regulating peripheral clocks to prevent allergy exacerbation

    Kanami Orihara

    アレルギーの臨床   2021.8

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  • Applying our body clock to regulating allergic inflammation

    Kanami Orihara

    Medical Science Digest   2021.7

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  • Crosstalk Among Circadian Rhythm, Obesity and Allergy. International journal

    Kanami Orihara, Atsushi Haraguchi, Shigenobu Shibata

    International journal of molecular sciences   21 ( 5 )   2020.3

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    The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.

    DOI： 10.3390/ijms21051884

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  • Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans

    Orihara, K., Odemuyiwa, S. O., Stefura, W. P., Ilarraza, R., HayGlass, K. T., Moqbel, R.

    Immunology   153 ( 3 )   2018

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/imm.12846

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  • Food protein-induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features Reviewed

    Hideaki Morita, Hiroko Suzuki, Kanami Orihara, Kenichiro Motomura, Akio Matsuda, Yukihiro Ohya, Hirohisa Saito, Ichiro Nomura, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   140 ( 6 )   1718 - +   2017.12

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  • Gene Expression Patterns in Distinct Endoscopic Findings for Eosinophilic Gastritis in Children Reviewed

    Masamichi Sato, Tetsuo Shoda, Hirotaka Shimizu, Kanami Orihara, Kyoko Futamura, Akio Matsuda, Yoshiyuki Yamada, Rie Irie, Takako Yoshioka, Toshiaki Shimizu, Yukihiro Ohya, Ichiro Nomura, Kenji Matsumoto, Katsuhiro Arai

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE   5 ( 6 )   1639 - +   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jaip.2017.03.030

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  • Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice

    Wada, M., Orihara, K., Kamagata, M., Hama, K., Sasaki, H., Haraguchi, A., Miyakawa, H., Nakao, A., Shibata, S.

    Sci Rep   7 ( 1 )   8802 - 8802   2017

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-09438-0

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  • Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels. International journal

    Shoda T, Matsuda A, Arai K, Shimizu H, Morita H, Orihara K, Okada N, Narita M, Ohya Y, Saito H, Matsumoto K, Nomura I

    J Allergy Clin Immunol.   Epub ahead of print ( 1 )   299 - 303   2016.7

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  • Controlling the peripheral clock might be a new treatment strategy in allergy and immunology

    Kanami Orihara, Hirohisa Saito

    Journal of Allergy and Clinical Immunology   137 ( 4 )   1236 - 1237   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Mosby Inc.  

    DOI： 10.1016/j.jaci.2015.08.054

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  • Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation

    Tetsuo Shoda, Kyoko Futamura, Kanami Orihara, Maiko Emi-Sugie, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda

    Allergology International   65 ( 1 )   21 - 29   2016.1

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    Language：English   Publisher：Japanese Society of Allergology  

    DOI： 10.1016/j.alit.2015.08.001

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  • Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. International journal

    Kana Tanabe, Eri Kitagawa, Misaki Wada, Atsushi Haraguchi, Kanami Orihara, Yu Tahara, Atsuhito Nakao, Shigenobu Shibata

    Scientific reports   5 ( 14424 )   14424 - 14424   2015.9

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    The mammalian circadian clock controls many physiological processes that include immune responses and allergic reactions. Several studies have investigated the circadian regulation of intestinal permeability and tight junctions known to be affected by cytokines. However, the contribution of circadian clock to food allergy symptoms remains unclear. Therefore, we investigated the role of the circadian clock in determining the severity of food allergies. We prepared an ovalbumin food allergy mouse model, and orally administered ovalbumin either late in the light or late in the dark period under light-dark cycle. The light period group showed higher allergic diarrhea and weight loss than the dark period group. The production of type 2 cytokines, IL-13 and IL-5, from the mesenteric lymph nodes and ovalbumin absorption was higher in the light period group than in the dark period group. Compared to the dark period group, the mRNA expression levels of the tight junction proteins were lower in the light period group. We have demonstrated that increased production of type 2 cytokines and intestinal permeability in the light period induced severe food allergy symptoms. Our results suggest that the time of food antigen intake might affect the determination of the severity of food allergy symptoms.

    DOI： 10.1038/srep14424

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  • NMDA receptors mediate contractile responses in human airway smooth muscle cells

    Anaparti, V., Ilarraza, R., Orihara, K., Stelmack, G. L., Ojo, O. O., Mahood, T. H., Unruh, H., Halayko, A. J., Moqbel, R.

    Am J Physiol Lung Cell Mol Physiol   308 ( 12 )   L1253 - L1264   2015

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    DOI： 10.1152/ajplung.00402.2014

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  • MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major

    Zhirong Mou, Dong Liu, Ifeoma Okwor, Ping Jia, Kanami Orihara, Jude Ezeh Uzonna

    PLOS PATHOGENS   10 ( 9 )   2014.9

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    DOI： 10.1371/journal.ppat.1004396

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  • Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)2. International journal

    Hideaki Morita, Ichiro Nomura, Kanami Orihara, Koichi Yoshida, Akira Akasawa, Hiroshi Tachimoto, Yoshikazu Ohtsuka, Yoshiyuki Namai, Masaki Futamura, Tetsuo Shoda, Akio Matsuda, Norio Kamemura, Hiroshi Kido, Takao Takahashi, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto

    The Journal of allergy and clinical immunology   131 ( 2 )   590 - 2   2013.2

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  • IL-33 mediates inflammatory responses in human lung tissue cells

    Akiko Yagami, Kanami Orihara, Hideaki Morita, Kyoko Futamura, Noriko Hashimoto, Kenji Matsumoto, Hirohisa Saito, Akio Matsuda

    Journal of Immunology   185 ( 10 )   5743 - 5750   2010.11

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    DOI： 10.4049/jimmunol.0903818

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  • What's new in asthma pathophysiology and immunopathology?

    Orihara, K., Dil, N., Anaparti, V., Moqbel, R.

    Expert Rev Respir Med   4 ( 5 )   605 - 629   2010

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1586/ers.10.57

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  • beta(2)-Adrenoceptor Agonists Enhance Cytokine-Induced Release of Thymic Stromal Lymphopoietin by Lung Tissue Cells

    Kyoko Futamura, Kanami Orihara, Noriko Hashimoto, Hideaki Morita, Shuhei Fukuda, Hironori Sagara, Kenji Matsumoto, Yasushi Tomita, Hirohisa Saito, Akio Matsuda

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   152 ( 4 )   353 - 361   2010

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000288288

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  • Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack

    Yukinori Enomoto, Kanami Orihara, Tetsuya Takamasu, Akio Matsuda, Yasuhiro Gon, Hirohisa Saito, Chisei Ra, Yoshimichi Okayama

    Journal of Allergy and Clinical Immunology   124 ( 5 )   913 - e7   2009.11

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    DOI： 10.1016/j.jaci.2009.08.044

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  • TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells

    Kanami Orihara, Hideaki Morita, Akiko Yagami, Naoki Kajiwara, Susumu Nakae, Kenji Matsumoto, Hiroshi Nagasaki, Yumiko Saito, Hirohisa Saito, Akio Matsuda

    Journal of Allergy and Clinical Immunology   124 ( 3 )   612 - e2   2009.9

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  • TH2 cytokines potently induce an orexigenic peptide, melanin-concentrating hormone, in human vascular endothelial cells Reviewed

    Orihara K, Morita H, Yagami A, Kajiwara N, Nakae S, Matsumoto K, Nagasak, Saito Y, Saito H, Matsuda A

    Journal of Allergy and Clinical Immunology   124   612 - 617   2009

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  • Corticosteroid enhances TNF-α-mediated leukocyte adhesion to pulmonary microvascular endothelial cells

    A. Matsuda, K. Orihara, S. Fukuda, H. Fujinaga, K. Matsumoto, H. Saito

    Allergy: European Journal of Allergy and Clinical Immunology   63 ( 12 )   1610 - 1616   2008.12

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    DOI： 10.1111/j.1398-9995.2008.01775.x

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  • Role of regulatory and proinflammatory T-cell populations in allergic diseases

    Orihara, K., Nakae, S., Pawankar, R., Saito, H.

    World Allergy Organ J   1 ( 1 )   9 - 14   2008

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    DOI： 10.1097/wox.0b013e3181629ae3

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  • Pathophysiological roles of microvascular alterations in pulmonary inflammatory diseases: Possible implications of tumor necrosis factor-alpha and CXC chemokines

    Kanami Orihara, Akio Matsuda

    International Journal of COPD   3 ( 4 )   619 - 627   2008

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  • Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects

    Kanami Orihara, Masami Narita, Takashi Tobe, Akira Akasawa, Yukihiro Ohya, Kenji Matsumoto, Hirohisa Saito

    Journal of Allergy and Clinical Immunology   120 ( 4 )   960 - 962   2007.10

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  • Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children

    Takaharu Negoro, Kanami Orihara, Tomoko Irahara, Hiroshi Nishiyama, Kanae Hagiwara, Risa Nishida, Hiroki Takagi, Kazue Satoh, Yoshiki Yamamoto, Shunichi Shimizu, Tamio Hagiwara, Masakazu Ishii, Toshihiro Tanioka, Yasuko Nakano, Ken Takeda, Isao Yoshimura, Yoji Iikura, Takashi Tobe

    Pediatric Allergy and Immunology   17 ( 8 )   583 - 590   2006.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1399-3038.2006.00463.x

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  • Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus

    Kanami Orihara, Takashi Yamazaki, Raku Shinkyo, Toshiyuki Sakaki, Kuniyo Inouye, Akira Tsukamoto, Jun Sugiura, Kazuo Shishido

    Applied Microbiology and Biotechnology   69 ( 1 )   22 - 28   2005.11

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    DOI： 10.1007/s00253-005-1943-0

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MISC

  • Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis

    Tetsuo Shoda, Akio Matsuda, Ichiro Nomura, Naoko Okada, Kanami Orihara, Hironobu Mikami, Norihisa Ishimura, Shunji Ishihara, Kenji Matsumoto, Yoshikazu Kinoshita

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   139 ( 6 )   2010 - +   2017.6

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    DOI： 10.1016/j.jaci.2016.11.028

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  • Stool Edn Levels in Different Clusters of Non-IgE-Mediated Gastrointestinal Food Allergy

    Kanami Orihara, Ichiro Nomura, Tetsuo Shoda, Hiroko Suzuki, Hideaki Morita, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   139 ( 2 )   AB54 - AB54   2017.2

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  • Humoral immune factors in IgE- and non-IgE-mediated food allergies

    66 ( 6 )   609 - 613   2016.12

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  • Eosinophil-Related Gene Expression in Children with Eosinophilic Gastrointestinal Disorders (EGIDs)

    Tetsuo Shoda, Ichiro Nomura, Katsuhiro Arai, Hirotaka Shimizu, Yoshiyuki Yamada, Kanami Orihara, Hideaki Morita, Akio Matsuda, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   137 ( 2 )   AB280 - AB280   2016.2

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  • Clinical Characteristics of Non-IgE-Mediated Gastrointestinal Food Allergy: Analysis of Nation-Wide Web-Based Online Patient Registry

    Ichiro Nomura, Hiroko Suzuki, Tetsuo Shoda, Hideaki Morita, Kanami Orihara, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   137 ( 2 )   AB241 - AB241   2016.2

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  • Plasma Cytokine/Chemokine Profiles in Non-IgE-Mediated Gastrointestinal Food Allergy

    Kanami Orihara, Ichiro Nomura, Tetsuo Shoda, Hideaki Morita, Hiroko Suzuki, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   137 ( 2 )   AB241 - AB241   2016.2

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  • NMDA Receptor Triggering Leads CD4+T Cells Cytokine Balance Towards Type 2 Dominant

    Kanami Orihara, Kent T. HayGlass, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   135 ( 2 )   AB224 - AB224   2015.2

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  • Gene Expression Profiles of Mucosal Biopsy Specimens from Children with Eosinophilic Gastritis

    Tetsuo Shoda, Ichiro Nomura, Akio Matsuda, Kyoko Futamura, Kanami Orihara, Hideaki Morita, Katsuhiro Arai, Hirotaka Shimizu, Yoshiyuki Yamada, Masami Narita, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   135 ( 2 )   AB46 - AB46   2015.2

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  • Mucosal Biopsy Microarray Analysis Revealed Elevated Thymic Stromal Lymphopoietin (TSLP) in Infantile Eosinophilic Gastroenteritis

    Ichiro Nomura, Tetsuo Shoda, Akio Matsuda, Kanami Orihara, Hideaki Morita, Katsuhiro Arai, Hirotaka Shimizu, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   135 ( 2 )   AB39 - AB39   2015.2

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  • 毛根組織を用いた皮膚疾患の病態解析

    二村恭子, 矢上晶子, 折原芳波, 松田明生, 小島令嗣, 森田英明, 杉浦一充, 室慶直, 松永佳世子, 斎藤博久, 松本健治

    アレルギー   60 ( 9 )   1368 - 1368   2011.10

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    Language：Japanese   Publisher：(一社)日本アレルギー学会  

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  • Milk protein-specific cytokine secretion profiles in patients with food protein-related gastrointestinal disorders

    H. Morita, Nomura, I, K. Orihara, A. Matsuda, H. Saito, K. Matsumoto

    ALLERGY   66   713 - 713   2011.6

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  • Glutamate Enhances Amphiregulin (AREG) Production from Human Airway Smooth Muscle Cells

    K. Orihara, V. Anaparti, P. Sharma, A. Matsuda, K. Matsumoto, H. Saito, A. Halayko, R. Moqbel

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   127 ( 2 )   AB62 - AB62   2011.2

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  • Milk Protein-specific Cytokine Secretion Profiles In Infant Patients With Fpies And Proctocolitis

    H. Morita, I. Nomura, K. Orihara, A. Matsuda, H. Saito, K. Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   127 ( 2 )   AB216 - AB216   2011.2

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  • beta(2)-Adrenoceptor Agonists Enhance Cytokine-Induced Release of Thymic Stromal Lymphopoietin by Lung Tissue Cells

    K. Orihara, K. Futamura, H. Morita, N. Hashimoto, S. Fukuda, R. Moqbel, K. Matsumoto, H. Saito, A. Matsuda

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   125 ( 2 )   AB235 - AB235   2010.2

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  • IL-33 Mediates Inflammatory Responses in Human Airway Epithelial Cells and Microvascular Endothelial Cells

    K. Orihara, A. Yagami, H. Morita, R. Kojima, K. Matsumoto, H. Saito, A. Matsuda

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   123 ( 2 )   S73 - S73   2009.2

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  • Gene Expression Profiles of Hair Root Tissue of Atopic Dermatitis

    A. Yagami, K. Futamura, A. Matsuda, K. Orihara, N. Hashimoto, R. Kojima, H. Morita, K. Sugiura, Y. Muro, Y. Tomita, K. Matsunaga, H. Saito, K. Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   123 ( 2 )   S38 - S38   2009.2

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  • In Vitro adverse of corticosteroid on TNF-alpha-mediated responses by pulmonary microvascular endothelial cells

    K. Orihara, S. Fukuda, H. Fujinaga, K. Matsumoto, H. Saito, A. Matsuda

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   121 ( 2 )   S204 - S204   2008.2

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  • Circulating Foxp3(+)CD4(+) regulates both Th1 and Th2 responses in vivo

    K. Orihara, M. Narita, T. Tobe, A. Akasawa, Y. Ohya, K. Matsumoto, H. Saito

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   119 ( 1 )   S91 - S91   2007.1

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  • Inverse correlation between circulating CD4+CD25(high) cells and CD4(+)IL4(+) cells in vivo

    K Orihara, T Tobe, A Akasawa, H Saito, K Matsumoto

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   117 ( 2 )   S246 - S246   2006.2

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Research Projects

  • Regulating inflammatory bowel disease by controling peripheral biological clock

    Grant number：20K07535  2020.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator 

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Functional analysis of ORMDL3 related unfolded protein response in childhood-onset bronchial asthma

    Grant number：16K10053  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    FUTAMURA KYOKO, ORIHARA kanami, MATSUMOTO kenji

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    In plural genome-wide association studies, the 17th chromosome q12-21 was identified as the locus that had strong correlation with childhood-onset bronchial asthma. ORMDL3 is a dominant candidate for disease susceptibility genes. However, it remains unclear how the gene affected disease condition of bronchial asthma.
    In this study, we elucidated the mechanism that ORMDL3 molecules exacerbated bronchial inflammation through unfolded protein response during viral infection.

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  • Searching for a diagnostic marker and identification of important cell groups in non-IgE mediated gastrointestinal diseases

    Grant number：15K19580  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Orihara Kanami

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    Grant type：Competitive

    Grant amount：\3770000

    Non-IgE-mediated eosinophilic gastrointestinal diseases are the diseases that the number of patients continues to increase all over the world, pathology of which in particular in neonates to infants is difficult to distinguish from other diseases. Thus, sometimes it causes life-thretening serious complications.Therefore, in this study, we aimed to test the practical utility of the antigen-specific lymphocyte stimulation test, which is conducted at the research level at the moment, if it can be clinically applied to the diagnosis of these diseases. As a result, it was confirmed that it can be used for diagnosis, whereas weakness remains in distinguishing these diesases from IgE-mediated (normal) food allergy. I also examined cytokines and proliferating cell sub-popiulations as applied analysis versions of antigen specific lymphocyte tests, and I was able to find differences between IgE-mediated food allergy and non-IgE-mediated eosinophilic gastrointestinal diseases

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  • NMDA-R刺激によって誘導される2型T細胞特異的な生存因子の探索

    Grant number：26893291  2014.8 - 2015.3

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    折原 芳波

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1430000

    共同研究先のサポートにも恵まれ、健常成人血液を用いてPBMCおよびCD4+ T細胞を分離してアンフィレギュリンの産生に関するデータを構築した。具体的には、NMDA受容体の活性化により、アンフィレギュリン産生が誘導され、2型サイトカイン存在下ではその産生量が有意に増強された。また、NMDA受容体の作動薬の添加により、細胞活性が2型炎症の方向へ傾くことをサイトカイン・ケモカイン産生の観点から明らかにした。本研究成果は、2015年2月にアメリカ、ヒューストンにて行われた71st Annual Meeting of American Academy of Allergy, Asthma and Immunologyにて発表し、予想以上の反響を得た（Orihara K, HayGlass KT, Matsuda A, Saito H, Matsumoto K. NMDA Receptor Triggering Leads CD4+ T Cells Cytokine Balance Towards Type 2 Dominant）。このことは、アレルギー疾患の慢性化にNMDA受容体の活性化を介したアンフィレギュリン産生の系があることを示唆している。別の研究費（若手B）を採用していただいたため、本研究費の継続を辞退するこ

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  • Basic and applied studies of chrononutrition based on development of functional foods and nutrients

    Grant number：26220201  2014.5 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

    shibata shigenobu

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    Grant type：Competitive

    Grant amount：\116870000

    We could identify nobiletin, ornithine, cypress and Chinese medicine that affect the phase of the peripheral clock. The intellectual property of the functional food mentioned above acquired the joint patents. In addition to the insulin system, we have discovered the IGF-1 system, which runs on a protein diet. Coupled with the above finding, protein intake for breakfast rather than dinner is more important for skeletal muscle retention.
    In addition, intake of Jerusalem artichoke and inulin at breakfast was effective for 24-hour blood glucose control, intestinal bacteria and constipation. The chrorno-nutrition research has been carried out until the publication of recipe cards and books. We have set up a society called “Chrorno-nutrition Science Study Group” and made a social contribution. Also, the research results were press-announced twice at Waseda University, the significance of protein for breakfast was also taken up three times in NHK programs.

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  • Basic Research for a Clarification of Mechanisms and a Clinical Use to Regulate Th2 Condition by Treg Subset

    Grant number：19790704  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    ORIHARA Kanami

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    Grant type：Competitive

    Grant amount：\2400000

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