Updated on 2026/04/10

写真a

 
Nagasawa Tatsuki
 
Organization
School of Life Science and Technology Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士（理学） ( 上智大学 )

  • 修士（教育学） ( 宇都宮大学 )

Research Interests

  • 初期発生

  • レトロポゾン

  • 孵化酵素

  • 卵膜

  • ゼブラフィッシュ

  • 両生類

  • ペプシン

  • イントロン

  • 真骨魚類

Research Areas

  • Life Science / Evolutionary biology

Education

  • Sophia University   Faculty of Science & Technology   Department of Materials and Life Sciences

    2013.4 - 2016.3

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  • Utsunomiya University   The Graduate School of Education

    2011.4 - 2013.3

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  • Utsunomiya University   Faculty of Education   School Teacher Training Course

    2007.4 - 2011.3

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Research History

  • Institute of Science Tokyo   Assistant Professor

    2024.10

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    Country：Japan

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  • Tokyo Institute of Technology   School of Life Science and Technology   Assistant Professor

    2019.8 - 2024.9

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  • Jikei University   Department of Anatomy   JSPS Research Fellow

    2017.4 - 2019.7

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  • Jikei University   Department of Anatomy   Postdoctoral Researcher

    2016.4 - 2017.3

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  • 栃木県立小山南高校   非常勤講師

    2011.4 - 2012.3

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Professional Memberships

  • THE ZOOLOGICAL SOCIETY OF JAPAN

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  • SOCIETY OF EVOLUTIONARY STUDIES, JAPAN

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  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Papers

  • Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication

    Tatsuki Nagasawa, Hanami Fujisaki, Takahiro Ogo, Masato Nikaido

    2026.2

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：openRxiv  

    Whole-genome duplication (WGD) is a major evolutionary event that drives molecular and species diversification. However, few studies have traced how WGD has shaped the long-term functional evolution of individual genes. Here, we investigated the olfactory marker protein (omp) genes duplicated by the teleost-specific WGD (~300 million years ago) through phylogenetic, syntenic, expression, and promoter analyses. Our results suggest that the duplicated omp gene pair has retained redundancy over an extended evolutionary period, leading to both non- and sub-functionalization, thereby generating molecular diversity. Moreover, evolutionary analyses of the olfactory signal transduction cascade revealed prolonged redundancy across its components, likely constrained by gene dosage balance. These findings imply that WGD may have introduced unexpected diversity into the entire olfactory signaling machinery of teleosts through dosage-constrained functional divergence.

    DOI： 10.64898/2026.02.17.706259

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  • Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene

    Kanoko Nishiura, Tatsuki Nagasawa, Masato Nikaido

    Research Square   2025.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract <p> Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for survival. Through evolutionary processes, these genes have repeatedly undergone duplication, divergence, and pseudogenization, giving rise to lineage-specific gene repertoires that reflect ecological and behavioral adaptation. While the canonical functions of these chemoreceptors are confined to the nasal and oral cavities, increasing evidence, particularly in mammals, indicates that some chemoreceptors are expressed and function in non-chemosensory (extra-nasal/oral) organs. However, such extra-nasal/oral expression has rarely been examined from a broad evolutionary perspective across vertebrate lineages. Here, we systematically investigated organ-wide expression patterns of chemoreceptor genes by conducting comprehensive bulk RNA-seq analysis across 13 organs in four representative species: mouse, Xenopus , Polypterus , and zebrafish. In all species, the majority (95–97%) of chemoreceptor genes were expressed in olfactory and gustatory organs, as expected. Remarkably, however, a subset (1–29%) showed expression in extra-nasal/oral organs, suggesting that such extra-nasal/oral expression may be a common phenomenon across vertebrates. In particular, the evolutionarily conserved OR-κ gene, with stable gene copy numbers, exhibited organ-independent expression across all analyzed species. Single-cell RNA-seq data further revealed that OR-κ is predominantly expressed in immune cells, implying potential function of chemoreception in immune systems. Furthermore, genomic context analysis showed that the OR-κ gene is isolated from canonical OR gene clusters, suggesting it may have distinct transcriptional regulatory mechanisms compared to typical olfactory receptors. Our findings expand the conventional view of chemoreceptors as sensory-specialized molecules, highlighting their unexpected functional diversity across vertebrate organs. Notably, the OR-κ gene appears to have an ancient evolutionary origin that likely traces back to the common ancestor of vertebrates. Taken together, this study compels us to reconsider the functions and evolutionary trajectories of chemoreceptor genes in vertebrates. </p>

    DOI： 10.21203/rs.3.rs-8198358/v1

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    Other Link： https://www.researchsquare.com/article/rs-8198358/v1.html

  • Gluconeogenesis and glycogen metabolism during development in sterlet Acipenser ruthenus and bester Reviewed

    Marino Shimizu, Takako Matsuzaki, Kaede Kobayashi, Akihiro Aoyagi, Makiha Kaneko, Tatsuki Nagasawa, Kiyoshi Hiraoka, Fumiya Furukawa

    Fisheries Science   2025.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s12562-025-01893-3

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    Other Link： https://link.springer.com/article/10.1007/s12562-025-01893-3/fulltext.html

  • Convergent evolutionary dead-end and breakdown of hard chorion in parental-egg-care fish reproductive strategies Reviewed

    Tatsuki Nagasawa, Nagatoshi Machii, Mitsuto Aibara, Mari Kawaguchi, Shigeki Yasumasu, Masato Nikaido

    Molecular Ecology   2025.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/mec.17816

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  • Ventral-to-dorsal electrocyte development in electric organs of electric eel (Electrophorus) Reviewed

    Sinlapachai Senara, Ayako Matsumoto, Tatsuki Nagasawa, Shintaro Sakaki, Daichi Tsuzuki, Kazuko Uchida, Makoto Kuwahara, Masato Nikaido, Eiichi Hondo, Atsuo Iida

    Developmental Biology   2025.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2025.05.003

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  • Possible Involvement of Ghost Introgressions in the Striking Diversity of Vomeronasal Type 1 Receptor Genes in East African Cichlids Reviewed

    Shunsuke Taki, Zicong Zhang, Mitsuto Aibara, Tatsuki Nagasawa, Masato Nikaido

    Ecology and Evolution   2025.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Cold Spring Harbor Laboratory  

    Abstract

    Cichlids that have undergone adaptive radiation are genetically close but exhibit extreme ecological and morphological diversity, making them useful for understanding speciation mechanisms. Vomeronasal type 1 receptors (V1R) are highly conserved among teleost fish at the amino acid sequence level and believed to play a fundamental role in reproduction. We previously reported the surprisingly high sequence diversity of V1Rs among certain cichlid species, suggesting a possible role for V1Rs in their speciation. In this study, we investigated the process of evolutionary diversification of all 6 V1Rs (V1R1-6) by using the genome data of 528 cichlid species, encompassing nearly all lineages. In the case of V1R2, two highly divergent alleles (1.17%: variant sites/CDS length) without recombination were preserved and shared among cichlids found in all of the East African Great Lakes. In the case of V1R6, numerous highly variable alleles that could be derived from multiple recombination events between two highly divergent alleles (1.39%: variant sites/CDS length) were found among the Lake Victoria cichlids. Additionally, we identified highly divergent alleles of V1R1 within the tribe Tropheini, and of both V1R3 and V1R6 within Trematocarini and Ectodini. Because one of the two divergent alleles of these V1Rs emerged rapidly during cichlid evolution, they are likely to have been derived from introgression. However, despite extensive investigations, we could not identify the source lineages for these introgressions, implying that they may have become extinct. This study revealed the potential role of introgression in explaining the remarkable diversity of V1Rs in East African cichlids.

    DOI： 10.1002/ece3.71467

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  • Transglutaminase mediates the hardening of fish egg envelope produced by duplication of factor XIIIA gene during the evolution of Teleostei Reviewed

    Shigeki Yasumasu, Miyuki Horie, Mayuko Horie, Kodai Sakuma, Chihiro Sato, Hikari Sato, Taiki Nakajima, Tatsuki Nagasawa, Mari Kawaguchi, Ichiro Iuchi

    The Journal of Biochemistry   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    During the fertilization of fish eggs, the hardening of the egg envelope is mediated by transglutaminase (hTGase). After fertilization, TGase undergoes processing. We isolated hTGase from extracts of unfertilized and water-activated rainbow trout eggs. Rainbow trout hTGase (Rt-hTGase) appeared as an 80 kDa protein, and its processed form was 55 kDa. Their N-terminal amino acid sequences were nearly identical, suggesting processing in the C-terminal region. The specific activities were not significantly different, indicating that C-terminal processing does not activate the enzyme itself. We cloned the cDNA by reverse transcription polymerase chain reaction (RT-PCR) using degenerate primers followed by RACE-PCR. The deduced amino acid sequence of the cDNA was similar to that of factor XIII subunit A (FXIIIA). Molecular phylogenetic and gene syntenic analyses clearly showed that hTGase was produced by duplication of FXIIIA during the evolution to Teleostei. The 55 kDa processed form of Rt-hTGase is predominantly composed of an enzyme domain predicted from the amino acid sequence of the cDNA. It is hypothesized that the C-terminal domain of Rt-hTGase binds to egg envelope proteins, and that processing allows the enzyme to move freely within the egg envelope, increasing substrate–enzyme interaction and thereby accelerating hardening.

    DOI： 10.1093/jb/mvae062

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  • Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids Reviewed

    Nagatoshi Machii, Ryo Hatashima, Tatsuya Niwa, Hideki Taguchi, Ismael A Kimirei, Hillary DJ Mrosso, Mitsuto Aibara, Tatsuki Nagasawa, Masato Nikaido

    eLife   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：eLife Sciences Publications, Ltd  

    Cichlid fishes inhabiting the East African Great Lakes, Victoria, Malawi, and Tanganyika, are textbook examples of parallel evolution, as they have acquired similar traits independently in each of the three lakes during the process of adaptive radiation. In particular, “hypertrophied lip” has been highlighted as a prominent example of parallel evolution. However, the underlying molecular mechanisms remain poorly understood. In this study, we conducted an integrated comparative analysis between the hypertrophied and normal lips of cichlids across three lakes based on histology, proteomics, and transcriptomics. Histological and proteomic analyses revealed that the hypertrophied lips were characterized by enlargement of the proteoglycan-rich layer, in which versican and periostin proteins were abundant. Transcriptome analysis revealed that the expression of extracellular matrix-related genes, including collagens, glycoproteins and proteoglycans, was higher in hypertrophied lips, regardless of their phylogenetic relationships. In addition, the Wnt signaling pathway, which is involved in promoting proteoglycan expression, was highly expressed in both the juvenile and adult stages of hypertrophied lips. Our comprehensive analyses showed that hypertrophied lips of the three different phylogenetic origins can be explained by similar proteomic and transcriptomic profiles, which may provide important clues into the molecular mechanisms underlying phenotypic parallelisms in East African cichlids.

    DOI： 10.7554/elife.99160.1

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  • Molecular evolution of patristacin genes in teleosts based on the genome survey Reviewed

    Yuko Nakano, Tatsuki Nagasawa, Yohei Okazawa, Naoya Mashiko, Shigeki Yasumasu, Mari Kawaguchi

    Journal of Experimental Zoology Part B: Molecular and Developmental Evolution   340   414 - 423   2023.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/jez.b.23195

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  • Molecular evolution of hatching enzymes and their paralogous genes in vertebrates Reviewed

    Tatsuki Nagasawa, Mari Kawaguchi, Kohki Nishi, Shigeki Yasumasu

    BMC Ecology and Evolution   22 ( 1 )   2022.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Hatching is identified as one of the most important events in the reproduction of oviparous vertebrates. The genes for hatching enzymes, which are vital in the hatching process, are conserved among vertebrates. However, especially in teleost, it is difficult to trace their molecular evolution in detail due to the presence of other C6astacins, which are the subfamily to which the genes for hatching enzymes belong and are highly diverged. In particular, the hatching enzyme genes are diversified with frequent genome translocations due to retrocopy.

    Results

    In this study, we took advantage of the rapid expansion of whole-genome data in recent years to examine the molecular evolutionary process of these genes in vertebrates. The phylogenetic analysis and the genomic synteny analysis revealed C6astacin genes other than the hatching enzyme genes, which was previously considered to be retained only in teleosts, was also retained in the genomes of basal ray-finned fishes, coelacanths, and cartilaginous fishes. These results suggest that the common ancestor of these genes can be traced back to at least the common ancestor of the Gnathostomata. Moreover, we also found that many of the C6astacin genes underwent multiple gene duplications during vertebrate evolution, and the results of gene expression analysis in frogs implied that genes derived from hatching enzyme genes underwent neo-functionalization.

    Conclusions

    In this study, we describe in detail the molecular evolution of the C6astacin gene in vertebrates, which has not been summarized previously. The results revealed the presence of the previously unknown C6astacin gene in the basal-lineage of jawed vertebrates and large-scale gene duplication of hatching enzyme genes in amphibians. The comprehensive investigation reported in this study will be an important basis for studying the molecular evolution of the vertebrate C6astacin genes, hatching enzyme, and its paralogous genes and for identifying these genes without the need for gene expression and functional analysis.

    DOI： 10.1186/s12862-022-01966-2

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    Other Link： https://link.springer.com/article/10.1186/s12862-022-01966-2/fulltext.html

  • A Transcriptomic re-evaluation of the accessory olfactory organ in bichir (Polypterus senegalus) Reviewed

    Atsuhiro Sakuma, Zicong Zhang, Eri Suzuki, Tatsuki Nagasawa, Masato Nikaido

    Zoological letters   8 ( 5 )   2022

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Fish possess one olfactory organ called the olfactory epithelium (OE), by which various chemical substances are detected. On the other hand, tetrapods possess two independent olfactory organs called the main olfactory epithelium (MOE) and vomeronasal organ (VNO), each of which mainly detects general odorants and pheromones, respectively. Traditionally, the VNO, so-called concentrations of vomeronasal neurons, was believed to have originated in tetrapods. However, recent studies have identified a primordial VNO in lungfish, implying that the origin of the VNO was earlier than traditionally expected. In this study, we examined the presence/absence of the VNO in the olfactory organ of bichir (Polypterus senegalus), which is the most ancestral group of extant bony vertebrates. In particular, we conducted a transcriptomic evaluation of the accessory olfactory organ (AOO), which is anatomically separated from the main olfactory organ (MOO) in bichir. As a result, several landmark genes specific to the VNO and MOE in tetrapods were both expressed in the MOO and AOO, suggesting that these organs were not functionally distinct in terms of pheromone and odorant detection. Instead, differentially expressed gene (DEG) analysis showed that DEGs in AOO were enriched in genes for cilia movement, implying its additional and specific function in efficient water uptake into the nasal cavity other than chemosensing. This transcriptomic study provides novel insight into the long-standing question of AOO function in bichir and suggests that VNO originated in the lineage of lobe-finned fish during vertebrate evolution.

    DOI： 10.1186/s40851-022-00189-z

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    Other Link： https://link.springer.com/article/10.1186/s40851-022-00189-z/fulltext.html

  • Pactacin is a novel digestive enzyme in teleosts Reviewed

    Mari Kawaguchi, Yohei Okazawa, Aiko Imafuku, Yuko Nakano, Risa Shimizu, Reiji Ishizuka, Tianlong Jiang, Tatsuki Nagasawa, Junya Hiroi, Shigeki Yasumasu

    Scientific Reports   11 ( 1 )   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>Generally, animals extract nutrients from food by degradation using digestive enzymes. Trypsin and chymotrypsin, one of the major digestive enzymes in vertebrates, are pancreatic proenzymes secreted into the intestines. In this investigation, we report the identification of a digestive teleost enzyme, a pancreatic astacin that we termed pactacin. Pactacin, which belongs to the astacin metalloprotease family, emerged during the evolution of teleosts through gene duplication of astacin family enzymes containing six cysteine residues (C6astacin, or C6AST). In this study, we first cloned C6AST genes from pot-bellied seahorse (<italic>Hippocampus abdominalis</italic>) and analyzed their phylogenetic relationships using over 100 C6AST genes. Nearly all these genes belong to one of three clades: pactacin, nephrosin, and patristacin. Genes of the pactacin clade were further divided into three subclades. To compare the localization and functions of the three pactacin subclades, we studied pactacin enzymes in pot-bellied seahorse and medaka (<italic>Oryzias latipes</italic>). In situ hybridization revealed that genes of all three subclades were commonly expressed in the pancreas. Western blot analysis indicated storage of pactacin pro-enzyme form in the pancreas, and conversion to the active forms in the intestine. Finally, we partially purified the pactacin from digestive fluid, and found that pactacin is novel digestive enzyme that is specific in teleosts.

    DOI： 10.1038/s41598-021-86565-9

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    Other Link： http://www.nature.com/articles/s41598-021-86565-9

  • Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution Reviewed

    Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Sho Isoyama, Shigeki Yasumasu, Masataka Okabe

    Scientific Reports   9 ( 1 )   2019.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    The hatcing enzyme gene (HE) encodes a protease that is indispensable for the hatching process and is conserved during vertebrate evolution. During teleostean evolution, it is known that HE experienced a drastic transfiguration of gene structure, namely, losing all of its introns. However, these facts are contradiction with each other, since intron-less genes typically lose their original promoter because of duplication via mature mRNA, called retrocopy. Here, using a comparative genomic assay, we showed that HEs have changed their genomic location several times, with the evolutionary timings of these translocations being identical to those of intron-loss. We further showed that HEs maintain the promoter sequence upstream of them after translocation. Therefore, teleostean HEs are unique genes which have changed intra- (exon-intron) and extra-genomic structure (genomic loci) several times, although their indispensability for the reproductive process of hatching implies that HE genes are translocated by retrocopy with their promoter sequence.

    DOI： 10.1038/s41598-019-38693-6

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    Other Link： https://www.nature.com/articles/s41598-019-38693-6

  • Comparison of egg envelope thickness in teleosts and its relationship to the sites of ZP protein synthesis Reviewed

    Kaori Sano, Mari Kawaguchi, Keita Katano, Kenji Tomita, Mayu Inokuchi, Tatsuki Nagasawa, Junya Hiroi, Toyoji Kaneko, Takashi Kitagawa, Takafumi Fujimoto, Katsutoshi Arai, Masaru Tanaka, Shigeki Yasumasu

    JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION   328 ( 3 )   240 - 258   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jez.b.22729

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  • Evolutionary changes in the developmental origin of hatching gland cells in basal ray-finned fishes Reviewed

    Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Kaori Sano, Masataka Okabe, Shigeki Yasumasu

    ZOOLOGICAL SCIENCE   33 ( 3 )   272 - 281   2016.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2108/zs150183

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  • Purification and molecular cloning of aspartic proteinases from the stomach of adult Japanese fire belly newts, Cynops pyrrhogaster Reviewed

    Tatsuki Nagasawa, Kaori Sano, Mari Kawaguchi, Ken-ichiro Kobayashi, Shigeki Yasumasu, Tomofumi Inokuchi

    JOURNAL OF BIOCHEMISTRY   159 ( 4 )   449 - 460   2016.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jb/mvv128

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  • An evolutionary insight into the hatching strategies of pipefish and seahorse embryos Reviewed

    Mari Kawaguchi, Yuko Nakano, Ryouka Kawahara-Miki, Mayu Inokuchi, Makiko Yorifuji, Ryohei Okubo, Tatsuki Nagasawa, Junya Hiroi, Tomohiro Kono, Toyoji Kaneko

    JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION   326 ( 2 )   125 - 135   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jez.b.22670

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  • Sturgeon hatching enzyme and the mechanism of egg envelope digestion: Insight into changes in the mechanism of egg envelope digestion during the evolution of ray-finned fish Reviewed

    Tatsuki Nagasawa, Mari Kawaguchi, Kaori Sano, Shigeki Yasumasu

    JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION   324 ( 8 )   720 - 732   2015.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jez.b.22660

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MISC

  • 孵化酵素遺伝子のイントロン消失メカニズム（寄稿） Invited

    長澤竜樹

    日本進化学会ニュース   19 ( 3 )   18 - 19   2018.11

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    Language：Japanese  

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  • アカハライモリ成体胃部域におけるアスパラギン酸プロテ アーゼの精製とクローニング Invited

    長澤竜樹, 佐野香織, 川口眞理, 小林健一郎, 安増茂樹, 井口智文

    生化学   第88巻 ( 第3号 )   429 - 429   2016

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)  

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Presentations

  • 魚類V1Rを介したフェロモン受容機構の分子基盤解明

    滝隼輔, 佐藤誠, 長澤竜樹, 二階堂雅人

    第5回日本遺伝学会春の分科会「若手フォーラム」 

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    Event date： 2025.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 脊椎動物における非感覚器に分布する化学受容体の多様性と共通性

    西浦賀乃子, 長澤竜樹, 二階堂雅人

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    Event date： 2025.2

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 魚類V1Rの機能解明を目指した分子基盤構築

    長澤竜樹, 滝隼輔, 佐藤誠, 二階堂雅人

    第10回ケモビ研究会 

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    Event date： 2025.2

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 古代魚ポリプテルスの”鼻管”に関する研究

    伊藤隆晃, 西浦賀乃子, 木村優希, 中牟田信明, 長澤竜樹, 二階堂雅人

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    Event date： 2024.9

    Language：Japanese   Presentation type：Poster presentation  

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  • volutionary genomics of transparent muscle innovation in transparent ghost catfish

    Yunfan Jia, Mitsuto Aibara, Tatsuki Nagasawa, Masaki Fujita, Yasuhiro Ando, Takehiko Ito, Masato Nikaido

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    Event date： 2024.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Molecular landscape of parallel evolution in hypertrophied-lip cichlids: An integrative comparative analysis of histology, proteomics, and transcriptomics

    Machii N., Hatashima R., Niwa T., Taguchi H., Kimirei IA, Mrosso HDJ, Aibara M., Nagasawa T., Nikaido M.

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    Event date： 2024.8

    Language：English   Presentation type：Symposium, workshop panel (public)  

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  • 脊椎動物における異所性発現する化学受容体の多様性と共通性（学生ポスター優秀賞受賞）

    西浦賀乃子, 長澤竜樹, 二階堂雅人

    第26回日本進化学会 神奈川大会 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Poster presentation  

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  • 卵保護魚類に共通した硬化卵膜の崩壊は繁殖戦略に進化的制約をもたらす

    長澤竜樹, 相原光人, 川口眞理, 安増茂樹, 二階堂雅人

    第26回日本進化学会 神奈川大会 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • ゲノム比較解析による透明ナマズの皮膚透明化機構の解明

    浦田龍, 賈云帆, 長澤竜樹, 相原光人, 伊藤武彦, 二階堂雅人

    第26回日本進化学会 神奈川大会 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Poster presentation  

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  • 魚類の全ゲノム倍化後のOMP 遺伝子発現パターンの進化的比較解析

    長澤竜樹, 藤崎花美, 二階堂雅人

    第9回ケモビ研究会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 魚類の全ゲノム重複で倍化したOMP遺伝子の進化プロセスとその多様化

    長澤竜樹, 藤崎花美, 二階堂雅人

    日本味と匂学会第57回大会  2023.9 

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    Event date： 2023.9

    Language：English   Presentation type：Poster presentation  

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  • 魚類における化学受容体の異所的な分布

    西浦賀乃子, 張子聡, 長澤竜樹, 二階堂雅人

    日本味と匂学会第57回大会  2023.9 

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  • Molecular evolution of the OMP genes after the whole genome duplication in teleost fish

    Nagasawa, T, Fujisaki, H, Nikaido, M

    XXIIIrd International Congress of Genetics  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Symposium, workshop panel (public)  

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  • 魚類孵化酵素遺伝子の遺伝子重複と新規機能遺伝子の誕生

    本田健人, 長澤竜樹, 安増茂樹, 川口眞理

    日本動物学会  2022.9 

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    Event date： 2022.9

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  • ハリネズミの針形成に関する進化発生学的起源の解明

    黒瀬成美, 田中亮輔, 小林汐織, 重谷安代, 岡部正隆, 長澤竜樹, 二階堂雅人

    日本進化学会第24回沼津大会  2022.8 

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    Event date： 2022.8

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  • 魚類の体表における化学感覚の探索

    桐ヶ窪寛, 佐久間敦丈, 長澤竜樹, 二階堂雅人

    日本進化学会第24回沼津大会  2022.8 

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  • 魚類の鰭における化学感覚受容体遺伝子の発現探索

    西浦賀乃子, 長澤竜樹, 二階堂雅人

    日本進化学会第24回沼津大会  2022.8 

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  • 魚類に見られる鼻管の適応的意義と平行進化に関する研究

    伊藤隆晃, 西浦賀乃子, 木村優希, 中牟田信明, 長澤竜樹, 二階堂雅人

    日本進化学会第24回沼津大会  2022.8 

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  • 東アフリカ産シクリッドにおける肥大化した唇の分子実態解明

    待井長敏, 畑島諒, 中村遥奈, 丹羽達也, 長澤竜樹, 二階堂雅人

    日本進化学会第24回沼津大会  2022.8 

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  • 卵保護魚類における卵膜硬化システムの収斂退化

    長澤竜樹, 相原光人, 二階堂雅人

    第6回ユニーク会  2021.9 

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  • 魚類の鰭における化学感覚受容体遺伝子の発現探索

    西浦賀乃子, 長澤竜樹, 二階堂雅人

    日本動物学会第92回大会 

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  • シクリッドの適応形質・肥大化した唇の遺伝的基盤の解明

    待井長敏, 畑島諒, 中村遥奈, 長澤竜樹, 二階堂雅人

    日本動物学会第92回大会 

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  • ハリネズミの針形成に関わる進化発生学的研究

    黒瀬成美, 田中亮輔, 小林汐織, 重谷安代, 岡部正隆, 長澤竜樹, 二階堂雅人

    日本動物学会第92回大会 

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  • 東アフリカシクリッドにおける唇肥大化の遺伝的基盤の解明（学生発表優秀賞(学部・修士課程)受賞）

    待井長敏, 畑島諒, 中村遥奈, 長澤竜樹, 二階堂雅人

    日本進化学会第23回東京大会 

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  • Elucidating genetic mechanism of cichlid hypertrophic lips, using differentially expressed gene analysis

    Machii, N, Hatashima, R, Nakamura, H, Nagasawa, T, Nikaido, M

    The 2nd AsiaEvo Conference 

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    Event date： 2021.8

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  • ゼブラフィッシュの内胚葉発現遺伝子地図に基づく肺と鰾の相同性の探索

    大嶋理香, 辰巳徳史, 姫岩翔子, 長澤竜樹, 矢野十織, 岡部正隆

    第126回 日本解剖学会総会・全国学術集会 第98回 日本生理学会大会 合同大会 

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    Event date： 2021.3

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  • 魚類の全ゲノム重複に伴うOMP遺伝子の進化多様性

    藤崎花美, 長澤竜樹, 二階堂雅人

    日本動物学会第91回大会 

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    Event date： 2020.9

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  • カワスズメ科魚類における孵化腺細胞の局在の進化

    長澤竜樹, 相原光人, 川口眞理, 二階堂雅人

    日本動物学会関東支部第72回大会  2020.3 

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  • 下位条鰭類は真骨魚類よりも両生類に類似した卵膜硬化機構をもつ

    財田里梨花, 大西洋, 長澤竜樹, 加用大地, 神田真司, 安増茂樹, 佐野香織

    日本動物学会関東支部第72回大会  2020.3 

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  • 真骨魚類レトロコピー遺伝子 -十数億年続く分子進化の制約を打ち破る- Invited

    長澤竜樹, 川口眞理, 矢野十織, 安増茂樹, 岡部正隆

    第90回日本動物学会大阪大会  2019.9 

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  • ゼブラフィッシュにおける孵化酵素の分泌機構の研究

    江藤 朱音, 川口 眞理, 長澤 竜樹, 安増 茂樹

    第90回日本動物学会大阪大会  2019.9 

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  • 魚類型孵化腺細胞と胚型赤血球の間に見られる共通性の探査

    長澤竜樹

    第71回日本動物学会関東支部大会  2019.3 

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  • Unique molecular evolution in teleost hatching enzyme genes – is this a new role of retrotransposon for evolution? - International conference

    Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Sho Isoyama, Shigeki Yasumasu, Masataka Okabe

    Unique molecular evolution in teleost hatching enzyme genes – is this a new role of retrotransposon for evolution? -  2019.7 

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  • 孵化腺細胞はどのようにしてその発生学的起源を変化させたのか

    長澤竜樹, 安増茂樹, 岡部正隆

    第41回日本分子生物学会年会  2018.11 

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  • 条鰭類の鰾の起源の検討

    姫岩翔子, 辰巳徳史, 長澤竜樹, 矢野十織, 岡部正隆

    第124回日本解剖学会総会  2019.3 

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  • ポリプテルスの鼻管における化学感覚の研究

    伊藤隆晃, 西浦賀乃子, 木村優希, 中牟田信明, 長澤竜樹, 二階堂雅人

    日本動物学会関東支部第76回大会  2024.3 

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  • 条鰭類に残存するTbx4肺エンハンサーの意義

    辰巳徳史, 庄野孝範, 隅山健太, 姫岩翔子, 長澤竜樹, 矢野十織, 岡部正隆

    第125回日本解剖学会総会・全国学術集会  2020.3 

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  • 遺伝子組換えゼブラフィッシュを用いたV1R 発現パターンの網羅的観察

    石丸敢太, 長澤竜樹, 二階堂雅人

    第4回日本遺伝学会春の分科会  2024.3 

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  • Molecular evolution of teleostean omp genes provides an inferring of the molecular evolution of Ohnologous genes

    2020.9 

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  • 条鰭類の苦味受容体遺伝子 T2R の機能的多様性

    芦宣頤, 畑島諒, 長澤竜樹, 二階堂雅人

    日本動物学会関東支部第73回大会  2021.3 

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  • イモリペプシノーゲンのcDNAクローニングと胃部域後期発生の無尾類との比較

    井口智文, 渡邊由香里, 潮田甲子朗, 加藤琢磨, 遠藤俊幸, 伊藤成慶, 鈴木雄太, 長澤竜樹, 生澤昌之, 小林健一郎

    2010.9 

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  • ニジマス孵化酵素の精製とその卵膜分解作用

    髙村早智, 長澤竜樹, 川口眞理, 安増茂樹

    第67回日本動物学会関東支部大会  2015.3 

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  • ニジマスのTGaseの遺伝子発現とそのタンパク質の局在

    佐藤ひかり, 中島大輝, 長澤竜樹, 川口眞理, 安増茂樹

    第67回日本動物学会関東支部大会  2015.3 

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  • 古代魚を用いた孵化腺細胞の発生進化学的解析

    長澤竜樹, 川口眞理, 矢野十織, 岡部正隆, 安増茂樹

    日本進化学会第16回大阪大会  2014.8 

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  • チョウザメ孵化酵素の精製と卵膜の分解機構

    長澤竜樹, 川口眞理, 安増茂樹

    日本動物学会第85回仙台大会  2014.9 

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  • アカハライモリ成体胃部域アスパラギン酸プロテアーゼの精製と発現時期の解析

    長澤竜樹, 佐野香織, 小林健一郎, 安増茂樹, 井口智文

    日本動物学会第83回大阪大会  2012.9 

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  • アカハライモリ(Cynops pyrrhogaster)成体胃部域アスパラギン酸プロテアーゼのクローニング

    長澤竜樹, 佐野香織, 川口眞理, 小林健一郎, 井口智文, 安増茂樹

    日本動物学会第84回岡山大会  2013.9 

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  • 孵化腺細胞は2種類の下位条鰭類の間で異なる胚葉から分化する

    長澤竜樹, 川口眞理, 矢野十織, 岡部正隆, 安増茂樹

    日本動物学会第86回新潟大会  2015.9 

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  • Evolutional Change of developmental origin of hatching gland cells in basal ray-finned fishes

    Tatsuki Nagasawa, Tohru Yano, Mari Kawaguchi, Masataka Okabe, Shigeki Yasumasu

    2015.9 

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  • 脊椎動物孵化腺細胞の発生進化学的解析

    長澤竜樹, 川口眞理, 矢野十織, 岡部正隆, 安増茂樹

    日本進化学会第17回東京大会  2015.8 

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  • Duplication and diversification of amphibian hatching enzyme genes

    Momo H Carlos, Tatsuki Nagasawa, Mari Kawaguchi, Shigeki Yasumasu

    2015.8 

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  • チョウザメにおける孵化腺細胞の分泌様式

    会田裕貴, 長澤竜樹, 川口眞理, 安増茂樹

    第69回日本動物学会関東支部大会  2017.3 

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  • CRISPR/Cas9 法 によるメダカ KLF17 遺伝子のノックアウト

    日野由佳子, 長澤竜樹, 川口眞理, 安増茂樹

    第69回日本動物学会関東支部大会  2017.3 

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  • The conserved enhancer of the hatching enzyme gene in ray-finned fish International conference

    Tatsuki Nagasawa, Tohru Yano, Mari Kawaguchi, Shigeki Yasumasu, Masataka Okabe

    The 22nd International Congress of Zoology  2016.11 

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  • Molecular co-evolution of a hatching enzyme and its substrate International conference

    Shigeki Yasumasu, Kaori Sano, Tathuki Nagasawa, Mari Kawaguchi

    The 22nd International Congress of Zoology  2016.11 

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  • ゼブラフィッシュFigα遺伝子の機能解析

    西野良英, 長澤竜樹, 安増茂樹, 佐野香織

    第68回日本動物学会関東支部大会  2016.3 

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  • ゼブラフィッシュ孵化酵素遺伝子のエンハンサー解析

    長澤竜樹, 矢野十織, 川口眞理, 安増茂樹, 岡部正隆

    日本進化学会第18回東京大会  2016.8 

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  • 脊椎動物における孵化腺細胞由来細胞の発生進化学的解析

    長澤竜樹, 川口眞理, 矢野十織, 岡部正隆, 安増茂樹

    第二回軟骨魚類繁殖生理研究会  2015.11 

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  • 透明魚とその近縁種を用いたDEG解析による筋肉透明化遺伝子の探索

    賈云帆, 相原光人, 長澤竜樹, 二階堂雅人

    第2回日本遺伝学会春の分科会  2022.3 

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  • ハリネズミの針形成に関わる進化発生学的研究

    黒瀬成美, 田中亮輔, 小林沙織, 重谷安代, 岡部正隆, 長澤竜樹, 二階堂雅人

    第2回日本遺伝学会春の分科会  2022.3 

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  • The intron-loss evolution by retrotranslocation in Teleost -using the hatching enzyme genes as a model-

    Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Shigeki Yasumasu, Masataka Okabe

    23rd Japanese Medaka and Zebrafish Meeting  2017.8 

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  • 免疫システムがもたらしたシクリッドの唇肥大化平行進化

    畑島諒, 待井長敏, 豊田敦, 梶谷嶺, 長澤竜樹, 伊藤武彦, 二階堂雅人

    第2回日本遺伝学会春の分科会  2022.3 

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  • 透明ナマズとその近縁種を用いた系統解析と発現変動遺伝子解析による筋肉透明化遺伝子の探索

    賈云帆, 相原光人, 長澤竜樹, 二階堂雅人

    日本動物学会関東支部第74回大会  2022.3 

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  • 孵化腺細胞はなぜ真骨魚類と両生類で発生学的起源が異なるのか？

    長澤竜樹, 川口眞理, 矢野十織, 安増茂樹, 岡部正隆

    第7回脊椎動物形態研究会(TVMM)  2017.7 

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  • マルチオミクス解析で探る「シクリッドの唇肥大化」の平行進化メカニズム

    待井長敏, 畑島諒, 中村遥奈, 丹羽達也, 田口 英樹, 長澤竜樹, 二階堂雅人

    日本動物学会関東支部第74回大会  2022.3 

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  • 真骨魚類の進化過程において孵化酵素遺伝子はintronを失いながら、頻繁にretrotranslocationを起こした

    長澤竜樹, 川口眞理, 矢野十織, 安増茂樹, 岡部正隆

    日本進化学会第19回京都大会  2017.8 

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  • Inferring of the effect of klf17 to the development of teleost-type hatching gland cells

    Tatsuki Nagasawa, Shigeki Yasumasu, Masataka Okabe

    24th Japanese Medaka and Zebrafish Meeting  2018.8 

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  • 真骨魚類孵化酵素遺伝子のイントロン消失メカニズム -ゲノム構造の進化的制約から解放された遺伝子の分子進化- Invited

    長澤竜樹, 川口眞理, 矢野十織, 磯山翔, 安増茂樹, 岡部正隆

    日本動物学会第89回札幌大会  2018.9 

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  • 卵膜遺伝子とその硬化機構の進化~両生類・下位条鰭類・真骨魚類~

    佐野香織, 大西洋, 長澤竜樹

    第4回 ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会  2018.8 

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  • 孵化酵素遺伝子のイントロン消失メカニズム：分子進化におけるレトロコピーの新たな役割の考察

    長澤竜樹, 川口眞理, 矢野十織, 磯山翔, 安増茂樹, 岡部正隆

    日本進化学会第20回東京大会  2018.8 

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  • Co-evolution of fish hatching enzyme and its substrate. International conference

    Shigeki Yasumasu, Kaori Sano, Tatsuki Nagasawa, Mari Kawaguchi

    Society for Integrative and Comparative Biology  2018.1 

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  • チョウザメの含気器官の組織学的分子生物学的解析と鰾の起源に関する考察

    姫岩翔子, 辰巳徳史, 長澤竜樹, 矢野十織, 岡部正隆

    第123回・日本解剖学会総会・全国学術集会  2018.3 

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  • 真骨魚類の進化過程において孵化酵素遺伝子が頻繁に経験したretrotranslocationとintron-lossの関係

    長澤竜樹, 川口眞理, 矢野十織, 安増茂樹, 岡部正隆

    日本動物学会第88回富山大会  2017.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Teleostean hatching enzyme genes underwent retrotranslocation along with the promoter

    2017.12 

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  • Ectopic expression of chemoreceptor genes in fish

    Nishiura, K, Zhang, Z, Nagasawa, T, Nikaido, M

    2023.9 

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  • Genetic mechanisms of lip hypertrophy in East African cichlids

    Machii, N, Hatashima R, Aibara M, Nagasawa T, Nikaido M

    International Symposium on Evolutionary Genomics and Bioinformatics 2023  2023.6 

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  • 魚類に見られる鼻管の機能解明

    伊藤隆晃, 西浦賀乃子, 木村優希, 中牟田信明, 長澤竜樹, 二階堂雅人

    第11回Tokyo Vertebrate Morphology Meeting  2023.7 

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  • 魚類の鼻管に関する研究

    伊藤隆晃, 西浦賀乃子, 木村優希, 中牟田信明, 長澤竜樹, 二階堂雅人

    日本動物学会関東支部会第24回大会  2023.3 

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  • 脊椎動物における母性発現の進化に関する研究

    伊藤隆晃, 長澤竜樹, 二階堂雅人

    第3回日本遺伝学会春の分科会  2023.3 

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  • 魚類におけるOMP遺伝子の分子進化

    長澤竜樹, 藤崎花美, 二階堂雅人

    第8回 ケモビ研究会  2023.3 

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  • 真骨魚類に至る卵膜遺伝子の進化

    佐野 香織, 大西 洋, 長澤 竜樹, 安増 茂樹

    日本動物学会第89回札幌大会  2018.9 

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  • 透明ナマズとその近縁種を用いた発現変動遺伝子解析による筋肉透明化遺伝子の探索

    賈云帆, 相原光人, 長澤竜樹, 伊藤武彦, 二階堂雅人

    日本動物学会関東支部会第24回大会  2023.3 

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  • 孵化腺細胞の細胞学的差異は発生学的起源の変化とは独立に生じた

    会田裕貴, 長澤竜樹, 川口眞理, 安増茂樹

    日本動物学会第89回札幌大会  2018.9 

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  • Differentiation mechanism of fish-type hatching cells approaching from transcription factor

    2018.9 

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Awards

  • 笹川科学研究奨励賞

    2021.6   日本科学協会  

    長澤竜樹

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  • 大隅良典基礎研究支援

    2020.1  

    長澤竜樹

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  • 若手口頭発表最優秀賞

    2018.8   日本進化学会   孵化酵素遺伝子のイントロン消失メカニズム：分子進化におけるレトロコピーの新たな役割の考察

    長澤竜樹, 川口眞理, 矢野十織, 磯山翔, 安増茂樹, 岡部正隆

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  • ポスター発表優秀賞

    2025.8   日本進化学会   透明ナマズとその近縁種のゲノム比較による 体組織透明化メカニズムの解明

    賈云帆, 浦田龍, 相原光人, 長澤竜樹, 伊藤武彦, 藤田雅紀, 安藤靖浩, 二階堂雅人

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  • 第26回日本進化学会 学生ポスター発表 優秀賞受賞

    2024.8   日本進化学会   脊椎動物における異所性発現する化学受容体の多様性と共通性

    西浦賀乃子, 長澤竜樹, 二階堂雅人

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  • 日本進化学会第23回東京大会 学生発表優秀賞(学部・修士課程)

    2021.8   日本進化学会   東アフリカシクリッドにおける唇肥大化の遺伝的基盤の解明

    待井長敏, 畑島諒, 中村遥奈, 長澤竜樹, 二階堂雅人

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  • 第124回 日本解剖学会総会・全国学術集会 学生セッション優秀発表賞

    2019.3   日本解剖学会   条鰭類の鰾の起源の検討

    姫岩翔子、辰巳徳史、長澤竜樹、矢野十織、岡部正隆

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Research Projects

  • 2025 SMBE @Beijingでの発表支援

    2025.7

    日本科学協会  海外発表促進助成 

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    Authorship：Principal investigator 

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  • 東アフリカ産シクリッドの適応放散と平行進化をもたらした大規模な祖先多型の起源

    Grant number：24KK0141  2024.9 - 2029.3

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(海外連携研究)

    二階堂 雅人 (代表), 中村遥奈, 高橋鉄美, 長澤竜樹

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    Authorship：Coinvestigator(s) 

    Grant amount：\20930000 （ Direct Cost: \16100000 、 Indirect Cost：\4830000 ）

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  • 近縁ナマズ２種のゲノム比較に基づく体組織の高度な透明化に関わる遺伝子基盤

    Grant number：24K21986  2024.6 - 2027.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    二階堂 雅人 (代表), 長澤竜樹, 渡邊正勝, 伊藤武彦

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    Authorship：Coinvestigator(s) 

    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

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  • 脊椎動物が共有する鋤鼻受容体ancV1Rを介したフェロモン受容機構とその適応的意義

    Grant number：24K02074  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    二階堂雅人(代表)、長澤竜樹、村田健、廣田順二

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    Authorship：Coinvestigator(s) 

    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • 進化的に高度に保存された魚類 V1R陽性細胞における分子基盤構築と哺乳類との比較研究

    2024.4 - 2025.2

    日本科学協会  笹川科学研究助成 

    長澤竜樹

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    Authorship：Principal investigator 

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  • ゲノム倍化がもたらす分子進化の影響を数億年スケールで追跡する

    Grant number：23K14249  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    長澤 竜樹

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 複雑な嗅覚処理に寄与する保存的な遺伝子の転写制御メカニズムの解明

    2023.4 - 2024.2

    日本科学協会  笹川科学研究助成 

    長澤竜樹

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  • 卵保護をする魚類における孵化酵素と卵膜の平行共進化の研究

    2021.4 - 2022.3

    公益財団法人藤原ナチュラルヒストリー振興財団  第29回学術研究助成 

    長澤竜樹

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    Authorship：Principal investigator 

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  • 東アフリカ産シクリッドの適応進化と平行進化の分子メカニズム解明

    2020.11 - 2024.3

    日本学術振興会  国際共同研究加速基金（国際共同研究強化Ｂ）  国際共同研究加速基金（国際共同研究強化Ｂ）

    二階堂雅人(代表)、高橋鉄美、長澤竜樹

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  • 孵化腺細胞の進化発生学的研究による新しい進化モデルの提唱-胚葉を越えた機能転移-

    2020.4 - 2023.3

    日本学術振興会  学術研究助成基金助成金 若手研究 

    長澤竜樹

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  • 孵化腺細胞欠損変異体の遺伝子発現解析：胚葉を越えた機能転移はどのようにして起こったか

    2020.4 - 2021.2

    日本科学協会  笹川科学研究助成 

    長澤竜樹

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  • 細胞レベルで起こった収斂進化のメカニズムの解明－孵化腺細胞をモデルとして－

    2017.4 - 2020.3

    日本学術振興会  日本学術振興会特別研究員PD 

    長澤竜樹

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  • Infrastructure development for experimental animalization of ancient fish Polypterus as an ancestor model of tetrapods

    Grant number：15K08145  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Okabe Masataka, TATSUMI Norifumi, NAGASAWA Tatsuki

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Polypterus senegalus (bichir) is a member of the Actinopterygii; the larva has external gill and the adult uses lung for respiration. To establish the bichir bioresource in Japan, we have developed breeding systems and transgenic/gene-editing methods, for a stable supply of bichir embryos and larvae. We have investigated mechanisms of development of respiratory organs (external gill and lung) and the morphology of locomotor organs (appendages).

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Teaching Experience

  • 最先端生命科学研究特論

    2022.10 Institution：Chiba Institute of Technology

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  • Fundamental Life Science

    2020.12 Institution：Tokyo Institute of Technology

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  • LST Seminar 4

    2020.1 Institution：Tokyo Institute of Technology

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  • Fundamental Life Science Laboratory

    2019.10 Institution：Tokyo Institute of Technology

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  • 理科総合B

    2011.4 - 2012.3 Institution：栃木県立小山南高校

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Media Coverage

  • 東京科学大学など、遺伝子と繁殖戦略の関係解明 Newspaper, magazine

    ㈱水産経済新聞社  日刊水産経済新聞  https://www.suikei.co.jp/archives/53914  2025.6

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