Updated on 2026/03/24

写真a

 
HIRATA Keisuke
 
Organization
School of Science Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree

  • 博士(理学) ( 東京大学 )

Research Interests

  • Molecular spectroscopy, Cluster

  • Infrared spectroscopy

  • Molecular spectroscopy

  • (Bio)molecular recognition

  • Metal cluster

  • Ion trap

  • プロトン移動

  • Electrospray ionization (ESI)

Research Areas

  • Nanotechnology/Materials / Fundamental physical chemistry

  • Nanotechnology/Materials / Nanometer-scale chemistry

Education

  • 東京大学大学院   理学系研究科   化学専攻 博士課程

    2016.4 - 2019.3

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  • 東京大学大学院   理学系研究科   化学専攻 修士課程

    2014.4 - 2016.3

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  • The University of Tokyo   Faculty of Science   Department of Chemistry

    2012.4 - 2014.3

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  • The University of Tokyo

    2010.3 - 2012.4

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Research History

  • Institute of Science Tokyo   Department of Chemistry, School of Science   Assistant Professor

    2024.10

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  • Tokyo Institute of Technology   Department of Chemistry, Graduate School of Science   Assistant Professor

    2021.4 - 2024.9

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  • Tokyo Institute of Technology   Institute of Innovative Research   Assistant Professor

    2019.4 - 2021.3

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    Country:Japan

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Professional Memberships

Committee Memberships

  •   8th Asian Spectroscopy Conference 2023 Local organizing committee  

    2020.1 - 2023.8   

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    Committee type:Academic society

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Papers

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Books

  • Physical Chemistry of Cold Gas-Phase Functional Molecules and Clusters

    Kiichirou Koyasu, Keisuke Hirata, Tatsuya Tsukuda( Role: ContributorCharacterization of Chemically Modified Gold/Silver Superatoms in the Gas Phase)

    Springer  2019 

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MISC

  • New structural analysis of biomolecules by native mass spectrometry Invited

    Keisuke Hirata

    2025.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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  • Hydration Effects on Molecular Functions Revealed by Cryogenic Ion Spectroscopy Invited Reviewed

    Keisuke Hirata

    Molecular Science   19 ( 1 )   A0138 - A0138   2025.9

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Japan Society for Molecular Science  

    DOI: 10.3175/molsci.19.a0138

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  • 生体における精巧な分子認識の起源を水和の観点から解き明かす Invited

    平田圭祐

    化学と工業   77 ( 7 )   496 - 497   2024.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

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  • 注目の論文:微小液滴中で加速する化学反応ー液滴中でのベンゾイミダゾール合成法の開発ー Invited

    平田圭祐

    月刊 化学   ( 76 )   64 - 65   2021.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Presentations

  • Probing the principal interaction of nicotine with the tryptophan residue in the nicotinic acetylcholine receptor by cryogenic ion spectroscopy International conference

    Keisuke Hirata

    3rd International Symposium of UCSB-JSPS Core-to-Core Program on “Elucidation of solvation effects on molecular recognition”  2025.9 

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    Event date: 2025.9

    Language:English   Presentation type:Oral presentation (general)  

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  • Elucidating hydration effects on molecular recognition by cryogenic ion spectroscopy Invited

    Keisuke Hirata

    The 19th Annual Meeting of Japan Society for Molecular Science  2025.9 

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    Event date: 2025.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Molecular-level approach to glycan recognition in immune systems: Cryogenic ion spectroscopy of a partial peptide in mannose-binding proteins with monosaccharide

    Keisuke Hirata, Taisei Takahashi, Shun-ichi Ishiuchi

    The 105th CSJ Annual Meeting (2025)  2025.3 

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    Event date: 2025.3

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • アセチルコリン受容体部分ペプチドーニコチン複合体の冷却イオントラップ赤外分光 International coauthorship

    大倉 由楓, Garrett Santis, Madisen Hallsten, 平田 圭祐, Sotiris Xantheas, 藤井 正明, 石内 俊一

    第18回分子科学討論会  2024.9 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Probing proton transfer mechanisms in hydrated clusters by cryogenic double ion trap spectroscopy Invited International conference

    Keisuke Hirata

    1st International Symposium of JSPS Core-to-Core Program on “Elucidation of solvation effects on molecular recognition”  2024.7 

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    Event date: 2024.7

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • Hydration effect on ion recognition of valinomycin revealed by cryogenic ion spectroscopy International conference

    Keisuke Hirata

    13th Conference on Isolated Biomolecules and Biomolecular Interactions (IBBI 2024)  2024.4 

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    Event date: 2024.4

    Language:English   Presentation type:Oral presentation (general)  

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  • Cooperative hydration effect on ion recognition probed by cryogenic ion spectroscopy Invited

    Keisuke Hirata

    The 104th CSJ Annual Meeting (2024)  2024.3 

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    Event date: 2024.3

    Language:Japanese  

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  • Revealing ion recognition mechanisms of naturally occurring ionophores by cryogenic ion trap infrared spectroscopy Invited

    Keisuke Hirata

    The 104th CSJ Annual Meeting (2024)  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Cryogenic ion trap infrared spectroscopy of hydrated clusters of protonated p-aminobenzoic acid: Revealing the intramolecular proton transfer

    Keisuke Hirata, Kyota Akasaka, Otto Dopfer, Sotaro Ohara, Yamada Miyu, Haruki Ishikawa, Masaaki Fujii, Shun-ichi Ishiuchi

    The 17th Annual Meeting of Japan Society for Molecular Science  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

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  • Probing hydration-induced proton transfer of protonated p-aminobenzoic acid by cryogenic ion trap infrared spectroscopy Invited

    Keisuke Hirata

    8th Asian Spectroscopy Conference 2023  2023.9 

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    Event date: 2023.9

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • Bottom-up approach to the ion recognition of K+ channels by cryogenic double ion trap infrared spectroscopy

    Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, Masaaki Fujii

    The 103rd CSJ Annual Meeting (2023)  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Cold ion trap infrared spectroscopy of the complexes of the alkali metal ions and a partial peptide of K+ channels: Temperature effect on K+ selectivity

    Keisuke Hirata, Yukina Suzuki, James M. Lisy, Shun-ichi Ishiuchi, Masaaki Fujii

    The 16th Annual Meeting of Japan Society for Molecular Science  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Probing protonation site switching in hydrated clusters by cryogenic ion spectroscopy: The case of p-amiinobenzoic acid derivatives International conference

    Keisuke Hirata

    2nd International Symposium of JSPS Core-to-Core Program on “Molecular Recognition Mechanism between Flexible Molecules”  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

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  • Vibrational spectroscopy of hydrated clusters of valinomycin-metal complexes: Watching single water hydration

    Keisuke Hirata

    Pacifichem 2021  2021.12 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

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  • Cryogenic ion trap infrared spectroscopy of hydrated protonated benzocaine -Intramolecular proton transfer by hydration-

    Keisuke Hirata, Fuad Haddad, Otto Dopfer, Shun-ichi Ishiuchi, Masaaki Fujii

    The 15th Annual Meeting of Japan Society for Molecular Science  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Poster presentation  

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  • Molecular-level understanding of intramolecular proton transfer by cryogenic ion trap infrared spectroscopy Invited

    Keisuke Hirata

    15th Laser Spectroscopy Symposium for Young Researchers  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Hydration Effect on K+ Selectivity of Valinomycin Revealed by Cryogenic Ion Spectroscopy

    Keisuke Hirata

    Gordon Conference Molecular and Ionic Clusters  2020.1 

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    Event date: 2020.1

    Language:English   Presentation type:Poster presentation  

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  • Isomerization of [PdAu8(PPh3)8]2+ in the gas phase

    Keisuke Hirata, Satoru Muramatsu, Papri Chakraborty, Abhijit Nag, Shinjiro Takano, Kiichirou Koyasu, Tatsuya Tsukuda, Thalappil Pradeep

    The 98th CSJ Annual Meeting (2018)  2018.3 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

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  • Direct Observation of Superatomic Orbitals of Ligand-Protected Metal Clusters by Anion Photoelectron Spectroscopy

    Keisuke Hirata, Keishiro Yamashita, Shinjiro Takano, Keijiro Ohshimo, Toshiyuki Azuma, Ryuzo Nakanishi, Takashi Nagata, Seiji Yamazoe, Kiichirou Koyasu, Tatsuya Tsukuda

    The 11th Annual Meeting of Japan Society for Molecular Science  2017.9 

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    Event date: 2017.9

    Language:Japanese  

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  • Anion Photoelectron Spectroscopy of Free Thiolate-Protected Metal Clusters

    Keisuke Hirata, Keishiro Yamashita, Satoru Muramatsu, Shinjiro Takano, Seiji Yamazoe, Kiichirou Koyasu, Tatsuya Tsukuda

    International Symposium on Monolayer-Protected Clusters  2017.8 

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

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  • Anion Photoelectron Spectroscopy of Thiolate-Protected Au25 Clusters in Gas Phase

    Keisuke Hirata, Satoru Muramatsu, Keishiro Yamashita, Shinjiro Takano, Seiji Yamazoe, Kiichirou Koyasu, Tatsuya Tsukuda

    The 97th CSJ Annual Meeting (2017)  2017.3 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

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  • Surface-Induced Dissociation Mass Spectrometry of Thiolate-Protected Metal Clusters

    Keisuke Hirata, Shinjiro Takano, Sojiro Emori, Hirokazu Kitazawa, Seiji Yamazoe, Kiichirou Koyasu, Tatsuya Tsukuda

    The 10th Annual Meeting of Japan Society for Molecular Science  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Surface-Induced Dissociation of Thiolate-Protected Metal Clusters

    Keisuke Hirata, Shinjiro Takano, Sojiro Emori, Seiji Yamazoe, Kiichirou Koyasu, Tatsuya Tsukuda

    Cluster Surface Interaction Workshop 2016  2016.5 

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    Event date: 2016.5

    Language:English   Presentation type:Poster presentation  

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Awards

  • 19th PCCP Prize

    2025.3   Chemical Society of Japan   Hydration-triggered molecular functions revealed by cryogenic ion spectroscopy

    Keisuke Hirata

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    Award type:Award from Japanese society, conference, symposium, etc. 

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  • 第17回分子科学会奨励賞

    2024.9   分子科学会   冷却イオン分光法による分子認識における水和効果の解明

    平田圭祐

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    Award type:Award from Japanese society, conference, symposium, etc. 

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  • CSJ Young Scholar Lecture 2024

    2024.3   Chemical Society of Japan   Revealing ion recognition mechanisms of naturally occurring ionophores by cryogenic ion trap infrared spectroscopy

    Keisuke Hirata

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    Award type:Award from Japanese society, conference, symposium, etc. 

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  • Young Researcher's Award

    2023.12   Tokyo Institute of Technology   Revealing ion recognition mechanisms of flexible molecules by cryogenic ion trap infrared spectroscopy

    Keisuke Hirata

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Research Projects

  • 高速キラル分離イオントラップの開発と非共有結合性キラリティへの展開

    2026.1 - 2027.3

    公益財団法人精密測定技術振興財団  精密測定技術振興のための調査・研究事業 

    平田圭祐

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  • 水を不斉源とするキラル化学のための革新的水クラスター生成技術の開拓

    2025.10 - 2026.9

    公益財団法人クリタ水・環境科学振興財団  クリタ水・環境科学振興財団 研究助成萌芽的研究b 

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    Authorship:Principal investigator 

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  • トリプルイオントラップ法によるクラスター内プロトン移動反応の学理構築

    Grant number:25K01726  2025.4 - 2028.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    平田圭祐

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    Authorship:Principal investigator 

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  • 先端分子分光学の開拓によるクラウンエーテルのイオン選択性の原理の解明

    2023.6 - 2024.6

    東京工業大学  あすなろ研究奨励金 

    平田 圭祐

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  • 糖鎖認識機構の解明に向けた冷却イオントラップ分光技術の開発

    2023.1 - 2024.3

    公益財団法人精密測定技術振興財団  精密測定技術振興のための調査・研究事業 

    平田 圭祐

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  • Revealing molecular-level mechanisms of intramolecular proton transfer by cryogenic ion trap spectroscopy

    Grant number:21K14585  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 冷却イオン分光によるイオン選択性分子に対する微視的水和効果の解明

    Grant number:21H04674  2021.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(A)

    石内 俊一, 平田 圭祐

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    Grant amount:\42380000 ( Direct Cost: \32600000 、 Indirect Cost:\9780000 )

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  • Molecular recognition mechanism of adrenaline receptors studied by ESI- ion trap spectroscopy

    Grant number:20H00372  2020.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Grant amount:\44720000 ( Direct Cost: \34400000 、 Indirect Cost:\10320000 )

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  • 冷却イオントラップ分光による天然変性タンパク質複合体へのボトムアップアプローチ

    Grant number:20K20446  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(開拓)

    藤井 正明, 石内 俊一, 平田 圭祐, 宮崎 充彦

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    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\6000000 )

    1)YEMPS-ドーパおよびノルアドレナリン複合体のの冷却イオントラップ赤外分光
    天然変性タンパク質であるα-シヌクレインのドーパミン結合部位にはドーパミン誘導体であるドーパやノルアドレナリンも結合することが分かっている。そこで,YEMPS配列の部分ペプチドAc-YEMPS-NHMe(以降YEMPS)とプロトン付加ドーパおよびプロトン付加ノルアドレナリンの複合体をエレクトロスプレーで気相中に取り出し,冷却イオントラップ中の極低温下で赤外スペクトルを測定した。ドーパミン複合体の場合と同様に,プロトン化アミノ基がYEMPSと優先的に結合するのを阻害するために,18C6クラウンエーテルでプロトン化アミノ基を包接保護した。その結果,これら2つの複合体でも,YEMPSとカテコールOH基が結合した構造を形成させることができた。YEMPSの2 次構造を明らかにするために,ペプチド結合のC=O伸縮振動(amide-I)を測定したところ,1650 cm-1にバンドが観測され,α-ヘリックス構造が形成されていることが確認された。従って,ドーパミンと同様に,ドーパやノルアドレナリンも複合体形成によりYEMPSにヘリックス構造を誘起することが分かった。
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    2)異性体分離したスペクトル測定法の検討
    クラウンエーテルを付加した複合体ではUVスペクトルの測定が困難なため,UVスペクトルを用いた異性体分離ができない。そこで,IRスペクトルのみを用いて異性体分離したスペクトルを測定する方法であるIR-IR dip分光法を用いる必要があるが,これを実現するためには,1本目のIR照射と2本目のIR照射の間で質量分析する必要があり,現有装置では困難である。そのため,冷却イオントラップの後の線形飛行時間方質量分析器を2段の質量分析器に改造する必要があり,最適な方法をイオン軌道シミュレーションを用いて確立した。

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  • バリノマイシンのカリウムイオン選択性の水和効果の解明

    2019.8 - 2022.3

    日本学術振興会  科学研究費助成事業 研究活動スタート支援 

    平田 圭祐

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    Authorship:Principal investigator  Grant type:Competitive

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Social Activities

  • 第219回実験化学講座(突然色がつく反応の謎に迫る-時計反応の化学-)

    Role(s): Lecturer, Demonstrator

    国立科学博物館、日本化学会関東支部、東京都理化教育研究会  2025.2

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    Audience: General

    Type:Visiting lecture

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