Organization
School of Engineering Associate Professor
Title
Associate Professor
External link
Toma Mana
Research Interests
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biosensor
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Surface plasmons
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colloidal lithography
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3D nanostructures
Research Areas
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Measurement engineering / Biosensor
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Nanotechnology/Materials / Optical engineering and photon science / Plasmonics
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Nanotechnology/Materials / Nanomaterials
Research History
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Institute of Science Tokyo Associate Professor
2024.10
Country：Japan
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Tokyo Institute of Technology School of Engineering Associate Professor
2023.4 - 2024.9
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Tokyo Institute of Technology School of Engineering Assistant Professor
2019.4 - 2023.3
Country：Japan
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Kwansei Gakuin University School of Science and Technology Assistant Professor
2015.4 - 2019.3
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ユーリッヒ総合研究機構 博士研究員
2013.12 - 2014.10
Country：Germany
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University of California, Irvine
2012.11 - 2013.11
Country：United States
Committee Memberships
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応用物理学会 機関誌編集委員
2024.4
Committee type：Academic society
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応用物理学会 フォトニクス分科会 幹事
2021.4 - 2023.3
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応用物理学会 有機分子・バイオエレクトロニクス分科会 幹事
2019.4 - 2021.3
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応用物理学会 プログラム編集委員（中分類12.7）
2018.11 - 2022.10
Papers
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Experimental demonstration of optical cloaking of a free-standing Ag nanowire
Shinichi Ikari, Mana Toma, Masayuki Shimojo, Kotaro Kajikawa
Optics Letters 2026.4
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Imaging hole transport at catalyst-coated MIS photoanodes for water splitting under high-intensity illumination
Kanokwan Klahan, Bertrand Goudeau, Patrick Garrigue, Véronique Lapeyre, Lionel Santinacci, Mana Toma, Pichaya Pattanasattayavong, Gabriel Loget
Chemical Science 2026
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Spectrometer-free plasmonic biosensor for rapid detection of egg allergen ovomucoid Reviewed
Daiki Hirabayashi, Hiromu Miki, Mana Toma
Analytica Chimica Acta 2025.12
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Metal Nanopillar Arrays Fabricated with Moth-Eye Films for Adjustable Plasmonic Colors and Colorimetric Plasmonic Sensing Invited Reviewed
Yosuke Sugimoto, Kotaro Kajikawa, Dirk Mayer, Andreas Offenhäusser, Mana Toma
ACS Applied Nano Materials 2024.12
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Ultrabroadband invisibility cloaking design of a concentric multilayered cylindrical metamaterial Reviewed
Tomoya Momose, Mana Toma, Kotaro Kajikawa
Journal of the Optical Society of America B 2024.8
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Mana Toma, Shinnosuke Namihara, Kotaro Kajikawa
Analytical Methods 15 ( 22 ) 2755 - 2760 2023.5
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Weatherable, solvent-soluble, paintable and transparent fluoropolymers for daytime radiative cooling Reviewed
Hoang Thi Thanh Tam, Mana Toma, Takayuki Okamoto, Mio Hidaka, Kensuke Fujii, Yasuhiro Kuwana, Kotaro Kajikawa
International Journal of Thermal Sciences 184 107959 - 107959 2023.2
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Sensitive Label‐Free Immunoassay by Colorimetric Plasmonic Biosensors Using Silver Nanodome Arrays Reviewed
Mana Toma, Yuji Itakura, Shinnosuke Namihara, Kotaro Kajikawa
Advanced Engineering Materials 25 ( 3 ) 2022.10
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Investigation of polyesters as daytime radiative cooling materials Reviewed
Hoang Thi Thanh Tam, Mana Toma, Kotaro Kajikawa
MOLECULAR CRYSTALS AND LIQUID CRYSTALS 2022.2
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Tuning plasmonic colors of Ag nanodomes by the arrangement of polystyrene beads template Reviewed
Yosuke Sugimoto, Kotaro Kajikawa, Mana Toma
MOLECULAR CRYSTALS AND LIQUID CRYSTALS 729 ( 1 ) 61 - 67 2021.11
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Effect of Arrangement of Ag Nanodomes on Performance of Plasmonic Sensor Invited Reviewed
Mana Toma, Yuji Itakura, Kotaro Kajikawa
SENSORS AND MATERIALS 33 ( 1 ) 201 - 209 2021
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A visible and near-infrared broadband light absorber of cone-shaped metallic cavities Reviewed
Yuki Nakamura, Mana Toma, Kotaro Kajikawa
APPLIED PHYSICS EXPRESS 13 ( 6 ) 2020.6
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Design by neural network of concentric multilayered cylindrical metamaterials Reviewed
Naoto Akashi, Mana Toma, Kotaro Kajikawa
APPLIED PHYSICS EXPRESS 13 ( 4 ) 2020.4
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Size effect of metal nanodome arrays on performance of plasmonic biosensor Reviewed
Mana Toma, Ryo Tanaka, Keiko Tawa
JAPANESE JOURNAL OF APPLIED PHYSICS 59 2020.3
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Plasmonic coloration of silver nanodome arrays for a smartphone-based plasmonic biosensor Reviewed
Mana Toma, Keiko Tawa
NANOSCALE ADVANCES 1 ( 9 ) 3699 - 3708 2019.9
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Design of Metamaterials using Neural Networks
Naoto Akashi, Mana Toma, Kotaro Kajikawa
PLASMONICS IV 11194 2019
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Study on the Mechanism of Diarylethene Crystal Growth by in Situ Microscopy and the Crystal Growth Controlled by an Aluminum Plasmonic Chip Reviewed
Taiga Kadoyama, Ryo Nishimura, Mana Toma, Kingo Uchida, Keiko Tawa
Langmuir 34 ( 14 ) 4217 - 4223 2018.4
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In situ optical and spectroscopic imaging of photochromic cyclization and crystallization of a diarylethene film with optical microscopy Reviewed
Keiko Tawa, Taiga Kadoyama, Ryo Nishimura, Mana Toma, Kingo Uchida
Journal of Photochemistry and Photobiology A: Chemistry 356 397 - 402 2018.4
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Thickness dependence of polydopamine thin films on detection sensitivity of surface plasmon-enhanced fluorescence biosensors Reviewed
Mana Toma, Keiko Tawa
Japanese Journal of Applied Physics 57 ( 3 ) 2018.3
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Rapid and sensitive detection of neuron specific enolase with a polydopamine coated plasmonic chip utilizing a rear-side coupling method Reviewed
M. Toma, S. Izumi, K. Tawa
Analyst 143 ( 4 ) 858 - 864 2018.2
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Dual-color fluorescence imaging of EpCAM and EGFR in breast cancer cells with a bull’s eye-type plasmonic chip Reviewed
Shota Izumi, Shohei Yamamura, Naoko Hayashi, Mana Toma, Keiko Tawa
Sensors (Switzerland) 17 ( 12 ) 2017.12
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Flexible Gold Nanocone Array Surfaces as a Tool for Regulating Neuronal Behavior Reviewed
Mana Toma, Andreea Belu, Dirk Mayer, Andreas Offenhaeusser
SMALL 13 ( 24 ) 2017.6
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Enhanced fluorescence microscopy with the Bull's eye-plasmonic chip Reviewed
Keiko Tawa, Shota Izumi, Chisato Sasakawa, Chie Hosokawa, Mana Toma
OPTICS EXPRESS 25 ( 9 ) 10622 - 10631 2017.5
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Interleukin-6 Detection with a Plasmonic Chip Reviewed
Tawa Keiko, Sumiya Masashi, Toma Mana, Sasakawa Chisato, Sujino Takuma, Miyaki Tatsuki, Nakazawa Hikaru, Umetsu Mitsuo
JOURNAL OF MOLECULAR AND ENGINEERING MATERIALS 4 ( 3 ) 2016.9
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Polydopamine Thin Films as Protein Linker Layer for Sensitive Detection of Interleukin-6 by Surface Plasmon Enhanced Fluorescence Spectroscopy Reviewed
Mana Toma, Keiko Tawa
ACS APPLIED MATERIALS & INTERFACES 8 ( 34 ) 22032 - 22038 2016.8
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Gold Nanoring Arrays for Near Infrared Plasmonic Biosensing Reviewed
Mana Toma, Kyunghee Cho, Jennifer B. Wood, Robert M. Corn
PLASMONICS 9 ( 4 ) 765 - 772 2014.8
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Plasmon-Enhanced Fluorescence Biosensors: a Review
Martin Bauch, Koji Toma, Mana Toma, Qingwen Zhang, Jakub Dostalek
PLASMONICS 9 ( 4 ) 781 - 799 2014.8
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Flexible Teflon Nanocone Array Surfaces with Tunable Superhydrophobicity for Self-Cleaning and Aqueous Droplet Patterning
Mana Toma, Gabriel Loget, Robert M. Corn
ACS APPLIED MATERIALS & INTERFACES 6 ( 14 ) 11110 - 11117 2014.7
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Fabrication of Broadband Antireflective Plasmonic Gold Nanocone Arrays on Flexible Polymer Films Reviewed
Mana Toma, Gabriel Loget, Robert M. Corn
NANO LETTERS 13 ( 12 ) 6164 - 6169 2013.12
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High fidelity surface attachment chemistries and surface enzymatic reactions of nucleic acid monolayers on microarrays, nanoparticles, and nanorings for multiplexed ultrasensitive biosensing with near infrared SPR imaging and FT-NIR LSPR spectroscopy Reviewed
Corn Robert M, Wood Jennifer B, Halpern Aaron R, Cho Mike, Toma Mana, Loget Gabriel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246 2013.9
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Tuning Colors of Silver Nanoparticle Sheets by Multilayered Crystalline Structures on Metal Substrates Reviewed
Koichi Okamoto, Brian Lin, Keisuke Imazu, Akihito Yoshida, Koji Toma, Mana Toma, Kaoru Tamada
PLASMONICS 8 ( 2 ) 581 - 590 2013.6
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Active Control of SPR by Thermoresponsive Hydrogels for Biosensor Applications Reviewed
Mana Toma, Ulrich Jonas, Anca Mateescu, Wolfgang Knoll, Jakub Dostalek
JOURNAL OF PHYSICAL CHEMISTRY C 117 ( 22 ) 11705 - 11712 2013.6
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Bloch surface wave-enhanced fluorescence biosensor Reviewed
Koji Toma, Emiliano Descrovi, Mana Toma, Mirko Ballarini, Pietro Mandracci, Fabrizio Giorgis, Anca Mateescu, Ulrich Jonas, Wolfgang Knoll, Jakub Dostalek
BIOSENSORS & BIOELECTRONICS 43 108 - 114 2013.5
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Bragg-Scattered Surface Plasmon Microscopy: Theoretical Study Reviewed
Mana Toma, Wolfgang Knoll, Jakub Dostalek
PLASMONICS 7 ( 2 ) 293 - 299 2012.6
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Surface plasmon-coupled emission on plasmonic Bragg gratings Reviewed
Mana Toma, Koji Toma, Pavel Adam, Jiri Homola, Wolfgang Knoll, Jakub Dostalek
OPTICS EXPRESS 20 ( 13 ) 14042 - 14053 2012.6
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Fabrication and Application of Plasmonic Silver Nanosheet
Mana Toma
REVIEWS IN PLASMONICS 2012
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Collective plasmon modes excited on a silver nanoparticle 2D crystalline sheet Reviewed International journal
Mana Toma, Koji Toma, Kanae Michioka, Yasuhiro Ikezoe, Daiki Obara, Koichi Okamoto, Kaoru Tamada
Physical Chemistry Chemical Physics 13 ( 16 ) 7459 - 7466 2011.4
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Collective plasmon modes excited on a silver nanoparticle 2D crystalline sheet Reviewed
Mana Toma, Koji Toma, Kanae Michioka, Yasuhiro Ikezoe, Daiki Obara, Koichi Okamotod, Kaoru Tamadaw
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 13 ( 16 ) 7459 - 7466 2011
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Nanoscale coupling of photons to vibrational excitation of Ag nanoparticle 2D array studied by scanning tunneling microscope light emission spectroscopy Reviewed
Satoshi Katano, Koji Toma, Mana Toma, Kaoru Tamada, Yoichi Uehara
Physical Chemistry Chemical Physics 12 ( 44 ) 14749 - 14753 2010.11
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Nanoscale coupling of photons to vibrational excitation of Ag nanoparticle 2D array studied by scanning tunneling microscope light emission spectroscopy Reviewed
Satoshi Katano, Koji Toma, Mana Toma, Kaoru Tamada, Yoichi Uehara
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 12 ( 44 ) 14749 - 14753 2010
MISC
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TOMA Mana
Oyo Buturi 89 ( 11 ) 679 - 681 2020.11
Presentations
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Plasmonic Colors on Metal Nanostructure Arrays for Spectrometer-free Plasmonic Biosensors Invited
Mana Toma
2024.9
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Spectrometer-free Plasmonic Biosensors Using Colors of Metal Nanodome Arrays Invited
Mana Toma
The 7th A3 Metamaterials forum 2023 2024.6
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Color generation in plasmonic metasurface and biosensor application Invited
Mana Toma
11th International Symposium on Organic Molecular Electronics (ISOME 2020) 2020.8
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Substrate based colorimetric biosensors using plasmonic metasurface Invited
The 14th Advanced Lasers and Photon Sources Conference (ALPS2025) 2025.4
Awards
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研究奨励賞
2020 高柳健次郎財団
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女性研究者研究業績（若手部門）
2019 応用物理学会
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優秀論文発表賞
2018 電気学会
Research Projects
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2022 - 2023
科学技術振興機構 産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) トライアウト トライアウト
當麻 真奈
Authorship：Principal investigator
本研究は、食品中のアレルギー物質を簡易かつ迅速に検出可能な食物アレルゲンセンサーの開発を目的としている。モバイル端末を用いた簡易計測手法のプロトタイプ開発を行い、食物アレルゲンの検出性能を評価する。本研究開発によって、食品アレルギー患者の健康維持および生活の質向上に貢献することを目指している。
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分子マーカーの多種類同時計測を目指したスマートフォン型バイオセンサの開発
Grant number：20K14748 2020.4 - 2023.3
日本学術振興会 科学研究費助成事業 若手研究
當麻 真奈
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
本研究は、疾病や健康状態に関わる生体分子をスマートフォン内蔵のカメラで迅速・高感度かつ定量的に検出できるバイオセンシング技術を確立することを目的としている。そのために、プラズモニック色によって発色する金属ナノ構造配列をセンサ基板表面に作製し、標的となる生体分子の捕捉によってセンサ感応部の色が変化するバイオセンサ基板を開発する。
センサ基板に用いる金属ナノ構造として、鮮やかに発色する金属ナノドームアレイ構造を作製した。これまでに、色相角度で数値化された色をセンサ信号に用いるために最適な金属ナノドームアレイ構造のパラメーターの探索を行い、溶液の屈折率変化を検出する屈折率センサとしての性能評価を行った。溶液のバルク屈折率感度測定では、比色法で優れた屈折率分解能が得られることが明らかにした。
2021年度は、提案手法のバイオセンサ性能をモデルサンプルによるイムノアッセイで評価した。同一のセンサスポットで反射分光法および反射画像からの色相角度解析する比色法による測定を行い、両手法による検出感度の差異を信号対ノイズ比および検出限界濃度を指標として評価・比較した。その結果、センサ基板表面に結合した標的分子を検出するイムノアッセイにおいても、比色法と分光法で同程度のセンサ性能が得られることが明らかとなった。また、信号増強プローブを用いない非標識な計測であっても、高感度に生体分子を検出可能であることが示された。 -
Development of highly sensitive compact fluorescence biosensor by using metal nanohole arrays
Grant number：15H06766 2015.8 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up
Toma Mana, TAWA Keiko
Grant amount：\2990000 （ Direct Cost: \2300000 、 Indirect Cost：\690000 ）
In this project, metal nano hole arrays structures are proposed for the development of highly sensitive and compact fluorescence biosensors utilizing surface plasmon enhanced fluorescence. The fabrication method of metal nanostructure array was developed, and a bio-inspired adhesive, polydopamine thin films was utilized as low-cost and simple protein linker layer of the metal sensing surfaces.