Updated on 2025/10/09

写真a

 
Tokuda Takashi
 
Organization
Institute of Integrated Research Laboratory for Future Interdisciplinary Research of Science and Technology Professor
Title
Professor
External link

Degree

  • Doctor of Engineering ( Kyoto University )

Research Interests

  • Optoelectronic Materials and Devices

  • CMOS Integrated Circuits

  • Bioelectronics

  • Image Sensors

  • Biosensors

Research Areas

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Measurement engineering

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Electric and electronic materials

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Electron device and electronic equipment

  • Life Science / Biomedical engineering

  • Life Science / Biomaterials

Education

  • 京都大学大学院   工学研究科   電子物性工学専攻 博士後期課程

    1995.4 - 1998.3

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    Country: Japan

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  • 京都大学大学院   工学研究科   電気工学専攻 修士課程

    1993.4 - 1995.4

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  • Kyoto University   Faculty of Engineering

    1989.4 - 1993.3

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    Country: Japan

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Research History

  • Tokyo Institute of Technology   Professor

    2019.4

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  • Nara Institute of Science and Technology   Associate Professor

    2008.4 - 2019.3

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  • Nara Institute of Science and Technology   Graduate School of Materials Science   Assistant Professor

    2007.4 - 2008.3

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  • Nara Institute of Science and Technology   Graduate School of Materials Science

    1999.4 - 2007.3

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  • 京都大学大学院   工学研究科   日本学術振興会特別研究員(PD)

    1998.4 - 1999.3

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Professional Memberships

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Committee Memberships

  • IEEE Sensors Journal   Associate Editor (Radiation Sensors etc)  

    2018.1   

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  • IEEE BioCAS Conference 2019   Techinical Program Co-chair  

    2018   

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    Committee type:Academic society

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  • Symposium on VLSI Circuits   Technical Program Committee Member  

    2017.7   

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    Committee type:Academic society

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  • 電気学会   神経工学に関連する将来技術調査専門委員会 委員  

    2017   

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    Committee type:Academic society

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  • 映像情報メディア学会   情報センシング研究委員会 幹事  

    2017   

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    Committee type:Academic society

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  • 電気学会   センサ・マイクロマシン部門委員会 幹事  

    2016   

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    Committee type:Academic society

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  • SSDM   Program Committee Member  

    2016   

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    Committee type:Academic society

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  • 電気学会   エレクトロバイオロジー調査専門委員会 幹事  

    2016   

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    Committee type:Academic society

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  • Electronics Letters誌   Subject Editor (Biomedical Technology)  

    2015.12   

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    Committee type:Academic society

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  • 電気学会   神経工学に関連する各種要素技術調査専門委員会 委員  

    2014 - 2017   

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    Committee type:Academic society

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  • 映像情報メディア学会   編集企画委員会 企画幹事  

    2013 - 2017   

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    Committee type:Academic society

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  • 映像情報メディア学会   情報センシング研究委員会委員  

    2013 - 2017   

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  • 電気学会   統合化バイオサーキット技術調査専門委員会 委員  

    2013 - 2016   

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    Committee type:Academic society

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  • 日本学術振興会   薄膜第131 委員会 企画委員  

    2012   

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  • 電気学会   平成25 年全国大会グループ委員会11グループ 幹事  

    2012 - 2013   

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  • 電気学会   ニューロ・エンジニアリング技術調査専門委員会 委員  

    2011 - 2013   

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  • 電気学会   半導体生体インターフェース技術調査専門委員会 委員  

    2010 - 2012   

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  • 電気学会   論文委員会(E グループ) 委員  

    2008   

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  • 電気学会   神経工学技術調査専門委員会 委員  

    2008 - 2010   

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  • 応用物理学会   プログラム編集委員(12.7担当)  

    2008 - 2010   

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  • 応用物理学会   分子・バイオエレクトロニクス分科会 幹事 (2006-2010)  

    2006 - 2010   

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  • 電気学会   インテリジェントバイオチップ技術調査専門委員会 幹事 (2006-2008)  

    2006 - 2008   

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Papers

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MISC

  • Improved voltage measurement circuit for optically-powered, battery-less microdevices

    Fukamachi Masato, Takeuchi Mizuki, Yokoshiki Yasufumi, Tokuda Takashi

    JSAP Annual Meetings Extended Abstracts   2021.1   2212 - 2212   2021.2

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    Language:Japanese   Publisher:The Japan Society of Applied Physics  

    DOI: 10.11470/jsapmeeting.2021.1.0_2212

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  • Miniaturized continuous glucose monitoring sensor driven by optical power transfer

    Miura Ryo, Maeda Daisuke, Yokoshiki Yasufumi, Tokuda Takashi

    JSAP Annual Meetings Extended Abstracts   2021.1   2213 - 2213   2021.2

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    DOI: 10.11470/jsapmeeting.2021.1.0_2213

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  • CMOS集積回路技術を用いたオンチップ光・電気イメージセンサ研究—On-Chip Opto-Electric Image Sensors Based on CMOS Technology

    德田 崇, 横式 康史, 太田 淳

    Chemical sensors = 化学センサ   36 ( 4 )   120 - 126   2020

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    Other Link: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H02222/

  • Looking within - Implantable image sensors

    K. Sasagawa, K. Sugie, M. C. Guinto, M. Haruta, T. Tokuda, J. Ohta

    Electronics Letters   55 ( 13 )   718   2019.6

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    Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1049/el.2019.1802

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  • Development of Ultra-small Implantable Optogenetic Stimulator

    TOKUDA Takashi, HARUTA Makito, NODA Toshihiko, SASAGAWA Kiyotaka, OHTA Jun

    Seibutsu Butsuri   59 ( 3 )   156 - 160   2019

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:The Biophysical Society of Japan General Incorporated Association  

    DOI: 10.2142/biophys.59.156

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  • Invited : Time-Lapse Observation of Cultured Cells by Lensless Fluorescence Imaging Invited

    42 ( 30 )   21 - 27   2018.9

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  • 生体埋め込みCMOSデバイスによる神経刺激と脳機能イメージング

    野田俊彦, 春田牧人, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会大会講演論文集(CD-ROM)   2018   ROMBUNNO.AI‐1‐2   2018.3

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  • 光電力伝送によるバッテリレス生体埋植光刺激デバイス

    川野裕祐, 石津岳明, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2018   ROMBUNNO.3‐133   2018.3

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  • 人工視覚用ハニカム型CMOSスマート電極アレイの作製

    寺田啓介, 西村信耶, 野田俊彦, 中野由香梨, 中野由香梨, 寺澤靖雄, 春田牧人, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.17p‐F306‐1   2018.3

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  • 高速撮像近赤外カラー眼底カメラに向けたオンチップ干渉フィルタの試作

    白髭大貴, 宮崎駿佑, 竹原浩成, 角博文, 笹川清隆, 春田牧人, 野田俊彦, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.17p‐F306‐4   2018.3

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  • 脳表光刺激デバイスの開発へ向けた齧歯類・霊長類脳の光学特性の測定

    長沼京介, 白石愛香里, 太田安美, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.18a‐F306‐3   2018.3

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  • レンズレス蛍光イメージング用ハイブリッド励起光除去フィルタ

    笹川清隆, 木村文香, 春田牧人, 中元健太, 池田斉人, 野田俊彦, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.17p‐P11‐11   2018.3

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  • CMOS技術によるオンチップエレクトロバイオロジー

    徳田崇, 春田牧人, 野田俊彦, 笹川清隆, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2018   ROMBUNNO.S25‐1   2018.3

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  • FRET計測用CMOSイメージングデバイスに向けたハイブリッドフィルタの開発

    亀山愛樹, 中元健太, HEE Wan‐Shen, 木村文香, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.18a‐F306‐12   2018.3

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  • 人工視覚デバイス用CMOSチップのAC駆動回路の設計

    森康登, 野田俊彦, 鐘堂健三, 寺澤靖雄, 春田牧人, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.17p‐F306‐2   2018.3

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  • グラフェン透明導電膜の電気化学発光への応用

    黒木大地, 高橋真優, 渡辺剛志, 徳田崇, 太田淳, 黄晋二

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   ROMBUNNO.17p‐P11‐32   2018.3

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  • 革新的機能をもつイメージセンサー オンチップ偏光子を用いた偏光分析CMOSイメージセンサー

    徳田崇, 春田牧人, 野田俊彦, 笹川清隆, 垣内喜代三, 太田淳

    光学   47 ( 1 )   2‐7   2018.1

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  • 小型動物用超小型イメージングデバイスによる脳疾患モデルマウスの脳血流・脳機能同時計測

    春田牧人, 倉内祐樹, 木村文香, 大澤匡弘, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    日本薬学会年会要旨集(CD-ROM)   138th ( 1 )   ROMBUNNO.S33‐2 - 201   2018

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  • 1000fps Vision System and Its Impact on Various Intelligent Applications-Next-generation Fundus Camera with High Speed Imaging-

    角博文, 宮崎駿佑, 竹原浩成, 笹川清隆, 徳田崇, 岸則政, 渡辺義浩, 鏡慎吾, 太田淳, 石川正俊

    電子情報通信学会技術研究報告   117 ( 339(OPE2017 89-115) )   125‐130   2017.11

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  • In vitro FRET計測に向けたオンチップ二色蛍光検出デバイス

    中元健太, HEE W. S, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会冬季大会講演予稿集(CD-ROM)   2017   ROMBUNNO.22C‐4   2017.11

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  • CMOSイメージセンサを用いたFRETシグナル計測用2色イメージング対応型オンチップ計測システム

    中元健太, HEE Wan Shen, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)   34th   ROMBUNNO.31pm3‐PS‐98   2017.10

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  • 脳表用光刺激デバイスの開発に向けた霊長類脳の光学シミュレーション

    白石愛香里, 太田安美, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   78th   ROMBUNNO.7a‐A502‐9   2017.8

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  • 人工視覚デバイス向け活性化IrOx電極の作製と特性評価

    藤沢匠, 野田俊彦, 春田牧人, 笹川清隆, 徳田崇, CHEN P. C, WU C. Y, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   78th   ROMBUNNO.7a‐A502‐7   2017.8

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  • 光エナジーハーベスティングによる生体埋植型光刺激デバイス

    石津岳明, WUTHIBENJAPHONCHAI Nattakarn, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   78th   ROMBUNNO.7a‐A502‐11   2017.8

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  • デジタルELISA法へ向けたレンズレスオンチップ蛍光計測システムによる蛍光観察評価

    池田斉仁, 竹原浩成, 笹川清隆, 春田牧人, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2017   ROMBUNNO.33A‐4   2017.8

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  • 生体埋植用ニードル型ADC搭載CMOSイメージセンサのノイズ特性評価

    藤本光輝, 笹川清隆, 太田安美, 春田牧人, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2017   ROMBUNNO.33A‐2   2017.8

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  • 可視及び近赤外撮像による次世代高速眼底カメラの検討

    宮崎駿佑, 竹原浩成, 角博文, 角博文, 笹川清隆, 春田牧人, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2017   ROMBUNNO.31A‐2   2017.8

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  • Multi-point imaging by using multiple implantable image sensors and near infra-red image transmitter

    速水一, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   117 ( 172(ED2017 27-35) )   37‐40   2017.8

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  • Demonstration of a thin-film-based CMOS imaging device for brain functional measurement

    山口貴大, 速水一, 須永圭紀, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   117 ( 172(ED2017 27-35) )   41‐44   2017.8

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  • 薄膜を基板とするCMOSイメージングデバイスの脳機能計測に向けた実証—Demonstration of a thin-film-based CMOS imaging device for brain functional measurement—フィジカルセンサ バイオ・マイクロシステム合同研究会 センサデバイス,MEMS,一般

    山口 貴大, 速水 一, 須永 圭紀, 春田 牧人, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳

    電気学会研究会資料. PHS   2017 ( 39-53 )   41 - 44   2017.8

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    Other Link: http://id.ndl.go.jp/bib/028512823

  • GCaMP fluorescence imaging associated with visual stimulation with implantable imaging device

    須永圭紀, 白石愛香里, 山口貴大, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 吉村由美子, 太田淳

    電気学会フィジカルセンサ研究会資料   PHS-17 ( 21-33.35-38 )   9‐10   2017.6

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  • Development of implantable CMOS imaging device for GCaMP fluorescence imaging and performance evaluation by in vivo experiment

    須永圭紀, 白石愛香里, 山口貴大, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 吉村由美子, 太田淳

    映像情報メディア学会技術報告   41 ( 19(IST2017 34-40) )   1‐3 - 3   2017.6

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  • 無機固体素子を用いたフィルム状脳内埋植用フレキシブルデバイスの開発

    山口貴大, 須永圭紀, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2017   ROMBUNNO.3‐118   2017.3

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  • 人工視覚システム用CMOSチップ内蔵網膜刺激電極の実装工程最適化と機能検証

    西村信耶, 吉村彰人, 野田俊彦, 寺澤靖雄, 中野由香梨, 春田牧人, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2017   ROMBUNNO.3‐117   2017.3

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  • ライトパイプアレイ搭載CMOSイメージセンサを用いた微小液滴チャンバーの蛍光観察

    池田斉仁, 竹原浩成, 中本悠太, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2017   ROMBUNNO.3‐115   2017.3

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  • 同軸型オプトロードを搭載した新構造CMOSベースフレキシブルBMIデバイス

    石津岳明, 岩崎聡, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2017   ROMBUNNO.3‐116   2017.3

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  • マイクロリアクタ向け不斉分析用偏光分析CMOSイメージセンサの消光性能向上

    宮崎駿佑, 中塚篤志, 中野百恵, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2017   ROMBUNNO.3‐114   2017.3

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  • 非拘束リアルタイム脳機能計測に向けた埋植型多点撮像デバイス

    速水一, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   64th   ROMBUNNO.14p‐F204‐12   2017.3

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  • CMOSイメージセンサを用いた培養細胞のレンズレスオンチップ蛍光計測システム

    中元健太, 大澤和孝, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   64th   ROMBUNNO.14p‐F204‐9   2017.3

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  • 微弱蛍光計測に向けた埋植型CMOSイメージングデバイスの作製と評価

    白石愛香里, 須永圭紀, 山浦洋, 藤本光輝, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 吉村由美子, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   64th   ROMBUNNO.14p‐F204‐1 - 2763   2017.3

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    DOI: 10.11470/jsapmeeting.2017.1.0_2763

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  • 干渉フィルタを搭載した生体埋植型蛍光観察デバイス用LED光源

    藤本光輝, 春田牧人, 太田安美, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   64th   ROMBUNNO.14p‐F204‐3   2017.3

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  • バイオセンシング・センサーの新展開 CMOS技術によるバイオセンサ・バイオチップ

    徳田崇, 太田淳

    化学工業   68 ( 2 )   113‐119 - 112   2017.2

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  • In vivo analysis of electrode-surface characteristic for evoked potential recording using electrochemical impedance spectroscopy to evaluate the safety of visual prostheses

    桑原真理子, 田代洋行, 田代洋行, 寺澤靖雄, 寺澤靖雄, 中野由香梨, 吉村優里奈, 大澤孝治, 野田俊彦, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   116 ( 435(MBE2016 69-81) )   25‐29 - 29   2017.1

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  • Next-generation fundus camera with high speed visible and near infrared imaging

    Miyazaki Shunsuke, Takehara Hironari, Sumi Hirofumi, Sasagawa Kiyotaka, Haruta Makito, Noda Toshihiko, Tokuda Takashi, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2017 ( 0 )   31A - 2   2017

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    In this paper, we propose a fundus camera based on high speed imaging at infrared wavelengths. We have fabricated near-infrared (NIR) band-pass filters and reconstructed a color image from NIR images.

    DOI: 10.11485/iteac.2017.0_31A-2

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  • Performance enhancement methods via deposition reaction for implantable metal electrode

    2016 ( 32 )   11 - 15   2016.12

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  • Implantable microelectronic devices

    徳田崇, 太田淳

    応用物理   85 ( 10 )   889‐894 - 894   2016.10

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  • 人工視覚デバイス用刺激電極の形状依存性の評価

    小部涼, 藤沢匠, 野田俊彦, CHEN Po‐Chun, 竹原宏明, 笹川清隆, 徳田崇, WU Chung‐Yu, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   ROMBUNNO.14p‐P19‐4   2016.9

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  • 光・電気フレキシブルBMIデバイスの高性能化

    岩崎聡, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   ROMBUNNO.14p‐P19‐3   2016.9

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  • 人工視覚システム用CMOSチップ内蔵スマート電極デバイスの動物実験による機能実証

    吉村彰人, 野田俊彦, 寺澤靖雄, 中野由香梨, 神田寛行, 田代洋行, 田代洋行, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   ROMBUNNO.16a‐B8‐2   2016.9

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  • 人工視覚デバイス向け3次元IrOx電極の生体組織中における特性評価

    藤沢匠, 小部涼, 野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, WU C.Y, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   ROMBUNNO.16a‐B8‐3   2016.9

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  • ハイドロゲル光導波路の開発と生体内光通信への応用

    桂木優治, 速水一, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   ROMBUNNO.16a‐B8‐1   2016.9

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  • ライトパイプアレイを搭載したレンズレスデジタルELISAシステムの蛍光検出感度評価

    中本悠太, 竹原浩成, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2016   ROMBUNNO.21E‐3   2016.8

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  • 偏光計測CMOSイメージセンサを用いたマイクロリアクタ向け不斉反応計測デバイスの性能向上

    中塚篤志, 中野百恵, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2016   ROMBUNNO.21E‐2   2016.8

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  • An Implantable Multiple Imaging Device with Intra-Body Communication Technology

    速水一, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   116 ( 181(ED2016 37-42) )   57‐60   2016.8

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  • Flexible devices for the implantable imaging systems

    山口貴大, 須永圭紀, 春田牧人, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   116 ( 181(ED2016 37-42) )   1‐4   2016.8

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  • 生体埋植用イメージングシステムに向けたフレキシブルデバイス—Flexible devices for the implantable imaging systems—電子デバイス

    山口 貴大, 須永 圭紀, 春田 牧人, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報   116 ( 181 )   1 - 4   2016.8

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    Other Link: http://id.ndl.go.jp/bib/027631619

  • Intravital optical communication using hydrogel fibers and implantable LSI chips

    竹原宏明, 桂木優治, 速水一, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-16 ( 9-20 )   27‐31   2016.6

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  • マイクロリアクタ向け偏光計測CMOSイメージセンサの性能向上

    中塚篤志, 本田眞彬, 中野百恵, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2016   ROMBUNNO.3‐111   2016.3

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  • 人工視覚デバイス用3次元IrOX電極の作製と特性評価

    小部涼, 林恵, 野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, WU Chung‐Yu, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2016   ROMBUNNO.3‐112   2016.3

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  • デジタルELISAシステムの小型化へ向けた励起光除去フィルタ充填ライトパイプアレイの開発

    中本悠太, 竹原浩成, 竹原浩成, 永崎瑞樹, 竹原宏明, 竹原宏明, 野田俊彦, 野田俊彦, 笹川清隆, 笹川清隆, 徳田崇, 徳田崇, 太田淳, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2016   ROMBUNNO.3‐110   2016.3

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  • 生体埋め込みCMOS光センサ技術による蛍光方式グルコースセンサ

    徳田崇, 竹原宏明, 野田俊彦, 笹川清隆, 興津輝, 竹内昌治, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2016   ROMBUNNO.3‐S24‐1   2016.3

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  • CMOSイメージセンサを用いた培養細胞のオンチップ蛍光計測システム

    大澤和嵩, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   ROMBUNNO.20A-W331-9   2016.3

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  • 人工視覚システム用CMOSチップ内臓スマート電極デバイスの作製と動作実証

    吉村彰人, 川崎凌平, 野田俊彦, 田代洋行, 田代洋行, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   ROMBUNNO.20A-W331-1   2016.3

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  • 埋植型デバイスへの導入に向けたハイドロゲルの光学特性評価

    桂木優治, 須永圭紀, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   ROMBUNNO.20P-W331-6 - 2789   2016.3

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    DOI: 10.11470/jsapmeeting.2016.1.0_2789

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  • 埋植型デバイスによる広範囲イメージングに向けた励起光除去性能改善

    須永圭紀, 春田牧人, 山口貴大, 桂木優治, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   ROMBUNNO.20P-W331-5 - 2788   2016.3

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    DOI: 10.11470/jsapmeeting.2016.1.0_2788

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  • 分散型アーキテクチャによる広範囲被覆可能な埋込型の光電気BMIデバイス

    岩崎聡, 野口知暉, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   ROMBUNNO.20A-W331-2   2016.3

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  • イメージセンサ技術の最新動向 4章 バイオメディカル用イメージセンサ

    笹川清隆, 春田牧人, 竹原浩成, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会誌   70 ( 2 )   271‐276 - 270   2016.3

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  • Evaluation of sensitivity of lensless digital ELISA system with light pipe array

    Nakamoto Yuta, Takehara Hironari, Sasagawa Kiyotaka, Takehara Hiroaki, Noda Toshihiko, Tokuda Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2016 ( 0 )   21E - 3   2016

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    We have developed a light pipe array and constructed a miniaturized digital ELISA system which consisted of the light pipe array, a PDMS microfluidic and a CMOS image sensor. In this work, we evaluated sensitivity of the digital ELISA system

    DOI: 10.11485/iteac.2016.0_21E-3

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  • Performance improvement of in - line chiral measurement system based on a polarization - analyzing CMOS image sensor

    NAKATSUKA Atsushi, NAKANO Momoe, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, NISHIYAMA Yasuhiro, KAKIUCHI Kiyomi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2016 ( 0 )   21E - 2   2016

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    We have developed a polarization-analyzing CMOS image sensor. We made a palm-size in-line chiral analysis device for microchemistry systems, and succeeded in real-time measurements. In this work, we designed a new polarization-analyzing device with improved performance.

    DOI: 10.11485/iteac.2016.0_21E-2

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  • Lensless CMOS Imaging Device for Fluorescent and Non-Fluorescent Imaging Dedicated to Digital ELISA

    笹川清隆, 笹川清隆, 竹原浩成, 竹原浩成, 永崎瑞樹, 竹原宏明, 竹原宏明, 野田俊彦, 野田俊彦, 徳田崇, 徳田崇, 野地博行, 野地博行, 太田淳, 太田淳

    電気学会論文誌 E   136 ( 1 )   12-17 (J-STAGE)   2016

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  • Implantable Image Sensors with Chip ID selection for Multi Area Imaging.

    速水一, 永田健悟, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-15 ( 65-69 )   1‐3   2015.12

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  • Automatic determination of blood flow velocity in brain microvessel of rat using a small implantable CMOS imaging device

    出島遼, 佐藤哲大, 春田牧人, 中澤瞳, 徳田崇, 太田淳, 金谷重彦

    電子情報通信学会技術研究報告   115 ( 301(MI2015 57-72) )   37‐41   2015.11

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  • 1分子酵素アッセイのコンタクトイメージング用マイクロライトパイプアレイ蛍光検出システム

    竹原浩成, 竹原浩成, 永崎瑞樹, 中本悠太, 笹川清隆, 笹川清隆, 竹原宏明, 竹原宏明, 野田俊彦, 野田俊彦, 徳田崇, 徳田崇, 太田淳, 太田淳

    Optics & Photonics Japan講演予稿集(CD-ROM)   2015   ROMBUNNO.30AES10   2015.10

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  • 埋植型CMOSデバイスを用いたフラビン蛋白蛍光イメージング

    須永圭紀, 山浦洋, 春田牧人, 山口貴大, 元山真由美, 太田安美, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 吉村由美子, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-8 - 2559   2015.8

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    DOI: 10.11470/jsapmeeting.2015.2.0_2559

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  • 埋植用自己リセット型CMOSイメージセンサによる内因性シグナルの検出

    山口貴大, 須永圭紀, 春田牧人, 元山真由美, 太田安美, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-9 - 2560   2015.8

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    DOI: 10.11470/jsapmeeting.2015.2.0_2560

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  • 広範囲被覆可能なCMOSベースマルチモーダル脳刺激・計測デバイスの開発

    野口知暉, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-7   2015.8

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  • 人工視覚用IrOx刺激電極の作製と特性評価

    林恵, 野田佳子, 野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, WU Chung‐Yu, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-5   2015.8

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  • STS方式人工視覚向け網膜刺激デバイスへの光検出機能の搭載

    藤沢匠, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, CHARBON Edoardo, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-4   2015.8

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  • 埋植型PWM出力イメージセンサを用いた生体内通信による画像伝送

    速水一, 永田健吾, 春田牧人, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-10   2015.8

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  • 人工視覚用CMOSチップ内蔵スマート電極デバイスの作製と負荷駆動能力の向上

    川崎凌平, 藤沢匠, 野田俊彦, 田代洋行, 田代洋行, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   ROMBUNNO.15A-2B-6   2015.8

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  • デジタル酵素結合免疫吸着法に向けた遮光層付ドロップレットアレイ搭載CMOSイメージセンサの開発

    永崎瑞樹, 竹原浩成, 竹原宏明, 野田俊彦, 野田俊彦, 笹川清隆, 笹川清隆, 徳田崇, 徳田崇, 野地博行, 野地博行, 太田淳, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2015   ROMBUNNO.14D‐3   2015.8

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  • CMOSセンサベース蛍光方式埋め込みグルコースセンサの開発

    平井智大, 河村敏和, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2015   ROMBUNNO.14D‐2   2015.8

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  • マイクロリアクタ向け偏光分析CMOSイメージセンサの機能向上

    本田眞彬, 竹原浩成, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2015   ROMBUNNO.14D‐4   2015.8

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  • LEDによる画像情報出力可能な生体埋植型イメージングデバイスの開発

    永田健悟, 速水一, 竹原宏明, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2015   ROMBUNNO.14D‐1   2015.8

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  • Automatic determination of blood flow velocity in brain microvessel of rat using a small implantable CMOS imaging device

    出島遼, 佐藤哲大, 春田牧人, 中澤瞳, 徳田崇, 太田淳, 金谷重彦

    電子情報通信学会技術研究報告   115 ( 139(MI2015 32-47) )   73 - 77   2015.7

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  • An implantable hemodynamic imaging device for observing the cerebrovascular disease

    春田牧人, 須永圭紀, 山口貴大, 竹原浩成, 太田安美, 元山真由美, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-15 ( 36-51 )   69 - 72   2015.7

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  • 脳の中を直接見る サイバーだけどパンクではありません

    徳田崇, 太田淳

    応用物理   84 ( 6 )   555 - 558   2015.6

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  • Fluorescence-based implantable Glucose Sensor with an integrated CMOS line sensor

    河村敏和, 平井智大, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会技術報告   39 ( 17(IST2015 24-34) )   31 - 33   2015.5

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    We are developing an implantable glucose sensor with a long lifetime. Recently, glucose-responsive fluorescent hydrogel whose fluorescent intensity depends on the glucose concentration was developed. We develop an implantable glucose sensor combining the hydrogel with an implantable CMOS sensor. In this work, response time was improved by an optimization of the device structure. The fabricated glucose sensor was evaluated in in vitro and in vivo experiments. An improved response performance of the sensor was confirmed.

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  • A lensless digital enzyme-linked immunosorbent assay (ELISA) system using a CMOS image sensor for fluorescence detection

    竹原浩成, 永崎瑞樹, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 野地博行, 太田淳

    映像情報メディア学会技術報告   39 ( 16(IST2015 10-23) )   33 - 36   2015.3

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    Enzyme-linked immunosorbent assay(ELISA) is a diagnosis method which is used for detecting viruses or tumor markers. A combination of antigen-antibody reactions and fluorescent reactions are utilized in ELISA. Recently, digital ELISA has been proposed to achieve higher sensitivity. We have been developing compact digital ELISA system by replacing a fluorescent microscope with a CMOS image sensor as a fluorescence detection tool. In this report, stacked photodiode CMOS image sensor for discriminating fluorescence from excitation light is proposed. A light pipe array filled with absorption filter which has high fluorescence coupling efficiency is also described.

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  • Fabrication and functional validation of a stimulus electrode with a built-in CMOS microchip for retinal prosthesis

    藤澤匠, 野田俊彦, 寺澤靖夫, 田代洋行, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-15 ( 1-8 )   13 - 17   2015.3

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  • Evaluation of an implantable CMOS imaging device for measuring green fluorescence in brain functional imaging

    須永圭紀, 春田牧人, 山口貴大, 元山真由美, 太田安美, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-15 ( 1-8 )   19 - 22   2015.3

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  • ラインセンサ型CMOSベース蛍光方式グルコースセンサの機能評価

    河村敏和, 増田啓太, 平井智大, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2015   ROMBUNNO.3-090   2015.3

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  • 人工視覚用高性能電極の開発に向けた基礎検討

    林恵, 野田佳子, 野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, WU Chung‐Yu, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2015   ROMBUNNO.3-094   2015.3

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  • 脳内埋植型CMOSイメージセンサにおける多点埋植に向けた省配線化

    速水一, 永田健悟, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2015   ROMBUNNO.3-092   2015.3

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  • マイクロリアクタ搭載に向けた偏光計測CMOSイメージセンサの機能向上

    本田眞彬, 森亮太, 増田啓太, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2015   ROMBUNNO.3-091   2015.3

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  • 広範囲被覆可能なCMOSベースマルチモーダル電気脳刺激・計測デバイスの開発

    野口知暉, 神山直也, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2015   ROMBUNNO.3-093   2015.3

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  • 埋植型PWM出力CMOSイメージセンサの低電圧化

    永田健悟, 速水一, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   62nd   ROMBUNNO.11P-D6-3   2015.2

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  • スマート電極型人工視覚デバイスの刺激電極内蔵用CMOSチップの設計

    川崎凌平, 藤沢匠, 野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   62nd   ROMBUNNO.11P-D6-6   2015.2

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  • 埋植型デバイスによる生体内蛍光イメージングの光学シミュレーション

    竹原宏明, 太田安美, 元山真由美, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   62nd   ROMBUNNO.11P-D6-5   2015.2

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  • 生体埋植用自己リセット型CMOSイメージセンサ画素の低消費電力化

    山口貴大, 須永圭紀, 春田牧人, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   62nd   ROMBUNNO.11P-D6-2 - 2624   2015.2

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    Language:Japanese   Publisher:The Japan Society of Applied Physics  

    DOI: 10.11470/jsapmeeting.2015.1.0_2624

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  • レンズレスデジタル酵素結合免疫吸着法に向けた高感度CMOSイメージセンサの設計

    永崎瑞樹, 北口一樹, 竹原浩成, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 野地博行, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   62nd   ROMBUNNO.11P-D6-1   2015.2

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  • Development of Droplet Array with Light Shielding Layer Mounted on CMOS Image Sensor for Digital ELISA

    Nagasaki Mizuki, Tokehara Hironari, Takehara Hiroaki, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Noji Hiroyuki, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2015 ( 0 )   14D - 3   2015

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    DOI: 10.11485/iteac.2015.0_14D-3

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  • Performance improvements of polarization-analyzing CMOS image sensor for micro reactor systems

    HONDA Masaaki, TAKEHARA Hironari, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, NISHIYAMA Yasuhiro, KAKIUCHI Kiyomi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2015 ( 0 )   14D - 4   2015

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    DOI: 10.11485/iteac.2015.0_14D-4

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  • Implantable Imaging Devices for Image Data Transmission Using LED Light

    NAGATA Kengo, HAYAMI Hajime, TAKEHARA Hiroaki, SASAGAWA Kiyotaka, NODA Toshihiko, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2015 ( 0 )   14D - 1   2015

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    DOI: 10.11485/iteac.2015.0_14D-1

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  • CMOSイメージセンサ搭載体内埋込み蛍光方式血糖計測デバイスの長期動作評価

    増田啓太, 高橋正幸, 河村敏和, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会冬季大会講演予稿集(CD-ROM)   2014   ROMBUNNO.7-1   2014.11

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  • Implantable bioimaging device based on CMOS image sensor technology(Next technology trends,2nd Asian Image Sensors and Imaging Systems Symposium)

    TOKUDA Takashi, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, OHTA Jun

    ITE Technical Report   38 ( 47 )   71 - 72   2014.11

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    Our studies on developing implantable devices based on CMOS image sensor technology are presented and discussed. The design of CMOS chips, packaging, experimental evaluations are described. The issues and difficulties, and future perspective are also discussed.

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  • Development of biomedical photonic devices based on CMOS sensor technology

    徳田崇, 竹原宏明, 野田俊彦, 笹川清隆, 太田淳

    電子情報通信学会技術研究報告   114 ( 323(OME2014 47-58) )   1 - 6   2014.11

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  • バイオ・医療分野に貢献するイメージセンサ レンズレスイメージングのバイオメディカル応用

    笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    Optronics   ( 395 )   102 - 106   2014.11

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  • A lensless CMOS fluorescence imaging device for single molecule detection

    笹川清隆, 竹原浩成, KIM Soo Hyeon, 山内里紗, 北口一樹, 野田俊彦, 徳田崇, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会技術報告   38 ( 37(IST2014 39-46) )   21 - 24   2014.9

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    Digital ELISA (enzyme linked immunosorbent assay) is a technique to detect fluorescence originated from a single molecule and realize concentration measurement with ultra-high sensitivity. In this study, we developed a lensless CMOS imaging device for a miniaturized digital ELISA system. By using a fabricated device, we demonstrated an enzyme assay based on fluorescence imaging.

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  • Basic study for improving the performance of implantable stimulation electrode by nanocomposite gel coating

    TASHIRO Hiroyuki, TERASAWA Yasuo, HARAGUCHI Kazutoshi, OSAWA Koji, NODA Toshihiko, TOKUDA Takashi, OHTA Jun

    IEICE technical report. ME and bio cybernetics   114 ( 213 )   39 - 43   2014.9

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    Neural interface and brain-machine interface(BMI) have been intense investigation. General technique for information transmission from machine to living body is electrical stimulation on metal electrode. If we miniaturize the size of stimulation electrode to deliver more information, the maximum injectable charge without causing tissue damage becomes less. In this study, We confirmed the feasibility of improving the performance of implantable stimulation electrode by nanocomposite(NC) gel coating. The results of the in-vitro evaluation of the platinum (Pt) electrode covered with the NC gel showed potential for enhancement of in-vivo performance by hydrophilic gel coating.

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  • 蛍光方式生体内グルコース計測技術に向けたCMOSラインセンサの開発

    河村敏和, 増田啓太, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 高橋正幸, 興津輝, 竹内昌治, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   ROMBUNNO.17A-A7-6   2014.9

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  • 人工視覚用CMOSチップ内蔵型スマート電極デバイスの刺激機能実証

    藤沢匠, 野田俊彦, 寺澤靖雄, 田代洋行, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   ROMBUNNO.17A-A7-4   2014.9

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  • マイクロ液滴アレイ観察用デュアルモードレンズレスイメージングデバイス

    笹川清隆, 北口一樹, 竹原浩成, 野田俊彦, 徳田崇, KIM Soo Hyeon, 山内里紗, 飯野亮太, 野地博行, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   ROMBUNNO.17A-A7-9   2014.9

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  • オプトジェネティクスのためのCMOSベース光・電気神経インターフェイスデバイス

    神山直也, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   ROMBUNNO.17A-A7-7   2014.9

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  • 遺伝子改変マウスの生体内蛍光イメージングに向けた埋植型イメージデバイスの開発

    竹原宏明, 太田安美, 元山真由美, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 塩坂貞夫, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   75th   ROMBUNNO.17A-A7-8   2014.9

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  • 生体埋植型PWM出力方式イメージセンサによる生体内画像伝送システムの構築

    速水一, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2014   ROMBUNNO.19-1   2014.8

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  • 自己リセット機能を備えた生体埋植用CMOSイメージセンサの開発

    山口貴大, 須永圭紀, 春田牧人, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2014   ROMBUNNO.20-1   2014.8

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  • レンズレスデジタルELISA法に向けた高感度蛍光計測用CMOSイメージセンサの設計

    北口一樹, 竹原浩成, 笹川清隆, 竹原宏明, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2014   ROMBUNNO.19-3   2014.8

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  • 表面技術とバイオ医療応用デバイス 表面コーティングによる人工視覚用電極の高性能化

    野田俊彦, 竹原宏明, 笹川清隆, 徳田崇, 太田淳

    表面技術   65 ( 6 )   257 - 261   2014.6

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    DOI: 10.4139/sfj.65.257

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  • Development of a CMOS line sensor for an implantable glucose sensor

    河村敏和, 高橋正幸, 増田啓太, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-14 ( 10-27 )   7 - 10   2014.5

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  • A design of lensless fluorescent measurement system for digital ELISA

    竹原浩成, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会技術報告   38 ( 20(IST2014 18-28) )   35 - 38   2014.5

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    Enzyme linked-immunosorbent assay (ELISA) is a diagnosis method used for early stage cancers and other diseases. Recently, digital ELISA has been proposed to achieve higher sensitivity. In order to distribute the diagnosis system widely in clinical practice, we have proposed a compact observation system. In the system, fluorescence microscope was replaced by CMOS image sensor, which can realize palmtop equipment. The properties of CMOS image sensor and fluorescence filter should be optimized for the system. We simulated the characteristics of micro pillar absorption filter surrounded by metal, which can effectively transmit fluorescence from reaction chambers to photodiodes of CMOS image sensor.

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  • Body Channel Communication by Using Implantable CMOS Image Sensor

    速水一, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会技術報告   38 ( 20(IST2014 18-28) )   21 - 24   2014.5

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    We developed a prototype of battery-powered implantable image sensor unit and successfully demonstrated its operation in phosphate buffered saline (PBS) solution as simulant body solution. We also proposed its equivalent circuit model for simulation. The measurement result of transmitted signal waveforms are in good agreement with the simulation result. Images obtained by the sensor were successfully recovered from the sensor output signal received through the PBS.

    DOI: 10.11485/itetr.38.20.0_21

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  • Improvement in the green fluorescence sensitivity of an implantable CMOS imaging device

    須永圭紀, 春田牧人, 竹原浩成, 山口貴大, 元山真由美, 太田安美, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-14 ( 1-5.7 )   21 - 24   2014.3

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  • 生体埋込みCMOSイメージセンサとグルコース応答性蛍光ハイドロゲルによる体内血糖計測デバイス

    増田啓太, 高橋正幸, 上嶋和弘, 河村敏和, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2014   ROMBUNNO.3-122   2014.3

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  • オプトジェネティクスのためのCMOSベース光刺激デバイス

    神山直也, 中島駿, 前澤安代, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2014   ROMBUNNO.3-125   2014.3

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  • 自己リセット機能を備えた高SNR生体埋植型イメージセンサ

    山口貴大, 須永圭紀, 春田牧人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2014   ROMBUNNO.3-124   2014.3

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  • CMOS集積回路技術による生体埋め込みデバイス・センサ

    徳田崇, 野田俊彦, 笹川清隆, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2014   ROMBUNNO.3-S28-5   2014.3

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  • レンズレスCMOS蛍光計測デバイスによる酵素アッセイ

    北口一樹, 宮澤和也, 山内里紗, 竹原浩成, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    電気学会全国大会講演論文集(CD-ROM)   2014   ROMBUNNO.3-123   2014.3

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  • CMOSベースマイクロバイオメディカルフォトニックデバイスの研究開発

    徳田崇, 野田俊彦, 笹川清隆, 太田淳

    電子情報通信学会大会講演論文集(CD-ROM)   2014   ROMBUNNO.C-3-29   2014.3

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  • 非接地状態埋植型CMOSイメージセンサによる生体内信号伝送

    速水一, 石井孔明, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   61st   ROMBUNNO.17A-E14-7   2014.3

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  • CMOSイメージセンサによる蛍光方式生体内グルコース計測技術の開発(II)

    河村敏和, 高橋正幸, 上嶋和弘, 増田啓太, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   61st   ROMBUNNO.17A-E14-6   2014.3

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  • AC駆動型人工視覚向け網膜刺激デバイスの駆動検証

    藤沢匠, 黒木渉平, 石井孔明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   61st   ROMBUNNO.17A-E14-8   2014.3

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  • デジタル酵素結合免疫吸着法に向けた積層フォトダイオードCMOSイメージセンサの開発

    竹原浩成, 宮澤和也, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   61st   ROMBUNNO.17A-E14-2   2014.3

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  • 生体埋植CMOSイメージングデバイスを用いた血流計測による自由行動下脳機能イメージング

    春田牧人, 須永圭紀, 山口貴大, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   61st   ROMBUNNO.18P-E15-4   2014.3

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  • 19-2 Performance Evaluation of CMOS-Based Implantable Glucose Sensor Using Fluorescent Hydrogel

    MASUDA Keita, OHTA Jun, TAKAHASHI Masayuki, KAWAMURA Toshikazu, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OKITSU Teru, TAKEUCHI Shoji

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2014 ( 0 )   19 - 2-1_-_19-2-2_   2014

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    We are developing a bio-implantable glucose-monitoring device based on complementary metal-oxide-semiconductor (CMOS) technology. We investigated basic measuring capability of the CMOS image sensor with glucose-sensitive fluorescent hydrogel in vitro and in vivo experiments. These results show our device can measure glucose concentration.

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  • 19-1 Image transmission system by using an implantable PWM image sensor

    HAYAMI Hajime, SASAGAWA Kiyotaka, TAKEHARA Hiroaki, NODA Toshihiko, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2014 ( 0 )   19 - 1-1_-_19-1-2_   2014

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    We have designed an implantable CMOS image sensor which transmits pixel values as pulse width modulated (PWM) signals to a receiver with a biological body communication method. By integrating with a triangle wave generating circuit, this sensor can reduce the number of wiring and the power consumptions in comparison with our previous device.

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  • 7-1 Long-Term Performance Evaluation of CMOS-Based Implantable Glucose Sensor Using Fluorescent Hydrogel

    MASUDA Keita, OHTA Jun, TAKAHASHI Masayuki, KAWAMURA Toshikazu, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OKITSU Teru, TAKEUCHI Shoji

    PROCEEDINGS OF THE ITE WINTER ANNUAL CONVENTION   2014 ( 0 )   7 - 1-1_-_7-1-2_   2014

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  • 20-1 Development of an implantable self-reset CMOS image sensor

    YAMAGUCHI Takahiro, SUNAGA Yoshinori, HARUTA Makito, TAKEHARA Hiroaki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2014 ( 0 )   20 - 1-1_-_20-1-2_   2014

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    We developed an implantable self-reset CMOS image sensor that can avoid pixel saturation even under intense exposure situation. Using the self-reset image sensor, we successfully observed weak fluorescence of GFP (Green Fluorescent Protein) under high intensity background.

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  • 19-3 Design of an imaging CMOS image sensor for lensless digital ELISA

    Kitaguchi Kazuki, Ohta Jun, Takehara Hironari, Sasagawa Kiyotaka, Takehara Hiroaki, Noda Toshihiko, Tokuda Takashi, Soo Hyeon Kim, Iino Ryota, Noji Hiroyuki

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2014 ( 0 )   19 - 3-1_-_19-3-1_   2014

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    Digital Enzyme Linked-ImmunoSorbent Assay(ELISA) is a method to detect highly sensitive of an antigen. Currently, a fluorescence microscope is used to measure an antigen. In this study, we designed a CMOS image sensor incorporating a Programmable Gain Amplifier(PGA) capable of amplifying pixel signals according to the intensity of background light.

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  • グルコース応答性蛍光ハイドロゲル搭載体内埋込みCMOSイメージセンサによるグルコース計測

    河村敏和, 高橋正幸, 上嶋和弘, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会冬季大会講演予稿集(CD-ROM)   2013   ROMBUNNO.11-1   2013.11

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  • Fluorescence imaging of micro droplet array by a lensless imaging device

    笹川清隆, 竹原浩成, 宮澤和也, 野田俊彦, 徳田崇, KIM Soo‐Hyeon, 飯野亮太, 野地博行, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-13 ( 35-47 )   37 - 40   2013.10

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  • Glucose sensing using bio-implantable CMOS image sensor with glucose-sensitive fluorescent hydrogel

    徳田崇, 高橋正幸, 上嶋和弘, 河村敏和, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会技術報告   37 ( 40(IST2013 42-54) )   17 - 20   2013.9

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    Glucose monitoring device using an implantable CMOS image sensor combined with glucose-sensitive fluorescence hydrogel is fabricated and demonstrated. An intensity change of fluorescence from the hydrogel was measured and we confirmed that the intensity change represents the glucose concentration.

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  • オプトジェネティクス用光デバイス

    太田淳, 徳田崇

    画像ラボ   24 ( 9 )   26 - 32   2013.9

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  • 完全埋植型CMOSイメージセンサのための電池駆動実験

    石井孔明, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-3   2013.8

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  • CMOSイメージセンサによる蛍光方式生体内グルコース計測技術の開発

    上嶋和弘, 高橋正幸, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 徳田崇, 興津輝, 竹内昌治, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-7   2013.8

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  • Digital ELISAに向けた高感度CMOSイメージセンサと画像処理によるレンズレスオンチップ蛍光計測デバイスの開発

    宮澤和也, 竹原浩成, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-1   2013.8

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  • オプトジェネティクス応用に向けたCMOSベース光‐電気神経インターフェースデバイス

    中島駿, 前澤安代, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-2   2013.8

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  • RF駆動型人工視覚向けフレキシブル網膜刺激デバイス

    徳田崇, 黒木渉平, 石井孔明, 野田俊彦, 笹川清隆, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-4   2013.8

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  • CMOSチップを電極内部に組込んだ人工視覚用スマート電極アレイの作製

    藤本裕介, 黒木渉平, 野田俊彦, 笹川清隆, 徳田崇, 寺澤靖雄, 太田淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   74th   ROMBUNNO.16A-C4-5   2013.8

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  • Glucose sensing using bio-implantable CMOS image sensor with fluorescent hydrogel

    徳田崇, 高橋正幸, 上嶋和弘, 太田安美, 元山真由美, 野田俊彦, 笹川清隆, 興津輝, 竹内昌治, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-13 ( 24-34 )   37 - 40   2013.8

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  • 励起光波長制御による生体埋植型蛍光イメージングデバイスの高感度化

    須永圭紀, 春田牧人, 元山真由美, 太田安美, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2013   ROMBUNNO.15-5   2013.8

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  • レンズレスデジタルELISAシステム向け積層フォトダイオードCMOSイメージセンサの開発

    竹原浩成, 宮澤和也, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2013   ROMBUNNO.15-7   2013.8

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  • Development of an on-chip lensless fluorescence imaging device for single-molecule digital ELISA by using image processing

    宮澤和也, 竹原浩成, 岡林大恭, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会技術報告   37 ( 22(IST2013 15-27) )   41 - 44   2013.5

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    We developed an ultra-small lensless on-chip fluorescence measurement device for a digital ELISA, which is expected as a method for very early diagnosis of cancer or infection with a virus. We succeeded in high-resolution observation by the image restoration with deconvolution processing. The field of view can be easily extended due to its lensless structure. In the future, we apply it to a digital ELISA system, which has detection sensitivity of million times higher than the conventional ELISA method, and aim to realize a molecular measurement system with ultra-high sensitive and quantitative performance.

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  • An implantable CMOS imaging device for intrinsic signal imaging of the brain

    春田牧人, 橘本力, 須永圭紀, 竹原浩成, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   37 ( 22(IST2013 15-27) )   45 - 48   2013.5

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    Observation of brain neuronal activates under freely moving condition is very important to elucidate brain functions of an animal. In this study, we developed an ultra-small implantable CMOS imaging device and successfully captured a fine image of the brain surface as implanted in a rat head. Moreover, we obtained neural responses of the primary sensory cortex according to sensory stimuli by using the implantable imaging device for intrinsic signal detection. Intrinsic signal imaging methods enable long term observation because it is not affected by bleaching and washout of stain solution. Our proposed technique realizes brain observation with low limitation of behavior under freely moving condition.

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  • Basic concept of continuous glucose monitoring using an implantable CMOS image sensor with glucose-sensitive fluorescent hydrogel

    徳田崇, 上嶋和弘, 太田安美, 元山真田美, 野田俊彦, 笹川清隆, 高橋正幸, 興津輝, 竹内昌治, 太田淳

    映像情報メディア学会技術報告   37 ( 22(IST2013 15-27) )   13 - 15   2013.5

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    Basic concept of continuous glucose monitoring using an implantable CMOS image sensor is proposed and preliminary experiments were performed. Glucose-sensitive fluorescence hydrogel was implemented onto an implantable CMOS image sensor. It was confirmed that fluorescence intensity change of the hydrogel can be detected with on-chip imaging scheme.

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  • Development of a CMOS image sensor with high sensitivity fluorescence detection for digital enzyme-linked immunosorbent assay

    竹原浩成, 宮澤和也, 岡林大恭, 笹川清隆, 野田俊彦, 徳田崇, 太田淳, KIM Soo Hyeon, 飯野亮太, 野地博行

    電気学会バイオ・マイクロシステム研究会資料   BMS-13 ( 11-14.16-17 )   5 - 8   2013.3

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  • 脊髄刺激・計測用CMOSチップ搭載スマート電極デバイスの作製と機能実証

    黒木渉平, 東丸幸江, 平松祐樹, 藤本裕介, 野田俊彦, 笹川清隆, 徳田崇, KIM G. H, 関和彦, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   60th   ROMBUNNO.28A-G17-3   2013.3

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  • CMOS集積回路を用いた体内埋め込み型グルコースセンサの開発

    上嶋和弘, 立川展也, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   60th   ROMBUNNO.28A-G17-9   2013.3

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  • 脳深部神経活動計測のための低侵襲薄型CMOSイメージデバイスの開発

    須永圭紀, 橘本力, 元山真由美, 太田安美, 野田俊彦, 笹川清隆, 徳田崇, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   60th   ROMBUNNO.28A-G17-5   2013.3

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  • オプトジェネティクス応用に向けた多機能CMOS神経インターフェイスデバイス

    中島駿, 宮谷友彰, 前澤安代, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   60th   ROMBUNNO.28A-G17-7   2013.3

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  • デジタルELISA法に向けたFiber Optic Plateと画像処理によるオンチップ蛍光計測デバイスの開発

    宮澤和也, 岡林大恭, 竹原浩成, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   60th   ROMBUNNO.28A-G17-8   2013.3

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  • 完全埋植型CMOSイメージセンサのための脳ファントム内デジタル信号伝送実験

    石井孔明, 横田昇吾, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2013 ( 3 )   163   2013.3

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  • 人工視覚用CMOSチップ搭載スマート電極アレイの作製

    藤本裕介, 黒木渉平, 平松祐樹, 東丸幸江, 野田俊彦, 笹川清隆, 徳田崇, 寺澤靖雄, 太田淳

    電気学会全国大会講演論文集   2013 ( 3 )   164   2013.3

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  • 15-5 Improvement in sensitivity of implantable fluorescent imaging device by controlling excitation light wavelength

    SUNAGA Yoshinori, HARUTA Makito, MOTOYAMA Mayumi, OHTA Yasumi, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2013 ( 0 )   15 - 5-1-_15-5-2_   2013

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    We developed an implantable CMOS imaging device for detecting weak green fluorescence in a living body such as a mouse brain. By coating an excitation filter on LEDs, we achieved excitation light transmittance of 10-5 through a fluorescent filter on the image sensor.

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  • 11-1 Development of a CMOS-Based Implantable Glucose Monitoring Device Using Glucose-Sensitive Fluorescent Hydrogel

    KAWAMURA Toshikazu, TAKEUCHI Shoji, OHTA Jun, TAKAHASHI Masayuki, UEJIMA Kazuhiro, OHTA Yasumi, MOTOYAMA Mayumi, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OKITSU Teru

    PROCEEDINGS OF THE ITE WINTER ANNUAL CONVENTION   2013 ( 0 )   11 - 1-1-_11-1-2_   2013

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    We are developing a bio-implantable glucose-monitoring device based on complementary metal-oxide-semiconductor (CMOS) technology. We investigated basic measuring capability of CMOS image sensor with glucose-sensitive fluorescent hydrogel. This result suggest that our device has capability of measuring glucose concentration.

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  • 15-7 Development of a CMOS image sensor with stacked photodiodes for lensless digital ELISA system

    Takehara Hironari, Miyazawa Kazuya, Sasagawa Kiyotaka, Noda Toshihiko, Tokuda Takashi, Kim Soo Hyeon, Iino Ryota, Noji Hiroyuki, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2013 ( 0 )   15 - 7-1-_15-7-2_   2013

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    A CMOS image sensor with stacked photodiodes has been developed to observe fluorescence in lensless digital ELISA (enzyme-linked immunosorbent assay) system. The sensor has been fabricated by using 0.18μm mixed signal CMOS process. Sensitivities of the both stacked photodiodes indicate that they can distinguish the fluorescence from excitation light which cannot be completely eliminated by an on-chip fluorescent filter.

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  • 知っておきたいキーワード 第81回 オプトジェネティクス

    徳田崇, 太田淳

    映像情報メディア学会誌   66 ( 10 )   842 - 845   2012.10

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    DOI: 10.3169/itej.66.842

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  • 65nm標準CMOSプロセスを用いた偏光分析CMOSイメージセンサの消光比評価

    若間範充, 岡林大恭, 野田俊彦, 笹川清隆, 徳田崇, 垣内喜代三, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.13A-F7-10   2012.8

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  • CMOSチップ搭載フォーク形人工視覚デバイスの作製と機能実証

    平松祐樹, 東丸幸江, 野田俊彦, 笹川清隆, 徳田崇, 寺澤靖雄, 神田寛行, 不二門尚, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.12A-H3-4   2012.8

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  • 生体内脳機能イメージング用CMOS広域計測デバイス

    春田牧人, 小林琢磨, 橘本力, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.12A-H3-1   2012.8

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  • CMOS集積回路技術による生体埋め込みデバイス

    徳田崇, 小林琢磨, 野田俊彦, 笹川清隆, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.11P-H2-6   2012.8

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  • オプトジェネティクス応用に向けたマイクロLEDアレイ搭載CMOS神経インターフェースデバイス

    宮谷友彰, SAWADSARINGKARN Yosmongkol, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.12A-H3-2   2012.8

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  • CMOS集積回路を用いた体内埋め込み型グルコースセンサの基礎検討

    立川展也, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.12A-H3-8   2012.8

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  • CMOSチップを搭載した脊髄刺激・計測デバイスの作製と機能評価

    東丸幸江, 平松祐樹, 野田俊彦, 笹川清隆, 徳田崇, 関和彦, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   ROMBUNNO.13P-F7-2   2012.8

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  • 刺入型in vivo脳神経活動計測用CMOSイメージングデバイスの開発

    橘本力, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 元山真由美, 太田安美, 石川保幸, 塩坂貞夫, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2012   ROMBUNNO.19-4   2012.8

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  • 65nmプロセスを用いた二層構造オンチップメタル偏光子搭載イメージセンサ

    岡林大恭, 若間範充, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2012   ROMBUNNO.19-2   2012.8

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  • マウス脳を通信媒体とするイメージセンサからのデジタル出力信号の無線伝送

    横田昇吾, 橘本力, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2012   ROMBUNNO.19-3   2012.8

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  • CMOS-based bio-implantable devices

    25   64 - 69   2012.7

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  • Basenad Transmission of Image Sensor Signal toward Intra-Brain Wireless Communication

    笹川清隆, 横田昇吾, 松田隆志, DAVIS Peter, ZHANG Bing, LI Keren, 小林琢磨, 野田俊彦, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   112 ( 159(ICD2012 19-30) )   53 - 57   2012.7

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  • In situ chiral analysis device with polarization-analyzing CMOS image sensor for microchemical systems

    若間範充, 松岡均, 寺尾公維, 芝田実希子, 立川展也, 野田俊彦, 笹川清隆, 徳田崇, 西山靖浩, 垣内喜代三, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-12 ( 8-17 )   11 - 14   2012.6

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  • On-chip fluorescence counting system by using a CMOS image sensor for single-molecule digital enzyme-linked immunosorbent assay

    岡林大恭, 笹川清隆, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    映像情報メディア学会技術報告   36 ( 20(IST2012 16-28) )   25 - 28   2012.5

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    In this paper, we investigate on-chip fluorescence counting system by using a CMOS image sensor for single-molecule digital enzyme-linked immunosorbent assay (ELISA). ELISA is a technique to identify the type and amount of antigen by detecting the enzyme which generates a fluorescent substance through enzyme reaction. An on-chip fluorescence measurement technique allows miniaturizing the system by removing the fluorescence microscope optics. In the present study, we fabricated a CMOS image sensor with a micro-chamber array and demonstrated on-chip fluorescence beads counting.

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  • A CMOS imaging device for multi area imaging of rat brain activities

    橘本力, 増田博之, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   36 ( 20(IST2012 16-28) )   15 - 18   2012.5

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    Implantable CMOS image sensors are expected to be a powerful tool for brain neural imaging with high spatiotemporal resolution. In this work, we focused on cooperative activities through intrabrain networks. To deal with the issue, we developed a CMOS imaging device that enables to observe neural activities in multiple area of a rat brain widely. We implanted the device into a rat brain and demonstrated in-vivo multi-area imaging of neural activities.

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  • Brain neural activity measurement with implantable imaging devices

    太田淳, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇

    電子情報通信学会技術研究報告   111 ( 497(ICD2011 145-151) )   13 - 17   2012.3

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    We demonstrate an implantable imaging device based on a CMOS image sensor technology to measure neural activities in a mouse brain. The device architecture and fundamental characteristics are presented. We also address micro-communicators as the future directions for less invasiveness by implanting multiple ultra small imaging devices in distributed manner.

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  • CMOSチップ搭載フォーク形人工視覚デバイスの作製

    平松祐樹, 東丸幸江, 北尾拓也, 伊藤卓祐, 野田俊彦, 笹川清隆, 徳田崇, 寺澤靖雄, 神田寛行, 不二門尚, 太田淳

    電気学会全国大会講演論文集   2012 ( 3 )   166   2012.3

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  • ライトガイドアレイ構造による蛍光イメージング励起光除去特性の向上

    岡林大恭, 安藤圭祐, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2012 ( 3 )   165   2012.3

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  • 65nm標準プロセスを用いた高消光比偏光分析CMOSイメージセンサ

    若間範充, 松岡均, 安藤圭祐, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2012 ( 3 )   167   2012.3

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  • オプトジェネティクス応用のための光源アレイ搭載型CMOSイメージセンサ

    宮谷友彰, 木村大志, SAWADSARINGKARN Yosmongkol, 前澤安代, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2012 ( 3 )   168   2012.3

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  • 偏光分析CMOSイメージセンサを用いたマイクロ化学システム用リアルタイム不斉計測デバイス

    立川展也, 松岡均, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 西山靖浩, 垣内喜代三, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.16A-F8-4   2012.2

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  • 脳活動多点同時測定用CMOSイメージセンサの開発

    橘本力, 増田博之, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.16P-E3-1   2012.2

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  • 脳内埋植型イメージセンサ信号送信のための電圧制御発振器の試作

    横田昇吾, 笹川清隆, 野田俊彦, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.16A-F8-6   2012.2

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  • CMOSチップを搭載した刺入型神経刺激・計測デバイスの作製

    東丸幸江, 伊藤卓祐, 北尾拓也, 平松祐樹, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.16A-F8-8   2012.2

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  • 蛍光ビーズ計数用CMOSイメージセンサの試作

    笹川清隆, 安藤圭祐, 小林琢磨, 野田俊彦, 徳田崇, KIM Soo Hyeon, 飯野亮太, 野地博行, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.15P-GP3-14   2012.2

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  • Optimization of IrOx sputtering parameter for High Efficiency Stimulus Electrode Employed in Retinal Prosthesis Device

    PAN Yi‐Li, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, KANDA Hiroyuki, FUJIKADO Takashi, OHTA Jun

    応用物理学関係連合講演会講演予稿集(CD-ROM)   59th   ROMBUNNO.18A-GP5-15   2012.2

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  • 半導体集積回路技術による生体内埋植バイオメディカルデバイス

    太田淳, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇

    日本生体医工学会大会プログラム・論文集(CD-ROM)   51st   ROMBUNNO.OS3-03-1   2012

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  • 19-4 Needle type CMOS imaging device for measuring deep brain activities

    KITSUMOTO Chikara, OHTA Jun, KOBAYASHI Takuma, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, MOTOYAMA Mayumi, OHTA Yasumi, ISHIKAWA Yasuyuki, SHIOSAKA Sadao

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2012 ( 0 )   19 - 4-1-_19-4-2_   2012

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    We propose a needle type CMOS image sensor for performing low invasive measurement of neural activities in the deep brain of a mouse. The very thin shape reduces insertion damage to nerve cells and allows real-time imaging during motor behavior.

    DOI: 10.11485/iteac.2012.0_19-4-1

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  • 19-3 Wireless Transmission of Digital Signal from Image Sensor through Mouse Brain

    Yokota Shogo, Kitsumoto Chikara, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2012 ( 0 )   19 - 3-1-_19-3-2_   2012

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    We propose and demonstrate wireless transmission through a mouse brain using the implantable micro CMOS image sensor. A digital output signal from image sensor was transmitted through a brain phantom. Images were successfully reconstructed from the received signal.

    DOI: 10.11485/iteac.2012.0_19-3-1

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  • 19-2 CMOS image sensor using 65nm process with two-layer structure on-chip metal light polarizer

    OKABAYASHI Daisuke, WAKAMA Norimitsu, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2012 ( 0 )   19 - 2-1-_19-2-2_   2012

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    We propose and demonstrate a CMOS image sensor pixel with double-layer on-chip metal grid polarizer. The extinction ratio depends on the combination of metal layers and can be improved by optimization.

    DOI: 10.11485/iteac.2012.0_19-2-1

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  • 脳深部構造のイメージングの試み

    中野直樹, 加藤天美, 野田俊彦, 太田淳, 徳田崇, 塩坂貞夫, 畠中由美子

    機能的脳神経外科   50 ( 2 )   146 - 149   2011.12

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  • 脳深部構造のイメージングの試み

    中野直樹, 加藤天美, 野田俊彦, 太田淳, 徳田崇, 塩坂貞夫, 畠中由美子

    機能的脳神経外科   50 ( 2 )   146 - 149   2011.12

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  • 有機‐無機ハイブリッドを用いた埋植型デバイス用包埋材料の作製:ポリ(ジメチルシロキサン)添加の効果

    野村加織, KIM I.Y, 菊田浩一, 徳田崇, 太田淳, 大槻主税

    日本セラミックス協会東海支部学術研究発表会講演要旨集   2011   58   2011.12

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  • Development of in situ imaging probe for surgical operation of deep brain stimulation

    Toshihiko Noda, Toshihiko Noda, Pan Yi-Li, Pan Yi-Li, Ayato Tagawa, Ayato Tagawa, Takuma Kobayashi, Takuma Kobayashi, Kiyotaka Sasagawa, Kiyotaka Sasagawa, Takashi Tokuda, Takashi Tokuda, Yumiko Hatanaka, Yumiko Hatanaka, Naoki Nakano, Naoki Nakano, Amami Kato, Amami Kato, Sadao Shiosaka, Sadao Shiosaka, Jun Ohta, Jun Ohta

    IEEJ Transactions on Sensors and Micromachines   131 ( 12 )   427 - 428   2011.12

  • 埋植型デバイスコーティング用有機‐無機ハイブリッドの合成:金属アルコキシド添加の効果

    野村加織, KIM Ill Yong, 菊田浩一, 徳田崇, 太田淳, 大槻主税

    日本バイオマテリアル学会大会予稿集   33rd   130   2011.11

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  • Multi-functional CMOS Image Sensor for Optogenetics

    木村大志, SAWADSARINGKARN Yosmongkol, 中島新, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   35 ( 47(IST2011 69-77) )   33 - 36   2011.11

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    We developed a novel neural interface device with CMOS biosensor technology for target application in optogenetics which have shown drastic improvement in recent years. Specifically, we developed on-chip type small biosensor with an array of light-emitting diodes. We expect to apply the device for on-chip biological imaging with local optical stimulation realized by the addressing function of the chip. In this report, we describe the design and characterization of the device.

    DOI: 10.11485/itetr.35.47.0_33

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  • イメージセンサのバイオ医療応用最前線 マウス脳内イメージング

    小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 塩坂貞夫, 太田淳

    Optronics   30 ( 358 )   99 - 104   2011.10

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  • An Implantable Micro-Communicator-Toward a bio-semiconductor interface device with ultra-low invasiveness-

    太田淳, 笹川清隆, 小林琢磨, 野田俊彦, 徳田崇, 塩坂貞夫, DAVIS Peter, 松田隆志, ZHANG Bing, LI Keren

    映像情報メディア学会技術報告   35 ( 37(IST2011 51-57) )   11 - 14   2011.9

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    A ultra-micro chip with almost the same size as neuron cells can stimulate neuron cells and measure their activities in very low invasiveness. Such actions can be interpreted as a communication with living cells and a semiconductor chip, which opens a new door for a bio-abio interface system. We propose a μ-communicator (μ-COM) for such an interface chip and describe the fundamental measurement system for neural activities as well as demonstrating a preliminary experiment of intra-communication inside a mouse brain.

    DOI: 10.11485/itetr.35.37.0_11

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  • CMOS bioimage sensor with integrated micro light source array for optogenetics

    TOKUDA T, KIMURA H, SAWADSARINGKARN Y, MAEZAWA Y, KOBAYASHI T, NODA T, SASAGAWA K, OHTA J

    電気学会研究会資料. MBE, 医用・生体工学研究会   2011 ( 112 )   107 - 108   2011.9

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  • フローリアクターを用いたジアステレオ選択的光反応のオンライン観察

    寺尾公維, 松岡均, 西山靖浩, 徳田崇, 野田俊彦, 笹川清隆, 太田淳, 垣内喜代三

    光化学討論会講演要旨集   2011   32   2011.9

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  • CMOSチップ裏面に刺激電極を搭載したスマート人工視覚デバイスの作製と機能実証

    北尾拓也, 伊藤卓祐, 野田俊彦, 笹川清隆, 徳田崇, 神田寛行, 田代洋行, 寺澤靖雄, 不二門尚, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   72nd   ROMBUNNO.30A-ZG-6   2011.8

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  • 脳内多点観測を目指した順次駆動型CMOSイメージセンサ

    増田博之, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   72nd   ROMBUNNO.30A-ZG-9   2011.8

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  • CMOSチップ搭載脳刺激・計測用インテリジェント電極アレイの作製

    伊藤卓祐, 北尾拓也, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   72nd   ROMBUNNO.30A-ZG-7   2011.8

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  • オプトジェネティクス応用を目指したマイクロ光源アレイ搭載CMOSバイオイメージセンサ

    木村大志, SAWADSARINGKARN Yosmongkol, 中島新, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   72nd   ROMBUNNO.30A-ZG-3   2011.8

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  • 偏光分析CMOSイメージセンサを用いたin situ不斉計測への応用

    松岡均, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 西山靖浩, 垣内喜代三, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2011   ROMBUNNO.14-7   2011.8

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  • 無線脳内通信によるマウス脳内画像伝送

    笹川清隆, 松田隆志, DAVIS Peter, ZHANG Bing, LI Keren, 小林琢磨, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2011   ROMBUNNO.14-10   2011.8

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  • 65nmプロセスによる偏光計測イメージセンサの機能向上

    安藤圭祐, 松岡均, 小田有城, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2011   ROMBUNNO.14-8   2011.8

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  • Wireless Transmission of Image Signal through Mouse Brain

    笹川清隆, 松田隆志, DAVIS Peter, ZHANG Bing, LI Keren, 小林琢磨, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会技術報告   35 ( 28(IST2011 44-50) )   19 - 23   2011.7

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  • An intelligent bio-interface device integrated with CMOS microchips

    野田俊彦, 北尾拓也, 伊藤卓祐, 笹川清隆, 徳田崇, 神田寛行, 田代洋行, 寺澤靖雄, 不二門尚, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-11 ( 8-18 )   17 - 21   2011.6

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  • 機能神経外科に関係する画像診断の進歩 脳深部構造のイメージングの試み

    中野 直樹, 加藤 天美, 野田 俊彦, 太田 淳, 徳田 崇, 塩坂 貞夫, 畠中 由美子

    機能的脳神経外科   50 ( 1 )   22 - 23   2011.6

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  • Improvement of spatial resolution by light guide array structure for in vivo fluorescent imaging

    安藤圭祐, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   35 ( 19(IST2011 17-32) )   45 - 47   2011.5

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    Implantation of a CMOS image sensor into the brain of a living animal can realize neural activity imaging in a deep brain with high spatio-temporal resolution. We have successfully demonstrated that employing a light guide array structure on a sensor improves a spatial resolution, even if without any optics such as a micro lens array. Fluorescence imaging of a mouse brain slice is demonstrated by using the fabricated sensor.

    DOI: 10.11485/itetr.35.19.0_45

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  • Development of polarization-analyzing CMOS image sensor and application to real-time chiral analysis

    松岡均, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 西山靖浩, 垣内喜代三, 太田淳

    映像情報メディア学会技術報告   35 ( 19(IST2011 17-32) )   21 - 24   2011.5

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    Perfomance of polarization-analyzing CMOS image sensor was improved by using multiple polarization-analyzing pixel array sets. The accuracy of polarization analysis was improved to σ=0.0061deg. Using the present CMOS sensor, real-time chiral analysis of menthol solution was successfully measured.

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  • An optoelectronic CMOS image sensor for electrophysiological study of a mouse brain slice

    中島新, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 石川保幸, 塩坂貞夫, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-11 ( 1-7 )   35 - 39   2011.3

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  • マイクロフローシステムを用いたジアステレオ選択的[2+2]光付加環化反応のin situ観察による精密制御

    寺尾公維, 藤岡侑司, 西山靖浩, 森本積, 徳田崇, 野田俊彦, 笹川清隆, 太田淳, 垣内喜代三

    日本化学会講演予稿集   91st ( 4 )   1284   2011.3

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  • Fabrication of High Efficiency IrOx Stimulation Electrode by Sputter Deposition

    PAN Yi‐Li, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.26A-CB-10   2011.3

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  • 凸形刺激電極とCMOSチップを搭載したフレキシブル人工視覚デバイスの作製と機能実証

    野田俊彦, 冨松慎吾, 村上歩, 佐川祐樹, 北尾拓也, 伊藤卓祐, 寺澤靖雄, 田代洋行, 神田寛行, 笹川清隆, 徳田崇, 不二門尚, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.26A-CB-9   2011.3

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  • in vivo蛍光イメージセンサへのスリット加工光ファイバ搭載による励起光広域照射

    増田博之, 水田裕樹, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.26A-CB-3   2011.3

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  • 1分子デジタル計数への応用を目指したマルチファンクショナルCMOSイメージセンサ

    木村大志, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.27A-CB-2   2011.3

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  • Implementation of dual-Color Mosaic Filter on Biomedical Photonic LSI (BpLSI) for Fluorescent Imaging

    SAWADSARINGKARN Yosmongkol, KOBAYASHI Takuma, KOBAYASHI Takuma, NODA Toshihiko, NODA Toshihiko, SASAGAWA Kiyotaka, SASAGAWA Kiyotaka, TOKUDA Takashi, TOKUDA Takashi, OHTA Jun, OHTA Jun

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.26A-CB-4   2011.3

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  • CMOSチップ搭載脳刺激・計測用スマート電極デバイス

    伊藤卓祐, 北尾拓也, 佐川祐樹, 冨松慎吾, 村上歩, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   58th   ROMBUNNO.26A-CB-8   2011.3

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  • μTAS搭載用偏光分析CMOSイメージセンサの機能向上

    松岡均, 藤岡侑司, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 西山靖浩, 垣内喜代三, 太田淳

    電気学会全国大会講演論文集   2011 ( 3 )   154   2011.3

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  • 貫通コンタクト電極型人工視覚デバイスの作製と機能実証

    北尾拓也, 伊藤卓祐, 佐川祐樹, 冨松慎吾, 村上歩, 野田俊彦, 笹川清隆, 徳田崇, 神田寛行, 田代洋行, 寺澤靖雄, 不二門尚, 太田淳

    電気学会全国大会講演論文集   2011 ( 3 )   151   2011.3

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  • ライトガイドアレイ構造によるマウス脳スライスの高空間分解能イメージング

    安藤圭祐, 種子田浩志, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2011 ( 3 )   150   2011.3

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  • A CMOS image sensor with light guide array structure for in-vivo fluorescent imaging of brain neural activities

    笹川清隆, 安藤佳祐, 種子田浩志, 水田裕樹, 田川礼人, 小林琢磨, 野田俊彦, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   110 ( 437(OPE2010 167-183) )   13 - 16   2011.2

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    We fabricated an implantable CMOS image sensor with light guide array structure for improvement of spatial resolution and sensitivity of fluorescent imaging in a brain. By using a thin light guide array, it is possible to improve spatial resolution with low invasiveness to living tissue. In this paper, we report on the limitation of incident angle into the sensor and wavelength selectivity by the image sensor with light guide array and interference filter.

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  • CMOSイメージセンサのバイオメディカル応用 脳内埋植CMOSイメージセンサ

    笹川清隆, 小林琢磨, 野田俊彦, 徳田崇, 太田淳

    機能材料   31 ( 2 )   24 - 32   2011.1

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  • 14-8 Development of polarization-analyzing CMOS image sensor using 65nm process

    ANDO Keisuke, MATSUOKA Hitoshi, ODA Yuki, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2011 ( 0 )   14 - 8-1-_14-8-2_   2011

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    We propose a polarization analyzing image sensor pixel based on 65-nm CMOS process. The polarizer is designed by using a metal layer. The designed pixel structure and characteristics are described. By the fabricated sensor, extinction ratio greater than 90 is successfully achieved.

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  • 14-7 Real-time chiral analysis using polarization-analyzing CMOS image sensor

    Matsuoka Hitoshi, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Terao Kimitada, Nishiyama Yasuhiro, Kakiuchi Kiyomi, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2011 ( 0 )   14 - 7-1-_14-7-2_   2011

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    Perfomance of polarization-analyzing CMOS image sensor was improved by using multiple polarization-analyzing pixel array sets. The accuracy of polarization analysis was improved to σ=0.0061deg. Using the present CMOS sensor, real-time chiral analysis of menthol solution was successfully measured.

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  • Biomedical devices based on semiconductor microelectronics technologies Reviewed

    Jun Ohta, Ohta, J., Kobayashi, T., Noda, T., Sasagawa, K., Tokuda, T.

    IEEJ Transactions on Sensors and Micromachines   131 ( 12 )   404-408 (J-STAGE) - 408   2011

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    DOI: 10.1541/ieejsms.131.404

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  • CMOS imaging device for optical imaging of biological activities Reviewed

    Jun Ohta, Shishido, S., Oguro, Y., Noda, T., Sasagawa, K., Tokuda, T., Ohta, J.

    IEEJ Transactions on Electronics, Information and Systems   131 ( 1 )   76-82 (J-STAGE) - 82   2011

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    DOI: 10.1541/ieejeiss.131.76

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  • 標準プロセスによる偏光分析CMOSイメージセンサの機能向上

    徳田崇

    映像メディア学会誌   65 ( 3 )   367 - 370   2011

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  • 14-10 Image Transmission through a mouse brain by wireless intra-brain communication

    SASAGAWA Kiyotaka, MATSUDA Takashi, DAVIS Peter, Zhang Bing, Li Keren, KOBAYASHI Takuma, NODA Toshihiko, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2011 ( 0 )   14 - 10-1-_14-10-2_   2011

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    We propose and demonstrate wireless intra-brain communication. By using a brain as a transmission medium, low power communication is realized. An image from an image sensor is successfully transmitted through a mouse brain.

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  • 超小型CMOSチップを分散配置したフレキシブル人工視覚デバイスの開発

    野田俊彦, 佐川祐樹, 村上歩, 冨松慎吾, 笹川清隆, 徳田崇, 西田健太郎, 不二門尚, 太田淳

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)   27th   ROMBUNNO.A4-1   2010.10

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  • On-chip voltage-sensitive dye imaging of primary cultured cortical neurons using biomedical photonic LSI

    KOBAYASHI Takuma, TAGAWA Ayato, SAWADSARINGKARN Yosmongkol, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, HATANAKA Yumiko, TAMURA Hideki, ISHIKAWA Yasuyuki, SHIOSAKA Sadao, OHTA Jun

    2010 ( 129 )   69 - 72   2010.9

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  • バイオメディカルフォトニックLSIによる培養神経細胞のオンチップ電位感受性色素イメージング

    小林琢磨, 田川礼人, SAWADSARINGKARN Yosmongkol, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    生体・生理工学シンポジウム論文集   25th ( 129 )   189 - 192   2010.9

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  • Performance Improvements of Polarization-Analyzing Image Sensor using 65nm CMOS process

    宍戸三四郎, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   34 ( 38(IST2010 42-47) )   25 - 28   2010.9

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    Development of the CMOS process enables implementation of sub-wavelength structures. To improve the extinction ratio of polarization analyzing image sensor, we designed and fabricated the sensor with fine metal grid polarizers using 65nm CMOS process. By the fabricated sensor, extinction ratio greater than 40 is successfully achieved.

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  • メタルナノスリットアレイを用いたin‐vivo蛍光イメージセンサの空間分解能向上法の検討

    笹川清隆, 野田俊彦, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   71st   ROMBUNNO.16A-ZW-27   2010.8

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  • 貫通コンタクト構造とハイブリッド樹脂を利用した人工視覚デバイスの実装

    村上歩, 佐川祐樹, 冨松慎吾, 野田俊彦, 笹川清隆, 徳田崇, KIM I.Y, 大槻主税, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   71st   ROMBUNNO.16A-ZW-23   2010.8

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  • リアルタイム不斉計測に向けた偏光分析CMOSイメージセンサの開発

    藤岡侑司, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 西山靖浩, 堤健, 垣内喜代三, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   71st   ROMBUNNO.16A-ZW-28   2010.8

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  • バイオメディカルフォトニックLSIによる生体脳視覚野における神経細胞の電位イメージング

    小林琢磨, 田川礼人, SAWADSARINGKARN Yosmongkol, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学会学術講演会講演予稿集(CD-ROM)   71st   ROMBUNNO.16A-ZW-26   2010.8

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  • 干渉フィルタおよびライトガイドアレイを搭載したin‐vivo用蛍光イメージセンサ

    笹川清隆, 種子田浩志, 野田俊彦, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2010   ROMBUNNO.5-10   2010.8

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  • 65nm CMOSプロセスでの偏光計測イメージセンサの開発

    宍戸三四郎, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2010   ROMBUNNO.5-11   2010.8

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  • Design and Development of Polarization-Analyzing Image Sensor using 65nm CMOS Process

    宍戸三四郎, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   110 ( 140(ICD2010 21-38) )   111 - 114   2010.7

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    To realize a miniaturization of sensor chip for μTAS, we propose a polarization analyzing image sensor as a function in μTAS using 65nm CMOS process for the first time. We describe the design details and characterization of our proposed CMOS image sensor. By the fabricated sensor, polarization characteristics are successfully measured.

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  • Fabrication of high performance stimulus electrodes employed in a CMOS chip for retinal prosthesis

    野田俊彦, 冨松慎吾, 笹川清隆, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-10 ( 7-27 )   63 - 67   2010.6

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  • Implantable smart CMOS image sensor for functional imaging in deep brain

    田川礼人, 水田裕樹, 種子田浩志, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会技術報告   34 ( 19(IST2010 22-28) )   21 - 24   2010.5

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    We have developed a multimodal CMOS sensor device embedded with Au electrodes for fluorescent imaging and cell stimulation in the deep brain of mice. The Au electrodes were placed on the pixel array of the image sensor. Windows over the photodiodes (PDs) were opened in the electrode area for simultaneous fluorescent imaging and cell stimulation in the same area of the brain tissue. The experimental results showed that the 90×90μm^2 Au electrodes with windows were capable of injecting theta burst stimulation (TBS)-like current pulses at 0.2-1mA in a saline solution. We successfully demonstrated that fluorescent imaging and TBS-like current injection can be simultaneously performed in the electrode area of a brain phantom.

    DOI: 10.11485/itetr.34.19.0_21

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  • 自由行動下マウス用マルチモーダルin vivo脳神経イメージングデバイスの開発

    野田俊彦, 田川礼人, 南裕樹, 笹川清隆, 徳田崇, 太田淳

    電気学会全国大会講演論文集   2010 ( 3 )   181   2010.3

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  • スマート電極型人工視覚デバイスの動物実験による機能実証

    村上歩, 佐川祐樹, 冨松慎吾, 竹内陽一, 野田俊彦, 笹川清隆, 徳田崇, 西田健太郎, 不二門尚, 田野保雄, 太田淳

    電気学会全国大会講演論文集   2010 ( 3 )   180   2010.3

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  • 偏光分析CMOSイメージセンサを用いたインライン不斉計測システムの開発

    藤岡侑司, 下畠弘也, 野田俊彦, 笹川清隆, 徳田崇, 寺尾公維, 堤健, 垣内喜代三, 太田淳

    電気学会全国大会講演論文集   2010 ( 3 )   178   2010.3

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  • 脳内埋め込み型CMOSイメージセンサを用いたin vivo脳機能イメージングシステムの開発

    水田裕樹, 南裕樹, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 塩坂貞夫, 石川保幸, 太田淳

    電気学会全国大会講演論文集   2010 ( 3 )   179   2010.3

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  • in vivo脳神経CMOSイメージセンサにおけるフィルタ性能の改善とライトガイドアレイ構造による高解像度化

    種子田浩志, 水田裕樹, 三谷昌弘, 南裕樹, 田川礼人, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-16   2010.3

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  • ウサギ動物実験による同時多点刺激対応人工視覚デバイスの機能実証

    冨松慎吾, 佐川祐樹, 村上歩, 竹内陽一, 野田俊彦, 笹川清隆, 徳田崇, 西田健太郎, 不二門尚, 田野保雄, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-10   2010.3

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  • バイオメディカルフォトニックLSIによる培養神経細胞のオンチップ電位イメージング

    小林琢磨, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-6   2010.3

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  • CMOSチップ搭載フレキシブル人工視覚デバイスの同時多点刺激対応と脳刺激・計測デバイスへの展開

    佐川祐樹, 冨松慎吾, 村上歩, 竹内陽一, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-11   2010.3

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  • In vitro神経活動イメージングのための平面多点電極アレイ一体型CMOSイメージセンサの開発

    中島新, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-12   2010.3

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  • in vivo脳神経イメージングデバイスのワイヤレス化の検討

    桑山将和, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学関係連合講演会講演予稿集(CD-ROM)   57th   ROMBUNNO.17P-ZD-17   2010.3

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  • 5-11 Design of Polarization-Analyzing Image Sensor in 65nm CMOS Process

    SHISHIDO Sanshiro, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2010 ( 0 )   5 - 11-1-_5-11-2_   2010

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    To realize a miniaturization of the sensor chip for μTAS system, we propose a polarization analyzing image sensor using 65nm CMOS process for the first time. We describe the design details and characterization of our proposed CMOS image sensor. By the fabricated sensor, polarization property is successfully measured.

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  • 5-10 In-vivo fluorescent image sensor with interference filter and light guide array

    SASAGWA Kiyotaka, TANEDA Hiroshi, NODA Toshihiko, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2010 ( 0 )   5 - 10-1-_5-10-2_   2010

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    We fabricated an in-vivo fluorescent image sensor with an interference filter and a light guide array. We demonstrate improvement of spatial resolution and fluorescent imaging by the sensor.

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  • Design and Development of Polarization-Analyzing Image Sensor using 65nm CMOS Process

    Shishido Sanshiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   34 ( 0 )   111 - 114   2010

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    To realize a miniaturization of sensor chip for μTAS, we propose a polarization analyzing image sensor as a function in μTAS using 65nm CMOS process for the first time. We describe the design details and characterization of our proposed CMOS image sensor. By the fabricated sensor, polarization characteristics are successfully measured.

    DOI: 10.11485/itetr.34.29.0_111

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  • バイオメディカルフォトニックLSIによる神経細胞の電位イメージング

    小林琢磨, 田川礼人, SAWADSARINGKARN Yosmongkol, 野田俊彦, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    生化学   ROMBUNNO.1P-0875   2010

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  • Development of multi-functional CMOS image sensor for imaging of brain activities

    Shishido Sanshiro, Oguro Yasuhiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   33 ( 56 )   1 - 4   2009.12

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    When an operation of epilepsy to remove an epileptic focus, electroencephalogram (EEG) recordings by using disc electrodes placed on the brain surface are usually performed. It is important to compare a number of measurement results of the brain functions for reliability improvement. Based on such backgrounds, we propose and develop a multi-functional CMOS image sensor device for imaging of brain activities by an adoption of an optical imaging method which is one of the in vivo recording methods. In this report, we describe the design details and characterization of the sensors.

    DOI: 10.11485/itetr.33.56.0_1

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  • Design of CMOS Image Sensor for Highly Sensitive Electro-Optic Imaging

    藤原正英, 笹川清隆, 徳田崇, 太田淳

    Optics & Photonics Japan講演予稿集   2009   176 - 177   2009.11

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  • Development of CMOS image sensors for fluorescence observation in the deep brain of a freely moving mouse : device implementation and fluorescent measurement for in vivo imaging

    Minami Hiroki, Tagawa Ayato, Mitani Masahiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   33 ( 49 )   27 - 30   2009.11

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    We are investigating CMOS image sensors which can be directly implanted in the deep brain of mouse for observation neural activities through fluorescence. LED, color filter and infusion cannula was integrated on the sensor module to observe fluorescence in the brain of mouse. Fabricated sensor was evaluated with a brain phantom, fluorescence of AMC (7-Amino4-MethylCoumarine) excited by UV-LED was successfully observed.

    DOI: 10.11485/itetr.33.49.0_27

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  • CMOS image sensor for optical measurement of cranial nerve activity

    Oguro Yasuhiro, Shishido Sanshiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   33 ( 39 )   35 - 38   2009.10

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    Intrinsic Optical Signal (IOS) indicates activities of brain neurons, and is one of the optical imaging methods, which records in vivo activities of cerebral cortical neurons. We designed two types of CMOS image sensor devices using 0.35-μm standard CMOS process for IOS imaging. In this paper, we describe the design details, device packaging and characterization of the sensors.

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  • Development of a multifunctional CMOS image sensor for in vivo sensing of neural activities in a mouse deep brain

    Tagawa Ayato, Minami Hiroki, Mitani Masahiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   33 ( 39 )   39 - 43   2009.10

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    We developed a multimodal CMOS image sensor includes an pixel array, electrodes, and LED. The electrodes were placed on the pixel array. Windows were opened in the electrode over the photodiodes to enable the fluorescence to be imaged using the pixels under the electrodes. An LED was mounted on the chip for miniaturization and the sensor chip was shaped like a shank to facilitate smooth insertion into the brain tissue. In a brain phantom, the change in the electrical potential was successfully sensed by the electrode, and green fluorescent beads were simultaneously imaged using the pixels under the electrode. We also demonstrated that the device could successfully operate in deep brain of an anesthetized mouse.

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  • Development of a multifunctional CMOS image sensor for in vivo sensing of neural activities in a mouse deep brain

    TAGAWA Ayato, MINAMI Hiroki, MITANI Masahiro, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    IEICE technical report   109 ( 214 )   39 - 43   2009.9

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    We developed a multimodal CMOS image sensor includes an pixel array, electrodes, and LED. The electrodes were placed on the pixel array. Windows were opened in the electrode over the photodiodes to enable the fluorescence to be imaged using the pixels under the electrodes. An LED was mounted on the chip for miniaturization and the sensor chip was shaped like a shank to facilitate smooth insertion into the brain tissue. In a brain phantom, the change in the electrical potential was successfully sensed by the electrode, and green fluorescent beads were simultaneously imaged using the pixels under the electrode. We also demonstrated that the device could successfully operate in deep brain of an anesthetized mouse.

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  • CMOS image sensor for optical measurement of cranial nerve activity

    OGURO Yasuhiro, SHISHIDO Sanshiro, NODA Toshihiko, SASAGAWA Kiyotaka, TOKUDA Takashi, OHTA Jun

    IEICE technical report   109 ( 214 )   35 - 38   2009.9

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    Intrinsic Optical Signal (IOS) indicates activities of brain neurons, and is one of the optical imaging methods, which records in vivo activities of cerebral cortical neurons. We designed two types of CMOS image sensor devices using 0.35-μm standard CMOS process for IOS imaging. In this paper, we describe the design details, device packaging and characterization of the sensors.

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  • Demonstration of light-controlled retinal stimulation using CMOS multi-chip retinal prosthesis device on rabbit's retina

    TOKUDA Takashi, TAKEUCHI Yoichi, NODA Toshihiko, SASAGAWA Kiyotaka, NISHIDA Kentaro, KITAGUCHI Yoshiyuki, FUJIKADO Takashi, TANO Yasuo, OHTA Jun

    2009 ( 80 )   63 - 64   2009.9

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  • 受光機能搭載CMOSマルチチップ人工視覚デバイスによるウサギ網膜刺激

    徳田崇, 竹内陽一, 野田俊彦, 笹川清隆, 西田健太郎, 北口義之, 不二門尚, 田野保雄, 太田淳

    生体・生理工学シンポジウム論文集   24th ( 80 )   171 - 172   2009.9

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  • 第二高調波発生による4逓倍光2トーン信号生成

    笹川清隆, 藤原正英, 野田俊彦, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   70th ( 3 )   1111   2009.9

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  • マウス脳深部神経活動の蛍光・電位デュアルイメージング用CMOSセンサの開発

    田川礼人, 南裕樹, 三谷昌弘, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   70th ( 3 )   1200   2009.9

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  • 不斉度計測のための偏光分析CMOSイメージセンサの高精度化

    下畠弘也, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   70th ( 3 )   1201   2009.9

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  • 分散型人工視覚デバイス用CMOS刺激チップの高電圧化

    掛田哲宏, 竹内陽一, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   70th ( 3 )   1199   2009.9

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  • 人工シナプスに向けたCMOSチップ駆動型流体吐出マイクロデバイスの開発

    皆川亨介, 野田俊彦, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   70th ( 3 )   1200   2009.9

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  • 11-6 CMOS image sensor for recording of brain activities using optical imaging method

    Shishido Sanshiro, Oguro Yasuhiro, Noda Toshihiko, Sasagawa Kiyotaka, Tokuda Takashi, Shiosaka Sadao, Kato Amami, Ohta Jun

    Proceedings of the ... ITE annual convention   2009 ( 2009 )   "11 - 6-1"-"11-6-2"   2009.8

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    Intrinsic optical signal (IOS) indicates activities of cerebral cortical neurons in the optical imaging method, which is one of the in vivo recording methods of activities of cerebral cortical neurons. We propose the IOS imaging method for craniotomy procedure. We designed a prototype CMOS image sensor device using 0.35-μm CMOS standard process for in vivo IOS imaging. The sensor device enables multi-functional recording of brain activities such as IOS, EEG, area image, electrical stimulation in order to improve reliability of diagnosis and allows simple measurement setup.

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  • in vivo脳計測用マルチモーダルCMOSイメージセンサの開発

    野田俊彦, 田川礼人, 南裕樹, 三谷昌弘, 笹川清隆, 徳田崇, 田村英紀, 畠中由美子, 石川保幸, 塩坂貞夫, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2009   ROMBUNNO.11-7   2009.8

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  • 光計測法を用いた脳機能活動のCMOSイメージセンサの研究

    宍戸三四郎, 小黒康裕, 野田俊彦, 笹川清隆, 徳田崇, 塩坂貞夫, 加藤天美, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2009   ROMBUNNO.11-6   2009.8

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  • Polarization-analyzing CMOS image sensor with embedded wire-grid structures

    TOKUDA Takashi, YAMADA Hirofumi, SHIMOHATA Hiroya, SASAGAWA Kiyotaka, OHTA Jun

    ITE Technical Report   33 ( 30 )   17 - 20   2009.7

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    A polarization-analyzing CMOS sensor with an image sensor architecture was proposed and demonstrated. The sensor has a feature of monolithically embedded polarizer. We designed a prototype sensor equipped with a polarization-analyzing pixel array based on the concept. Embedded polarizers with different angle were implemented to realize a real-time absolute measurement of incident polarization angle. We characterized the functionality and performance of the designed polarization-analyzing CMOS image sensor.

    DOI: 10.11485/itetr.33.30.0_17

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  • Retinal stimulator embedded with light-sensing function in distributed microchip architecture for subretinal implantation

    Ohta Jun, Tokuda Takashi, Sasagawa Kiyotaka, Takeuchi Yoichi, Nishida Kentaro, Kitaguchi Yoshiyuki, Kamei Motohiro, Fujikado Takashi, Tano Yasuo

    ITE Technical Report   33 ( 30 )   21 - 24   2009.7

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    We have developed retinal stimulator embedded with light-sensing function in distributed microchip architecture for subretinal implantation. The fabricated device was implanted in a rabbit eye ball and successfully worked.

    DOI: 10.11485/itetr.33.30.0_21

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  • Contrast improvement of in-vivo imaging using a complementary-metal-oxide-semiconductor image sensor

    Sasagawa Kiyotaka, Tagawa Ayato, Minami Hiroki, Noda Toshihiko, Tokuda Takashi, Hatanaka Yumiko, Tamura Hideki, Shiosaka Sadao, Ohta Jun

    ITE Technical Report   33 ( 23 )   33 - 36   2009.6

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    Fluorescent imaging by using a complementary-metal-oxide-semiconductor image sensor is expected to be useful for observation of freely moving animals. In the in-vivo imaging of a mouse brain with an implanted image sensor, high contrast images are obtained only at around the excitation light source because of its inhomogeneous illumination. In this paper, we report on improvement of imaging dynamic range and contrast based on multiple readout and the excitation light distribution image.

    DOI: 10.11485/itetr.33.23.0_33

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  • CMOS技術による新しい埋め込み型バイオメディカルデバイス

    徳田崇, 笹川清隆, 野田俊彦, 太田淳

    Molecular electronics and bioelectronics   20 ( 2 )   121 - 124   2009.5

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  • 複数回読み出しによるin‐vivo用CMOSイメージセンサの高ダイナミックレンジ化

    笹川清隆, 樋口彩沙子, 田川礼人, 杉山哲也, 南裕樹, 徳田崇, 畠中由美子, 田村英紀, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集   56th ( 3 )   1339   2009.3

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  • ウサギ動物実験に対応した受光機能搭載人工視覚デバイスの開発と機能実証

    竹内陽一, 樋山浩平, 澤村茂樹, 笹川清隆, 徳田崇, 寺澤靖雄, 西田健太郎, 北口義之, 不二門尚, 田野保雄, 太田淳

    応用物理学関係連合講演会講演予稿集   56th ( 3 )   1340   2009.3

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  • ライトガイドアレイ搭載によるin vivo脳神経イメージセンサの高解像度化

    三谷昌弘, 南裕樹, 杉山哲也, 樋口彩沙子, 田川礼人, 笹川清隆, 徳田崇, 田村英紀, 畠中由美子, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集   56th ( 3 )   1339   2009.3

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  • Performance evaluation of pulse-width-modulation image sensor using MOS capacitor

    Sawamura Shigeki, Kagawa Keiichiro, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   33 ( 18 )   21 - 24   2009.3

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    In this report, we discuss a CMOS image sensor that can be integrated with various functional circuits, and achieve a low voltage operation and good image quality. In conventional CMOS image sensors, it is difficult to operate at low voltages to lower the power consumption without deterioration of the performance such as dynamic range. Therefore, we have studied pulse width modulation methods on CMOS image sensors, in which the photodiode voltage is convert to the pulse width by applying a lamp signal to the photodiode through an MOS capacitor. A source-common amplifier is used as an in-pixel comparator. We have evaluated basic characteristics of the prototype chip fabricated in a 0.35-μm CMOS technology.

    DOI: 10.11485/itetr.33.18.0_21

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  • 電界カメラに向けた差動検出イメージセンサの設計

    藤原正英, 笹川清隆, 徳田崇, 太田淳, 土屋昌弘

    電子情報通信学会大会講演論文集   2009 ( 1 )   299 - 299   2009.3

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  • Towards Clinical Application of a Visual Prosthesis

    田野保雄, 瓶井資弘, 生野恭司, 辻川元一, 坂口裕和, 西田健太郎, 方肖雲, 杜兆江, 謝平, 不二門尚, 日下俊次, 森本壮, 中内一揚, 別所建一郎, 下條裕史, 大川賀孝, 北口善之, 福田淳, 澤井元, 三好智満, 八木哲也, 小山内実, 宋文杰, 三宅養三, 近藤峰生, 子安俊行, 坂井隆夫, 栗本幸英, 平形明人, 大路正人, QUIROZ‐MERCADO Hugo, USTARIZ‐GONZALEZ Orlando, CECILIA‐GONZALEZ Carmen, 太田淳, 徳田崇, 小澤素生, 古野間邦彦, 鐘堂健三, 大澤孝治, 中谷正義

    日本眼科学会雑誌   113 ( 3 )   315 - 343   2009.3

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  • Development of Image Sensors for in vivo Brain Imaging on Freely-Moving Mouse

    田川礼人, 樋口彩沙子, 南裕樹, 笹川清隆, 徳田崇, 畠中由美子, 田村英紀, 塩坂貞夫, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-09 ( 1-7 )   17 - 20   2009.2

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  • CMOS based Retinal Prostheis Technology

    TOKUDA Takashi, OHTA Jun

    Proc Int Disp Workshops   16th ( Vol.3 )   2115 - 2118   2009

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  • 11-7 Development of a Multimodal CMOS Image Sensor For in vivo Brain Monitoring

    NODA Toshihiko, SHIOSAKA Sadao, OHTA Jun, TAGAWA Ayato, MINAMI Hiroki, MITANI Masahiro, SASAGAWA Kiyotaka, TOKUDA Takashi, TAMURA Hideki, HATANAKA Yumiko, ISHIKAWA Yasuyuki

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2009 ( 0 )   _11 - 7-1_-_11-7-2_   2009

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    A multimodal CMOS sensor device for in vivo observation of a mouse brain was developed successfully. The CMOS sensor includes an image sensor, electrodes, and a LED as a an excitation light source of fluorescence. Measured results show that the device can simultaneously detect fluorescence and electrical potential associated with neural activities.

    DOI: 10.11485/iteac.2009.0__11-7-1_

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  • Polarization-analyzing image sensor for μTAS based on standard CMOS technology Reviewed

    Jun Ohta, Tokuda, T., Yamada, H., Sasagawa, K., Ohta, J.

    IEEJ Transactions on Sensors and Micromachines   129 ( 8 )   234 - 241   2009

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    DOI: 10.1541/ieejsmas.129.234

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  • Sub-retinal implant device with signal processing function

    YAGYU Keisuke, SASAGAWA Kiyotaka, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun

    ITE Technical Report   32 ( 57 )   5 - 8   2008.12

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    We are developing an retinal prosthesis device using electric stimulation on retinal tissue. In this work, we propose a retinal prosthesis device with signal processing. We designed and characterized circuits for retinal prosthesis in 0.35-μm standard CMOS process.

    DOI: 10.11485/itetr.32.57.0_5

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  • Development of Electrochemical CMOS chip for Artificial Synapse Device

    Minakawa Kyosuke, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    ITE Technical Report   32 ( 50 )   17 - 20   2008.11

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    A bio-implant device which is capable of releasing chemical compounds in small volume for synaptic stimulation, "artificial synapse" would be a powerful tool for clinical therapeutics and biological research. Especially, we are developing a CMOS based, intelligent artificial synapse which can analyze biochemical phenomena by potential sensing, pH sensing etc. In this work, we develop an electrochemical CMOS chip for micro fluid transportation and integrate them on a multifunctional CMOS sensor chip.

    DOI: 10.11485/itetr.32.50.0_17

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  • A retinal prosthesis platform for a subretinal implantation

    YAGYU Keisuke, SASAGAWA Kiyotaka, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun

    ITE Technical Report   32 ( 45 )   131 - 135   2008.10

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    We are developing an artificial vision device to restore vision for the blind by electrically stimulating retinal tissue. We propose a retinal prosthesis that includes artificial vision devices with functions of signal processing, optical detection and electrical stimulation. In the proposed retinal prosthesis, an optical signal is processed and converted to a stimulus current suitable for restoring vision by an arithmetic circuit in the device. In this paper, we describe the functions of proposed retinal prosthesis. In addition, we designed and characterized TEG (Test Element Group) circuits, which are the core blocks and PFM (Pulse Frequency Modulation) photo sensor in standard 0.35-μm CMOS process.

    DOI: 10.11485/itetr.32.45.0_131

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  • A source-modulated pulse-width-modulation CMOS imager for biomedical applications

    SHISHIDO Sanahiro, SASAGAWA Kiyotaka, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun

    ITE Technical Report   32 ( 45 )   73 - 75   2008.10

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    Our goal of research is to achieve a low voltage and low power consumption CMOS image sensor for biomedical applications. We develop the image sensor using pulse-width-modulation scheme that converts voltage change at the photodiode to the pulse width by use of an in-pixel gate-common amplifier. In the previous work we have successfully demonstrated the operation of the PWM sensor with 128^H×96^V pixels under 1.35-V single supply voltage. In this report, we describe some design considerations and formulated about IR drop effect of the PWM sensor. We have designed and fabricated a a CIF (368^H×320^V pixels) size CMOS image sensor with low-voltage low-power-consumption using the PWM pixel readout scheme under 1.2-V single-power-supply voltage.

    DOI: 10.11485/itetr.32.45.0_73

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  • A source-modulated pulse-width-modulation CMOS imager for biomedical applications

    宍戸三四郎, 笹川清隆, 香川景一郎, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   108 ( 253(ICD2008 59-87) )   73 - 75   2008.10

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    Our goal of research is to achieve a low voltage and low power consumption CMOS image sensor for biomedical applications. We develop the image sensor using pulse-width-modulation scheme that converts voltage change at the photodiode to the pulse width by use of an in-pixel gate-common amplifier. In the previous work we have successfully demonstrated the operation of the PWM sensor with 128^H×96^V pixels under 1.35-V single supply voltage. In this report, we describe some design considerations and formulated about IR drop effect of the PWM sensor. We have designed and fabricated a a CIF (368^H×320^V pixels) size CMOS image sensor with low-voltage low-power-consumption using the PWM pixel readout scheme under 1.2-V single-power-supply voltage.

    DOI: 10.11485/itetr.32.45.0_73

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  • A retinal prosthesis platform for a subretinal implantation

    柳生啓佑, 笹川清隆, 香川景一郎, 徳田崇, 太田淳

    電子情報通信学会技術研究報告   108 ( 253(ICD2008 59-87) )   131 - 135   2008.10

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    We are developing an artificial vision device to restore vision for the blind by electrically stimulating retinal tissue. We propose a retinal prosthesis that includes artificial vision devices with functions of signal processing, optical detection and electrical stimulation. In the proposed retinal prosthesis, an optical signal is processed and converted to a stimulus current suitable for restoring vision by an arithmetic circuit in the device. In this paper, we describe the functions of proposed retinal prosthesis. In addition, we designed and characterized TEG (Test Element Group) circuits, which are the core blocks and PFM (Pulse Frequency Modulation) photo sensor in standard 0.35-μm CMOS process.

    DOI: 10.11485/itetr.32.45.0_131

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  • 不可視情報のイメージング最前線 偏光検出CMOSイメージセンサ

    太田淳, 徳田崇

    Optronics   27 ( 322 )   153 - 159   2008.10

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  • 自由行動マウス脳内イメージングのためのCMOSイメージセンサの開発

    樋田彩沙子, 杉山哲也, 田川礼人, 笹川清隆, 徳田崇, 田村英紀, 畠中由美子, 塩坂貞夫, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1154   2008.9

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  • 網膜下埋込みに対応した受光機能搭載人工視覚デバイスの開発

    樋山浩平, 澤村茂樹, 笹川清隆, 徳田崇, 寺澤靖雄, 西田健太郎, 北口義之, 不二門尚, 田野保雄, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1153   2008.9

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  • イメージセンサ型偏光分析CMOSセンサ搭載マイクロチャネルデバイス

    皆川亨介, 山田博文, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1154   2008.9

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  • 多点刺激対応分散型人工視覚デバイスの開発

    澤村茂樹, 笹川清隆, 徳田崇, 寺沢靖雄, 田野保雄, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1153   2008.9

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  • マイクロケミストリに向けたイメージセンサ型偏光分析CMOSセンサ

    山田博文, 笹川清隆, 徳田崇, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1153   2008.9

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  • ライトガイドアレイ搭載高解像度in vivo脳神経イメージセンサ

    杉山哲也, 樋口彩沙子, 田川礼人, 笹川清隆, 徳田崇, 田村英紀, 畠中由美子, 塩坂貞夫, 太田淳

    応用物理学会学術講演会講演予稿集   69th ( 3 )   1154   2008.9

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  • 偏光分析CMOSセンサとそのマイクロケミストリへの応用

    山田博文, 笹川清隆, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2008   ROMBUNNO.11-11   2008.8

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  • 自由行動マウスの脳機能観察用CMOSイメージセンサ―長期埋稙中の撮像安定化に向けた取組み―

    田川礼人, 樋口彩沙子, 杉山哲也, 笹川清隆, 徳田崇, 田村英紀, 塩坂貞夫, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2008   ROMBUNNO.ROMBUNNO.11-10   2008.8

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  • バイオメディカル応用を目指したソース変調型パルス幅変調方式イメージセンサにおける低消費電力化の検討

    宍戸三四郎, 香川景一郎, 徳田崇, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2008   ROMBUNNO.11-9   2008.8

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  • CMOS技術によるバイオメディカルフォトニックデバイス(低電圧/低消費電力技術,新デバイス・回路とその応用)

    徳田崇, 太田淳

    電子情報通信学会技術研究報告. ICD, 集積回路   108 ( 140 )   83 - 88   2008.7

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    CMOS集積回路を用いたバイオメディカルフォトニックデバイス、特に埋め込みでの応用を目指した取り組みについて紹介し、現在の技術課題について解説する。(1)分散型アーキテクチャによる人工視覚向けフレキシブル網膜刺激デバイスおよび(2)in vivo脳神経イメージングセンサについて、チップデザイン、パッケージング、動物実験による動作実証について述べる。

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  • Microchamber device equipped with CMOS image sensor for polarization analysis

    皆川亨介, 山田博文, 徳田崇, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-08 ( 6-15 )   13 - 16   2008.6

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  • 人工視覚用分散型フレキシブル電気刺激デバイスへの受光機能の搭載

    澤村茂樹, 浅野良介, 樋山浩平, 徳田崇, 寺沢靖雄, 布下正宏, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1359   2008.3

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  • 人工視覚向けLSI分散型フレキシブルマルチフィンガー網膜刺激デバイスの開発

    樋山浩平, 浅野良介, 徳田崇, 寺澤靖雄, 布下正宏, 西田健太郎, 北口義之, 中内一揚, 不二門尚, 田野保雄, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1359   2008.3

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  • CMOSイメージセンサを用いたマウス脳内GFP発現のin vivo蛍光イメージング

    樋口彩沙子, 水野太郎, 杉山哲也, NG D.C, 徳田崇, 布下正宏, 田村英紀, 石川保幸, 畠中由美子, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1358   2008.3

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  • MicroTAS向け偏光CMOSセンサによる旋光度計測

    山田博文, 佐藤翔, 徳田崇, 布下正宏, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1357   2008.3

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  • 高解像度in vivo脳神経イメージセンサに向けたライトガイドアレイ構造の作製

    杉山哲也, 樋口彩沙子, 水野太郎, NG D.C, 徳田崇, 布下正宏, 田村英紀, 石川保幸, 畠中由美子, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1358   2008.3

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  • マルチファンクショナルCMOSセンサ搭載マイクロチャンバデバイスの作製

    皆川亨介, 佐藤翔, 徳田崇, 布下正宏, 太田淳

    応用物理学関係連合講演会講演予稿集   55th ( 3 )   1358   2008.3

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  • 生体内埋込型CMOSデバイス

    太田淳, 徳田崇

    電気学会全国大会講演論文集   2008 ( 3 )   3.S24(7)-3.S24(10)   2008.3

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  • 11-9 A power consumption reduction of source-modulated pulse-width-modulation CMOS imager for biomedical applications

    SHISHIDO Sanshiro, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2008 ( 0 )   _11 - 9-1_-_11-9-2_   2008

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    We have designed and fabricated a low-voltage low-power-consumption CIF (352^H×288^V pixels) size CMOS image sensor using PWM pixel readout scheme with a 1.2-V single-power-supply voltage. We also described some design considerations and formulated about IR drop in PWM sensor.

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  • ウサギ動物実験によるCMOS LSI搭載フレキシブル網膜刺激デバイスの機能実証

    徳田崇, 浅野良介, 樋山浩平, 寺澤靖雄, 中内一揚, 西田健太郎, 北口善之, 不二門尚, 田野保雄, 太田淳

    日本生体医工学会大会プログラム・論文集(CD-ROM)   47th   ROMBUNNO.PS2-6-12   2008

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  • 11-11 Polarization-analyzing CMOS sensor and its application to microchemistry

    Yamada Hirofumi, Sasagawa Kiyotaka, Tokuda Takashi, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2008 ( 0 )   _11 - 11-1_-_11-11-2_   2008

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    We propose a polarization analyzing CMOS sensor for microchemistry. In this work, to realize real-time measurement of the optical purity in a microfluidic system, we develop polarization analyzing CMOS sensor with an embedded metal grid polarizer on photodiode array. We examined a highly accurate measurement of optical rotation measurement with the sensor. A new polarization image sensor for high speed measurements was also demonstrated.

    DOI: 10.11485/iteac.2008.0__11-11-1_

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  • 人工視覚デバイス

    太田淳, 徳田崇, 寺澤靖雄, 田野保雄

    日本生体医工学会大会プログラム・論文集(CD-ROM)   47th   ROMBUNNO.S-4-5   2008

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  • 脳内埋込型デバイス

    太田淳, 徳田崇

    日本生体医工学会大会プログラム・論文集(CD-ROM)   47th   ROMBUNNO.OS-16-3   2008

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  • 11-10 A CMOS image sensor for brain functional imaging in a freely-moving mouse : An approach for stable imaging under long-term implant

    Tagawa Ayato, Higuchi Asako, Sugiyama Tetsuya, Sasagawa Kiyotaka, Tokuda Takashi, Tamura Hideki, Shiosaka Sadao, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2008 ( 0 )   _11 - 10-1_-_11-10-2_   2008

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    We have performed a preliminary freely-moving experiment with a CMOS image sensor. Based on the result, we designed a thin and long outlined one to observe a deeper region with a less invasion to the mouse's brain.

    DOI: 10.11485/iteac.2008.0__11-10-1_

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  • Development of CMOS image sensor for visualizing nervous activity in the mouse hippocampus

    樋口彩沙子, 杉山哲也, 水野太郎, NG David C, 徳田崇, 布下正宏, 田村英紀, 塩坂貞夫, 太田淳

    映像情報メディア学会技術報告   31 ( 60(IST2007 100-113) )   29 - 32   2007.12

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  • preliminary analysis of CMOS image sensor for polarization imaging

    佐藤翔, 徳田崇, 香川景一郎, 布下正宏, 太田淳

    映像情報メディア学会技術報告   31 ( 53(IST2007 94-99) )   19 - 22   2007.11

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  • Development of a CMOS-based Neural Imaging and Interface Device

    NG David C, MIZUNO Taro, TOKUDA Takashi, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    映像情報メディア学会技術報告   31 ( 50(IST2007 86-93) )   19 - 22   2007.10

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  • CMOS LSI技術による埋め込み型生体センシング・インターフェース

    徳田崇, NG David C, 浅野良介, 水野太郎, 布下正宏, 太田淳

    電気学会バイオ・マイクロシステム研究会資料   BMS-07 ( 32-37 )   23 - 26   2007.9

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  • CMOS Optical Polarization Analyzer Chip for μTAS

    TOKUDA Takashi, SATO Sho, NUNOSHITA Masahiro, OHTA Jun

    2007   962 - 963   2007.9

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  • Development of a multi-chip retinal stimulator for in vivo experiments toward retinal prosthesis

    TOKUDA Takashi, ASANO Ryosuke, TERASAWA Yasuo, NUNOSHITA Masahiro, NAKAUCHI Kazuaki, FUJIKADO Takashi, TANO Yasuo, OHTA Jun

    2007   974 - 975   2007.9

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  • in vivo脳神経イメージング用CMOSイメージングデバイスの高機能化

    徳田崇, 水野太郎, NG David C, 布下正宏, 田村英紀, 塩坂貞夫, 太田淳

    電気学会電子・情報・システム部門大会講演論文集(CD-ROM)   2007   TC8-7   2007.9

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  • ウサギ動物実験によるLSI分散型フレキシブル網膜刺激デバイスの機能実証

    浅野良介, 徳田崇, 香川景一郎, 布下正宏, 寺澤靖雄, 中内一揚, 不二門尚, 田野保雄, 太田淳

    応用物理学会学術講演会講演予稿集   68th ( 3 )   1308   2007.9

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  • MicroTAS向け光・電気化学CMOSマイクロセンサ“Chemo‐Photonic LSI”の提案

    佐藤翔, 徳田崇, 香川景一郎, 布下正宏, 太田淳

    応用物理学会学術講演会講演予稿集   68th ( 3 )   1309   2007.9

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  • 電極・光源内蔵CMOSイメージングデバイスによるin vivo脳神経イメージング

    水野太郎, NG D. C, 徳田崇, 香川景一郎, 布下正宏, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学会学術講演会講演予稿集   68th ( 3 )   1309   2007.9

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  • in vivo脳神経イメージング用CMOSイメージングデバイスへの光源内蔵と低侵襲化

    水野太郎, 中川琢磨, C.NG David, 徳田崇, 香川景一郎, 布下正宏, 田村英紀, 塩坂貞夫, 太田淳

    映像情報メディア学会年次大会講演予稿集(CD-ROM)   2007   ROMBUNNO.13-7   2007.8

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  • CMOS LSIを用いた人工視覚向けフレキシブル網膜刺激デバイスの開発

    浅野良介, 杉谷幸愛, 徳田崇, 香川景一郎, 布下正宏, 太田淳, 上原昭宏, 寺澤靖雄, 中内一揚, 不二門尚, 田野保雄

    電気学会バイオ・マイクロシステム研究会資料   BMS-07 ( 7-31 )   29 - 32   2007.7

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  • Combining MEMS and CMOS Technologies in the Development of a Highly-Integrated Neural Imaging and Interface Device

    NG David C, MIZUNO Taro, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    映像情報メディア学会技術報告   31 ( 28(IST2007 31-45/ME2007 94-108) )   9 - 12   2007.6

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  • CMOSイメージセンサ技術をベースとしたバイオセンシング・バイオインターフェースチップ

    徳田崇, NGDavid, 布下正宏, 太田淳

    Molecular electronics and bioelectronics   18 ( 2 )   139 - 142   2007.6

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  • in vivo脳神経イメージング用CMOSイメージングデバイスの高機能実装

    水野太郎, 中川琢磨, NG David C, 徳田崇, 香川景一郎, 布下正宏, 田村英紀, 石川保幸, 塩坂貞夫, 太田淳

    応用物理学関係連合講演会講演予稿集   54th ( 3 )   1374   2007.3

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  • 動物実験に向けたLSI分散型フレキシブル網膜刺激デバイスの開発

    浅野良介, 杉谷幸愛, 上原昭宏, 寺澤靖雄, 徳田崇, 香川景一郎, 布下正宏, 中内一揚, 不二門尚, 田野保雄, 太田淳

    応用物理学関係連合講演会講演予稿集   54th ( 3 )   1375   2007.3

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  • 光・電位デュアルイメージCMOSセンサによるDNAの電位イメージング

    佐藤翔, 角脇一誠, 徳田崇, 香川景一郎, 布下正宏, 太田淳

    応用物理学関係連合講演会講演予稿集   54th ( 3 )   1374   2007.3

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  • Detection of on-chip DNA spots using an optical/potential dual-image CMOS sensor

    徳田崇, 角脇一誠, 香川景一郎, 布下正宏, 太田淳

    映像情報メディア学会技術報告   31 ( 3(IST2007 1-14) )   25 - 28   2007.1

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  • Implantable CMOS Image Sensor with Integrated Light Source for Functional Neural Imaging

    NG David C, NAKAGAWA Takuma, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    映像情報メディア学会技術報告   31 ( 3(IST2007 1-14) )   29 - 32   2007.1

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  • A CMOS LSI-based flexible retinal stimulator for retinal prosthesis Reviewed

    Jun Ohta, Tokuda, T., Sugitani, S., Asano, R., Taniyama, M., Terasawa, Y., Uehara, A., Kagawa, K., Nunoshita, M., Tano, Y., Ohta, J.

    IEEJ Transactions on Electronics, Information and Systems   127 ( 10 )   1588 - 1594   2007

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    DOI: 10.1541/ieejeiss.127.1588

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  • Development of a fully integrated complementary metal-oxide-semiconductor image sensor-based device for real-time in vivo fluorescence imaging inside the mouse hippocampus Reviewed

    Jun Ohta, Ng, D.C., Nakagawa, T., Tokuda, T., Nunoshita, M., Tamura, H., Ishikawa, Y., Shiosaka, S., Ohta, J.

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers   46 ( 4 B )   2811 - 2819   2007

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  • A multi-microchip retinal stimulator for in vitro/in vivo experiments

    OHTA Jun, TOKUDA Takashi, KAGAWA Keiichiro, UEHARA Akihiro, TERASAWA Yasuo, NAKAUCHI Kazuki, FUJIKADO Takashi, TANO Yasuo

    IEEE Int Symp Circuits Syst   2007 Vol.6   2024 - 2027   2007

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  • 13-7 Less-invasive CMOS image sensor module with embedded light source for in vivo brain imaging

    Mizuno T, Nakagawa T, Ng. D. C, Tokuda T, Kagawa K, Nunoshita M, Tamura H, Shiosaka S, Ohta J

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2007 ( 0 )   _13 - 7-1_   2007

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    We are developing an implantable CMOS image sensor module for in vivo fluorescence imaging of mouse brain. We successfully developed an imaging device for in vivo experiments with less-invasive outline, evenly embedded excitation light source and improved biocompatibility.

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  • Integration of CMOS and MEMS technologies in the development of a neural imaging and interface device: Showcase of an emerging bioimaging technique

    Ng, David C., Mizuno, Taro, Tokuda, Takashi, Nunoshita, Masahiro, Tamura, Hideki, Ishikawa, Yasuyuki, Shiosaka, Sadao, Ohta, Jun, IEEE

    Proceedings of the Ieee 2007 Custom Integrated Circuits Conference   2007 Vol.2   837 - 840   2007

  • A flexible neural stimulator for retinal prosthesis based on CMOS LSI technology

    TOKUDA T, SUGITANI S, TANIYAMA M, UEHARA A, TERASAWA Y, KAGAWA K, NUNOSHITA M, OHTA J

    電気学会研究会資料. MBE, 医用・生体工学研究会   2006 ( 51 )   53 - 56   2006.11

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  • in vivo fluorescence imaging of enzyme expression in the brain using an implantable CMOS image sensor device

    NAKAGAWA Takuma, NG David C, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    ITE technical report   30 ( 59 )   9 - 12   2006.11

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  • An optical/potential dual-image CMOS sensor for DNA analysis

    KADOWAKI Issei, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSITA Masahiro, OHTA Jun

    ITE technical report   30 ( 59 )   17 - 20   2006.11

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  • Multi-chip LSI-based neural stimulation device for retinal prosthesis

    TANIYAMA Mari, SUGITANI Sachie, UEHARA Akihiro, TERASAWA Yasuo, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, OHTA Jun

    ITE technical report   30 ( 59 )   1 - 4   2006.11

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  • Implantable Bioimaging Sensors

    NG David C, NAKAGAWA Takuma, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro, OHTA Jun

    映像情報メディア学会技術報告   30 ( 54(IST2006 57-62) )   9 - 12   2006.10

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  • Development of a CMOS Image Sensor for Real Time In Vivo Imaging of the Protease Activity Inside the Mouse Hippocampus

    NG David C., NAKAGAWA Takuma, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    2006   892 - 893   2006.9

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  • An Optical/Potential/Voltammetric Multifunctional CMOS Image Sensor for On-chip Biomolecular/Neural Sensing Applications

    TOKUDA T., KADOWAKI I., KAGAWA K., NUNOSHITA M., OHTA J.

    2006   894 - 895   2006.9

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  • Large scale electrode array based on distributed microchip architecture for retinal prosthesis

    OHTA Jun, TOKUDA Takashi, SUGITANI Sachie, TANIYAMA Mari, NUNOSHITA Masahiro, UEHARA Akihiro, TERASAWA Yasuo, TANO Yasuo

    2006   896 - 897   2006.9

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  • Digital vision chip architecture for retinal prosthesis and preliminary experiments

    KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro, OHTA Jun

    ITE technical report   30 ( 38 )   41 - 46   2006.7

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  • Digital vision chip architecture for retinal prosthesis and preliminary experiments

    KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro, OHTA Jun

    IEICE technical report   106 ( 189 )   41 - 46   2006.7

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    We are studying vision chips for retinal prosthesis in which the vision chip implanted on or underneath the retina of the blind patients makes visual sensation by stimulating the surviving retinal cells according to the captured images. In this report, we describe a distributed and isolated microchip architecture powered by infrared light to cover large area of the retina with multiple microchips to decrease operation faults concerning disconnection of electric contacts or damages to the packaging. We also discuss digital implementation of almost all part of the pixel circuits of the vision chip to make design and verification easy. By use of a pulse-frequency-modulation photosensor with wide dynamic range using a capacitive-feedback-reset scheme that works as a 1-bit ADC, the vision chip architecture with synthesizability from HDL sources was discussed. We also show a real-time emulator to verify operation of image processing circuits described by HDL.

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  • Low-Voltage Vision Chip Using a Pulse Frequency Modulation Scheme for Retinal Prosthesis Device

    KAGAWA Keiichiro, YAMAMOTO Shinya, FURUMIYA Tetsuo, TOKUDA Takashi, NUNOSHITA Masahiro, OHTA Jun

    IEICE technical report   105 ( 606 )   53 - 58   2006.2

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    We report a low-voltage digital vision chip based on a pulse-frequency-modulation (PFM) photosensor using capacitive feedback reset and pulse-domain digital image processing to explore its feasibility of low power consumption and high dynamic range even at a low power-supply voltage. An example of the applications of the vision chip is retinal prosthesis, in which supplied power is limited. The pixel is composed of a PFM photosensor, which converts intensity of the incident light to the frequency of digital pulses, with a dynamic pulse memory, and a 1-bit digital image processor. The image processor executes spatial filtering by mutual operations between the pulses from the pixel and those from the four neighboring pixels. The weights in image processing are controlled by pulse gates situated before the image processor. We fabricated a test chip of the vision chip in a standard 0.35-μm CMOS technology. Pixel size and pixel counts were 100μm sq. and 32×32, respectively. In the experiments, four neighboring pixels were considered in image processing. The test chip successfully operated at low power supply voltage around 1.25 V. The frame rate was 26 kfps. Low-pass filtering, edge enhancement, and edge detection have been demonstrated. Relationships between power supply voltages and characteristics of the vision chip are investigated.

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  • Toward 1000-ch electrode array based on distributed microchip architecture for retinal prosthesis

    OHTA Jun, TOKUDA Takashi, KAGAWA Keiichiro, UEHARA Akihiro, TERASAWA Yasuo, SHODO Kenzo, FUJIKADO Takashi, TANO Yasuo

    IEEE Int Symp Circuits Syst   2006 Vol.8   4118 - 4122   2006

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  • Implementation of eye-safe imaging capability onto CMOS image sensors with reverse-carrier-injection Reviewed

    Jun Ohta, Tokuda, T., Mori, D., Kagawa, K., Nunoshita, M., Ohta, J.

    Kyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers   60 ( 3 )   366 - 372   2006

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    DOI: 10.3169/itej.60.366

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  • 17-3 In vivo imaging of protease expression using an implantable CMOS image sensor

    Nakagawa T, Ng David C, Tokuda T, Kagawa K, Nunoshita M, Tamura H, Shiosaka S, Ohta J

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2006 ( 0 )   _17 - 3-1_   2006

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    We have developed an implantable CMOS image sensor module for in vivo fluorescence imaging of the mouse brain. By using this device, we have successfully imaged protease expression deep inside the hippocampus of the mouse brain.

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  • Prototyping and evaluation of a 32 × 32-pixel pulse-frequency- modulation vision chip with capacitive feedback reset Reviewed

    Jun Ohta, Yamamoto, S., Kagawa, K., Furumiya, T., Tokuda, T., Nunoshita, M., Ohta, J.

    Kyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers   60 ( 4 )   621 - 626   2006

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    DOI: 10.3169/itej.60.621

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  • An optical and potential dual-image CMOS sensor for on-chip neural and DNA imaging applications

    TOKUDA Takashi, NG David C, YAMAMOTO Akio, KAGAWA Keiichiro, NUNOSHITA Masahiro, OHTA Jun

    IEEE Int Symp Circuits Syst   2006 Vol.3   1127 - 1130   2006

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  • A Multi-Functional CMOS Image Sensor with On-Chip Multi-site Electrochemical Sensing Function

    TANAKA Kunihiro, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, OHTA Jun

    電気学会研究会資料. PHS, フィジカルセンサ研究会   29 ( 67 )   31 - 34   2005.11

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  • 電気化学計測機能を搭載したオンチップバイオセンシング用マルチファンクショナルCMOSイメージセンサ

    田中 邦博, 徳田 崇, 香川 景一郎

    研究会講演予稿   221   31 - 34   2005.11

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  • Optical and potential dual-image CMOS sensor for on-chip DNA micro-array analysis

    YAMAMOTO Akio, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, OHTA Jun

    ITE technical report   29 ( 62 )   1 - 4   2005.10

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  • A CMOS Image Sensor for in vitro and in vivo Imaging of the Mouse Hippocampus

    NG David C., MATSUO Masamichi, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao, OHTA Jun

    2005   74 - 75   2005.9

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  • Pulse modulation CMOS image sensor for bio-fluorescence imaging applications

    OHTA Jun, TOKUDA Takashi, KAGAWA Keiichiro, NUNOSHITA Masahiro, SHIOSAKA Sadao

    IEEE Int Symp Circuits Syst   2005 Vol.4   3487 - 3490   2005

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  • Safety and effectiveness of suprachoroidal-transretinal stimulation by chronically implanted electrode with continuous electrical stimulation in rabbits

    K Nakauchi, T Fujikado, J Ohta, T Tokuda, H Kanda, Y Terasawa, M Ozawa, A Hirakata, Y Tano

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   46   2005

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  • 22-2 Development of a CMOS image sensor for in vivo neural imaging

    Matsuo M, Ng David C, Tokuda T, Kagawa K, Nunoshita M, Ohta J

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2005 ( 0 )   _22 - 2-1_   2005

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    We have designed a CMOS image sensor especially designed for in vivo, on-chip neural imaging. We also developed packaging technique of an in vivo imaging module. In vivo fluorescence imaging of a mouse's hippocampus was successfully performed

    DOI: 10.11485/iteac.2005.0__22-2-1_

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  • 7-1 A Low-Voltage Pulse-Frequency-Modulation Vision Chip with In-Pixel Digital Image Processing Circuits

    Yamamoto Shinya, Furumiya Tetsuo, Kagawa Keiichiro, Tokuda Takashi, Nunoshita Masahiro, Ohta Jun

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2005 ( 0 )   _7 - 1-1_   2005

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    We have been developing a low-voltage Pulse-Frequency-Modulation (PFM)-based vision chip using capacitive-feedback reset and pulse-domain digital image processing. We have fabricated a 12 x 12-pixel PFM vision chip in a standard 0.35-μm CMOS technology. From the experimental results, we have demonstrated 1.2-V operation of several kinds of image processing.

    DOI: 10.11485/iteac.2005.0__7-1-1_

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  • Retinal prosthesis device based on pulse-frequency-modulation vision chip

    OHTA Jun, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    IEEE Int Symp Circuits Syst   2005 Vol.3   2923 - 2926   2005

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  • A CMOS optical/potential image sensor with 7.5.MU.m pixel size for on-chip neural and DNA spot sensing

    TOKUDA Takashi, NG David C, YAMAMOTO Akio, KAGAWA Keiichiro, NUNOSHITA Masahiro, OHTA Jun

    Proc Annu Int Conf IEEE Eng Med Biol Soc   27th ( Vol.7 )   7269 - 7272   2005

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  • A Fabrication of Pulse Frequency Modulation Vision Chip for Retinal Prosthesis, and Functional Verification Using the Detached Frog Retina

    FURUMIYA Tetsuo, YASUOKA Koutaro, NG David C, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun, NUNOSHITA Nasahiro

    IEICE technical report. Neurocomputing   104 ( 474 )   31 - 35   2004.11

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    We are developing the pulse-frequency-modulation (PFM) retinal prosthesis vision chip for the purpose of the visual sensation by electrical stimulus to the retinal cells. We have designed and fabricated a 16x16-pixel PFM vision chip as a retinal prosthesis device. This vision chip is a prototype for demonstrating application in in vitro electrophysiological experiments. Each pixel has a bonding pad on which a stimulus electrode is formed by Pt/Au stacked biocompatible electrode. We have evaluated the vision chip by in vitro electrophysiological experiments using detached frog retina, and confirmed that it can electrically stimulate the retinal cells effectively.

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  • Pulse modulation image sensor for in vitro brain imaging

    TOKUDA Takashi, NG David C, OKAMOTO Hideki, MATSUO Masamichi, YAMAMOTO Akio, KAGAWA Keiichiro, OHTA Jun, NUNOSHITA Masahiro, TAMURA Hideki, SHIOSAKA Sadao

    ITE technical report   28 ( 59 )   17 - 20   2004.10

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  • A four-transistor type photosensor with in-pixel analog-to-digital converter using MOS interface-trap charge pumping

    UEHARA Akihiro, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    ITE technical report   28 ( 58 )   1 - 4   2004.10

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  • Low voltage, low power consumption, and wide-dynamic-range image sensor based on pulse-frequency-modulation

    YASUOKA Koutaro, KAGAWA Keiichro, FURUMIYA Tetsuo, YAMAMOTO Shinya, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    ITE technical report   28 ( 58 )   17 - 20   2004.10

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  • A Pulse Modulation CMOS Image Sensor with 120dB Dynamic Range and 1nW/cm^2 Resolution for Bioimaging Applications

    NG David C., OKAMOTO Hideki, TOKUDA Takashi, KAGAWA Keiichiro, OHTA Jun, NUNOSHITA Masahiro

    2004   384 - 385   2004.9

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  • A Flexible and Extendible Neural Stimulation Device with Distributed Multi-chip Architecture for Retinal Prosthesis

    PAN Yi-Li, TOKUDA Takashi, UEHARA Akihiro, KAGAWA Keiichiro, OHTA Jun, NUNOSHITA Masahiro

    2004   352 - 353   2004.9

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  • 分散センサ・ネットワークによる人工視覚デバイス

    上原昭宏, PANYi-Li, 香川景一郎, 徳田崇, 太田淳, 布下正宏

    映像情報メディア学会技術報告   28 ( 37 )   59 - 64   2004.7

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  • 分散センサ・ネットワークによる人工視覚デバイス(アナログ・ディジアナ・センサ,通信用LSI)

    上原昭宏, PanYi-Li, 香川景一郎, 徳田崇, 太田淳, 布下正宏

    電子情報通信学会技術研究報告. ICD, 集積回路   104 ( 174 )   59 - 64   2004.7

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    我々は,網膜組織の電気刺激による視覚再生を目的として,体内撮像型人工視覚デバイスの開発をおこなっている.鮮明な視覚再生には,多くの刺激電極が必要だが,従来の人工視覚デバイスでは,刺激電極数が基板配線密度で制限される問題があった.この論文で提案する分散センサ・ネットワークを用いた体内撮像型人工視覚デバイスは,マイクロサイズのCMOSデバイスを基板に分散配置し,シリアル・バスで個々のデバイスをネットワーク接続したもので,基板配線密度に制限されることなく,刺激点数が多く,かつ網膜曲面に沿って曲がる柔軟な刺激電極アレイを実現できる.0.6-μm CMOSプロセスで試作したデバイスは,大きさ500μm×500μm,消費電力12μW,画素レベルADC画素回路のダイナミックレンジは60dB以上で,撮像動作および電気刺激動作を確認した.

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  • High photosensitivity pulse modulation image sensor for bioimaging applications

    TOKUDA Takashi, NG David C, OKAMOTO Hideki, KAGAWA Keiichiro, OHTA Jun, NUNOSHITA Masahiro

    ITE technical report   28 ( 23 )   15 - 18   2004.3

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  • 32×32 Pixel Pulse-frequency-modulation Based Image Sensor for Retinal Prosthesis

    FURUMIYA Tetsuo, KAGAWA Keiichiro, UEHARA Akihiro, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    The Journal of the Institute of Television Engineers of Japan   58 ( 3 )   352 - 361   2004.3

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    We demonstrated a CMOS image sensor using pulse frequency modulation (PFM) for retinal prosthesis. We are fabricated the 32x32 pixel PFM image sensor with standard 0.6μm CMOS technology. We designed this chip for use in in vitro electro-physiology experiments. The image sensor pixel was composed of a PFM-based photosensor with a frequency limiter, a pulse shaper/amplifier, and a stimulus electrode. We measured the image sensor response vs. the illumination level. We further verified the pulse shaper/amplifier characteristics. By using the current output from the stimulus electrode, we successfully demonstrated positive and negative current output of 100μA driving an external electrode placed inside a multi-electrode array immersed in saline. This result shows that this chip could be used in vitro electro-physiology experiments. To observe the output pulse from the sensor, we used the LED display in order to visualize the input scene from each pixel output pulses, and demon-strates the visualization successfully.

    DOI: 10.3169/itej.58.352

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  • 20-7 Photosensitivity spectrum of trans-chip eye-safe image sensor fabricated by bottom-side wafer bonding

    Mori Daisuke, Tokuda Takashi, Kagawa Keiichiro, Ohta Jun, Nuoshita Masahiro

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2004 ( 0 )   _20 - 7-1_   2004

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    We have been developing an image sensor which is capable to detect IR in eye-safe region. In this work, we demonstrate that eye-safe light can be efficiently detected with a sensor structure that consists of metal-bonded Si image sensor chip and Ge subwafer.

    DOI: 10.11485/iteac.2004.0__20-7-1_

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  • 20-6 Photosensitivity of pulse modulation image sensor for bioimaging and biosensing applications

    Tokuda Takashi, Ng David C, Okamoto Hideki, Kagawa Keiichiro, Ohta Jun, Nunoshita Masahiro

    PROCEEDINGS OF THE ITE ANNUAL CONVENTION   2004 ( 0 )   _20 - 6-1_-_20-6-2_   2004

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    Image sensors working with pulse modulation measuring scheme are proposed for applications of bioimaging and biosensing. A dynamic range of 120dB and a minimum sensing intensity level of 20nW/cm^2 were obtained. It is also confirmed that 5% of intensity change is detectable at the minimum intensity region.

    DOI: 10.11485/iteac.2004.0__20-6-1_

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  • Observation of SiGe/Si micro-origami structure fabricated on SOI substrate

    SAKANO Yoshihisa, MORI Daisuke, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro, KUBOTA Kazuyoshi, VACCARO Pablo O, TAMURA Syuichi, WANG Hailong, SAITO Nobuo

    Technical report of IEICE. SDM   103 ( 533 )   57 - 61   2003.12

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    A "micro-origami" structure was fabricated with SiGe/Si heteroepitaxial layers grown on a SOI substrate. As a sacrificial layer in the micro-origami process, the BOX layer of a SOI substrate was etched in the process. The fabrication of microtubes, and a hinge & plate structure were successfully demonstrated. The strain in the epitaxial structures in micro-origami was characterized by a laser raman spectroscopy.

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  • A Vision Chip for Retinal Prosthesis with Pulse-Domain Image Preprocessing

    OHTA Jun, FURUMIYA Tesuto, NG David C, UEHARA Akihiro, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    電子情報通信学会技術研究報告. NC, ニューロコンピューティング   103 ( 466 )   19 - 23   2003.11

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    We have fabricated and demonstrated vision chips to be implanted in a subretinal space for retinal prosthesis. The chips are based on a pulse frequency modulation and modified to stimulate retinal cell more effectively. The maximum frequency and biphasic current pulse are realized in 32×32-pixel vision chip. Another chip is implemented an image preprocessing functions for low resolution. Based on a frequency domain image processing, we have designed a 16×16-pixel vision chip for retinal prosthesis.

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  • Pulsed Frequency Modulation-based Retinal Implant Chip with 1-bit Pulse Image Processing

    NG David C, FURUMIYA Tetsuo, UEHARA Akihiro, KAGAWA Keiichiro, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    ITE technical report   27 ( 58 )   9 - 12   2003.10

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  • A concept of an image sensor with a bonded Ge Wafer on backside for trans-chip Eye-safe detection

    TOKUDA Takashi, MORI Daisuke, KAGAWA Keiichiro, OHTA Jun, MUNOSHITA Masahiro

    ITE technical report   27 ( 58 )   29 - 32   2003.10

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  • Extension of NIR detection capability for image sensors using SiGe layer

    TOKUDA Takashi, HAYASHI Tetsuya, SAKANO Yoshihisa, KAGAWA Keiichiro, OHTA Jun, NUNOSHITA Masahiro

    ITE technical report   27 ( 26 )   19 - 22   2003.4

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  • Image acquisition by a 32x32-pixel retinal-prosthesis image sensor for in vitro experiments and investigation of digital image processing specialized to pulse frequency modulation photosensors

    Kagawa Keiichiro, Furumiya Tetsuo, Isakari Keiichi, Uehara Akihiro, Tokuda Takashi, Ohta Jun, Nunoshita Masahiro

    ITE Technical Report   27 ( 25 )   5 - 8   2003.3

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    We are developing a pulse-frequency-modulation (PFM) CMOS image sensor for retinal prosthesis based on a subretinal approach. This report describes a 32x32 retinal-prosthesis image sensor for in vitro measurements of responses from ganglion cells in electric stimulation. To control photosensitivity for automatic exposure, we propose two different methods based on frequency division and pulse sampling. We have fabricated a PFM photosensor with an asynchronous counter as a frequency divider in a 0.6μm CMOS technology, and have demonstrated that frequency of original pulses from the PFM photosensor was reduced to 1/1 to 1/128 (less than hundreds of hertz, which is appropriate for effective excitation of retinal neurons). We also propose a new image processing scheme specific to the PFM photosensor by use of merge and disappearance of digital pulses.

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  • Fundamental Study on an Image Sensor Integrated with Light Emitting Diodes Using BiCMOS Fabrication Technology

    OHTA Jun, ISAKARI Keiichi, NAKAYAMA Hirokatsu, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    The Journal of the Institute of Television Engineers of Japan   57 ( 3 )   378 - 383   2003.3

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    We have fabricated and demonstrated fundamental characteristics of an image sensor integrated with Si-LED using standard S1Ge-B1CMOS process technology Two types of LEDs, avalanche and Zener, were fabricated, in terms of breakdown mode The avalanche type LED was found to have better emission efficiency. We also studied the dependence of the distance between LED and APS on the discharge characteristics of the APS and found that over 500 ii m is required to suppress the effect from the LED

    DOI: 10.3169/itej.57.378

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  • An image sensor integrated with light emission diodes using a standard SiGe-BiCMOS fabrication technology

    OHTA Jun, ISAKARI Keiichi, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    ITE Technical Report   26 ( 62 )   59 - 64   2002.9

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    We have fabricated and demonstrated fundamental characteristics of an image sensor integrated with Si-LED using a standard SiGe-BiCMOS process technology. The fabricated LEDs are classified into two types of avalanche and Zener in their breakdown mode. The avalanche type LED has found better emission efficiency. We have studied that the dependence of the distance between LED and APS on the discharge characteristics of the APS and found that over 500 μm is required to sunnress the effert from the LED.

    DOI: 10.11485/itetr.26.62.0_59

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  • An image sensor integrated with light emission diodes using a standard SiGe-BiCMOS fabrication technology

    OHTA Jun, ISAKARI Keiichi, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    Technical report of IEICE. ICD   102 ( 339 )   59 - 64   2002.9

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    We have fabricated and demonstrated fundamental characteristics of an image sensor integrated with Si-LED using a standard SiGe-BiCMOS process technology. The fabricated LEDs are classified into two types of avalanche and Zener in their breakdown mode. The avalanche type LED has found better emission efficiency. We have studied that the dependence of the distance between LED and APS on the discharge characteristics of the APS and found that over 500 μm is required to suppress the effect from the LED.

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  • A Fabrication of an Image Sensor Using SiGe-BiCMOS Technology(Special Issue on Semiconductor Electronics)

    OHTA Jun, TOKIDA Naoyuki, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro

    Journal of the Society of Materials Science, Japan   51 ( 9 )   1005 - 1009   2002.9

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    Language:Japanese   Publisher:社団法人日本材料学会  

    We have demonstrated an image sensor using SiGe BiCMOS fabrication process for detecting object illuminated by light in "eye-safe" band. The fabrication process is general O.8μm 2-poly 2-metal SiGe BiCMOS process for RF application. SiGe-Si photodiodes and Si-SiGe-Si hetero-phototransistors as well as Si homojunction photodiodes and phototransistors have been fabricated and measured. The gain of the hetero-phototransistor was around 100. There was little difference between the sensitivity characteristics of SiGe and Si photodetectors. An image sensor with 32×32 pixels has been fabricated using a phototransistor as a detector, which of the base is made of SiGe layer. The dynamic range was 23dB and the minimum detectable light intensity was 10 lux. We have successfully acquired images by using this image sensor. The future issues to use SiGe BiCMOS process for image sensors are discussed.

    DOI: 10.2472/jsms.51.1005

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  • DIGITAL CMOS IMAGE SENSOR WITH 32×32 PIXELS FOR VISUAL RECOVERY

    Kagawa Keiichiro, Furumiya Tetsuo, Uehara Akihiro, Isakari Keiichi, Ng Dabid, Tokuda Takashi, Ohta Jun, Nunoshita Masahiro

    Proceedings of the Society Conference of IEICE   2002 ( 2 )   83 - 83   2002.8

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  • The effects of low temperature growth and IBAD on C incorporation into GeC epilayers on Si (001) substrates

    OKINAKA M, MIYATAKE K, HAMANA Y, TOKUDA T, OHTA J, NUNOSHITA M

    IEICE technical report. Component parts and materials   102 ( 79 )   55 - 60   2002.5

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    The effects of low temperature growth and ion beam assisted deposition (IBAD) on C incorporation into MBE growth GeC/Si (001) substrates were investigated. By decreasing the growth temperature, substitutional C composition increased and the formation of C clusters was suppressed. By means of IBAD, the Ar^+ ion bombardment at bias voltage V_b=200V induces both increase of substitutional C composition and better crystalline quality. For V_b≥400V the crystalline quality deteriorated. Lower growth temperature and IBAD with an appropriate V_b were effective to increase substitutional C compositionin in GeC epilayers.

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  • Crystallinity and optical properties of Ge_<1-x>C_x on Si(001) and Ge(001)

    OKINAKA Motoki, HAMANA Yasumasa, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    IEICE technical report. Electron devices   101 ( 338 )   7 - 12   2001.10

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    The crystallinity and optical properties of Ge_&lt;1-x&gt;C_x alloys on Si(001) and Ge(001) substrates have been characterized, aiming at the increase of C composition in Ge_&lt;1-x&gt;C_x alloy and the change for direct-bandgap structure. The optimum growth temperature for x=0.03 was 400℃. The possibilities for the increase of C composition by faster growth rate and the control of the strain between the substrate and Ge_&lt;1-x&gt;C_x alloy were shown. From the results of spectroscopic ellipsometry, the aggravation of the crystallinity and an increase of the strength of the E_1 critical point with C composition were observed.

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  • MBE growth of GeC using arc plasma gun for a C molecular beam

    OKINAKA Motoki, DANSHO Ryoichi, HAMANA Yasumasa, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    IEICE technical report. Electron devices   101 ( 79 )   19 - 24   2001.5

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    An arc plasma gun was applied for a new C source in molecular beam epitaxiy (MBE). Basic properties of this C source have been characterized and GeC epilayers on Ge substrates were grown. C layers deposited by the arc plasma gun have few micro-particles which deteriorate device performance. The growth modes of the GeC epilayers were dependent on the C fraction. It is confirmed that most of the supplied C atoms are incorporated in the GeC alloys. Therefore the arc plasma gun is a promising C source for the MBE growth of GeC alloys.

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  • 強誘電体薄膜のナノ構造とそのメゾスコピックな物性 (特集 ナノ・ケモテクノロジーへの招待--奈良先端科学技術大学院大学物質創成科学研究科)

    布下 正宏, 太田 淳, 徳田 崇

    マテリアルインテグレ-ション   14 ( 5 )   29 - 37   2001.5

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  • An image sensor using SiGe BiCMOS process

    Tokida Naoyuki, Tokuda Takashi, Ohta Jun, Nunoshita Masahiro

    ITE Technical Report   25 ( 28 )   13 - 18   2001.3

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    We have demonstrated an image sensor using SiGe BiCMOS fabrication process for detecting object illuminated by light in &quot;eye-safe&quot;band. The process is general SiGe BiCMOS process for RF application. An image sensor with 32x32 pixels have been fabricated using a photo-transistor as a detector, which of the base is SiGe layer. Fundamental device characteristics have been demonstrated.

    DOI: 10.11485/itetr.25.28.0_13

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  • Observation of Ge segregation and Si-Ge intermixing by CAICISS

    TOKUDA Takashi, HATTORI Yasunori, OKINAKA Motoki, OHTA Jun, NUNOSHITA Masahiro

    Technical report of IEICE. SDM   100 ( 517 )   43 - 48   2000.12

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    A novel analyzing method utilizing the shadowing effect in CAICISS(Coaxial impact collision ion scattering spectroscopy)is proposed and applied to characterization of Ge segregation and Si-Ge intermixing at Ge/Si, and SiGe/Si interfaces. It is clarified that information about Ge distribution within 3〜7MLs from the surface is available and confirmed that Ge segregation and Si-Ge intermixing occur even at 300℃ and 500℃, respectively.

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  • 4-4 Fabrication of an image sensor using SiGe BiCMOS process

    Tokida Naoyuki, Tokuda Takashi, Ohta Jun, Nunoshita Masahiro

    PROCEEDINGS OF THE ITE WINTER ANNUAL CONVENTION   2000 ( 2000 )   74 - 74   2000.12

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  • Low voltage operation of vision chips based on pulse frequency modulation technique

    OHTA Jun, SAKATA Hirohiko, HIRAI Takao, TOKUDA Takashi, NUNOSHITA Masahiro

    Technical report of IEICE. ICD   24 ( 53 )   51 - 56   2000.9

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    This paper reports a pixel circuit of a vision chip based on a pulse frequency modulation technique, which is a kind of merged analog and digital techniques. A test chip has been fabricated using a CMOS 0.35μm rule to have a pulse frequency modulation circuits and a photodiode with 2μm square size in a pixel. The chip has been demonstrated that it works under the operation voltage of 0.6V with the dynamic range of over 50dB.

    DOI: 10.11485/itetr.24.53.0_51

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  • Low voltage operation of vision chips based on pulse frequency modulation technique

    OHTA Jun, SAKATA Hirohiko, HIRAI Takao, TOKUDA Takashi, NUNOSHITA Masahiro

    Technical report of IEICE. ICD   100 ( 310 )   51 - 56   2000.9

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    This paper reports a pixel circuit of a vision chip based on a pulse frequency modulation technique, which is a kind of merged analog and digital techniques. A test chip has been fabricated using a CMOS 0.35μm rule to have a pulse frequency modulation circuits and a photodiode with 2μm square size in a pixel. The chip has been demonstrated that it works under the operation voltage of 0.6V with the dynamic range of over 50dB.

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  • A pulse modulated vision chip in eye-safe band

    Uehara Akihiro, Tokida Naoyuki, Tokuda Takashi, Ohta Jun, Nunoshita Masahiro

    ITE Technical Report   24 ( 27 )   23 - 28   2000.3

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    We propose and demonstrate a vision chip that can detect eye-safe light by using SiGe heterobipolar transistor process. This process realizes monolithic integration with an eye-safe heterophototransistor(HPT)and CMOS circuits. The responsivity of the HPT is simulated and is found to have enough sensitivity in the eye-safe region. To employ the HPT in a vision chip, we design a test chip with pulse frequency modulation circuits, which has a wide dynamic range without accumulation action. The chip designed using 0.35μm CMOS 2P3M process works well under a power supply of 0.7V and has a dynamic range of 20dB and a power consumption of less than 1μ W. Also mutual inhibition is implemented in the chip to realize elemental image processing function.

    DOI: 10.11485/itetr.24.27.0_23

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  • A vision chip using pulse width modulation technique

    UEHARA Akihiro, TOKUDA Takashi, OHTA Jun, NUNOSHITA Masahiro

    ITE Technical Report   24 ( 3 )   19 - 24   2000.1

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    A vision chip employing pulse width modulation(PWM) circuitry in each pixel is designed and fabricated. The neighboring pixels are interconnected with active resistors to diffuse noise, which is effective to decrease fixed pattern noise from 1% to 0.2%. By using this PWM technique it is demonstrated that histogram equalization and A/D conversion can be simultaneously realized during accumulation period. A comparator, which is used for the PWM operation, consists of one capacitor and three transistors and has A/D conversion of 7-bit precision in 2 msec. 1.2μm CMOS 2-poly 2-metal process is used to fabricate the chip, which has 16 × 16 pixels with the pixel size of 158μm × 103μm. The power consumption is 300μW per pixel in the processing speed of 500 frames per second.

    DOI: 10.11485/itetr.24.3.0_19

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  • Wafer Fusion Technique Applied to GaN/GaN system(共著)

    Jpn. J. Appl. Phys. 誌   39 ( 6B )   L572 - L574   2000

  • Coherent two-dimensional lasing action in surface-emitting laser with triangular-lattice photonic crystal structure

    M Imada, S Noda, A Chutinan, T Tokuda, M Murata, G Sasaki

    APPLIED PHYSICS LETTERS   75 ( 3 )   316 - 318   1999.7

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  • Growth characteristics of GaInN on (0001)sapphire by plasma-excited organometallic vapor phase epitaxy

    T Tokuda, A Wakahara, S Noda, A Sasaki

    JOURNAL OF CRYSTAL GROWTH   187 ( 2 )   178 - 184   1998.5

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  • Substrate nitridation effect and low temperature growth of GaN on sapphire (0 0 0 1) by plasma-excited organometallic vapor-phase epitaxy

    T Tokuda, A Wakahara, S Noda, A Sasaki

    JOURNAL OF CRYSTAL GROWTH   183 ( 1-2 )   62 - 68   1998.1

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  • Compositional inhomogeneity and immiscibility of a GaInN ternary alloy

    A Wakahara, T Tokuda, XZ Dang, S Noda, A Sasaki

    APPLIED PHYSICS LETTERS   71 ( 7 )   906 - 908   1997.8

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  • Plasma-excited organometallic vapor phase epitaxy of GaN on (0001)sapphire

    T Tokuda, A Wakahara, S Noda, A Sasaki

    JOURNAL OF CRYSTAL GROWTH   173 ( 3-4 )   237 - 243   1997.4

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  • Growth of GaInN Alloy Layer and Its Compositional Inhomogeneity

    WAKAHARA Akihiro, TOKUDA Takashi, DANG Xiao-Zhong, NODA Susumu, SASAKI Akio

    IEICE technical report. Electron devices   96 ( 292 )   15 - 20   1996.10

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    Ga_<1-x>In_xN ternary alloy layer is grown by using plasma-excited metalorganic vapor phase epitaxy. It is found that GaInN alloy with whole In composition can be obtained by this growth technique and room temperature photoluminescence is obtained from the layer with In composition up to 0.25. It is also found that alloy composition become nonuniform at higher growth temperature (Tg>600℃).

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  • Growth of GaN films by plasma-excited organometallic vapor phase epitaxy

    A Wakahara, T Tokuda, A Sasaki

    SILICON CARBIDE AND RELATED MATERIALS 1995   142 ( 5章 )   883 - 886   1996

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    Web of Science

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  • Growth of GaN by Plasma-Assisted OMVPE

    TOKUDA Takashi, WAKAHRA Akihiro, SASAKI Akio

    IEICE technical report. Electron devices   95 ( 387 )   25 - 30   1995.11

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    We conducted Plasma-Assisted OMVPE of GaN on sapphire in which plasma-excited nitrogen was supplied by RF plasma cell. Crystalline quality was investigated by RHEED, X-ray diffraction, and Photoluminescence measurements. In spite of direct growth , surface of GaN layer was very flat. It is because nucleation density of Plasma-Assisted OMVPE is very high. Plasma-excited Ga is considered to play an important role on this high density nucleation.

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  • ISLAND FORMATION OF INAS GROWN ON GAAS

    Y NABETANI, N YAMAMOTO, T TOKUDA, A SASAKI

    JOURNAL OF CRYSTAL GROWTH   146 ( 1-4 )   363 - 367   1995.1

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  • 検出装置、検出方法

    徳田 崇, 太田 淳, 垣内 喜代三, 西山 靖浩, 笹川 清隆, 野田 俊彦, 竹原 宏明

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    Application no:特願2015-207524 

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  • 視覚再生補助装置

    寺澤靖雄, 田代洋行, 鐘堂健三, 太田淳, 徳田 崇, 香川景一郎

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    Application no:特願2005-232878 

    Announcement no:特開2007-044323 

    Patent/Registration no:特許4412924 

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  • 生体組織用イメージングデバイス及び生体組織用イメージング方法

    竹原 宏明, 太田 安美, 太田 淳, 徳田 崇, 笹川 清隆, 野田 俊彦

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    Application no:特願2014-177246 

    Announcement no:特開2014-177246 

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  • 生体情報取得装置

    徳田 崇, 太田 淳, 笹川 清隆, 野田 俊彦, 竹原 宏明

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    Application no:特願2015-156793 

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  • 脳機能計測装置及び計測方法

    徳田 崇, 太田 淳, 笹川清隆, 野田俊彦

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    Application no:特願2012-229419 

    Announcement no:特開2014-79387 

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  • 生体用高機能電極

    野田 俊彦, 徳田 崇, 笹川 清隆, 太田 淳

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    Application no:特願2013-028006 

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  • 固体撮像素子・及び該素子を用いた撮像装置

    徳田 崇, 太田 淳, 香川 景一郎

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    Application no:特願2006-21610 

    Announcement no:特開2007-207789 

    Patent/Registration no:特許4271917 

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  • エナジーハーベスティングによる発光デバイス

    徳田 崇, 竹原 宏明, 野田 俊彦, 笹川 清隆, 太田 淳

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    Application no:特願2016-208459 

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Awards

  • NAIST学術賞

    2013.3   奈良先端科学技術大学院大学  

    徳田 崇

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  • 第10回 LSI デザインIPアワード 開発奨励賞

    2008  

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    Country:Japan

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  • 映像情報メディア学会 丹羽高柳賞(論文賞)

    2007  

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    Country:Japan

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  • 第9回 LSI デザインIPアワード, IP賞

    2007  

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    Country:Japan

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  • 第21回 生体・生理工学シンポジウム(BPES2006), 研究奨励賞

    2006  

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    Country:Japan

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  • 第4回IUMRSアジア国際会議 Young Researcher Award

    1997  

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Research Projects

  • Development of a novel light-triggered genome editing system for the treatment of retroviral infections

    Grant number:22H00593  2022.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Grant amount:\42120000 ( Direct Cost: \32400000 、 Indirect Cost:\9720000 )

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  • Proof of concept of bottom-up IoT with energy-harvesting micro-nodes

    Grant number:19K22844  2019.6 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Challenging Research (Exploratory)  Challenging Research (Exploratory)

    Tokuda Takashi

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    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    We set the ultimate goal of this project to build an IoT framework based on ultra-small edges operated by environmental light. As the most important technical element of the technology, this work focused on a CMOS-based optical energy harvesting circuit that consists of ultra-small hpotovoltaic cells, energy-sotoring capacitor(s), CMOS voltage monitoring circuit, bias circuit, and CMOS load-driving switch. In this project, we introduced new circuit topologies on bias generation and voltage monitoring circuit. The dual-capacitor configuration employed for voltage monitroing circuit is unique design in this work. We successfully eveluated and demonstrated the basic functionalities of the circuits.

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  • Opto-Electric Brain Machine Interface using Flexible-CMOS Hybrid Technology

    Grant number:17H02222  2017.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Tokuda Takashi

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    Grant amount:\16770000 ( Direct Cost: \12900000 、 Indirect Cost:\3870000 )

    An opto-electric brain machine interface based on the planned concept was successfully developed. The device has following features:
    1, The device has a structure consisgting of multiple unit devices connected with flexible bridge structure. The strcuture can be bent two-dimensionally. 2. Each unit device is equipped with dedicated CMOS control chip. The chip can be used as a selector for multiple LED or neural electrodes on each unit device. 3. Each CMOS chip on the unit device has its unique ID and identification sequence. So multiple CMOS chip connnected on shared bus wirings (5-6 wires) can be consistently operated.

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  • 生命機能メカニズム解明のための光操作技術

    2016.10 - 2020.3

    JST  戦略的創造研究推進事業さきがけ 『生命機能メカニズム解明のための光操作技術』 

    徳田 崇

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    Grant type:Competitive

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  • フルチップ転写グラフェン-CMOS融合テクノロジーの創出

    2016.10 - 2017.9

    村田学術振興財団  研究助成 

    徳田 崇

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    Grant type:Competitive

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  • Development of cell-integrated micro-photonic device

    Grant number:16K14256  2016.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Ohta Jun, TOKUDA Takashi, SASAGWA Kiyotaka, NODA Toshihiko, TAKEHARA Hiroaki

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    We have succeeded to culture GFP expressed HeLa cells on our micro-photonic device. An adhesive layer has been developed for this purpose. The absorption filter to detect green fluorescence from GFP and block blue light from an excitation light source have already been developed in our lab and can be applied to this experiment. The whole device is put into a PBS solution.
    Next, we dropped a histamine solution onto the device. We have successfully demonstrated to obtain fluorescent image from the cells when a histamine solution is dropped. This clearly shows our device can be used as a cell-sensor to detect a chemical substance through fluorescence.

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  • Implantable glucose sensor toward fully implantable glucose monitoring system(Fostering Joint International Research)

    Grant number:15KK0209  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research)  Fund for the Promotion of Joint International Research (Fostering Joint International Research)

    Tokuda Takashi, Sawan Mohamad, Ohta Jun, Sasagawa Kiyotaka, Haruta Makito, Noda Toshihiko

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    Grant amount:\14560000 ( Direct Cost: \11200000 、 Indirect Cost:\3360000 )

    This project was performed to develop an ultra-small power receiving platform for implantable bioelectornics. The research was partly done under a collaboration with Prof. Mohamad Sawan in Polytechnique Montreal. Considering the requirements for ultra-small implantable lectronic devices, An optical powering scheme was chosen in the project. CMOS-based circuits, as well as integrated power receiving chip were designed and characterized. Some of significantly essential function were demonstrated successfully and basic characteristics of the proposed optical powering platform were analyzed and published.

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  • Development of In-line Analysis System for Organic Photoreactions with Integrated Intelligent Sensors

    Grant number:15H03544  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KAKIUCHI Kiyomi, OHTA jun, NISHIYAMA yasuhiro, NAKANO momoe, NOGUCHI jiro

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    Grant amount:\16770000 ( Direct Cost: \12900000 、 Indirect Cost:\3870000 )

    We elucidated that the fabrication of the appropriate set-up is very important for the efficient photoreaction proceeding, in addition to only utilizing microreactors. Furthermore, the slug flow mode, which is the specific flow mode in microreactors, enabled to improve the photoreaction efficiency (conversion, yield, and productivity) compared to that not only in batch reactors but also in microreactors under normal one-layer conditions. Additionally, we validated both on-chip spectrophotometry and optical rotation with CMOS image sensors for measuring photoreactions in in-line. The outcome led to the highly accurate in-line monitoring of the asymmetric photoreaction proceeding from the data of both the transmittance and optical rotation.

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  • Fully implantable brain functional measurement device

    Grant number:15K01289  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kiyotaka Sasagawa, OHTA Jun, TOKUDA Takashi, NODA Toshihiko, TAKEHARA Hiroaki

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    In this study, a distributed multiple image sensor device was developed. The control signals for the image sensor are generated in the chip. And, a chip control signal is transmitted on the power line. Thus, the number of the input lines is reduced to two. We built a multiple sensor system that sensors were driven sequentially with only two lines.
    As a way to reduce the number of lines, an implantable device based on intra-body communication technique. By contacting an image sensor with output electrodes on a mouse brain, weak electrical current signal was transmitted to another electrode on the body.

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  • 単一光子アバランシェダイオードを体内埋込撮像素子に応用した体内撮像式STS刺激方式人工視覚システムの開発

    2015.1 - 2015.12

    JST  研究成果最適展開支援プログラム(A-STEP) フィージビリティスタディ[FS] 探索タイプ 

    徳田 崇

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    Grant type:Competitive

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  • Study on microphotonic devices with bidirectional brain communication

    Grant number:26249051  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Ohta Jun, TOKUDA Takashi, SASAGAWA Kiyotaka, NODA Toshihiko

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    Grant amount:\40300000 ( Direct Cost: \31000000 、 Indirect Cost:\9300000 )

    We achieved (1) the improvement of performance of implantable devices, (2) bidirectional communication with neural networks, and (3) the establishment of out-body communication method. In high performance of implantable devices, an ultra-thin device with low-induced damage are developed and fabricated. The both functions of imaging and optical stimulation are integrated on a device and demonstrated a bidirectional communication with neural cells. In addition, we achieved optical measurement and stimulation in multiple points. Out-body communication is demonstrated in wireless manner and also demonstrated a method to transmit image data effectively.

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  • バイオインプランタブルCMOS チップによる新世代マルチモード脳皮質刺激・計測デバイス開発

    2014.4 - 2016.3

    半導体理工学研究センター(STARC)  アイディアスカウト(IS) 

    徳田 崇

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  • Fabrication and demonstration of probe device toward Smarl Skull technology

    Grant number:26630186  2014.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Tokuda Takashi, OHTA Jun, SASAGAWA Kiyotaka, NODA Toshihiko

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    Based on an idea of flexible and wide-area-covering BMI (Brain Machine Interface) device: "Smart Skull", a novel opto-electronic nerural interface device was designed, fabricated. A CMOS chip with a switching capability and integrated neural amplifier was designed. Functionality as well as the device flexibility of the device was confirmed.

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  • Development of On-time Analyzing Systems for Organic Photoreactions with Integrated Intelligent Sensors

    Grant number:24310101  2012.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kakiuchi Kiyomi, OHTA JUN, TOKUDA TAKASHI, NISHIYAMA YASUHIRO

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    Grant amount:\19890000 ( Direct Cost: \15300000 、 Indirect Cost:\4590000 )

    In this research, we designed some microflow devices for various photoreactions. We elucidated that the fabrication of the appropriate set-up is very important for the efficient photoreaction proceeding, in addition to only utilizing microreactors. Furthermore, the slug flow mode, which is the specific flow mode in microreactors, enabled to improve the photoreaction efficiency (conversion, yield, and productivity) compared to that not only in batch reactors but also in microreactors under normal one-layer conditions. Additionally, we validated both on-chip spectrophotometry and optical rotation with CMOS image sensors for measuring photoreactions on time. As a result, we achieved to monitor the asymmetric photoreaction proceeding on time from the data of both the transmittance and optical rotation.

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  • Implantable gcluose sensor toward fully implantable glucose monitoring system

    Grant number:23360157  2011.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Tokuda Takashi, OHTA Jun, SASAGAWA Kiyotaka, NODA Toshihiko, TAKEUCHI Shoji, OKITSU Teru

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    Grant amount:\19240000 ( Direct Cost: \14800000 、 Indirect Cost:\4440000 )

    An implantable glucose sensor was proposed and demonstrated. This sensor is designed based on a concept of fully-implantable glucose monitoring technology. We adopted a glucose-responsive fluorescent hydrogel as a mediator for the implantable glucose sensor. Integrating implantable CMOS imagesensor, fluorescent hydrogel, and mirco-light source (LED) we demonstrated the basic glucose sensing capability. We successfully demonstrated the sensing function in both in vitro and in vivo experiments. We also confirmed a device lifetime longer than 150 days.

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  • Micro communicator - Bio-semiconductor interface devices with ultra-low invasiveness

    Grant number:23246068  2011.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    OHTA JUN, SHIOSAKA Sadao, ZHANG Bing, LI Karen, TOKUDA Takashi, SASAGAWA Kiyotaka, NODA Toshihiko

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    Grant amount:\49270000 ( Direct Cost: \37900000 、 Indirect Cost:\11370000 )

    We proposed and demonstrated a u-COM network which enables a bio-semiconductor fusion system, and succeeded in the following results; (1) image transmission experiments through a brain as a transmission medium, (2) proposal and demonstration of an ultra-small imaging device with daisy-chain architecture to reduce wiring, and (3) demonstration of 2-dimensional communication experiments using a brain phantom. These results show a possibility for a bio-semiconductor fusion system by a u-COM brain network system.

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  • CMOS-based flexible brain stimulation / measurement device

    Grant number:23656241  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    TOKUDA Takashi, OHTA Jun, SASAGAWA Kiyotaka, NODA Toshihiko

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    A CMOS-based implantable flexible neural stimulation / measurement device was proposed and demonstrated. The most important feature of the device is its "Multi-chip architecture".
    We design a small-sized, intelligent neural interface devices ("Unit chip") and aligned them on a flexible substrate. It enables a neural stimulation / measurement device with intelligent functionality and flexibility to fit a curved tissue.We designed a CMOS unit chip and fabricated a flexible neural stimulation / measurement device for feasibility study, and obtained promising results.

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  • 光・電気マイクロチップによる高分解能ニューラルインターフェースとニューロ-LSI融合BMIの開発

    2010.10 - 2014.3

    JST  戦略的創造研究推進事業さきがけ 『脳情報の解読と制御』 

    徳田 崇

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  • Development of on time and on demand organic photoreaction system based on the time-space control

    Grant number:21310081  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KAKIUCHI Kiyomi, OHTA Jun, TOKUDA Takashi, TSUTSUMI Tsutsumi Ken, NISHIYAMA Yasuhiro

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    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

    In this work, we designed and fabricated the microflow device for photoreactions. We performed the photoreaction using a commercially available and hand-made microflow reactors, and could achieve a very highly efficient photoreaction because of very high transmission due to the very short pathlengths. Furthermore, we examined the validation of both on-chip spectrophotometry sensor and optical rotation analyzing CMOS image sensor for measuring photoreaction on time. As a result, we could elucidate that our sensor could operate favorably comparing with conventional each analysis instrument.

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  • Implantable smart CMOS neural interface chips

    Grant number:19206042  2007 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    OHTA Jun, SHIOSAKA Sadao, TOKUDA Takashi, SASAGAWA Kiyotaka, NODA Toshihiko

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    Grant amount:\48620000 ( Direct Cost: \37400000 、 Indirect Cost:\11220000 )

    We have developed micro-fluidic device integrated with fluid output function and demonstrated its fundamental operation. The fabricated device with CMOS addressing circuits successfully demonstrates a precise output function to control 5-nl volume of liquid. In addition, we have developed an implantable device to measure fluorescence as well as potential and stimulation. These results exploit a new interface technology for neural cells and CMOS chips.

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  • Development of micro-reactor system with embedded multifunctional CMOS sensor

    Grant number:18681024  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)  Grant-in-Aid for Young Scientists (A)

    TOKUDA Takashi

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    Grant amount:\29380000 ( Direct Cost: \22600000 、 Indirect Cost:\6780000 )

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  • Study on MBE technologies and optical properties of novel optical functional GeC/Si thin -epitaxial films and nanocrystal assemblies.

    Grant number:18360010  2006 - 2007

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    NUNOSHITA Masahiro, OHTA Jun, TOKUDA Takashi

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    Grant amount:\17520000 ( Direct Cost: \15300000 、 Indirect Cost:\2220000 )

    As an aim at Si-compatible light emitting or quantum information devices, we have developed new nanotechnologies of forming precisely 2-D nano-crystal (NC) assemblies of GeC, β-FeSi_2 or Si on Si (100) substrates by fusing unique bottom-up-type and top-down-type nanotechnologies such as molecular beam epitaxy (MBE), solid phase epitaxy (SPE) or ion-implantation method, respectively. The microscopic structural and optical properties of their NC assemblies were evaluated. The brief results of this research project are as follows;
    (1) For the fused nanotechnology, a novel 'nanomask' of an ultra-thin (〜2 nm thick) Si film with 2D-assembled via-holes 7±2 nm in diameter on a Si (100) wafer was developed by means of a self-assembled bio-nanoprocess using proteins 'ferritin'. It was used successfully for conventional MBE, SPE and low-energy ion-implantation techniques.
    (2) Through very small and almost 2D-ordered via-holes of the Si nanomask on the Si (100) substrate, very small-size and 2-D assembled Ge_<1-x>C_x NCs were grown by solid-source MBE with an arc-plasma gun as a C molecular beam source. The MBE-grown Ge1_<-x>Cx NCs were obtained up to a substitutional C content of x=3.2%. In the photoluminescence (PL) spectra at 7K, a PL peak appeared around 1.3 μm due to the quantum confinement effect. We could not make clear the origin of the extremely large band bowing so far.
    (3) 2-D Si-NC assemblies in SiO_2 thin films were synthesized by using very-low-energy Si^+ ion-implantation (down to 0.6keV) and sequential annealing with a Nd:YAG pulsed laser. As a result, almost ordered Si-NC assemblies with very small and uniform size (3.0±0.3 nm in diameter) and inter-particle separation (5 to 6 nm) were obtained by the transcription of the Si nanomask pattern. The PL spectra of Si-NCs implanted at 0.6keV were observed with a peak of 2lleV and an FWHM of 78 nm.
    (4) Very smallsize and high-density β-FeSi_2 NC assemblies were formed on a Si (100) substrate using an embedded solid-phase epitaxy (SPE) and bio-nanoprocess with proteins 'ferritin' containing Fe_2O_3 cores 7 nm in diameter. The β-FeSi_2 NCs were grown by SPE at 500-800℃ for 1 hr in an ultra-high vacuum chamber after embedded in an amorphous Si thin film. The β-FeSi_2 NC assemblies were almost 2D-ordered with a uniform diameter 6.3±0.3 nm and a density 6.2×10^ (11) dots/cm^2, and their PL spectra with a peak 0.91 eV were obtained

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  • 神経細胞のinvitro観察・制御用光電融合バイオインターフェイスデバイスの開発

    Grant number:16650108  2004 - 2006

    日本学術振興会  科学研究費助成事業 萌芽研究  萌芽研究

    徳田 崇, 布下 正宏, 太田 淳, 香川 景一郎

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    Grant amount:\3300000 ( Direct Cost: \3300000 )

    前年度までに0.35umルール標準CMOSプロセスを用いて試作した小型イメージセンサにより、マウス脳海馬のin vivo蛍光イメージングを行っい、マウス脳海馬におけるセリンプロテアーゼの活性発現のイメージングに成功し、マウス脳内において生じるLTP(Long Term Potentiation)に対応するとみられる酵素発現のイメージングに成功した。
    LTP発現等の高度な脳神経イメージング実験においては、これまで開発したin vivoイメージングモジュールに加え、励起光導入用光ファイバ、刺激電極、計測電極などを実験対象の脳に埋め込む必要がある。本研究では、イメージングの高機能化への対応として、イメージセンサに裏面からチップ面を通して励起光や薬物を導入するための貫通穴を形成することを試みた。また同時に、イメージセンサ上に刺激・計測電極の集積化を行った。これらの新機能を実証するイメージセンサデバイスを試作し、実装した上で、高機能化の実証(励起光導入.電気刺激機能)に成功した。

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  • Research on Bio-Photonic Devices Based on Distributed Architecture

    Grant number:16360175  2004 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    OHTA Jun, NUNOSHITA Masahiro, TOKUDA Takashi, KAGAWA Keiichiro

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    Grant amount:\14900000 ( Direct Cost: \14900000 )

    The main theme throughout this entire research is the application of CMOS image sensors for bioimaging applications. We adopted the use of a CMOS technology for fabrication of the sensor due to the possibility of multiparameter sensing. In this work, we have explored and solved many issues related to photosensing, fluorescence detection, packaging for on-chip imaging, and electrical stimulation. When applied for in vivo imaging, initially we encountered some difficulties in providing sufficient excitation light inside the mouse brain. However, this issue was resolved during in vivo verification imaging by using the brain phantom and illumination light from a fiber tip. We found that when the tip is brought to about 1 mm from the sensor surface, sufficiently uniform excitation light was obtained. This has finally led to the successful in vivo fluorescence imaging and quantitative measurement of the AMC fluorophore. We believe that this work is important as it represents the first reported work of using a CMOS image sensor for functional imaging inside the intact mouse brain. From this work, we have gained important insight into the pulse modulation photosensing method and realized that more work would be needed in order to develop a pulse modulation based image sensor with fast frame rate imaging.

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  • Si LSI によるインテリジェントバイオセンシングチップおよび超小型バイオセンシングシステムの開発

    2004 - 2006

    NEDO  産業技術研究助成 

    徳田 崇

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    Grant type:Competitive

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  • 強誘電体ナノ単結晶構造の物性解明と新機能電気光学デバイスの創出

    Grant number:14702035  2002 - 2004

    日本学術振興会  科学研究費助成事業 若手研究(A)  若手研究(A)

    徳田 崇

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    Grant amount:\24960000 ( Direct Cost: \19200000 、 Indirect Cost:\5760000 )

    強誘電体の微細構造形成手法として、ゾルゲル法による薄膜形成を採用し、その形成条件を構造解析を行った。また、横方向のナノサイズ化を目的として、リソグラフィによる熱処理前・後の加工について検討を行った。さらに成膜・加工によって形成した強誘電体微細構造に対して種々の評価を行った。
    1.STO基板上および石英基板上にに室温アモルファス製膜、空気中アニールによりきわめて結晶性の良好なPZTおよびPLZT薄膜を得ることに成功した特にSTO基板上においては、X線回折測定において(001)方向にきわめて強く配向したエピタキシャル構造を得ることができた。
    2.厚さ100nm以下の極薄PLZT膜において、圧電応答顕微鏡観察により、ヒステリシスを確認した。このヒステリシス特性は電解による強誘電-リラクサ相転移によるものと考察された。

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  • 強誘電体中の動的フォトニック結晶形成と光伝搬制御の研究

    2002 - 2003

    光科学技術研究振興財団  研究助成 

    徳田 崇

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    Grant type:Competitive

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  • A Smart Image Sensor in Eye-Sage Band with Demodulation Function

    Grant number:13450144  2001 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    OHTA Jun, KAGAWA Keiichiro, TOKUDA Takashi, NUNOSHITA Masahiro, SUGISHITA Syouzou

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    Grant amount:\14700000 ( Direct Cost: \14700000 )

    An image sensor with an in-pixel demodulation function for detecting modulated light is proposed and demonstrated. The pixel has two floating diffusion regions, one of which stores charges produced by static illumination, and the other stores charges produced by both static and modulated illumination. By subtracting the two outputs, images produced only by the modulated illumination can be obtained. Based on the proposed circuit, an image sensor with 64 x 64 pixels is lubricated using a 0.6μm 2-poly 3-metal CMOS technology. Using this sensor, we successfully demonstrate the extraction of the modulated component of images under constant illumination conditions. In addition, for the application of motion capture, we demonstrate that a marker, which is a modulated light source, can be extracted from a captured image under several light conditions by using this sensor. Finally, means of improving the characteristics of charge transfer efficiency are discussed.
    We have also demonstrated an image sensor using SiGe BiCMOS fabrication process for detecting object illuminated by light in "eye-safe" band. The fabrication process is general 0.8μm 2-poly 2-metal SiGe BiCMOS process for RF application. SiGe-Si photodiodes and Si-SiGe-Si hetero-phototransistors as well as Si homojunction photodiodes and phototransistors have been fabricated and measured. The gain of the hetero-phototransistor was around 100. There was little difference between the sensitivity characteristics of SiGe and Si photodetectors. An image sensor with 32x32 pixels has been fabricated using a phototransistor as a detector, which of the base is made of SiGe layer. The dynamic range was 23 dB and the minimum detectable light intensity was 10 lux. We have successfully quired images by using this image sensor. The future issues to use SiGe BiCMOS process for image sensors are discussed.

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  • 低電圧駆動パルス周波数変調方式を用いたビジョンチップの研究

    Grant number:13023207  2001 - 2002

    日本学術振興会  科学研究費助成事業  特定領域研究

    太田 淳, 香川 景一郎, 徳田 崇, 布下 正宏

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    Grant amount:\4800000 ( Direct Cost: \4800000 )

    パルス周波数変調方式(PFM)はアナログ出力をパルス周波数に変換する方式であり,神経節における出力方式として用いられている.我々はこれまでPFM方式の画素回路を試作し,その基本特性の検証を行ってきた.PFM方式ビジョンチップの低電圧駆動時の動作を詳細に検討した.低電圧下では光電流と充電電流が拮抗するため充電時間が長くなり,その結果パルス幅が広がり,これがパルス出力特性を劣化させていることが分かった.
    また128×128画素PFMアレイチップを試作し,撮像による基本特性を確認した.PFMは非同期動作が可能なため個々の画素は独立して動作する.従って本センセは通常と異なり走査用のスキャナが不要であり,代わりに外部からの任意画素アクセスを可能とするデコーダを搭載している.消費電力は画素当り約7μWであった.
    更に出力周波数範囲を限定しつつ入力光範囲を拡大する感度可変方式について提案し,基本特性の実証を行った.オリジナルで6桁の入力光範囲を周波数大域制限をかけることで2桁に減少するが,感度可変機能を導入することでトータルとして5桁程度の入力光範囲を確保できた.またPFM出力を可視化するためのデモ装置を試作した.チップは32x32画素であり,その出力を32x32画素を有するLEDディスプレイ上にリアルタイムで表示することに成功した.

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  • GeC系半導体の結晶成長と光デバイスの研究

    2001

    村田学術振興財団  研究助成 

    徳田 崇

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    Grant type:Competitive

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  • Development of Retinal Prosthesis Device

    2000

    Health and Labour Sciences Research Grants 

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    Grant type:Competitive

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  • パルス周波数変調法を用いたビジョンチップの研究

    Grant number:12044210  2000

    日本学術振興会  科学研究費助成事業  特定領域研究(A)

    太田 淳, 徳田 崇, 布下 正宏

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    Grant amount:\2800000 ( Direct Cost: \2800000 )

    ビジョンチップは画素内に受光素子と信号処理回路を集積化することで,生体視覚情報処理系の有する柔軟かつ高速な画像処理を実現しようとするものである。近年のLSIの微細化・高集積化の流れは,処理機能を画素内に集積化しているビジョンチップにとって有利である一方,微細化にともなう電源電圧の低電圧化は光強度信号のセンシングの観点からSN比の劣化につながり不利な条件となると予想される。また受光素子であるフォトダイオードは微細化によりサイズが縮小していくと信号量が減少しSN比の劣化を生じる。従って,高集積化が必要とされるビジョンチップにとってLSI微細化のトレンドを有効に活用するためには,電源の低電圧化とフォトダイオードサイズ微細化に対応できる受光方式が重要となってくる。
    ビジョンチップはその信号処理形態の観点から,アナログ方式とデジタル方式に大別される。一方生体神経系ではパルス頻度信号(パルス周波数変調;Pulse Frequency Modulation,PFM)により情報が表現されており,このパルス信号により一種のアナログ・デジタル融合が実現されており,信号伝達におけるノイズ耐性を高めていると同時に,パルス間のシンクロナイゼーション機能により高次の処理を可能としている。このようなPFMをビジョンチップに導入することで,従来にない柔軟で知的な処理機能を高いノイズ耐性の下で実現が可能になると期待される。
    本研究ではアナログ・デジタル融合方式であるパルス周波数変調方式を光信号検出手段として用いたビジョンチップ画素回路特性について報告する。CMOS0.35μmルールにより1μm角開口を有する2μm角サイズのフォトダイオードとパルス周波数変調回路を集積化した画素回路を試作した。本試作回路を評価した結果,電源電圧0.6Vの低電圧動作でダイナミックレンジ50dB以上の特性を確認した。

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  • Microscopic structurte, electrical and optical properties of ferroelectric ultra-thin films

    Grant number:11450251  1999 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    NUNOSHITA Masahiro, SUZUKI Yoshihiko, TOKUDA Takashi, OHTA Jun

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    Grant amount:\14800000 ( Direct Cost: \14800000 )

    Ferroelectric ultra-thin films were grown and characterized by means of novel microscopic measurement methods. PZT(52/48) which is suitable for ferroelectric memory devices and PLZT(8/65/35) which is suitable for electro-optic devices were chosen as the target materials. Near-field optical microscopy and piezoelectric SPM were applied to investigate microscopic optical and ferroelectric properties of the PZT and PLZT ultra-thin films. The results of the research project are as follows ;
    1. The both of the size of the grains and the remanent polarization of the PZT(52/48) and PLZT(8/65/35) thin films on Pt/Ti/Si0_2 increase with an increase of the film thickness.
    2. A specific contrast is observed in the SNOM images of the PZT and PLZT thin films. The contrast may be in relation to the ferroelectricity.
    3. The PZT and PLZT thin films are preferably (111)-oriented polycrystalline on Pt/Ti/Si0_2 and ITO/Si0_2 substrates. The films include pyrochbre phase or PbO_2 extraction. On the other hand, A high-quality (FWHM of XRD rocking curve is smaller than 200arcsec) (001)-oriented epitaxial P(L)ZT films are obtained on STO(001) substrates.
    4. By means of a piezoelectric SPM observation, the existence of ferroelectricity in P(L)ZT ultra-thin films was confirmed. The size of the domain is smaller than 1 um. However, the deterioration of the retention property was observed in ultra-thin films.
    5. The problem of the artifacts observed in SNOM images was discussed experimentally and theoretically.
    6. By means of a multi-step deposition, an arrayed PZT diaphragm micro sensor was developed.

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  • Study on a vision chip based on asynchronous operation

    Grant number:11650348  1999 - 2000

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OHTA Jun, TOKUDA Takashi, NUNOSHITA Masahiro

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    Grant amount:\3800000 ( Direct Cost: \3800000 )

    In the first year we have studied a vision chip based on non-accumulation mode and its application. First of all we have evaluated photo-transistors, which are essential devices to non-accumulation mode. Next by using the non-accumulation mode we have proposed a vision chip which can take image without being affected by surrounding illumination. This chip can extract only modulated signals from reflected light signals. The simulation results have showed a proper operation. The proposed chip consists of photo-sensing part, a demodulation circuit, an averaging circuit, and a sensitivity correction circuit. To detect a small modulated signals on a strong background illumination, Darlington connected photo-transistors have been employed due to their high gain. To suppress the non-uniform gain we have introduced a sensitivity correction circuit. We have designed the circuits and demonstrated their effectiveness by HSPCIE simulation.
    In the second year we have studied on high performance of photo-sensing circuit. Floating diffusion has been used to improve the sensitivity and suppress the noise. Standard CMOS fabrication process has been applied to make two types of sensor chip ; photo-gate type and photodiode type. The used process is 0.35μm double poly double metal CMOS.We have preliminary showed the fundamental characteristics of photo-gate type sensor.

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  • SiGe/Si超格子ヘテロフォトトランジスタを用いたビジョンチップに関する研究

    Grant number:11167256  1999 - 2000

    日本学術振興会  科学研究費助成事業  特定領域研究(A)

    太田 淳, 徳田 崇, 布下 正宏

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    Grant amount:\3700000 ( Direct Cost: \3700000 )

    Si_<1-x>Ge_xはその吸収端が1.1〜1.95μmと組成xに応じて変化する材料であり,光通信で重要な1.3μm及び1.55μm用受光素子への適用を目指した研究がなされている。この波長帯がイメージセンサとして重要な点は,人間の目に対する被曝許容量が高い波長1.4μm〜1.8μmの光,所謂「アイセーフ帯」をカバーしていることである。照明光を変調して物体に照射し,その反射光から変調光のみ検波することで背景光に依存しない撮像が可能となる方式が提案されており,その変調照明光としてアイセーフ帯を用いることで,比較的強度の高い光を照射できる。
    このような変調光検波処理回路とアイセーフ帯受光素子とを画素内に集積化したイメージセンサであるビジョンチップは,SiGe BiCMOSプロセスを用いることで可能となると期待される。我々はこれまでSiGeを用いたアイセーフ帯ビジョンチップの提案と基本検討を行ってきた。今回,アイセーフ帯ビジョンチップへの適用を目指して,RF用のSiGe BiCMOSプロセスを用いて受光素子及びベース層にSiGeを用いたヘテロフォトトランジスタを受光素子として用いた32×32画素イメージセンサを試作し,その基本特性評価を行った。また,今後の展開としてSiGe BiCMOSプロセスを用いた高効率受光素子構造に関しての考察を行った。

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