Updated on 2026/03/25
1997年 東京農工大学 工学部 卒業
1999年 東京工業大学大学院 総合理工学研究科 修士課程修了
2002年 名古屋大学大学院 工学研究科 博士課程修了 博士（工学）
2002～2003年 日本学術振興会 特別研究員 PD
2003～2008年 東京大学大学院 工学系研究科 応用化学専攻 助手
2008～2016年 東京工業大学 資源化学研究所 准教授
2016～2020年 東京工業大学 科学技術創成研究院 化学生命科学研究所 准教授
2020年～現在 東京工業大学 科学技術創成研究院 化学生命科学研究所 教授
A First for Ferrocene: Organometallic Capsule with Unusual Charge-Transfer Interactions
2023/09/01
Languages： English
An organometallic capsule that can reversibly assemble and disassemble in response to chemical stimuli was recently developed by chemists at Tokyo Tech. Comprising ferrocene-based bent amphiphile
サンドイッチ分子からなるナノカプセル 電子の授受でカプセル構造の集合と分散を操る
2023/09/01
Languages： Japanese
要点-サンドイッチ型分子「フェロセン」の殻を持つカプセル構築に成功-平面状・球状分子の効率的な内包と外部刺激（電子授受）による放出を達成-電子不足分子の内包により近赤外線領域に幅広の吸収特性を誘起概要東京工業大学物質理工学院応用化学系の遠山
色素分子を「ねじる」と「かさねる」 分子カプセルの新たな空間機能を開発
2021/04/12
Languages： Japanese
要点-カルバゾール環の殻を持つ水溶性の分子カプセルを作製-電気化学的刺激に対してカプセル構造は高い安定性を示す-内包によりクマリン色素の「ねじれ構造」を誘起-内包でBODIPY色素はL型「かさなり構造」を形成概要東京工業大学科学技術創成研究院の吉沢道人教授、東京工業高等専門学校の工藤光日（専攻科2年
性ホルモンの男女を見分ける分子カプセル 男性ステロイドホルモンの超高感度センシング法を開発
2019/04/22
Languages： Japanese
水中で分子カプセルが種々のステロイド性ホルモンを強く捕捉 男性と女性ホルモンの混合物から男性ホルモンを選択的に捕捉 数ナノグラム量の男性ホルモンの高感度蛍光センシングに成功
2019/04/22
Languages： English
Researchers at Tokyo Tech have revealed that an artificial receptor preferentially binds male steroid hormones from a mixture of male and female hormones in water. Based on their findings, they succeeded in the preparation of a prototype detection system for male hormones at the nanogram level. This achievement could lead to the development of ultrasensitive analytical devices for medical diagnostics and anti-doping testing in sports.
ナノグラフェンを水に溶かして分子膜作製に成功 次世代材料ナノグラフェン研究に新たな扉
2018/10/31
Languages： Japanese
溶媒に溶けにくいナノグラフェンの水溶化に成功 水中でナノグラフェン分子膜作製を可能とする「分子コンテナ」を利用した環境にやさしい新手法を開発 次世代の機能性ナノ材料の作製や分析に期待
ナノカプセルを貫く分子のひもを発見 混ぜるだけで組み上がる 新たな貫通型ナノ構造体
2018/10/15
Languages： Japanese
ひも状のオリゴマー分子が、水中でナノカプセルと強く結合 短い分子は包み込み、長い分子は貫き通し構造を瞬時に形成 2つの様式の構造形成の鍵は、カプセル内での多点相互作用
“バイオプラスチック”を捕まえるナノカプセル 疎水性ナノ空間による親水性乳酸オリゴマーの捕捉に成功
2018/03/09
Languages： Japanese
ナノカプセルの疎水性空間が、水中で親水性の乳酸オリゴマーを内包。加水分解性の環状乳酸2量体は、ナノカプセル空間内で顕著に安定化。多点の分子間相互作用（エンタルピー駆動）により、内包体を安定化。
2017/10/02
Languages： Japanese
分子カプセルの包み込みによる硫黄ナノクラスターの新しい質量分析法を開発カプセル空間内で硫黄ナノクラスターの顕著な安定化と選択的合成に成功
Sweet success: Nanocapsule perfectly binds sucrose in water
2017/09/08
Languages： English
Scientists around the world are pursuing the goal of developing synthetic receptors capable of recognizing biologically important molecules. Although many attempts have been made to mimic the way that protein pockets detect sugar dissolved in water with hydrogen bonding interactions, few have succeeded, mainly due to the interfering nature of water molecules. Now, a Japanese team of researchers has proposed a brand new approach.
2017/09/05
Languages： Japanese
分子カプセルが、水中で砂糖の主成分スクロースを選択的に包み込むことを発見包み込みは人工の糖分子（人工甘味料）の方が強く、人間が感じる甘さと同じ順
2017/07/07
Languages： Japanese
W型有機分子と金属イオンから、3ナノメートルのピーナッツ型分子を作製 2種類の化学結合を利用した、複雑なコアシェル構造の簡便合成法を開発
2014/10/28
Languages： Japanese
Stabilization of Highly Reactive Reagents upon Encapsulation
2014/09/24
Languages： English
2014/08/22
Languages： Japanese
蛍光性の「殻」をもつ新型ミセルを作製 ー 色素分子の内包による特異な蛍光性能の発現 ー
2013/01/25
Languages： Japanese
東京工業大学資源化学研究所の吉沢道人准教授と近藤圭大学院生らは、蛍光を発するカプセル型のミセルを開発した。今回の研究は、ミセルの構成成分として、蛍光性でパネル状のアントラセンを含む“湾曲型”の両親媒性分子を開発することで実現した。この新型ミセルは、ナノレベルでサイズ制御が可能で、色素分子を内包し、特異な蛍光性能を備えているため、新しい有機発光性材料（有機ELや蛍光センサー・プローブ、蛍光塗料など）への応用が期待される。
2013/01/25
Languages： English
A new form of micelle, which is composed of detergents with bent aromatic panels, has been created by Michito Yoshizawa and his colleagues at Tokyo Institute of Technology. Unlike traditional micelles, the new ‘aromatic micelles’ are photoactive, and capable of encapsulating dye molecules and showing unusual fluorescence in aqueous solutions. “The present micelles might be suitable for potential applications in the fields of photofunctional dyes, sensors, and materials owing to their ability to accommodate dye molecules and their efficient host-guest energy transfer in aqueous media,” explain the researchers. They also emphasise the straightforward synthesis, aqueous green chemistry and high stability of the aromatic micelles.
Blue-fluorescent molecular nanocapsules
2012/07/17
Languages： English
Michito Yoshizawa, Zhiou Li, and collaborators at Tokyo Institute of Technology synthesized ~1 nanometer-sized molecular capsules with an isolated cavity using green and inexpensive zinc and copper ions. In sharp contrast to previous molecular capsules and cages composed of precious metal ions such as palladium and platinum, these nanocapsules emit blue fluorescence with 80% efficiency.Molecular nanocapsules have potential applications as photo-functional compounds and materials but so far molecular capsules synthesized by incorporating palladium ions and so on exhibit poor fluorescence. The researchers expect to be able to prepare multicolor fluorescence composites by the simple insertion of appropriate fluorescent molecules into the isolated cavity of the nanocapsules.
2009/03/10
Languages： Japanese
東京工業大学資源化学研究所の吉沢道人准教授らは、溶液中でバラバラに存在する芳香族分子をナノメートルサイズ（用語１）の空間内で、「数」と「向き」をそろえて正確に積み重ねることに世界で初めて成功した（図１）。すなわち、自己組織化により組み上がった箱型化合物（図２）のナノ空間を活用することで、３つの極性芳香族分子（図３;用語２）の選択的な集積化を達成し、しかもそれらが集積体の双極子モーメント（用語３）をキャンセルして、120度ずつずれて配向することを明らかにした（図４）。さらに、この三重集積体では、個々の分子では見られない特異な分光学的性質が観測された。この分子集積法では、必要成分を加熱・撹拌するだけと簡便かつ汎用性が高いため、未開拓な分子間相互作用の誘起や新規な機能性材料開発に威力を発揮することが期待される。
工学 ( 2002.3 名古屋大学 )
Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry
Nanotechnology/Materials / Inorganic/coordination chemistry
Nanotechnology/Materials / Nanometer-scale chemistry
Tokyo Institute of Technology Professor
2020.4
Tokyo Institute of Technology Associate Professor
2016.4 - 2020.3
Tokyo Institute of Technology Associate Professor
2008.4 - 2016.3
The University of Tokyo
2003.1 - 2008.3
Supramolecular Singlet Fission of Pentacene Dimers within Polyaromatic Capsules Reviewed
Lorenzo Catti, Haruna Narita, Yuya Tanaka, Hayato Sakai, Taku Hasobe, Nikolai Tkachenko, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 143 ( 25 ) 9361 - 9367 2021.6
Three host peculiarities of a cycloalkane-based micelle toward large metal-complex guests Reviewed
Mamiko Hanafusa, Yamato Tsuchida, Kyosuke Matsumoto, Kei Kondo, Michito Yoshizawa
NATURE COMMUNICATIONS 11 ( 1 ) 2020.12
Bent Anthracene Dinners as Versatile Building Blocks for Supramolecular Capsules Reviewed
Michito Yoshizawa, Lorenzo Catti
ACCOUNTS OF CHEMICAL RESEARCH 52 ( 8 ) 2392 - 2404 2019.8
Polyaromatic nanocapsules as photoresponsive hosts in water Reviewed
Lorenzo Catti, Natsuki Kishida, Tomokuni Kai, Munetaka Akita, Michito Yoshizawa
NATURE COMMUNICATIONS 10 2019.4
A polyaromatic receptor with high androgen affinity Reviewed
Masahiro Yamashina, Takahiro Tsutsui, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
SCIENCE ADVANCES 5 ( 4 ) 2019.4
Exact mass analysis of sulfur clusters upon encapsulation by a polyaromatic capsular matrix Reviewed
Sho Matsuno, Masahiro Yamashina, Yoshihisa Sei, Munetaka Akita, Akiyoshi Kuzume, Kimihisa Yamamoto, Michito Yoshizawa
NATURE COMMUNICATIONS 8 2017.9
A polyaromatic nanocapsule as a sucrose receptor in water Reviewed
Masahiro Yamashina, Munetaka Akita, Taisuke Hasegawa, Shigehiko Hayashi, Michito Yoshizawa
SCIENCE ADVANCES 3 ( 8 ) 2017.8
Construction of Well-Defined Yet Adaptable Oligo(Amino Acid) Cavities within an Aromatic Micelle
Yuta Kikuchi, Lorenzo Catti, Shinji Aoyama, Tomohisa Sawada, Michito Yoshizawa
Journal of the American Chemical Society 2025.12
Hybridized Host Functions in Polyaromatic Tube-in-Capsule Composites
Daito Kidoh, Lorenzo Catti, Shinji Aoyama, Daiki Tauchi, Masashi Hasegawa, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025.12
Multinuclear CunSm clusters encapsulated by aromatic micelles as aqueous red-to-NIR phosphorescent ink Reviewed
Kazuki Toyama, Yuya Tanaka, Michito Yoshizawa
CHEMICAL SCIENCE 16 ( 36 ) 16751 - 16756 2025.9
An M60L60 metal-peptide capsid with a 60-crossing woven network Reviewed
Yuuki Inomata, Sota Oguma, Nao Sagara, Ami Nishijima, Yuta Saburomaru, Satoshi Yoshida, Takashi Kajitani, Koya Shimokawa, Sota Sato, Michito Yoshizawa, Makoto Fujita, Tomohisa Sawada
CHEM 11 ( 9 ) 2025.9
A Polyaromatic Metallotube With a Dual Multi-Functionalization Ability Reviewed
Koki Tagai, Yuya Tanaka, Michio Yamada, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 ( 34 ) 2025.8
Chiral Aromatic Micelles as Chiroptical Host Tools for Large Metallodyes in Water Reviewed
Yoshihisa Hashimoto, Yuya Tanaka, Si-Yu Liu, Hiroshi Shinokubo, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 ( 26 ) 23060 - 23067 2025.6
Design of Aromatic Interaction Networks in a Protein Cage Modulated by Fluorescent Ligand Binding Reviewed
Yuki Hishikawa, Taiga Suzuki, Basudev Maity, Hiroki Noya, Michito Yoshizawa, Asuka Asanuma, Yuri Katagiri, Satoshi Abe, Satoru Nagatoishi, Kouhei Tsumoto, Takafumi Ueno
ADVANCED SCIENCE 12 ( 15 ) 2025.4
Discrimination of Perfluorinated Arenes/Alkanes by Modulable Polyaromatic Capsules Reviewed
Urara Kai, Ryuki Sumida, Yuya Tanaka, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 ( 12 ) 10640 - 10646 2025.3
Optical Axial Chirality Enhancement and Transfer within Aromatic Micelles upon (Co-)encapsulation Reviewed
Tomohiro Yasuda, Yoshihisa Hashimoto, Yuya Tanaka, Daiki Tauchi, Masashi Hasegawa, Yusuke Kurita, Hidetoshi Kawai, Yoshitaka Tsuchido, Michito Yoshizawa
JACS Au 5 ( 2 ) 586 - 592 2025.2
A Photolockable Polyaromatic Capsule Designed via Regiochemical Substitution Reviewed
Lorenzo Catti, Shiina Yasugami, Shinji Aoyama, Natsuki Kishida, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 31 ( 3 ) 2025.1
Remote optical chirality transfer via helical polyaromatic capsules upon encapsulation Reviewed
Hayate Sasafuchi, Mayuko Ueda, Natsuki Kishida, Tomohisa Sawada, Seika Suzuki, Yoshitane Imai, Michito Yoshizawa
Chem 11 ( 3 ) 2024.10
Chiroptically Active Host-Guest Composites Using a Terpene-Based Micellar Capsule Reviewed
Yoshihisa Hashimoto, Yuya Tanaka, Daiya Suzuki, Yoshitane Imai, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 146 ( 34 ) 23669 - 23673 2024.8
Umbrella-Shaped Amphiphiles: Internal Alkylation of an Aromatic Micelle and Its Impact on Cavity Features Reviewed
Masaya Endo, Shinji Aoyama, Yoshitaka Tsuchido, Lorenzo Catti, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 ( 26 ) 2024.6
Bioinspired Binding and Conversion of Linear Monoterpenes by Polyaromatic Coordination Capsules Reviewed
Ryuki Sumida, Lorenzo Catti, Michito Yoshizawa
ACS ORGANIC & INORGANIC AU 4 ( 4 ) 410 - 417 2024.5
Facile access to pyridinium-based bent aromatic amphiphiles: nonionic surface modification of nanocarbons in water Reviewed
Lorenzo Catti, Shinji Aoyama, Michito Yoshizawa
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 20 32 - 40 2024.1
Helicity control of a polyaromatic coordination capsule through stereoselective CH–π interactions Reviewed
Natsuki Kishida, Hayate Sasafuchi, Tomohisa Sawada, Michito Yoshizawa
Chemical Science 15 ( 33 ) 13234 - 13239 2024
Solution-state mechanochromic luminescence of Pt(II)-complexes displayed within micellar aromatic capsules Reviewed
Yoshihisa Hashimoto, Yuri Katagiri, Yuya Tanaka, Michito Yoshizawa
CHEMICAL SCIENCE 14 ( 48 ) 14211 - 14216 2023.12
A Closed Cavity Strategy for Selective Dipeptide Binding by a Polyaromatic Receptor in Water Reviewed
Mayu Shuto, Ryuki Sumida, Mana Yuasa, Tomohisa Sawada, Michito Yoshizawa
JACS AU 2023.10
A Redox-Responsive Ferrocene-Based Capsule Displaying Unusual Encapsulation-Induced Charge-Transfer Interactions Reviewed
Kazuki Toyama, Yuya Tanaka, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 62 ( 37 ) 2023.9
Facile Processing of Unsubstituted π-Conjugated Aromatic Polymers through Water-solubilization Using Aromatic Micelles Reviewed
Shinji Aoyama, Lorenzo Catti, Michito Yoshizawa
Angewandte Chemie International Edition 62 ( 31 ) 2023.6
Aromatic micelles: toward a third-generation of micelles Reviewed
Michito YOSHIZAWA, Lorenzo CATTI
Proceedings of the Japan Academy, Series B 99 ( 1 ) 29 - 38 2023.1
Ryuki Sumida, Takeshi Matsumoto, Toshiyuki Yokoi, Michito Yoshizawa
Chemistry – A European Journal 28 ( 72 ) 2022.10
CH‐π Multi‐Interaction‐Driven Recognition and Isolation of Planar Compounds in a Spheroidal Polyaromatic Cavity Reviewed
Natsuki Kishida, Yuya Tanaka, Michito Yoshizawa
Chemistry – A European Journal 28 ( 69 ) 2022.10
Realization of Stacked-Ring Aromaticity in a Water-Soluble Micellar Capsule Reviewed International coauthorship
Si-Yu Liu, Natsuki Kishida, Jinseok Kim, Norihito Fukui, Rie Haruki, Yasuhiro Niwa, Reiji Kumai, Dongho Kim, Michito Yoshizawa, Hiroshi Shinokubo
Journal of the American Chemical Society 145 ( 4 ) 2135 - 2141 2022.10
Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water Reviewed
Takashi Koike, Munetaka Akita, Yuki Hyodo, Keigo Takahashi, Youhei Chitose, Manabu Abe, Michito Yoshizawa
Synlett 33 ( 12 ) 1184 - 1188 2022.7
Aqueous polyaromatic receptors for biomolecules with high selectivity Reviewed
Lorenzo Catti, Ryuki Sumida, Michito Yoshizawa
Coordination Chemistry Reviews 460 214460 - 214460 2022.6
Selective Encapsulation and Unusual Stabilization of cis-Isomers by a Spherical Polyaromatic Cavity Reviewed
Mana Yuasa, Ryuki Sumida, Yuya Tanaka, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 28 ( 10 ) 2022.2
Nanoreactor functions of a water-soluble molecular capsule for electrochemical reactions of Fe-porphyrins and phthalocyanines Reviewed
Soichiro Yoshimoto, Shunta Hashiguchi, Yukina Maruyama, Sakura Origuchi, Yuri Katagiri, Michito Yoshizawa
Electrochemistry Communications 135 2022.2
Functional Coordination Capsules Featuring Bent Anthracene Dimers Reviewed
Natsuki Kishida, Michito Yoshizawa
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 80 ( 5 ) 412 - 420 2022
Caged bulky organic dyes in a polyaromatic framework and their spectroscopic peculiarities Reviewed
Mayuko Ueda, Natsuki Kishida, Lorenzo Catti, Michito Yoshizawa
Chemical Science 13 ( 29 ) 8642 - 8648 2022
An Adamantane Capsule and its Efficient Uptake of Spherical Guests up to 3 nm in Water Reviewed
Yuri Katagiri, Yamato Tsuchida, Yutaka Matsuo, Michito Yoshizawa
Journal of the American Chemical Society 143 ( 51 ) 21492 - 21496 2021.12
Synthesis of Azaylide-Based Amphiphiles by the Staudinger Reaction Reviewed
Masahiro Yamashina, Hayate Suzuki, Natsuki Kishida, Michito Yoshizawa, Shinji Toyota
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 ( 33 ) 17915 - 17919 2021.8
Cyclic monoterpenes trapped in a polyaromatic capsule: unusual selectivity, isomerization, and volatility suppression Reviewed
Ryuki Sumida, Yuya Tanaka, Keita Niki, Yoshihisa Sei, Shinji Toyota, Michito Yoshizawa
CHEMICAL SCIENCE 12 ( 29 ) 9946 - 9951 2021.8
Formation of Hydrophobic Nanographene Adlayers Using Water-soluble Micellar Capsules
Sakura ORIGUCHI, Tomoko MURAOKA, Senri SASANO, Shunta HASHIGUCHI, Tsuyoshi FUKAMINATO, Michito YOSHIZAWA, Soichiro YOSHIMOTO
Vacuum and Surface Science 64 ( 7 ) 306 - 311 2021.7
An Aromatic Oligomer Micelle: Large Enthalpic Stabilization and Selective Oligothiophene Uptake Reviewed
Yamato Tsuchida, Keisuke Aratsu, Shuichi Hiraoka, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 ( 23 ) 12754 - 12758 2021.6
An Aromatic Micelle-Based Saccharide Cluster with Changeable Fluorescent Color and its Protein Interactions Reviewed
Haruna Narita, Lorenzo Catti, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 ( 23 ) 12791 - 12795 2021.6
Preparation of a Multicarbazole-Based Nanocapsule Capable of Largely Modulating Guest Spectroscopic Properties in Water Reviewed
Kohi Kudo, Tomohito Ide, Natsuki Kishida, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 ( 19 ) 10552 - 10556 2021.5
Transition Metal-Free Supramolecular Photoredox Catalysis in Water: A Phenoxazine Photocatalyst Encapsulated in V-Shaped Aromatic Amphiphiles Reviewed
Naoki Noto, Yuki Hyodo, Michito Yoshizawa, Takashi Koike, Munetaka Akita
ACS CATALYSIS 10 ( 23 ) 14283 - 14289 2020.12
Enhanced cellular uptake of platinum by a tetracationic Pt(II) nanocapsule and its implications to cancer treatment Reviewed
Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Tsvetelina Paunova-Krasteva, Lyuben Mihaylov, Stoyanka Stoitsova, Diana Nihtianova, Georgi Momekov, Denitsa Momekova, Michito Yoshizawa
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 155 2020.12
Highly Ordered Adlayer Formation of Water-Insoluble Nanographenes on Gold Using "Molecular Container"
Soichiro Yoshimoto, Sakura Origuchi, Senri Sasano, Shunta Hashiguchi, Tsuyoshi Fukaminato, Michito Yoshizawa
ECS Meeting Abstracts {MA}2020-02 ( 60 ) 3027 - 3027 2020.11
N-Doping of Polyaromatic Capsules: Small Cavity Modification Leads to Large Change in Host-Guest Interactions Reviewed
Hiroki Dobashi, Lorenzo Catti, Yuya Tanaka, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 ( 29 ) 11881 - 11885 2020.7
Recognition and Stabilization of Unsaturated Fatty Acids by a Polyaromatic Receptor Reviewed
Keita Niki, Takahiro Tsutsui, Masahiro Yamashina, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 ( 26 ) 10489 - 10492 2020.6
Polyaromatic Nanotweezers on Semiconducting Carbon Nanotubes for the Growth and Interfacing of Lead Halide Perovskite Crystal Grains in Solar Cells Reviewed
Hao-Sheng Lin, Shunhei Okawa, Yue Ma, Satoshi Yotsumoto, Changsoo Lee, Shaun Tan, Sergei Manzhos, Michito Yoshizawa, Shohei Chiashi, Hyuck Mo Lee, Takeshi Tanaka, Hiromichi Kataura, Il Jeon, Yutaka Matsuo, Shigeo Maruyama
CHEMISTRY OF MATERIALS 32 ( 12 ) 5125 - 5133 2020.6
Anisotropic Contraction of a Polyaromatic Capsule and Its Cavity-Induced Compression Effect Reviewed
Natsuki Kishida, Kyosuke Matsumoto, Yuya Tanaka, Munetaka Akita, Hidehiro Sakurai, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142 ( 21 ) 9599 - 9603 2020.5
Synthesis of a Black Dye with Absorption Capabilities Across the Visible-to-Near-Infrared Region: A MO-Mixing Approach via Heterometal Coordination of Expanded Porphyrinoid. Reviewed International journal
Yue Wang, Hiroto Kai, Masatoshi Ishida, Sabapathi Gokulnath, Shigeki Mori, Tomotaka Murayama, Atsuya Muranaka, Masanobu Uchiyama, Yuhsuke Yasutake, Susumu Fukatsu, Yusuke Notsuka, Yoshihisa Yamaoka, Mamiko Hanafusa, Michito Yoshizawa, Gakhyun Kim, Dongho Kim, Hiroyuki Furuta
Journal of the American Chemical Society 142 ( 14 ) 6807 - 6813 2020.4
Kenta Ito, Tomoya Nishioka, Munetaka Akita, Akiyoshi Kuzume, Kimihisa Yamamoto, Michito Yoshizawa
Chemical Science 11 ( 26 ) 6752 - 6757 2020
Takahiro Tsutsui, Lorenzo Catti, Kenji Yoza, Michito Yoshizawa
Chemical Science 11 ( 31 ) 8145 - 8150 2020
A Redox-Active Heterocyclic Capsule: Radical Generation, Oxygenation, and Guest Uptake/Release. Reviewed International journal
Yoshiyuki Satoh, Lorenzo Catti, Munetaka Akita, Michito Yoshizawa
Journal of the American Chemical Society 141 ( 31 ) 12268 - 12273 2019.8
A Peanut-Shaped Polyaromatic Capsule: Solvent-Dependent Transformation and Electronic Properties of a Non-Contacted Fullerene Dimer Reviewed
Kyosuke Matsumoto, Shunsuke Kusaba, Yuya Tanaka, Yoshihisa Sei, Munetaka Akita, Kazushi Aritani, Masa-aki Haga, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 ( 25 ) 8463 - 8467 2019.6
A Polyaromatic Gemini Amphiphile That Assembles into a Well-Defined Aromatic Micelle with Higher Stability and Host Functions Reviewed
Tomoya Nishioka, Kiyonori Kuroda, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 ( 20 ) 6579 - 6583 2019.5
Luminescence tuning with excellent colour homogeneity and steadiness using fluorescent molecular liquids Reviewed
Fengniu Lu, Keita Hagiwara, Michito Yoshizawa, Kazuhiko Nagura, Shinsuke Ishihara, Takashi Nakanishi
JOURNAL OF MATERIALS CHEMISTRY C 7 ( 9 ) 2577 - 2582 2019.3
Open versus Closed Polyaromatic Nanocavity: Enhanced Host Abilities toward Large Dyes and Pigments Reviewed
Takahiro Tsutsui, Shunsuke Kusaba, Masahiro Yamashina, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 25 ( 17 ) 4320 - 4324 2019.3
A Pentacene-based Nanotube Displaying Enriched Electrochemical and Photochemical Activities Reviewed
Kiyonori Kuroda, Kohei Yazaki, Yuya Tanaka, Munetaka Akita, Hayato Sakai, Taku Hasobe, Nikolai V. Tkachenko, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 ( 4 ) 1115 - 1119 2019.1
A Supramolecular Approach to the Preparation of Nanographene Adlayers Using Water‐Soluble Molecular Capsules
Sakura Origuchi, Mai Kishimoto, Michito Yoshizawa, Soichiro Yoshimoto
Angewandte Chemie 130 ( 47 ) 15707 - 15711 2018.11
A Supramolecular Approach to the Preparation of Nanographene Adlayers Using Water-Soluble Molecular Capsules Reviewed
Sakura Origuchi, Mai Kishimoto, Michito Yoshizawa, Soichiro Yoshimoto
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 ( 47 ) 15481 - 15485 2018.11
Cramming versus threading of long amphiphilic oligomers into a polyaromatic capsule Reviewed
Masahiro Yamashina, Shunsuke Kusaba, Munetaka Akita, Takashi Kikuchi, Michito Yoshizawa
NATURE COMMUNICATIONS 9 2018.10
Supercooling of functional alkyl- molecular liquids Reviewed
Fengniu Lu, Keumhee Jang, Izabela Osica, Keita Hagiwara, Michito Yoshizawa, Masashi Ishii, Yoshiaki Chino, Kazuchika Ohta, Kinga Ludwichowska, Krzysztof Jan Kurzydlowski, Shinsuke Ishihara, Takashi Nakanishi
CHEMICAL SCIENCE 9 ( 33 ) 2018.9
Polyaromatic molecular tubes: from strategic synthesis to host functions Reviewed
Kohei Yazaki, Lorenzo Catti, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 54 ( 26 ) 3195 - 3206 2018.4
Self-Assembly Process of a Pd2L4 Capsule: Steric Interactions between Neighboring Components Favor the Formation of Large Intermediates Reviewed
Shumpei Kai, Masanori Nakagawa, Tatsuo Kojima, Xin Li, Masahiro Yamashina, Michito Yoshizawa, Shuichi Hiraoka
CHEMISTRY-A EUROPEAN JOURNAL 24 ( 16 ) 3965 - 3969 2018.3
Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water Reviewed
Shunsuke Kusaba, Masahiro Yamashina, Munetaka Akita, Takashi Kikuchi, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 ( 14 ) 3706 - 3710 2018.3
Alkylation-, Heating-, and Doping-Induced Emission Enhancement of a Polyaromatic Tube in the Solid State Reviewed
Kiyonori Kuroda, Masafumi Otsuki, Kohei Yazaki, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 13 ( 5 ) 515 - 519 2018.3
Encapsulation-induced emission enhancement (EIEE) of Eu(III)-complexes by aromatic micelles in water Reviewed
Tomokuni Kai, Mai Kishimoto, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 54 ( 8 ) 956 - 959 2018.1
Aromatic Micelles as a New Class of Aqueous Molecular Flasks Reviewed
Kei Kondo, Jeremy K. Klosterman, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 23 ( 66 ) 16710 - 16721 2017.11
Side-Chain-Directed Dispersion of MoS2 Nanosheets by V-Shaped Polyaromatic Compounds Reviewed
Atsushi Matsumoto, Keisuke Jono, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 12 ( 22 ) 2889 - 2893 2017.11
A Truncated Molecular Star Reviewed
Soumyakanta Prusty, Kohei Yazaki, Michito Yoshizawa, Dillip Kumar Chand
CHEMISTRY-A EUROPEAN JOURNAL 23 ( 51 ) 12456 - 12461 2017.9
A Switchable Open/closed Polyaromatic Macrocycle that Shows Reversible Binding of Long Hydrophilic Molecules Reviewed
Kohei Kurihara, Kohei Yazaki, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56 ( 38 ) 11360 - 11364 2017.9
Polyaromatic molecular peanuts Reviewed
Kohei Yazaki, Munetaka Akita, Soumyakanta Prusty, Dillip Kumar Chand, Takashi Kikuchi, Hiroyasu Sato, Michito Yoshizawa
NATURE COMMUNICATIONS 8 2017.6
A Polyaromatic Molecular Clip That Enables the Binding of Planar, Tubular, and Dendritic Compounds Reviewed
Keisuke Jono, Akira Suzuki, Munetaka Akita, Ken Albrecht, Kimihisa Yamamoto, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56 ( 13 ) 3570 - 3574 2017.3
Coordination-driven Nanostructures with Polyaromatic Shells Reviewed
Michito Yoshizawa, Masahiro Yamashina
CHEMISTRY LETTERS 46 ( 2 ) 163 - 171 2017.2
A pH-responsive molecular capsule with an acridine shell: catch and release of large hydrophobic compounds Reviewed
Mai Kishimoto, Kei Kondo, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 53 ( 8 ) 1425 - 1428 2017.1
Local environment inside a novel aromatic micelle investigated by steady-state and femtosecond fluorescence spectroscopy of an encapsulated solvatochromic probe Reviewed
Matthew M. Sartin, Kei Kondo, Michito Yoshizawa, Satoshi Takeuchi, Tahei Tahara
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 19 ( 1 ) 757 - 765 2017.1
Polycationic-Shelled Capsular and Tubular Nanostructures and Their Anionic-Guest Binding Properties Reviewed
Kohei Yazaki, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 49 ) 17557 - 17561 2016.12
An M2L4 Molecular Capsule with a Redox Switchable Polyradical Shell Reviewed
Kohei Yazaki, Shogo Noda, Yuya Tanaka, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55 ( 48 ) 15031 - 15034 2016.11
Interface Engineering of Metal Oxides using Ammonium Anthracene in Inverted Organic Solar Cells Reviewed
Il Jeon, Sasa Zeijkovic, Kei Kondo, Michito Yoshizawa, Yutaka Matsuo
ACS APPLIED MATERIALS & INTERFACES 8 ( 44 ) 29866 - 29871 2016.11
Recognition of Multiple Methyl Groups on Aromatic Rings by a Polyaromatic Cavity Reviewed
Masahiro Yamashina, Sho Matsuno, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 40 ) 14147 - 14150 2016.9
M2L4 coordination capsules with tunable anticancer activity upon guest encapsulation Reviewed
Anife Ahmedova, Rositsa Mihaylova, Denitsa Momekova, Pavletta Shestakova, Silviya Stoykova, Joana Zaharieva, Masahiro Yamashina, Georgi Momekov, Munetaka Akita, Michito Yoshizawa
DALTON TRANSACTIONS 45 ( 33 ) 13214 - 13221 2016.9
Engineering Stacks of V-Shaped Polyaromatic Compounds with Alkyl Chains for Enhanced Emission in the Solid State Reviewed
Shoya Sekiguchi, Kei Kondo, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55 ( 24 ) 6906 - 6910 2016.6
Solubility Switching of Metallophthalocyanines and Their Larger Derivatives upon Encapsulation Reviewed
Kei Kondo, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 6 ) 1937 - 1940 2016.2
Anticancer Potencies of Pt-II- and Pd-II-linked M2L4 Coordination Capsules with Improved Selectivity Reviewed
Anife Ahmedova, Denitsa Momekova, Masahiro Yamashina, Pavletta Shestakova, Georgi Momekov, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 11 ( 4 ) 474 - 477 2016.2
Efficient Catalytic Epoxidation in Water by Axial N-Ligand-Free Mn-Porphyrins within a Micellar Capsule Reviewed
Takumi Omagari, Akira Suzuki, Munetaka Akita, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138 ( 2 ) 499 - 502 2016.1
A fluorescent molecular capsule with a flexible polyaromatic shell for the detection of monoterpene compounds in water Reviewed
Akira Suzuki, Kei Kondo, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 52 ( 15 ) 3151 - 3154 2016
Amphiphilic tribranched scaffolds with polyaromatic panels that wrap perylene stacks displaying unusual emissions Reviewed
Akira Suzuki, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 52 ( 65 ) 10024 - 10027 2016
A V-Shaped Polyaromatic Amphiphile: Solubilization of Various Nanocarbons in Water and Enhanced Photostability Reviewed
Kei Kondo, Munetaka Akita, Takafumi Nakagawa, Yutaka Matsuo, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 21 ( 36 ) 12741 - 12746 2015.9
Preparation of Highly Fluorescent Host-Guest Complexes with Tunable Color upon Encapsulation Reviewed
Masahiro Yamashina, Matthew M. Sartin, Yoshihisa Sei, Munetaka Akita, Satoshi Takeuchi, Tahei Tahara, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137 ( 29 ) 9266 - 9269 2015.7
Anisotropic Expansion of an M2L4 Coordination Capsule: Host Capability and Frame Rearrangement Reviewed
Masahiro Yamashina, Tsubasa Yuki, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 21 ( 11 ) 4200 - 4204 2015.3
Polyaromatic Nanocapsules Displaying Aggregation-Induced Enhanced Emissions in Water Reviewed
Yusuke Okazawa, Kei Kondo, Munetaka Akita, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137 ( 1 ) 98 - 101 2015.1
Polyaromatic molecular tubes with a subnanometer pore and the guest-induced emission enhancement behavior Reviewed
Keita Hagiwara, Masafumi Otsuki, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 51 ( 52 ) 10451 - 10454 2015
An aqueous molecular tube with polyaromatic frameworks capable of binding fluorescent dyes Reviewed
Keita Hagiwara, Munetaka Akita, Michito Yoshizawa
CHEMICAL SCIENCE 6 ( 1 ) 259 - 263 2015
Well-defined aqueous nanoassemblies from amphiphilic meta-terphenyls and their guest incorporation Reviewed
Yusuke Okazawa, Kei Kondo, Munetaka Akita, Michito Yoshizawa
CHEMICAL SCIENCE 6 ( 8 ) 5059 - 5062 2015
Micellar Polyaromatic Capsules: Enhanced Emissive Properties through Shell-Functionalization Reviewed
Kei Kondo, Akira Suzuki, Munetaka Akita, Michito Yoshizawa
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2014 ( 33 ) 7389 - 7394 2014.11
A polyaromatic molecular tube that binds long hydrocarbons with high selectivity Reviewed
Kohei Yazaki, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
NATURE COMMUNICATIONS 5 2014.10
Safe storage of radical initiators within a polyaromatic nanocapsule Reviewed
Masahiro Yamashina, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
NATURE COMMUNICATIONS 5 2014.8
A Solvato-Fluorochromic Macrocycle of Multiple Anthracene Fluorophores in Close Proximity Reviewed
Zhiou Li, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 9 ( 4 ) 1016 - 1019 2014.4
Selective Host-Guest Interactions of a Transformable Coordination Capsule/Tube with Fullerenes Reviewed
Norifumi Kishi, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53 ( 14 ) 3604 - 3607 2014.4
Aromatic micelles with anthracene shells
Kei Kondo, Michito Yoshizawa
Kobunshi 63 ( 4 ) 229 - 230 2014
Molecular architectures of multi-anthracene assemblies Reviewed
Michito Yoshizawa, Jeremy K. Klosterman
CHEMICAL SOCIETY REVIEWS 43 ( 6 ) 1885 - 1898 2014
Facile Catch and Release of Fullerenes Using a Photoresponsive Molecular Tube Reviewed
Norifumi Kishi, Munetaka Akita, Motoshi Kamiya, Shigehiko Hayashi, Hsiu-Fu Hsu, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135 ( 35 ) 12976 - 12979 2013.9
Atroposelective Self-Assembly of a Molecular Capsule from Amphiphilic Anthracene Trimers Reviewed
Akira Suzuki, Kei Kondo, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 ( 31 ) 8120 - 8123 2013.7
Nonvolatile liquid anthracenes for facile full-colour luminescence tuning at single blue-light excitation Reviewed
Sukumaran Santhosh Babu, Martin J. Hollamby, Junko Aimi, Hiroaki Ozawa, Akinori Saeki, Shu Seki, Kenji Kobayashi, Keita Hagiwara, Michito Yoshizawa, Helmuth Moehwald, Takashi Nakanishi
NATURE COMMUNICATIONS 4 2013.6
Wide-Ranging Host Capability of a Pd-II-Linked M2L4 Molecular Capsule with an Anthracene Shell Reviewed
Norifumi Kishi, Zhiou Li, Yoshihisa Sei, Munetaka Akita, Kenji Yoza, Jay S. Siegel, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 19 ( 20 ) 6313 - 6320 2013.5
A bowl-shaped organic host using bispyridine ligands: selective encapsulation of carbonyl guests in water Reviewed
Kohei Yazaki, Norifumi Kishi, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 49 ( 16 ) 1630 - 1632 2013
Micelle-like Molecular Capsules with Anthracene Shells as Photoactive Hosts Reviewed
Kei Kondo, Akira Suzuki, Munetaka Akita, Michito Yoshizawa
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 ( 8 ) 2308 - 2312 2013
Extended Fluorochromism of Anthracene Trimers with a meta-Substituted Triphenylamine or Triphenylphosphine Core Reviewed
Zhiou Li, Hiromi Ishizuka, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-AN ASIAN JOURNAL 7 ( 8 ) 1789 - 1794 2012.8
Isostructural M2L4 Molecular Capsules with Anthracene Shells: Synthesis, Crystal Structures, and Fluorescent Properties Reviewed
Zhiou Li, Norifumi Kishi, Kenji Yoza, Munetaka Akita, Michito Yoshizawa
CHEMISTRY-A EUROPEAN JOURNAL 18 ( 27 ) 8358 - 8365 2012.7
A tubular macrocycle from covalently linked anthracenes and meta-phenylene spacers Reviewed
Keita Hagiwara, Yoshihisa Sei, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 48 ( 62 ) 7678 - 7680 2012
An M2L4 Molecular Capsule with an Anthracene Shell: Encapsulation of Large Guests up to 1 nm Reviewed
Norifumi Kishi, Zhiou Li, Kenji Yoza, Munetaka Akita, Michito Yoshizawa
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133 ( 30 ) 11438 - 11441 2011.8
Highly fluorescent M2L4 molecular capsules with anthracene shells Reviewed
Zhiou Li, Norifumi Kishi, Kimiko Hasegawa, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS 47 ( 30 ) 8605 - 8607 2011
Tuning the Stability and Reactivity of Metal-bound Alkylperoxide by Remote Site Substitution of the Ligand Reviewed
Shiro Hikichi, Chiho Kobayashi, Michito Yoshizawa, Munetaka Akita
CHEMISTRY-AN ASIAN JOURNAL 5 ( 9 ) 2086 - 2092 2010.9
m x n Stacks of Discrete Aromatic Stacks in Solution Reviewed
Yoshihiro Yamauchi, Yuya Hanaoka, Michito Yoshizawa, Munetaka Akita, Takahiro Ichikawa, Masafumi Yoshio, Takashi Kato, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132 ( 28 ) 9555 - 9557 2010.7
Development of Unique Chemical Phenomena within Nanometer-Sized, Self-Assembled Coordination Hosts Reviewed
Michito Yoshizawa, Makoto Fujita
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 83 ( 6 ) 609 - 618 2010.6
Engineering Double to Quintuple Stacks of a Polarized Aromatic in Confined Cavities Reviewed
Yoshihiro Yamauchi, Michito Yoshizawa, Munetaka Akita, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132 ( 3 ) 960 - 966 2010.1
ON/OFF Red Emission from Azaporphine in a Coordination Cage in Water Reviewed
Kosuke Ono, Jeremy K. Klosterman, Michito Yoshizawa, Kentaro Sekiguchi, Tahei Tahara, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 35 ) 12526 - + 2009.9
Discrete stack of an odd number of polarized aromatic compounds revealing the importance of net vs. local dipoles Reviewed
Yoshihiro Yamauchi, Michito Yoshizawa, Munetaka Akita, Makoto Fujita
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 26 ) 10435 - 10437 2009.6
In Situ Spectroscopic, Electrochemical, and Theoretical Studies of the Photoinduced Host-Guest Electron Transfer that Precedes Unusual Host-Mediated Alkane Photooxidation Reviewed
Yuji Furutani, Hideki Kandori, Masaki Kawano, Koji Nakabayashi, Michito Yoshizawa, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 13 ) 4764 - 4768 2009.4
Minimal nucleotide duplex formation in water through enclathration in self-assembled hosts Reviewed
Tomohisa Sawada, Michito Yoshizawa, Sota Sato, Makoto Fujita
NATURE CHEMISTRY 1 ( 1 ) 53 - 56 2009.4
Spin Crossover by Encapsulation Reviewed
Kosuke Ono, Michito Yoshizawa, Munetaka Akita, Tatsuhisa Kato, Yoshihide Tsunobuchi, Shin-ichi Ohkoshi, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 8 ) 2782 - + 2009.3
Switchable trans-cis interconversion of an amphiphilic anthracene trimer Reviewed
Junji Iwasa, Kosuke Ono, Makoto Fujita, Munetaka Akita, Michito Yoshizawa
CHEMICAL COMMUNICATIONS ( 38 ) 5746 - 5748 2009
Functional Molecular Flasks: New Properties and Reactions within Discrete, Self-Assembled Hosts Reviewed
Michito Yoshizawa, Jeremy K. Klosterman, Makoto Fujita
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 ( 19 ) 3418 - 3438 2009
Engineering stacks of aromatic rings by the interpenetration of self-assembled coordination cages Reviewed
Yoshihiro Yamauchi, Michito Yoshizawa, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130 ( 18 ) 5832 - + 2008.5
Three-metal-center spin interactions through the intercalation of metal azaporphines and porphines into an organic pillared coordination box Reviewed
Kosuke Ono, Michito Yoshizawa, Tatsuhisa Kato, Makoto Fujita
CHEMICAL COMMUNICATIONS ( 20 ) 2328 - 2330 2008.5
New Properties and Reactions in Self-Assembled M6L4 Coordination Cages Reviewed
Makoto Fujita, Michito Yoshizawa
Modern Supramolecular Chemistry: Strategies for Macrocycle Synthesis 277 - 313 2008.2
Unusual [2+4] and [2+2] cycloadditions of arenes in the confined cavity of self-assembled cages Reviewed
Yuki Nishioka, Takumi Yamaguchi, Michito Yoshizawa, Makoto Fujita
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 ( 22 ) 7000 - + 2007.6
Chirality enrichment through the heterorecognition of enantiomers in an achiral coordination host Reviewed
Michito Yoshizawa, Masazumi Tamura, Makoto Fujita
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46 ( 21 ) 3874 - 3876 2007
Porphine dimeric assemblies in organic-pillared coordination cages Reviewed
Kosuke Ono, Michito Yoshizawa, Tatsuhisa Kato, Kentaro Watanabe, Makoto Fujita
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46 ( 11 ) 1803 - 1806 2007
Diels-alder in aqueous molecular hosts: Unusual regioselectivity and efficient catalysis Reviewed
Michito Yoshizawa, Masazumi Tamura, Makoto Fujita
Science 312 ( 5771 ) 251 - 254 2006.4
Control of molecular interactions by the hollow of coordination cages Reviewed
Victor Maurizot, Michito Yoshizawa, Masaki Kawano, Makoto Fujita
DALTON TRANSACTIONS ( 23 ) 2750 - 2756 2006
Side chain-directed complementary cis-coordination of two pyridines on Pd(II): Selective multicomponent assembly of square-, rectangular-, and trigonal prism-shaped molecules Reviewed
Michito Yoshizawa, Muneki Nagao, Kazuhisa Kumazawa, Makoto Fujita
Journal of Organometallic Chemistry 690 ( 23 ) 5383 - 5388 2005.11
Room-temperature and solution-state observation of the mixed-valence cation radical dimer of tetrathiafulvalene, [(TTF)2]+., within a self-assembled cage Reviewed
Michito Yoshizawa, Kazuhisa Kumazawa, Makoto Fujita
Journal of the American Chemical Society 127 ( 39 ) 13456 - 13457 2005.10
Selective enclathration of linear alkanols by a self-assembled coordination cage. Application to the catalytic wacker oxidation of ω-alkenols Reviewed
Michito Yoshizawa, Naoko Sato, Makoto Fujita
Chemistry Letters 34 ( 10 ) 1392 - 1393 2005.10
Metal-metal d-d interaction through the discrete stacking of mononuclear M(II) complexes (M = Pt, Pd, and Cu) within an organic-pillared coordination cage Reviewed
Michito Yoshizawa, Kosuke Ono, Kazuhisa Kumazawa, Tatsuhisa Kato, Makoto Fujita
Journal of the American Chemical Society 127 ( 31 ) 10800 - 10801 2005.8
Self-assembled coordination cage as a molecular flask Reviewed
Michito Yoshizawa, Makoto Fujita
Pure and Applied Chemistry 77 ( 7 ) 1107 - 1112 2005.7
An efficient ionization method of electrospray mass spectrometry: The development of an aromatic-cored matrix that wraps labile metal complexes through molecular recognition Reviewed
Kazuhisa Kumazawa, Michito Yoshizawa, Hong-Bo Liu, Yuko Kamikawa, Masaya Moriyama, Takashi Kato, Makoto Fujita
Chemistry - A European Journal 11 ( 8 ) 2519 - 2524 2005.4
Discrete stacking of large aromatic molecules within organic-pillared coordination cages Reviewed
Michito Yoshizawa, Junichi Nakagawa, Kazuhisa Kumazawa, Muneki Nagao, Masaki Kawano, Tomoji Ozeki, Makoto Fujita
Angewandte Chemie - International Edition 44 ( 12 ) 1810 - 1813 2005.3
Endohedral clusterization of ten water molecules into a "molecular ice" within the hydrophobic pocket of a self-assembled cage Reviewed
Michito Yoshizawa, Takahiro Kusukawa, Masaki Kawano, Takashi Ohhara, Ichiro Tanaka, Kazuo Kurihara, Nobuo Niimura, Makoto Fujita
Journal of the American Chemical Society 127 ( 9 ) 2798 - 2799 2005.3
New Chemical Phenomena within the Isolated Cavities of Self-Assembled Coordination Cages
FUJITA Makoto, YOSHIZAWA Michito
Kobunshi 54 ( 2 ) 58 - 62 2005.2
Cavity-induced spin-spin interaction between organic radicals within a self-assembled coordination cage Reviewed
Koji Nakabayashi, Masaki Kawano, Michito Yoshizawa, Shin-Ichi Ohkoshi, Makoto Fujita
Journal of the American Chemical Society 126 ( 51 ) 16694 - 16695 2004.12
A palladium(II)-clipped aromatic sandwich Reviewed
Kazuhisa Kumazawa, Yoshinori Yamanoi, Michito Yoshizawa, Takahiro Kusukawa, Makoto Fujita
Angewandte Chemie - International Edition 43 ( 44 ) 5936 - 5940 2004.11
Alkane oxidation via photochemical excitation of a self-assembled molecular cage Reviewed
Michito Yoshizawa, Sachiko Miyagi, Masaki Kawano, Katsuya Ishiguro, Makoto Fujita
Journal of the American Chemical Society 126 ( 30 ) 9172 - 9173 2004.8
AND/OR bimolecular recognition Reviewed
Michito Yoshizawa, Masazumi Tamura, Makoto Fujita
Journal of the American Chemical Society 126 ( 22 ) 6846 - 6847 2004.6
Phenyl trifluorovinyl sulfide: A radical acceptor for preparation of gem-difluoromethylene compounds Reviewed
Takashi Okano, Masayuki Chokai, Makiko Hiraishi, Michito Yoshizawa, Takahiro Kusukawa, Makoto Fujita
Tetrahedron 60 ( 18 ) 4031 - 4035 2004.4
Cavity-directed syntheses within self-assembled nano-space Reviewed
Michito Yoshizawa, Makoto Fujita
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 62 ( 5 ) 416 - 423 2004
Cavity-directed synthesis within a self-assembled coordination cage: Highly selective [2 + 2] cross-photodimerization of olefins Reviewed
Michito Yoshizawa, Yoshihisa Takeyama, Takashi Okano, Makoto Fujita
Journal of the American Chemical Society 125 ( 11 ) 3243 - 3247 2003.3
Side chain-directed assembly of triangular molecular panels into a tetrahedron vs. open cone Reviewed
M Yoshizawa, M Nagao, K Umemoto, K Biradha, M Fujita, S Sakamoto, K Yamaguchi
CHEMICAL COMMUNICATIONS ( 15 ) 1808 - 1809 2003
Multicomponent metal–ligand self-assembly
Wei-Yin Sun, Michito Yoshizawa, Takahiro Kusukawa, Makoto Fujita
Current Opinion in Chemical Biology 6 ( 6 ) 757 - 764 2002.12
Selective synthesis, characterization, and configurational flexibility of the coordinatively unsaturated metal center of half-sandwich type complexes with the less-hindered hydrotris(3, 5-dimethyl-4-X-1-pyrazolyl)borate ligands [Tp Me2,XM II(κ 2-O,O′-L)] (M = Ni, Co; L = NO 3, OAc; X = Me, H, Br) Reviewed
Shiro Hikichi, Yasuyuki Sasakura, Michito Yoshizawa, Yoshiko Ohzu, Yoshihiko Moro-oka, Munetaka Akita
Bulletin of the Chemical Society of Japan 75 ( 6 ) 1255 - 1262 2002.6
Cavity-directed, highly stereoselective [2+2] photodimerization of olefins within self-assembled coordination cages Reviewed
Michito Yoshizawa, Yoshihisa Takeyama, Takahiro Kusukawa, Makoto Fujita
Angewandte Chemie - International Edition 41 ( 8 ) 1347 - 1349 2002.4
Structural characterization and intramolecular aliphatic C-H oxidation ability of MIII(μ-O)2MIII complexes of Ni and Co with the hydrotris-(3,5-dialkyl-4-X-pyrazolyl)borate ligands TpMe2,X (X = Me, H, Br) and TpiPr2 Reviewed
Shiro Hikichi, Michito Yoshizawa, Yasuyuki Sasakura, Hidehito Komatsuzaki, Yoshihiko Moro-oka, Munetaka Akita
Chemistry - A European Journal 7 ( 23 ) 5012 - 5028 2001.12
Cavity-directed synthesis of labile silanol oligomers within self-assembled coordination cages Reviewed
M. Yoshizawa, T. Kusukawa, M. Fujita, S. Sakamoto, K. Yamaguchi
Journal of the American Chemical Society 123 ( 43 ) 10454 - 10459 2001.10
Characterization of Encapsulating Supramolecules by Using CSI-MS with lonization-Promoting Reagents Reviewed
Shigeru Sakamoto, Michito Yoshizawa, Takahiro Kusukawa, Makoto Fujita, Kentaro Yamaguchi
Organic Letters 3 ( 11 ) 1601 - 1604 2001.5
Probing guest geometry and dynamics through hostn - Guest interactions Reviewed
Takahiro Kusukawa, Michito Yoshizawa, Makoto Fujita
Angewandte Chemie - International Edition 40 ( 10 ) 1879 - 1884 2001.5
Molecular paneling via coordination
Makoto Fujita, Kazuhiko Umemoto, Michito Yoshizawa, Norifumi Fujita, Takahiro Kusukawa, Kumar Biradha
Chemical Communications ( 6 ) 509 - 518 2001
Michito Yoshizawa, Takahiro Kusukawa, Makoto Fujita, Kentaro Yamaguchi
Journal of the American Chemical Society 122 ( 26 ) 6311 - 6312 2000.7
Oxygenation of saturated hydrocarbyl groups in the dinuclear Ni(III) bis(μ-oxo) complexes with the hydrotris(pyrazolyl)borate ligands TpR (R = Me3 and Pri2) Reviewed
Shiro Hikichi, Michito Yoshizawa, Yasuyuki Sasakura, Hidehito Komatsuzaki, Munetaka Akita, Yoshihiko Moro-oka
Chemistry Letters ( 9 ) 979 - 980 1999
Tail-to-Tail Dimerization of Acrylonitrile Catalyzed by Low-Valent Ruthenium Complexes Reviewed
Atsushi Fukuoka, Takeyuki Nagano, Shuichi Furuta, Michito Yoshizawa, Masafumi Hirano, Sanshiro Komiya
Bulletin of the Chemical Society of Japan 71 ( 6 ) 1409 - 1415 1998
Recent Developments in Supramolecular Anthracene Assemblies
19 ( 4 ) 182 - 191 2015
Creation of Three-Dimensional Nanostructures with Anthracene Shells
Keita Hagiwara, Michito Yoshizawa
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 72 ( 6 ) 692 - 701 2014.6
空隙を有する超分子イオン結晶の２次元単分子膜形成とその結晶成長
Grant number：24K21719 2024.6 - 2026.3
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽)
吉本 惣一郎, 平田 海斗, 吉沢 道人, 福間 剛士
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
芳香環カプセルのクロスリンクによる多空間固体材料の開発
Grant number：23K17913 2023.6 - 2025.3
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽)
吉沢 道人
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
本年度は、有限な「芳香環カプセル」の優れた分子捕捉能を維持しつつ、それらの金属イオンによるクロスリンクで、無限の多空間骨格を有する「芳香環カプセル固体」の作製に挑戦した。その結果、カプセル外部に金属配位点を有する外面配位型のM2L4組成の芳香環カプセルの構築と外面配位型の芳香環カプセルの金属配位結合によるクロスリンクを達成した。まず、湾曲型３座ピリジル配位子は根岸・鈴木-宮浦カップリング反応を含む計３段階の反応で得た。次に、外面配位型のM2L4組成の芳香環カプセルの合成は、この新規配位子と金属イオンを加熱混合することで達成した。それらの構造は、NMRおよびMSで明らかにした。さらに、M2L4組成のクロスリンク芳香環カプセルの構築は、得られた外面配位型芳香環カプセル溶液に対して、2当量の金属イオンを加え加熱混合することで達成した。このクロスリンク芳香環カプセルは金属イオンの種類に依存して、シート状構造および粒子状構造を取ることをAFMで明らかにした。
新しい生体超分子S8環八超硫黄の発見と生理機能解明
Grant number：22K19397 2022.6 - 2024.3
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 挑戦的研究(萌芽)
赤池 孝章, 吉沢 道人
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
生体空間機能を志向した芳香環ナノ空間の開発
Grant number：22H00348 2022.4 - 2026.3
日本学術振興会 科学研究費助成事業 基盤研究(A)
吉沢 道人
Grant amount：\42640000 （ Direct Cost: \32800000 、 Indirect Cost：\9840000 ）
優れた捕捉能と応答能を有する芳香環オリゴマーミセルの創製
Grant number：21K18951 2021.7 - 2023.3
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽)
吉沢 道人
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
本年度は、高い集合安定性の芳香環オリゴマーミセルの構築を行った。２つのアントラセン環パネルを有する湾曲型両親媒性分子AAは、水中で５分子から成る芳香環ミセルを形成する。しかしながら、その希釈に対する安定性は中程度（臨界ミセル濃度（CMC）＝１mM）で、高温条件で容易に解離する。そこで本研究では、超高希釈と超高温で安定な芳香環ミセルの構築に挑戦した。その戦略として、AA を直線型に「連結」することで「両親媒性オリゴマー」を合成した。実際には、湾曲型両親媒性分子AA の親水基をオリゴエチレングリコール鎖で連結した。連結鎖はパネルの集合を阻害しないため、目的の芳香環オリゴマーミセルの構築が期待できる。まず、湾曲型両親媒性分子の３量体 AT の合成と水中での集合体を達成した。次に、集合体の詳細な構造（DLS, AFM解析など）と集合安定性（NMR, UV-vis, 蛍光, ITC解析など）を解明した。
Construction and Precise Control of the Highly Functionalized Assembly for Giant Nanographenes using "Molecular Container" Method
Grant number：19H02560 2019.4 - 2022.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Yoshimoto Soichiro
Grant amount：\17680000 （ Direct Cost: \13600000 、 Indirect Cost：\4080000 ）
We have established a methodology for encapsulating water-insoluble nanographenes in water-soluble micellar capsules and transporting the nanographenes to the surface of gold and/or graphite. Particularly, we succeeded to obtain the molecular resolution scanning tunneling microscopy (STM) images of the triangle-shaped C96H30 and the three-leafed C150H42, and hexagonal C222H42. We also succeeded to find the structural changes of the ovalene adlayer on Au(111) at the electrochemical interface and one of the thiolate molecules into the gap site, by the so-called “molecular planting”. In addition to the results related to the adsorption and organization of hydrophobic molecules, we also focused on metal complex molecules such as iron phthalocyanine (FePc). The FePcs-encapsulating capsules exhibit the function as a “nanoreactor” that promotes the oxygen reduction reaction (ORR).
金属架橋カプセルの構造／機能の異方的拡張
Grant number：19H04566 2019.4 - 2021.3
日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型)
吉沢 道人
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
本研究の目的は、「多環芳香族ナノ空間」を有する金属架橋カプセルを基盤として、その有機配位子に異種の多環芳香族パネルを導入することで、新たな『異方性ナノ空間』を精密構築することである。また、その多環芳香族骨格に囲まれた特異ナノ空間の高い分子内包能を活用した、新空間機能と新空間材料の創出を目指す。これら目的の達成により、本領域研究が目指す独創的な「空間アシンメトリー」の化学の推進に貢献する。これまでに申請者は、アントラセン環を含む湾曲型の有機配位子と金属イオンの錯形成により、多環芳香族パネルに囲まれた約１ nmの孤立空間を有する金属架橋カプセルの構築を達成した。この孤立空間では、π-スタッキング・CH-π相互作用と疎水効果が三次元的および共同的に働くことで、特異機能が発現した。これらの知見を活かして、本研究では金属架橋カプセルの異方性展開を図った。
「研究成果１：アニソトロピック型ナノ空間の異性化制御」本年度は、２つのナフタレン環を持つ新規な二座配位子を設計および合成した。これらと金属イオンの錯形成で、最大で４２個の異性体を持つアニソトロピック型の金属架橋ケージを構築した。この金属架橋ケージにおいて、内包分子の種類に応じて異性化を制御することに成功した。具体的には、フラーレンC60を内包することで、１つの異性体構造に収束することをNMRや結晶構造解析で明らかにした。
「研究成果２：扁球型ナノ空間によるボウル反転制御」本年度は、金属架橋カプセルの異方的な空間縮小を達成した。２つのアントラセン環をオルトフェニレン鎖で連結した湾曲型配位子を活用して、扁球型の金属架橋カプセルの構築に成功した。また、空間機能を解明した。具体的には、温度可変のNMR解析から、ボウル型のスマネンを１分子内包することでその圧縮効果により、ボウル反転運動の顕著な加速を達成した。
Selective Recognition of Biomolecules by Polyaromatic Nanopockets
Grant number：18H01990 2018.4 - 2021.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Yoshizawa Michito
Grant amount：\17550000 （ Direct Cost: \13500000 、 Indirect Cost：\4050000 ）
For the development of selective sensing systems for various biomolecules in water, we designed and prepared polyaromatic nanopockets inspired by biological protein nanopockets. Using the synthetic nanopocket, we succeeded in the selective binding of male hormones such as testosterone from a mixture of male and female hormones in water. In addition, selective recognition of fatty acids with multiple unsaturated units was also achieved by the nanopocket.
多環芳香族パネルを有する動的ケージの構築とその高次フラーレンの選択的分離
Grant number：17F17816 2017.11 - 2020.3
日本学術振興会 科学研究費助成事業 特別研究員奨励費
吉沢 道人, CATTI LORENZO, Catti Lorenzo
Grant amount：\2200000 （ Direct Cost: \2200000 ）
本研究では、多環芳香族パネルを有する動的ケージを新規に構築するとともに、その機能の開拓を行う。まず、配位結合やパイスタッキング相互作用、動的共有結合などを利用して、新規な動的ケージの構築に挑戦する。例えば、湾曲型の多環芳香族パネルにホルミル基を導入した前駆体を合成し、それとアミノ基を持つ架橋分子との脱水縮合で、狙いとする動的ケージを構築する。また、種々の多環芳香族パネルを含む分子パーツの自己組織化で、空間性質の異なる分子ケージも構築する。次に、得られた動的分子ケージを使って、特異な分子内包機能を開拓する。特に、難溶性で分離が困難な高次フラーレンの選択的な内包に挑戦する。さらに、水中で機能する外部刺激応答性の分子ケージやカプセルの開発にも挑戦する。
本年度は、外部刺激に応答する新規な動的カプセルの構築と機能開拓を検討した。具体的には、湾曲型の多環芳香族骨格に酸化還元活性なフェノチアジン環を導入することで、新たなV型両親媒性分子を合成した。それらは水中で、疎水効果とパイスタッキング相互作用を駆動力に自己組織化することで、新たな球状の動的カプセルを形成した。その三次元構造をNMR, DLS, AFM 分析で解明した。また、動的カプセルの分光学的性質や電気化学的性質を調査した。その結果、酸化によりラジカルカプセルを可逆的に生成できることが判明した。さらに、種々のゲスト分子の内包と外部刺激により放出を達成した。水中で利用できる新規な動的カプセルを構築すると共に、その特異機能を明らかにした。
金属架橋カプセルの異方性機能展開
Grant number：17H05359 2017.4 - 2019.3
日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型)
吉沢 道人
Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）
本研究の目的は、我々がこれまでに開発した高い分子内包能の「多環芳香族ナノ空間」を有する金属架橋カプセルを基盤として、これと「異方性（アシンメトリー）」を組み合わせることで、新たな『 異方性ナノ空間の化学 』を創出する。具体的な研究課題として、対称性の高いナノ空間を活用して、非対称性ゲスト分子を内包することで、選択的に異方性ホスト-ゲスト錯体を作製する。また、新規な非対称性ナノ空間を配位結合を使って構築し、その空間が持つ特異物性や相互作用などを解明する。本研究領域のA03班において、他の班との共同研究により、「溶液系」と「多環芳香族骨格」と「孤立ナノ空間」を特徴とした独創的な「空間アシンメトリー」の化学の推進に貢献する。本年度は、芳香環に囲まれたナノ空間が、水中、瞬時にかつ100%の収率で、親水性で非対称性なオリゴ乳酸オリゴを内包できることを見出した。また、結晶構造解析や等温カロリメトリーでの詳細なメカニズムの検証から、内包体は多点の分子間相互作用に基づく負のエンタルピー変化により、水中で安定化することが明らかになった。さらに、両親媒性で対称性のオリゴエチレンオキシドが水中・室温で、瞬時かつ定量的に、金属架橋カプセルと結合することを見出した。結合様式は基質の長さに依存し、約3 nmまでのオリゴエチレンオキシドはカプセル内部に包み込まれ、それより長いオリゴエチレンオキシドはカプセル骨格を貫いて結合した。詳細な熱量分析から、この前例のない貫通型ナノ構造体の形成は、カプセル内面とひも状分子の多点相互作用が駆動力と判明した。水中での芳香環ナノポケットと生体関連分子の相互作用を明らかにした。新たな「多環芳香族ナノ空間」の機能を開拓した。
Selective Recognition of Biomolecules by Molecular Capsules
Grant number：16K13947 2016.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
Yoshizawa Michito
Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）
Selective recognition of saccharides by artificial receptors in water is a challenging goal due to their strong hydrophilicities and complex molecular structures with subtle regio- and stereochemical differences. Here we report the selective and efficient encapsulation of D-sucrose within a coordination-driven molecular capsule from natural saccharide mixtures in water (~100% selectivity and >85% yield). Unlike previous artificial receptors and natural receptors that rely on multiple hydrogen-bonding interactions, theoretical calculations and control experiments indicate that the observed unique selectivity arises frommultiple CH-pi interactions between the sucrose hydrocarbon backbone and the shape-complementary polyaromatic cavity (~1 nm in diameter) of the capsule.
Development of New Polyaromatic Nanocapsules with Photofunctions
Grant number：26288033 2014.4 - 2017.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Yoshizawa Michito
Grant amount：\16900000 （ Direct Cost: \13000000 、 Indirect Cost：\3900000 ）
The development of new fluorescent molecules and molecular assemblies is of importance for the preparation of unique photofunctional materials. In this work, we succeeded in the quantitative formation of new polyaromatic nanocapsules with fluorescent properties in water from V-shaped amphiphilic compounds with various polyaromatic rings. The nanocapsule could encapsulate a wide range of water-insoluble molecules (e.g., fullerenes, carbon nanotubes, and phthalocyanines) in the hydrophobic cavity to give aqueous host-guest nanocomposites in water. In addition, host-guest nanocomposites containing fluorescent dyes (e.g., DCM and Nile red) display unique photofunctional properties in solution and in the solid state.
Stabilization of Radical Initiators within a Metal-linked Molecular Capsule
Grant number：26620041 2014.4 - 2016.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
Yoshizawa Michito
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
AIBN and its derivatives are useful reagents for polymer and organic syntheses that generate radical species on stimuli by light or heat. These radical initiators are unstable so that they should be kept in the dark at low temperature to avoid photochemical and thermal decomposition. In this work, we demonstrated the quantitative encapsulation of the radical initiators by a metal-linked molecular capsule in aqueous solutions. We also revealed the remarkable stability of the initiators toward light and heat in the cavity shielded by the polyaromatic capsule shell. The stabilized initiators could be utilized for the radical polymerization of olefins on spontaneous release of the initiators from the capsule.
Development of Photo-Responsive Supramolecular Materials with Precise Molecular Design
Grant number：25104011 2013.6 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
NAKANISHI TAKASHI, ISHIHARA Shinsuke
Grant amount：\56680000 （ Direct Cost: \43600000 、 Indirect Cost：\13080000 ）
For studying the “Function of Soft Molecular Systems” in one of the “Creation” research groups, we have approached from organic and materials chemistry by the concerted use of “theory” and advanced spectroscopic “experiments”. Our target systems are mainly photo responsive supramolecular materials at different length scale from discrete capsule-like self-assemblies at nanometer scale to molecular liquid materials at bulk scale. The optical information/properties were positively utilized for understanding the formation mechanism of assemblies and the unique function.
We have achieved (i) multifunctional molecular capsules and tubes, and (ii) optoelectronically-active molecular liquids. And many collaborations with theory and advanced experiments were successfully conducted in the KAKENHI project.
π電子系空間を基盤とした機能性分子集積素子の開発
Grant number：21108011 2009 - 2013
日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型)
吉沢 道人
Grant amount：\28210000 （ Direct Cost: \21700000 、 Indirect Cost：\6510000 ）
比較的大きな芳香族分子は非局在化した複数のπ電子を有するため、興味深い分光学的性質を示す。これらを集積したカラム状構造体は、π共役系の三次元的な拡張により、分子単独では観測されない特異な物性を発現する。我々は最近、有機多座配位子と金属イオンの自己組織化により、芳香環の7重集積体を簡便かつ精密に組み上げることに成功した(M.Yoshizawa et al.,JACS,2008,130,5832-5833)。この7重集積体は、上下2つの芳香族分子を有する2つの箱型分子が3次元的にインターロックして、その間に3つの芳香族分子がインターカレーションした構造である。そこで本年度は、7重集積体の"側面官能基化"による1次元自己組織化を達成したので報告する。
まず、芳香環7重集積体の構成成分である、官能基を導入した新規ピラー状配位子は、Diels-Alder反応により効率良く合成した。次に、合成したピラー状配位子、パネル状配位子、シス位をエチレンジアミンで保護したパラジウム錯体(4:6:12の比率)を過剰量のトリフェニレン存在下、水中で混合することにより、目的とする側面を官能基化した7重集積体を定量的に構築することに成功した。この構造は、詳細なNMRおよびX線結晶構造解析により決定した。その結晶構造では、7枚の芳香環が約3.5Aの面間距離で集積していることから、効果的なπ-π相互作用が働いていることが示された。^1HNMRにおいて芳香環に由来するシグナルは、低濃度でシャープに観測されるのに対して、高濃度では顕著にブロード化した。また、DOSYによる拡散係数の値も大きく変化した。さらに、7重集積体はリオトロピック液晶性を発現した。以上のことから、側面官能基化した7重集積体は、高濃度で分子間スタッキングして、1次元方向に自己集積することが明らかになった。
孤立ナノ空間に形成された水クラスターの水素結合ダイナミクス解析
Grant number：20050013 2008 - 2009
日本学術振興会 科学研究費助成事業 特定領域研究
古谷 祐詞, 古沢 道人
Grant amount：\3500000 （ Direct Cost: \3500000 ）
「かご状有機金属錯体」は、自己組織化により特異なナノメートルサイズの疎水的空間を内部に形成し、様々な化学反応の場を提供する「分子フラスコ」としてはたらく。本研究では、この特異なナノ空間中における水クラスターおよびアダマンタンの光化学反応メカニズムを赤外および可視分光法で比較解析し、ナノ空間に束縛された水クラスターの水素結合ダイナミクスを明らかにすることを最終的な目的としている。
これまでにアダマンタンを内包したかご状錯体に対する低温赤外分光解析により、光電子移動によるアダマンタンおよびかご状錯体の構造変化を検出した(Y.Furutani et al., J.Am.Chem.Soc., 2009)。このような構造変化を実時間で捉えるために、2009年3月に異動した分子科学研究所において、新たに時間分解赤外分光計測系を立ち上げた。光受容タンパク質であるバクテリオロドプシンについては、内部結合水のO-H, O-D伸縮振動の変化を含む4000-900cm^<-1>領域での計測を12.5マイクロ秒の時間分解能で実現した。また、アダマンタンからかご状錯体への光誘起電子移動に伴う可視吸収変化を実時間で捉えるために、東工大資源研の藤井正明教授、酒井誠准教授、井上圭一特任助教(現、名古屋工業大学助教)に協力頂いて、266nm紫外光励起、500-750nm可視光プローブのピコ秒過渡吸収計測を行った(A01班内共同研究)。さらに、A03班の須藤雄気准教授との共同研究として、光センサー蛋白質の分子機構について赤外分光計測を行い、3件の論文を発表した。以上の研究により、ナノ空間に束縛された水クラスターの水素結合ダイナミクスだけでなく、蛋白質場での特異な光誘起構造変化による情報伝達機構などについても様々な知見を得た。
Spin-spin interactions of metal-complexes within organic-pillared coordination boxes
Grant number：20750042 2008 - 2009
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
YOSHIZAWA Michito
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(II)-azaporphine/porphine cartridges (M=Cu(II), Pd(II) or Co(II)), where the metal arrays show unique spin interactions in ESR : in particular, Δms=3 for the Cu-Cu-Cu array.
自己組織化錯体空間を利用したπ共役系分子の有限集積と機能発現
Grant number：18685012 2006 - 2007
日本学術振興会 科学研究費助成事業 若手研究(A)
吉沢 道人
Grant amount：\10140000 （ Direct Cost: \7800000 、 Indirect Cost：\2340000 ）
ボトムアップ型の機能性材料開発においては、新しい性質を有する分子の合成とともに、それらをナノメートルレベルで精密かつ簡便に「配置する」技術が重要な鍵を握る。前者は、従来の合成化学的な手法を駆使することで、これまでに大きな発展を遂げてきた。それに対して後者は、1つ1つの分子をつかんで置くことのできない私たちにとって、現在もなお困難な課題である。そこで本研究では、配位結合を駆動力とした有機配位子と金属イオンの自己組織化に着目し、この仕組みをπ共役系分子の有限集積に活用することで、効率的なπ共役系分子の高次有限集積化を達成し、その集積体を用いた新奇な物性の開拓を検討した。平面状金属錯体の代表格である、巨大な色素分子、ポルフィリン類は様々な金属を導入できることから、その高次集積構造に興味が集まっている。しかしながら、3分子以上のポルフィリン金属錯体をカラム状に集積し、複数の金属間で相互作用を誘起させた例はほとんどない。そこで本研究では、伸長したピラー状分子を用い、内部に3分子集積可能な箱型骨格を利用して、3重金属集積体の構築を検討した。その結果、ポルフィリン金属錯体とその類縁体であるアザポルフィリン金属錯体を組み合わせることで、同種の金属錯体の三重集積化だけでなく、2種類の金属錯体を交互集積することに成功した。具体的には、銅-銅-銅、銅-パラジウム-銅および銅-コバルト-銅からなる三重金属集積体を組み上げた。そこで、集積された3つの金属はお互いにコミュニケーションしているか?いないのか?を明らかにするため、電子スピン共鳴を測定した。その結果、銅錯体の三重集積体では、不対電子(=スピン)を持つ3つの銅間でのスピン-スピン相互作用に由来するΔm_s-1〜3シグナルを初めて観測することに成功した。
自己組織化孤立ナノ空間を利用した新反応・新現象の創出
Grant number：16750071 2004 - 2005
日本学術振興会 科学研究費助成事業 若手研究(B)
吉沢 道人
Grant amount：\3700000 （ Direct Cost: \3700000 ）
ある種の芳香族分子は集積することで、分子単独では見られない特異な性質を示すことが知られている。例えば、芳香族分子が2分子集積した電荷移動錯体や無限集積した液晶などが、有機伝導体や動的機能性材料として盛んに研究されている。しかしながら、その中間に位置する芳香族分子の有限な集積体は、集積する分子の数や種類、順序に応じた特異な物性発現が期待されるにも関わらず、その有効な合成手段すら見出されていない。そこで本研究では、配位結合を駆動力とした有機配位子と金属イオンの自己組織化に着目し、この仕組みをπ共役系分子の有限集積に活用することで、効率的なπ共役系分子の高次有限集積化を達成し、その集積体を用いた新奇な物性・反応性の開拓を検討した。まず、合理設計した有機配位子と金属イオンの自己組織化により、必要な成分を混合するだけで狙いとする有限集積体を一義的に組み上げる。その合成戦略として、集積するn枚のπ共役系分子に対して、その上下に2枚のパネル状配位子を配置し、その距離に応じたピラー型配位子を用意し、それらを金属イオンで繋ぐことで有限集積体が構築できると考えた。実際、上述の合成戦略で4重の集積体が一義的に合成できることを見出した。ここでは、平面状のピリジン三座配位子、直線状のビピリジン配位子、シス位をエチレンジアミンで保護したパラジウム錯体、そしてπ共役系分子としてピレンを水溶液中で混合することで、かご型の4重集積体が定量的に生成した。その構造は、X線結晶構造解析によっても明らかにした。また、内部集積した2枚のピレンは、かご型骨格から容易に抽出でき、再び、他の芳香族分子を2分子集積できることを明らかにした。
Programmed Molecular Self-assembly Utilizing Transition Metals : Synthesis and Function of Nano-scale Molecular Materials
Grant number：14103014 2002 - 2006
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)
FUJITA Makoto, KAWANO Masaki, YOSHIZAWA Michito, SATO Sota
Grant amount：\113620000 （ Direct Cost: \87400000 、 Indirect Cost：\26220000 ）
In this project, we have focused on the synthesis and function of nano-scale molecular materials by programmed molecular self-assembly utilizing transition metals. Here we summarize our research results that are divided into the five topics. (1)Self-assembly of endo-functionalized molecular spheres : we succeeded in the formation of a liquid-like fluorous droplet, composed of 24 perfluoroalkyl chains confined in the interior of a 5-nanometer-sized, roughly spherical shell. The structures were spontaneously assembled in solution from 12 palladium ions and 24 bridging ligands. (2)Photo-switchable molecular catenate : We achieved a precise, clean molecular lock that operates by light. Since the inert Pt(II)-py bond is considerably labialized upon UV irradiation, we demonstrated the photo-switchable molecular lock by the one-way catenation of coordination rings. (3)Selective recognition and folding of oligopeptides by self-assembled hosts : We anticipated that the large hydrophobic cavity of self-assembled hosts could replace the protein scaffolds and stabilize the secondary structures of oligopeptides. (4)Unusual chemical reactions within self-assembled hosts : We found that an aqueous self-assembled cage induces highly unusual regioselectivity in the Diels-Alder reactions of anthracene and phthalimide molecules, promoting reaction at a terminal ring. (5)Direct crystallographic observation of unstable transition species within self-assembled hosts : We succeeded in the in situ crystallographic observation of a coordinatively unsaturated metal complex within a self-assembled coordination cage.
