Updated on 2025/10/07

写真a

 
KATO AKIRA
 
Organization
School of Life Science and Technology Associate Professor
Title
Associate Professor
External link

News & Topics

  • The Evolutionary Timeline of Diminished Boric Acid and Urea Transportation in Aquaporin 10

    2023/12/27

    Languages： English

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    Aquaporin (Aqp) 10 water channels in humans allow the free passage of water, glycerol, urea, and boric acid across cells. However, Aqp10.2b in pufferfishes allows only the passage of water and gl

  • Aqp10タンパク質の尿素・ホウ酸輸送活性の減弱が生じた進化上のタイミングを同定 アクアグリセロポリンの基質選択メカニズムの解明への貢献に期待

    2023/12/15

    Languages： Japanese

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    要点-肉鰭類と条鰭類で異なるAqp10タンパク質の尿素・ホウ酸輸送活性を解析。-条鰭類のAqp10.2が進化の過程で尿素・ホウ酸輸送活性を減弱させていたことを発見。-栄養輸送などに寄与するアクアグリセロポリンの基質選択メカニズム解明への貢献に期待。概

  • 魚類に特有なNa+-Cl- 共輸送体2遺伝子を 哺乳動物などでも発見

    2023/02/06

    Languages： Japanese

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    要点 魚類に特有とされてきたNa+-Cl- 共輸送体2をコードする遺伝子（NCC2遺伝子）が、一部の哺乳動物や非鳥類型爬虫類、両生類にも存在することを発見。 ヒト・マウスを含む大部分の哺乳動物、鳥類、一部の真骨魚類では、NCC2遺伝子が偽遺伝子化・欠損していることを確認。 NCC2遺伝子の偽遺伝子化や欠損が脊椎動物のさまざまな系統で独立に起きたことを示唆。 概要東京工業大学 生命理工学院

  • New Study Sheds Light on Boric Acid Transport and Excretion in Marine Fish

    2022/12/14

    Languages： English

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    Seawater is known to contain a significant concentration of boric acid, which can be toxic and deadly to living systems. As such, fish living in marine habitats need to be able to excrete boric acid

  • 魚類が「ホウ酸」を体外に排出して 海水に適応するメカニズムを解明 持続可能な海水魚の養殖等への応用を期待

    2022/12/14

    Languages： Japanese

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    要点 海水魚が飲み込んだ海水に含まれるホウ酸は腸で吸収され、腎臓で尿中に濃縮・排出されることを発見。ホウ酸は過剰摂取・蓄積により毒性を示す。 動物の体内で働く起電性のホウ酸輸送体「Slc4a11A」を同定し、ホウ酸排出の分子メカニズムを明らかに。 海洋生物の環境適応機構の解明や、持続可能な海水魚の養殖等への応用に寄与することを期待。 概要東京工業大学 生命理工学院 生命理工学系の加藤明准

  • 魚が淡水中のわずかな栄養素を取り込む機構を解明 －ナトリウムイオンとアンモニウムイオンの交換輸送体を特定－

    2014/02/26

    Languages： Japanese

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    【要点】○ 淡水魚はえらを介して淡水中のわずかなナトリウムイオンを栄養素として取り込む○ ナトリウムイオン吸収はアンモニウムイオン排出と交換で行われ、今回、その交換輸送を担うタンパク質（交換輸送体）を特定○ 魚類の淡水適応機構の解明、ヒト腎臓のアンモニア排出機序理解の手がかりになる【概要】東京工業大学とメイヨー医科大学（米・ミネソタ州）の研究グループは、淡水魚のえらで働くNa+/NH4+ 交換輸送体を初めて特定し、その活性を明らかにしました。淡水魚のえらは淡水中のわずかなイオンを栄養素として吸収することができます。淡水からのNa+ 吸収はNH4+ 排出と交換で行われるという説が70年前に提唱されましたが、その分子実体は特定されておらず、長い間専門家の間で議論されてきました。

  • Absorbing sodium from freshwater in exchange with waste - Identification of a Na+/NH4+ exchanger in teleost gill -

    2014/02/26

    Languages： English

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    Freshwater teleosts absorb Na+ from low-salt environments in the body as a nutrient.Na+ is considered to be absorbed in exchange with ammonium ions. Here, we identified the molecule that mediates Na+/NH4+ exchange. This study will contribute to elucidate the mechanism by which teleost fish adapt to freshwater, and may provide clues for understanding the acid waste system of the human kidney.SummaryA collaborative team from the Tokyo Institute of Technology and Mayo Clinic identified a Na+/NH4+ exchanger for the first time in the gill of freshwater fish and characterized its activity. Freshwater fish absorb Na+ from low-salt environments from the gill. Approximately 70 years ago, Na+ was suggested to be absorbed in exchange with NH4+; however, ...

  • 体内の余分なマグネシウムを尿中に排出する新たな経路を特定

    2013/06/21

    Languages： Japanese

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    ○　海水魚は海水に含まれるマグネシウムの過剰摂取から身を守るために，マグネシウムを尿中に捨てます。○　マグネシウム輸送体が腎臓で尿を産生する細胞の細胞内液胞に高発現することを初めて見出しました。○　本研究はマグネシウム排出の新たなメカニズムを理解する重要な手がかりとなります。

  • Mediating Magnesium

    2013/06/21

    Languages： English

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    The gene mechanism responsible for altering magnesium ion secretion in fish is uncovered by scientists at Tokyo Tech

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Degree

  • Doctor of Science ( Tokyo Institute of Technology )

Research Interests

  • Molecular and Cellular Biology, Comparative and Evolutionary Physiology, Fish Physiology

  • 腎臓

  • 代謝

  • ホメオスタシス

  • 細胞生物学

  • 電気生理学

  • トランスポーター

  • 上皮細胞

  • 比較ゲノム

  • Structured Biochemistry

  • Molecular Biology

  • Functional Biochemistry

  • Cell Biology

Research Areas

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Genome biology

  • Life Science / Functional biochemistry

  • Life Science / Morphology and anatomical structure

  • Life Science / Molecular biology

Research History

  • Institute of Science Tokyo   School of Life Science and Technology   Associate Professor

    2024

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    Country：Japan

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  • Tokyo Institute of Technology   School of Life Science and Technology   Associate Professor

    2020 - 2024

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    Country：Japan

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Professional Memberships

Papers

  • Loss and Gain of Aqp10 Paralogs With Broad Solute Selectivity in Anguillid Eels Reviewed

    Ayumi Nagashima, Shinichiro Hidaka, Chihiro Ota, Daisuke Yamanaka, Koichi Ito, Tsutomu Nakada, Tadaomi Furuta, Akira Kato

    Genome Biology and Evolution   2025.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/gbe/evaf169

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  • Aquaporin 10 paralogs exhibit evolutionarily altered urea and boric acid permeabilities based on the amino acid residues at positions 1 and 3 in the ar/R region Reviewed

    Ayumi Nagashima, Kazutaka Ushio, Hidenori Nishihara, Jin Akimoto, Akira Kato, Tadaomi Furuta

    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology   2025.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpregu.00212.2024

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  • Intron turnover of slc26a1 and slc26a2 and convergence of intron insertion sites Reviewed

    Kota Torii, Chihiro Ota, Ayumi Nagashima, Masaki Kajikawa, Akira Kato

    Scientific Reports   2025.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-025-15147-w

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  • Retention and pseudogenization of aquaporin-10 in Rodentia Reviewed

    Ayumi Nagashima, Nodoka Nagai, Chihiro Ota, Kazutaka Ushio, Akira Kato

    Biochemical and Biophysical Research Communications   2025.4

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2025.151608

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  • Electroneutral Na+/Cl- cotransport activity of zebrafish Slc12a10.1 expressed in Xenopus oocytes. Reviewed International journal

    Chihiro Ota, Ayumi Nagashima, Akira Kato

    American journal of physiology. Regulatory, integrative and comparative physiology   2024.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Na+/Cl- cotransporter 2 (Ncc2 or Slc12a10), is a membrane transport protein that belongs to the electroneutral cation-chloride cotransporter family. The Slc12a10 gene (slc12a10) is widely present in bony vertebrates but is deleted or pseudogenized in birds, some bony fishes, and most mammals. Slc12a10 is highly homologous to Ncc (Slc12a3 or Ncc1); however, there are only a few reports measuring the activity of Slc12a10. In this study, we focused on zebrafish Slc12a10.1 (zSlc12a10.1) and analyzed its activity using Xenopus oocyte electrophysiology. Analysis using Na+-selective microelectrodes showed that intracellular sodium activity (aNai) in zSlc12a10.1 oocytes was significantly decreased in Na+- or Cl--free medium and recovered when Na+ or Cl- was readded to the medium. Similar analysis using a Cl--selective microelectrode showed that intracellular chloride activity (aCli) in zSlc12a10.1 oocytes significantly decreased in Na+- or Cl--free medium and recovered when Na+ or Cl- was readded to the medium. When a similar experiment was performed with a voltage clamp, the membrane current did not change when aNai of zSlc12a10.1 oocytes were decreased in Na+-free medium. Molecular phylogenetic and synteny analyses suggest that gene duplication between slc12a10.2 and slc12a10.3 in zebrafish, is a relatively recent event, whereas gene duplication between slc12a10.1 and the ancestral gene of slc12a10.2/slc12a10.3 occurred at least about 2 million years ago. slc12a10 deficiency was observed in species belonging to Ictaluridae, Salmoniformes, Osmeriformes, Batrachoididae, Syngnathiformes, Gobiesociformes, Labriformes, and Tetraodontiformes. These results indicate that zebrafish Slc12a10.1 is an electroneutral Na+/Cl-cotransporter and establish its evolutionary position among various teleost slc12a10 paralogs.

    DOI： 10.1152/ajpregu.00096.2024

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  • slc26a12—A novel member of the slc26 family, is located in tandem with slc26a2 in coelacanths, amphibians, reptiles, and birds Reviewed

    Ayumi Nagashima, Kota Torii, Chihiro Ota, Akira Kato

    Physiological Reports   2024.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.14814/phy2.16089

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  • Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes Reviewed

    Akira Kato, Supriya Pipil, Chihiro Ota, Makoto Kusakabe, Taro Watanabe, Ayumi Nagashima, An-Ping Chen, Zinia Islam, Naoko Hayashi, Marty Kwok-Shing Wong, Masayuki Komada, Michael F. Romero, Yoshio Takei

    Communications Biology   2024.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s42003-024-06103-x

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  • The role of Na+-coupled bicarbonate transporters (NCBT) in health and disease Reviewed

    Shannon R. Holmberg, Yohei Sakamoto, Akira Kato, Michael F. Romero

    Pflügers Archiv - European Journal of Physiology   2024.4

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00424-024-02937-w

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  • Selectivity and evolution of Aqp10 in solute permeability influenced by pore molecular weight

    Ayumi Nagashima, Kazutaka Ushio, Hidenori Nishihara, Jin Akimoto, Akira Kato, Tadaomi Furuta

    2024.3

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    Authorship：Corresponding author  

    DOI： 10.1101/2024.03.16.584933

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  • Functional Divergence in Solute Permeability between Ray-Finned Fish-Specific Paralogs of aqp10 Reviewed

    Genki Imaizumi, Kazutaka Ushio, Hidenori Nishihara, Ingo Braasch, Erika Watanabe, Shiori Kumagai, Tadaomi Furuta, Koji Matsuzaki, Michael F Romero, Akira Kato, Ayumi Nagashima

    Genome Biology and Evolution   2024.1

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/gbe/evad221

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Books

  • Encyclopedia of Fish Physiology (Second Edition)

    Akira Kato, Steve F. Perry（ Role： ContributorThe kidney for osmoregulation）

    Academic Press  2024.4  （ ISBN:9780323997614 ）

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    Responsible for pages：827-838  

    DOI： 10.1016/b978-0-323-90801-6.00180-4

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Presentations

  • slc26a12—A novel member of the slc26 family, is located in tandem with slc26a2 in coelacanths, amphibians, reptiles, and birds

    永嶌 鮎美, 鳥井 宏太, 太田地洋, 加藤 明

    第26回日本進化学会神奈川大会  2024.8 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Poster presentation  

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  • 無胃魚と単孔類における収斂的な遺伝子欠失と偽遺伝子化

    太田 地洋, 永嶌 鮎美, 渡邊 太朗, Michael F. Romero, 竹井 祥郎, 加藤 明

    第26回日本進化学会神奈川大会  2024.8 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Poster presentation  

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  • 条鰭類アクアポリン10パラログの輸送基質選択における機能分岐

    永嶌 鮎美, 潮 和敬, 今泉 元岐, 西原 秀典, 古田 忠臣, Ingo Braasch, 松崎 浩二, Michael F. Romero, 加藤 明

    日本農芸化学会2024年度大会（創立100周年記念大会）  2024.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 条鰭類slc26a1, a2における収斂的なイントロンの獲得

    鳥井 宏太, 加藤 明

    日本動物学会関東支部第76回大会  2024.3 

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    Language：Japanese   Presentation type：Poster presentation  

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  • 魚類ゲノム配列中の膜輸送体遺伝子情報から学ぶ腎臓と消化管の分子メカニズム Invited

    加藤 明

    国立遺伝学研究所研究会 海と生命情報から学ぶ脊椎動物の多様性とその分子基盤  2024.12 

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    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • slc26a1およびslc26a2の系統特異的イントロンターンオーバーとトランスポゾン挿入の関与

    加藤 明, 鳥井 宏太, 永嶌 鮎美, 梶川 正樹

    第47回日本分子生物学会年会  2024.11 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Electroneutral Na+/Cl− cotransport activity of zebrafish Slc12a10.1

    太田 地洋, 永嶌 鮎美, 加藤 明

    第97回日本生化学会大会  2024.11 

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    Language：Japanese   Presentation type：Poster presentation  

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  • トラフグ腎尿細管および腸上皮細胞の頂端膜におけるKcnj15とNkcc2の局在

    坂本 洋平, 鈴木 穣, 加藤 明

    令和７年度 日本水産学会 春季大会  2025.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 造礁サンゴにおけるアクアポリンの輸送基質選択性と機能分化

    永嶌 鮎美, 加藤 明

    日本農芸化学会2025年度大会  2025.3 

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    Language：Japanese   Presentation type：Poster presentation  

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  • 真骨魚類におけるslc12a10パラログの進化

    太田 地洋, 加藤 明

    第47回日本分子生物学会年会  2024.12 

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    Language：Japanese   Presentation type：Poster presentation  

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  • 比較生理学的解析によるAqp10基質選択メカニズムの解明

    永嶌 鮎美, 潮 和敬, 西原 秀典, 秋元 仁, 加藤 明, 古田 忠臣

    第47回日本分子生物学会年会  2024.12 

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Research Projects

  • Molecular characterization of collecting ducts and their mechanisms of water and electrolyte metabolism during acclimation of fishes to fresh water and seawater

    Grant number：23K21234  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\17160000 （ Direct Cost: \13200000 、 Indirect Cost：\3960000 ）

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  • Molecular characterization of collecting ducts and their mechanisms of water and electrolyte metabolism during acclimation of fishes to fresh water and seawater

    Grant number：21H02281  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\17160000 （ Direct Cost: \13200000 、 Indirect Cost：\3960000 ）

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Media Coverage

  • Advances in Understanding the Evolution of Stomach Loss in Agastric Fishes Internet

    Tokyo Institute of Technology  Tokyo Tech News  2025.5

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    Author：Myself 

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  • Butterflies in your stomach? Not an issue for nearly 8000 species of fishes Newspaper, magazine

    Elsevier  Trends in Genetics  Spotlight  2024.5

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    Author：Other 

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