Cationic copolymer and crowding agent have a cooperative effect on a Na+-dependent DNAzyme

Jun Wang, He Huang, Orakan Hanpanich, Naohiko Shimada, Atsushi Maruyama

Biomaterials Science   2023

Encapsulation in cooling-induced coacervates augments DNA enzyme activity

Takuya Komachi, Shunya Kawai, Yuki Hirayama, Atsushi Maruyama, Naohiko Shimada

Polymer Chemistry   2023

Autonomous Vesicle/Sheet Transformation of Cell-Sized Lipid Bilayers by Hetero-Grafted Copolymers

Tsukuru Masuda, Shutaro Takahashi, Takuro Ochiai, Takayoshi Yamada, Naohiko Shimada, Atsushi Maruyama

ACS Applied Materials & Interfaces   2022.11

Smart Protein Refolding System Based on UCST-Type Ureido Polymers

Yamato Tanaka, Chun Hao Niu, Taira Sasaki, Shouhei Nomura, Atsushi Maruyama, Naohiko Shimada

Biomacromolecules   2022.9

Cationic Copolymer-Augmented DNA Hybridization Chain Reaction

Jun Wang, Naohiko Shimada, Atsushi Maruyama

ACS Applied Materials & Interfaces   2022.8

Selective Photo-Crosslinking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer. International journal

Atsuhiro Kojima, Juki Nakao, Naohiko Shimada, Naoki Yoshida, Yota Abe, Yu Mikame, Tsuyoshi Yamamoto, Takehiko Wada, Atsushi Maruyama, Asako Yamayoshi

ACS biomaterials science & engineering   2022.3

A cationic copolymer as a cocatalyst for a peroxidase-mimicking heme-DNAzyme

Haruka Araki, Shota Hagiwara, Ryosuke Shinomiya, Atsuya Momotake, Hiroaki Kotani, Takahiko Kojima, Takuro Ochiai, Naohiko Shimada, Atsushi Maruyama, Yasuhiko Yamamoto

BIOMATERIALS SCIENCE   2021.7

Spatially regulated activation of membrane fusogenic peptides with chaperone-like ionic copolymers

Tomoka Takenaka, Wakako Sakamoto, Shutaro Takahashi, Naohiko Shimada, Atsushi Maruyama

Journal of Controlled Release   330   463 - 469   2021.2

Light-Regulated Liquid–Liquid Phase Separation for Spatiotemporal Protein Recruitment and Cell Aggregation

Nao Ikeuchi, Takuya Komachi, Keiji Murayama, Hiroyuki Asanuma, Atsushi Maruyama, Naohiko Shimada

ACS Applied Materials & Interfaces   13 ( 4 )   5652 - 5659   2021.2

Evaluation of Cooling-Induced Liquid–Liquid Phase Separation of Ureido Polymers as a Cold-Shock Stress Granules Model

Komachi, T., Maruyama, A., Shimada, N

Macromol. Biosci.   2021.1

Crystallization-induced mechanofluorescence for visualization of polymer crystallization

Sota Kato, Shigeki Furukawa, Daisuke Aoki, Raita Goseki, Kazusato Oikawa, Kousuke Tsuchiya, Naohiko Shimada, Atsushi Maruyama, Keiji Numata, Hideyuki Otsuka

Nature Communications   12 ( 126 )   2021.1

One-step isothermal RNA detection with LNA-modified MNAzymes chaperoned by cationic copolymer

Orakan Hanpanich, Ken Saito, Naohiko Shimada, Atsushi Maruyama

Biosensors and Bioelectronics   165   2020.10

Cationic copolymer enhances 8–17 DNAzyme and MNAzyme activities

Krittika Rudeejaroonrung, Orakan Hanpanich, Ken Saito, Naohiko Shimada, Atsushi Maruyama

Biomaterials Science   Volume 8 ( Number 14 )   2020.7

Bundling Process of Citrulline Polypeptides upon UCST-Type Phase Separation

Shota Fujii, Sotaro Kuroyanagi, Naohiko Shimada, Jun Matsuno, Ji Ha Lee, Rintaro Takahashi, Atsushi Maruyama, Kazuo Sakurai

J. Phys. Chem. B   Vol. 124 ( 20 )   4036 - 4043   2020.4

Cationic copolymer-chaperoned DNAzyme sensor for microRNA detection

Orakan Hanpanich, Tomoya Oyanagi, Naohiko Shimada, Atsushi Maruyama

Biomaterials   Vol. 225   2019.12

Cationic Copolymers Act As Chaperones of a Membrane-Active Peptide: Influence on Membrane Selectivity

Wakako Sakamoto, Tsukuru Masuda, Takuro Ochiai, Naohiko Shimada, Atsushi Maruyama

ACS Biomaterials Science & Engineering   2019.11

Cationic copolymer‐chaperoned 2D–3D reversible conversion of lipid membranes

Naohiko Shimada, Hirotaka Kinoshita, Takuma Umegae, Satomi Azumai, Nozomi Kume, Takuro Ochiai, Tomoka Takenaka, Wakako Sakamoto, Takayoshi Yamada, Tadaomi Furuta, Tsukuru Masuda, Minoru Sakurai, Hideo Higuchi, Atsushi Maruyama

Adv. Mater.   vol. 31 ( no. 44 )   1904032 - 1904032   2019.11

Cationic copolymer-chaperoned short-armed 10–23 DNAzymes

Orakan Hanpanich, Hitonari Miyaguchi, Naohiko Shimada, Atsushi Maruyama

Nucleosides, Nucleotides and Nucleic Acids   2019.10

Synthesis and Properties of Upper Critical Solution Temperature Responsive Nanogels International journal

Maho Ohshio, Kazuhiko Ishihara, Atsushi Maruyama, Naohiko Shimada, Shin-ichi Yusa

Langmuir   35 ( 22 )   7261 - 7267   2019.6

Liposome-Surface-Initiated ARGET ATRP: Surface Softness Generated by “Grafting from” Polymerization

Tsukuru Masuda, Naohiko Shimada, Atsushi Maruyama

Langmuir   35 ( 16 )   5581 - 5586   2019.4

Highly ordered polypeptide with UCST phase separation behavior

Sotaro Kuroyanagi, Naohiko Shimada, Shota Fujii, Tadaomi Furuta, Atsushi Harada, Kazuo Sakurai, Atsushi Maruyama

J. Am. Chem. Soc.   vol. 141 ( no. 3 )   1261 - 1268   2019.1

Photo-regulatable DNA isothermal amplification by template-mediated ligation

Bohao Cheng, Hiromu Kashida, Naohiko Shimada, Atsushi Maruyama, Hiroyuki Asanuma

Chem. Commun.   Vol. 55   2018.12

Rational Design of UCST-type Ureido Copolymers Based on a Hydrophobic Parameter Reviewed

Naohiko Shimada, Taira Sasaki, Takakuni Kawano, Atsushi Maruyama

Biomacromolecules   2018.10

(Invited) A Thermo-Responsive Cationic Comb-Type Copolymer Enhances Membrane Permeabilizing Activity of an Amphiphilic Peptide

Tsukuru Masuda, Naohiko Shimada, Atsushi Maruyama

ECS Meeting Abstracts   2018.7

Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers Reviewed

Hiroki Sato, Naohiko Shimada, Tsukuru Masuda, Atsushi Maruyama

Biomacromolecules   19 ( 6 )   2082 - 2088   2018.6

Fluorescence Redox Blinking Adaptable to Structural Analysis of Nucleic Acids Reviewed

Takafumi Miyata, Naohiko Shimada, Atsushi Maruyama, Kiyohiko Kawai

Chemistry - A European Journal   24 ( 26 )   6755 - 6761   2018.5

DNA Computing Boosted by a Cationic Copolymer Reviewed

Naohiko Shimada, Ken Saito, Takafumi Miyata, Hiroki Sato, Satoshi Kobayashi, Atsushi Maruyama

Advanced Functional Materials   28 ( 17 )   2018.4

A Thermoresponsive Cationic Comb-Type Copolymer Enhances Membrane Disruption Activity of an Amphiphilic Peptide Reviewed

Tsukuru Masuda, Naohiko Shimada, Atsushi Maruyama

Biomacromolecules   19 ( 4 )   1333 - 1339   2018.4

Single-Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking

Kiyohiko Kawai, Takafumi Miyata, Naohiko Shimada, Syoji Ito, Hiroshi Miyasaka, Atsushi Maruyama

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   56 ( 48 )   15329 - 15333   2017.11

Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement Reviewed

Bohao Cheng, Hiromu Kashida, Naohiko Shimada, Atsushi Maruyama, Hiroyuki Asanuma

CHEMBIOCHEM   18 ( 16 )   1568 - 1572   2017.8

Design of a Tunable Self-Oscillating Polymer with Ureido and Ru(bpy)3 Moieties Reviewed

Tsukuru Masuda, Naohiko Shimada, Taira Sasaki, Atsushi Maruyama, Aya Mizutani Akimoto, Ryo Yoshida

Angewandte Chemie   129 ( 32 )   9587   2017.8

Cationic comb-type copolymer promotes DNA assembly on gold nanoparticles while enhancing particle dispersibility Reviewed

Hiroki Sato, Naohiko Shimada, Atsushi Maruyama

MACROMOLECULAR RESEARCH   25 ( 6 )   500 - 503   2017.6

Selective and Robust Stabilization of Triplex DNA Structures Using Cationic Comb-type Copolymers

Asako Yamayoshi, Daisuke Miyoshi, Yu-ki Zouzumi, Yohei Matsuyama, Jumpei Ariyoshi, Naohiko Shimada, Akira Murakami, Takehiko Wada, Atsushi Maruyama

JOURNAL OF PHYSICAL CHEMISTRY B   121 ( 16 )   4015 - 4022   2017.4

Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide Reviewed

Wakako Sakamoto, Takuro Ochiai, Naohiko Shimada, Atsushi Maruyama

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   28 ( 10-12 )   1097 - 1108   2017

Preparation and Biomaterial Application of UCST-Type Ureido Polymer Reviewed

Sotaro Kuroyanagi, Atsushi Maruyama, Naohiko Shimada

KOBUNSHI RONBUNSHU   74 ( 4 )   250 - 256   2017

Reversible monolayer/spheroid cell culture switching by UCST-type thermoresponsive ureido polymers Reviewed

Naohiko Shimada, Minako Saito, Sayaka Shukuri, Sotaro Kuroyanagi, Thasaneeya Kuboki, Satoru Kidoaki, Takeharu Nagai, Atsushi Maruyama

ACS Applied Materials and Interfaces   8 ( 46 )   31524 - 31529   2016.11

Preparation of Ureido Group Bearing Polymers and Their Upper Critical Solution Temperature in Water Reviewed

Ami Fujihara, Kohei Itsuki, Naohiko Shimada, Atsushi Maruyama, Naoya Sagawa, Toshiyuki Shikata, Shin-Ichi Yusa

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY   54 ( 18 )   2845 - 2854   2016.9

A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers Reviewed

Nonoka Yamaguchi, Yu-ki Zouzumi, Naohiko Shimada, Shu-ichi Nakano, Naoki Sugimoto, Atsushi Maruyama, Daisuke Miyoshi

CHEMICAL COMMUNICATIONS   52 ( 47 )   7446 - 7449   2016

Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer Reviewed

Ken Saito, Naohiko Shimada, Atushi Maruyama

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   17 ( 1 )   437 - 442   2016

Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide Reviewed International journal

Liu, Q., Somiya, M., Shimada, N., Sakamoto, W., Yoshimoto, N., Iijima, M., Tatematsu, K., Nakai, T., Okajima, T., Maruyama, A., Kuroda, S.

Biochemical and Biophysical Research Communications   474 ( 2 )   406 - 412   2016

Ureido polymers showing UCST-type phase separation behavior Reviewed

Shimada N, Maruyama A

Kobunshi   65 ( 8 )   429 - 430   2016

Inter-polyelectrolyte nano-assembly induces folding and activation of functional peptides Reviewed

Naohiko Shimada, Hirotaka Kinoshita, Shuichi Tokunaga, Takuma Umegae, Nozomi Kume, Wakako Sakamoto, Atsushi Maruyama

JOURNAL OF CONTROLLED RELEASE   218   45 - 52   2015.11

Preparation of upper critical solution temperature (UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water Reviewed

Ami Fujihara, Naohiko Shimada, Atsushi Maruyama, Kazuhiko Ishihara, Keita Nakai, Shin-ichi Yusa

SOFT MATTER   11 ( 26 )   5204 - 5213   2015

MNAzyme-catalyzed nucleic acid detection enhanced by a cationic copolymer Reviewed

Jueyuan Gao, Naohiko Shimada, Atsushi Maruyama

BIOMATERIALS SCIENCE   3 ( 5 )   716 - 720   2015

Science Enhancement of deoxyribozyme activity by cationic copolymers Reviewed

Jueyuan Gao, Naohiko Shimada, Atsushi Maruyama

BIOMATERIALS SCIENCE   3 ( 2 )   308 - 316   2015

Drastic Stabilization of Parallel DNA Hybridizations by a Polylysine Comb-Type Copolymer with Hydrophilic Graft Chain Reviewed

Daisuke Miyoshi, Yu-mi Ueda, Naohiko Shimada, Shu-ichi Nakano, Naoki Sugimoto, Atsushi Maruyama

CHEMMEDCHEM   9 ( 9 )   2156 - 2163   2014.9

A lock-and-key mechanism for the controllable fabrication of DNA origami structures

Arivazhagan Rajendran, Masayuki Endo, Kumi Hidaka, Naohiko Shimada, Atsushi Maruyama, Hiroshi Sugiyama

Chemical Communications   50 ( 63 )   8743 - 8746   2014.7

Thermo-responsive liquid marbles Reviewed

Shin-ichi Yusa, Masashi Morihara, Keita Nakai, Syuji Fujii, Yoshinobu Nakamura, Atsushi Maruyama, Naohiko Shimada

POLYMER JOURNAL   46 ( 3 )   145 - 148   2014.3

DNA strand exchange reaction activated by cationic comb-type copolymers having ureido groups Reviewed

Naohiko Shimada, Wei Song, Atsushi Maruyama

BIOMATERIALS SCIENCE   2 ( 10 )   1480 - 1485   2014

Smart hydrogels exhibiting UCST-type volume changes under physiologically relevant conditions Reviewed

Naohiko Shimada, Satoru Kidoaki, Atsushi Maruyama

RSC ADVANCES   4 ( 94 )   52346 - 52348   2014

Cationic Comb-Type Copolymer Excludes Intercalating Dye from DNA Without Inducing DNA Condensation Reviewed

Atsushi Maruyama, Naotaka Sonda, Kohei Yamasaki, Masanori Hirano, Satoru Kidoaki, Naohiko Shimada, Masatoshi Maeshiro, Masaya Miyazaki

CURRENT NANOSCIENCE   10 ( 2 )   185 - 188   2014

Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe Reviewed

Hisao Saneyoshi, Naohiko Shimada, Atsushi Maruyama, Yoshihiro Ito, Hiroshi Abe

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   23 ( 24 )   6851 - 6853   2013.12

Tumor delivery of Photofrin (R) by PLL-g-PEG for photodynamic therapy Reviewed

Arihiro Kano, Yuki Taniwaki, Izumi Nakamura, Naohiko Shimada, Kenji Moriyama, Atsushi Maruyama

JOURNAL OF CONTROLLED RELEASE   167 ( 3 )   315 - 321   2013.5

Design of UCST Polymers for Chilling Capture of Proteins Reviewed

Naohiko Shimada, Miki Nakayama, Arihiro Kano, Atsushi Maruyama

BIOMACROMOLECULES   14 ( 5 )   1452 - 1457   2013.5

Thermoresponsive polymers with functional groups selected for pharmaceutical and biomedical applications Reviewed

Naohiko Shimada, Atsushi Maruyama

ACS Symposium Series   1135   235 - 241   2013

Polyelectrolyte-assisted transconformation of a stem-loop DNA Reviewed

Jie Du, Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

CHEMICAL COMMUNICATIONS   49 ( 5 )   475 - 477   2013

alpha-amino acid pendant polymers as endosomal pH-responsive gene carriers Reviewed

Takuya Wada, Arihiro Kano, Naohiko Shimada, Atsushi Maruyama

MACROMOLECULAR RESEARCH   20 ( 3 )   302 - 308   2012.3

A polycation-chaperoned in-stem molecular beacon system

Hiroyuki Asanuma, Takuya Osawa, Hiromu Kashida, Taiga Fujii, Xingguo Liang, Kosuke Niwa, Yasuko Yoshida, Naohiko Shimada, Atsushi Maruyama

Chemical Communications   48 ( 12 )   1760 - 1762   2012.1

Preparation of Cationic Comb-Type Copolymer Having Tetra-Alkylammonium Groups and its Interaction with DNA Reviewed

Rui Moriyama, Junji Mochida, Asako Yamayoshi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

CURRENT NANOSCIENCE   7 ( 6 )   979 - 983   2011.12

The role of cationic comb-type copolymers in chaperoning DNA annealing Reviewed

Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

BIOMATERIALS   32 ( 30 )   7671 - 7676   2011.10

Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(L-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions Reviewed

Naohiko Shimada, Haruka Ino, Kenji Maie, Miki Nakayama, Arihiro Kano, Atsushi Maruyama

BIOMACROMOLECULES   12 ( 10 )   3418 - 3422   2011.10

DNA assembly and re-assembly activated by cationic comb-type copolymer Reviewed

Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

BIOMATERIALS   32 ( 9 )   2351 - 2358   2011.3

Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules Reviewed

Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

CHEMISTRY LETTERS   40 ( 3 )   250 - 251   2011.3

Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA

Kano Arihiro, Moriyama Kenji, Yamano Takeshi, Nakamura Izumi, Shimada Naohiko, Maruyama Atsushi

Journal of Controlled Release   149 ( 1 )   2 - 7   2011.1

Cationic Graft Copolymer as a DNA B-Z Transition Inducer: Effect of Copolymer Structure Reviewed

Naohiko Shimada, Miyuki Yamamoto, Arihiro Kano, Atsushi Maruyama

BIOMACROMOLECULES   11 ( 11 )   3043 - 3048   2010.11

B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer Reviewed

Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

ADVANCED FUNCTIONAL MATERIALS   19 ( 22 )   3590 - 3595   2009.11

Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone

Nobuyuki Morimoto, Junko Tamada, Shin-ichi Sawada, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama, Kazunari Akiyoshi

CHEMISTRY LETTERS   38 ( 5 )   496 - 497   2009.5

Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex. Reviewed

Moriyama R, Shimada N, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 53 )   61 - 62   2009

Design of cationic graft copolymers as a potential inducer of B-Z transition. Reviewed

Shimada N, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 53 )   251 - 252   2009

Relationships of Conformation and Function of Homo-Poly-Nucleotide Conjugated Thrombin Aptamers Reviewed

Shuichiro Uehara, Naohiko Shimada, Mina Sakuragi, Kazuo Sakurai

KOBUNSHI RONBUNSHU   66 ( 11 )   519 - 523   2009

Uptake of Enzymatically-Digested Hyaluronan by Liver Endothelial Cells in Vivo and in Vitro Reviewed

Shinichi Mochizuki, Arihiro Kano, Naohiko Shimada, Atsushi Maruyama

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   20 ( 1 )   83 - 97   2009

3 ' Poly(dA)-Tailed Thrombin DNA Aptamer to Increase DNase-Resistance and Clotting Inhibitory Activity Reviewed

Shuichiro Uehara, Naohiko Shimada, Yoichi Takeda, Yoshikazu Koyama, Yoshifumi Takei, Hironori Ando, Susumu Satoh, Atsushi Uno, Kazuo Sakurai

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   81 ( 11 )   1485 - 1491   2008.11

Amidine-bearing lipoplex targeting to hepatocyte cells Reviewed

Yasuya Kudo, Kazunori Koiwai, Kazuhiro Shimizu, Shota Kusuki, Mina Sakuragi, Naohiko Shimada, Yoichi Takeda, Kazuo Sakurai

CHINESE CHEMICAL LETTERS   19 ( 9 )   1115 - 1118   2008.9

Entrapment of immature amyloid protofilaments in the hydrophobic domain of schizophyllan Reviewed

Mina Sakuragi, Yoichi Takeda, Naohiko Shimada, Kazuo Sakurai

POLYMER BULLETIN   61 ( 1 )   107 - 117   2008.7

PMSE 311-Cluster effect of CpG sequences in TLR-9 recognition Reviewed

Jusaku Minari, Naohiko Shimada, Kazuo Sakurai

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   235   2008.4

Clustered CpG sequences to enhance cytokine secretion from macrophages Reviewed

Jusaku Minari, Naohiko Shimada, Kazuo Sakurai

CHEMISTRY LETTERS   37 ( 1 )   92 - 93   2008.1

Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life

Takeshi Yamano, Sung Won Choi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

8th World Biomaterials Congress 2008   3   1537   2008

Effect of cationic comb-type copolymer on the B-Z transition of poly(dG-dC).poly(dG-dC). Reviewed

Shimada N, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 52 )   113 - 114   2008

Analysis of cationic comb-type copolymers/DNA interaction by the single molecular observation and intermolecular force measurement. Reviewed

Hirano M, Shimada N, Kano A, Kidoaki S, Maruyama A

Nucleic acids symposium series (2004)   ( 52 )   715 - 716   2008

Poly (L-lysine)-graft-dextran acts as a nucleic acid chaperone for tetramolecular quadruplex formation. Reviewed

Moriyama R, Shimada N, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 52 )   227 - 228   2008

Novel genotyping method using cationic comb-type copolymers Reviewed

Shimada N, Muraki K, Kano A, Maruyama A

8th World Biomaterials Congress 2008   4   2008

Application of partially double-stranded DNA probes to high-throughput SNPs genotyping. Reviewed

Ishii T, Muraki K, Shimada N, Kano A, Nishida N, Tokunaga K, Maruyama A

Nucleic acids symposium series (2004)   ( 52 )   237 - 238   2008

Kinetic effect of cationic comb-type copolymers on DNA hybridization Reviewed

Atsushi Maruyama, Longliang Wu, Naohiko Shimada, Arihiro Kano

MULTI-FUNCTIONAL MATERIALS AND STRUCTURES, PTS 1 AND 2   47-50   1355 - 1358   2008

Poly(L-lysine)-graft-dextran copolymer accelerates DNA hybridization by two orders Reviewed

Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

SOFT MATTER   4 ( 4 )   744 - 747   2008

Abundant graft chains do not influence coil-to-helix but alpha-to-beta transition of polylysine backbone, resulting in thermoreversible beta-to-alpha transition Reviewed

Rui Moriyama, Sung Won Choi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

REACTIVE & FUNCTIONAL POLYMERS   67 ( 11 )   1381 - 1387   2007.11

A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells Reviewed

Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J. Ishii, Kazuo Sakurai

BIOCONJUGATE CHEMISTRY   18 ( 4 )   1280 - 1286   2007.7

DNA binding of tilorone: H-1 NMR and calorimetric studies of the intercalation Reviewed

Tomoki Nishimura, Tadashi Okobira, Andrew M. Kelly, Naohiko Shimada, Yoichi Takeda, Kazuo Sakurai

BIOCHEMISTRY   46 ( 27 )   8156 - 8163   2007.7

Delivery of antisense oligonucleotides to nuclear telomere RNA by use of a complex between polysaccharide and polynucleotide Reviewed

Jusaku Minari, Takanori Kubo, Hideki Ohba, Naohiko Shimada, Yoich Takeda, Ryouji Karinaga, Takahisa Anada, Kazuya Koumoto, Takeshi Kawazu, Takeshi Nagasaki, Seiji Shinkai, Kazuo Sakurai

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   80 ( 6 )   1091 - 1098   2007.6

Ternary complex consisting of DNA, polycation, and a natural polysaccharide of schizophyllan to induce cellular uptake by antigen presenting cells

Yoichi Takeda, Naohiko Shimada, Kenji Kaneko, Seiji Shinkai, Kazuo Sakurai

Biomacromolecules   8 ( 4 )   1178 - 1186   2007.4

DNA conformational switching by use of an intercalator and its receptor Reviewed

Tomoki Nishimura, Yoichi Takeda, Naohiko Shimada, Kazuo Sakurai

CHEMISTRY LETTERS   36 ( 3 )   388 - 389   2007.3

Complex made from tetrasodium N,N-bis(carboxylatomethyl) glutamate and sodium oleate that forms a highly ordered lamella in gel phase Reviewed

Yeonhwan Jeong, Kazuya Uezu, Masataka Kobayashi, Shinichi Sakurai, Hiroyasu Masunaga, Katuaki Inoue, Sono Sasaki, Naohiko Shimada, Yoichi Takeda, Kenji Kaneko, Kazuo Sakurai

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   80 ( 2 )   410 - 417   2007.2

Novel analysis for single nucleotide polymorphism using cationic comb-type copolymers. Reviewed

Shimada N, Muraki K, Anai T, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 51 )   339 - 340   2007

Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization. Reviewed

Wu L, Shimada N, Kano A, Maruyama A

Nucleic acids symposium series (2004)   ( 51 )   73 - 74   2007

Polyrotaxane/DNA conjugate by use of intercalation: Bridge formation between DNA double helices Reviewed

Kenji Tokuhisa, Emi Hamada, Ryouji Karinaga, Naohiko Shimada, Yoichi Takeda, Shinichi Kawasaki, Kazuo Sakurai

MACROMOLECULES   39 ( 26 )   9480 - 9485   2006.12

Encapsulation of ferricytochrome c into the nanoparticle made from a natural polysaccharide: Schizophyllan Reviewed

Mika Kasuga, Naohiko Shimada, Yoichi Takeda, Seiji Shinkai, Kazuo Sakurai

CHEMISTRY LETTERS   35 ( 10 )   1120 - 1121   2006.10

Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier

Naohiko Shimada, Ken J. Ishii, Yoichi Takeda, Cevayir Coban, Yuichi Torii, Seiji Shinkai, Shizuo Akira, Kazuo Sakurai

BIOCONJUGATE CHEMISTRY   17 ( 5 )   1136 - 1140   2006.9

Investigation of interaction between Tilorone and DNA

Tomoki Nishimura, Kenji Tokuhisa, Naohiko Shimada, Yoichi Takeda, Kazuo Sakurai

Polymer Preprints, Japan   55 ( 2 )   4838   2006

Property of polysaccharide nano gel involves polyion complex consists of cationic polymer/ DNA Reviewed

Yoichi Takeda, Naohiko Shimada, Kenji Kaneko, Kazuo Sakurai, Seiji Shinkai

Polymer Preprints, Japan   55 ( 1 )   1858   2006

Inhibition of the amyloid-fibril growth by forming complex between polysaccharide and lysozyme

Mina Sakuragi, Naohiko Shimada, Kazuo Sakurai, Seiji Shinkai

Polymer Preprints, Japan   55 ( 1 )   2136   2006

Selective incorporation of hydrophobic probe into schzophyllan(SPG)

Naohiko Shimada, Yoichi Takeda, Seiji Shinkai, Kazuo Sakurai

Polymer Preprints, Japan   55 ( 1 )   2095   2006

Structure and targeting capability of galactose-appended TRX

Yasuya Kudo, Shota Kusuki, Kenji Tokuhisa, Naohiko Shimada, Yoichi Takeda, Kazuo Sakurai, Kazunori Koiwai

Polymer Preprints, Japan   55 ( 1 )   2054   2006

Synthesis and characterization of polysaccharide-oligonucleotide conjugate

Naoya Fukuda, Naohiko Shimada, Seiji Shinkai, Kazuo Sakurai

Polymer Preprints, Japan   55 ( 2 )   4828   2006

Selection of RNA-binding peptides containing an Arg-rich motif Reviewed

Naohiko Shimada, Reiko Iwase, Tetsuji Yamaoka, Akira Murakami

Chemistry Letters   33 ( 3 )   212 - 213   2004.3

Transcriptome analysis using fluorescence-labeled oligonucleotide. Reviewed

Naohiko Shimada, Atsushi Mahara, Takashi Sakamoto, Tetsuji Yamaoka, Akira Murakami

Nucleic acids symposium series (2004)   48 ( 48 )   301 - 302   2004

Design of RNA-binding oligopeptides based on information of RNA-binding protein Reviewed

Naohiko Shimada, Reiko Iwase, Tetsuji Yamaoka, Akira Murakami

Polymer Journal   35 ( 6 )   507 - 512   2003

Annealing activity of cationic comb-type copolymers for DNA assembly

Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   243   2012.3

尿素基を有するカチオン性くし型共重合体の核酸シャペロン活性の評価

SONG Wei, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   61 ( 1 )   2012

バイオマテリアルとしての応用を目指したUCST型挙動を示すウレイド高分子の設計

嶋田直彦, 中山美紀, 狩野有宏, 丸山厚

高分子学会医用高分子シンポジウム講演要旨集   41st   2012

α-アミノ酸をビルディングブロックとしたpH感受性遺伝子キャリア

和田拓也, 狩野有宏, 嶋田直彦, 丸山厚

日本DDS学会学術集会プログラム予稿集   28th   2012

肝内皮細胞の分離と免疫機能解析

宿利沙郁可, 嶋田直彦, 狩野有宏, 丸山厚

日本バイオマテリアル学会シンポジウム予稿集   2012   2012

尿素基を有するカチオン性くし型共重合体の核酸シャペロン活性の評価

SONG Wei, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   61 ( 2 )   2012

四重鎖DNAに対するカチオン性グラフト共重合体のアニーリング活性

森山塁, 嶋田直彦, 狩野有宏, 丸山厚

バイオ・高分子シンポジウム講演要旨集   21st   2011

α-アミノ酸修飾ポリカチオンの遺伝子キャリアとしての性質

和田拓也, 狩野有宏, 嶋田直彦, 丸山厚

高分子学会予稿集(CD-ROM)   60 ( 1 Disk1 )   2011

カチオン性くし型共重合体による両親媒性酸性ペプチドの構造・機能制御

徳永修一, 狩野有宏, 嶋田直彦, 丸山厚

高分子学会予稿集(CD-ROM)   60 ( 2 Disk1 )   2011

カチオン性くし型共重合体による膜障害性ペプチドの二次構造と活性制御

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   60 ( 1 Disk1 )   2011

Folding Manipulation for Functional Biopolymer Design

SHIMADA Naohiko, MARUYAMA Atsushi

59 ( 8 )   597 - 600   2010.8

分子間四重鎖DNA 形成に対するカチオン性共重合体の核酸シャペロン活性機能

森山塁, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 1 Disk1 )   2010

αアミノ酸のpH応答性に着目した遺伝子キャリア設計

和田拓也, 狩野有宏, 嶋田直彦, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 2 Disk1 )   2010

生理的条件下で高温溶解相転移を示すポリアリルアミン誘導体

嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会医用高分子シンポジウム講演要旨集   39th   2010

高い塩基変異識別能を有する新規二重鎖核酸プローブの設計

梶山力, 狩野有宏, 嶋田直彦, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 1 Disk1 )   2010

カルバミル基を導入したポリカチオン性くし型共重合体の合成とDNAとの相互作用解析

猪野陽佳, 嶋田直彦, 狩野有宏, 丸山厚

日本バイオマテリアル学会大会予稿集   32nd   2010

生理的条件下において上限臨界溶液温度を示すポリアリルアミン誘導体

嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 1 Disk1 )   2010

フローストレッチング法によるカチオン性共重合体/DNAの相互作用解析

尊田尚孝, 平野昌典, 嶋田直彦, 狩野有宏, 丸山厚

日本バイオマテリアル学会大会予稿集   32nd   2010

PLL-g-PEG共重合体と光線力学療法剤の複合化と腫瘍集積性

谷脇勇輝, 森山健司, 中村いずみ, 嶋田直彦, 狩野有宏, 丸山厚

日本バイオマテリアル学会大会予稿集   32nd   2010

カチオン性くし型共重合体による膜融合ペプチドの構造と機能制御

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 1 Disk1 )   2010

ポリ(L-リシン)-グラフト-ポリエチレングリコール共重合体(PLL-g-PEG)の光線力学療法剤ポルフィマーナトリウムとの相互作用と腫瘍デリバリー

狩野有宏, 中村いずみ, 森山健司, 嶋田直彦, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 2 Disk1 )   2010

UCST挙動を示すポリアリルアミン誘導体

嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 2 Disk1 )   2010

α-アミノ酸のpH感受性に着目した遺伝子キャリア設計

和田拓也, 狩野有宏, 嶋田直彦, 丸山厚

日本バイオマテリアル学会大会予稿集   32nd   2010

フローストレッチング法を利用したポリカチオン-DNA間相互作用解析

尊田尚孝, 平野昌典, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 2 Disk1 )   2010

カチオン性くし型共重合体による膜融合ペプチドのシャペロニング

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   59 ( 2 Disk1 )   2010

DNAのB-Z転移に与えるカチオン性くし型共重合体の効果

嶋田直彦, 狩野有宏, 丸山厚

バイオ・高分子シンポジウム講演要旨集   19th   2009

カチオン性くし型共重合体と酸性ペプチドの相互作用解析

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 1 Disk1 )   2009

カチオン性くし型共重合体による両親媒性酸性ペプチドの構造制御

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

バイオ・高分子シンポジウム講演要旨集   19th   2009

カチオン性くし型共重合体と酸性ペプチドの相互作用解析

徳永修一, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 2 Disk1 )   2009

高い塩基変異識別能を持つ新規二重鎖核酸プローブの設計

梶山力, 狩野有宏, 嶋田直彦, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 1 Disk1 )   2009

部分二重鎖プローブおよびカチオン性共重合体を用いたRNA解析

中村麻子, 嶋田直彦, 石井智也, 村木健太郎, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 2 Disk1 )   2009

DNAのB-Z転移を誘起するカチオン性くし型共重合体の設計

嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 2 Disk1 )   2009

分子間DNA四重鎖に対するカチオン性共重合体のシャペロン活性評価

森山塁, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   58 ( 2 Disk1 )   2009

siRNAとの相互作用に及ぼすポリリシン側鎖にグラフトしたPEG鎖の影響

狩野有宏, 中村いずみ, 山野剛, 嶋田直彦, 丸山厚, 丸山厚

遺伝子・デリバリー研究会シンポジウム要旨集   9th   2009

Polysaccharide-templated twisted assemble of 2-anilinonaphthalene-6-sulfonic acid

Naohiko Shimada, Tadashi Okobira, Yoichi Takeda, Seiji Shinkai, Kazuo Sakurai

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY   46 ( 4 )   1440 - 1448   2008.2

カチオン性共重合体による分子間四重鎖DNAの形成制御

森山塁, 嶋田直彦, 狩野有広, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 2 Disk1 )   2008

カチオン性共重合体が分子間DNA四重鎖構造形成に与える影響

森山塁, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 1 Disk1 )   2008

ヒアルロン酸グラフト共重合体による核酸デリバリー法の開発とその評価

城山宗一郎, 狩野有宏, 望月慎一, 嶋田直彦, 丸山厚, 丸山厚

日本バイオマテリアル学会シンポジウム予稿集   2008   2008

ポリリシン-g-ポリエチレングリコール共重合体(PLL-g-PEG)の細胞取り込みと動態評価

芥川礼, 山野剛, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

日本バイオマテリアル学会シンポジウム予稿集   2008   2008

高分子電解質複合体形成による核酸構造のスイッチング

WU Longlian, 森山塁, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

バイオ・高分子シンポジウム講演要旨集   18th   2008

部分二重鎖プローブとカチオン性くし型共重合体を使ったハイスループットジェノタイピング

嶋田直彦, 村木健太郎, 石井智也, 中村麻子, 狩野有宏, 丸山厚, 西田奈央, 徳永勝士

バイオ・高分子シンポジウム講演要旨集   18th   2008

部分二重鎖DNAプローブとカチオン性くし型共重合体を利用したハイスループットジェノタイピング

嶋田直彦, 石井智也, 狩野有宏, 西田奈央, 徳永勝士, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 2 Disk1 )   2008

ヒアルロン酸グラフト共重合体の細胞選択的核酸デリバリーへの応用

城山宗一郎, 狩野有宏, 望月慎一, 嶋田直彦, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 2 Disk1 )   2008

カチオン性くし型共重合体によるリポソームの表面改質

岩田智喜, 狩野有宏, 嶋田直彦, 丸山厚, 丸山厚

薬剤学   68 ( Supplement )   2008

ボトルブラシ型Polylysin-g-PGの腫瘍集積性とsiRNA安定化能

狩野有宏, 嶋田直彦, 丸山厚, 丸山厚

遺伝子・デリバリー研究会シンポジウム要旨集   8th   2008

ポリリシン-g-ポリエチレングリコール共重合体(PLL-g-PEG)の細胞取り込みと動態評価

芥川礼, 山野剛, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 2 Disk1 )   2008

DNAのB-Z転移に与えるカチオン性くし型共重合体の効果

嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   57 ( 2 Disk1 )   2008

PEGブラシによるsiRNAポリプレックスの強化

山野剛, 山吉麻子, 崔成源, 島田直彦, 狩野有宏, 丸山厚, 丸山厚

遺伝子・デリバリー研究会シンポジウム要旨集   7th   2007

カチオン性くし型共重合体とリポソームとの相互作用評価

岩田智喜, 望月慎一, 狩野有宏, 嶋田直彦, 丸山厚, 丸山厚

日本バイオマテリアル学会大会予稿集   29th   2007

親水性グラフト鎖によるポリリシン主鎖骨格の二次構造転移制御

森山塁, CHOI Song Won, 嶋田直彦, 狩野有広, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   56 ( 2 Disk1 )   2007

PEG密生層によるオリゴ核酸ポリプレックスの安定化

山野剛, 山吉麻子, CHOI Sung Won, 嶋田直彦, 狩野有宏, 丸山厚, 丸山厚

高分子学会予稿集(CD-ROM)   56 ( 2 Disk1 )   2007

Complex formation between cationic beta-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion

Masato Ikeda, Jusaku Minari, Naohiko Shimada, Munenori Numata, Kazuo Sakurai, Seiji Shinkai

ORGANIC & BIOMOLECULAR CHEMISTRY   5 ( 14 )   2219 - 2224   2007

An antigen conjugated SPG carrier for imunostimulatory CpG DNAs

Naohiko Shimada, Kazuo Sakurai, Yoichi Takeda, Seiji Shinkai, Seiji Shinkai, Ken Ishii

Polymer Preprints, Japan   55   1954   2006.10

PMSE 39-Nanostructured polyurethane-POSS hybrid dispersions by the prepolymer mixing process

Jusaku Minari, Takanori Kubo, Naohiko Shimada, Yoichi Takeda, Takeshi Nagasaki, Seiji Shinkai, Kazuo Sakurai

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   232   162 - 162   2006.9

PMSE 229-Carbon nanotubes: Getting more grunt out of conducting polymers!

Shota Kusuki, Kazunori Koiwai, Yasuya Kudo, Yoichi Takeda, Naohiko Shimada, Kazuo Sakurai

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   232   174 - 174   2006.9

Selection of RNA-binding peptides containing Arg-rich motif.

Naohiko Shimada, Keiichiro Oniwa, Reiko Iwase, Tetsuji Yamaoka, Akira Murakami

Nucleic acids research. Supplement (2001)   2 ( 2 )   281 - 282   2002

人工シャペロン高分子強化型膜活性ペプチドが誘導する脂質膜構造転移の解析

島崎陸, 根岸洋一, 山吉麻子, 嶋田直彦, 丸山厚

第47回日本バイオマテリアル学会大会  2025.11 

酵素反応に応答して液液相分離するウレイド高分子の構築

森岡 優佳, 楠瀬 黎, 丸山 厚, 嶋田 直彦

第74回高分子討論会  2025.9 

温度感応性材料及びその用途

丸山 厚, 嶋田 直彦, 遊佐 真一

感温性ポリアミノ酸またはその塩

嶋田 直彦, 丸山 厚

温度、pH及び塩濃度感応性分離材及びその用途

嶋田 直彦, 丸山 厚

イン・ステムビーコン型プローブ用のハイブリダイゼーション剤及びその利用

丸山 厚, 嶋田 直彦, 浅沼 浩之, 梁 興国, 樫田 啓, 藤井 大雅, 大澤 卓矢, 吉田 安子, 丹羽 孝介

アリールメチルアミン誘導体およびその塩ならびにそれを構成成分とする薬物担体

櫻井 和朗, 楠木 翔太, 濱田 衣美, 工藤 泰也, 嶋田 直彦, 武田 陽一, 小岩井 一倫

Th2細胞関連疾患の予防等に用いられる核酸/多糖複合体

新海 征治, 櫻井 和朗, 嶋田 直彦, 審良 静男, 石井 健

瞬速生体分子ロボットのための分子ブースター創製

Grant number：25104520  2013.4 - 2015.3

日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

嶋田 直彦

Evaluation of cellular functions by imaging cellular nucleic acids

Grant number：23107007  2011.4 - 2016.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Maruyama Atsushi, SHIMADA NAOHIKO

Development of DNA B-Z inducer as expression of cancer suppressor gene

Grant number：22750157  2010 - 2011

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

SHIMADA Naohiko

Design of cationic molecule as a potential B-Z transition inducer

Grant number：20750140  2008 - 2009

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

SHIMADA Naohiko