Updated on 2025/07/02

写真a

 
IWAI NORITAKA
 
Organization
School of Life Science and Technology Assistant Professor
Title
Assistant Professor
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Degree

  • Doctor of Engineering ( Tokyo Institute of Technology )

Research Interests

  • Microbiology(other than viruses)

  • 微生物学（ウイルス以外）

Research Areas

  • Life Science / Applied microbiology

Education

  • Tokyo Institute of Technology   School of Bioscience and Biotechnology

    - 1997

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    Country： Japan

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Professional Memberships

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Papers

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MISC

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Research Projects

  • Analysis and application of microbial acquired fluorometabolism

    Grant number：25850067  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Iwai Noritaka, WACHI Masaaki, YAMAZAKI Takashi

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    Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）

    We discovered Rhodococcus sp. 065240, which degrades the benzotrifluoride through defluorination. As a result of molecular biological analysis, it was found that this strain possesses btf gene cluster, which is similar to isopropyl benzene degradation cluster. Those genes were related to benzotrifluoride defluorination that suggested by experiments of btf genes deletion mutant. Confirmation of using heterologous btf gnen expression in Corynebacterium glutamicum found that oxidation reaction of benzotrifluoride which catalyzed by BtfA and BtfB, produced trifluoromethyl catechol. Then, basic condition of culture seems to lead spontaneous defluorination of catechol compound. Therefore, it was suggested that applying btfC gene under acidic condition with btfAB not only suppresses defluorination but also transforms benzotrifluoride to new fluorometabolite.

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  • The construction for recycle of fluorine resource with the complex method

    Grant number：20245032  2008 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    KITAZUME Tomoya, IWAI Noritaka

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    Grant amount：\49530000 （ Direct Cost: \38100000 、 Indirect Cost：\11430000 ）

    We have found the isolation of bacterial strains capable of degrading fluorinated materials, 8 strains of Actinobacteria exhibited degradability of ethyl difluoroacetate(DFAc) was accumulated by bacteria, giving difluoroacetic acid and then fluoride ion. Further, 13 strains of Actinobacteria exhibited degradability of fluorobenzene and/or benzotrifluoride. In batch culture, growth of strains on fluorinated materials led to the release of fluoride ion. We have established the one-pot three-step continuous enzymatic synthesis of 5-fluoro-5-deoxy-D-ribose(5-FDR) from ATP and L-methionine using S-adenosyl-L-methionine synthase(MetK), fluorinase and methylthioadenosinenucleosidase(MtnN) in the presence of fluoride ion. Especially, for the purpose of thesustainable development of fluorine chemistry, we have established the reuse of fluoride ion generated from BF4 ionic liquids and/or the biodegradation of BTF in the one-pot synthetic process to 5-FDR. Further, we have established the retransformation of fluoride ion generated from biodegradation of BTF to calcium fluoride.

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  • Synthesis and synthetic utilities of functionalized reaction system in ionic liquids

    Grant number：17073007  2005 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Priority Areas

    KITAZUME Tomoya, YAMAZAKI Takashi, IWAI Noritaka

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    Grant amount：\78200000 （ Direct Cost: \78200000 ）

    We have established new ionic liquid reaction systems for the organic reactions. 1) We have reported the utilities of ionic liquid-supported NHPI complexes as recoverable and recyclable systemfor the oxidation and nitration. 2) Ionic liquids have recognized as a solvent for Geotrichum candidum-catalyzed optical resolution and/or deracemization of rcemic secondary alcohols, giving optically active alcohols.

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