掲載種別：研究論文（学術雑誌）   出版者・発行元：Institute of Electrical and Electronics Engineers (IEEE)  

DOI： 10.1109/tmech.2023.3290970

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00157/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

<jats:title>Abstract</jats:title><jats:p>High-efficiency plasma skimming is hopeful to prevent hemolysis inside spiral groove bearings (SGBs) because it can exclude red blood cells from the ridge gap with a high shear force. However, no study reveals the shape design of SGBs to improve plasma skimming. Therefore, this study proposed and applied a groove design strategy to designing an optimal SGB for enhancing plasma skimming in a rotary blood pump (RBP). Initially, we proposed the design strategy that the shape of the groove for enhancing plasma skimming corresponds to the direction of blood flow in the ridge gap. Second, we visualized the cell flow in a specially designed experimental RBP to determine the direction of blood flow, which was helpful in the subsequent SGB design. Then, we created an SGB to provide superior plasma skimming and applied it to the experimental RBP. We evaluated the plasma skimming effect of SGB at rotational speeds ranging from 2400 to 3000 rpm and hematocrit conditions between 1% and 40%. At a 1% hematocrit, the plasma skimming efficiency for the entire SGB was greater than 95%. In all hematocrit conditions, the efficiency at the inner ridges of the SGB was greater than 80%. The results showed the designed SGB successfully induced excellent plasma skimming within ridge gaps. This study is the first to propose and apply a shape design strategy to generate excellent plasma skimming within an SGB. This study may contribute to the prevention of SGB hemolysis inside SGB for use in RBPs.</jats:p>

DOI： 10.1007/s10047-023-01422-y

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その他リンク： https://link.springer.com/article/10.1007/s10047-023-01422-y/fulltext.html

担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Institute of Electrical Engineers of Japan  

Wireless power transfer based on magnetic resonant coupling can be used to supply power to a mobile robot within a few meters of a transmitter coil. However, when the robot moves or its power consumption fluctuates, its input impedance varies significantly and, in case of impedance mismatch, power reflection may occur. To address this issue, we employed a driver coil on the transmitter side to match input impedance. By regulating the coupling coefficient between the driver and the transmitter coils, the input impedance is matched and power reflection is eliminated. Input impedance regulation is achieved by moving the driver coil mechanically. As confirmed by our experiments, the transmitting efficiency matched with the analytically calculated value, and the input impedance was matched for a vast range of distances from 0 to 1m and load resistances from 4 to 210 Ω by moving the driver coil properly. Therefore, the proposed system successfully addresses the power reflection problem in wireless power transfer for mobile robots.

DOI： 10.1541/ieejjia.22009525

DOI： 10.1541/ieejjia.24002906_references_DOI_KWVpXK74KxGuuRoDcRdFltO9FCm

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I033032496

記述言語：英語   出版者・発行元：IEEE  

For the practical application of bio-actuators, it is desired to develop a precise control method for skeletal muscles. In this study, a novel model-based control method has been proposed. The control method enables skeletal muscles to exert an arbitrary magnitude of contraction force, rather than just the conventional on/off control. First, we proposed a control system to obtain the optimized electrical stimulation voltage, that can reproduce reference force. In order to actually apply the method, a bio-actuator consisting of a skeletal muscle of a frog was manufactured for a verification experiment. First, muscle contraction model parameters that could reproduce the contractile response of the gastrocnemius muscle were identified from the experimental data. Next, based on this model, the proposed control method was used to calculate the stimulation voltage to exert the reference force. The voltage was applied to the bio-actuator to control the contraction force. As a results, the output of the actuator was able to follow the stepwise reference force. Our proposed control method demonstrates the feasibility of precise control of bio-actuators.Clinical Relevance- If skeletal muscles could be used as actuators for power-assistive suits, it would be possible to develop power-assistive suits that are more compatible with people and reduce the burden on caregivers in the field of nursing care. The method proposed in this study will enable the control of skeletal muscle contraction force by electrical stimulation, bringing skeletal muscle actuators closer to practical application.

DOI： 10.1109/EMBC40787.2023.10341011

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記述言語：日本語   出版者・発行元：国立 : 日本AEM学会  

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I032956708

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Mechanical circulatory support devices, such as left ventricular assist devices, have recently been used in patients with heart failure as destination therapy but the formation of thrombus in blood pumps remains a critical problem. In this study, we propose a mechanical antithrombogenic method by impeller excitation using a magnetically levitated (Maglev) centrifugal pump. Previous studies have shown that one‐directional excitation prevents thrombus; however, it is effective in only one direction. In this study, we aimed to obtain a better effect by vibrating it in a circular orbit to induce uniform changes in the shear‐rate field entirely around the impeller.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The blood coagulation time was compared using porcine blood. (1) The flow rate was set to 1 L/min, and applied excitation was at a frequency of 280 Hz and amplitude of 3 μm. (2) Moreover, the effect was compared by varying the frequency, amplitude, and direction of the excitation. In this experiment, the flow rate was set to 0.3 L/min.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(1) The thrombus formation time was 77 min without excitation and 133 min with excitation, which was 1.7 times longer. (2) The results showed no difference between (280 Hz, 3 μm) and (50 Hz, 16 μm) circular orbital excitations, and no directional difference, with thrombus formation of 2.5 times longer under all conditions than that without excitation.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In the case of simple reciprocating excitation, the time was approximately 1.2 times longer. This indicated that the circular orbital excitation is more effective.</jats:p></jats:sec>

DOI： 10.1111/aor.14443

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.14443

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Antithrombogenicity of extracorporeal membrane oxygenation (ECMO) devices, particularly oxygenators, is a current problem, with numerous studies and developments underway. However, there has been limited progress in developing methods to accurately compare the antithrombogenicity of oxygenators. Animal experiments are commonly conducted to evaluate the antithrombogenicity of devices; however, it is challenging to maintain a steady experimental environment. We propose an innovative experimental animal model to evaluate different devices in a constant experimental environment in real‐time.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This model uses two venous–arterial ECMO circuits attached to one animal (one by jugular vein and carotid artery, one by femoral vein and artery) and real‐time assessment of thrombus formation in the oxygenator by indocyanine green (ICG) fluorescence imaging. Comparison studies were conducted using three pigs: one to compare different oxygenators (MERA vs. CAPIOX) (Case 1), and two to compare antithrombotic properties of the oxygenator (QUADROX) when used under different hydrodynamic conditions (continuous flow vs. pulsatile flow) (Cases 2 and 3).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Thrombi, visualized using ICG imaging, appeared as black dots on a white background in each oxygenator. In Case 1, differences in the site of thrombus formation and rate of thrombus growth were observed in real‐time in two oxygenators. In Case 2 and 3, the thrombus region was smaller in pulsatile than in continuous conditions.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We devised an innovative experimental animal model for comparison of antithrombogenicity in ECMO circuits. This model enabled simultaneous evaluation of two different ECMO circuits under the same biological conditions and reduced the number of sacrificed experimental animals.</jats:p></jats:sec>

DOI： 10.1111/aor.14380

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.14380

記述言語：英語   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.31.90

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Mechanical Engineers  

In addition to the characteristics of soft actuators, such as flexibility and elasticity, biohybrid actuators also exhibit few distinctive functions, such as self-growth and self-healing. The previous research on biohybrid actuators has focused on culturing muscle cells and assembling them into micro-robots. These technologies are well-developed, however they lack the design and control methods found in the existing actuators that enable an appropriate performance. Therefore, we propose a simple muscle contraction model against external electrical stimulation, applying the model-based design and realizing the control of biohybrid actuators. The model comprises three sub-models—the electrical dynamic, physiological, and mechanical dynamic characteristics. The input of the model is the time-series stimulation voltage, and therefore, it can be applied to any complex stimulation waveform. The model parameters were identified with multiple square waves with different frequencies and amplitudes, based on the actual skeletal muscle of a toad. Subsequently, in the validation test, the actual muscle contraction was compared with the simulated force that was calculated using the identified parameters. Although the stimulations for the validation were different from those for the identification, the results obtained based on the model showed a good agreement with the experimental results. In addition, the optimal stimulation signal could be also calculated based on the model, to obtain the maximum net work. The findings of this study facilitate the development of model-based design and control methods for biohybrid actuators in the future, that will lead to significant development in this field.

DOI： 10.1299/jbse.22-00269

DOI： 10.1299/jbse.24-00254_references_DOI_Fle6OPD0nlS98NXe3SgFTFrLFAK

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18748/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MYU K.K.  

DOI： 10.18494/sam4134

DOI： 10.1299/jbse.23-00590_references_DOI_ECx1MmQxxsA3OBfGg7L05oT2RSl

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

Plasma skimming can exclude red blood cells from high shear regions in the gaps formed by hydrodynamic bearings in rotary blood pumps. We investigated the effect of the gap size and groove design on the plasma skimming efficiency. Spiral groove bearings (SGBs) were installed into a specially designed test rig for in vitro experiments performed using human blood. The measured gap between the ridges of the bearing and the rotor surface was 17-26 µm at a flow rate of 150 ml/min and a rotor speed of 2400 rpm. Three different patterns of SGBs were designed (SGB-0, SGB-30, and SGB-60) with various degrees of the circumferential component. The hematocrit measured by a high-speed camera was compared with the hematocrit in the circuit, and the plasma skimming efficiency for the three bearing patterns was evaluated at hematocrits of 20%, 25%, and 30%. SGB-60, which had the strongest circumferential component, provided the best plasma skimming efficiency. When the gap size was less than 20 µm, the red blood cells in the gaps between the ridges of the bearing and rotor surface reduced significantly and the efficiency became higher than 90%. The gap size had the strongest effect on producing a significant plasma skimming. The plasma skimming efficiency can be significantly improved by optimizing the bearing gap size and groove design, which facilitates the further development of SGBs for use in applications such as rotary blood pumps.

DOI： 10.1007/s10047-021-01308-x

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その他リンク： https://link.springer.com/article/10.1007/s10047-021-01308-x/fulltext.html

掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.nanoen.2022.107357

DOI： 10.2139/ssrn.4071777

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掲載種別：研究論文（学術雑誌）   出版者・発行元：World Scientific Pub Co Pte Ltd  

<jats:p> To develop a power generation system as a solution to the power supply problems of small active implantable medical devices, we proposed a new method to examine muscles using skeletal muscle contraction through electrical stimulation. Realization of the system requires data on the contraction characteristics of a part of the muscles through which blood flows; thus, a dedicated setup was built and verified using a goat. The connecting parts were attached to two points in the large muscle of the goat’s trunk; one was fixed and the other slid along the guide. The distance and force between the two points, approaching each other, were measured by contracting the muscle between the points using electrical stimulation and pulling the measurement cart. The contraction distance and force were measured simultaneously, and the dynamic work of the contraction was calculated. The muscle work occurred with almost the same time delay regardless of the load, and the work tended to be greater when the contraction force, and not the contraction distance, of the muscle was large. The setup is physiological, simple, and versatile. Our setup can potentially be used in the development of implantable power generation systems and in other related fields. </jats:p>

DOI： 10.1142/s0219519422500075

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18830/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Mechanical Engineers  

For circulation support in patients with heart disease, a miniaturized implantable ventricular assist device (VAD) is required. However, several issues such as hemolysis and miniaturization need to be addressed. The objective of this study is to develop a passive levitation system for an impeller with a large gap without active control. The large gap prevents blood damage, and passive levitation contributes to the miniaturization of the VAD. In this study, a new passive levitation system utilizing thrust and magnetic force is proposed. The thrust generated by the rotation of the impeller changes depending on the interaction between the housing geometry and impeller position, even with a large gap. Considering this characteristic, the impeller was levitated by balancing the magnetic force generated by the permanent magnets and the thrust in the axial direction. The movements in the radial and angular directions are passively supported by the restoring force and torque generated by the permanent magnets. The thrust was calculated using computational fluid dynamics, and the pump was designed such that the thrust changes according to the axial displacement of the impeller. The magnetic force generated by the permanent magnets was calculated using finite-element method 3D magnetic field analysis. In addition, the required current density flowing into the coil to rotate the impeller is calculated. The levitation of the impeller was confirmed by combining the results of the analyses. The results show that the motor torque should be improved. In conclusion, this study demonstrates the feasibility of a novel levitation system for implantable miniaturized VADs.

DOI： 10.1299/jamdsm.2022jamdsm0025

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02098/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Ovid Technologies (Wolters Kluwer Health)  

<jats:p>Acquired von Willebrand syndrome (AVWS), characterized by reduced von Willebrand factor (VWF) large multimers, has recently been implicated as the principal mechanism underlying bleeding in patients implanted with left ventricular assist devices (LVADs). Hematological severity of AVWS varies among patients, even if an identical device is implanted. We investigated whether this diversity in hematological severity is due to individual variability in VWF fragility, according to responses to incremental shear stress. Whole-blood samples were sheared at 20,000–40,000 s<jats:sup>–1</jats:sup> shear rate, an index of shear stress, using a custom-made shear stressor that could generate shear stress compatible with that produced by an LVAD. The degree of VWF large multimers degradation was evaluated using the VWF large multimer index. A significant inverse correlation was observed between the VWF large multimer index and LVAD-compatible magnitudes of shear stress: the VWF large multimer indices were 68.5 ± 18.3, 48.0 ± 13.9, 33.9 ± 12.1, 23.7 ± 7.9, and 18.7% ± 8.7% at 20,000, 25,000, 30,000, 35,000, and 40,000 s<jats:sup>–1</jats:sup> of shear rates, respectively (<jats:italic toggle="yes">P</jats:italic> < 0.0001). Furthermore, experimental VWF large multimer index values were compatible with those derived from patients with implanted LVADs (median; 28.9%). Finally, reduction in the VWF large multimer index corresponding to shear stress showed individual variation. We demonstrated that the combined use of a novel high shear stress loading device and quantitative evaluation of VWF large multimers may predict risk of bleeding before LVAD implantation.</jats:p>

DOI： 10.1097/MAT.0000000000001623

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03760/

掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

DOI： 10.1109/embc46164.2021.9629535

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：IEEE  

We have been developing an implantable power generation system that uses muscle contraction following electrical stimulation as a permanent power source for small implantable medical devices. However, if the muscle tissue is overloaded for power generation, the tissue may rupture or blood flow may be impaired. In this study, we developed a new muscle-connecting component that solves these problems. The new connection device has three rods attached to the muscle fibers, and the force exerted on the muscle fibers is converted from horizontal to vertical when the muscle contracts. We conducted simulations with a three-dimensional (3D) model, as well as pulse wave muscle measurements and in vivo tests using the actual muscle. The pulse wave in the connecting part and its downstream were optically measured from the muscle surface, and the blood flow was not obstructed. The 3D model simulations revealed that the distribution of stress was preferable compared with the case in which a rod was stuck vertically in the muscle. In the in vivo muscle tests, the metal rod and resin parts were attached to the muscle, and a load of up to approximately 9 N was applied to the connecting part. Consequently, the connecting part was stable and integrated with the muscle, and there was no damage in the muscle. Although no long-term or histological evaluations were conducted, the device may be useful because of the intramuscular power generation owing to the minimal load applied on the part connected with the muscle.

DOI： 10.1109/EMBC46164.2021.9629561

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K12748/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>Extracorporeal membrane oxygenation (ECMO) plays an important role in the coronavirus disease 2019 (COVID‐19) pandemic. Management of thrombi in ECMO is generally an important issue; especially in ECMO for COVID‐19 patients who are prone to thrombus formation, the thrombus formation in oxygenators is an unresolved issue, and it is very difficult to deal with. To prevent thromboembolic complications, it is necessary to develop a method for early thrombus detection. We developed a novel method for detailed real‐time observation of thrombi formed in oxygenators using indocyanine green (ICG) fluorescence imaging. The purpose of this study was to verify the efficacy of this novel method through animal experiments. The experiments were performed three times using three pigs equipped with veno‐arterial ECMO comprising a centrifugal pump (CAPIOX SL) and an oxygenator (QUADROX). To create thrombogenic conditions, the pump flow rate was set at 1 L/min without anticoagulation. The diluted ICG (0.025 mg/mL) was intravenously administered at a dose of 10 mL once an hour. A single dose of ICG was 0.25mg. The oxygenator was observed with both an optical detector (PDE‐neo) and the naked eye every hour after measurement initiation for a total of 8 hours. With this dose of ICG, we could observe it by fluorescence imaging for about 15 minutes. Under ICG imaging, the inside of the oxygenator was observed as a white area. A black dot suspected to be the thrombus appeared 6‐8 hours after measurement initiation. The thrombus and the black dot on ICG imaging were finely matched in terms of morphology. Thus, we succeeded in real‐time thrombus detection in an oxygenator using ICG imaging. The combined use of ICG imaging and conventional routine screening tests could compensate for each other's weaknesses and significantly improve the safety of ECMO.</jats:p>

DOI： 10.1111/aor.13999

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13999

記述言語：英語   出版者・発行元：SAGE Publications  

<jats:p> Blood pumps are often used for hemofiltration in patients with renal failure. To design effective centrifugal blood pumps for hemofiltration, it is important to suppress clogging caused by platelet aggregation. However, the optimal conditions for conducting anti-platelet aggregation tests in vitro have not yet been established. This study aimed to quantify the effect of the shear loading value and shear loading time on platelet aggregation and determine the optimal conditions for anti-platelet aggregation testing in vitro. To quantitatively evaluate platelet aggregation in terms of the negative logarithm-platelet aggregation threshold index (NL-PATI), which reflects the propensity of residual platelets to aggregate after shear loading, the following parameters were examined: blood collection method (collected from porcine vein using a syringe or collected from a slaughterhouse), type of anticoagulant (sodium citrate or heparin), shear rate, and shear time. The results showed that platelet aggregation in porcine blood increased under a high shear load applied at shear rates of approximately 20,000 s<jats:sup>−1</jats:sup> or higher for 30 s. Platelet aggregation propensity was 2–3 times higher in heparin-anticoagulated blood than in sodium citrate-anticoagulated blood. Moreover, platelet aggregation was 1.5–2 times more in blood collected from the slaughterhouse than in syringe-collected blood. Testing with an integrated shear time of 30 s or less in relation to the total blood volume may be effective for conducting in vitro circulation experiments using hemofiltration blood pumps. The conditions established in this study may be useful for hemocompatibility testing of cardiovascular devices based on NL-PATI. </jats:p>

DOI： 10.1177/03913988211020765

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その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/03913988211020765

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>Pump thrombosis induces significant complications and requires timely detection. We proposed real‐time monitoring of pump thrombus in a magnetically levitated centrifugal blood pump (mag‐lev pump) without using additional sensors, by focusing on the changes in the displacement of the pump impeller. The phase difference between the current and displacement of the impeller increases with pump thrombus. This thrombus detection method was previously evaluated through simulated circuit experiments using porcine blood. Evaluation of real‐time thrombus detection in a mag‐lev blood pump was performed using a porcine left ventricular assist circulation model in this study. Acute animal experiments were performed five times using five Japanese domestic pigs. To create thrombogenic conditions, fibrinogen coating that induces thrombus formation in a short time was applied to the inner surfaces of the pump. An inflow and an outflow cannula were inserted into the apex of the left ventricle and the carotid artery, respectively, by a minimally invasive surgical procedure that allowed minimal bleeding and hypothermia. Pump flow was maintained at 1 L/min without anticoagulation. The vibrational frequency of the impeller (70 Hz) and its vibrational amplitude (30 μm) were kept constant. The thrombus was detected based on the fact that the phase difference between the impeller displacement and input current to the magnetic bearing increases when a thrombus is formed inside a pump. The experiment was terminated when the phase difference increased by over 1° from the lowest value or when the phase difference was at the lowest value 12 hours after commencing measurements. The phase difference increased by over 1° in three cases. The pump was stopped after 12 hours in two cases. Pump thrombi were found in the pump in three cases in which the phase difference increased by over 1°. No pump thrombus was found in the other two cases in which the phase difference did not increase. We succeeded in real‐time thrombus monitoring of a mag‐lev pump in acute animal experiments.</jats:p>

DOI： 10.1111/aor.13915

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13915

出版者・発行元：ACM  

As a potential solution for solving the hemolysis problem inside the narrow bearing clearance of hydrodynamically levitated blood pumps, plasma skimming has been observed and verified with spiral groove bearings. The objective of this study is to investigate and improve the plasma skimming effect by including the consideration of the red blood cells (RBCs) flow for the hydrodynamic bearing groove shape design. We designed a test rig to imitate the shear flow conditions inside the hydrodynamic bearing clearance. By visualizing RBCs inside the bearing clearance, plasma skimming efficiency with three different designs of groove shapes, referring to PlateA, PlateB, and PlateC, were evaluated and compared under a clearance size of 25 μm, a rotational speed of 2400 rpm, and a flow rate of 150 ml/min conditions. The flow of RBCs inside the clearance was photographed by a high-speed camera with a magnification lens. The plasma skimming efficiency was evaluated by comparing the measured hematocrit using the camera and the measured hematocrit of blood in the circuit. The in vitro blood tests were repeated three times for each designed groove shape with 1%-5% hematocrit human blood as the working fluid. The Student's t-test result of plasma skimming efficiency among three designed shapes showed that there was a significant difference between PlateA and PlateC at hematocrit of 5%, 4%, 3% and 2%, respectively. It is testified that the groove shapes of hydrodynamic bearings have a significant influence on the plasma skimming effect occurring in the bearing clearance.

DOI： 10.1145/3460238.3460256

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/aor.13743

Web of Science

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13743

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>The use of contactless support technology for the impeller has led to an increase in the durability of ventricular assist devices (VADs), and these have been in clinical use worldwide. However, pump thrombosis and stroke are still issues to be solved. We have developed a method for detecting the thrombosis in a magnetically levitated blood pump without the need for additional sensors or other equipment. In the proposed method, a sinusoidal current is applied to the electromagnets used for the magnetic bearing, resulting in vibration of the impeller. The phase difference between the current and displacement of the impeller increases with pump thrombosis. First, we describe the principle by which the pump thrombosis is detected. Pump thrombosis reduces the narrowest fluid gap in the pump and this gives rise to a change in the phase difference. Second, we report on experiments in which we changed the narrowest fluid gap using oriented polypropylene tape and showed that decreasing the narrowest fluid gap resulted in an increase in phase difference. For these experiments, the measurements were repeated three times for each condition. Third, we examine the relationship between the pump thrombosis and the phase difference evaluated by observations of the underside of the impeller when operating the pump with porcine blood. Since light was unable to penetrate the blood layer, the erythrocytes were removed for this observation. Only one observation was made. The results showed the phase difference rapidly increased at the same moment when the pump thrombosis was observed. This implies the proposed method has the potential to detect the early stages of pump thrombosis. Finally, in vitro experiments to detect thrombosis when using whole porcine blood in the pump were conducted. The experiment was carried out five times. To intentionally form a thrombus inside the pump, the activated clotting time was controlled to be less than 200 s. In every case, the phase difference increased by more than one degree after tens of minutes. Then, the pump was disassembled and a small amount of pump thrombosis was observed. We conclude that real‐time diagnosis of pump thrombosis may be realized by measuring the phase difference without the need for additional sensors.</jats:p>

DOI： 10.1111/aor.13632

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13632

記述言語：日本語   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.27.302

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Mechanical Engineers  

We propose an energy harvesting device driven by the contraction of an electrically-stimulated skeletal muscle that can be used as an alternative to batteries for implantable medical devices. In order to realize a durable generator, this device has a contactless plucking mechanism comprising parallel leaf springs and magnets, with which the generator can be driven without friction. By utilizing this mechanism, the generator can be driven not only in the contraction phase of the muscle, but also during relaxation. For the design we optimized the stiffness of the springs, the gap between the magnets, and the magnetic circuit in order to maximize the power generated. The power generated by a prototype in a benchtop experiment was 35.8 μW, which is sufficient to drive an implantable medical device. Furthermore, we evaluated the power generated in an ex-vivo experiment in which the gastrocnemius muscle of a toad weighing 193.4 g was electrically stimulated to drive the mechanism. In this experiment, 18.1 μW of power was generated from a skeletal muscle weighing only 3.5 g. It was also confirmed that the power generated exceeded the power required to electrically stimulate the skeletal muscle. The results showed the feasibility of an energy harvesting system utilizing the proposed mechanism.

DOI： 10.1299/jamdsm.2019jamdsm0068

DOI： 10.1299/jbse.22-00269_references_DOI_OzYGB6YcDESOXcyUNNQH973tDy7

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18830/

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>Mechanical circulatory support devices have been used clinically for patients with heart failure for over 10 years. However, thrombus formation inside blood pumps remains a risk to patient life, causing pump failure and contributing to neurological damage through embolization. In this article, we propose a method for preventing thrombus formation by applying vibrational excitation to the impeller. We evaluate the ability of this method to enhance the antithrombogenic properties of a magnetically levitated centrifugal blood pump and ensure that the impeller vibration does not cause undue hemolysis. First, 3 vibrational conditions were compared using an isolated pump without a mock circulation loop; the vibrational excitation frequencies and amplitudes for the impeller were set to (a) 0 Hz‐0 μm, (b) 70 Hz‐10 μm, and (c) 300 Hz‐2.5 μm. The motor torque was measured to detect thrombus formation and obtain blood coagulation time by calculating the derivative of the torque. Upon thrombus detection, the pump was stopped and thrombi size were evaluated. The results showed an increase in the blood coagulation time and a decrease in the rate of thrombus formation in pumps with the impeller vibration. Second, an in vitro hemolysis test was performed for each vibrational condition to determine the effect of impeller vibration on hemolysis. The results revealed that there was no significant difference in hemolysis levels between each condition. Finally, the selected vibration based on the above test results and the non‐vibration as control were compared to investigate antithrombogenic properties under the continuous flow condition. The blood coagulation time and thrombi size were investigated. As a result, vibrational excitation of the impeller at a frequency of 300 Hz and amplitude of 2.5 μm was found to significantly lengthen clotting time, decreasing the rate of pump thrombus compared to the non‐vibration condition. We indicate the potential of impeller vibration as a novel mechanical antithrombogenic mechanism for rotary blood pumps.</jats:p>

DOI： 10.1111/aor.13541

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記述言語：日本語   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.27.188

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications  

<jats:p> Ventricular assist devices assist in blood circulation and form a crucial component of artificial hearts. While it is important to measure parameters such as the flow rate, pressure head and viscosity of the blood, implanting additional devices to do such measurements is inadvisable. To this end, we demonstrate the adaptation of a ventricular assist device for the purpose of measuring blood viscosity. Such an approach eliminates the need for additional dedicated viscometers in artificial hearts. In the proposed method, the blood viscosity is measured by applying radial vibrational excitation to the impeller in a ventricular assist device using its magnetic levitation system. During the measurement, blood is exposed to a combination of a low shear rate (≈100/s) generated by the radial vibration of the impeller and a high shear rate (>10,000/s) generated by the impeller’s rotation. The apparent viscosity of blood depends on the shear rate, so we determined which shear rate was the dominant one in the proposed method. The measurement results showed that the viscosity measured by the proposed method was in good agreement with the reference viscosity measured with a high shear rate. The mean absolute deviation in the measurements using the proposed method and those obtained using a concentric cylindrical viscometer at a high shear rate was 0.12 mPa s for four samples of porcine blood, with viscosities ranging from 2.32 to 2.75 mPa s. </jats:p>

DOI： 10.1177/0954411919838738

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Mechanical Engineers  

Throwing an object by a powered robotic system is an effective way for object manipulation in long distance. The focus of the throwing is on the accuracy of the landing point with respect to model uncertainties or disturbances. A robust controller is often designed, however, the motion will be finished before the controller produces its effects because throwing is fast and highly dynamic. Moreover, the robot system sometimes has zero adjustment error in the initial position on its joint angle. This error cannot be overcome by a robust controller. So far, we have proposed a dynamic sensitivity analysis method of throwing for a feed-forward controlled manipulator. The sensitivity of the landing point with respect to zero adjustment error has been calculated, and robust throwing with small sensitivity has been designed. In this paper, the conventional method is applied to a feed-forward/back controlled manipulator in the real world, and evaluations are executed by using a prototyped three-link manipulator. The effectiveness of the proposed method is evaluated based on the sensitivity and variance of the landing point, and a robust throwing with small sensitivity is designed.

DOI： 10.1299/mej.17-00442

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.sna.2016.10.027

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.24.131

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記述言語：英語  

DOI： 10.1063/1.4953653

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications  

<jats:p> An implantable power generation system driven by muscle contractions for supplying power to active implantable medical devices, such as pacemakers and neurostimulators, is proposed. In this system, a muscle is intentionally contracted by an electrical stimulation in accordance with the demands of the active implantable medical device for electrical power. The proposed system, which comprises a small electromagnetic induction generator, electrodes with an electrical circuit for stimulation and a transmission device to convert the linear motion of the muscle contractions into rotational motion for the magneto rotor, generates electrical energy. In an ex vivo demonstration using the gastrocnemius muscle of a toad, which was 28 mm in length and weighed 1.3 g, the electrical energy generated by the prototype exceeded the energy consumed for electrical stimulation, with the net power being 111 µW. It was demonstrated that the proposed implantable power generation system has the potential to replace implantable batteries for active implantable medical devices. </jats:p>

DOI： 10.1177/0954411916638889

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Mechanical Engineers  

Oil film bearings are applied for large rotational machineries owing to their large load capacity and damping effect. However, a swirling flow of the lubricant induces self-excitation at high rotational speed. The stability margin changes during many years due to the mechanical wear and fatigue. Thus, stability diagnosis of the rotor-oil film bearing systems is required. In this paper, we focus on the onset rotational speed of self-excitation as a stability index. Firstly, a 2-DOF rotor-oil film bearing model is constructed using the mode synthesis method and Bently/Muszynska model for oil film bearings. Then, an estimation method of the onset rotational speed using frequency responses measured at lower rotational speeds than the onset one is derived from the model. Finally, a test rig consisting of a rotor supported with two oil film bearings and a radial magnetic bearing is fabricated and frequency response functions with forward circular excitation are measured by utilizing the magnetic bearing. The experimental result shows that the predicted onset rotational speed using the frequency responses at 30, 40 and 50 rps is 60.4 rps, and the error between the estimated and measured onset rotational speeds is less than 4 rps (6%).

DOI： 10.1299/transjsme.15-00500

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記述言語：英語  

DOI： 10.1109/LMAG.2015.2508004

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記述言語：英語   出版者・発行元：Japan Society of Mechanical Engineers  

DOI： 10.1299/jamdsm.2015jamdsm0046

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>Controlling the flow rate in an implantable rotary blood pump based on the physiological demand made by the body is important. Even though various methods to estimate the flow rate without using a flow meter have been proposed, no adequate method for measuring the blood viscosity, which is necessary for an accurate estimate of the flow rate, without using additional sensors or mechanisms in a noninvasive way, has yet been realized. We have developed a sensorless method for measuring viscosity in magnetically levitated rotary blood pumps, which requires no additional sensors or mechanisms. By applying vibrational excitation to the impeller using a magnetic bearing, we measured the viscosity of the working fluid by measuring the phase difference between the current in the magnetic bearing and the displacement of the impeller. The measured viscosity showed a high correlation (<jats:styled-content style="fixed-case"><jats:italic>R</jats:italic><jats:sup>2</jats:sup></jats:styled-content> > 0.992) with respect to a reference viscosity. The mean absolute deviation of the measured viscosity was 0.12 mPa·s for several working fluids with viscosities ranging from 1.18 to 5.12 mPa·s. The proposed sensorless measurement method has the possibility of being utilized for estimating flow rate.</jats:p>

DOI： 10.1111/aor.12440

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18494/SAM.2015.1068

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.precisioneng.2014.10.012

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   出版者・発行元：The Japan Society of Applied Electromagnetics and Mechanics  

In order to avoid the drive line infection of implantable devices and the surgical treatment for battery replacement, an intravascular micro turbine generator using blood flow, has been proposed and developed. The micro generator consisting of a micro turbine, a magnetic fluid (MF) seal, a stent, and an electrical generator is inserted by catheter into a descending aorta, which is able to reduce the invasiveness to patients. The experimental results using a prototype generator placed in a mock circuit loop showed that the resisting pressure of the MF seal was more than 25 kPa at 2,000 rpm and the generated power was 0.12 mW under a pulsatile flow condition.

DOI： 10.14243/jsaem.23.151

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その他リンク： https://jlc.jst.go.jp/DN/JLC/20011222352?from=CiNii

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：公益社団法人 精密工学会  

In the field of centrifugal blood pumps, contactless support of the impeller by a magnetic bearing has been identified as a promising method for reducing blood damage and to enhance durability. We developed a novel blood pump both with a two-degree-of-freedom radial controlled magnetic bearing and a contactless torque transmission mechanism placed in the outer side of a permanent magnet-free impeller. The proposed mechanism can realize not only a smooth secondary flow in the pump, but also a cost effective pump head. The prototype magnetic bearing and magnetic coupling succeeded in the stable levitation and contactless rotation of the impeller both in air and water. The pump can provide a flow rate of 5L/min against a head pressure of more than 350 mmHg. In order to simulate the ventricular assist condition, the prototype pump was connected to a mock systemic circulatory loop including a pulsatile pump. The dynamic stability of the impeller was experimentally verified when the pulsatile pressure was applied during the left ventricular assist.

DOI： 10.2493/jjspe.80.81

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1177/0954411911422842

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：公益社団法人 精密工学会  

A disposable magnetically levitated centrifugal blood pump, which aims to be used for from a few days to a few months, has been developed. An impeller is levitated and rotated without contact using a two-degree-of-freedom radial magnetic bearing and a magnetic coupling. Due to 'out-of-step' of the magnetic coupling caused by its insufficient transmittable torque, a previous prototype pump could not yield the required pressure-flow characteristics of 5 L/min against 106 kPa (800 mmHg). The magnetic coupling was redesigned in order to increase the transmittable torque. The stability of the impeller levitation against impact was evaluated through a base excitation test simulating animal experiment and practical use. Applying an impulse excitation of an acceleration of 200 m/s², the impeller could keep contactless levitation both in the controlled direction and in the passively supported directions. Finally, the animal experiments for one to two weeks showed that no damage and no thrombus formation were found in the pump heads.

DOI： 10.2493/jjspe.76.1064

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DOI： 10.1111/j.1525-1594.2010.01107.x

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DOI： 10.1111/j.1525-1594.2009.00957.x

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DOI： 10.1111/j.1525-1594.2009.00900.x

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DOI： 10.1111/j.1525-1594.2006.00332.x

DOI： 10.1111/j.1525-1594.2009.00817.x_references_DOI_FYcLOoBEqPCevFvk6XGahSAVS3l

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記述言語：日本語   出版者・発行元：The Society of Life Support Engineering  

DOI： 10.5136/lifesupport.18.89

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記述言語：英語  

DOI： 10.1111/j.1525-1594.2006.00229.x

DOI： 10.1177/0391398820984485_references_DOI_FhiFSA12TqMGZdroxiKpFy0WIdy

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：IEEE  

DOI： 10.1109/bmeicon64021.2024.10896336

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：IEEE  

DOI： 10.1109/powermems63147.2024.10814518

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

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記述言語：英語   出版者・発行元：IEEE  

Plasma skimming in spiral groove bearings (SGBs) has the potential to reduce hemolysis by guiding the red blood cells to escape from the narrow ridge gap with high shear stress force, to the larger groove gap. In our previous study, we designed an optimal SGB-PS that aims to improve plasma skimming inside the bearing gaps and verified its effectiveness under whole blood conditions up to 40% hematocrit level. This study extends our work by evaluating the load-carrying capacity of the optimized SGB design. We first analyzed the load-carrying capacity numerically by calculating the hydrodynamic force based on the Reynolds equation. Then we designed and manufactured an experimental device to measure the generated hydrodynamic force under comparable conditions. Our results indicate that the hydrodynamic force generated by the SGB-PS meets the requirements for our hydrodynamically levitated rotary blood pump and aligns well with our numerical analysis. This research contributes to improving the performance of the SGB for hemolysis resistance in hydrodynamically levitated rotary blood pumps.

DOI： 10.1109/embc53108.2024.10781874

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2023.2p1-g17

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

本研究では人工心臓に用いる磁気浮上機構を，血栓の検出および予防システムとして利用する．具体的には，血液吐出用インペラを円軌道状に強制変位加振する．このとき，血栓形成時のインペラダイナミクスの変化を捉え，血栓検出センサへ応用する．また，この加振により，血栓形成初期段階の血液成分付着を阻止し，血栓を予防する．この制御の効果を検証するため，ブタ血液を充填した模擬循環回路を用い，実証した．

DOI： 10.11522/pscjspe.2023s.0_283

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

骨格筋と人工骨格からなるバイオアクチュエータは，自己成長，自己修復等の特徴を有する。本研究ではバイオアクチュエータの工学的応用を目指し，筋疲労を考慮した筋収縮モデルの構築，および骨格筋のモデルベース設計法を提案する。実験ではカエル腓腹筋の収縮応答を測定し，骨格筋の長さ等とモデルパラメータの関係を実験的に求め，所望の仕様を満たす骨格筋を設計し，カエルの筋肉で妥当性を検証した。

DOI： 10.11522/pscjspe.2023s.0_507

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2023.1p1-h13

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記述言語：日本語   出版者・発行元：IEEE  

DOI： 10.1109/wpw54272.2022.9901340

DOI： 10.14243/jsaem.31.90_references_DOI_L7pundJ3wzXns0nv22NE06H0ZzJ

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2022.2p2-n01

DOI： 10.1299/jbse.24-00017_references_DOI_Iu1XAaqcsDvKrv1AZirDTnFWEg6

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

本研究では人工心臓用の磁気浮上アクチュエータを単なる浮上機構としてだけでなく，患者の拍動や疾患状態をセンシング可能なスマートアクチュエータとして利用する．具体的には磁気浮上系に構成した外乱オブザーバによりインペラに作用する流体力を推定し，リアルタイムで疾患心臓の拍動を推定可能とした．さらに，繰返し制御器を用いたモータの心拍同期制御系を設計し，推定した拍動に同期する流量制御を実現した．

DOI： 10.11522/pscjspe.2022s.0_676

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

人工心臓用インペラの支持に動圧軸受や磁気軸受が利用されるが，狭い流体隙間での血液損傷や，アクティブ制御システムの故障が懸念される．本研究では，推力と磁力を併用することで500 µm以上の流体隙間を有し，かつ完全パッシブ浮上可能な軸流血液ポンプを開発する．数値流体力学解析と磁場解析により回転以外の5自由度が正剛性となる浮上機構を設計し，実験により10,000 rpm，1.5 L/minにおいて軸方向のパッシブ浮上を示した．

DOI： 10.11522/pscjspe.2022s.0_798

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出版者・発行元：The Korean Society of Neurogastroenterology and Motility  

Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors.The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy.

DOI： 10.5056/jnm20135

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmedmc.2021.542

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2021.1p3-j04

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2021.1p3-g04

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

【目的】ECMOは循環、呼吸不全に対し使用されるが、回路内に形成される血栓が塞栓症や人工肺ガス交換能低下などの原因となり問題である。本研究ではインドシアニングリーン(ICG)を用いた人工肺のリアルタイム血栓検出法を模擬回路実験、急性動物実験で検証した。

【方法】ICGは血液中の蛋白質と結合し、赤外線光(750-800nm波長)を吸収し、類似波長の光を発する特性を持つ。この波長領域の光はヘモグロビンや水への吸収が小さいため、分光感度が高く、血液内の観察に有用である。遠心ポンプ、人工肺を含む回路を作成し模擬回路実験ではブタ血液を循環させ、急性動物実験ではブタに体外循環回路を装着し検証した。肉眼で観察しながら、ICGを投与し赤外線カメラシステムで観察した。循環停止後、血液を生食で置換し人工肺内の血栓を観察し、さらに人工肺を分解し内部を観察した。

【結果】ICGを投与したところ人工肺内の血液より発する蛍光を背景に黒色の領域として血栓が検出された。検出した血栓は目視での観察は難しく、生食置換後に人工肺で観察できた血栓と一致していた。

【結語】ICGにより人工肺内に形成された血栓が検出可能であった。検出した血栓はハウジング面に形成された血栓であり、塞栓症との関連性が示唆された。血栓をリアルタイムに検出することは血栓の早期検出、抗凝固療法の適正化に有用である。将来的には遠隔モニタリングやデバイスの抗血栓性評価への応用も期待できる。

DOI： 10.11239/jsmbe.annual59.579

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記述言語：英語   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.29.72

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I031409402

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

植込型医療機器の代替電源として，電気刺激によって骨格筋を収縮させ，その力学的エネルギーを発電機によって電気エネルギーに変換する体内エナジーハーベスティングを提案している．本研究では，骨格筋を電気刺激した際の消費電力も考慮した正味の電力を向上させるため，電気刺激の周波数と同期して骨格筋が振動する現象である不完全強縮を利用し，その収縮運動に合わせた発電機構の設計，製作を行ったのでこれを報告する．

DOI： 10.11522/pscjspe.2021a.0_279

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2021.1p1-m12

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09969/

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記述言語：日本語   出版者・発行元：一般社団法人 日本消化器内視鏡学会 関東支部  

DOI： 10.11641/pde.97.1_66

DOI： 10.7888/juoeh.43.363_references_DOI_ULo7m6YEEb702jil3LHVRFGsztG

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その他リンク： https://search.jamas.or.jp/link/ui/2021104126

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmeiip.2020.2a04

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記述言語：英語   出版者・発行元：日本AEM学会  

DOI： 10.14243/jsaem.28.271

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I031269025

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2020.2a1-p09

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記述言語：英語   出版者・発行元：The Japan Society of Mechanical Engineers  

Energy harvesting from human motion is expected to the energy source for wearable devices. Although the energy density of human motion is high, the frequency of it is a few Hz, which does not match the conventional energy harvester. Due to this, the size of harvester tends to become large in order to get high output. This paper presents an electrostatic induction energy harvester which can generate high power at low frequency in order to power the mouthguard type sensor. To embed into the mouthguard type sensor, the total thickness of the harvester should be less than 0.2 mm to reduce the discomfort. Furthermore, the final goal of power generated of the harvester was set to a few tens of μW. The proposed harvester consists of electrets that can hold a quasipermanent charge on its surface, dielectric elastomers and electrodes. The mechanical energy applied by the biting force is converted to electrical energy by electrostatic induction. The parametric study of the harvester based on the equivalent circuit model was conducted to maximize the power generated. According to the calculation results, the harvester can achieve 22.7 μW with a load resistance of 570 MΩ, which met the requirements for the mouthguard type sensors. The fabrication and evaluation of the harvester based on the calculation results will be conducted in the future work.

DOI： 10.1299/jsmeintmovic.2020.15.10082

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出版者・発行元：Science Impact, Ltd.  

<jats:p>Heart disease is the leading cause of death in men and women around the world and it is a significant problem that requires remedy. Heart failure is where the heart is not pumping blood around the body as effectively as it should. Importantly, heart failure does not mean that the heart
has stopped working, but it does require support in order to get it working better. Over the past few decades, there have been many innovations to help address the problems with heart failure, including developing ventricular assist devices (VADs). A VAD is a mechanical pump that is placed
inside the body to support heart function and blood flow in heart patients. It works by taking blood from a lower chamber in the heart and pumping it to the body and vital organs, in the same way that a healthy heart would. Dr Wataru Hijikata is an expert in mechanical engineering and technology
with a focus on healthcare outcomes. He explains that the first generation of VADs was a pulsatile flow type, but because of the complicated mechanical structure, the size of them was large and they had low durability. He notes that the second generation VAD was a continuous flow type. Because
the blood flow was generated by the rotation of an impeller, the mechanical structure was simple and the size was small. However, the bearings to support the rotating impeller led to low durability. 'Third generation VADs are continuous flow types with contactless support of the impeller by
magnetic bearing or hydrodynamic bearings,' Hijikata outlines. Owing to the contactless support technology, the durability of VADs has been enhanced and the size of the device is small. 'However, while there has been significant progress over the years, VADs are still far from perfect and
there is much room for improvement,' he concludes. With that in mind, a team of researchers based at the Department of Mechanical Engineering in the Tokyo Institute of Technology, Japan, is investigating a means of improving VADs.</jats:p>

DOI： 10.21820/23987073.2019.10.70

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04909/

出版者・発行元：Springer Science and Business Media LLC  

In Japan, the prevalence of constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) diagnosed by the Rome III criteria is unclear, as are the demographic profile, quality of life (QOL), and habits of persons with IBS-C or FC.We performed an internet survey of constipation. After extracting 3000 persons fitting the composition of the general Japanese population, we investigated demographic factors, lifestyle, defecation, and laxatives. IBS-C and FC were diagnosed by Rome III criteria. Respondents also completed the Japanese IBS severity index (IBS-SI-J), Japanese IBS QOL scale (IBS-QOL-J), SF-8, Hospital Anxiety and Depression Scale (HADS), and Japanese Health Practice Index (JHPI).There were 262 respondents with FC (8.73%) [73 men and 189 women; mean age: 49.8 ± 13.1 years; mean body mass index (BMI): 21.0 ± 3.3 g/mIn Japan, among the population of under 70 years old, the prevalence of IBS-C and FC (Rome III criteria) was 4.97% and 8.76%, respectively. IBS-C caused more severe symptoms than FC, resulting in impairment of QOL.

DOI： 10.1007/s00535-019-01611-8

DOI： 10.3164/jcbn.19-118_references_DOI_3Qs0sj3JMTlYBZhhgQJHSbl67ss

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その他リンク： http://link.springer.com/article/10.1007/s00535-019-01611-8/fulltext.html

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記述言語：英語   出版者・発行元：IEEE  

We propose an energy harvesting device driven by a contraction of an electrically-stimulated skeletal muscle for an alternative battery of implantable medical devices. In order to realize a durable generator, we proposed a contactless plucking mechanism utilizing parallel leaf springs and magnets, with which the generator can be driven without friction. By utilizing this mechanism, the generator can be driven not only in a contraction phase, but also a relaxant phase. We optimized the stiffness of the parallel leaf springs, air gap between the magnets, and magnetic circuit in order to maximize generated power of the generator. The generated power of the prototype in nonliving environment was evaluated. The result showed the protype could achieve 35.8 μW, the value of which is enough to drive the implantable medical devices. Finally, the generated power was evaluated in the ex-vivo experiment using a gastrocnemius muscle of a toad with a weight of 193.4 g. In this experiment, the generator achieved 18.1 μW from only 3.5 g of the skeletal muscle. Also, we confirmed that the generated power exceeded the power consumption of the electrical stimulation on the skeletal muscle. Hence, we concluded the results showed the feasibility of the energy harvesting system with proposed mechanism.

DOI： 10.1109/EMBC.2019.8856414

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記述言語：英語   出版者・発行元：IEEE  

Mouthguard type sensors have been developed to monitor the healthcare-related information, which is expected to be used for pre-illness and preventive medicine. However, a method for supplying the power to these sensors is still an issue to be solved. In this paper, we propose an electrostatic oral cavity generator driven by occlusal force to supply the power for mouthguard type sensors. The proposed generator is a sheet form and consists of the lamination of the electret, dielectric elastomer and copper electrode. In this paper, we estimated the power generation with a piezoelectric generator and the proposed electrostatic generator. Then, the generators were designed and fabricated. The generated power of the prototype electrostatic generator was 18.0 μW. It was about 560 times larger than that of a piezoelectric generator with the area equivalent to four pairs of molars. Although the generated power was still smaller than the required power to drive the mouthguard sensor, we considered they can be comparable with each other by optimizing the design parameters of the generator.

DOI： 10.1109/EMBC.2019.8856933

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記述言語：英語   出版者・発行元：IEEE  

Plasma skimming is the phenomenon whereby the discharge hematocrit is lower than feed hematocrit naturally occurring in the microvessels with Poiseuille flow. It has been studied in Poiseuille flow extensively. Besides, plasma skimming has also been observed and investigated in blood pumps due to its potential to prevent hemolysis by skimming blood cells out of the small gap. However, whether plasma skimming occurs in blood pumps with whole blood has not been verified. Additionally, the independent influence of rotational speed and gap size has not been clarified. Therefore, in order to lay the foundation of applying plasma skimming to the development of blood pumps and also investigate the influence of rotational speed and gap size on plasma skimming respectively, we designed a simplified geometric device which not only imitates the flow inside clearances of blood pumps, but also provides different rotational speed and gap size conditions. We first conducted the verification tests of plasma skimming using whole blood with an initial hematocrit of 44% and the gap size was varied from 10 μm to 240 μm with 10 μm interval. The plasma skimming was verified occurring when the gap was less than 70 μm at a rotational speed of 800 rpm. Since plasma skimming was confirmed, we employed 30% hematocrit blood and performed the following tests to evaluate the influence of rotational speed of 600 rpm, 700 rpm, and 800 rpm respectively. As a result, the hematocrit of sampled blood declined as the rotational speed increased from 600 rpm to 800 rpm. And there was the lowest hematocrit of 16% when the gap was adjusted to 50 μm gap size at 800 rpm. This study further promotes the possibility of applying plasma skimming to the blood pumps with higher hemocapability.

DOI： 10.1109/EMBC.2019.8857735

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmemovic.2019.16.b302

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmeiip.2019.1d07

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   出版者・発行元：IEEE  

Thrombus is one of the major problems in ventricular assist devices (VADs). However, method for detecting thrombus in early stage has not been established yet. In this study, we propose an intelligent function that the VAD itself can detect thrombus automatically and alert it to medical staffs. In the proposed method, thrombus formation inside a blood pump is detected by monitoring blood viscosity. This viscosity measurement is performed by using magnetic levitation system for the impeller. Hence, it can be implemented without any additional sensors or mechanisms in principle. For verification of the method, at first, we visualized inside of the pump during thrombus formation with measuring blood viscosity by using erythrocytes removed porcine blood. The result showed that the viscosity of the blood increased as blood coagulation progressed. Then, we conducted in vitro principle verification experiments with three different whole porcine blood. In all experiments, the measured blood viscosity increased and small thrombus was observed inside the pump. From these results, we confirmed that the proposed method has a possibility to detect and predict the thrombus in early stage.

DOI： 10.1109/EMBC.2018.8513137

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記述言語：日本語   出版者・発行元：一般社団法人 日本内科学会  

79歳，男性．皮膚搔痒や腹水が出現し前医を受診した．好酸球増多症候群が疑われ，ステロイド全身投与で症状は改善した．5年後に大量心膜液貯留を指摘され，当院に入院した．末梢血好酸球増加，血清IgE, IgG4高値を認めるも，心膜液中に形質細胞や好酸球の増加はなし．尿閉と性腺機能低下所見から，肥大を伴わない非特異的前立腺炎を同定．同部組織診でIgG4陽性形質細胞浸潤があり，IgG4関連疾患と診断した．IgG4関連心膜炎は慢性の経過をとるが，診断時，既に収縮性心膜炎に至り，予後不良であることが多く，注意を要する．

DOI： 10.2169/naika.107.1357

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I029166220

記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2018.2a2-e15

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2018.2p2-e11

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記述言語：英語   出版者・発行元：IEEE  

We propose a contactless energy harvesting system driven by the contraction of an electrically-stimulated skeletal muscle to be used to supply electrical energy to implantable medical devices. In order to realize a durable generator, the one proposed here has a contactless clutch mechanism with parallel leaf springs, with which the generator can be driven without friction. In this system, the muscle connected to the parallel leaf spring is intentionally contracted by electrical stimulation. The generator can be driven not only in the contraction phase of the muscle, but also relaxation phase. The result an evaluation showed that the prototype could generate 26.1 $\mu \mathrm{W}$ with an efficiency of 13.7%. Finally, we conducted an animal experiment using the gastrocnemius muscle of a toad with a weighing of200 g The generator was driven in the contraction phase generating 1.37 $\mu \mathrm{W}$ of power from the energy supplied by the muscle.

DOI： 10.1109/EMBC.2018.8513105

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記述言語：英語   出版者・発行元：IEEE  

An artificial heart system is clinically used for the blood circulation of the heart failure patient. The power of it is supplied via a drive line from the outside of the body. In order to eliminate the drive line from the patient, we propose a wireless poser transfer system with magnetic resonant coupling. The system will be placed inside the room and track the motion of the patient with a receiver coil. According to the information of patient’s motion, the position and posture of a movable transmitter coil and a repeater coil are actively controlled in order to keep the high transfer efficiency. In this study, we have developed a real-time calculation algorithm to obtain the optimal coil positions and postures. Then the calculation time and effectiveness of the proposed algorithm were evaluated.

DOI： 10.1109/WPT.2018.8639256

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記述言語：英語  

Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). The phospholipase A(2) (PLA(2)) superfamily consists of a large number of members that specifically catalyse the hydrolysis of phospholipids at a particular position. Here we show that the CM-II isoform of secreted PLA(2) obtained from Naja mossambica mossambica snake venom (CM-II-sPLA(2)) possesses potent virucidal (neutralising) activity against HCV, DENV and JEV, with 50% inhibitory concentrations (IC50) of 0.036, 0.31 and 1.34 ng/ ml, respectively. In contrast, the IC50 values of CM-II-sPLA(2) against viruses that bud through the PM (Sindbis virus, influenza virus and Sendai virus) or trans-Golgi network (TGN) (herpes simplex virus) were > 10,000 ng/ml. Moreover, the 50% cytotoxic (CC50) and haemolytic (HC50) concentrations of CMII- sPLA(2) were > 10,000 ng/ml, implying that CM-II-sPLA(2) did not significantly damage the PM. These results suggest that CM-II-sPLA(2) and its derivatives are good candidates for the development of broadspectrum antiviral drugs that target viral envelope lipid bilayers derived from the ER membrane.

DOI： 10.1038/s41598-017-16130-w

DOI： 10.1016/j.toxicon.2020.12.007_references_DOI_GswaWZLQkOaME1nNCIvQj3wD3Mb

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その他リンク： https://www.nature.com/articles/s41598-017-16130-w

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出版者・発行元：Trans Tech Publications, Ltd.  

<jats:p>Proton beam writing was carried out into high purity semi-insulating 4H-SiC bulk substrates. Luminescent defects created in the SiC by proton beam writing using 1.7 MeV-proton micro beams were investigated at room temperature using confocal laser scanning microscope. As a result, photoluminescence peak around 900 nm associated with silicon vacancy was observed for the irradiated SiC without post implantation process such as annealing. The overall depth profile of photon counts detected from irradiated areas is in good agreement with simulated vacancy depth profile. This suggests that silicon vacancy can be applied to ion tracking detector. In addition, since silicon vacancy is known as single photon source of which spins can be controlled at RT, PBW is expected to be a useful tool to fabricate spin qubits.</jats:p>

DOI： 10.4028/www.scientific.net/msf.897.233

DOI： 10.1088/1361-6463/aad0ec_references_DOI_SMgcS7E0tdWAszyxFQufHPiznnJ

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H03967/

記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

<p>The results of conventional researches have concluded that a human motion is generated by torque change minimization algorithm. It requires information of both initial and final position (Point-to-point control), while human motion sometimes does not have information of the final position in the real world. In this paper, we propose an online torque change minimization algorithm. Human motions are measured by a motion capture system, and it is shown that human motion has small torque change. The proposed method is applied to the same motion and the effectiveness of the proposed method is evaluated. Finally, the proposed method is also applied to experiments of a two-link manipulator.</p>

DOI： 10.1299/jsmermd.2017.1A1-N11

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

<p>Free-throw in basketball is extremely dynamic and sensitive to the error of the joint angle through the motion. The purpose of this research is to design a trajectory which is robust against the initial error of the joints using inverse dynamics analysis and sensitivity analysis of motion capture data of free-throw. For those analyses, the dominant joint angle for free-throw is identified. The free-throw data of some participants are acquired, and they are evaluated and classified as novice or expert. The sensitivity of the experts shows small value comparing novice one, and a trajectory which has lower sensitivity is designed for the novice.</p>

DOI： 10.1299/jsmermd.2017.2A2-D01

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

<p>Throwing an object by a powered robot system is an effective way for object manipulation in long distance. The focus of the throwing is on the accuracy of the landing point with respect to model uncertainties or disturbances. So far, we have proposed a sensitivity analysis method of throwing with a feed-forward controlled manipulator, while feed-forward/back controlled one is considered in this paper. The dynamic sensitivity analysis method is developed based on the conventional method and its evaluation is executed by using a prototyped three-link manipulator. The effectiveness of the proposed method is evaluated and a robust throwing with low sensitivity is obtained that realizes small variance of the landing point.</p>

DOI： 10.1299/jsmermd.2017.1P1-H07

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmekanto.2017.23.1601

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmekanto.2017.23.1511

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

A conventional power supply method using a drive line for a ventricular assist device causes infection diseases, which decreases patient&rsquo;s quality of life and survival rate. A possible solution is to use a transcutaneous energy transmission system utilizing electromagnetic induction. However, it is necessary for the coil to be located on the body surface accurately because of short transmission distance. In order to avoid infection diseases as well as increase the transmission distance, we proposed the new system utilizing magnetic resonant coupling that embedded flexible coils into clothes to transfer energy. In this paper, we evaluated the influence of the electric characteristics of the human body on the transmission efficiency by using both phantom and pork. The measured transmission efficiency with a gap of 30 mm was 67 % in phantom and 70 % in pork while that in air was 80 %.

DOI： 10.1299/jsmeiip.2017.F-04

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記述言語：英語  

DOI： 10.1109/WPT.2017.7953865

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記述言語：日本語   出版者・発行元：府中町 (広島県) : マツダ財団  

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I033176014

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2016.1a1-02a6

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記述言語：日本語   出版者・発行元：一般社団法人日本機械学会  

A sensorless noninvasive method for measuring blood viscosity has been developed for a magnetically-levitated centrifugal blood pump. The blood viscosity can be calculated from the measured phase difference between the input current to the magnetic bearing and the impeller displacement. The experimental results using porcine blood, which has a non-Newtonian property, showed the difference between the viscosity measured by a cylinder viscometer and one by the magnetic bearing was 0.3 mPa・s. In the range of 0.5 to 4.5 L/min, the variation of the measured viscosity was less than 0.2 mPa・s. The results indicate the proposed method can be applied to measure the blood viscosity for clinical use.

DOI： 10.1299/jsmeiip.2016.f-1-1

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記述言語：日本語   出版者・発行元：公益社団法人 応用物理学会  

DOI： 10.11470/jsapmeeting.2016.1.0_3548

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記述言語：日本語   出版者・発行元：日本機械学会  

identifier:oai:t2r2.star.titech.ac.jp:50303288

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記述言語：英語  

DOI： 10.1109/MEMSYS.2016.7421708

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記述言語：日本語   出版者・発行元：一般社団法人日本機械学会  

To realize a lens drive actuator in mobile camera utilizing MEMS technology, micro-pitch and multi-pole magnetization of a sintered Nd-Fe-B magnet of 500 μm in thickness was discussed in this paper. First, the Nd-Fe-B magnet was bonded on a glass substrate using polyimide adhesive to buffer the thermal stress due to the difference of their linear expansion coefficients. Secondly, some slits were processed by a dicing at an interval of 650 μm. Then, each uniformly-magnetized and divided magnet part was alternately heated by a laser beam and each heated part was reversely magnetized by the leakage flux generated from both non-heated adjacent magnets. The micro-pitch and multi-pole Nd-Fe-B magnet generated the magnetic field of 0.48 T (p-p) at a distance of 100 μm from the surface, which is about 90% of that of simulated one.

DOI： 10.1299/jsmemnm.2015.7._29pm3-pn-_1

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記述言語：日本語   出版者・発行元：一般社団法人日本機械学会  

In the rotor systems having oil film bearings and/or fluid seals, there is a possibility of fluid-induced vibration such as oil whip and oil whirl at high rotational speed. The stability analysis methods of the rotor systems are necessary, not only in the design phase but also under operation. In this study, we propose an approximate stability analysis method by utilizing the fluid force model developed by Bently and Muszynska and experimentally excited rotor responses at a low rotational speed. The proposed method enables the prediction of the onset of self-excitation. In order to evaluate the proposed method, the Hardware-In-the-Loop (HIL) simulator, which can simulates rotor vibration in real time, was constructed. From the simulation results, it became clear that the self-excitation was precisely estimated by the proposed stability analysis.

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2015._1a1-d06_1

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2015._1p1-f07_1

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記述言語：英語   出版者・発行元：一般社団法人日本機械学会  

In order to realize high-frequency and multi- dimensional laser beam focus positioning during laser beam cutting, a maglev 3-DOF lens driving actuator is developed. The objective of this paper is the design and fabrication of a compact maglev lens driving actuator which can drive the lens in both the axial and radial directions, and can be accommodated in the laser head of a conventional laser cutting machine.

DOI： 10.1299/jsmemipe.2015._MoP-40-1_

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記述言語：英語   出版者・発行元：株式会社ミュー  

DOI： 10.18494/sam.2015.1068

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmemecj.2014._j2410102-

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

レーザ穴あけ加工では，レーザの高出力化は加工速度向上に有効である．一方，焦点固定，酸素をアシストガスとした厚板加工では，レーザの高出力化に伴い，局所的な温度上昇による過剰な酸化燃焼（バーニング）を発生する問題がある．そこで，穴あけ加工時に，集光レンズを円・上下揺動し，入熱位置を分散することで，バーニングを回避しながら，レーザの初期出力を向上し，加工時間を短縮する方法を実験的に検討したので報告する．

DOI： 10.11522/pscjspe.2014a.0_681

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

体内植込み型医療機器の将来的な電源として，電気刺激による筋肉収縮を利用した体内発電システムの実現を目指している．本発表では発電機設計の基礎データを取得するため，カエルの筋肉を対象に，電圧，周波数などを変化させた矩形電圧刺激に対する筋肉の収縮特性を調査した．その結果，疲労が少なく効率の良い筋収縮を引き起こせる電気刺激の条件を明らかにした．

DOI： 10.11522/pscjspe.2014a.0_133

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

酸素をアシストガスとして用いるレーザ切断加工では，切断面に，周期的な酸化燃焼による条痕が形成される．特に厚板切断では深い条痕生成により，面粗さが悪化する．そこで，厚板切断中にレーザ焦点を高周波搖動し，積極的に細かい条痕を形成することで，面粗さを改善する手法を提案した．本報告では，厚板切断における条痕形状及び面粗さに対する，レーザ焦点揺動の振幅及び周波数の影響を評価したので報告する．

DOI： 10.11522/pscjspe.2014a.0_679

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出版者・発行元：Wiley  

<jats:sec><jats:label /><jats:p>We have studied the temperature dependence of optical transitions in dilute GaAsN alloys using photoreflectance (PR). A delocalized‐state transition is clearly observed in PR spectra while several localized‐state emission lines due to isoelectronic centers appear in photoluminescence spectra. The energy of optical transitions observed in PR spectra is in agreement with the excitonic transition energy in photoluminescence excitation spectra, clearly showing that the optical transitions in PR spectra are excitonic transitions. We analyzed the temperature dependence of the excitonic transition energies using the Bose–Einstein statistical expression, and found that even dilute alloys follow the same trend as GaAsN alloys with higher nitrogen concentrations. We discuss the coexistence of localized and delocalized states in dilute GaAsN alloys in terms of the random distribution of N atoms.</jats:p></jats:sec>

DOI： 10.1002/pssa.201300462

DOI： 10.1002/crat.202000143_references_DOI_M52BqHSFOdzDrBQgtQb6E5Yd9Hq

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24360004/

記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmeiip.2014._f-2-1-1_

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出版者・発行元：American Association for the Advancement of Science (AAAS)  

<jats:title>Soft, Selective CO Sorption</jats:title>
<jats:p>
Many industrial processes produce CO, which could be used as a chemical feedstock, but separation of CO from other gases, especially N
<jats:sub>2</jats:sub>
, is too difficult to be economically viable.
<jats:bold>
Sato
<jats:italic>et al.</jats:italic>
</jats:bold>
(p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6167" page="167" related-article-type="in-this-issue" vol="343" xlink:href="10.1126/science.1246423">167</jats:related-article>
, published online 12 December 2013) now report that a porous coordination polymer containing Cu
<jats:sup>2+</jats:sup>
ions can selectivity bind CO through serial structural changes reminiscent of allosteric effects in proteins. The separation of CO-N
<jats:sub>2</jats:sub>
mixtures can be achieved with a low input energy for CO desorption.
</jats:p>

DOI： 10.1126/science.1246423

DOI： 10.1002/chem.201602087_references_DOI_HA0Id4AFF1NA3712rUdZdGwQJt6

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22000009/

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記述言語：日本語   出版者・発行元：日本作物学会  

DOI： 10.14829/jcsproc.236.0_132

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記述言語：日本語   出版者・発行元：一般社団法人日本機械学会  

A disposable extracorporeal centrifugal blood pump utilizing a simply-structured radial controlled magnetic bearing and a torque transmission mechanism has been developed to enhance the durability of the disposable pump head and to reduce blood trauma such as hemolysis and thrombus formation. The prototype blood pump satisfied a requirement of a flow rate of 5 L/min against a head pressure of 800 mmHg. Under sinusoidal base excitation of the maximum acceleration of 9.8 m/s^2 from 10 to 200 Hz and impulse base excitation of 78.4 m/s^2 in the axial and radial directions, the impeller could levitate stably within amplitude of 35 μm in the radial direction, which was smaller than the fluid gaps of 0.3 mm. The normalized index of hemolysis of the prototype was 5.4 ± 0.8 mg/100L, which was about a half of the equivalent value of a commercialized pump having mechanical bearings (BioPump BPX-80). After in-vivo studies with calves for one to two weeks, no thrombus formation was found inside the pump heads.

DOI： 10.1299/jsmekanto.2009.15.213

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

経皮的心肺補助循環装置に使用可能な使い捨て磁気浮上遠心血液ポンプの実用化研究を進めている．本ポンプは，磁気浮上によるインペラの非接触支持により，機械的なインペラ支持機構を有する血液ポンプと比較して，耐久性の１０倍以上の向上と，低溶血，低血栓性の実現を目指している．本発表では，磁気浮上遠心血液ポンプシステムの設計，および，子牛による動物実験に適用可能な使い捨てポンプヘッドの製造方法に関して紹介する．

DOI： 10.11522/pscjspe.2009S.0.43.0

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記述言語：日本語   出版者・発行元：生体材料工学研究所年報  

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記述言語：英語   出版者・発行元：Wiley  

<jats:p><jats:bold>Abstract: </jats:bold> A magnetically levitated centrifugal blood pump (MedTech Dispo) has been developed for use in a disposable extracorporeal system. The design of the pump is intended to eliminate mechanical contact with the impeller, to facilitate a simple disposable mechanism, and to reduce the blood‐heating effects that are caused by motors and magnetic bearings. The bearing rotor attached to the impeller is suspended by a two degrees‐of‐freedom controlled radial magnetic bearing stator, which is situated outside the rotor. In the space inside the ringlike rotor, a magnetic coupling disk is placed to rotate the rotor and to ensure that the pump head is thermally isolated from the motor. In this system, the rotor can exhibit high passive stiffness due to the novel design of the closed magnetic circuits. The disposable pump head, which has a priming volume of 23 mL, consists of top and bottom housings, an impeller, and a rotor with a diameter of 50 mm. The pump can provide a head pressure of more than 300 mm Hg against a flow of 5 L/min. The normalized index of hemolysis of the MedTech Dispo is 0.0025 ± 0.0005 g/100 L at 5 L/min against 250 mm Hg. This is one‐seventh of the equivalent figure for a Bio Pump BPX‐80 (Medtronic, Inc., Minneapolis, MN, USA), which has a value of 0.0170 ± 0.0096 g/100 L. These results show that the MedTech Dispo offers high pumping performance and low blood trauma.</jats:p>

DOI： 10.1111/j.1525-1594.2008.00576.x

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記述言語：英語  

DOI： 10.1109/aim.2008.4601723

DOI： 10.1109/tmag.2015.2456338_references_DOI_4dCtw19jTRb6mLrsfta3ScNcDIw

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記述言語：日本語   出版者・発行元：東京医科歯科大学生体材料工学研究所  

null

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記述言語：日本語   出版者・発行元：自動制御連合講演会  

体内埋込式補助人工心臓では，小型，高耐久，循環に必要な流量・揚程，血液への低ダメージが求められている．本研究では，高耐久と血液への低ダメージを満たすため，２自由度制御型磁気軸受とビルトインモータを用い，成人の補助循環に必要な100mmHg, 5L/minの吐出圧力・流量を満たす，ポンプ外径55mm，高さ25mm，インペラ直径40mmの極めてコンパクトな磁気浮上式遠心血液ポンプを実現した．

DOI： 10.11511/jacc.50.0.29.0

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記述言語：日本語   出版者・発行元：自動制御連合講演会  

血液接触部が使い捨て可能な体外血液循環補助用遠心血液ポンプにおいて，インペラ支持用軸受の低耐久性や，軸受接触部での血液ダメージが問題である．本研究では，ロータが使い捨て可能な単純な磁気軸受に，繰返し制御とゼロパワー制御を併用することで，ロータ振動と電磁石発熱を低減し，回転駆動に，低発熱トルク伝達メカニズムを用い，高耐久で血液ダメージの少ない，ディスポーザブル血液ポンプを実現したので報告する．

DOI： 10.11511/jacc.50.0.31.0

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

羽根車が磁気軸受により非接触支持される遠心血液ポンプの体内埋め込みを目指し， 血液・臓器接触面に生体用チタン合金などの適用を検討している．羽根車と磁気浮上 用の渦電流変位計の間に位置するチタン隔壁は，変位計出力のゲイン低下や位相遅れ の問題を引き起こす可能性がある．本報告では，隔壁と羽根車内の変位測定用ターゲットの材質と厚みを変更した場合の，既存の渦電流変位計の静・動的な測定特性を実験的に評価している．

DOI： 10.11522/pscjspe.2006A.0.869.0

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記述言語：日本語   出版者・発行元：公益社団法人 精密工学会  

心臓手術中および術後の血液循環のため,血液に接触する部分のみ使い捨てできる遠心型の血液ポンプが利用されているが,インペラを支持するための接触式軸受の耐久性が低く,長時間の使用が困難である.このため,本研究では,使い捨て部分が低コストで製作できる磁気浮上血液ポンプを試作したので報告する.

DOI： 10.11522/pscjspe.2006S.0.867.0

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記述言語：日本語   出版者・発行元：The Society of Life Support Engineering  

Control of Hemolysis and Thrombosis in MagLev Centrifugal Rotary Blood Pumps 〇高谷節雄、大内克洋、星 英 男、渡邉宣夫、木戸和幸 、迫 田大輔 、傍 島秀雄、 中山歩美 、進士忠彦*、 朝 間淳 一*、 原 力*、 土方 亘*、 下河辺明* 東京医科歯科大学生体材料工学研究所生体 システム分野 *東 京工業大学精密工学研究所集積マ シン研究分野 Setsuo Takatani,Katsuhiro Ohuchi,Hideo Hoshi,Nobuo Watanabe ,Kazuyuki Kido,D aisuke Sakota,Hideo Sobajima,Ayumi Nakayama ,Tadahiko Shinshi,Junichi Asama,Wataru Hijikata,Akira Shimokohbe, Department of Artificial Organs ,Institute of Biomaterials and Bioengineering,Tokyo Medical and Dental University ,and *Department of Integrated Machine R esearch,Institute of Precision Control Engineering,Tokyo Institute of Technology

DOI： 10.5136/lifesupport.18.Supplement_40

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出版者・発行元：Springer Science and Business Media LLC  

DOI： 10.1007/bf02806937

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出版者・発行元：Wiley  

<jats:title>Abstract</jats:title><jats:p>A dry developable negative working resist composition comprised of poly(methyl isopropenyl ketone) (PMIPK) and 4‐methyl‐2,6‐di(4′‐azido‐benzylidene) cyclohexanone‐1 was examined. The main photochemical product formed in the resist pattern was found to be a secondary amine which crosslinks PMIPK. Post‐annealing forms a hydrogen‐bonded product which shows a powerful electronic excitation energy quenching effect. The quencher is more powerful than the aromatic compound arising from the azide by post‐annealing only. The residual resist thickness of the negative pattern is about 80 percent of the initial thickness of the coating in spite of all the azide compound remaining in the resist coating. The obtained dry developed resist pattern has a high dry etch resistance. Etchings of Si and SiO<jats:sub>2</jats:sub> were performed by plasma and reactive ion etching, respectively.</jats:p>

DOI： 10.1002/pen.760231804

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

垂直管の外面で凝縮熱伝達を促進するのに有効な微小な長手方向フィンについて,フィン内部の伝達導を考慮に入れて,フィン形状と伝熱性能との関係を理論的に調べた.その結果,凝縮液排除円板を一定間隔で取付け,平たんなみぞ底と放物断面形状のフィンをもつ垂直管が滴状凝縮と同等に高い熱伝達率を示すことがわかった.各種材質に応じたフィンピッチ及び円盤設置間隔の最適値を定める手法を確立した.

DOI： 10.1299/kikaib.48.527

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出版者・発行元：ASME International  

<jats:p>The purpose of this paper is to find an optimum surface geometry of vertical condenser tubes where condensation takes place on the outer surfaces. The guiding principle on optimum condensation performance is to make the thickness of condensate liquid on the surfaces as thin as possible. A vertical tube with longitudinally parallel tiny fins is preferable because condensate is made thinner over the widest possible region. According to an analysis, there are four controlling factors for the optimum fin; sharp leading edge, gradually changing curvature of fin surface from tip to the root, wide groove between fins to collect condensate and horizontal discs attached to the tube to remove condensate. The analytical result is checked by experiments using R-113. The optimum fin shape, fin pitch and spacing of discs are found by numerical calculations for R-113 and water.</jats:p>

DOI： 10.1115/1.3244439

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出版者・発行元：公益社団法人 応用物理学会  

DOI： 10.11470/oubutsu1932.50.145

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出版者・発行元：Elsevier BV  

Abstract This study reveals that, on a finned surface, there exists a region of high heat transfer coefficients in the trough between the crests of fins. A theoretical analysis had predicted a local thinness of the condensate film produced by the capillary action in the trough. This is confirmed by optical measurements of the film thickness in a flow of ethyl alcohol along the model vertical walls. The results of this experiment agree well with the theoretical prediction. Taking these effects into account, the performance of a vertical finned surface is computed using condensation of R-113 and water.

DOI： 10.1016/0017-9310(80)90151-9

CiNii Research

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出版者・発行元：Begellhouse  

DOI： 10.1615/ihtc6.170

CiNii Research

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

記事分類: 工業熱学・工業動力

DOI： 10.1299/kikai1938.44.2041

DOI： 10.1299/jsmemag.81.714_488_9

CiNii Books

CiNii Research

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I1948817

開催年月日： 2025年

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開催年月日： 2024年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年9月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年9月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年7月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年7月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2024年7月

記述言語：英語   会議種別：口頭発表（一般）  

Plasma skimming in spiral groove bearings (SGBs) has the potential to reduce hemolysis by guiding the red blood cells to escape from the narrow ridge gap with high shear stress force, to the larger groove gap. In our previous study, we designed an optimal SGB-PS that aims to improve plasma skimming inside the bearing gaps and verified its effectiveness under whole blood conditions up to 40% hematocrit level. This study extends our work by evaluating the load-carrying capacity of the optimized SGB design. We first analyzed the load-carrying capacity numerically by calculating the hydrodynamic force based on the Reynolds equation. Then we designed and manufactured an experimental device to measure the generated hydrodynamic force under comparable conditions. Our results indicate that the hydrodynamic force generated by the SGB-PS meets the requirements for our hydrodynamically levitated rotary blood pump and aligns well with our numerical analysis. This research contributes to improving the performance of the SGB for hemolysis resistance in hydrodynamically levitated rotary blood pumps.

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2024年

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開催年月日： 2024年

記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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開催年月日： 2024年

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2023年

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開催年月日： 2023年

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開催年月日： 2023年

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出願人：株式会社豊田中央研究所, 株式会社豊田自動織機, トヨタ自動車株式会社, アイシン精機株式会社

出願番号：特願2014-066650  出願日：2014年3月

公開番号：特開2015-192495  公開日：2015年11月

特許番号/登録番号：特許第5901678号  発行日：2016年3月

J-GLOBAL

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出願人：株式会社豊田中央研究所, 株式会社豊田自動織機, トヨタ自動車株式会社, アイシン精機株式会社

出願番号：特願2014-066650  出願日：2014年3月

公開番号：特開2015-192495  公開日：2015年11月

J-GLOBAL

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出願人：株式会社豊田自動織機, 株式会社豊田中央研究所

出願番号：特願2014-062994  出願日：2014年3月

公開番号：特開2015-182703  公開日：2015年10月

J-GLOBAL

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出願人：株式会社豊田中央研究所

出願番号：特願2013-233127  出願日：2013年11月

公開番号：特開2015-093542  公開日：2015年5月

J-GLOBAL

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出願人：株式会社豊田中央研究所

出願番号：特願2013-233127  出願日：2013年11月