Organization
School of Engineering Associate Professor
Title
Associate Professor
External link
YAMAMOTO TAKATOKI
News & Topics
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ウイルス監視ネットワークの構築による安全・安心社会の実現に向けて
2016/08/16
Languages： Japanese
東京工業大学 工学院の山本貴富喜（たかとき）准教授らは、病原性ウイルスのセンサーにつながるデバイス構造を開発している。ナノ（10億分の1）メートル（nm）幅の流路を設け、流路を通るウイルスを電気的に検出する仕組み。この仕組みにより、ウイルスの大きさ・形状によって異なるインピーダンス（電気抵抗）スペクトルが得られることを確かめた。この結果はウイルスの構造や成分などからウイルスを識別できる可能性を示唆しており、既知・未知を問わない網羅的なウイルスセンシング法が実現できると期待される。
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2016/08/16
Languages： English
Our living sphere is exposed to a wide range of pathogenic viruses?some known and others of novel origin.Currently, there is no method to continuously monitor the environment for viruses in general, and needless to say, a procedure for the rapid and sensitive identification of a wide variety of viruses for infectious diseases. Traditional approaches based on PCR and immunoassay only enable the detection of known viruses.Now, Ryuji Hatsuki and colleagues at have developed a simple sensing methodology that can potentially detect any virus between the spacing of two electrodes with an intervening several hundreds nanometer-sized gap by measurement of electrical properties of viruses known as impedance spectroscopy.The sensing device was fabricated on a quartz substrate patterned with two measurement electrodes of thin film of gold (250 nm thick) deposited on titanium (1 nm thick); a polydimethylsiloxane (PDMS) sheet forming the measurement chamber wall; and a glass plate as the chamber lid.The researchers discovered that the impedance of three kinds of virus solutions?differing in shape and size?responded differently depending both on the kind of virus and its concentration.Although further studies are required, the proposed method may achieve a sensitivity comparable to that of more traditional, but less versatile continuous virus detection methods, to monitor a wide range of environments for untroubled living conditions.
Research Interests
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マイクロ流体デバイス
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人工細胞
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1分子観察
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1分子操作
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ナノバイオ
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ナノデバイス
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マイクロデバイス
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cell culture
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regenerative medicine
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nano-interface
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細胞培養
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再生医療
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ナノ界面
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極限デバイス
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極限環境
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電気力学
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ナノ流体デバイス
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extreme device
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extreme environment
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nanofluidic device
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microfluidic device
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single-molecule analysis
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single-molecule manipulation
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nanobio
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nanodevice
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microdevice
Research Areas
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Nanotechnology/Materials / Nanomaterials
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Nanotechnology/Materials / Nano/micro-systems
Committee Memberships
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電気学会 インテリジェントバイオチップ技術調査専門調査委員
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電気学会 半導体生体インターフェイス技術調査専門委員会
Papers
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Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel
Katsuo Mogi, Kei Hayashida, Takatoki Yamamoto
ANALYTICAL SCIENCES 34 ( 8 ) 875 - 880 2018.8
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Damage-less handling of exosomes using an ion-depletion zone in a microchannel
Katsuo Mogi, Kei Hayashida, Takatoki Yamamoto
Analytical Sciences 34 ( 8 ) 875 - 880 2018
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Solid state direct bonding of polymers by vacuum ultraviolet light below 160 nm Reviewed
Yuki Hashimoto, Takatoki Yamamoto
Applied Surface Science 419 319 - 327 2017.10
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Development of Virus Concentration Device by Controlling Ion Depletion Zone for Ultrasensitive Virus Sensing Reviewed
Katsuo Mogi, Kei Hayashida, Ayae Honda, Takatoki Yamamoto
Electronics and Communications in Japan 100 ( 9 ) 56 - 63 2017.9
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Editorial: Perspectives for the next generation of virus research: Spearheading the use of innovative technologies and methodologies Reviewed
Takatoki Yamamoto, Ayae Honda, Toshinori Sato, Akihide Ryo
Frontiers in Microbiology 8 ( MAY ) 2017.5
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Vacuum ultraviolet light assisted bonding and nanoscale pattern transfer method for polydimethylsiloxane Reviewed
Yuki Hashimoto, Katsuo Mogi, Takatoki Yamamoto
MICROELECTRONIC ENGINEERING 176 116 - 120 2017.5
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Initial evaluation of the continuous sampling method using liquid-gate realized by porous membrane and hydrophilic/hydrophobic interface Reviewed
Kenshiro Sakata, Yang Lu, Katsuo Mogi, Takatoki Yamamoto
IEEJ Transactions on Sensors and Micromachines 137 ( 6 ) 169 - 173 2017
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Release agent-free low-cost double transfer nanoimprint lithography for moth-eye structure Reviewed
Y. Hashimoto, K. Mogi, T. Yamamoto
16th International Conference on Nanotechnology - IEEE NANO 2016 318 - 320 2016.11
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Sampling micro-nano size aerosol by droplet formation and using liquid-based gating mechanism Reviewed
K. Sakata, T. Yamamoto
16th International Conference on Nanotechnology - IEEE NANO 2016 288 - 290 2016.11
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A novel fabrication technique for liquid-tight microchannels by combination of a paraffin polymer and a photo-curable silicone elastomer Reviewed
Katsuo Mogi, Kenshiro Sakata, Yuki Hashimoto, Takatoki Yamamoto
Materials 9 ( 8 ) 1 - 8 2016.7
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Fabrication method for moth-eye structure made of glass using vacuum ultraviolet light vitrification of silicone Reviewed
Yuki Hashimoto, Katsuo Mogi, Takatoki Yamamoto
IEEJ Transactions on Sensors and Micromachines 136 ( 11 ) 488 - 492 2016
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Development of virus concentration device by controlling ion depletion zone for ultra-sensitive virus sensing Reviewed
Katsuo Mogi, Kei Hayashida, Ayae Honda, Takatoki Yamamoto
IEEJ Transactions on Sensors and Micromachines 136 ( 9 ) 363 - 369 2016
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Trapping and isolation of single prokaryotic cells in a micro-chamber array using dielectrophoresis Reviewed
K. Mogi, C. Shirataki, K. Kihara, H. Kuwahara, Y. Hongoh, T. Yamamoto
RSC Advances 6 ( 114 ) 113000 - 113006 2016
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Study of Metal Etching Using Ozone Water Reviewed
Ryuji Hatsuki, Takatoki Yamamoto
Electrical Engineering in Japan (English translation of Denki Gakkai Ronbunshi) 193 ( 1 ) 65 - 72 2015.10
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Single-molecule measurement and its application by electric impedance spectroscopy using nanochannel Reviewed
Takatoki Yamamoto
Bunseki Kagaku 64 ( 6 ) 431 - 440 2015.7
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Nanoscale three-dimensional optical visualization method for a deformation of elastomer printing plate to realize soft nano-printing technology Reviewed
Yuki Hashimoto, Katsuo Mogi, Takatoki Yamamoto
Surface and Interface Analysis 47 ( 6 ) 723 - 727 2015.6
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Nanometer-level high-accuracy molding using a photo-curable silicone elastomer by suppressing thermal shrinkage Reviewed
Katsuo Mogi, Yuki Hashimoto, Takeshi Tsukahara, Motoki Terano, Masahiko Yoshino, Takatoki Yamamoto
RSC Advances 5 ( 14 ) 10172 - 10177 2015
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Three-dimensional visualizing method at nanoscale resolution for printing behavior Reviewed
Yuki Hashimoto, Katsuo Mogi, Takatoki Yamamoto
IEEE-NANO 2015 - 15th International Conference on Nanotechnology 506 - 509 2015
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Conformation dependent non-linear impedance response of DNA in nanofluidic device Reviewed
Porpin Pungetmongkol, Katsuo Mogi, Takatoki Yamamoto
IEEE-NANO 2015 - 15th International Conference on Nanotechnology 1163 - 1166 2015
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Fabrication method of moth-eye using UV-curable polydimethylsiloxane with vitrification by vacuum ultraviolet light Reviewed
Yuki Hashimoto, Katsuo Mogi, Takatoki Yamamoto
IEEE-NANO 2015 - 15th International Conference on Nanotechnology 128 - 131 2015
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Nano-pattern molding technique using photocurable silicone elastomer Reviewed
Katsuo Mogi, Yuki Hashimoto, Takatoki Yamamoto, Takehiko Tsukahara
IEEE-NANO 2015 - 15th International Conference on Nanotechnology 1000 - 1003 2015
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Nonlinear electrical impedance spectroscopy of viruses using very high electric fields created by nanogap electrodes Reviewed
Ryuji Hatsuki, Ayae Honda, Masayuki Kajitani, Takatoki Yamamoto
Frontiers in Microbiology 6 2015
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Direct Evaluation of the Electrokinetic Properties of Electrolytes in a Nanochannel using Electrical Impedance Spectroscopy Reviewed
Porpin Pungetmongkol, Katsuo Mogi, Ryuji Hatsuki, Takatoki Yamamoto
ISRAEL JOURNAL OF CHEMISTRY 54 ( 11-12 ) 1607 - 1614 2014.11
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Rapid fabrication technique of nano/microfluidic device with high mechanical stability utilizing two-step soft lithography Reviewed
Katsuo Mogi, Yasuhiko Sugii, Takatoki Yamamoto, Teruo Fujii
SENSORS AND ACTUATORS B-CHEMICAL 201 407 - 412 2014.10
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Direct measurement of electric double layer in a nanochannel by electrical impedance spectroscopy Reviewed
Ryuji Hatsuki, Fuchigami Yujiro, Takatoki Yamamoto
Microfluidics and Nanofluidics 14 ( 6 ) 983 - 988 2013.6
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Solid-state bonding of silicone elastomer to glass by vacuum oxygen plasma, atmospheric plasma, and vacuum ultraviolet light treatment Reviewed
Takatoki Yamamoto
Surface and Interface Analysis 45 ( 4 ) 817 - 822 2013.4
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Fabrication of gold nanodot array on plastic films for bio-sensing applications Reviewed
Truong Duc Phuc, Masahiko Yoshino, Akinori Yamanaka, Takatoki Yamamoto
Procedia CIRP 5 47 - 52 2013
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Electrical evaluation of hydrated diameter dependent thickness of electric double layer in nanochannel Reviewed
P. Pungetmongkol, R. Hatsuki, T. Yamamoto
2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 1123 - 1126 2013
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機械屋のための分析装置ガイドブック（日本塑性加工学会編） Reviewed
吉野雅彦, 大竹尚登, 山本貴富喜, 山中晃徳, 中村吉男, 安田公一, 齊藤卓志, 源関聡, 津島将司, 黒川悠, 井上裕嗣, 山?敬久, 野崎智洋, 鈴木俊明, 梅原徳次, 近藤行人, 松村隆, 楊明, 月山陽介, 益満秀治, 赤上陽一, 久住孝幸, 上坂裕之, 野老山貴行, 品川一成, 新保實, 平山朋子, 早川邦夫, 坂井田喜久, 鈴木清一, 柏谷智
Vol. 2012.8
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Nanoscale etching and flattening of metals with ozone water Reviewed
Ryuji Hatsuki, Takatoki Yamamoto
Nano Letters 12 ( 6 ) 3158 - 3161 2012.6
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Single molecular level analysis and processing in nanochannels Reviewed
Takatoki Yamamoto
Frontiers in Bioscience - Scholar 4 ( 4 ) 1461 - 1474 2012.6
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Application of cell-free expression of GFP for evaluation of microsystems Reviewed
Takahiko Nojima, Shohei Kaneda, Hiroshi Kimura, Takatoki Yamamoto, Teruo Fujii
Frontiers in Bioscience 17 ( 1 ) 1931 - 1939 2012.1
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Modification of the glass surface property in PDMS-glass hybrid microfluidic devices Reviewed
Shohei Kaneda, Koichi Ono, Tatsuhiro Fukuba, Takahiko Nojima, Takatoki Yamamoto, Teruo Fujii
Analytical Sciences 28 ( 1 ) 39 - 44 2012.1
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Study of metal etching using ozone water Reviewed
Ryuji Hatsuki, Takatoki Yamamoto
IEEJ Transactions on Sensors and Micromachines 132 ( 11 ) 413 - 419 2012
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Electroactive Microwell Arrays for Highly Efficient Single-Cell Trapping and Analysis Reviewed
Soo Hyeon Kim, Takatoki Yamamoto, Dominique Fourmy, Teruo Fujii
SMALL 7 ( 22 ) 3239 - 3247 2011.11
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Study on 172-nm vacuum ultraviolet light surface modifications of polydimethylsiloxane for micro/nanofluidic applications Reviewed
Takatoki Yamamoto
Surface and Interface Analysis 43 ( 9 ) 1271 - 1276 2011.9
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Shohei Kaneda, Koichi Ono, Tatsuhiro Fukuba, Takahiko Nojima, Takatoki Yamamoto, Teruo Fujii
International Journal of Molecular Sciences 12 ( 7 ) 4271 - 4281 2011.7
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An electroactive microwell array for trapping and lysing single-bacterial cells Reviewed
Soo Hyeon Kim, Takatoki Yamamoto, Dominique Fourmy, Teruo Fujii
BIOMICROFLUIDICS 5 ( 2 ) 24114 2011.6
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A microfluidic in situ analyzer for ATP quantification in ocean environments Reviewed
Tatsuhiro Fukuba, Yusuke Aoki, Noriyuki Fukuzawa, Takatoki Yamamoto, Masanori Kyo, Teruo Fujii
LAB ON A CHIP 11 ( 20 ) 3508 - 3515 2011
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Direct bonding between silicone and glass by atmospheric-pressure surface modification Reviewed
Wataru Okada, Takatoki Yamamoto
IEEJ Transactions on Sensors and Micromachines 131 ( 4 ) 4 - 164 2011
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Integrated in situ genetic analyzer for microbiology in extreme environments Reviewed
Tatsuhiro Fukuba, Akimitsu Miyaji, Takuji Okamoto, Takatoki Yamamoto, Shohei Kaneda, Teruo Fujii
RSC ADVANCES 1 ( 8 ) 1567 - 1573 2011
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On-chip Glucose Sensor for Online Measurement of Cell Activities
木村啓志, 庄野裕基, PEREIRA-RODRIGUES Nazare, 山本貴富喜, 酒井康行, 藤井輝夫
電気学会論文誌 E 130 ( 10 ) 476-483 (J-STAGE) - 482 2010.12
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Shohei Kaneda, Koichi Ono, Tatsuhiro Fukuba, Takahiko Nojima, Takatoki Yamamoto, Teruo Fujii
Electrophoresis 31 ( 22 ) 3719 - 3726 2010.11
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Microfluidic Device with Integrated Glucose Sensor for Cell-based Assay in Toxicology Reviewed
H. Kimura, H. Takeyama, K. Komori, T. Yamamoto, Y. Sakai, T. Fujii
J. Robotics Mech. 22 594 - 600 2010
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An automated embryo culture system using dynamic microarray
H. Kimura, H. Nakamura, T. Kurakazu, T. Yamamoto, S. Takeuchi, Y. Sakai, T. Fujii
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 3 1544 - 1546 2010
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Integration of glucose sensors into a microfluidic device for measurement of cell's activity
Yuuki Shono, Nazare Pereira Rodorigues, Hiroshi Kimura, Takatoki Yamamoto, Yasuyuki Sakai, Teruo Fujii
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1958 - 1960 2009
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On-chip embryo manipulation using dynamic microarray system
Hiroshi Kimura, Hiroko Nakamura, Kosuke Iwai, Takatoki Yamamoto, Shoji Takeuchi, Yasuyuki Sakai, Teruo Fujii
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1874 - 1876 2009
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再生医療・動物実験代替への応用を指向した細胞培養の先端技術 化学物質の体内動態を再現する複合細胞培養系の開発と利用
西川昌輝, 中山秀謹, 木村啓志, 山本貴富喜, 藤井輝夫, 酒井康行
Bio Ind 25 ( 1 ) 17 - 25 2008.1
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Development of "IISA-ATP" system for in situ microbial activity assessment in deep-sea environment Reviewed
Yusuke Aoki, Tatsuhiro Fukuba, Takatoki Yamamoto, Teruo Fujii
OCEANS 2008 - MTS/IEEE KOBE TECHNO-OCEAN, VOLS 1-3 548 - 551 2008
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A chip-based in vitro model for cytotoxicity test using Caco-2 and Hep G2
Hiroshi Kimura, Takatoki Yamamoto, Yasuyuki Sakai, Teruo Fujii
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference 21 - 23 2008
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A droplet on demand microfluidic device for detecting DNA single base substitution using PNA probe
Shohei Kaneda, Takahiko Nojima, Takatoki Yamamoto, Teruo Fujii
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference 176 - 178 2008
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Size-based particle sorting by caliper walls in a wide microfluidic channel
Katsuo Mogi, Takatoki Yamamoto, Haruyuki Kinoshita, Teruo Fujii
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference 820 - 822 2008
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EVAPORATIVE PUMPING OF LIQUID IN NANOCHANNEL FOR ELECTRICAL MEASUREMENT OF A SINGLE BIOMOLECULE IN NANOFLUIDIC FORMAT Reviewed
Erwan Lennon, Takatoki Yamamoto, Sang Wook Lee, Teruo Fujii
2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3 566 - 569 2007
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An integrated microfluidic system for long-term culture and continuous monitoring of intestinal cells
H. Kimura, T. Yamamoto, Y. Sakai, T. Fujii
Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 182 - 184 2007
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Controlling the expression ratio of two proteins by inserting a terminator between the two genes
Takahiko Nojima, Angela C. Lin, Takatoki Yamamoto, Isao Endo, Teruo Fujii
Nucleic Acids Chemistry Symposium Series 50 ( 50 ) 329 - 330 2006.11
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Development and analysis of multi-laminar chemical delivery platform toward single molecular application Reviewed
SangWook Lee, Takatoki Yamamoto, Shigeki Segawa, Kimura Hiroshi, Hiroyuki Noji, Teruo Fujii
Proceedings of the 4th International Conference on Nanochannels, Microchannnels, and Minichannels, Pts A and B 817 - 822 2006
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Relationship between hydrophobic beads attachment and fluid flow in PDMS microchannel Reviewed
T. Okamoto, T. Yamamoto, A. Takamatsu, N. Kaneko, T. Fujii
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology 119 - 122 2006
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Microfluidic devices for ultra wide band electromagnetic spectroscopy of single cell Reviewed
T. Akalin, S. Arscott, B. Bocquet, N. E. Bourzgui, V. Mille, V. Senez, A. Treizebré, T. Fujii, E. Lennon, Y. Sakai, T. Yamamoto
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology 252 - 255 2006
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Two-compartments microbioreactor with integrated magnetic stirrer pump for measurement of transmembrane transport of Caco-2 CELLS Reviewed
H. Kimura, H. Sakai, S. Ostrovidov, T. Yamamoto, Y. Sakai, T. Fujii
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology 112 - 115 2006
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Development of micro perfusion cell culture device to create in vivo-like environments for long-period and real-time monitoring of cells activities Reviewed
Hiroshi Kimura, Hitomi Sakai, Takatoki Yamamoto, Yasuyuki Sakai, Teruo Fujii
2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE 162 - + 2006
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Highly selective and sensitive DNA measurement by micro electrical impedance spectroscopy Reviewed
Sang Wook Lee, Takatoki Yamamoto, Teruo Fujii
Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05 2 1314 - 1317 2005
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Development of miniaturized in situ analysis devices for biological and chemical oceanography Reviewed
T. Fukuba, A. Imhof, M. Matsunaga, N. Takagi, T. Yamamoto, K. Okamura, T. Naganuma, T. Fujii
2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology 2005 56 - 59 2005
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Integration of three-dimensional microelectrodes in microfluidic biochip for electric field based processing of biological species: Application to electrical impedance spectroscopy Reviewed
E. Lennon, V. Senez, T. Yamamoto, H. Fujita, T. Fujii
Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05 2 1724 - 1727 2005
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Characterization of single red blood cell using twin microcantilever type sensor array Reviewed
YH Cho, N Takama, T Yamamoto, T Fujii, BJ Kim
Transducers '05, Digest of Technical Papers, Vols 1 and 2 1692 - 1695 2005
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MEMS-based biochip for the characterization of single red blood cell Reviewed
YH Cho, N Takama, T Yamamoto, T Fujii, BJ Kim
2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology 60 - 63 2005
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マイクロ流路内における疎水性粒子の付着パターン解析
岡本拓士, 金子直嗣, 高松敦子, 山本貴富喜, 藤井輝夫
可視化情報(第33回可視化情報シンポジウム講演論文集) 25 ( suppl. no.1 ) 293 - 294 2005
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SENEZ Vincent, YAMAMOTO Takatoki, POUSSARD Benoit, FUKUBA Tatsuhiro, CAPRON Jean-Marc, FUJII Teruo
Monthly journal of the Institute of Industrial Science, University of Tokyo 56 ( 1 ) 97 - 100 2004.1
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Control of oscillation patterns in a symmetric coupled biological oscillator system
Atsuko Takamatsu, Reiko Tanaka, Takatoki Yamamoto, Teruo Fujii
AIP Conference Proceedings 676 230 - 235 2003.8
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PDMS-glass hybrid microreactor array with embedded temperature control device. Application to cell-free protein synthesis Reviewed
Takatoki Yamamoto, Takahiko Nojima, Teruo Fujii
Lab on a Chip 2 ( 4 ) 197 - 202 2002.11
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3O1130 Control of Spatio-temporal Symmetric Oscillations in a Coupled Oscillator System of the Plasmodium of Physaurum, polycephalum
Takamatsu A., Tanaka R., Yamamoto T., Fujii T.
Seibutsu Butsuri 42 ( 2 ) S202 2002
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Cell-free protein synthesis in PDMS-based parallel microreactors Reviewed
Takatoki Yamamoto, Takahiko Nojima, Teruo Fujii
Micro Total Analysis Systems 2001 (Proceedings of the microTAS 2001 Symposium, held in Monterey, CA, USA, 21-25 October 2001) 69 - 71 2001.10
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Development of hybrid microreactor for protein synthesis Reviewed
Takatoki Yamamoto, Teruo Fujii, Takahiko Nojima, Jong Wook Hong, Isao Endo
Transactions of the Institute of Electrical Engineers of Japan 121E ( 4 ) 163 - 168 2001.4
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Cell-free protein synthesis in PDMS-glass hybrid microreactor Reviewed
Yamamoto Takatoki, Fujii Teruo, Nojima Takahiko, Hong Jong Wook, Endo Isao
Proceedings of SPIE - The International Society for Optical Engineering 4177 72 - 79 2000
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PDMS (polydimethylsiloxane)-glass hybrid microchip for gene amplification Reviewed
JW Hong, T Fujii, M Seki, T Yamamoto, Endo, I
1ST ANNUAL INTERNATIONAL IEEE-EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGIES IN MEDICINE & BIOLOGY, PROCEEDINGS 407 - 410 2000
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Molecular surgery of DNA based on electrostatic micromanipulation Reviewed
T Yamamoto, O Kurosawa, H Kabata, N Shimamoto, M Washizu
CONFERENCE RECORD OF THE 1998 IEEE INDUSTRY APPLICATIONS CONFERENCE, VOLS 1-3 1933 - 1940 1998
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Molecular surgery of DNA Reviewed
Takatoki Yamamoto, Masao Washizu, Osamu Kurosawa, Nobuo Shimamoto
Proceedings of SPIE - The International Society for Optical Engineering 3202 228 - 235 1998
MISC
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trapping and breaking of single prokaryotic cells using electrodynamic operation
SUZUKI Sho, YAMAMOTO Takatoki, MOGI Katsuo
The Proceedings of the Symposium on Micro-Nano Science and Technology 2017 ( 0 ) PN - 100 2017
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Evaluation technique for ion-depletion zone effect on exosome by using an atomic-force microscopy
MOGI Katsuo, HAYASHIDA Kei, YAMAMOTO Takatoki
The Proceedings of the Symposium on Micro-Nano Science and Technology 2017 ( 0 ) PN - 32 2017
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Quantification of virus particles using nanopore-based resistive-pulse sensing techniques
Lu Yang, Takatoki Yamamoto
Frontiers in Microbiology 7 2016.9
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Nanometer-level high-accuracy molding using a photo-curable silicone elastomer by suppressing thermal shrinkage (vol 5, pg 10172, 2015
Katsuo Mogi, Yuki Hashimoto, Takehiko Tsukahara, Motoki Terano, Masahiko Yoshino, Takatoki Yamamoto
RSC ADVANCES 5 ( 17 ) 13166 - 13166 2015
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29pm2-A-3 Isolation of microorganisms by dielectrophoretic-trapping with micro/nanogap electrodes
MOGI Katsuo, SHIRATAKI Chikako, HONGO Yuichi, YAMAMOTO Takatoki
The Proceedings of the Symposium on Micro-Nano Science and Technology 2015 ( 0 ) _29pm2 - A-3-_29pm2-A-3 2015
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29pm2-A-4 Separation and condensation of bio-nanoparticles using ion depletion effect
HAYASHIDA Kei, MOGI Katsuo, Honda Ayae, YAMAMOTO Takatoki
The Proceedings of the Symposium on Micro-Nano Science and Technology 2015 ( 0 ) _29pm2 - A-4-_29pm2-A-4 2015
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22pm1-F2 Development of nano/micro fabrication method with photosensitive silicone
Mogi Katsuo, Hashimoto Yuki, Tsukahara Takehiko, Yamamoto Takatoki
The Proceedings of the Symposium on Micro-Nano Science and Technology 2014 ( 0 ) _22pm1 - F2--_22pm1-F2- 2014
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20am2-E3 Development of structural-color sensing device by biomimetic nano-structure
Ninomiya Ryo, Yamamoto Takatoki, Mogi Katsuo
The Proceedings of the Symposium on Micro-Nano Science and Technology 2014 ( 0 ) _20am2 - E3--_20am2-E3- 2014
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HAYASHIDA Kei, MOGI Katsuo, YAMAMOTO Takatoki
The Proceedings of the Symposium on Micro-Nano Science and Technology 2014 ( 0 ) _20pm1 - A5--_20pm1-A5- 2014
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茂木克雄, 杉井康彦, 山本貴富喜, 藤井輝夫
電気学会バイオ・マイクロシステム研究会資料 BMS-13 ( 24-34 ) 29 - 32 2013.8
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A visualization System for Time-course Analysis of Floating Microorganisms
茂木克雄, 杉井康彦, 山本貴富喜, 藤井輝夫, 松本洋一郎
可視化情報学会誌 33 ( Suppl.1 ) 379‐382 2013.7
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ソフトリソグラフィを用いた硬質マイクロ流体デバイスの高効率製作手法の開発
茂木克雄, 杉井康彦, 山本貴富喜, 藤井輝夫
センサ・マイクロマシンと応用システムシンポジウム(CD-ROM) 30th ROMBUNNO.6PM3-PSS-12 2013
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蛍光蛋白質の生体外発現を演算レポーターに用いるDNAロジックゲート
野島高彦, 山本貴富喜, 木村啓志, 藤井輝夫
日本化学会講演予稿集 92nd ( 3 ) 765 2012.3
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DNA増幅反応と生体外蛋白質合成を組み合わせた分子論理ゲートシステムの構築
野島高彦, 山本貴富喜, 木村啓志, 藤井輝夫
日本化学会講演予稿集 91st ( 3 ) 687 2011.3
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Nanofluidic single-molecule sorting of DNA: a new concept in separation and analysis of biomolecules towards ultimate level performance
Takatoki Yamamoto, Teruo Fujii
NANOTECHNOLOGY 21 ( 39 ) 395502 2010.10
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Biomolecular Nano-Flow-Sensor to Measure Near-Surface Flow
Sang-Wook Lee, Haruyuki Kinoshita, Hiroyuki Noji, Teruo Fujii, Takatoki Yamamoto
NANOSCALE RESEARCH LETTERS 5 ( 2 ) 296 - 301 2010.2
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マイクロ流体デバイスの細胞培養への応用
木村啓志, 山本貴富喜, 竹内昌治ね, 酒井康行, 藤井輝夫
バイオチップ実用化ハンドブック 557 - 563 2010
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On-Chip Single Embryo Coculture With Microporous-Membrane-Supported Endometrial Cells
Hiroshi Kimura, Hiroko Nakamura, Tomonori Akai, Takatoki Yamamoto, Hideshi Hattori, Yasuyuki Sakai, Teruo Fujii
IEEE TRANSACTIONS ON NANOBIOSCIENCE 8 ( 4 ) 318 - 324 2009.12
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Controlling the differentiation of mouse embryonic stem cells by laminar flow in microenvironment
Jiro Kawada, Hiroshi Kimura, Takatoki Yamamoto, Hidenori Akutsu, Yasuyuki Sakai, Teruo Fujii
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 108 S160 - S160 2009.11
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Design optimization and evaluation of a bioluminescence detection part on a microfluidic device for in situ ATP quantification
Yusuke Aoki, Tatsuhiro Fukuba, Takatoki Yamamoto, Terao Fujii
IEEJ Transactions on Sensors and Micromachines 129 ( 3 ) 73 - 76 2009
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体内毒性試験のためのオンチップin vitroモデルの構築
木村啓志, 山本貴富喜, 酒井康行, 藤井輝夫
化学とマイクロ・ナノシステム研究会誌 8 ( 1 ) 16 - 17 2009
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Development of on-chip coculture system for cytotoxicity test using Caco-2 and Hep G2
Hiroshi Kimura, Hidenari Nakayama, Takatoki Yamamoto, Yasuyuki Sakai, Teruo Fujii
IEEJ Transactions on Sensors and Micromachines 129 ( 8 ) 5 - 258 2009
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NISHIKAWA Masaki, KOJIMA Nobuhiko, YAMAMOTO Takatoki, NAKAJIMA Yoshihiro, OHMIYA Yoshihiro, FUJII Teruo, SAKAI Yasuyuki
Monthly journal of the Institute of Industrial Science, University of Tokyo 60 ( 2 ) 152 - 159 2009
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Study of automated embryo manipulation using dynamic microarray: Trapping, culture and collection
Hiroshi Kimura, Hiroko Nakamura, Kosuke Iwai, Takatoki Yamamoto, Shoji Takeuchi, Teruo Fujii, Yasuyuki Sakai
IEEJ Transactions on Sensors and Micromachines 129 ( 8 ) 4 - 251 2009
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野島高彦, 山本貴富喜, 木村啓志, 藤井輝夫
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 11th 290 2008.9
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オンデマンド型液滴ハンドリングデバイスを用いたPNAプローブ法によるDNAの一塩基置換検出
金田祥平, 野島高彦, 山本貴富喜, 藤井輝夫
化学とマイクロ・ナノシステム研究会講演要旨集 17th 54 2008.5
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DNA増幅と遺伝子発現にもとづくロジックゲート構築のこころみ
野島高彦, 山本貴富喜, 木村啓志, 藤井輝夫
化学とマイクロ・ナノシステム研究会講演要旨集 17th 98 2008.5
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Integrated 3-D silicon electrodes for electrochemical sensing in microfluidic environments: Application to single-cell characterization
V. Senez, E. Lennon, S. Ostrovidov, T. Yamamoto, H. Fujita, Y. Sakai, T. Fujii
IEEE SENSORS JOURNAL 8 ( 5-6 ) 548 - 557 2008.5
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Stable immobilization of rat hepatocytes as hemispheroids onto collagen-conjugated poly-dimethylsiloxane (PDMS) surfaces: Importance of direct oxygenation through PDMS for both formation and function
Masaki Nishikawa, Takatoki Yamamoto, Nobuhiko Kojima, Komori Kikuo, Teruo Fujii, Yasuyuki Sakai
BIOTECHNOLOGY AND BIOENGINEERING 99 ( 6 ) 1472 - 1481 2008.4
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Evaluation of cell-free protein synthesis using PDMS-based microreactor Arrays
Takatoki Yamamoto, Mami Hino, Rei Kakuhata, Takahiko Nojima, Yasuo Shinohara, Yoshinobu Baba, Teruo Fujii
ANALYTICAL SCIENCES 24 ( 2 ) 243 - 246 2008.2
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Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts
Masaki Nishikawaa, Nobuhiko Kojimaa, Kikuo Komoria, Takatoki Yamamoto, Teruo Fujii, Yasuyuki Sakai
JOURNAL OF BIOTECHNOLOGY 133 ( 2 ) 253 - 260 2008.1
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Polymerase chain reaction-based biochemical logic gate coupled with cell-free transcription-translation of green fluorescent protein as a report gate
Takahiko Nojima, Takatoki Yamamoto, Hiroshi Kimura, Teruo Fujii
CHEMICAL COMMUNICATIONS ( 32 ) 3771 - 3773 2008
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An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models
Hiroshi Kimura, Takatoki Yamamoto, Hitomi Sakai, Yasuyuki Sakai, Teruo Fujii
LAB ON A CHIP 8 ( 5 ) 741 - 746 2008
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Active immobilization of biomolecules on a hybrid three-dimensional nanoelectrode by dielectrophoresis for single-biomolecule study
Takatoki Yamamoto, Teruo Fujii
NANOTECHNOLOGY 18 ( 49 ) 495503 - 495509 2007.12
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Multi-functional Integration of Microfluidic Device for Highly-Sophisticated Cell Culture and Analysis
KIMURA Hiroshi, YAMAMOTO Takatoki, SAKAI Yasuyuki, FUJII Teruo
2007 ( 32 ) 13 - 17 2007.9
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Development of microfluidic chip as a platform for single-molecule observation : Chemical delivery in a microchannel using multi-laminar flow
YAMAMOTO Takatoki, LEE SangWook, FUJII Teruo, NOJI Hiroyuki
2007 ( 7 ) 13 - 18 2007.7
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三浦健, 小島伸彦, 陣偉雄, 鈴木宏明, 木村啓志, 山本貴富喜, 藤井輝夫, 竹内昌治, 酒井康行
化学工学会年会研究発表講演要旨集 72nd 383 2007.2
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高酸素透過性材料の表面改質によるラット初代肝細胞の高機能安定培養
西川昌輝, 小島伸彦, 山本貴富喜, 藤井輝夫, 酒井康行
化学工学会年会研究発表講演要旨集 72nd 387 2007.2
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飯田隆一, 山本創太, 小島伸彦, 山本貴富喜, 酒井康行, 大島まり
バイオエンジニアリング講演会講演論文集 19th 300 - 301 2007.1
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Microfluidic Perfusion Culture of Human Hepatocytes
H. Kimura, M. Nishikawa, T. Yamamoto, Y. Sakai, T. Fujii
Journal of Robotics and Mechatronics 9 550 - 556 2007
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流体の力学的作用による血管損傷の定量的検討~in vitro血管損傷評価システムの開発~
飯田隆一, 山本創太, 小島伸彦, 山本貴富喜, 酒井康行, 大島まり
日本機械学会バイオフロンティア講演会講演論文集 17th 53 - 54 2006.11
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野島高彦, LIN Angela C, 山本貴富喜, 遠藤勲, 藤井輝夫
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 9th 332 2006.9
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Chemical delivery microsystem for single-molecule analysis using multilaminar continuous flow
SW Lee, T Yamamoto, H Noji, T Fujii
ENZYME AND MICROBIAL TECHNOLOGY 39 ( 3 ) 519 - 525 2006.7
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Development of microfluidic device for electrical/physical characterization of single cell
YH Cho, T Yamamoto, Y Sakai, T Fujii, B Kim
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS 15 ( 2 ) 287 - 295 2006.4
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Top-Down’ Approaches for the Study of Single-Cells: Micro-Engineering and Electrical Phenotype
V. Senez, T. Akalin, S. Arscott, N.E. Bourzgui, B. Bocquet, T. Fujii, E. Lennon, T. Yamamoto
Advances in Science and Technology 53 97 - 106 2006
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Development of MEMS Device for Electrical and Physical Characterization of Single Cell
CHO Younghak, TAKAMA Nobuyuki, YAMAMOTO Takatoki, FUJII Teruo, KIM Beomjoon
The Journal of the Institute of Electrical Engineers of Japan 126 ( 3 ) 89 - 94 2006
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YAMAMOTO Takatoki
J. Surf. Sci. Soc. Jpn. 27 ( 2 ) 102 - 107 2006
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PDMSマイクロ流路内における疎水性粒子付着と流れ場の関係
岡本拓士, 岡本拓士, 高松敦子, 金子直嗣, 山本貴富喜, 藤井輝夫
化学とマイクロ・ナノシステム研究会講演要旨集 13th 2006
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山本 貴富喜, 藤井 輝夫
ケミカルエンジニヤリング 50 ( 11 ) 880 - 887 2005.11
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Development of an in situ Gene Analysis Device for Extreme Environmental Microbiology
Fukuba Tatsuhiro, Yamamoto Takafuki, Naganuma Takeshi, Fujii Teruo
Journal of the Oceanographical Society of Japan 14 ( 2 ) 361 - 368 2005
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Microfabricated flow-through device for DNA amplification - towards in situ gene analysis
T Fukuba, T Yamamoto, T Naganuma, T Fujii
CHEMICAL ENGINEERING JOURNAL 101 ( 1-3 ) 151 - 156 2004.8
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Spontaneous switching of frequency-locking by periodic stimulus in oscillators of plasmodium of the true slime mold
A Takamatsu, T Yamamoto, T Fujii
BIOSYSTEMS 76 ( 1-3 ) 133 - 140 2004.8
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PDMS-glass hybrid microreactor array with embedded temperature control device. Application to cell-free protein synthesis
T Yamamoto, T Nojima, T Fujii
LAB ON A CHIP 2 ( 4 ) 197 - 202 2002
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Integration of gene amplification and capillary gel electrophoresis on a polydimethylsiloxane-glass hybrid microchip
JW Hong, T Fujii, M Seki, T Yamamoto, Endo, I
ELECTROPHORESIS 22 ( 2 ) 328 - 333 2001.1
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Development of Hybrid Microreactor for Protein Synthesis
Takatoki Yamamoto, Teruo Fujii, Takahiko Nojima, Jong Wook Hong, Isao Endo
IEEJ Transactions on Sensors and Micromachines 121 ( 4 ) 163 - 168 2001
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Parallel Cell-free Protein Synthesis on an Integrated Microchip
Yamamoto Takatoki, Nojima Takahiko, Fujii Teruo
Monthly journal of the Institute of Industrial Science, University of Tokyo 53-2, ( 2 ) 8 - 11 2001
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藤井輝夫, 山本貴富喜, 野島高彦, HONG J W, 遠藤勲
化学とマイクロシステム研究会講演要旨集 2nd 34 2000.9
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Molecular surgery of DNA based on electrostatic micromanipulation
T Yamamoto, O Kurosawa, H Kabata, N Shimamoto, M Washizu
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS 36 ( 4 ) 1010 - 1017 2000.7
Presentations
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マイクロ・ナノ流体デバイスのライフサイエンス応用
日本機械学会，実験流体力学－マイクロ流れ実験の基礎と応用－ 2010
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MEMS技術を応用した細胞機能測定
定量生物学の会 第一回年会 2009
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細胞機能アッセイへ向けたマイクロ流体デバイス
4大学ナノ・マイクロファブリケーションコンソーシアム 拠点形成シンポジウム 2009
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Study of Automated Embryo Manipulation using Dynamic Array: Trapping, Culture and Collection
International Conference on Microtechnologies in Medicine and Biology 2009
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STUDY OF AUTOMATED EMBRYO MANIPULATION USING DYNAMICMICROARRAY: TRAPPING, CULTURE AND COLLECTION
he 5th internationalConference on Microtechnologies in Medicine and Biology(MMB2009) 2009
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4大学ナノ・マイクロファブリケーションコンソーシアム 拠点形成シンポジウム
4大学ナノ・マイクロファブリケーションコンソーシアム 2009
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ON-CHIP EMBRYO MANIPULATION USING DYNAMIC MICROARRAY SYSTEM
The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009) 2009
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INTEGRATION OF GLUCOSE SENSORS INTO A MICROFLUIDIC DEVICE FOR MEASUREMENT OF CELL’S ACTIVITY
The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009) 2009
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Design using COMSOL for life science application of microfabrication technology
COMSOL Conference Tokyo 2009 2009
Works
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電気学会 半導体生体インターフェイス技術調査専門委員
2010.10 - 2012.9
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日本機械学会2011年度年次大会実行委員
2010.4 - 2011.9
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ＩＣＭＴ２０１０投稿論文校閲委員
2010.3 - 2010.11
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電気学会E部門誌論文委員
2009.4
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インテリジェントバイオチップ技術調査専門委員
2006.10 - 2008.10
Research Projects
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Clarification of various properties and establishment of theoretical bases in AC nanopore metrology.
Grant number：23K26112 2023.4 - 2026.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Grant amount：\19240000 （ Direct Cost: \14800000 、 Indirect Cost：\4440000 ）
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2022 - 2024
科学技術振興機構 産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) 産学共同(育成型)
山本 貴富喜
交流ナノポア法(ACナノポア法)は,ユニバーサルに様々な微生物を計測可能で,高速・高精度,小型で現場計測に適した技術である。本研究では微生物サイズの断面(数100nm〜数μm)で長さが数10μm以上のストロー型ナノポアの作製技術を確立し,AC測定の特徴を生かす広帯域でのインピーダンス測定能を生かした微生物センシングを実現する。さらに清掃現場での評価から、現場性能に磨きをかける。これらの開発によってACナノポア法の基盤技術を確立しつつ微生物同定能を高度化し、住環境における微生物センシングおよび業務清掃における衛生状態のオンデマンド計測サービスへの展開を図る。
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Single bacteria sensing using nonlinear electrical impedance response in high electric field created in nano-scaled space
Grant number：20H02160 2020.4 - 2023.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Yamamoto Takakatoki
Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）
Through the demonstration of the measurement of a single bacterial particle flowing in a microfluidic channel, we have demonstrated the electrical impedance measurement of a single bio-nanoparticle under a high electric field. Furthermore, we developed an analysis method to identify bacterial species from the measurement data using machine learning, and pioneered the realization of a "growing sensor," in which artificial intelligence grows in accordance with the amount of measurement and improves the classification performance of bacterial species. As a result, it was clarified that even if the size and material are the same, impedance characteristics can be obtained depending on the surface condition. By utilizing these characteristics and also using machine learning, we have demonstrated that bacteria of almost the same size can be classified with an accuracy of more than 95%.
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ナノ界面空間での電気二重層制御を利用した一分子電気インピーダンス計測法の創成
2008 - 2011
科学技術振興機構 戦略的な研究開発の推進 戦略的創造研究推進事業 さきがけ
山本 貴富喜
Authorship：Principal investigator
空間のサイズを小さくしていくと体積に対する表面積の割合が大きくなり、ナノメートル近くにもなると内部の物理が表面の状態に支配されるようになります。本研究では、分子1個の大きさに近いナノメートルサイズの流路に生ずるこうした極微小効果を利用して、生体分子を1分子ずつ流しながら、途中に組み込んだ電極を使って分子の動きを制御したり、1分子を測定する、1分子分析法の創成を目指します。