Updated on 2026/03/10

写真a

 
FUKUHARA GAKU
 
Organization
School of Science Visiting Professor
Title
Visiting Professor
External link

News & Topics

Degree

  • Doctor(Engineering) ( Osaka University )

Research Interests

  • Allosterism

  • Photochemistry

  • Amplification sensing

  • Preventive Medicine

  • Combination therapy

  • Soft materials

  • Chemosensors

  • Supramolecular chemistry

  • Acoustic medicine

  • Cancer treatment

Research Areas

  • Nanotechnology/Materials / Functional solid state chemistry

  • Life Science / Aquatic life science

Education

  • Osaka University   Graduate School, Division of Engineering   Department of Molecular Chemistry

    - 2004

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  • Osaka University

    - 2004

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    Country： Japan

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Research History

  • Kyushu University   Institute for Materials Chemistry and Engineering   Professor

    2025.4

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  • Tokyo Institute of Technology   Department of Chemistry   Associate Professor

    2017.4 - 2025.3

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  • Osaka University   Graduate School of Engineering Division of Applied Chemistry   Assistant Professor

    2008.4 - 2017.3

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  • Massachusetts Institute of Technology   Institute for Soldier Nanotechnologies   JSPS Research Fellow (PD)

    2007.4 - 2008.3

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  • Former Institution /Organization Osaka University, Graduate School of Engineering   Department of Molecular Chemistry   Student

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Professional Memberships

Papers

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MISC

  • Chirality Singal-amplification Sensing via a Sumanene-based Supramolecular Polymerization

    QI Ruipu, 水野裕彬, 燒山佑美, 櫻井英博, 福原学

    日本化学会春季年会講演予稿集(Web)   104th   2024

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  • Effect of micro-solution’s motion on acid-base equilibrium

    前田貴登, 稲川有徳, 福原学, 沼田宗典

    ホスト-ゲスト・超分子化学シンポジウム講演要旨集   21st (Web)   2024

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  • Steroid Sensing via a Sumanene-based Supramolecular Polymerization

    水野裕彬, 中澤廣宣, 宮川晃尚, 燒山佑美, 川内進, 櫻井英博, 福原学

    ホスト-ゲスト・超分子化学シンポジウム講演要旨集   20th   2023

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  • Signal-amplification Sensing via Sumanene-based Supramolecular Polymerization

    水野裕彬, 中澤廣宣, 宮川晃尚, 燒山佑美, 川内進, 櫻井英博, 福原学

    日本化学会春季年会講演予稿集(Web)   103rd   2023

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  • スマネンのスタックに基づくシグナル増幅センシング

    水野裕彬, 中澤廣宣, 宮川晃尚, 燒山佑美, 櫻井英博, 福原学

    分析化学討論会講演要旨集(Web)   82nd   2022

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  • Kinetic energy in a microfluid realizes an anisotropic reaction at the ends of a supramolecular nanofiber

    神崎千沙子, 稲川有徳, 福原学, 福原学, 岡田哲男, 成島哲也, 岡本裕巳, 沼田宗典

    日本化学会春季年会講演予稿集(Web)   101st   2021

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  • Kinetic supramolecular self-assemblies driven by proton gradient and investigation of their mechanisms

    神崎千沙子, 稲川有徳, 福原学, 福原学, 岡田哲男, 成島哲也, 岡本裕巳, 沼田宗典

    日本化学会春季年会講演予稿集(CD-ROM)   100th   2020

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  • Size dependent of emission behavior of tetraphenylethylene in freeze concentrated solution

    宮川晃尚, 福原学, 岡田哲男

    日本分光学会年次講演会(CD-ROM)   2020   2020

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  • 高圧下におけるテトラフェニルエチレンの分配挙動の評価

    宮川晃尚, 木下智和, YUE Zheng, 原田誠, 福原学, 岡田哲男

    分析化学討論会講演要旨集(Web)   80th   2020

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  • Spectroscopic characterization of cyano-naphthol aggregates in aqueous solution confined by ice

    武藤智也, 原田誠, 福原学, 岡田哲男

    日本分光学会年次講演会(CD-ROM)   2020   2020

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  • スマネンのスタックに基づく分子センシング

    水野裕彬, 中澤廣宣, 宮川晃尚, 原田誠, 岡田哲男, 植竹裕太, 燒山佑美, 櫻井英博, 福原学, 福原学

    分析化学討論会講演要旨集(Web)   80th   2020

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  • Induction of intermolecular interaction and control the structures of supramolecular through the fluidic energy in the microflow

    的場聖太, 稲川有徳, 福原学, 福原学, 岡田哲男, 成島哲也, 岡本裕巳, 沼田宗典

    日本化学会春季年会講演予稿集(CD-ROM)   100th   2020

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  • 凍結によるテトラフェニルエチレンの発光挙動

    宮川晃尚, 原田誠, 福原学, 岡田哲男

    日本分析化学会年会講演要旨集(Web)   68th   2019

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  • 定常的なエネルギー供給により実現する高活性超分子の創製とその速度論的安定化

    神崎千沙子, 稲川有徳, 福原学, 福原学, 岡田哲男, 沼田宗典

    ホスト-ゲスト・超分子化学シンポジウム講演要旨集   17th   2019

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  • 高圧溶媒抽出による分配係数の圧力変化の評価

    宮川晃尚, 福原学, 岡田哲男

    日本分析化学会年会講演要旨集(Web)   68th   2019

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  • 凍結不斉List-Barbas-Mannich反応における特異的エナンチオマー過剰率の起源

    飯島弘貴, 原田誠, 福原学, 岡田哲男

    日本化学会春季年会講演予稿集(CD-ROM)   99th   2019

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  • Polymer-based supramolecular sensing and application to chiral photochemistry

    Gaku Fukuhara

    POLYMER JOURNAL   47 ( 10 )   649 - 655   2015.10

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    Language：English   Publishing type：Book review, literature introduction, etc.  

    DOI： 10.1038/pj.2015.52

    Web of Science

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  • Dual Chiral, Dual Supramolecular Diastereodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate Tethered to Amylose Scaffold

    Gaku Fukuhara, Tomohiro Nakamura, Cheng Yang, Tadashi Mori, Yoshihisa Inoue

    ORGANIC LETTERS   12 ( 15 )   3510 - 3513   2010.8

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  • Diastereodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate Tethered to Cellulose Scaffold

    Gaku Fukuhara, Tomohiro Nakamura, Cheng Yang, Tadashi Mori, Yoshihisa Inoue

    JOURNAL OF ORGANIC CHEMISTRY   75 ( 12 )   4307 - 4310   2010.6

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  • Photochirogenesis in chiral ionic liquid: enantiodifferentiating [4+4] photocyclodimerization of 2-anthracenecarboxylic acid in (R)-1-methyl-3-(2,3-dihydroxypropyl)imidazolium bistriflimide

    Gaku Fukuhara, Cinzia Chiappe, Andrea Mele, Bernardo Melai, Fabio Bellina, Yoshihisa Inoue

    CHEMICAL COMMUNICATIONS   46 ( 20 )   3472 - 3474   2010

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  • Competitive Enantiodifferentiating Anti-Markovnikov Photoaddition of Water and Methanol to 1,1-Diphenylpropene Using A Sensitizing Cyclodextrin Host

    Gaku Fukuhara, Tadashi Mori, Yoshihisa Inoue

    JOURNAL OF ORGANIC CHEMISTRY   74 ( 17 )   6714 - 6727   2009.9

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    Language：English   Publishing type：Book review, literature introduction, etc.  

    DOI： 10.1021/jo9012628

    Web of Science

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  • Entropy-controlled supramolecular photochirogenesis: Enantiodifferentiating Z-E photoisomerization of cyclooctene included and sensitized by permethylated 6-O-modified beta-cyclodextrins International journal

    Gaku Fukuhara, Tadashi Mori, Takehiko Wada, Yoshihisa Inoue

    JOURNAL OF ORGANIC CHEMISTRY   71 ( 21 )   8233 - 8243   2006.10

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  • The first supramolecular photosensitization of enantiodifferentiating bimolecular reaction: anti-Markovnikov photoaddition of methanol to 1,1-diphenylpropene sensitized by modified beta-cyclodextrin International journal

    G Fukuhara, T Mori, T Wada, Y Inoue

    CHEMICAL COMMUNICATIONS   ( 16 )   1712 - 1714   2006

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  • "Molecular magic". Formation of a self-inclusion complex from a dumbbell-shaped permethylated beta-cyclodextrin derivative

    T Yamada, G Fukuhara, T Kaneda

    CHEMISTRY LETTERS   32 ( 6 )   534 - 535   2003.6

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  • Synthesis and characterization of the first pair of an unlocked and a locked self-inclusion complex from a permethylated alpha-cyclodextrin derivative

    G Fukuhara, T Fujimoto, T Kaneda

    CHEMISTRY LETTERS   32 ( 6 )   536 - 537   2003.6

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  • 完全メチル化シクロデキストリンの分子内反転機構

    ケミストリーレターズ   ( 32 )   534   2003

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  • 完全メチル化シクロデキストリンを含む分子内包接錯体の合成

    ケミストリーレターズ   ( 32 )   536   2003

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Research Projects

  • 動的らせん高分子によるキラリティー増幅センシング

    Grant number：24K21791  2024.6 - 2026.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    福原 学

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    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

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  • 高分子センサーによるシグナル増幅センシング：増幅計測の限界突破に向けて

    Grant number：24K01536  2024.4 - 2028.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    福原 学

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    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

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  • Sumanene Science 3.0: Unique Electronic amd Structural Functions Based on the Curved Aromatic System

    Grant number：24H00460  2024.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Grant amount：\47710000 （ Direct Cost: \36700000 、 Indirect Cost：\11010000 ）

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  • 静水圧による共役分子の動的な高密度化とそのキラー計測

    Grant number：23H04020  2023.4 - 2025.3

    日本学術振興会  科学研究費助成事業  学術変革領域研究(A)

    福原 学

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    Grant amount：\7800000 （ Direct Cost: \6000000 、 Indirect Cost：\1800000 ）

    今年度は、高密度共役科学に必須と考えられる「集積のエントロピー項」や「ナノ空隙」を外部刺激によって能動的に制御する、すなわち共役分子の“dynamic control”を目標とし、「静水圧による共役分子の動的な高密度化とそのキラー計測」を目論んだ。実際に幅広い分子群の静水圧計測を行い、多くの結果が出たが、ここでは、ポルフィリンクリップについて詳述する。静水圧下での蛍光スペクトルにおいて、クリップ誘導体１では静水圧印加によって、436 nm付近に観測されるポルフィリンのS2発光と605 nm付近のS1発光の単調な減少が観測された。一方クリップ誘導体２では、クリップ誘導体１と同じくS1発光は減少していくが、S2発光が増加するといったレシオメトリックな挙動が観測された。この現象はポルフィリンを修飾している足場の柔軟性に起因しており、より柔軟なリンカーの誘導体では加圧に伴い分子内のポルフィリン間の距離が近くなり、分子内で会合体が形成されたためであると考えられる。これら二つの誘導体の静水圧蛍光スペクトルから、圧力に対して蛍光強度比をプロットしたところ、非常に良い相関関係が見られ、蛍光強度比によって静水圧の定量化を達成した。

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  • Signal-amplification Chemosensors through Allosterism

    Grant number：19H02746  2019.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\16900000 （ Direct Cost: \13000000 、 Indirect Cost：\3900000 ）

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  • Functional Chiral Materials based on Propeller Chirality Dynamics

    Grant number：18K19077  2018.6 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Mori Tadashi

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    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

    This study revealed that the hexaarylbenzene derivatives are able to function as unique chiral materials due to their propeller chirality and the dynamic propeller-blade interactions. Success of our implication and the detailed experimental observations have been published in more than 30 research papers as well as invited international lectures and in other media. A review article related on this topic has been selected as a highly cited manuscript and the first book on this subject was appeared recently.

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  • Supramolecular Allosteric Signal-amplification Sensing Based on Flexible Polymers

    Grant number：16H06041  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (A)

    Fukuhara Gaku

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    Grant amount：\25350000 （ Direct Cost: \19500000 、 Indirect Cost：\5850000 ）

    The present studies obtained provided with new concepts for "Supramolecular Allosteric Signal-amplification Sensing" proposed by us. A new series of reporter-modified curdlans showed very high cooperativity and positive homotropic allosterism with high limit of detection. All of the results thus obtained can be expanded to other oligosaccharides and analytes that are difficult to sense in biomolecular media.

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  • Asymmetric Photoreactions through Charge-Transfer Band Excitations

    Grant number：15H03779  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Mori Tadashi

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    Grant amount：\13260000 （ Direct Cost: \10200000 、 Indirect Cost：\3060000 ）

    Photoexcitation of donor-acceptor or charge transfer complex leads to the excited charge transfer complex as reactive intermediate, which has been recently revealed different from the conventional exciplex in its structure as well as its reactivity. In this study to utilize the excited charge transfer complex for the asymmetric photoreaction, we explored additional supramolecular or weak interaction as precisely stereo-controlling factor. We also examined the photoreactions in the excited triplet state, where a longer excited-state lifetime and thus better control can be attained. Extended work on the relevant photochemical behavior of chiral charge transfer complex is now underway in the following project.

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  • Chiral Materials based on Fused Helicene Derivatives

    Grant number：15K13642  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Mori Tadashi

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    Circularly polarized luminescence (CPL) of organic molecules has been less explored until recently. We focused in this study on the variety of chiral organic molecules including helical chirality in helicenes, propeller chirality in hexaarylbenzenes, as well as Mobius chirality in expanded porphyrins. Through our systematic investigation, we successfully obtained the structure-property relationship for the chiroptical responses, which can be utilized for design principle for advanced organic CPL materials. Results have been appeared in 36 international original papers. In addition, a relevant review article is under preparation and a book related on CD and CPL on small organic molecules is edited, both of which should be distributed shortly.

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  • Hybridization Dynamics of Glucans with Polythiophene and Application to Sensing

    Grant number：26620061  2014.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Fukuhara Gaku

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    The author has elucidated the mechanism of dynamic glucan-polythiophene hybridization by using curdlan and schizophyllan as representative unbranched and branched linear polysaccharides and polycationic PyPT as a chromophoric hybridization partner. The in situ hybridization to hetero-triplex [(Cur)2-PyPT] upon addition of an aqueous solution of PyPT to a DMSO solution of Cur at ambient temperatures turned out to be far from completion. It should be emphasized that polycationic PyPT can unzip Cur homo-triplex and hybridize with the resulting homo-duplex in neutral aqueous solutions, despite that Cur homo-triplex does not show any sign of disassembling even at high temperatures in the absence of PyPT or in the presence of neutral PT. Interestingly, the hetero-triplex disassembles to hetero-duplex at very high pHs (>11) through further deprotonation from Cur in the hetero-triplex.

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  • Chiral Amplification through Organocatalytic Photochirogenesis with Higher-Order Supramolecular Complex

    Grant number：26620030  2014.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    INOUE Yoshihisa

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    Photochirogenesis has rapidly developed in recent years as an alternative methodology to complement the conventional asymmetric syntheses using chiral catalysts and enzymes. In the present study, we have achieved the simultaneous enhancement of reactivity and stereoselectivity in an enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylic acid through the formation of a novel higher-order (2:2) complexation with L-prolinol, which was shown to be expandable to a wider range of photosubstrates with carboxylic acid moiety/ies. This enabled us to accomplish the organocatalytic supramolecular photochirogenesis for the first time, which is inherently difficult and hence has never been achieved in asymmetric synthesis mediated by a chiral template.

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  • Asymmetric Photoreactions through Charge-Transfer Band Excitations

    Grant number：23350018  2011.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Mori Tadashi, FUKUHARA Gaku

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    Grant amount：\17550000 （ Direct Cost: \13500000 、 Indirect Cost：\4050000 ）

    In this study on the asymmetric photoreactions of chiral charge-transfer complex, we explored the generality of wavelength effect and mechanistic investigations. We employed three different photoreactions (two intermolecular and one intramolecular systems) to reveal the different excited complexes are always formed in all systems studied. We have published some of the results in three J. Am. Chem. Soc. papers (Impact Factor = 11.4), delivered the invited lectures in international conferences such as GRC Photochemistry, as well as contributed as invited review article in Chem. Soc. Rev. (Impact Factor = 24.9).

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  • Functional Polymer-Based Allosteric Chiral Snesing

    Grant number：23750129  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    FUKUHARA Gaku

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    The applicant has expanded his work to polymer-based supramolecular sensing of bio-related materials. To develop a chirality sensing system based on polythiophene, a permethylated cyclodextrin was attached to monothiophene unit with a hexamethylene spacer,which was then polymerized to give novel functional polythiophenes with chirality recognition sites. The cyclodextrin-appended polythiophene showed high enantioselectivity of 13.7 for phenylalanine dipeptide.
    To further achieve a more difficult task by constructing a saccharide sensor operative in aqueous media, the applicant employed polysaccharide curdlan (Cur) as a hydrogen-bonding saccharide receptor. Thus, the saccharide sensing by using native Cur/polythiophene complex hybridized in situ as a signal-amplifying reporter enabled us to selectively sense acarbose among 24 mono-, di-, tri, tetra-, and pentasaccharides.

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  • Hypermolecular Photochirogenesis

    Grant number：21245011  2009.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    INOUE Yoshihisa

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    Grant amount：\47190000 （ Direct Cost: \36300000 、 Indirect Cost：\10890000 ）

    In this study, we first elucidated the chiral properties, guest affinities, and photochirogenic performances of inorganic, organic, and biological supramolecular systems, and then developed various novel chiral supramolecular combination systems and established the multidimensional control strategies, which were jointly applied to several photochirogenic reactions to ultimately achieve unprecedentedly high optical yields of up to 99%, which has been a sort of dream for researchers working in this area of science. We published 97 original papers and reviews as well as the first book on this new interdisciplinary area at the intersection of photochemistry, supramolecular chemistry, and asymmetric synthesis to enhance its visibility in science community.

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  • The creation of functional materials based on novel chiral polymers

    Grant number：20850023  2008 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (Start-up)

    FUKUHARA Gaku

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    Grant amount：\3276000 （ Direct Cost: \2520000 、 Indirect Cost：\756000 ）

    In the ground state, a newly synthesized polythiophene possessing an optically active binaphthyl tethered by an oxyethylene linker is capable of recognizing various amino acid derivatives as chiral cationic guests. In sharp contrast to the ground-state polymer chemistry, photoirradiation of anthracenecarboxylate-appended cellulose gave the cyclodimers with high stereoselectivities, examined the detailed diastereodifferentiating mechanism.

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  • 修飾シクロデキストリン及びキュカービチュリル類縁体を用いた超分子不斉光化学反応

    Grant number：06J08918  2006 - 2007

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    福原 学

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    Grant amount：\1900000 （ Direct Cost: \1900000 ）

    申請者はこれまでキラルなホスト分子として、光増感剤修飾シクロデキストリンやキュカービチュリル類縁体ならびにキラル分子クリップを合成し、これらの基底状態でのキロプティカル特性を調べるとともに励起状態での光不斉反応を報告してきた。今年度は学振PDとして、従来の分子認識に関する知識と経験を活かせ、なおかつ新しい分野にも挑戦できる環境としてマサチューセッツ工科大学(MIT)のSwager研に留学し、高感度センサー開発のために水素結合供与体であるチオウレア骨格を有するポリチオフェン誘導体を合成した。このポリマーのTHF溶液にカーボンナノチューブ(CNT)を添加した後に、超音波攪拌を数時間行い均一な溶液とした。得られた混合溶液をガラス基盤上に塗布し、スピンコーティング法により得られた薄膜材料による種々の爆発物(2,4-ジニトロトルエン、ニトロベンゼン、2,4-ジニトロベンゼン)ならびに毒性の高い揮発性薬品(アルデヒド類、ケトン類、MeOH、THF)の電流応答性を検討した結果、水素結合受容体の化学蒸気に対して高い選択性を示した。また、チオウレア部を持たない制御ポリマーを合成し、ドロップキャスティング法により得た混合フィルムで、同様の揮発性薬品の電流応答を比較検討した結果、確かにポリマー主鎖上のチオウレア部がCNT表面での蒸気認識においても大きな役割を果たしていることが明らかとなった。これらの結果はMacromolecules(ACS)に投稿準備中である。

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  • キラルキュカービチュリル類縁体を用いた超分子光不斉反応

    2004 - 2007

    その他の研究制度 

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    Grant type：Competitive

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  • Supramolecular photochirogenesys using chiral cucurbit[n]uril analogues

    2004 - 2007

    The Other Research Programs 

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    Grant type：Competitive

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  • 修飾シクロデキストリン内での超分子光不斉反応

    2004 - 2007

    その他の研究制度 

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    Grant type：Competitive

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  • Supramolecular photochemistry using modified-cyclodextrins

    2004 - 2007

    The Other Research Programs 

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    Grant type：Competitive

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